<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WPX4</accession>
    <name>A0A173WPX4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">glmS_1</name>
        <name evidence="8 12" type="synonym">glmS</name>
        <name evidence="11" type="ORF">ERS852478_00029</name>
        <name evidence="12" type="ORF">GT712_07760</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381098.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41531">
        <property type="protein sequence ID" value="CUN41531"/>
        <property type="gene ID" value="ERS852478_00029"/>
    </dbReference>
    <dbReference type="GeneID" id="66492903"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="289"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="462"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN41531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS88967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="613" mass="67984" checksum="89D920843F9ED8D0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WRH3</accession>
    <name>A0A173WRH3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NAD(P)H-dependent oxidoreductase subunit E</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase subunit E</fullName>
            <ecNumber evidence="7">1.6.5.11</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="11">NADP-reducing hydrogenase subunit HndA</fullName>
            <ecNumber evidence="11">1.12.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nuoE_1</name>
        <name evidence="11" type="synonym">hndA</name>
        <name evidence="11" type="ORF">BWLFYP14_02549</name>
        <name evidence="7" type="ORF">ERS852478_00048</name>
        <name evidence="8" type="ORF">ERS852523_00719</name>
        <name evidence="10" type="ORF">GT712_07665</name>
        <name evidence="9" type="ORF">GT728_03200</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="7"/>
    <dbReference type="EC" id="1.12.1.3" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP15636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000005">
        <property type="protein sequence ID" value="MZL32227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703034.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1412"/>
    <dbReference type="EnsemblBacteria" id="CUN42113">
        <property type="protein sequence ID" value="CUN42113"/>
        <property type="gene ID" value="ERS852478_00048"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15636">
        <property type="protein sequence ID" value="CUP15636"/>
        <property type="gene ID" value="ERS852523_00719"/>
    </dbReference>
    <dbReference type="GeneID" id="66492884"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050583">
        <property type="term" value="F:hydrogen dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN42113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP15636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL32227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS88948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX66177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="159" mass="17831" checksum="DD7BA9BB7E1F8C67" modified="2016-09-07" version="1">MLDQSYYRKADEIIEHYGRTAASLIPIMQDIQAEYRYLPGELLTYVAKEIGVKEAKAYSVATFYENFSFEPKGKYVIKVCDGTACHVRKSMPVKEALMKELGLSNKKHTTDDMLFTVETVSCLGACGLAPTLTVNDEVHPKMTPEKAVELLNKLRGECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WT67</accession>
    <name>A0A173WT67_9FIRM</name>
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        <submittedName>
            <fullName evidence="3">FeoB-associated Cys-rich membrane protein</fullName>
        </submittedName>
        <submittedName>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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        <name evidence="2" type="ORF">ERS852478_00064</name>
        <name evidence="4" type="ORF">GT712_07585</name>
        <name evidence="3" type="ORF">GT728_03120</name>
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    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
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    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
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    </reference>
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        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66193.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN42673">
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        <property type="gene ID" value="ERS852478_00064"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN42673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="43" mass="4438" checksum="FE3F29CB673CF637" modified="2016-09-07" version="1">MGTLIVGAILILIVGLIIRGIVRDKKSGKSSCGGDCSHCRGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WUK6</accession>
    <name>A0A173WUK6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase iron-sulfur subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BWLFYP14_02538</name>
        <name evidence="6" type="ORF">ERS852478_00037</name>
        <name evidence="8" type="ORF">GT712_07720</name>
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    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
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            <taxon>Firmicutes</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">BIOML-A1</strain>
            <strain evidence="8 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000031">
        <property type="protein sequence ID" value="MZL34058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="VUX66166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703021.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41768">
        <property type="protein sequence ID" value="CUN41768"/>
        <property type="gene ID" value="ERS852478_00037"/>
    </dbReference>
    <dbReference type="GeneID" id="66492895"/>
    <dbReference type="eggNOG" id="COG1150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN41768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL34058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS88959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="129" mass="14643" checksum="59916CB06D5861A0" modified="2016-09-07" version="1">MRNQHSAAEKIKEISGTNPLKCMKCGKCSATCPSFNEMDIKPHQFVSYVVNEDIEALVNSKSLWKCLSCFACVERCPRDVKPGKIIDAARQLVVREKGGDYLKADEIPQLLDPELPQQLLVSAFRRYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X0E4</accession>
    <name>A0A173X0E4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="10">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">miaB_1</name>
        <name evidence="10" type="synonym">miaB</name>
        <name evidence="14" type="ORF">ERS852478_00158</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="9 10"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45221">
        <property type="protein sequence ID" value="CUN45221"/>
        <property type="gene ID" value="ERS852478_00158"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="12">
        <location>
            <begin position="30"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="171"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="11">
        <location>
            <begin position="404"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN45221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="466" mass="53391" checksum="9F55BE903E3B3AEC" modified="2016-09-07" version="1">MNNNTQESKIQLEYINKCTELVKEKYKKAPAFFIQNAGCQMNSLQTDTVAGIVKRMGYTEVSREEDADVVIYNTCTVRENANLKIYGHLGHLKSIKKKNPELKIILFGCMMQEPEVIEKIHKEYSFVDLVFGTHNFHKFPELFYRSLNTEGQIIDVWKESDEIVEGMPSDRKYSFKTGVNIMFGCNNFCSYCIVPYVRGREKSREPEAIIEEIKGLVADGVTEVMLLGQNVNSYGKTLEHPVTFAQLLKQVEAIEGLKRIRFMTSHPKDLSDELIRTMAESKKVCHHLHLPMQSGSSRILKIMNRRYDKEKYLELVAKIRNAVPDISLTTDIIVGFPGETEEDFQDTLDVVEKCDFDSAFTFIYSKRSGTPAAKMENQVPEDVVKDRFDRLLALVQEKGRKASSRFEGTVQEILVEEESREKGIFTGRTEYNLLVHFPGCQDLIGKYVKVKLDTCKGFYYFGSLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X3V4</accession>
    <name>A0A173X3V4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.99.7</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Selenium-dependent xanthine dehydrogenase</fullName>
            <ecNumber evidence="5">1.17.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mop_1</name>
        <name evidence="5" type="synonym">xdh</name>
        <name evidence="4" type="ORF">ERS852478_00198</name>
        <name evidence="5" type="ORF">GT712_00470</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.99.7" evidence="4"/>
    <dbReference type="EC" id="1.17.1.4" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380732.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46294">
        <property type="protein sequence ID" value="CUN46294"/>
        <property type="gene ID" value="ERS852478_00198"/>
    </dbReference>
    <dbReference type="GeneID" id="66495826"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033727">
        <property type="term" value="F:aldehyde dehydrogenase (FAD-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017697">
        <property type="entry name" value="Xdh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03311">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN46294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS87601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="860" mass="93727" checksum="9B981DD52DED2652" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XEC8</accession>
    <name>A0A173XEC8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable sensor-like histidine kinase YehU</fullName>
            <ecNumber evidence="6">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yehU_1</name>
        <name evidence="6" type="ORF">ERS852478_00295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199554.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50172">
        <property type="protein sequence ID" value="CUN50172"/>
        <property type="gene ID" value="ERS852478_00295"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="337"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN50172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="607" mass="68715" checksum="7BFDE5E096F8ADAF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XEP3</accession>
    <name>A0A173XEP3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">senX3</name>
        <name evidence="10" type="synonym">senX3_2</name>
        <name evidence="9" type="ORF">ERS852478_00259</name>
        <name evidence="10" type="ORF">ERS852523_04042</name>
        <name evidence="11" type="ORF">GT712_17765</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
            <strain evidence="10 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000077">
        <property type="protein sequence ID" value="CUQ12165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000054">
        <property type="protein sequence ID" value="MZS90848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706583.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000119.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49105">
        <property type="protein sequence ID" value="CUN49105"/>
        <property type="gene ID" value="ERS852478_00259"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ12165">
        <property type="protein sequence ID" value="CUQ12165"/>
        <property type="gene ID" value="ERS852523_04042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
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    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="201"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="167"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN49105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUQ12165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS90848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="421" mass="48460" checksum="3156DAD92D46C84A" modified="2016-09-07" version="1">MESGGKAVTKRYRKKITVVLSLVLPVILLFAILNCFTTYVFYEDYKYKMNLMTEIAAKEEFSGLDAVSELLKDKDIETNEQGRRLLEQYGYWGNKGNAFYSQFRHQVMVTGAVSTVICVLLLTFLLYWKKKEDACHQKILDQLEEILIRFRENKFDDLLKTENHAELEKLNDQLEAIGHHIQLIKEEARAEKENTKEMVSDISHQLKTPVAALDTCFSVLMQNDLSATEQEEFRIRCRSALDGLETLLQSLLEISKMETGLIQINKKKLPLMDTVISAVNRTYPKADEKEIEFVFDYEKELETCTIMQDKRWLGEAVINVLDNAVKYSPCGSKIFIRLQKRNDLVRMEIEDQGIGIPQNEYHKIFQRFYRGSSKEVMEKSGTGIGLFLSREIIEKHAGTITVTSGKKKKGSTFVIQLPYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XMI5</accession>
    <name>A0A173XMI5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase/lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381330.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52057">
        <property type="protein sequence ID" value="CUN52057"/>
        <property type="gene ID" value="ERS852478_00354"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="98"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN52057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="328" mass="38535" checksum="816CE109DA7F3F4A" modified="2016-09-07" version="1">MKKKFFRLSAAVLLFFSGIMEIGWRFFNMVVCCKRGGRKKERKKWFELSHIRDNHPRNGYAKEYDESRAWCETQKMQDCYIQSVDGLKLHGFYLPAEHAKRFVILSHGYRGSRFGSLSFMAKYLHEHQCNLLFMEQRCCGESEGKYITFGAKEKWDVQRWAIYVSERNKEKLPIYLYGQSMGAAAVLMASGYRLPSEVKGLIADCGFQSMERQMRDMADNWFHLHYIPLLLKEMDCLCHFVAGFRMKDADTTEAMKRNTRPVLFFHGEKDTYVYPNNSFQNYMLCKAPKELVIVQGARHLCSAYADPELYQRTVMEFFEKYDGSNSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XNS7</accession>
    <name>A0A173XNS7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacterial protein of uncharacterized function (DUF961)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199602.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53542">
        <property type="protein sequence ID" value="CUN53542"/>
        <property type="gene ID" value="ERS852478_00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010365">
        <property type="entry name" value="DUF961"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038620">
        <property type="entry name" value="YdcP-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06125">
        <property type="entry name" value="DUF961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="127" mass="14132" checksum="3EAD15433FEE59C4" modified="2016-09-07" version="1">MRLSNGFVIDKEKTFGELKFTAVRDVFLQNEDGTPSTQIKKRIYDLKCSLHDGIIPVSVPPEVPLREFPYNAVVEIVNPVADTVSRKTYTGADVDWYVKAEDIVLKNKGNQNAGSPQSPTPQGQPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XQB1</accession>
    <name>A0A173XQB1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199596.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53087">
        <property type="protein sequence ID" value="CUN53087"/>
        <property type="gene ID" value="ERS852478_00389"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="52"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="213" mass="24386" checksum="3179B7B359866581" modified="2016-09-07" version="1">MKNEEYKKLSIAEFTKAAGRYESNHAGIYEMCKKDYPDILEELEKEPFRDLLDAGCGPAPMITLLAEKYPDRHYTGLDLTPAMIEQAKKKNISNATFVVGDCENFPFENDSFDAIICSMSFHHYPDPQAFFDSVKRCLRPNGRLILRDVTSDNKVLVWLMNTLEMPLANICGHGDVRVPTRDVVMKCCRKVGLKVEKFEIRKGMRMHCVVRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XRF1</accession>
    <name>A0A173XRF1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional repressor AcrR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_02019</name>
        <name evidence="3" type="ORF">ERS852478_00391</name>
        <name evidence="4" type="ORF">ERS852523_01581</name>
        <name evidence="5" type="ORF">GT728_06375</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
            <strain evidence="4 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000013">
        <property type="protein sequence ID" value="CUP42468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000011">
        <property type="protein sequence ID" value="MZL32837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579141.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000034_gene3872"/>
    <dbReference type="EnsemblBacteria" id="CUN53155">
        <property type="protein sequence ID" value="CUN53155"/>
        <property type="gene ID" value="ERS852478_00391"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP42468">
        <property type="protein sequence ID" value="CUP42468"/>
        <property type="gene ID" value="ERS852523_01581"/>
    </dbReference>
    <dbReference type="GeneID" id="66496029"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN53155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP42468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL32837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="209" mass="24409" checksum="D447CDD1419DB3C8" modified="2016-09-07" version="1">MSTKAEDTQKNILDTARKHFLKDGLTGASLRNIVKDAGLTTGAFYKYYPTKEALFDALTDPYMEHIYQIYDQIVEEFEKLSASDQTRNMSDTSSDGMEQMVDYIYDHYDNFRLLLKCGDSGKFELFIHNMVEREMKSSLKYMEKMKEAGVKIPVVEESLMHMIYTGFFSSVFQIIEHDIDRETAKKNVHQLKEFNTGGWERLWNIEFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y301</accession>
    <name>A0A173Y301_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-carbamoyl-D-amino acid hydrolase</fullName>
            <ecNumber evidence="2">3.5.1.77</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="3">N-carbamoylputrescine amidase</fullName>
            <ecNumber evidence="3">3.5.1.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aguB</name>
        <name evidence="5" type="ORF">BWLFYP14_02115</name>
        <name evidence="2" type="ORF">ERS852478_00515</name>
        <name evidence="4" type="ORF">GT712_12430</name>
        <name evidence="3" type="ORF">GT728_11395</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.77" evidence="2"/>
    <dbReference type="EC" id="3.5.1.53" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000026">
        <property type="protein sequence ID" value="MZL33784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000024">
        <property type="protein sequence ID" value="MZS89852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000038">
        <property type="protein sequence ID" value="VUX65636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708143.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57960">
        <property type="protein sequence ID" value="CUN57960"/>
        <property type="gene ID" value="ERS852478_00515"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047417">
        <property type="term" value="F:N-carbamoyl-D-amino acid hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050126">
        <property type="term" value="F:N-carbamoylputrescine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017755">
        <property type="entry name" value="N-carbamoylputrescine_amidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03381">
        <property type="entry name" value="agmatine_aguB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN57960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="292" mass="32913" checksum="2122C34A1E21CD00" modified="2016-09-07" version="1">MRNVTVAAVQMKCSKSVEKNIAHAEELVRQAAAKGAEIVLLPELFERPYFCQERRYEYYEYAQTAEENPAVRHFSRVAAELGIVIPVSFYEKEVNNTYNSVAVLDADGKNLGIYRKTHIPDDHYYQEKFYFTPGDTGFKVFDTRFGTIGVGICWDQWFPETARCMALQGAELLFYPTAIGSEPILECDSMEHWRRCMQGHAASNLIPVIAANRIGEETVEPCPENGMQKSALNFYGSSFITDNTGALCAELPGGEEGVLVSTFDLDALKADRLNWGLFRDRRPEMYAKIVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y686</accession>
    <name>A0A173Y686_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Guanine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">guaD</name>
        <name evidence="3" type="ORF">ERS852478_00553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.4.3" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59070">
        <property type="protein sequence ID" value="CUN59070"/>
        <property type="gene ID" value="ERS852478_00553"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="60"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN59070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="425" mass="47405" checksum="E908E1B8421BFC4B" modified="2016-09-07" version="1">MNERTFVLKGTICYSNSLTELSITENGYLVCEDGRCAGVFDELPEKFAGISCTDFGDELIIPGLTDLHLHAPQYTFRASGMDLELLDWLNTYTFPQEARYEDTEFAKEAYSIFTENMKKSPNTRACIFGTLHVPATEILMEQLDKTGIKAMVGKVNMDRNGSPQLQEESAQASADATVQWIKDTLDKFENVKPILTPRFTPSCSDELMEKLSEIQKRYHLPMQSHLSENFGEIAWVKELCPNTHFYGEAYSQFDLFGGDCPTIMAHCVHSSDEEIALMKKQGVYIAHCPQSNTNLASGISPARRYLDEGLHIGLGSDIAGGTSVSILRAMADAIQVSKLYWRLVDSSMKPLTVEEAFYMGTEGGGSFFGKVGSFKEGYEFDAVVLNDSTIPTPLKLSPKDRLERLIYLSDDRNITAKYVAGRKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YFZ0</accession>
    <name>A0A173YFZ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator immR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">immR_1</name>
        <name evidence="2" type="ORF">ERS852478_00652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN62430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199734.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN62430">
        <property type="protein sequence ID" value="CUN62430"/>
        <property type="gene ID" value="ERS852478_00652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN62430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="345" mass="40328" checksum="AE847D61F9FA9AAD" modified="2016-09-07" version="1">MNIGSVIKKYRKVSGFTQEEMANRLGVTTPAVNKWENGNSNPDIELLAPIARLLHISLDTLLSFHENLTDVEITELIQEMDKMFSVEGYEKTYQWAVNIIKDYPNCNMLIWQVAVMLDSRRIIGQCEHPDKYDEQINFWYEIALNDKDEKIQHHAADSLFGFYLRKGNYEMAEKYLNYFSDYDPMKKLKLGQLYMEQEKTEEAYEKLENIILSEYTTLNLAFGMMITKALDKKDHKSARFLAEKMCALAGVFEMGKYSECATMFNVVVAEQNVEGTFNVVKQLLENVDTICDFQKSRLYKHIKFQDAENPYAEEMKKELIAGFQNEEDFAYMKGYKPWKKLLAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YKC0</accession>
    <name>A0A173YKC0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-xylosidase</fullName>
            <ecNumber evidence="3">3.2.1.177</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yicI_1</name>
        <name evidence="3" type="ORF">ERS852478_00662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.177" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN63757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199746.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63757">
        <property type="protein sequence ID" value="CUN63757"/>
        <property type="gene ID" value="ERS852478_00662"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061634">
        <property type="term" value="F:alpha-D-xyloside xylohydrolase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN63757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="677" mass="78130" checksum="0B683A7ACF01DBCD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YQL2</accession>
    <name>A0A173YQL2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division protein FtsQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65088">
        <property type="protein sequence ID" value="CUN65088"/>
        <property type="gene ID" value="ERS852478_00702"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005548">
        <property type="entry name" value="Cell_div_FtsQ/DivIB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03799">
        <property type="entry name" value="FtsQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="FtsQ" evidence="3">
        <location>
            <begin position="102"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN65088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="372" mass="40945" checksum="90E8E4F17CE4F37D" modified="2016-09-07" version="1">MLAGMIGAGVMVAVIVFFSYYKVDTVEVRGTSHYTDEEVKNMVLRGPMASNSVLAPLLYSTTNTEDIAYVDAFKVTQLNRNTICISVKEKKTVGCIRYLDSYIYFDRNGIFVEGSQNRDETVPYFDGIQVNSIVMDEKLDIKGDTVLNTAVALSTIFQKNDMIPDHIQFDSSYSISLIYGDITVQLGKDADLEEKMNRVIAILPKIQGKKGILHMESVATESNTFEEELEQEEVTAENWNGGYDEDGNYTGDGEYDEDGNYVGAKPKTALEEAIENWNGGYDEEGDYTGAGEYDESGNYVGPKPTQESLDAASDESGDGSGDESSADDQSSETSEDGESDSSYDDRNSDDSDGYGDYTEDNSDYQGDDSEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YS25</accession>
    <name>A0A173YS25_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Primosomal protein N'</fullName>
            <ecNumber evidence="10">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">priA</name>
        <name evidence="13" type="ORF">BWLFYP14_01784</name>
        <name evidence="12" type="ORF">ERS852478_00737</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706494.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66330">
        <property type="protein sequence ID" value="CUN66330"/>
        <property type="gene ID" value="ERS852478_00737"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040498">
        <property type="entry name" value="PriA_CRR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18319">
        <property type="entry name" value="PriA_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="221"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN66330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX64994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="739" mass="84079" checksum="1D509875DABEB2CE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YUA7</accession>
    <name>A0A173YUA7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ACT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706457.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67109">
        <property type="protein sequence ID" value="CUN67109"/>
        <property type="gene ID" value="ERS852478_00759"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045739">
        <property type="entry name" value="ACT_dom_pair"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19571">
        <property type="entry name" value="ACT_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT_8" evidence="1">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN67109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="142" mass="15816" checksum="A871C8E7DF732356" modified="2016-09-07" version="1">MIKQNVVFVENKAGSLKRVTGTLADNGINIYGFACFDAPEFAIFRMICNDPDKAEIVLNRSGYMNRITQAIVVDMKDQVGGLDELLKVASDSNVSLDYIYTSFHRKDLRPVVILQTEDGAVTECILKNNGFNVFTSAEELEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YWZ1</accession>
    <name>A0A173YWZ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase, nitrate /nitrite-specific</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_01736</name>
        <name evidence="3" type="ORF">ERS852478_00785</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199796.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68050">
        <property type="protein sequence ID" value="CUN68050"/>
        <property type="gene ID" value="ERS852478_00785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN68050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="461" mass="52991" checksum="EFD65ECC69CF8633" modified="2016-09-07" version="1">MVYQLYRLQKDRWKMIDFVECGMAMQDFLMILFEICLVLELILLLVRITCFSGKKKIVTAVAVFAVSFMFMGVLMNDHRYCLGESFYQPMLQGYPFSVLMTVVIGLLLYLCWAIRSERRRYHHSLSYWSVNEAVNDVPCGVCFSDPLGRIVLCNTKMQELSRIMTGSYLQDYEALRKAMSGEPESEGLCRLSKDSNVFYFPDGSVWMFQEYGLQEPDCAGYLQTVAVNVSEIYYNGEKIRANNEKLEILNHKLEEMYEKIGDKIREQETLVMKMQVHDNFGRSLLSIRRILERKEDPDKMDKQLSVLKHLVYILTGSAVESMEEVYEDTIRHAEELGISVQISGNFPMHPSYRLLTDRAIRECVTNCARHAHGSTVWVKIDKNADEYTVQITNDGEVPDKNAEEGGGLSALRKAAESGKCRMQVSFSPEFCLILKMPLTERMGFDGTDTDSRRSEDHAEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YX00</accession>
    <name>A0A173YX00_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nreC</name>
        <name evidence="8" type="ORF">BWLFYP14_01737</name>
        <name evidence="7" type="ORF">ERS852478_00784</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199795.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68009">
        <property type="protein sequence ID" value="CUN68009"/>
        <property type="gene ID" value="ERS852478_00784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN68009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX64899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="208" mass="24051" checksum="1D8D1BE3EEA91854" modified="2016-09-07" version="1">MVRILIVEDQKIMQKYFEYIIMQEPEFRHIQTVSDAREAVKICDYSAIDLVIMDVQTFHNHDGLSAGKEIREKYPYTKVLIVTSLIDPKVLERAKSGCADSLWYKDHGEEEIRSVIHRTLNGEHVFPDMTPKVELNWITSGDISPRQLEMLRLYIRGMSYSEIAREMKCSTSGVRWNFQEMIARAGYSCKEDLIAAALESKLIVTTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YXW4</accession>
    <name>A0A173YXW4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Predicted ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01728</name>
        <name evidence="2" type="ORF">ERS852478_00793</name>
        <name evidence="4" type="ORF">GT712_02805</name>
        <name evidence="3" type="ORF">GT728_12560</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000030">
        <property type="protein sequence ID" value="MZL34010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993632.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68350">
        <property type="protein sequence ID" value="CUN68350"/>
        <property type="gene ID" value="ERS852478_00793"/>
    </dbReference>
    <dbReference type="GeneID" id="66493566"/>
    <dbReference type="eggNOG" id="COG1106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="48"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN68350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="450" mass="52717" checksum="B2B7DFB5F1AE83EE" modified="2016-09-07" version="1">MLLNFKMENFRSFKDETFFTMLSSKQKTHNDYVIDKSVNGNKLRVLPMTVIYGANACGKSNIVLAMDILKKMVMKGTLNCKELESYKSMLSFIRDTSWYDPVSLEITFSTQNNIYRYGIKFTDIDVYKIEEEVLYVNDDLFFSRDDENQIYVDVKKLVKKGYINKDDADFSERLIHKLNQTLDKQKLVVAGAISNLFDKKYFEDFNLWFEKFNVIMNANDMNFRQKDLKTIFNKKPDKDIRRNIFESASVKEVMNIAEFGNQKIGFMAETDNDELSMCSMYQVPLRKDEQPQKKYAISMIVDSELMESRGTIHLIRLLQPFIDVLDNGGVIVLDEMDASLHFEIVVSLIRIFNNKDINKNNAQLIFNTHNPIYLDGELLRHDQIVMVEKRRNDMVSEIYSLADYKLRPEERILKNYLNGKYGALPHMDLEIAFKHILEREANNLESSKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YZA1</accession>
    <name>A0A173YZA1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HisKA_7TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199797.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68088">
        <property type="protein sequence ID" value="CUN68088"/>
        <property type="gene ID" value="ERS852478_00786"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031621">
        <property type="entry name" value="HisKA_7TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16927">
        <property type="entry name" value="HisKA_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_7TM" evidence="3">
        <location>
            <begin position="53"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="333"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN68088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="555" mass="64655" checksum="BBF08392F350AF83" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z7I2</accession>
    <name>A0A173Z7I2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="6">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">asnS_1</name>
        <name evidence="6 10" type="synonym">asnS</name>
        <name evidence="12" type="synonym">asnS_2</name>
        <name evidence="12" type="ORF">BWLFYP14_01254</name>
        <name evidence="8" type="ORF">ERS852478_00872</name>
        <name evidence="9" type="ORF">ERS852523_02473</name>
        <name evidence="11" type="ORF">GT712_08050</name>
        <name evidence="10" type="ORF">GT728_01095</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000026">
        <property type="protein sequence ID" value="CUP69153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS89021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706954.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000023_gene1794"/>
    <dbReference type="EnsemblBacteria" id="CUN71753">
        <property type="protein sequence ID" value="CUN71753"/>
        <property type="gene ID" value="ERS852478_00872"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP69153">
        <property type="protein sequence ID" value="CUP69153"/>
        <property type="gene ID" value="ERS852523_02473"/>
    </dbReference>
    <dbReference type="GeneID" id="66492998"/>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="144"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN71753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP69153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL31827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS89021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX64141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="463" mass="53237" checksum="C1CB0BFB53775F7C" modified="2016-09-07" version="1">MKLTTVKEIYKEREKYLDKEVTVGGWVRSVRDSKTFGFIVLHDGSFFETLQVVYHDTMENFAEISKLNVGAAIIVKGTLVATPQAKQPFEIQAAEVTVEGNSAPDYPLQKKRHSLEYLRTITHLRPRTNTFQAVFRVRSLCAYAIHRFFQEQGFVYVHTPLITGSDCEGAGEMFQVTTLDMNNVPTDDKGAVDYSQDFFGKETNLTVSGQLNCETFAQAFRNVYTFGPTFRAENSNTTRHAAEFWMIEPECAFADLNDNMDLAEAMLKYVIRYVLENAPEEMNFFNSFVDKGLLDRLNHVINSEFGHVTYTEAVELLEKNNDKFDYKVFWGCDLQTEHERYLTEEIFKKPVFVTDYPKEIKAFYMKMNEDNKTVAAMDCLVPGIGEIIGGSQREDDIEKLEKRMDELGLKKEDYDFYLDLRKYGSTRHSGFGLGFERCVMYLTGMGNIRDVIPFPRTVKNCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z985</accession>
    <name>A0A173Z985_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flp pilus assembly protein, protease CpaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72457">
        <property type="protein sequence ID" value="CUN72457"/>
        <property type="gene ID" value="ERS852478_00897"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="3">
        <location>
            <begin position="28"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN72457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="186" mass="20591" checksum="89832AF6C0C97BB9" modified="2016-09-07" version="1">MNSIETVAKNIRLEVMQYAFFHLFPVAVAGIAMIMDIRTAKVDNGWIIFSMSVGLFVCIWQKNITGIGFFIMGSVIPLFLMILFAFGMIGAGDIKLFCALGGIMGCESIIKCIFISFLTGAGISAALLIFNHNFCERILYFIEYVKCTVSTGKISSYRRKSIAAPENFHFTIPVFISVLLYAGGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZDJ1</accession>
    <name>A0A173ZDJ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted HD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059455.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73720">
        <property type="protein sequence ID" value="CUN73720"/>
        <property type="gene ID" value="ERS852478_00938"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="35"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN73720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="267" mass="30935" checksum="8A55F8B2C0FF9BE4" modified="2016-09-07" version="1">MDKLLDLTRDFDAAKAAFEAYLDEYDRADDKIHLKIVHTYGVVDAAEDIARRMGLGEEDVQLAKVIGLLHDIGRFEQIKRFDSFEPGTMEHAVYGAQLLFGPEKMIRRFVKDDRFDSLICTAIEKHSDFKLEGITDERTLLHAKLIRDADKLDNCRVKLEESMETLLGVDEKGVGEGVIAPKVWESCMAKESVLSSDRVSKVDYWISYIAQYYDINFPETYEIMREHDYVKRIMDRVPYALPETQEKMDILAAEMGEYMDERIRNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZDT6</accession>
    <name>A0A173ZDT6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase PapA5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199897.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74401">
        <property type="protein sequence ID" value="CUN74401"/>
        <property type="gene ID" value="ERS852478_00961"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4908">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046283">
        <property type="entry name" value="DUF6320"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19845">
        <property type="entry name" value="DUF6320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN74401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="606" mass="69893" checksum="B9064574E6357744" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZJT9</accession>
    <name>A0A173ZJT9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted P-loop ATPase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76073">
        <property type="protein sequence ID" value="CUN76073"/>
        <property type="gene ID" value="ERS852478_01010"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007936">
        <property type="entry name" value="VirE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05272">
        <property type="entry name" value="VirE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN76073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="431" mass="50859" checksum="A19A4CA7A01EC82C" modified="2016-09-07" version="1">MTQKGAVKNNRHNCKLILEHDPLLKDVFRHNILTEQTDIVKPVWWERISPAFTDMDLNYIMLYLEETYGLTMDKIVQKSIVHQADRNKYHPVRDYLNSLQWDGQERIRYVLHHFLGAPVDELTYESMKMFLLGAIARAFRPGIKFEYMLCLVGGQGVGKSTFFRFMAVKDDWFTDDIGKLDSEKVYCQLRGHWMIEMSEMVATARSKSIEETKSFLSRQKETYRDSYAVYALDRPRQCVFGGTSNIKRFLPFDRTGNRRFVPVQTNRAEMEVHILENEKESRQYIDQVWAEAMMLYRNGNFKLAFSKETETQLDKLRQEFMADDTEAGMIQAWLDEHEDRKVCSLMLFKEALDNPYVKPKKAETDRICEIMNTSIVGWKQGTMTRFKDYGTQRSWVCVNENCKRDAKDLKNENDWHPITEKEARQVELPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZTG6</accession>
    <name>A0A173ZTG6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein L11 methyltransferase</fullName>
            <shortName evidence="2">L11 Mtase</shortName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">prmA</name>
        <name evidence="3" type="ORF">ERS852478_01066</name>
        <name evidence="4" type="ORF">ERS852523_02681</name>
        <name evidence="5" type="ORF">GT728_14285</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Methylates ribosomal protein L11.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000030">
        <property type="protein sequence ID" value="CUP75119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000037">
        <property type="protein sequence ID" value="MZL34335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381215.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000035_gene3842"/>
    <dbReference type="EnsemblBacteria" id="CUN78949">
        <property type="protein sequence ID" value="CUN78949"/>
        <property type="gene ID" value="ERS852478_01066"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP75119">
        <property type="protein sequence ID" value="CUP75119"/>
        <property type="gene ID" value="ERS852523_02681"/>
    </dbReference>
    <dbReference type="GeneID" id="66496219"/>
    <dbReference type="eggNOG" id="COG2264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00735">
        <property type="entry name" value="Methyltr_PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004498">
        <property type="entry name" value="Ribosomal_PrmA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000401">
        <property type="entry name" value="RPL11_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00406">
        <property type="entry name" value="prmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN78949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP75119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL34335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="317" mass="35294" checksum="5BA87847BF4BFDB6" modified="2016-09-07" version="1">MKWNRFTVKTKTEAEDIVISTLAEVGIEGVEIQDKQPLTEEDKAQMFVDIMPEGPADDGIAYLNFYLEEDADKEAILKDVREALDDLKNFMDIGEATIEESQTEDKDWINNWKQYFHQFYVDDILIVPSWEEVKAEDKDKMILHIDPGTAFGTGMHETTQLVIRQLKKYVTPDTEMLDVGTGSGILGIVALKLGAKHVLGTDLDPCAVPAVAENKEANQIVDETFDMVIGNIIDDKAIQDQAGYEKYDIVTANILADVLIPLTPVIVNQMKKGAYYITSGILDVKEEVVVEAVKAAGLTVVEVTHQGEWVSVTARKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZTW3</accession>
    <name>A0A173ZTW3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dnaJ_1</name>
        <name evidence="6 12" type="synonym">dnaJ</name>
        <name evidence="14" type="ORF">BWLFYP14_00344</name>
        <name evidence="11" type="ORF">ERS852478_01064</name>
        <name evidence="13" type="ORF">GT712_13625</name>
        <name evidence="12" type="ORF">GT728_14295</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">BIOML-A1</strain>
            <strain evidence="13 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000037">
        <property type="protein sequence ID" value="MZL34337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000028">
        <property type="protein sequence ID" value="MZS90083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381214.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78866">
        <property type="protein sequence ID" value="CUN78866"/>
        <property type="gene ID" value="ERS852478_01064"/>
    </dbReference>
    <dbReference type="GeneID" id="66496217"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="141"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="154"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="171"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="197"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="211"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="141"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="363"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN78866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL34337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS90083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX67499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="395" mass="43210" checksum="CEB01EE3DC4FF8AA" modified="2016-09-07" version="1">MADKRDYYEVLGVDKSADDATLKKAYRKLAKKYHPDVNPGDKEAEAKFKEATEAYTILSDPEKRKQYDQFGHAAFENGGGGAGGGFGGFDFNGADMGDIFGDIFGDLFGGGSRSRRANNGPMKGANLRARVNITFEEAVFGCEKELEIVLKDECTTCHGTGAKPGTSPVTCPKCHGEGQVVYTQQSMFGMVRNVQTCPDCHGSGKIIKDKCTSCRGTGYTSSRKKIQVSVPAGIDNGQSIRIREKGEPGTNGGPRGDLLVEVNVARHPIFQRQDMNIFSTAPLTYAQAALGGTVRINTVDGEVEYEVKPGTQTDTRIRLKGKGVPSLRNKNVRGDHYVTFVVQVPTNLNEEAKEALRKFDEACGNRPKSKDSDDFEKPEKKKKSFMDKLKETFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZVU4</accession>
    <name>A0A173ZVU4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized metal-binding protein conserved in archaea</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052516.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79720">
        <property type="protein sequence ID" value="CUN79720"/>
        <property type="gene ID" value="ERS852478_01089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014997">
        <property type="entry name" value="DUF1847"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08901">
        <property type="entry name" value="DUF1847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN79720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="212" mass="23663" checksum="EE3299BDDFD1B1C9" modified="2016-09-07" version="1">MKKEDMSCIDCAVKNCSKMDKTYPDFCLTTHMDEEVLNEAMECYNEDENRKVTIAAAEVEYENYCKHTRVEEIMDFAKKINAKKIGIATCVGLLKESRILADILRRHGFEVYGVGCKAGTQKKTSVGIPECCEGVGVNMCNPILQAKLLNKAKTDLNVVVGLCVGHDSLFYKYSEALTTTAVTKDRVLGHNPVAALYTADSYYSKLKKCEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A6H4</accession>
    <name>A0A174A6H4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable cation-transporting ATPase F</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ctpF</name>
        <name evidence="6" type="ORF">ERS852478_01185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381066.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83095">
        <property type="protein sequence ID" value="CUN83095"/>
        <property type="gene ID" value="ERS852478_01185"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="671"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="701"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="788"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN83095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="844" mass="93536" checksum="257644839BBAF8A8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A7H5</accession>
    <name>A0A174A7H5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluD_2</name>
        <name evidence="5" type="ORF">ERS852478_01225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN84601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199971.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIOZ010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84601">
        <property type="protein sequence ID" value="CUN84601"/>
        <property type="gene ID" value="ERS852478_01225"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="116"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN84601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="349" mass="38870" checksum="360DC0D136FEA49B" modified="2016-09-07" version="1">MERYLEFRIDEQTTELKMDAFLKKNAGLTKRQISQAKFRPDGITRNGVRCRVTETIYPGDVIRVCLEEAGTASAHLENYNDGIKSKDLSDFHSNRASAPVSETSFSLNILYEDTDILAVDKPAGMVTHPTGMHYTDSLSNLVAGYFREKNEQVCVRPVGRLDQETSGIVVFAKNQVAASRLQSVKSPCKIHKQYLAAVSGTLPVDMPGVWHTLDLPLMQDPENHLKMKTAADLSLHSSALSGKIKTAVTHYHTLFSSQDWSLITLKLDTGRTHQIRVHMASTGHPLLGDTLYHSDDKISSCASFSRAALHAWKVSFQHPFRDEMLLLEAPLPFDFRELVSLSGSDLLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AFB8</accession>
    <name>A0A174AFB8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199982.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86370">
        <property type="protein sequence ID" value="CUN86370"/>
        <property type="gene ID" value="ERS852478_01243"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN86370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="287" mass="32759" checksum="0189D2627D4FBA68" modified="2016-09-07" version="1">MSIYDVFSGGNRPFDKEEWAAAKQAQRKEAYELIDNTCSEMMASGDSFRQYLDVQGCFDRYSVANAILVSAQMPEATQLKEYSKWKANRVYVNKDAQKIIILEPSKEYTREDGTKGVSYNAKVVYDISETSAKDRQQEQEPKSMRELVSALIDASPVSCVPVGELELPAYYDSSQQTIFVKKGLSEEVLFMSMAKEVSAAVYDFKYNESRDVSDFKSFCVAYMVSSRYGMDTRGFDFSRLPREYAEMDTQAFKGELGTMRDVLGEIQSDMYKSMEKNKPAKNKEQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AN48</accession>
    <name>A0A174AN48_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug-efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mdtK_3</name>
        <name evidence="2" type="ORF">ERS852478_01355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90181">
        <property type="protein sequence ID" value="CUN90181"/>
        <property type="gene ID" value="ERS852478_01355"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN90181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="469" mass="52202" checksum="148EA07F870F16CF" modified="2016-09-07" version="1">MERTKERSSFRKKFIGDRKFYMMVLAVAVPIMIQNGITNFVSLLDNIMIGRIGTEQMSGASIVNQLIFVYNLCIFGGVSGAGIFTAQYFGQKDHEGVRQTFRYKFWMAMILTIGTILLFLTVGENLISMYLQGEGTAQQIADTLKYGKQYLDIMLLGLPPFMMVQIYSSTLRECGETVLPMKAGVVAICVNLLFNYLLIYGVFFFPRLGVRGAAIATVLSRYVEAAIVIGWTHRHTEKNAFAKGLYSTLKVPANLTKKILVKGTPLLFNETLWASAMAMLTQCYSIRGLNVVASLNISNTINNVFNIVFIALGDSVAIIVGQLLGAGDMKKARDTDNKMIAFSVMCCTCVAMVMFVMAPLFPMLYNTNDEARELAKYLIMLTAFFMPQNAFLHATYFTLRSGGKTIITFLFDSVFIWCVSVPIAFVLSRYTGIHVLVIYACVQLADLIKCVIGFVLVKKGVWLQNIVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AND1</accession>
    <name>A0A174AND1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA polymerase III PolC-type</fullName>
            <shortName evidence="11">PolIII</shortName>
            <ecNumber evidence="11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">polC</name>
        <name evidence="15" type="ORF">ERS852478_01319</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DNA polymerase type-C family. PolC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200010.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88985">
        <property type="protein sequence ID" value="CUN88985"/>
        <property type="gene ID" value="ERS852478_01319"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00356">
        <property type="entry name" value="DNApol_PolC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028112">
        <property type="entry name" value="DNA_PolC-type_N_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006308">
        <property type="entry name" value="PolC_gram_pos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044923">
        <property type="entry name" value="PolC_middle_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14480">
        <property type="entry name" value="DNA_pol3_a_NI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01405">
        <property type="entry name" value="polC_Gram_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 11 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="14">
        <location>
            <begin position="376"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease" evidence="13">
        <location>
            <begin position="468"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="193"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUN88985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1496" mass="169562" checksum="ED4E8423CBE6F005" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B0T6</accession>
    <name>A0A174B0T6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200069.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93380">
        <property type="protein sequence ID" value="CUN93380"/>
        <property type="gene ID" value="ERS852478_01414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN93380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="101" mass="11174" checksum="A0CF5C669A29A460" modified="2016-09-07" version="1">MRLIDADKLILHLNDYALQESPSDVESAGDRKVSRAVYKAITDCIRAVDEQPTAFDLDKVVEQLKTKKTRTAALQKASEYFEGETDAFEVAIKIVKGGGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B184</accession>
    <name>A0A174B184_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200070.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93405">
        <property type="protein sequence ID" value="CUN93405"/>
        <property type="gene ID" value="ERS852478_01415"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN93405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="94" mass="10728" checksum="86127D9F26036A35" modified="2016-09-07" version="1">MKYPEEMYIDSQIFAGDMDGSESNLTEKVVKIRNSRLCCVCEKQVPKGERMLNQKAIVEGQGWRSCYICLPCVENWLEESGQVEDGGVNERNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B4K8</accession>
    <name>A0A174B4K8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein conserved in bacteria (DUF2313)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200100.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94666">
        <property type="protein sequence ID" value="CUN94666"/>
        <property type="gene ID" value="ERS852478_01456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018755">
        <property type="entry name" value="Phage_Mu_Gp48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10076">
        <property type="entry name" value="DUF2313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN94666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="252" mass="29362" checksum="7223E97B618BAEC3" modified="2016-09-07" version="1">MHIDNIDLEHFPTNEVAQRLLTYVTRGWYDKSYVGKWIYEVIGLELETASRRIDEAQKQAFPETAAWGMYLHEFMYGIPIDRTKDIDDRRKAVVNRRDRTTRSSITPYRLENIIQTVFGLSASVSEQVEKYVFGIDLLIGADYPIYSVDVLLEYIRKIKPSHLSMQARYVIEAAICSERERVLFPALDIGMQHVWTERFSVPSVEVKCEITEKLPVGMTGNVMIYKNLNQWNGEYKWDGTIKFDTEVTTEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B5H4</accession>
    <name>A0A174B5H4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_00974</name>
        <name evidence="3" type="ORF">ERS852478_01504</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993848.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96351">
        <property type="protein sequence ID" value="CUN96351"/>
        <property type="gene ID" value="ERS852478_01504"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YW0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021338">
        <property type="entry name" value="DUF2953"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11167">
        <property type="entry name" value="DUF2953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN96351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX63488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="342" mass="39488" checksum="6345E59EDCDBC786" modified="2016-09-07" version="1">MLHILWLILKFILIILGILLGLLLLAVLLVLFCPVRYKASAVKAEGGWKQTEGEGIVSWLFHGISLRAEWKDQQMEISFHLFGIPVDKLLKKRQEKRAVTKKSGKNPEKSGAEKVSVSGTDGNREEEHKKSVVDHPKSENMETEDLKTDRNSASDTSADTERIRNSQISGQQELNADDTDQNSLKKRQFFIKRIYDRIRNIFQLIRTKLQNIRRTFGKIKKNVSWWKAFIEHPRVTAARKLVWKHGKFLLKHIFPTRIEGQVTFSFEDPALTGAALAVLGMTIPFHKNCIQINPRFDSENYLYGNIRAKGRIYGFVPVRAAVSIYFNKNIKYVIKRWKTRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BN48</accession>
    <name>A0A174BN48_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA interferase</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mazF</name>
        <name evidence="4" type="ORF">ERS852478_01640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PemK/MazF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057333.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02003">
        <property type="protein sequence ID" value="CUO02003"/>
        <property type="gene ID" value="ERS852478_01640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO02003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="121" mass="13594" checksum="BA094E77A9AE7FAB" modified="2016-09-07" version="1">MTIRRGDILWADLGMFPTTSVQGGVRPVIVVSNNKANTYSSVITVVPLTSRIYKKRYLPTHVFISKYDMTGIRKGSLALAEQVMSISTKCIIEKCGRVNKWSLDRVLKAVRIQMGMNESEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BPS3</accession>
    <name>A0A174BPS3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yjbR</name>
        <name evidence="1" type="ORF">ERS852478_01625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_024720756.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01566">
        <property type="protein sequence ID" value="CUO01566"/>
        <property type="gene ID" value="ERS852478_01625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35145">
        <property type="entry name" value="PTHR35145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO01566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="124" mass="14320" checksum="52FEAF3019A081BD" modified="2016-09-07" version="1">MKKEEIFEYVQKQYGTMPEYLWSKLSDSAVLRHKNGKWYAVIMTVEKSKLGLEGNDLVDIMDVKCNPEMTSMIIQTYGFLPGYHMDKQHWITILLDGSVSEAKILDFLDMSYDLIDGADGKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C214</accession>
    <name>A0A174C214_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Making large colonies protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mlc_2</name>
        <name evidence="4" type="ORF">ERS852478_01765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional repressor of xylose-utilizing enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200245.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06867">
        <property type="protein sequence ID" value="CUO06867"/>
        <property type="gene ID" value="ERS852478_01765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO06867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="407" mass="45454" checksum="1400B8BA11D86039" modified="2016-09-07" version="1">MEMDSILENRKNYQRNKMLSVIRLHENISRNDVKKITAYSMTTVLSTIDELIQEGLVYEESCNDSRVGRKPVWLRINPEGGYFLGVEFNRNAIHCVALDFTGKLIYDAERNIETSEKTADQVLELVKKMIYDGIAFLGEKSKKVIGIGIGIPGYSDANRGIAISYSHLKDWKNIPVKDILEKEFHVTCYMDNNVNVMIFAYKWLVYGGKCEDMLFVSIRTGARVIPIINNQPVRGTCGYSGELGHVKVSGGSRICSCGRYGCLNSEISDVAIVNKIIDGIKVGRFREIAEAVQGDMDKVTMMSFINSVREGHADSLKLLDQVKGFIADTLSMLVNIFAPRKIVLFGELAELGDILLDGVRERVSENIIKENSNGLKIMASEFGRNLGAMGAAAMVMQNAFEFLEEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C5C1</accession>
    <name>A0A174C5C1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribose operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rbsR</name>
        <name evidence="5" type="ORF">ERS852478_01811</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200290.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08344">
        <property type="protein sequence ID" value="CUO08344"/>
        <property type="gene ID" value="ERS852478_01811"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO08344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="352" mass="39204" checksum="BBE0F5AB5A1B88A8" modified="2016-09-07" version="1">MTLKEIARQANVSVSTVSRVINQKNTKAASPEVQERIWKIVRKSGYTPNATARSLKLGQKAQIQNTTPKSIACIYARSNSAVSDPFFSQIAKAIEQEAFKSNYFIRQSFTAMDIANPDMARQLAQFPVDGIVILGRYEKQLLRFFTQNYKNVIYTGLNPMGTQYDQVVCDGSDISYSALSYLVELGHTKIGYVGEQNNEVRFSGYKDALAKLGLPFLQKNTSNVHLSADGGYKGANILMHNKADISAIFCANDTTALGVIHALKEKNFRIPEDISVISVDDIETAQYLSPMLTTVHIPLEELGRITAKTLIDRINGGHRLPMRISLPFYIAKRDSCGKLNRRRKTFASLPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CAG7</accession>
    <name>A0A174CAG7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferritin</fullName>
            <ecNumber evidence="5">1.16.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftn</name>
        <name evidence="7" type="ORF">ERS852478_01858</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Iron-storage protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide</text>
            <dbReference type="Rhea" id="RHEA:11972"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:78619"/>
            <dbReference type="EC" id="1.16.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the ferritin family. Prokaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10541">
        <property type="protein sequence ID" value="CUO10541"/>
        <property type="gene ID" value="ERS852478_01858"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01055">
        <property type="entry name" value="Nonheme_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041719">
        <property type="entry name" value="Ferritin_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0409">Iron storage</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="6">
        <location>
            <begin position="57"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO10541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="216" mass="24991" checksum="7EA3FE0E80D6A3EB" modified="2016-09-07" version="1">MPKYAEEILAAVTELQQHLTAEQVFLEMKREHPSIALGTVYLPPAGSRKKTILWGRSIMNANVSKLLNEQINKEFYSAYLYLDFANYYAAVGLDGFENWYRVQAQEERDHAMLFYQYLQNNGEGVTFEAIAKPEWERGDNMTPLKKALEHEKLVTASIDAIYAAAYEVRDFRTMQMLDWFIKEQGEEEKNAADLITKMELFGGDSKGLYMVNYYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CDI2</accession>
    <name>A0A174CDI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-flavin oxidoreductase</fullName>
            <ecNumber evidence="2">1.6.99.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">frp</name>
        <name evidence="2" type="ORF">ERS852478_01890</name>
        <name evidence="4" type="ORF">GT712_19110</name>
        <name evidence="3" type="ORF">GT728_21485</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.6.99.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000133">
        <property type="protein sequence ID" value="MZL35660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000069">
        <property type="protein sequence ID" value="MZS91088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053636.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000133.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11492">
        <property type="protein sequence ID" value="CUO11492"/>
        <property type="gene ID" value="ERS852478_01890"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO11492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL35660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS91088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="166" mass="18909" checksum="CCC47F568E1F5FBE" modified="2016-09-07" version="1">MNSIFHRISVRKYEDKPVEKEKIMEILKAGMQAPSACNQQPWEFYVVTDKEKIQKLSKVTPYTGCAAGAPAVIVPVYHTEGLVAPSFAQIDMSIAQENIWLETDTLGLGGVWFGIAPVEEHMEKVHRLLDLPENVKVFSMFALGYPAETRPQQDRFYPDRIHFIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CLZ3</accession>
    <name>A0A174CLZ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIR domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13897">
        <property type="protein sequence ID" value="CUO13897"/>
        <property type="gene ID" value="ERS852478_01965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO13897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="247" mass="29357" checksum="ABF66ADDBA2EEF28" modified="2016-09-07" version="1">MLFFCFSSKDRHSIVESILFHLTNYGLPVWYDRHKMLLGDERDNKNFDEGVKACNYSIIILSANTIASECANEEIDLIYQRYKQHKMYVFPIFFNIKASQLPEKYCWMKRLVYKELTVANDSRSACNHIICKVTLDELQKYKIKTINEYLKLYKNNKAFSYLTELIDSYCKISDENHNAQIALLYAGCLYIKEKYNCCLEIPEFYYKGIQRLFEETRLNLPIDLRETLIFERLFLLLFNAAIFGYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CN34</accession>
    <name>A0A174CN34_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS200 like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transposase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02179</name>
        <name evidence="2" type="ORF">ERS852478_01954</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993982.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13569">
        <property type="protein sequence ID" value="CUO13569"/>
        <property type="gene ID" value="ERS852478_01954"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="16"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO13569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="139" mass="16448" checksum="308729C8DB620686" modified="2016-09-07" version="1">MFNINNNELSYGRGYVYSLQYHLVWCTKYRKKVLKDGIDAECKEMLCDLAEEYKFQILAMEVMPDHIHLLVDCRPQFYISDMIKIMKGNIARQMFLAHPELKKELWGGHLWNPSYCAVTVSDRSREQVCSYIEGQKEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D1U3</accession>
    <name>A0A174D1U3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphopyruvate hydratase</fullName>
            <ecNumber evidence="5">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">eno_2</name>
        <name evidence="11" type="ORF">ERS852478_02072</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO18055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18055">
        <property type="protein sequence ID" value="CUO18055"/>
        <property type="gene ID" value="ERS852478_02072"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_C" evidence="10">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO18055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="269" mass="29521" checksum="96DC8D7AB469A6F2" modified="2016-09-07" version="1">MPTGAENMEQAIRMCAEVYQFLRIILKQKGLSTAVGDEGGFAPDLSDSESVLEVILEAVKKAGYEPGKDISIAIDAAASELYDEERGVYVFPGEGKMKGEEVLRDSGEMIEYYEKLTEKFPIVSIEDGLEEDDWEGWKQMTKRLGDKIQLVGDDLFVTNIKRLACGIKLGAANAILIKLNQIGTLSEALDAVEMAQKSGYRAVISHRSGESEDSFIADLAVATGAGQIKTGAPCRSDRNAKYNQLLRIHEALGELAVYENPFKENEKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D2G7</accession>
    <name>A0A174D2G7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding domain, excisionase family</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02112</name>
        <name evidence="3" type="ORF">GT712_19615</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000084">
        <property type="protein sequence ID" value="MZS91175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003864535.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000149.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19912">
        <property type="protein sequence ID" value="CUO19912"/>
        <property type="gene ID" value="ERS852478_02112"/>
    </dbReference>
    <dbReference type="GeneID" id="61851086"/>
    <dbReference type="GeneID" id="65244684"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO19912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS91175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="58" mass="7039" checksum="A97127FBD2A600AB" modified="2016-09-07" version="1">MSEKRCYTVQELQEILGVSRPTIYNLLKKKEFRWIQLDGGKYRISKKSFDDWLDNLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7Q5</accession>
    <name>A0A174D7Q5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Uncharacterized N-acetyltransferase YjaB</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjaB_2</name>
        <name evidence="2" type="ORF">ERS852478_02118</name>
        <name evidence="3" type="ORF">GT712_11565</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053942.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20085">
        <property type="protein sequence ID" value="CUO20085"/>
        <property type="gene ID" value="ERS852478_02118"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO20085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS89692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="141" mass="16694" checksum="FDACD8DFF1052F2F" modified="2016-09-07" version="1">MIRKLLNGDIDRVADIWLKTNLKAHYFISNQYWKSNYELVKEMMSQYEVYVFEADKMIQGFVGLNDKYIEGIFVSDEMQSCGIGKLLLDYVKDKKVSLRLNVYQKNARAISFYQREGFIIQCEGLDEATGEKEYTMLWKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DBF2</accession>
    <name>A0A174DBF2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sigma_reg_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379892.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21629">
        <property type="protein sequence ID" value="CUO21629"/>
        <property type="gene ID" value="ERS852478_02168"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025672">
        <property type="entry name" value="Sigma_reg_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13791">
        <property type="entry name" value="Sigma_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma_reg_C" evidence="3">
        <location>
            <begin position="254"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO21629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="425" mass="49597" checksum="5B9BBE64D2B25F0C" modified="2016-09-07" version="1">MTYRELLNLYKQGKLDDVRKKEVEASIEKQDAISEFLYEEGEIPEFSDLESENAENPENEEWLSGQKNNQKDEINRQFIKEIRWSIRKTFIKMGIIVGVAVLVIVLCAVFILPKAVSDFYYNPNEVVGKYEEMTTTRMDLDLSVYSELFLAGNHRSQVSAVSRGYGEYDIIIPQTFSWTGKFTSVSGRLVRGNLTFYDNNILSRPLMQFYLPGDTTAWEAWEVDENGKETKVDTEMRKEESVQDSKDAIAEYNDNDWYLAYVSINDIVDYRDFIEWYQKLSDDKELEWGELWCAVHTEDADGYCVEPNIGFCPYPSGMSMNWDREKYPYLSLLDNTDICHDVDVTDEEIMQTHFISMLSYIQDYDDIISMMGQTTDSPNRYQDMINYVKKNGLKIHGFAVYAKKKNLLELYKQDMVSYVQTILQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DVJ4</accession>
    <name>A0A174DVJ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphatidylglycerophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pgsA_2</name>
        <name evidence="19" type="synonym">pgsA</name>
        <name evidence="18" type="ORF">ERS852478_02340</name>
        <name evidence="19" type="ORF">ERS852523_01079</name>
        <name evidence="20" type="ORF">GT728_07815</name>
    </gene>
    <organism evidence="18 21">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 21 22" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 21">2789STDY5834863</strain>
            <strain evidence="19 22">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="20 23" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 23">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein catalyzes the committed step to the synthesis of the acidic phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP26634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000014">
        <property type="protein sequence ID" value="MZL33112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704529.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1059"/>
    <dbReference type="EnsemblBacteria" id="CUO28065">
        <property type="protein sequence ID" value="CUO28065"/>
        <property type="gene ID" value="ERS852478_02340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26634">
        <property type="protein sequence ID" value="CUP26634"/>
        <property type="gene ID" value="ERS852523_01079"/>
    </dbReference>
    <dbReference type="GeneID" id="66494228"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006655">
        <property type="term" value="P:phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CUO28065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CUP26634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="MZL33112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="179" mass="20232" checksum="C1706DB717989468" modified="2016-09-07" version="1">MNTPNKLTVARMILVPFLVLFMLTDLGGEANRYIALAIFVVASVTDWFDGKLARKYNLVTNFGKFMDPLADKLLVCSAMICFIELEKLPAWFVIIIIGREFIISGFRLIAAENGVVIAANYWGKFKTVSQMIMIILLLIDLGGVFDILEQIFIWLSLALTVISLITYIWQNRSVLSMQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E2E8</accession>
    <name>A0A174E2E8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO31963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31963">
        <property type="protein sequence ID" value="CUO31963"/>
        <property type="gene ID" value="ERS852478_02448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043733">
        <property type="entry name" value="DUF5677"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18928">
        <property type="entry name" value="DUF5677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO31963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="326" mass="38148" checksum="137C1E4B402A71B6" modified="2016-09-07" version="1">MEDNYLKLFGNMFYNIKEDQDNKKIIEEASEVLASIIIKYGELINEITARTSAQDEFVDTVICLFLRKIMEQLDALNILIDAGAFSPMQVIVRTLLENTVGLEFILKEDTRKRAAAYYLEQHYKEIETGEKLFARKSEKSKNAIKLLGEAQFTEDSKRFQRKKDAFQHLIDTNELFKEVADAREKAIESKRKYWKKKKRKNINKIHIQWYEIGTNVQNFREMMRETGHEKYYEGIYGGLSYEIHALNAARAIQAVADGLYLQRIRNPQNGGNIFAFVCDFSLIALDKVYKYLDDDEAKRAEFKRYVMDCQKKKVHIIATMDQINIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E5S2</accession>
    <name>A0A174E5S2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX amino terminal protease self-immunity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059639.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33272">
        <property type="protein sequence ID" value="CUO33272"/>
        <property type="gene ID" value="ERS852478_02500"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO33272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="216" mass="24592" checksum="7F4908A3FF763393" modified="2016-09-07" version="1">MIPALYFYRRDKVRRIAGGLIPAQKKVPLSLLEIILLLLAGAGLAQYGNFLMAILQSFINSSAYQESMTRITEGKSLLMMIFWMGIIAPAAEEMIFRWLIYLRLRDWLKMPVAAVISGLIFGIYHGNIVQGIYASILGTAFAWILEMSGNTYSSMLLHMGANIWSLLISEYALDLYSMKYGVQILILIYLILLISVVYCLTHFEKMCSIRKKKRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ENE1</accession>
    <name>A0A174ENE1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino-acid carrier protein AlsT</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Na+/alanine symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">alsT_1</name>
        <name evidence="9" type="ORF">BWLFYP14_00923</name>
        <name evidence="8" type="ORF">ERS852478_02660</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993327.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38767">
        <property type="protein sequence ID" value="CUO38767"/>
        <property type="gene ID" value="ERS852478_02660"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO38767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX63445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="120" mass="12728" checksum="88FD5D845CAD86AE" modified="2016-09-07" version="1">MLILLVGTGIFLTVRTRFLTWRNLGYALKSTLSKEARTKSRGQGDVSPFSALTTSLAATIGTGNIVGVATAMVSGGPGALVWNFSDIANALMAIPNLICMLLLSGEIAKDVKEFQPEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EVT6</accession>
    <name>A0A174EVT6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjO_8</name>
        <name evidence="7" type="ORF">ERS852478_02696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379940.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40140">
        <property type="protein sequence ID" value="CUO40140"/>
        <property type="gene ID" value="ERS852478_02696"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="67"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO40140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="284" mass="31611" checksum="7307B8853AD42B9A" modified="2016-09-07" version="1">MVGKTIKKWWPIFVLPTLAAFIIGFLWPFIWGIYLSFCKFTTVQDVTFVGFSNYQKILLDNTFSHAFWLTVIFAFISSILINVLAFAIALALTKGFKGTNAFRTVFFMPNLIGGIVLGYIWQTLLNGLLSKWGQPLLALSAKNGFIGMLILLCWQQIGYMMIIYVAGLNNVSPDLIEAAQIDGATSRQILFKIKLPMIMPSVTICTFLTLTNGFKMFDQNLSLTGGDPAKQSQLLALNIYDTFYARSGPQWKGIGQAKAVVFFILVVAIALIQLKATSSKEVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F2S3</accession>
    <name>A0A174F2S3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Sulfate adenylate transferase</fullName>
            <shortName evidence="2">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">cysD</name>
        <name evidence="4" type="ORF">ERS852478_02819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of CysD, the smaller subunit, and CysN.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43857">
        <property type="protein sequence ID" value="CUO43857"/>
        <property type="gene ID" value="ERS852478_02819"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00064">
        <property type="entry name" value="Sulf_adenylyltr_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02039">
        <property type="entry name" value="CysD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="3">
        <location>
            <begin position="98"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO43857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="370" mass="42808" checksum="18DAC15450D81B40" modified="2016-09-07" version="1">MKNALRKMCVTIYGRFCSDEGVVAGYDNRIRTKYTAKWGVQIAGMIFQTRSSVFAQVRKDSEYKQTEEDNAMSNLSHLDALEAEAIYIMREVAAECEKPVMLYSIGKDSSVMLHLAMKAFYPEKPPFPFLHIDTTWKFHEMIEFRDRIAKENGIDMLVYTNEEGVKAGINPFDNGSAYTDIMKTQALKQALTKYGFTAAFGGGRRDEEKSRAKERIFSFRNSAQAWDPKNQRPEMWKLYNTKIQKGESMRVFPISNWTEKDIWQYIQRENIEIVPLYFAKERPVIYRDGNIIMVDDDRLKLRPGEKIENKKVRFRTLGCYPLTGGIESEADTLDEIIDETLSAVSSERTSRVIDHEAAGSMERRKREGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FCW8</accession>
    <name>A0A174FCW8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase-like superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201021.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48023">
        <property type="protein sequence ID" value="CUO48023"/>
        <property type="gene ID" value="ERS852478_02948"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="157"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO48023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="833" mass="95345" checksum="911D96053A1AC2D3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FF67</accession>
    <name>A0A174FF67_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">30S ribosomal protein S1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">S1 RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhgF</name>
        <name evidence="2" type="ORF">ERS852478_02960</name>
        <name evidence="3" type="ORF">GT728_07340</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000013">
        <property type="protein sequence ID" value="MZL33019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380016.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48361">
        <property type="protein sequence ID" value="CUO48361"/>
        <property type="gene ID" value="ERS852478_02960"/>
    </dbReference>
    <dbReference type="GeneID" id="66493661"/>
    <dbReference type="eggNOG" id="COG2183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="646"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO48361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="719" mass="80037" checksum="D70AA07189B0DE45" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FIM0</accession>
    <name>A0A174FIM0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_03009</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201071.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50114">
        <property type="protein sequence ID" value="CUO50114"/>
        <property type="gene ID" value="ERS852478_03009"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="445"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO50114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="548" mass="63531" checksum="AE383079FEDA938A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FIP0</accession>
    <name>A0A174FIP0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0735 ACT domain-containing protein ERS852478_02965</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0735 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201035.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48499">
        <property type="protein sequence ID" value="CUO48499"/>
        <property type="gene ID" value="ERS852478_02965"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00707">
        <property type="entry name" value="UPF0735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008310">
        <property type="entry name" value="UPF0735_ACT_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025624">
        <property type="entry name" value="ACT_PheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="2">
        <location>
            <begin position="75"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO48499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="151" mass="16995" checksum="AF7CD30F70D41163" modified="2016-09-07" version="1">MQKPVTEKKKYFVVRERAVPEVLLKVVEAKKLLDSGKVDTVQDAAERIGISRSSFYKYKDDIFPFHEETRGKTITFIIQMDDEPGLLSVVLQTIARFHGNILTIHQSIPINGIATLTLSVDILPGEGDAEAMVETIEQNEGIHYLKILGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FR05</accession>
    <name>A0A174FR05_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03070</name>
        <name evidence="3" type="ORF">GT712_15170</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO52151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000035">
        <property type="protein sequence ID" value="MZS90373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52151">
        <property type="protein sequence ID" value="CUO52151"/>
        <property type="gene ID" value="ERS852478_03070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="137"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO52151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="336" mass="38650" checksum="5CE31969E1EB3EFD" modified="2016-09-07" version="1">MLDTAEKNKIKPDTILKNFWRDNRHFADLFNAVFFNGEQVLKPQDLTEADTDVSSMLKFNGHAETVQKILDVVKKTAYGVDFVLWGLENQAKIHYAMPLRHMVGDAFSYMKEYDEIAAVNKKNGDFHSADEFLSGFKKTDRLHPVISLCVYYGESEWDGPFSLKDMLEIPEKIESLVSDYRMNLVQVRSSGELCFSDPDVNMVFDVSRLIYARDYTKINEVYRDHNIPADLGLVIGAITESQKLIDHALESEQKGGQINMCNALEELRQEGVEEGRQEGRQEGRQEGRWEGILEGIRATVRTCRNFNISETDTVRNIMNEFSLSQEEAVNYVKKYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FTA6</accession>
    <name>A0A174FTA6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">plsC_2</name>
        <name evidence="7" type="synonym">plsC_1</name>
        <name evidence="7" type="ORF">BWLFYP14_00773</name>
        <name evidence="5" type="ORF">ERS852478_03068</name>
        <name evidence="6" type="ORF">GT728_15245</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="2">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO52098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000043">
        <property type="protein sequence ID" value="MZL34511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000020">
        <property type="protein sequence ID" value="VUX63081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379927.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52098">
        <property type="protein sequence ID" value="CUO52098"/>
        <property type="gene ID" value="ERS852478_03068"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="5"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="4">
        <location>
            <begin position="73"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO52098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL34511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX63081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="248" mass="28405" checksum="87BAC57B39B284A0" modified="2016-09-07" version="1">MIRFILVCIVVIGYLILSIPILLVEWIIGRFSPEKKDISSLRIIQAVFRFILKITGAKITVIGEENVPKDTPVLYIGNHRSYFDILLTYSRCPIRTGYIAKKEMEKIPLLSTWMRYLHCLFLDRKDIKQGLKTILTAVDKVKSGISICIFPEGTRNRNKDELDMLPFHEGSFKIATKANCPIIPIAISNSANIFEAHFPKISPAKVVVEYGKPIYPDELSKEDKRHVGEYTQNVIREMLIKNKPLTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FTL2</accession>
    <name>A0A174FTL2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">N-acetylmuramoyl-L-alanine amidase LytC</fullName>
            <ecNumber evidence="4">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lytC_3</name>
        <name evidence="4" type="ORF">ERS852478_03072</name>
        <name evidence="5" type="ORF">GT712_19525</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.28" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO52198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000079">
        <property type="protein sequence ID" value="MZS91160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060436.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000100.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52198">
        <property type="protein sequence ID" value="CUO52198"/>
        <property type="gene ID" value="ERS852478_03072"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018337">
        <property type="entry name" value="Cell_wall/Cho-bd_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19127">
        <property type="entry name" value="Choline_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252805" evidence="2">
        <location>
            <begin position="32"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="3">
        <location>
            <begin position="198"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO52198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS91160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="322" mass="36076" checksum="1B83BE47FB5FE58E" modified="2016-09-07" version="1">MKKRKSCFIWLLCILLLVTALPSVNFTDVQAASVSSTFTGWKTFGGKKYYYKNGKKLTDLHKIGKYYYCFAADGTMLTGWHRIHNRFRYFGKQTGRMRINQTVNRRKINSKGVWTPVIVLDPGHSAVVAGGYEPLGPDSSQLKEKDTSGTQGVATGVEEYKLNLSIGLQLRTLLQKRGFKVIMTRTNSKVALSCIDRAKVANKANADAYIRIHANGSDNSSISGALTICTTRNSPYISSMYRKNKALSEAVLNAYVSATGCRKEYVWETDSMTGNNWSKVPTTIIEMGYMSNPSEDRRMQQSSYQKKMVRGIANGIENYLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FTT0</accession>
    <name>A0A174FTT0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="9">CMK</shortName>
            <ecNumber evidence="2 9">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">ispE</name>
        <name evidence="12" type="ORF">ERS852478_03065</name>
        <name evidence="13" type="ORF">GT728_15260</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 9"/>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO52019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000043">
        <property type="protein sequence ID" value="MZL34514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379930.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52019">
        <property type="protein sequence ID" value="CUO52019"/>
        <property type="gene ID" value="ERS852478_03065"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="10">
        <location>
            <begin position="84"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="11">
        <location>
            <begin position="198"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO52019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL34514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="292" mass="31924" checksum="1292C1C223F23BDE" modified="2016-09-07" version="1">MRLRALAKINLGLDILRKREDGYHEVRMIMQTIQMYDVLEMKRVRKPGISLSVNYSYIPNDERNLVYKAAKLLMDEFQVKGGVDIHLEKFIPVAAGMAGGSSDAAAALVGINRLFKLGLSQKELMDRAVNIGADVPYCVMRGTALAEGIGEKLTRITQVPDCFVLIGKPGINVSTKAAYESLQLDKISSHPDIDGMIGDIERGDLLAMTQKMGNVFEPGIIEKYPVIGEIKALMESHGALKAMMSGSGPTVFGIFDDREKMEAAAEVLRESRLAKTVFATEVTKAGGNTNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FX28</accession>
    <name>A0A174FX28_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted P-loop ATPase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53997">
        <property type="protein sequence ID" value="CUO53997"/>
        <property type="gene ID" value="ERS852478_03127"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007936">
        <property type="entry name" value="VirE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05272">
        <property type="entry name" value="VirE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO53997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="442" mass="51304" checksum="BDFB07A2664C7BB8" modified="2016-09-07" version="1">MQPPQSIEEIKAGLETTEKGGVRQSIRNCLTVFQRDPLLSGAIAYNILTDRKDIIKPIGFHRESTALNDTDMKYLLLYLEETYGLTNEKKIDNAIGIVANENKYHPIRDYLNTLVWDGTERIRFCLRHFLGADADDYTYEALKLFLLGAISRAFQPGCKFEIMLCLVGGQGAGKSTFFRLLAVRDEWFSDDLRKLDDDNVYRKLQGHWIIEMSEMMATANAKSIEEIKSFLSRQKEVYKIPYETHPADRPRQCVFGGTSNALDFLPLDRSGNRRFIPVMVYPEQAEVHILEDEAASRAYIEQMWAEAMEIYRSGRFKLAFSPTMQRYLKEHQRDFMPEDTKAGMIQAYLDKYTGSMVCSKQLYKEALNHTFDEPKQWEIREINEIMNQCITGWRYFPNPRMFSEYGRQKGWERENPATDSGNPSEKTMDGFVEVTEQMELPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FZI3</accession>
    <name>A0A174FZI3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Anaerobic benzoate catabolism transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055054175.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55091">
        <property type="protein sequence ID" value="CUO55091"/>
        <property type="gene ID" value="ERS852478_03161"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO55091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="118" mass="13447" checksum="98977DC840986A0B" modified="2016-09-07" version="1">MPIDDLTALGQKMREARKNKELTQQELADLSHVSVKQIANIEKGKMNPSYLILRALAKVLHISLDTLINPDVSLEDEGVNQMKMLYSSCPPEMRDTLLHHTQETVKELTELSEIFEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FZJ4</accession>
    <name>A0A174FZJ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator PadR-like family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, Acidobacterial, PadR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_00688</name>
        <name evidence="2" type="ORF">ERS852478_03151</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO54837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000015">
        <property type="protein sequence ID" value="VUX62939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201204.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000098.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54837">
        <property type="protein sequence ID" value="CUO54837"/>
        <property type="gene ID" value="ERS852478_03151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO54837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX62939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="174" mass="19933" checksum="41249DE45611C22C" modified="2016-09-07" version="1">MSSIDLVILGIVLEKPQSAYDIQKDVEYHHFPRWTKISVPSIYRKVLQLSEKGYLHSNIVKGDKFADKAIYSITDQGRAYFKELMAACAAGPVPLLFDFNVVITNLNKMDKAEALELVSTLRRSIQSSVEANEGYAREFADIPLVGRTIFEQQQLLYRALMEWLDHFEGQFLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G1G5</accession>
    <name>A0A174G1G5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_00857</name>
        <name evidence="1" type="ORF">ERS852478_03155</name>
        <name evidence="2" type="ORF">ERS852523_03528</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO54946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000053">
        <property type="protein sequence ID" value="CUP98914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000024">
        <property type="protein sequence ID" value="VUX63370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055153209.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54946">
        <property type="protein sequence ID" value="CUO54946"/>
        <property type="gene ID" value="ERS852478_03155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP98914">
        <property type="protein sequence ID" value="CUP98914"/>
        <property type="gene ID" value="ERS852523_03528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO54946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP98914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX63370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="73" mass="8395" checksum="4F0112113FE1072B" modified="2016-09-07" version="1">MLFLTDVDHVSFEKVKGARQNNLQSATVSLQVVIGLYKRKETAALKSKPPFHKARENMSAVRRLFFFCRRPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G8X2</accession>
    <name>A0A174G8X2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF2179 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein conserved in bacteria (DUF2179)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852478_03219</name>
        <name evidence="10" type="ORF">GT728_05030</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060604.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57350">
        <property type="protein sequence ID" value="CUO57350"/>
        <property type="gene ID" value="ERS852478_03219"/>
    </dbReference>
    <dbReference type="GeneID" id="66496190"/>
    <dbReference type="eggNOG" id="COG1284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="229"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO57350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL32582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="290" mass="31080" checksum="5D507D97F8B5EFEC" modified="2016-09-07" version="1">MKLVNGKRSQLLEYLMIIAGTGLMALAINSVFDASGMVTGGFSGIAIIIKAGSQGIIDGGIPLWVTNMGLNIPLFLIGWKINGFSFVKKALIGEIALSTWLAIEPVWNLAGNDLLLAALYGGVIQGVGIGLVFLGGGTTGGTDMMAAIIQKYLQHYSIAQIMQVIDAGVVLVGMYVFGIHKALYAIIAVYLVTKVSDSLIEGLKFSKAAYIITAKPKEIADMIMKDLDRGVTGISARGMYSGQDKLMLFCVVNKKEIVMLKEKVDEIDPEAFVIVTDAREVHGEGFIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GBV2</accession>
    <name>A0A174GBV2_9FIRM</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO59117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59117">
        <property type="protein sequence ID" value="CUO59117"/>
        <property type="gene ID" value="ERS852478_03281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO59117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="84" mass="9996" checksum="6FEDE4DB2F5E30CC" modified="2016-09-07" version="1">MRSRFRGKRKRSRQKELVEIQLRTLAMDYWSVLEYHIYTAWILKTKIQAVILIPACHWQIIIDSFSHQNLVQINNSVMEGCSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GC41</accession>
    <name>A0A174GC41_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria C-term(DUF2220)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_03479</name>
        <name evidence="2" type="ORF">ERS852478_03261</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO58626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705127.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000055.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58626">
        <property type="protein sequence ID" value="CUO58626"/>
        <property type="gene ID" value="ERS852478_03261"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024534">
        <property type="entry name" value="DUF2220"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09983">
        <property type="entry name" value="DUF2220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2220" evidence="1">
        <location>
            <begin position="149"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX67204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="326" mass="38785" checksum="1032D6387CC7C758" modified="2016-09-07" version="1">MKRISLDDLLHTRQDLDYQEQYEYIMKLLEKGQIKPVKASKSNGKKPALYREYWMVEEQKDYSNYIEEIKYTFSTMISVDYYLAHPDTYEKDRIWVLMLNEYLKKHADALLTAESLNERSFEIWHREKFLDREQGKKILKRCGLNVEALNVYRTTEPLSYYTHTRNTPQNILILENKDPFFSMRNYLLNGHTEIFGAEIGTLIYGAGKGIIRSFQDFDLCAEPYMKHPKNTIYYFGDMDYEGIGIYENLAEKFRSRWKIIPFVPAYQAMLGKAEQIIELPETKEHQNRNISTQFFSCFDEIMVKKMEAVLDKDRYIPQEILNTADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GDZ6</accession>
    <name>A0A174GDZ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acid-activated urea channel</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Urease accessory protein UreI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ureI</name>
        <name evidence="11" type="ORF">BWLFYP14_03502</name>
        <name evidence="9" type="ORF">ERS852478_03286</name>
        <name evidence="10" type="ORF">GT712_01240</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AmiS/UreI family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO59246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705095.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59246">
        <property type="protein sequence ID" value="CUO59246"/>
        <property type="gene ID" value="ERS852478_03286"/>
    </dbReference>
    <dbReference type="GeneID" id="66495411"/>
    <dbReference type="eggNOG" id="ENOG502ZC7C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003211">
        <property type="entry name" value="AmiSUreI_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038523">
        <property type="entry name" value="AmiSUreI_transpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02293">
        <property type="entry name" value="AmiS_UreI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO59246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS87747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX67227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="168" mass="18469" checksum="41709D268C43A68B" modified="2016-09-07" version="1">MLGVCLLFVGIVLINNGMCSLYNVDGKSTAIMNIFTGGLSLFINFVNLVQGNYYAAGTGLLFCFTYLFVALSKFLKASPIPFAWFSTFVAINAVIFGTIEGFTGSTALGITPDLRWAAIWYLWAILWGTAFVEDICGKKLGKFVPYLQVFEGIVTAWVPGVMMLLQIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GGR8</accession>
    <name>A0A174GGR8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61533">
        <property type="protein sequence ID" value="CUO61533"/>
        <property type="gene ID" value="ERS852478_03346"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO61533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="238" mass="27648" checksum="81857B35C7F90901" modified="2016-09-07" version="1">MSCDHIKDIKIQENAKRFLNNISNRLGEVFAEILKLQNPSDGKIDTSEVLYSVERNFRKELSKEISTVQLTKGNLKEPKTVVKVKGNSKKDKRQEKKKKKESQLKKIINRLTRKSKLEDGDQEKEVSLIPMKPEAVKRIVLREKELLQFDFTNVMEYAGETNCNISMVVIDGTGKPYEKEFNLGKNYREVMNIGQKKICKIEDNKIKSVSIMDGKIQLELKVTDYFNNSLKFMYYVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GK38</accession>
    <name>A0A174GK38_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylmalonyl-CoA carboxyltransferase 5S subunit</fullName>
            <ecNumber evidence="2">2.1.3.1</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Oxaloacetate decarboxylase subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02978</name>
        <name evidence="2" type="ORF">ERS852478_03392</name>
        <name evidence="3" type="ORF">GT712_15560</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.3.1" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO62992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000038">
        <property type="protein sequence ID" value="MZS90447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000072">
        <property type="protein sequence ID" value="VUX66702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704465.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62992">
        <property type="protein sequence ID" value="CUO62992"/>
        <property type="gene ID" value="ERS852478_03392"/>
    </dbReference>
    <dbReference type="GeneID" id="66494196"/>
    <dbReference type="eggNOG" id="COG5016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047154">
        <property type="term" value="F:methylmalonyl-CoA carboxytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO62992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="470" mass="52874" checksum="543FC5C59BD20AC5" modified="2016-09-07" version="1">MAELEKKPVKIVETILRDAHQSQIATRMTTEQMLPIVDKLDKVGYHAVECWGGATFDASLRFLHEDPWERLRKLRDGFKNTKLQMLFRGQNILGYRPYADDVVEYFVQKSAANGIDIIRIFDCLNDLRNLQTAVSAANKEKAHAQVALSYTLGDAYTLEYWTDIAKRIEDMGADSICIKDMAGLLLPNKATELVTALKETVKIPIDLHTHYTSGVASMTYLKAVEAGVDIIDTAMSPFALGTSQPATEVMVETFKDTPYDTGFDQKLLSEIADYFRPIRDEALDSGLLNPKNLGVNIKTLLYQVPGGMLSNLTSQLKEQHAEDKFYDVLEEVPRVRKDLGEPPLVTPSSQIVGTQAVFNVLMGERYKMVTKETKDILLGKYGATVKPFNPEVQKKCIGDEKPITCRPADLLDNELEKLESEMAQYKEQDEDVLTYALFPQVAMDFFKYRQAQKTKVDEKAADKKNGAYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GK44</accession>
    <name>A0A174GK44_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">ispH</name>
        <name evidence="6" type="ORF">ERS852478_03389</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO62904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201360.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62904">
        <property type="protein sequence ID" value="CUO62904"/>
        <property type="gene ID" value="ERS852478_03389"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO62904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="292" mass="32626" checksum="6D961C3BB4E52219" modified="2016-09-07" version="1">MKVKVAETAGFCFGVKRAVNKVYELIDTEQKPIFTLGPIIHNEGVVADLEARGVHVIAEADLDSPDDTLQNGTVVIRSHGVGKAIYDKLKEKNISYVDVTCPFVLKIHRIVEKESLAGNHIIIIGDKDHPEVQGICGWCQGPYTVIRNKEEAEVFVPPKGKKISIVSQTTFNYNKFKDLVEILCKKRYDNNVLNILNILNTICNATEERQREAKNIAGEVDTMLVVGGRHSSNTQKLFEICKKECGNTYYIQTPVDLDSEMFQCSSYVGITAGASTPNKIIEEVQEHVRIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GK55</accession>
    <name>A0A174GK55_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein involved in cytokinesis, contains TGc (Transglutaminase/protease-like) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO62381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62381">
        <property type="protein sequence ID" value="CUO62381"/>
        <property type="gene ID" value="ERS852478_03377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO62381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="215" mass="24805" checksum="C9DF2038246B56F5" modified="2016-09-07" version="1">MTARVEKLIRPAQKLSEWEKEKHVHDFICENIRYDKLKKSYSHEIIGPLGQGVGVCEGIAKAVKVLLDALGVWCVIAICGNNPETSEIRYDYFNLDDSQIFRDHEPLIAPAPHCGDHEHFYYKEKKLSFTKKEDVYKRSLQAAKKGRVLIFHWRGGYLTKEVLKELLELIRKAGDEKDKTAMVSINWPQAIIRVQYTDMQVQESVTIEEANEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZN9</accession>
    <name>A0A174GZN9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF2442)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060677.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66478">
        <property type="protein sequence ID" value="CUO66478"/>
        <property type="gene ID" value="ERS852478_03503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018841">
        <property type="entry name" value="DUF2442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036782">
        <property type="entry name" value="NE0471-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10387">
        <property type="entry name" value="DUF2442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143880">
        <property type="entry name" value="SSF143880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO66478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="99" mass="11199" checksum="4F666E0D27F4D827" modified="2016-09-07" version="1">MFVLNGIVYANEKSENIQVVSVKPLDDMMMILTFSTGEQRLFDASILTGSAYKPLSDEDIFKNCKVVDGVVTWLDEEIDCAPEYMYVNSYEYPSLKPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H021</accession>
    <name>A0A174H021_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060680.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68382">
        <property type="protein sequence ID" value="CUO68382"/>
        <property type="gene ID" value="ERS852478_03571"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043743">
        <property type="entry name" value="DUF5688"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18941">
        <property type="entry name" value="DUF5688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO68382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="314" mass="36175" checksum="121DD01F014E140E" modified="2016-09-07" version="1">MRKEEIDELQREVQKNLGEKWEVKPMSVKKIGGDKEAIGCRFQGDEFMVVLYPNEYENLLRSGTSIEEIGTHLAQEAEQKRYGFPQMPKTPEEFRKELYIQVINADMNEELLKNVVHDTMGDVAAVARCKIASDEQGVTSFLVTKENMECFQMTQGEIMEQAYHNTAAQKYTLQNLNEIMRELMTSEGLDPEIVKELTHEETPLYVLTNSERVNGANAIVCPEVLQHVYEELGENYYIMPSSIHEVLLVKESTGLTPDEMKRMVHDVNVSEVRPEELLSFKVFRYDGRKLSVVNEEIQEISEAKEKIKHSKLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H0K5</accession>
    <name>A0A174H0K5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060673.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66589">
        <property type="protein sequence ID" value="CUO66589"/>
        <property type="gene ID" value="ERS852478_03507"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO66589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="315" mass="37407" checksum="88CB19D5645294E3" modified="2016-09-07" version="1">MVPLKYQKNENLEKKYYKLITQSRNERFIEEIDEKCQCYLKMPFKNLVCASPEELEQLHSNVKDRTDYGQMKDAFKHISSIKQNNYIVSILFQNMPKEAKLLIYEQVGQNVCLYCNRNFIEDLKIVKNRNGRKPVGTFELDHFYSKDEFPMFAVSFYNLIPVCGTCNRIKSNTVFNINPYLMYDKKDNISFEYNILGSNYMENEDELEIRIKSSSKEALEDAQNLRLEEIYNRHKDIVQEIIKKMKYYNSEYIECLFKDTGALFQSKDELYRLLYGGYANPDEFGKRPLSKFIKDIYQNTKEVLDGFDIFSDIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H3C7</accession>
    <name>A0A174H3C7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201418.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67325">
        <property type="protein sequence ID" value="CUO67325"/>
        <property type="gene ID" value="ERS852478_03533"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008319">
        <property type="entry name" value="UCP031644"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031644">
        <property type="entry name" value="UCP031644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GyrI-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO67325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="210" mass="24750" checksum="7D2E9ACAD43DC202" modified="2016-09-07" version="1">MTFDYKKEYKEFYMPKGTPSIVRVPKMNYIAVRGSGNPNDADGEYKQSIGLLYGIAFTIKMSKKEDHQIDGYFDYVVPPLEGFWWQEGVSGIDYARKEEFKWISVIRLPDFVSREDFDWAVRKATEKKKQDFSKVEFFSYDEGLCVQCIHIGSYDDEPATVDEMHRFMEEQGYALDITDQRMHHEIYLSDARRVAPEKRKTVVRHPIRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HCD5</accession>
    <name>A0A174HCD5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bifunctional folate synthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Dihydroneopterin aldolase</fullName>
                <shortName evidence="10">DHNA</shortName>
                <ecNumber evidence="10">4.1.2.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">7,8-dihydroneopterin aldolase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
                <ecNumber evidence="10">2.7.6.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
                <shortName evidence="10">PPPK</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase</fullName>
                <shortName evidence="10">HPPK</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="primary">sulD</name>
        <name evidence="12" type="ORF">ERS852478_03647</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381442.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70800">
        <property type="protein sequence ID" value="CUO70800"/>
        <property type="gene ID" value="ERS852478_03647"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00154"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00534">
        <property type="entry name" value="DHNA_DHNTPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00525">
        <property type="entry name" value="folB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="11">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO70800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="283" mass="32294" checksum="8E6A9980589630E7" modified="2016-09-07" version="1">MDETRLDKIEIKELEVFANHGVYPEENVLGQKFVISATLFTRTRLAGLTDELSASINYGEVSHMITDFTRKHTYKLLESLAENLAEMLLCSLSGLEKITLKIEKPWAPVALPLKTVSVEITRKWHTAYIAFGSNMGDKKMYIDNGIRGLAETKGCRIEAISDYLITEPYGVTDQDEFLNGVLKMRTLLTPGELLVRLHQLEQAANRERIIHWGPRTLDLDILFYDQEIIDMPDLHIPHIDLHNRDFVLVPMNQIAPYLRHPVLNQTISQLLDSLLNKSENTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HCF6</accession>
    <name>A0A174HCF6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70858">
        <property type="protein sequence ID" value="CUO70858"/>
        <property type="gene ID" value="ERS852478_03649"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="40"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO70858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="165" mass="19548" checksum="FB55ACB00BD384EC" modified="2016-09-07" version="1">MNNNFSDMDRVNQIWRHPVYQEHYKKIQELESERIFCRHTPEHFLDVARLMYIYALEEHLELSKELIYAAALLHDIGRAQQYQYNIPHDIAGVEIAREILTDLHFTEQEKELILSSIGHHRKGDSRSTLAALLYKADKQSRNCFLCSAASECYWSDDKKNMKIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HFI0</accession>
    <name>A0A174HFI0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative dipeptidase SA1572</fullName>
            <ecNumber evidence="4">3.4.13.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_03748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.4.13.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000046">
        <property type="protein sequence ID" value="CUO73643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379883.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000071.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73643">
        <property type="protein sequence ID" value="CUO73643"/>
        <property type="gene ID" value="ERS852478_03748"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010964">
        <property type="entry name" value="M20A_pepV-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01887">
        <property type="entry name" value="dipeptidaselike"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO73643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="452" mass="49188" checksum="5677BBE752249FEC" modified="2016-09-07" version="1">MDIKEQIHGLTEEMLTNLGRLVAIDSQLGTPAEGKPFGEGPAKALEEGLKIAQELGFKTVNLDNYCGYAEMGEGDEIVGIAGHLDIVPVGGDWSYDPFKLTREGDYVYGRGTTDDKGPVLEALYAMKLLRDSGVKLNKRVRLIMGCNEETGSKCMEHYNEVAEELSCGFTPDASFPCIHGEKGLLRMMAYSKNTKIISADGGFVFNAVCDSSTIVVPAEEGLKERLEAVLAETKLQEYKVTEGNGQISIYAKGVPAHASTPTLGVNAIGVTFECLEKAGFKDDFVEFYNTHIGTSCDGEGIGLKFADEYGELTLCNGMIKTENDVISCTIDIRVPVTLKADEVRRMCESRLEDENGRIEILGIGDALFFPRESPLVNALYKAYTDVTGDTENKPMVIGGGTYAKSLKNIIAFGPEKPGIDYRIHSADEFILVSGMEEAVLVYMEAIKNLLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HP49</accession>
    <name>A0A174HP49_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="2">4.4.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gloA</name>
        <name evidence="2" type="ORF">ERS852478_03791</name>
        <name evidence="3" type="ORF">GT712_03965</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.4.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000049">
        <property type="protein sequence ID" value="CUO74918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201527.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74918">
        <property type="protein sequence ID" value="CUO74918"/>
        <property type="gene ID" value="ERS852478_03791"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO74918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS88268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="118" mass="14113" checksum="0CE57313620C068D" modified="2016-09-07" version="1">MKFKMIHENYNVSDLDRSIKFYNEALDLHEVRRKTTDDFIIVYLSNDVSDFELELTWLKDHPQPYNLGECEFHLAFKAEDYEAAYKKHKEMGCICFENEAMGIYFIVDPDGYWLEILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K741</accession>
    <name>A0A174K741_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="9">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="9">DXP synthase</shortName>
            <shortName evidence="9">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dxs_1</name>
        <name evidence="9" type="synonym">dxs</name>
        <name evidence="11" type="synonym">dxs_2</name>
        <name evidence="11" type="ORF">ERS852478_01166</name>
        <name evidence="12" type="ORF">ERS852523_00487</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">2789STDY5834863</strain>
            <strain evidence="12 14">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="9">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP07973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055149400.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2136"/>
    <dbReference type="EnsemblBacteria" id="CUN82441">
        <property type="protein sequence ID" value="CUN82441"/>
        <property type="gene ID" value="ERS852478_01166"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07973">
        <property type="protein sequence ID" value="CUP07973"/>
        <property type="gene ID" value="ERS852523_00487"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="10">
        <location>
            <begin position="314"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="9">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="9">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN82441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP07973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="623" mass="68298" checksum="AB265C7ED4F3CDC1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MAZ6</accession>
    <name>A0A174MAZ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 14" type="primary">rplV</name>
        <name evidence="17" type="ORF">BWLFYP14_00260</name>
        <name evidence="13" type="ORF">ERS852478_01662</name>
        <name evidence="14" type="ORF">ERS852523_01290</name>
        <name evidence="16" type="ORF">GT712_08965</name>
        <name evidence="15" type="ORF">GT728_04715</name>
    </gene>
    <organism evidence="14 19">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 18">2789STDY5834863</strain>
            <strain evidence="14 19">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="15 21 22" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 22">BIOML-A1</strain>
            <strain evidence="16 21">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="17 20" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707257.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2979"/>
    <dbReference type="EnsemblBacteria" id="CUO02757">
        <property type="protein sequence ID" value="CUO02757"/>
        <property type="gene ID" value="ERS852478_01662"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33523">
        <property type="protein sequence ID" value="CUP33523"/>
        <property type="gene ID" value="ERS852523_01290"/>
    </dbReference>
    <dbReference type="GeneID" id="66496125"/>
    <dbReference type="eggNOG" id="COG0091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO02757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUP33523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL32521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZS89198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VUX67419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="129" mass="14510" checksum="D201B9468706EBA9" modified="2016-09-07" version="1">MAKGHRSQIKRARNESNRETRPSAKLSYARISVQKACYVLDVIRGKDVQTALGILTYNPRYASSVIKKLLESAIANAENNNGMNADNLYVAACYADKGPTMKRIQPRAQGRAYRIEKRTSHITIVLDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174N7J5</accession>
    <name>A0A174N7J5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00375</name>
        <name evidence="2" type="ORF">ERS852523_01564</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000013">
        <property type="protein sequence ID" value="CUP42065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52688">
        <property type="protein sequence ID" value="CUN52688"/>
        <property type="gene ID" value="ERS852478_00375"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP42065">
        <property type="protein sequence ID" value="CUP42065"/>
        <property type="gene ID" value="ERS852523_01564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN52688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP42065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="64" mass="7658" checksum="23D3B0A35469ACAC" modified="2016-09-07" version="1">MDNVRRKHLSFRKTRIKMLVSDQVAETCDACDRTEDLRVLHFSIYADFYSDRKSIKTDKTIFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NCF8</accession>
    <name>A0A174NCF8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine-rich small domain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Cysteine-rich small domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_01573</name>
        <name evidence="2" type="ORF">ERS852478_02327</name>
        <name evidence="3" type="ORF">ERS852523_01614</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO27047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP43745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705592.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000126_gene3816"/>
    <dbReference type="EnsemblBacteria" id="CUO27047">
        <property type="protein sequence ID" value="CUO27047"/>
        <property type="gene ID" value="ERS852478_02327"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP43745">
        <property type="protein sequence ID" value="CUP43745"/>
        <property type="gene ID" value="ERS852523_01614"/>
    </dbReference>
    <dbReference type="GeneID" id="66494444"/>
    <dbReference type="eggNOG" id="COG2158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007212">
        <property type="entry name" value="Zf-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04071">
        <property type="entry name" value="zf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO27047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP43745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="98" mass="11599" checksum="EDB1F3F9D4F1F58D" modified="2016-09-07" version="1">MEKPYWEGKEYSYFSHKKCEFFPCHKNADPDDFNCLFCYCPLYALGEKCGGNFRYTEKGIKDCTNCMLPHKRKNYGYVTGKYQELADMMKRAKESISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174PWA3</accession>
    <name>A0A174PWA3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">V-type ATP synthase subunit K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_01715</name>
        <name evidence="8" type="ORF">ERS852523_02331</name>
        <name evidence="10" type="ORF">GT712_12275</name>
        <name evidence="9" type="ORF">GT728_09915</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
            <strain evidence="8 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BIOML-A1</strain>
            <strain evidence="10 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000024">
        <property type="protein sequence ID" value="CUP65302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000020">
        <property type="protein sequence ID" value="MZL33504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705339.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000018_gene60"/>
    <dbReference type="EnsemblBacteria" id="CUO05309">
        <property type="protein sequence ID" value="CUO05309"/>
        <property type="gene ID" value="ERS852478_01715"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP65302">
        <property type="protein sequence ID" value="CUP65302"/>
        <property type="gene ID" value="ERS852523_02331"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
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    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
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    </dbReference>
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        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="6">
        <location>
            <begin position="80"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO05309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP65302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS89829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="143" mass="14417" checksum="9388D6D590D4FA47" modified="2016-09-07" version="1">MTTIAQIILAIALVLSIILPFGYYLIGEKNRGRYKTALGVNAFFFFGTMLIAIAVMFTGASSVQAAAGSEGTLATGMGYIAAALVTGLSCIGGGIAVASAASAALGAISEDQSILGKSLIFVGLAEGVALYGLIISFMILGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174Q3X1</accession>
    <name>A0A174Q3X1_9FIRM</name>
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        <submittedName>
            <fullName evidence="4">Methionine synthase</fullName>
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        </submittedName>
    </protein>
    <gene>
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        <name evidence="3" type="synonym">metH_1</name>
        <name evidence="3" type="ORF">ERS852478_01785</name>
        <name evidence="4" type="ORF">ERS852523_02384</name>
        <name evidence="5" type="ORF">GT728_05645</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.13" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUP66541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZL32702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_WWVQ01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000164_gene904"/>
    <dbReference type="EnsemblBacteria" id="CUO07490">
        <property type="protein sequence ID" value="CUO07490"/>
        <property type="gene ID" value="ERS852478_01785"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP66541">
        <property type="protein sequence ID" value="CUP66541"/>
        <property type="gene ID" value="ERS852523_02384"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
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        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
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        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B12_BINDING_NTER"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="B12-binding N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
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            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO07490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP66541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL32702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="211" mass="23069" checksum="6564ACBEB7ED332F" modified="2016-09-07" version="1">MTVLEQLRKTIEDGHPGETEKLVREALKQHIPAGRIVEEAMTPAMRTVGENYKSNGADIIKILAAARSVRKGFELLEEQDSQFGRRNIGTVILGTVEGDLHDVGKNLVAIMFRSAGFKVIDLGVDISEKQFLRAVKQNPDVSIVCISSLLSTSIPEMEQVVKSLKRSSSKHKFKIMVGGGAVTEQLAKNMGADAYTENCIEAVEVAKTFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QA30</accession>
    <name>A0A174QA30_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted integral membrane protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">VanZ family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">VanZ like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BWLFYP14_01483</name>
        <name evidence="3" type="ORF">ERS852478_02230</name>
        <name evidence="4" type="ORF">ERS852523_02425</name>
        <name evidence="6" type="ORF">GT712_11650</name>
        <name evidence="5" type="ORF">GT728_09345</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000025">
        <property type="protein sequence ID" value="CUP67828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000018">
        <property type="protein sequence ID" value="MZL33397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000022">
        <property type="protein sequence ID" value="MZS89709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705487.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000042_gene3026"/>
    <dbReference type="EnsemblBacteria" id="CUO24112">
        <property type="protein sequence ID" value="CUO24112"/>
        <property type="gene ID" value="ERS852478_02230"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP67828">
        <property type="protein sequence ID" value="CUP67828"/>
        <property type="gene ID" value="ERS852523_02425"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="17"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO24112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP67828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL33397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS89709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX64630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="157" mass="18201" checksum="ED69622D5494AA10" modified="2016-09-07" version="1">MKKETKHIIRTLGTILFILYVLALIYFLFFSEEYGRAAMEERQYRYNLIPFVEIRRFWVYRKQLGLMAVVTNLFGNVIGFLPFGFILPVILDKMRSGWLIVLAGFGLSVTVEVIQLITKVGCFDVDDMILNTAGAALGYLLFFICDHLRRKIYGKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QDB3</accession>
    <name>A0A174QDB3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 3">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hpt</name>
        <name evidence="9" type="ORF">BWLFYP14_00602</name>
        <name evidence="5" type="ORF">ERS852478_02702</name>
        <name evidence="6" type="ORF">ERS852523_02556</name>
        <name evidence="8" type="ORF">GT712_18415</name>
        <name evidence="7" type="ORF">GT728_09425</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 3"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000027">
        <property type="protein sequence ID" value="CUP71292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000019">
        <property type="protein sequence ID" value="MZL33411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000060">
        <property type="protein sequence ID" value="MZS90966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993437.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000099_gene784"/>
    <dbReference type="EnsemblBacteria" id="CUO40313">
        <property type="protein sequence ID" value="CUO40313"/>
        <property type="gene ID" value="ERS852478_02702"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP71292">
        <property type="protein sequence ID" value="CUP71292"/>
        <property type="gene ID" value="ERS852523_02556"/>
    </dbReference>
    <dbReference type="GeneID" id="66495158"/>
    <dbReference type="eggNOG" id="COG0634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="14"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO40313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP71292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS90966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX62824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="176" mass="19852" checksum="C468CCD930E24654" modified="2016-09-07" version="1">MSEKIKVLLSEEEVDSRIKQIAAKVSKDYAGKEIHLICVLKGGVFFTCELAKRITVPVSLDFMSVSSYGDDTKSSGVVKIVKDLDQPLEGKDVLIVEDIIDSGRTLSYLIEILKQRNPNSIRLCTLLDKPERRVRDVRVDYCCFNIPDEFVVGYGLDYAQKYRNLPFIGVVELGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QQC9</accession>
    <name>A0A174QQC9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative protease YhbU</fullName>
            <ecNumber evidence="3 6">3.4.-.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">U32 family peptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Uncharacterized protease yhbU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhbU_2</name>
        <name evidence="2" type="synonym">yhbU_1</name>
        <name evidence="6" type="ORF">BWLFYP14_00359</name>
        <name evidence="2" type="ORF">ERS852478_01079</name>
        <name evidence="3" type="ORF">ERS852523_02694</name>
        <name evidence="5" type="ORF">GT712_13550</name>
        <name evidence="4" type="ORF">GT728_14220</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="3 6"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000030">
        <property type="protein sequence ID" value="CUP75422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000037">
        <property type="protein sequence ID" value="MZL34322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000028">
        <property type="protein sequence ID" value="MZS90068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994100.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000035_gene3829"/>
    <dbReference type="EnsemblBacteria" id="CUN79383">
        <property type="protein sequence ID" value="CUN79383"/>
        <property type="gene ID" value="ERS852478_01079"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP75422">
        <property type="protein sequence ID" value="CUP75422"/>
        <property type="gene ID" value="ERS852523_02694"/>
    </dbReference>
    <dbReference type="GeneID" id="66496232"/>
    <dbReference type="eggNOG" id="COG0826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032525">
        <property type="entry name" value="Peptidase_U32_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16325">
        <property type="entry name" value="Peptidase_U32_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01276">
        <property type="entry name" value="PEPTIDASE_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_U32_C" evidence="1">
        <location>
            <begin position="324"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN79383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP75422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX67514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="407" mass="46684" checksum="FE71EB01AA09FF7F" modified="2016-09-07" version="1">MRKIELLVPASSLEVLKIAVIFGADAVYIGGEAFGLRAKAKNFSHEDMKEGIAFAHEHGVKVYVTVNILAHNYDLPGVREYLTELKELKPDALIIADPGIYMYAKEICPEIERHISTQANNTNYETYRFWYNLGAKRVVTARELSLAEIKEIREHIPEDMEIETFIHGAMCISYSGRCLLSNYLAGRDANQGACTHPCRWKYSIVEEKRPGEYMPVFENERGTYIFNSKDLCMIEHMDDIINSGIDSLKIEGRMKTALYVATVARTYRKAIDDYMESPEKYQANMPWYQEQISNCTYRQFTTGFFYGKPDENTQIYDNNTYQKEYTYLGFAEAVDERGYAQITQRNKFSVGETIEIMKPDGQNVAVTVKGIYDEEGNSMESAPHAQQKLFIDLGTEIQVYDLLRRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QWX6</accession>
    <name>A0A174QWX6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PadR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator PadR-like family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, Acidobacterial, PadR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_02056</name>
        <name evidence="2" type="ORF">ERS852478_00442</name>
        <name evidence="3" type="ORF">ERS852523_02731</name>
        <name evidence="5" type="ORF">GT712_06545</name>
        <name evidence="4" type="ORF">GT728_14830</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000031">
        <property type="protein sequence ID" value="CUP76441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000040">
        <property type="protein sequence ID" value="MZL34439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000009">
        <property type="protein sequence ID" value="MZS88738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993548.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000051_gene801"/>
    <dbReference type="EnsemblBacteria" id="CUN54665">
        <property type="protein sequence ID" value="CUN54665"/>
        <property type="gene ID" value="ERS852478_00442"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP76441">
        <property type="protein sequence ID" value="CUP76441"/>
        <property type="gene ID" value="ERS852523_02731"/>
    </dbReference>
    <dbReference type="GeneID" id="66496073"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN54665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP76441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="106" mass="11947" checksum="958D5197A45276C2" modified="2016-09-07" version="1">MVFNTGAALLDAVVLAVVSKEKEGTYGYKITQDVRGVLDVSESTLYPVLRRLQKDDCLEVYDMAYAGRNRRYYKLTDRGAAQLEFYKAEWKIYASKISGMFEGGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174S4S6</accession>
    <name>A0A174S4S6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">adaA_5</name>
        <name evidence="7" type="synonym">adaA_4</name>
        <name evidence="7" type="ORF">ERS852478_03000</name>
        <name evidence="8" type="ORF">ERS852523_03204</name>
        <name evidence="9" type="ORF">GT728_10065</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
            <strain evidence="8 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO49851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000042">
        <property type="protein sequence ID" value="CUP90140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000021">
        <property type="protein sequence ID" value="MZL33533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577751.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000010_gene2782"/>
    <dbReference type="EnsemblBacteria" id="CUO49851">
        <property type="protein sequence ID" value="CUO49851"/>
        <property type="gene ID" value="ERS852478_03000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP90140">
        <property type="protein sequence ID" value="CUP90140"/>
        <property type="gene ID" value="ERS852523_03204"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="429"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO49851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP90140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="527" mass="60983" checksum="7C7B02AB99CEE3DF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174S767</accession>
    <name>A0A174S767_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation:dicarboxylase symporter family transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Sodium:dicarboxylate symporter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_02443</name>
        <name evidence="9" type="ORF">ERS852523_03281</name>
        <name evidence="10" type="ORF">GT712_04145</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
            <strain evidence="9 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO31295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000044">
        <property type="protein sequence ID" value="CUP92201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381450.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000097.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31295">
        <property type="protein sequence ID" value="CUO31295"/>
        <property type="gene ID" value="ERS852478_02443"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP92201">
        <property type="protein sequence ID" value="CUP92201"/>
        <property type="gene ID" value="ERS852523_03281"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO31295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP92201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS88301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="403" mass="42964" checksum="67B0747F2C2D5382" modified="2016-09-07" version="1">MKKNFFLHSLPFRLLVGVAFGICIGLLLNIIDESAITTAVLNVVVTSKYILGQLISFSVPLIIIGFIAPSITRLGNNASRMLGVAVSIAYASSLGAALFSALSGYLLIPHLSFSSTASHLKALPDVVFELSIPQIMPVMSALVLAIMLGLASAWTKASLISSFLEEFQKIILAIVSRVIIPILPYFIGLTFCSLAYEGTITRQLPVFLQVIVIVLIGHFIWIALLYILAGIYSRENPLKVVKHYGPAYLTAIGTMSSAATLPVALQCAHRAKPLRKDLVDFGIPLFANIHLCGSVLTEVFFCMAISKILYGAVPAPGAMVLFCVLLGIFAIGAPGVPGGTVMASLGIITGILKFGDSATALMLTIFALQDSFGTACNVTGDGALTLILTGYARYHNIREQKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SVK6</accession>
    <name>A0A174SVK6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC-type sugar transport system, periplasmic component</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02807</name>
        <name evidence="4" type="ORF">ERS852523_03633</name>
        <name evidence="5" type="ORF">GT728_08495</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000058">
        <property type="protein sequence ID" value="CUQ01834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000016">
        <property type="protein sequence ID" value="MZL33233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058632.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43503">
        <property type="protein sequence ID" value="CUO43503"/>
        <property type="gene ID" value="ERS852478_02807"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ01834">
        <property type="protein sequence ID" value="CUQ01834"/>
        <property type="gene ID" value="ERS852523_03633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014252557" evidence="1">
        <location>
            <begin position="31"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="38"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO43503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUQ01834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL33233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="380" mass="40881" checksum="35F7FD3D9FC2AD34" modified="2016-09-07" version="1">MKKRMRKAVAIAATAAMVGSLPAGAVTAQAADDDITIGVSIWSSTDVLGSQSKKIIDKAADALGVNVMYVDQGHVSEQVTASVEQLCAAGCNGIVICNSADSEMTSAIQTCDANQVYLTQFYRIISEENSPEVYQTACNSQYYLGAVHEDEVTNGYTLVNLLLENGDRNIGLEAWTVGDATFQQRWTGYKQAVDEWNEANPDDQATITEPVYANTSSEEGAAAALSLYNSNPDMDALIVAGGGGDPLVGSIGALANEGLTGKIDVVSTDFLDDLGEQLESGGMFAESGGHFCDPLYAFLITYNAIKGNYVKDEGSFGYEIQFPYLYVSSSEDYENYKKYFVDDDPYTDEELVELAGYSFDDLNKAATSLSIEDVISRHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174TY65</accession>
    <name>A0A174TY65_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">ureF</name>
        <name evidence="4" type="ORF">ERS852478_03288</name>
        <name evidence="5" type="ORF">ERS852523_04093</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
            <strain evidence="5 7">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO59316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000080">
        <property type="protein sequence ID" value="CUQ13391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055153858.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000010_gene2766"/>
    <dbReference type="EnsemblBacteria" id="CUO59316">
        <property type="protein sequence ID" value="CUO59316"/>
        <property type="gene ID" value="ERS852478_03288"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ13391">
        <property type="protein sequence ID" value="CUQ13391"/>
        <property type="gene ID" value="ERS852523_04093"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0830">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009467">
        <property type="entry name" value="Ureas_acces_UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO59316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUQ13391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="230" mass="26203" checksum="F8D920EF4EDC7AC0" modified="2016-09-07" version="1">MSEKQFYLLQVNDALFPIGGYSHSQGLETYIQRGIVHDADTAREYITHKIKWNLAYTELLAARLAYEAAEKKDLQELLYLEELLEASRIPMEQREAARKMGSRFAKTIEKLGLSISETGIFREYLDARKGKAVNHCCIYGVFCAEMQISLEEALTHYLYAQTSAIVTNCVKTIPLSQTSGQQLLSGCYGEFDEILKDIMNRSEEDLCLSAPGFDIRGIQHEKLYSRLYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WPS5</accession>
    <name>A0A173WPS5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SPBc2 prophage-derived glycosyltransferase SunS</fullName>
            <ecNumber evidence="2">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sunS</name>
        <name evidence="2" type="ORF">ERS852478_00030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41559">
        <property type="protein sequence ID" value="CUN41559"/>
        <property type="gene ID" value="ERS852478_00030"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN41559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="351" mass="41760" checksum="CF111BBA63C25578" modified="2016-09-07" version="1">MIVKNEEKVLPRILKPMKEIVDKILICDTGSTDRTKEIIREFTAEVYDFPWKNDFSAARNFISEKVSTDYWMWLDADDMITQENLYRLKQLKETLSPNTDMVMMDYVTDFDEWNHAAFSCYRERILKTSRNFRWRGRVHESIIPTGNILYSPIQIEHRKIKPCSSFRNLHIYQQMIEEGEPLEPRDLFYYGRELFYHKQYEYAICVLKKFLKEPDGWIENRLDSCLVLSYCYQASGNDQHALEILFHSFMSDIPRAEICCEIGKIFFMKQNFSMAAHWYHQALLAPDNSQNGGFYIPDCHNFIPFLQLCVCLDKSGMHKEAFEFHRKARTLKPEHPSVIQNQIYFHEILGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WS22</accession>
    <name>A0A173WS22_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glpK_1</name>
        <name evidence="5 11" type="synonym">glpK</name>
        <name evidence="12" type="ORF">BWLFYP14_02554</name>
        <name evidence="9" type="ORF">ERS852478_00053</name>
        <name evidence="10" type="ORF">ERS852523_00714</name>
        <name evidence="11" type="ORF">GT712_07640</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">2789STDY5834863</strain>
            <strain evidence="10 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer and homodimer (in equilibrium).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP15484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577002.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1417"/>
    <dbReference type="EnsemblBacteria" id="CUN42303">
        <property type="protein sequence ID" value="CUN42303"/>
        <property type="gene ID" value="ERS852478_00053"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15484">
        <property type="protein sequence ID" value="CUP15484"/>
        <property type="gene ID" value="ERS852523_00714"/>
    </dbReference>
    <dbReference type="GeneID" id="66492879"/>
    <dbReference type="eggNOG" id="COG0554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="259"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="409"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN42303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP15484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS88943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX66182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="498" mass="54805" checksum="1F65A972311310DA" modified="2016-09-07" version="1">MGKYIMALDAGTTSNRCILFNEKGERLSVAQREFTQYFPKPGWVEHDADEIWASMLGVAVEAMTKIGADASKIAAIGITNQRETAIVWDKNTGVPVYHAIVWQCRRTSEYCDSLKARGLTEKFREKTGLVIDAYFSATKIKWILDNVEGAREKAQKGQLLFGTVETWLIWKLTKGRVHVTDYSNASRTMLFNINTLQWDQEILNELDIPKSMLPKPMPSSCIYGKADPAVLGGAIPIAGAAGDQQAALFGQTCFNAGEAKNTYGTGCFLLMNTGEKPVFSKNGLVTTIAWGLDGKVTYALEGSIFVAGAAIQWLRDELKVIDSSEDSEYMANKVSDTHGCYVVPAFTGLGAPHWDQYARGTIVGITRGVNKYHIIRATLESIAYQVNDVLNAMKADSGINLAALKVDGGASANNFLMQTQADIINAPVNRPCCVETTAMGAAYLAGLAVGYWSSKEEVRHNWSIDQKFYPSITEETREQKIKGWNKAVKYSYGWAKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WWJ2</accession>
    <name>A0A173WWJ2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTPase Obg</fullName>
            <ecNumber evidence="6">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">obg</name>
        <name evidence="13" type="ORF">BWLFYP14_02598</name>
        <name evidence="11" type="ORF">ERS852478_00100</name>
        <name evidence="12" type="ORF">ERS852523_01890</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">2789STDY5834863</strain>
            <strain evidence="12 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP52144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993902.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000020_gene126"/>
    <dbReference type="EnsemblBacteria" id="CUN43714">
        <property type="protein sequence ID" value="CUN43714"/>
        <property type="gene ID" value="ERS852478_00100"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP52144">
        <property type="protein sequence ID" value="CUP52144"/>
        <property type="gene ID" value="ERS852523_01890"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03595">
        <property type="entry name" value="Obg_CgtA_exten"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="10">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="8">
        <location>
            <begin position="159"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="9">
        <location>
            <begin position="351"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="211"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="281"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="314"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN43714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP52144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX66226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="431" mass="47374" checksum="62F43F3D9E8B13C4" modified="2016-09-07" version="1">MFADRAKIYIRSGKGGDGHVSFRRELYVPNGGPDGGDGGRGGDVIFEVDEGQNTLGDYRHRRKYKAEDGQEGGKKRCHGADGKDVVLKVPEGTVIMDAESGKVIADMSGENKRQIVLRGGRGGKGNQHYATATMQVPKYAQPGQPAQELEVLLELKVIADVGLVGFPNVGKSTFLSRVTNAQPKIANYHFTTLSPNLGVVDTENGGFVIADIPGLIEGASEGVGLGHEFLRHIERTRVIIHIVDAASTEGRDPIDDIYKINKELEAYNPEIAARPQVIAANKIDCIYTEDGEESPIDKLKAEFEPKGIQVYPISAVSGQGVRELLFHVKELLDSCPQEPVVFEQEFFPEDMLIGENLPYTVEQSPEDPTIFVVEGPKIEKMLGYTNLDSEKGFAFFQKFLKEGGILEELEKAGIQEGDTVRMYGFDFDYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WX21</accession>
    <name>A0A173WX21_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluD_1</name>
        <name evidence="5" type="ORF">ERS852478_00112</name>
        <name evidence="6" type="ORF">GT712_00905</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703141.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44031">
        <property type="protein sequence ID" value="CUN44031"/>
        <property type="gene ID" value="ERS852478_00112"/>
    </dbReference>
    <dbReference type="GeneID" id="66495913"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN44031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS87683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="304" mass="34243" checksum="5A52B66F87CBE69A" modified="2016-09-07" version="1">MEILNYQVSDGQSGIRIDRYLSEMNEELSRSYIQKLLKEQKITVNGSAVKANYKVQEGDEISVAVPDIKEPDILPEDIPLDILYEDDDVLIVNKPKGMVVHPSAGHTSGTLVNAIMFHCKDNLSGINGVLRPGIVHRIDKDTTGALLVCKNDNAHRNLAEQLKEHSIRRRYRAIVAGVLKEDEGTIEGPIGRHPIDRKKMAVNYKNGKDAVTHYKVLERFKNATYVECRLETGRTHQIRVHMTSIGHPLLGDEVYGSGKNPYHLQGQTLHAMILGFVHPSTGEYMEFTAPLPEYFVKLLEKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X0J1</accession>
    <name>A0A173X0J1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="7">GPR</shortName>
            <ecNumber evidence="7">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="7">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">proA</name>
        <name evidence="9" type="ORF">ERS852478_00161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052767.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45292">
        <property type="protein sequence ID" value="CUN45292"/>
        <property type="gene ID" value="ERS852478_00161"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="10"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="316"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN45292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="416" mass="45497" checksum="1183AB2EE4FAE264" modified="2016-09-07" version="1">MNEMLNRLGMNAKAAETEMRNLSTNKKNEVLLAVADKLVKDAQTLINANRLDVETGKRNHMPEGLIDRLLLTESRIEGMAEGLRQVAALDDPVGEVTGMKKRPNGLLIGQKRVPLGVIGIIYEARPNVTADAFALCFKTGNVVILKGGSDAIHSNEAIVNCIRETLNEQGVTEDAIQLISDTSRETAAEFMKMNQYVDVLIPRGGRGLIKAVVEQSTIPVIETGTGNCHIYVDETADLEMAADIIMNAKTQRVGVCNACESVLVHKDVKDALLPVLAKRLQEKHVEIRADEAAYALIPGAVHATEEDWGKEYLDYILSIKVVSSVEEAIAHINKYNTKHSEAIITNNYEHAQKFLDEVDAAAVYVNASTRFTDGFEFGFGAEIGISTQKLHARGPMGLLALTTTKYIIYGNGQVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X4W7</accession>
    <name>A0A173X4W7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Phosphate propanoyltransferase</fullName>
            <ecNumber evidence="4 7">2.3.1.222</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pduL_1</name>
        <name evidence="9" type="synonym">pduL</name>
        <name evidence="8" type="ORF">ERS852478_00215</name>
        <name evidence="9" type="ORF">GT728_05920</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>phosphate + propanoyl-CoA = CoA + propanoyl phosphate</text>
            <dbReference type="Rhea" id="RHEA:28046"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58933"/>
            <dbReference type="EC" id="2.3.1.222"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Polyol metabolism; 1,2-propanediol degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PduL family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.222" evidence="4 7"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059495.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46781">
        <property type="protein sequence ID" value="CUN46781"/>
        <property type="gene ID" value="ERS852478_00215"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4869">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00621"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051144">
        <property type="term" value="P:propanediol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008300">
        <property type="entry name" value="PTAC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39453">
        <property type="entry name" value="PTHR39453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06130">
        <property type="entry name" value="PTAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010130">
        <property type="entry name" value="PduL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
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    <sequence length="212" mass="23837" checksum="8051BC5BB8868631" modified="2016-09-07" version="1">MSIKIPIETSARHLHISQEDFEKLFGEGSKPHFIKELSQPGQYLCRERVTVKGPKGTFENMALLGPFRSDTQVEMSLTDTRKLGIPSVIRQSGDIEGTPGCILSGPCGDIEIPKGVIVAKRHIHMTPDEALALHIKDNDEVFVLTKSYGRALIYADVVVRVHRNYHLAMHVDTDEANAFNSDTEPYGVIVRFFDSNFNTDKWIEDELSGIRR</sequence>
</entry>
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        <name type="scientific">Blautia wexlerae</name>
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        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
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                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
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            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BIOML-A1</strain>
        </source>
    </reference>
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            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        <property type="gene ID" value="ERS852478_00179"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CUN45738.1"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="MZL32788.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="837" mass="94762" checksum="C2EFC2D36467D5FE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X7L5</accession>
    <name>A0A173X7L5_9FIRM</name>
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        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">ERS852478_00234</name>
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        <name type="scientific">Blautia wexlerae</name>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="540" mass="57635" checksum="66C2DF7A948304DD" modified="2016-09-07" version="1"> </sequence>
</entry>
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    <accession>A0A173X8X4</accession>
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        </submittedName>
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    <reference evidence="1 3" key="1">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
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                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
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            </authorList>
            <dbReference type="PubMed" id="31477907"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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            <dbReference type="EMBL" id="CUN46838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL32753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="133" mass="15049" checksum="E19CA2793ABCAC45" modified="2016-09-07" version="1">MTDSNLVGTSFAGTNTKDLKLQLYIESDDGTKIEGIGGENTKVKEIHLPVYKASEKQAEYEDGYVYVNSGNVYDFTLNELQNYESYLKTSAGYKGKVTLYAKISCKYIYYCTEKEAQSIAQINICQRQLFDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
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    <protein>
        <submittedName>
            <fullName evidence="5">Lipoprotein-releasing system ATP-binding protein LolD</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lolD_1</name>
        <name evidence="5" type="ORF">ERS852478_00245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN48680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006858253.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPB010000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN48680">
        <property type="protein sequence ID" value="CUN48680"/>
        <property type="gene ID" value="ERS852478_00245"/>
    </dbReference>
    <dbReference type="GeneID" id="61432482"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN48680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="223" mass="24166" checksum="E2CD956A2EC02549" modified="2016-09-07" version="1">MEVLQAKNLKKIYGSGNNAVHALDGVDLSVKKGEFVAIVGTSGSGKSTLLHMLGGLDRPTSGTVMVDGQDIFSLKEEALTIFRRRKIGFVFQAYNLVPVLNVYENIVLPIELDGGKVNKDFVQQIVQTLGLDDRLDALPNQLSGGQQQRVAIARALAAAPAIILADEPTGNLDSKTSQDVLSLLKVTSQKFAQTIVMITHNEEIAQMADRIIRIEDGRIVSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XD79</accession>
    <name>A0A173XD79_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stage 0 sporulation protein A homolog</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rcsC</name>
        <name evidence="13" type="ORF">ERS852478_00276</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199540.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49613">
        <property type="protein sequence ID" value="CUN49613"/>
        <property type="gene ID" value="ERS852478_00276"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="333"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="477"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="718"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="860"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="772"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN49613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="982" mass="111169" checksum="5F9ED2E65BDDA5CC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XDV7</accession>
    <name>A0A173XDV7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yycF_1</name>
        <name evidence="10" type="synonym">yycF_6</name>
        <name evidence="9" type="ORF">ERS852478_00258</name>
        <name evidence="10" type="ORF">ERS852523_04043</name>
        <name evidence="11" type="ORF">GT712_17770</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
            <strain evidence="10 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000077">
        <property type="protein sequence ID" value="CUQ12195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000054">
        <property type="protein sequence ID" value="MZS90849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706580.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000119.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49077">
        <property type="protein sequence ID" value="CUN49077"/>
        <property type="gene ID" value="ERS852478_00258"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ12195">
        <property type="protein sequence ID" value="CUQ12195"/>
        <property type="gene ID" value="ERS852523_04043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN49077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUQ12195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS90849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="229" mass="26162" checksum="A55D748FC0B569CE" modified="2016-09-07" version="1">MPGILVVEDDENLNRGITFSLKKSGYEVFSAESVKKAKRIASDNNVDVTICDVNLPDGNGLEFVRWMRCNYNTYIICLTALDQEIDQVMGYEAGADDYITKPFSLSVLLLKIEAHFRRRQEKTEAGKMISGDIVFIAGEMKVLIKSREISLTKTELKMLTFFLQNPKQILSKTQILENVFDLEGDFVDENTIAVNIRRLREKIEDNPAAPVYIKNIRGLGYIWNQEVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XHU8</accession>
    <name>A0A173XHU8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-rhamnose operon regulatory protein rhaS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rhaS</name>
        <name evidence="4" type="ORF">ERS852478_00308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199561.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50586">
        <property type="protein sequence ID" value="CUN50586"/>
        <property type="gene ID" value="ERS852478_00308"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="221"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN50586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="327" mass="38243" checksum="495DDA999A4B2AAF" modified="2016-09-07" version="1">MQQELLDHLKKITEEEQKILDGRAEVDKEIYTSGRDFIVDSRKMLDEGKLITVRTHTRFVHFPAHRHNFIEVLYVCEGSVTNIIDGKKVVVGKGELLFLNQYTKHELLPAGESDIAINFMILPEFFDVTYSMAGRNNVLADFLVNILRQDEEKGEYLYFRVAEVLQIQNLLENMIYSLVTGKGENNRINQTTMGLIFLYLVDSVQYVEMRVPNQYENMISMTTLDYIEQKYKTATLTELCETLHLPMHVLSKMIKKTTGFNFKELLQRKRLNKSVELMCDTDLAISDIIAAVGYENNSYFHRVFKERYHMTPRAFREENRQQAQVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XIP3</accession>
    <name>A0A173XIP3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anaerobic benzoate catabolism transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51140">
        <property type="protein sequence ID" value="CUN51140"/>
        <property type="gene ID" value="ERS852478_00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN51140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="164" mass="18609" checksum="EC28F828D8036585" modified="2016-09-07" version="1">MSLDQVSEQTGVSKSMLAQIERGTANPSLGVLGKITSGLRIEFQELIQPPRVDCCLVTPAELVPTKEIAGQYRVWTCLPYEDTRLVEVYRIEVEPGGVYISGSHGEKTREYLAVMEGVLTLECHGEKYEIHRDQVFKFETDQEHVYRNTGKEKACCTCFFLDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XJC9</accession>
    <name>A0A173XJC9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51007">
        <property type="protein sequence ID" value="CUN51007"/>
        <property type="gene ID" value="ERS852478_00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN51007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="171" mass="18856" checksum="8A3D0972E5E01C6F" modified="2016-09-07" version="1">MNTTTTTTAAAKRSSTLYMVELAMMIAIILLMSFTPLGYLRTPGLSITLLTIPVAVGAIILGPKGGAVCGFTFGATSFYMAVCHRKFCFRSRTFQYQPGRATFIVCIVARVLEGWITGLIFAALHKSPAKKFSYYIASLACPLLNTFFFMGSLCLFFYNTDYFKVLFPPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XMX9</accession>
    <name>A0A173XMX9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Nickel import ATP-binding protein NikO</fullName>
            <ecNumber evidence="8">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nikO</name>
        <name evidence="8" type="ORF">ERS852478_00346</name>
        <name evidence="9" type="ORF">GT728_06590</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000011">
        <property type="protein sequence ID" value="MZL32877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199637.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51758">
        <property type="protein sequence ID" value="CUN51758"/>
        <property type="gene ID" value="ERS852478_00346"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN51758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL32877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="223" mass="25305" checksum="4FD6F95D68E66A5B" modified="2016-09-07" version="1">MIRLENVCFAYEKEIALRYVDLHINRGDSIVIQGPNGCGKSTLIKLLNGIIFPSEGKYFYQGHEINEKALKNSQFAKWFHQQMGYVFQNADAQLFCGSVEEEIAFGPVQMGLSEAEIKKRTEDCLHLFGLEKLRDRPPYHLSGGEKRKVSLACILSLNPEVLILDEPLAGLDEKTQDMLVDFLQSFHKAGKTLITITHNRQLAETIGTRFACMNEEHELKMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XRJ7</accession>
    <name>A0A173XRJ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199594.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53048">
        <property type="protein sequence ID" value="CUN53048"/>
        <property type="gene ID" value="ERS852478_00387"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN53048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="195" mass="22137" checksum="CC19A717677401E1" modified="2016-09-07" version="1">MAKRIITISREFGSGGRFIGEEVAKKLGIAYYDKNIIGQIAEKSGLSPEYIQENAELSPKKGLFAYAFSGRDITGKSVEDMVYEAQTNIILGLAEKEPCVIIGRNADYILKDRDDVLNVFIHGDMPEKIKRITGLYNVEEKEAVKMMADTDKRRRTNYNFYTDQNWGKASNYTLCLNSSQLGYDRCEMIIMECVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XZU3</accession>
    <name>A0A173XZU3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">C_GCAxxG_C_C family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199674.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57169">
        <property type="protein sequence ID" value="CUN57169"/>
        <property type="gene ID" value="ERS852478_00492"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032ZHX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010181">
        <property type="entry name" value="CGCAxxGCC_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09719">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01909">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN57169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="143" mass="15983" checksum="E5E392EAD7C808CD" modified="2016-09-07" version="1">MDLYERIMELGSMGYHCSQIIMIMTLETIGEENPQLVKAMGGLGGGIGYCGDTCGCLTGSACAIGYFLGNLAPEEKEDAQMKPAVQELYQWFRQKTEEEFGAFYCKDITHLDWGIIMEKCPGLIADTYTKVMEILTEREVLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y028</accession>
    <name>A0A173Y028_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carboxylate/amino acid/amine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199641.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56048">
        <property type="protein sequence ID" value="CUN56048"/>
        <property type="gene ID" value="ERS852478_00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="14"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="169"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN56048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="315" mass="33441" checksum="F6F2344D6A3CDD37" modified="2016-09-07" version="1">MSQKQNTLTRTGIVALLACVCCILWGSAIPVIKTGYSLMNVDSADTASQIVFAGIRFTLAGILVLIFASVREKKIIIPDREILKYAVPVCLAQTVGQYFFFYIGVAHTSGVKGAIITGLGNFIAILLSCLVFRKERMTGRKIAGCVLGFAGVVVINLMGNSLDMGFKLTGEGFILIAQLSYGISTVLINLFSRKVSPVVLSGTQFTMGGIVLTLIGIGMGGHLGNVTVGGVAIIFYLAMVSAVAYTLWSVLLAWNDVSKVAIFGFVNPLCSVILSALILGEVKQAFNIGSLVALILVCAGIYIVNAKVKESKREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y6R4</accession>
    <name>A0A173Y6R4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58665">
        <property type="protein sequence ID" value="CUN58665"/>
        <property type="gene ID" value="ERS852478_00540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN58665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="87" mass="9896" checksum="9D42913BCD69F9C3" modified="2016-09-07" version="1">MLHIVKIPNNEGDINNMRKFILGLSFLGFGDIGFLIVFTYTLFHQSIINGSEGWLINLIANDTLIPVIFFSLWIITGIIICIRSLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y7C4</accession>
    <name>A0A173Y7C4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60071">
        <property type="protein sequence ID" value="CUN60071"/>
        <property type="gene ID" value="ERS852478_00584"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50306D0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN60071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="205" mass="24275" checksum="FCC000AF60123989" modified="2016-09-07" version="1">MKDERKKLKLIILQCIAVITANFITIWYFEELFFRGFWYVIFASFILTFIYIIRSFCCLRKIRVFWFAAIPVFLFGIYLAFLFNDGIKKLNFQVYKEKRTEIVQMVQNNQIKIRKDMELIELPEDYKKCSSGGEAVVRKNNGSYTVGFWYTQGFLDSGFSLFAYSNDDSRTDVIQMVKEYGGIEYEINLSEKEKGWYYVTAKVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y8L4</accession>
    <name>A0A173Y8L4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199711.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59496">
        <property type="protein sequence ID" value="CUN59496"/>
        <property type="gene ID" value="ERS852478_00567"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50332GY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN59496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="106" mass="11980" checksum="93E0459553326EB5" modified="2016-09-07" version="1">MYDTKTRIALVKKRMHEYHRRQERRAVCRLSVLCTLLFLSLVGAMGIMQSQPINVTGMYGTILLHEDAGGYVLVAVISFNVAVVITALCIKFRKRGQKSQDAEDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YBB9</accession>
    <name>A0A173YBB9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tagG_2</name>
        <name evidence="9" type="ORF">BWLFYP14_03233</name>
        <name evidence="8" type="ORF">ERS852478_00623</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX66956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61432">
        <property type="protein sequence ID" value="CUN61432"/>
        <property type="gene ID" value="ERS852478_00623"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="21"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN61432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="271" mass="31538" checksum="40D50D5EEEF0DBE8" modified="2016-09-07" version="1">MNTIFSLPMDIYKNRRLVAKLAKNDFKTRYAGSYLGIVWAFIQPVITILVYWFVFSVGFRSGTGDLGVPFVLYLVAGIVPWFFFQDALIGGTNSLLEYNYLVKKVVFNISVLPVVKIISAMFVHAFFVLFTIILYAAYGKFPDFYYLQIIYYSVCVFILVLGLSYATSAIVIFFRDLTQIINIVLQVGVWLTPIMWIVEASPLMGHPVIMKILKLNPMYYIVSGYRDTFLMKTWFWEHAGWTVYFWIFTILCFLFGSWVFKRLRIHFADVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YBS7</accession>
    <name>A0A173YBS7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor 4</fullName>
            <shortName evidence="6">EF-4</shortName>
            <ecNumber evidence="6">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">lepA</name>
        <name evidence="8" type="ORF">ERS852478_00601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199720.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60667">
        <property type="protein sequence ID" value="CUN60667"/>
        <property type="gene ID" value="ERS852478_00601"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="5"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN60667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="602" mass="67508" checksum="B0838FF293365905" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YLX9</accession>
    <name>A0A173YLX9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">sn-glycerol-3-phosphate transport system permease protein ugpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ugpA_2</name>
        <name evidence="7" type="ORF">ERS852478_00671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199751.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64055">
        <property type="protein sequence ID" value="CUN64055"/>
        <property type="gene ID" value="ERS852478_00671"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN64055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="297" mass="34009" checksum="1F182FDFFF9A59E0" modified="2016-09-07" version="1">MANPKKGTSQARNEFIWGWAFILPTMLGLIILNIYPIFKTIYESFFKTGDFGKGNIFIGFDNYVKLFHDAEVWQALLNTFKYAIVEVPFSIAIALVLAVLLNRKMKGRAVYRTIFFLPMVAAPAAIAMVWRWLFNSEFGLLNHIFHTKINWISDPKIAVYAIAVIGVWSIIGYNMVLFLSGLQEIPRDYYEAASIDGATGVKQFFHITIPLLSPTIFFVMVTRVIGAMQVFDLIFMVMDRNNPALYKTQSLVYLFYQNSFVQNNKGYGSTIVVLLLVVIMIMTVFQNIAQKKWVHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YR67</accession>
    <name>A0A173YR67_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mrkE</name>
        <name evidence="9" type="synonym">mrkE_1</name>
        <name evidence="8" type="ORF">ERS852478_00718</name>
        <name evidence="9" type="ORF">ERS852523_00626</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
            <strain evidence="9 11">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP12418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578142.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000016_gene3663"/>
    <dbReference type="EnsemblBacteria" id="CUN65565">
        <property type="protein sequence ID" value="CUN65565"/>
        <property type="gene ID" value="ERS852478_00718"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12418">
        <property type="protein sequence ID" value="CUP12418"/>
        <property type="gene ID" value="ERS852523_00626"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="131"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN65565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP12418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="234" mass="27300" checksum="1CC41D069599265E" modified="2016-09-07" version="1">MIQIAIVEDEEIYVKQLTEYIRKYQTERGRSIKVTVFGDGEDITENYNGGFDIILMDIQMRFMDGMTAAEKIRQMDQKVIIMFITNMIQYAVRGYEVDAMDYVVKPVEYFSFSQKLDKAVGRMRSEVKEFLTIPIGEGVVKIDIADIYFIEGQRHNVIYHTSRGDYCSRITMKELEEKLAVHNFFRCAKGYLVNMNHVEGFVGSDCVIHNVHIPVSRTRKKEFMNLLLQNLNME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YU17</accession>
    <name>A0A173YU17_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartate--ammonia ligase</fullName>
            <ecNumber evidence="3">6.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Asparagine synthetase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">asnA</name>
        <name evidence="7" type="ORF">BWLFYP14_01778</name>
        <name evidence="5" type="ORF">ERS852478_00743</name>
        <name evidence="6" type="ORF">GT728_03885</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-aspartate + NH4(+) = AMP + diphosphate + H(+) + L-asparagine</text>
            <dbReference type="Rhea" id="RHEA:11372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058132.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66535">
        <property type="protein sequence ID" value="CUN66535"/>
        <property type="gene ID" value="ERS852478_00743"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00134">
        <property type="reaction ID" value="UER00194"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004071">
        <property type="term" value="F:aspartate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070981">
        <property type="term" value="P:L-asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00645">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00555">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004618">
        <property type="entry name" value="AsnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30073">
        <property type="entry name" value="PTHR30073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03590">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001555">
        <property type="entry name" value="Asp_ammon_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00669">
        <property type="entry name" value="asnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="4">
        <location>
            <begin position="111"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN66535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL32357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX64982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="335" mass="38362" checksum="A19EAB893C10BCA3" modified="2016-09-07" version="1">MEQIKIPDGYQSSLNLHDTQIAIKTVKDFFQQTLAQKLNLLRVSAPVFVNPSSGLNDNLNGVERPVSFDIKGQPENAEIVHSLAKWKRYALQKYGFAHGEGLYTDMIAIRRDEDLDNIHSVYVDQWDWEKIISKEERNMDTLVSTVRAIYSVLRKTEKYMAVQYDYIEEILPREIAFVSTQELVDMYPDLTPKEREYKIVKEKGAVFLMQVGKTLTNGERHDGRAPDYDDWELNGDILVYYPVLDIALELSSMGIRVDEDALDRQLTIAGCDDRRELPFQKAILNKELPYTIGGGIGQSRICMFFLRKAHIGEVHASLWPEEVMKEAAAKGVQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z7L9</accession>
    <name>A0A173Z7L9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Recombination protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199830.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71700">
        <property type="protein sequence ID" value="CUN71700"/>
        <property type="gene ID" value="ERS852478_00870"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN71700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="456" mass="52203" checksum="C2AFC5764553A194" modified="2016-09-07" version="1">MVFRLYWKQAGDRQNMIIRQLNIKNSGEIHDKTLEFSPGINVLYGENESERAIVHTYIKNMFLGDISEAIYDNAVFAAKLKSPTEQDLARELQKFMTGYQGTADSSMNLGRAMQMLKMSRKGYLVQADRKQKETEQERQKLLTRMDDIISDLNDLNGKLDQINEKEESLRMHPGDENGAVILDERMAQAKAKRNSFAMGMLISATAGIFGLILTAIIADSVSVSLIVAVIAAALVGFCGKQQLKYAREFQKRIRMKKRWVSRQEKLRCSKENLRQDYDEKETELCNLKEEYREYEENSFLLTSEEREVQALNMAMETIERMSGNIHLQVGRKLQMRTSQILSEITDGEYQDVQMDAASHMTVTTGNGVEALECLSRGTLELIYFAMRMAAGELLCQEESLPVILDDIFGMYEEEDLEAVLGWMYKEKKQVIISTCSKREMELLDREGIPYGRQIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZAY5</accession>
    <name>A0A173ZAY5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flp pilus assembly protein TadB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852478_00893</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993263.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72355">
        <property type="protein sequence ID" value="CUN72355"/>
        <property type="gene ID" value="ERS852478_00893"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="204"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN72355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="344" mass="39327" checksum="B249738DB8281649" modified="2016-09-07" version="1">MWVHVVIFVMILCALTGWKKGWIPSSGIGGKDGIRLFAVVAIAGNLLGMILTLQNGGQVYPQGYRLEKEDTGSYEKEFMVSVDGEEPVSMYIQVPEKELEEQEEEPKQNKKLTRKEQAQKSIAEAVSRYNEQRSDPDYYYLPDKLNGKKVKWESPADTSGMLLTGLFLIAAMAILVMKGREEQVQLQKRYEELLMDYPGLIMKFTLLVQAGMTVRKAFQKISLDYGRKRKRNPRPAYEEIRIVCYEMESGVSESEAYRRFGERCGQAKYKTFATLLIQNLQKGSRQMADMLERESTEAWEERKRKARVLGEAAATKLLVPMIMMLIVVMAIVMIPAFMSFYGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZGE5</accession>
    <name>A0A173ZGE5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin type III domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060624.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74205">
        <property type="protein sequence ID" value="CUN74205"/>
        <property type="gene ID" value="ERS852478_00953"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016856" evidence="1">
        <location>
            <begin position="30"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="68"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN74205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="335" mass="36601" checksum="49E2CE282917F845" modified="2016-09-07" version="1">MKARSFKKFFVSIALSAVLTLSSASSVFAATAQLAPAEQSVEQAQSDDSDTPAIESSDAQNACASLTAQPGIRQTAASENSVTIQWNPVTNASKYAVNISPLSSSSYRFLGYIGNTRNKAKINKLKAGTAYVIKITALNSSGIAISSRTVGCTTLYSKVKIKSSYASTGRYTFNMQTVNPSNSITGYKVVYQSSAAHKLITKYFNTRYSFTIPISGNTFYQVKIYPYLVLGNKRYVSSTSTDRYISNVITLQKAGNTNSSMSVKWNRTAGADNYSIYIKYPGSSSFKKVKTTTSNFFTLTGMKKNTKYGIKVIANKKMKNKVWHSDSKAYNMSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZML1</accession>
    <name>A0A173ZML1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4832 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76706">
        <property type="protein sequence ID" value="CUN76706"/>
        <property type="gene ID" value="ERS852478_01032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032267">
        <property type="entry name" value="DUF4832"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16116">
        <property type="entry name" value="DUF4832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4832" evidence="1">
        <location>
            <begin position="234"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN76706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="454" mass="52456" checksum="3BE68D3B08FE932F" modified="2016-09-07" version="1">MAKSQKRYLVLLGFGLLVIIAAGVWMVFGRKTQIYEKTEEIFGNPLMGYAPCAWEETIGEDISLLYMDITWAELEPEEGKYDWEKIERENQTDRWREEGKHLVLRFVCDIPGEEKHMDIPQWLYDKTDHAGTWYDMEYGKGYAPDYNNEQMIQYHKRAVNALGEHFGRDGLVSYIELGSLGHWGEWHVNISAGIQSLPEESVRERYMIPWTEAFPDSMILMRRPFSEGEHYGTGLYNDMTGQPESTEEWFRWINEGGEFDQTHEKKGLSAMKDFWKKFPSGGEFTSSITMKELLDTNLDQTINLIKKAHTTFLGPKVADKTYENGYRKVLGSMGYRLWISQASLIQMPGYVSLNLKWKNDGVAAFYEDWPVWVLVEDEDGNSLEKEAVDISLKSLLPEETLQTKTRMQVKKMISLAGKKYKISIGIEDPMTGKLAVRLSMKGTYNEGKNYLFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZRY4</accession>
    <name>A0A173ZRY4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1292 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF1292)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01074</name>
        <name evidence="3" type="ORF">ERS852523_02689</name>
        <name evidence="5" type="ORF">GT712_13575</name>
        <name evidence="4" type="ORF">GT728_14245</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A1</strain>
            <strain evidence="5 8">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000030">
        <property type="protein sequence ID" value="CUP75317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000037">
        <property type="protein sequence ID" value="MZL34327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000028">
        <property type="protein sequence ID" value="MZS90073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707416.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000035_gene3834"/>
    <dbReference type="EnsemblBacteria" id="CUN79202">
        <property type="protein sequence ID" value="CUN79202"/>
        <property type="gene ID" value="ERS852478_01074"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP75317">
        <property type="protein sequence ID" value="CUP75317"/>
        <property type="gene ID" value="ERS852523_02689"/>
    </dbReference>
    <dbReference type="GeneID" id="66496227"/>
    <dbReference type="eggNOG" id="ENOG5032YV4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN79202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP75317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="85" mass="9869" checksum="487DE15CB1091514" modified="2016-09-07" version="1">MEKIKFQLEDGTEAEFYVEEQTRIGGVAYLLVSDSQDDEATAYIFKDVSEDDSQEACYEMVEDEDEMQAVFKVFEQMLDDVDLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZVT0</accession>
    <name>A0A173ZVT0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Melibiose operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">melR_1</name>
        <name evidence="4" type="ORF">ERS852478_01095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79933">
        <property type="protein sequence ID" value="CUN79933"/>
        <property type="gene ID" value="ERS852478_01095"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="182"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN79933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="295" mass="34808" checksum="CBB65294C63016D7" modified="2016-09-07" version="1">MEIKQHGSSDYPFQYYYDNLELFDFHCIEWHWHREFEFLYVESGEVTCGIGEKQIILSEGEAIFINSKILHRFYAPSGGIIPNFVCMPEFIAPENSLIYKKYILPIISSNIYFQRFQTDELWQTKIIQTMIKIMEIQGNEKIRELATLALMQDLWLTFYENVKLSDKGDVQTVDEVAQKRVQLIMQYIHENYNHNLSLDEISSHIGISKSTALNLFHRFLHTTPVNYLIGYRLQAASWLLKNTNKKVKTIAYESGFHNVDYFCRLFKKRYHLTPSEYRCTCLKLLSADPSLQTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A1X2</accession>
    <name>A0A174A1X2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen synthase</fullName>
            <ecNumber evidence="7">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">glgA1_2</name>
        <name evidence="7 11" type="synonym">glgA</name>
        <name evidence="10" type="ORF">ERS852478_01173</name>
        <name evidence="11" type="ORF">GT712_03630</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704084.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82672">
        <property type="protein sequence ID" value="CUN82672"/>
        <property type="gene ID" value="ERS852478_01173"/>
    </dbReference>
    <dbReference type="GeneID" id="66494009"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 7 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_5" evidence="9">
        <location>
            <begin position="3"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="8">
        <location>
            <begin position="293"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN82672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS88203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="482" mass="56090" checksum="CBFEB52D35A6A009" modified="2016-09-07" version="1">MKNILFATSEAVPFIKTGGLADVAGSLPKYFDKRYFDIRVILPKYACMKQEWKDKMNYITHFYMDLGYKNCYVGIMHMEYEGIQFYFIDNEYYFSGPKPYDGGTWDLEKFAFFSKAVLSVLPVIGFRPDIIHCHDWQTGLVPVYLHDSFQQNEFFWNIKTIMTIHNLKFQGVWDVQTIKNITGLSDYYFTADKLEAYKDANYLKGGIVFADAVTTVSNTYAEEIKTPFYGEKLDGLMCARANSLRGIVNGIDYNEFNPETDPYITKTYNATTFRKEKVKNKLQLQRDLGLQEDPKTMMIGIVSRLTDQKGFDLIAYVMDELCQDAIQLVILGTGDERYENMFRHFDWKYHGKVSAQIYYDEKMSHRIYASADAFLMPSLFEPCGLSQLMSLRYGTLPIVRETGGLKDTVVPYNEYEGTGNGFSFRNYNAHEMLATVRNAERIYYDKKREWNKMVDRAMAADFSWGNSARQYEEMYNWLIGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AGJ1</accession>
    <name>A0A174AGJ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation initiation inhibitor protein soj</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">soj_1</name>
        <name evidence="2" type="ORF">ERS852478_01271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199998.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87323">
        <property type="protein sequence ID" value="CUN87323"/>
        <property type="gene ID" value="ERS852478_01271"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN87323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="275" mass="30177" checksum="9764BEE56D78C6B8" modified="2016-09-07" version="1">MSNCKVIALTNQKGGVGKTTTAVNLGVSLVQQGKKVLLIDADAQANLTMALGYNRPDDIPITLSTVMQNIIDDTTLDVSQGIIHHREGVDLLPSNIELSGFEVRLINAMSRERVLKTYVNEVKKNYDYVLIDCMPSLGMITINALAAADSVIIPTQPHYLSAKGLELLLRSVSMVKRQINPKLRIDGILMTMVIPRTNISKEITATVKSAYGKKIKVFDTEIPHSIRAVEATAEGKSIFAYDKSGKVAAAYEQLGKEVAEIGEKQRNQNRADRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AM23</accession>
    <name>A0A174AM23_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sirohydrochlorin cobaltochelatase</fullName>
            <ecNumber evidence="3">4.99.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbiK_2</name>
        <name evidence="3" type="ORF">ERS852478_01339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.99.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200023.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89791">
        <property type="protein sequence ID" value="CUN89791"/>
        <property type="gene ID" value="ERS852478_01339"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016852">
        <property type="term" value="F:sirohydrochlorin cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019251">
        <property type="term" value="P:anaerobic cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010388">
        <property type="entry name" value="Anaerobic_Co-chelatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06180">
        <property type="entry name" value="CbiK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033579">
        <property type="entry name" value="Anaer_Co_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR033579-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR033579-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN89791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="268" mass="30434" checksum="D54B2C3CCC7473C6" modified="2016-09-07" version="1">MGVTEKTAILVISFGTSYEETRKKTIEQIESDLHHVFGKYPLYRAWTSPRIRAKLRKRDGIHIMDIDEAMTQLKADGIRNVIVQPTYVITGFESDAMKEKVLAFKNDFDSIIICDSLMVTRQDKEEVCQAMASEYHPDSDEVLLFMGHGTEHVANELYPEMDGLFKHFGYSNMHMGTVEGDFSIESFLDELKNSHPDHVHLAPFMIVAGDHATNDMSGEDDDSWKSILEKEGYSVKCTLKGLGEIQAIRDIFIRHTRAGLDRLSEIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ATQ1</accession>
    <name>A0A174ATQ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEPN domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200040.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90775">
        <property type="protein sequence ID" value="CUN90775"/>
        <property type="gene ID" value="ERS852478_01372"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SWK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN90775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="144" mass="16652" checksum="5BE479ACB4BB48B4" modified="2016-09-07" version="1">MALNSYFDFAENDFQYFKASYDAGIVANMMGAMAQGICEKYMKHLISEYYKPDDAMQQKDFDNILRTHSLNRLMKFLKGNMGAEFSKNTQTHMRMIDGFYFSTRYPGDDSIEIDGDDVETCNDAIELCRTEVLKLEQKLKKGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B1S4</accession>
    <name>A0A174B1S4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PUA domain (Predicted RNA-binding domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200080.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93720">
        <property type="protein sequence ID" value="CUN93720"/>
        <property type="gene ID" value="ERS852478_01427"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="1">
        <location>
            <begin position="50"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN93720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="258" mass="30209" checksum="81B452593D9DA174" modified="2016-09-07" version="1">MLGRKQSIRNEQQWQEAIDHIEETVSKKELDQLIKVTVKTIKEKCKGKKVAYAWSAGKDSLVLGEICERAGIDQSVLVRCNLEYPAFIEWIDQNKPSGLEIINTGQDLEWLRKHPDMLFPDKSNKAAQWFHIVQHRGQARYYKEHQLEILLLGRRKADGNYVGKDNIYTNSAGITRYSPLAEWRHEDILAYIHYYDVKLPPIYDWEKGYLCGTHPWPARQYMETEQQGWKEVYDIDKTIVENAAQHFDGAREFLKAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BDN6</accession>
    <name>A0A174BDN6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022473970.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97880">
        <property type="protein sequence ID" value="CUN97880"/>
        <property type="gene ID" value="ERS852478_01545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026990">
        <property type="entry name" value="TnpW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14202">
        <property type="entry name" value="TnpW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN97880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="66" mass="7324" checksum="A47F5AAC5678F3B6" modified="2016-09-07" version="1">MNNDTSNRSTPATASPLTVKEAAPPVMIKKIGKTTYRVKIHFSETSKETMSDKIKRLILNDSEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BED2</accession>
    <name>A0A174BED2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamine-phosphate synthase</fullName>
            <shortName evidence="8">TP synthase</shortName>
            <shortName evidence="8">TPS</shortName>
            <ecNumber evidence="8">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="8">TMP pyrophosphorylase</shortName>
            <shortName evidence="8">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">thiE_1</name>
        <name evidence="8" type="synonym">thiE</name>
        <name evidence="12" type="ORF">ERS852478_01553</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8 9">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8 9">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 8 10">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN98120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200143.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98120">
        <property type="protein sequence ID" value="CUN98120"/>
        <property type="gene ID" value="ERS852478_01553"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="11">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="8">
        <location>
            <begin position="37"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN98120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="213" mass="22800" checksum="8B2B7C7BF2B8EA7B" modified="2016-09-07" version="1">MNFDYTLYLVTDRQLMSCDSLTEAVEQAILGGCTMIQLREKELSSLEFYNQAVAVKQVTDKYHIPLIINDRIDIAMAVQATGVHIGQHDLPAAAVRKVIGENMLLGVSASSIAEAIQAQQDGADYLGVGAMFPTGTKTDADSVSMEELQKIRTAVSLPIVVIGGINKGNTGRFKPMGIDGLAVVSAIIAQSDIKAAAAELKDLFCGKEKKHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BR54</accession>
    <name>A0A174BR54_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Queuosine ECF transporter S component QueT</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Queuosine transporter QueT</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">queT</name>
        <name evidence="4" type="ORF">BWLFYP14_00243</name>
        <name evidence="2" type="ORF">ERS852478_01645</name>
        <name evidence="3" type="ORF">GT712_09050</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707233.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02170">
        <property type="protein sequence ID" value="CUO02170"/>
        <property type="gene ID" value="ERS852478_01645"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010387">
        <property type="entry name" value="QueT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40044">
        <property type="entry name" value="PTHR40044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06177">
        <property type="entry name" value="QueT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031501">
        <property type="entry name" value="QueT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO02170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS89215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX67402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="165" mass="17716" checksum="910D22D07548E25B" modified="2016-09-07" version="1">MKNKGTQFLTEAAVIGAIYVVLTLLFAPLSYGEIQIRFSEALTILPFFTPAAIPGLFVGCIIANLFGGAIPVDIIFGSIATLIGAVFTYRLRSCNRFLAPIPPIVSNAVIVPFVLHFGYGVNLPIPLMMLTVGIGEVVSCGVVGLILQTALLKYKNVIFRSQRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BYM0</accession>
    <name>A0A174BYM0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromate transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Chromate transporter, chromate ion transporter (CHR) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_01744</name>
        <name evidence="9" type="ORF">GT712_12145</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200214.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06202">
        <property type="protein sequence ID" value="CUO06202"/>
        <property type="gene ID" value="ERS852478_01744"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO06202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="188" mass="20310" checksum="1D063168B684181B" modified="2016-09-07" version="1">MENKKNVLWKLFISALYLSAFTFGGGYVIVTLMKKKFVDDYHWIEENEMLDLVAIAQSSPGPIAVNGAIVVGYKLAGMPGVLVAIIGTIIPPFLIISVISVCYNAFRSNYFVSQMLEGMQAGVGAVIASVTYEMGAGIVQDKNGISTVIMVGAFIASCIFEVNVVYVVIVCGLIGVIRTCIAKRRKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C274</accession>
    <name>A0A174C274_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">rpmG</name>
        <name evidence="6" type="ORF">BWLFYP14_01184</name>
        <name evidence="5" type="ORF">ERS852478_01771</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07053">
        <property type="protein sequence ID" value="CUO07053"/>
        <property type="gene ID" value="ERS852478_01771"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO07053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX63825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="75" mass="9044" checksum="315235754FFCAF47" modified="2016-09-07" version="1">MPEKMTDTSSGMRKMTMQMKTLEVEVVRVKITLACTECKQRNYNMTKEKKNHPERMETQKYCKFCRKHTLHKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C2I7</accession>
    <name>A0A174C2I7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200262.1">
        <property type="nucleotide sequence ID" value="NZ_JADPFJ010000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07721">
        <property type="protein sequence ID" value="CUO07721"/>
        <property type="gene ID" value="ERS852478_01792"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018850" description="Beta-lactamase2 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="3">
        <location>
            <begin position="139"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO07721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="308" mass="33026" checksum="F388C0802A7C2F92" modified="2016-09-07" version="1">MFSKKLLIPLLSLSLLVTPAYSSHAAENAEAAETSVEGQGMLSPSSSSESSESVFNGSGAGTSSEPVTDEKLETILKQVQSQLPAENGTWAVFISDLVNGTEGSLNDQKMQAASLIKLYIMGAVYENYDQITGQYGRDSVDSNLYSMITVSDNDAANTLTTYLGGGDSAAGMQAVNSFCQAHGYDQTHMGRMLLASNENDDNYTSVGDCGHLLQEIYKQDTSGYTHAADMFNLLKAQTRCNKIPAQLPEGVKTANKTGELDNVENDAGIIYDSKNDVVIVFMSQNLSSAGSAQNTIATLSRTIYDYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C610</accession>
    <name>A0A174C610_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LPS biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200258.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07198">
        <property type="protein sequence ID" value="CUO07198"/>
        <property type="gene ID" value="ERS852478_01776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="718"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO07198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="808" mass="94878" checksum="07BD8336F53A2FF4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CFE5</accession>
    <name>A0A174CFE5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD phosphatase, family IIIA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Phosphoglycolate phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.18</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">YqeG family HAD IIIA-type phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gph_2</name>
        <name evidence="5" type="ORF">BWLFYP14_02226</name>
        <name evidence="2" type="ORF">ERS852478_01903</name>
        <name evidence="3" type="ORF">ERS852523_01957</name>
        <name evidence="4" type="ORF">GT728_10820</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.18" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000018">
        <property type="protein sequence ID" value="CUP54175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000023">
        <property type="protein sequence ID" value="MZL33678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703523.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000004_gene1943"/>
    <dbReference type="EnsemblBacteria" id="CUO11874">
        <property type="protein sequence ID" value="CUO11874"/>
        <property type="gene ID" value="ERS852478_01903"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP54175">
        <property type="protein sequence ID" value="CUP54175"/>
        <property type="gene ID" value="ERS852523_01957"/>
    </dbReference>
    <dbReference type="GeneID" id="66493891"/>
    <dbReference type="eggNOG" id="COG2179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010021">
        <property type="entry name" value="PGPP1/Gep4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF25">
        <property type="entry name" value="PTHR19288:SF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01668">
        <property type="entry name" value="YqeG_hyp_ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO11874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP54175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="167" mass="19289" checksum="0D7A98A3777A9A33" modified="2016-09-07" version="1">MFNCFFPDEYLDSTYVINFDDLYAQGYRGLLFDIDNTLVPHGAPADERACALFAHLKELGFKCCFLSNNQYERVSSFNDAIGAQFIENAHKPSTKNYIRAMELLGTDRSNTVFIGDQLFTDIYGAKRTGIRNILVKPLNPKEEIQIVLKRYLERIVLYFYRKEEGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CI53</accession>
    <name>A0A174CI53_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized Nudix hydrolase yfcD</fullName>
            <ecNumber evidence="2">3.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yfcD</name>
        <name evidence="2" type="ORF">ERS852478_01889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200423.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11458">
        <property type="protein sequence ID" value="CUO11458"/>
        <property type="gene ID" value="ERS852478_01889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO11458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="186" mass="21267" checksum="A533286ED987300D" modified="2016-09-07" version="1">MELFDVIDSKGNPAGQIVSREKAHAEGIPHRTAHIWIIRKKEGRVQILLQKRSQNKDSFPGKFDTSSAGHIQAGDEPLESALRELKEELGISATPEQLHFAGTFPISFAKEFHGKMFRDEEIAFVYIYREPVNTAELVLQTEEVEEVQWFDLEEVYEQCGKHREIFCVPALGLGVVRRYLKSIEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CJ05</accession>
    <name>A0A174CJ05_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12927">
        <property type="protein sequence ID" value="CUO12927"/>
        <property type="gene ID" value="ERS852478_01934"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="110"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO12927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="383" mass="44772" checksum="20AAAA3D9C30DA28" modified="2016-09-07" version="1">MFHVKLKDTLKHSIANVTSHMDSFVYNPGRDYSRIRKLSPDHVISFLISQGTSSTKCEFLDFFQMSEDLPSISALNQRRSQMMPEALEAVFHEFTSSSEKLELSRQEQQYQYIAADGSTTSFFSFSKYSSDDYFISEGHSASGFYSMHINAFYDINKRIYTDAILQSAHKKDEFLAFCQLVDRHIPHPDQRTIFIGDRGYCSYNNMAHVIEKEQYFVFRTKDITSKGLIGNFVFPDSDTFDITVDVTLTRSHRKSIKIKDGFYRRYVDQAASFDYIKYGSEDTYDLTFRIVRFPISEDTYECLVTNLPKKNFPVEKLKEIYNSRWGIESSFRKLKYTIGLSHYHSYKPDFIKQEIWAKFIAYNATELLVAHTVVVHGKRKYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CKL9</accession>
    <name>A0A174CKL9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xerC_1</name>
        <name evidence="8" type="ORF">ERS852478_01966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13932">
        <property type="protein sequence ID" value="CUO13932"/>
        <property type="gene ID" value="ERS852478_01966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="7">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="112"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO13932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="315" mass="37010" checksum="AB09B1D31235030C" modified="2016-09-07" version="1">MLKFLYILFYLAQQVKLVSYLEYCTYRKELDQKTVKAYRIDLNQYFTFVACEEPDKEKIEEYITELHKKYKQKTVKRKIASVKAYYSYLEENELIKESPFRKIKVKFKENLILPRIIPREEIEHLLNHMYGCLQQASETVYKYCLRDVAVIELFFATGARVYEISNIRAENVNLNTGLIQLMGKGAKERYVQIGSTSVLNILRKYYAENRAAIKKSGYFFVNGRGNRYTEQSIRLMLKKYTAQAGIERNITPHMFRHSFATYLIEEGVDISCVQRILGHSSIKTTQIYIHVAARKQAEILRDMHPRNNMKIIGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CNC8</accession>
    <name>A0A174CNC8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nirC</name>
        <name evidence="6" type="ORF">ERS852478_01972</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO14822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707502.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO14822">
        <property type="protein sequence ID" value="CUO14822"/>
        <property type="gene ID" value="ERS852478_01972"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO14822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="251" mass="26949" checksum="88B7FB0748416971" modified="2016-09-07" version="1">MNYEDVQKVSNAAKAKSNLVNTNFFKYFIRAVMAGFFIDVAMIYSNVVGNVFSKTMPEWGKFVGALVFSIAVLLISFVGGELFTGNNMVMAFGAYDKQVSWKEAGKVWGVSYLGNFVGCAILALLFVGAGASGTADYFAGFIGNKLSIPLGQMFFRAVLCNFFVCLGVLCGMKLKSDAGRFLMIVMCISGFVVSGFEHCIANMGIFVTAYCLVPGLSLGAMVKSMVVVTLGNMVGGALLLAWPLRKMSADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CXC1</accession>
    <name>A0A174CXC1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="4">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="4">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">truB</name>
        <name evidence="7" type="ORF">ERS852478_02020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16415">
        <property type="protein sequence ID" value="CUO16415"/>
        <property type="gene ID" value="ERS852478_02020"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="5">
        <location>
            <begin position="23"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="6">
        <location>
            <begin position="172"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO16415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="294" mass="32749" checksum="009CBD9083C6EBA6" modified="2016-09-07" version="1">MDGVIVIRKEKGFTSHDVVAKLRGILHMKKIGHTGTLDPDAEGVLPVALGKATRLVDMITDKEKTYEAVMRLGVVTDTQDMSGTVLSQTTELSVTEEELCTVVSSFVGDYMQVPPMYSALKVNGKKLYELAREGKTVERKPRPVHFYEIEILDISFPLVRFRVTCSKGTYIRTLCHDIGEKLGCGAAMESLLRTKVGRFTLDDAITLAQTEEAVQEGTIESKILGIEEILAEYPRVCCTKEGDRLLANGNPLVQALVDAQEKNGWIRMCSSEGGFAGVYQWDEKRNRYFPVKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D6N8</accession>
    <name>A0A174D6N8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA segregation ATPase FtsK/SpoIIIE and related proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200580.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20897">
        <property type="protein sequence ID" value="CUO20897"/>
        <property type="gene ID" value="ERS852478_02144"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="215"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="232"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO20897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="463" mass="53062" checksum="7323AAFEAEF4E36B" modified="2016-09-07" version="1">MKVWKKSKGNRIRASDKSLVYHFCIGWLLLLFIAVFLLLNLRQLLVTDWKDFNLLHAGITWTAYNSITVLIATGVCALVAFLYYRYGYDRIKRLLHRQKLARMVLENKWYEAENTKDSGFFTDLQSRSREKIVWFPKIYYQMDNGLLHILCEITMGKYQEQLLSLEDKLESGLYCELTDKTLHDGYIEYTLLYDMIANRISIDEVVAENGGLRLMKNLVWEYDSLPHALICGGTGGGKTYFLLTIIEALLKTNADLYILDPKNADLADLGTVMGNVYHTKDDMIDCVNAFYEGMVTRSEEMKLHPNYRTGENYAYLGLAPQFLIFDEYVAFLEMLTTKESTALLSQLKKIVMLGRQAGYFLIVACQRPDAKYFGDGIRDNFNFRVGLGRLSELGYGMLFGSDVKKQFFQKQIKGRGYCDVGTSVISEFYTPLVPKGYDFLGTIGELAGRRTEKKALEQSEALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D831</accession>
    <name>A0A174D831_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphatidylglycerophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">pgsA_1</name>
        <name evidence="18" type="ORF">ERS852478_02122</name>
        <name evidence="19" type="ORF">GT712_11550</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 20">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein catalyzes the committed step to the synthesis of the acidic phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053943.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20205">
        <property type="protein sequence ID" value="CUO20205"/>
        <property type="gene ID" value="ERS852478_02122"/>
    </dbReference>
    <dbReference type="GeneID" id="66495363"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006655">
        <property type="term" value="P:phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CUO20205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MZS89690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="190" mass="21217" checksum="3A86A7B4C3E87627" modified="2016-09-07" version="1">MQSEVNQEENLNRIITVPNLLSFFRLCLIPVIIWSYCVKKNPLLAGEILLLSGLTDLADGYIARRFHRISNLGKILDPVADKLTQAAMLICLFTRFPHVLLLIVIMAGKELYMVVSGCLVIQKTGKVHGADWHGKIVTFLLYGTAAVHIIWFHITPMVSDLLIGLCAIMMVISVALYIIQNTRTLKGETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D954</accession>
    <name>A0A174D954_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Stage III sporulation protein J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">misCA</name>
        <name evidence="9" type="ORF">ERS852478_02184</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22161">
        <property type="protein sequence ID" value="CUO22161"/>
        <property type="gene ID" value="ERS852478_02184"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO22161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="431" mass="47619" checksum="522B088A89D6D65F" modified="2016-09-07" version="1">MEMILATKSSTPIIGQLATVMGWIMDGIYRLLNIFGIQNIGLCIVIFSILIYALMTPLQIKQQKFSKLSAIMQPELQKIQKKYKGKNNDTAAMQKMQEETQAVYQKYGVSPTGSCVQLAIQFPILMALYQVIYKIPAYVGSVRDILASAVTSITGVNGYTDILQQFITDNKMTRVQLIMDGSKATSNSVTDFLYALSPSQWKTLAETSQFAGFTDTLNSTAKEISHVQNFFGLNIADQPLTYIKAAFVGGSALLAIVAILIPILAWATQMINLKLMPQAAQQSGDSQQDAMMNSMKTMNMVMPLMSAVFCFTFPVGLGIYWVASAAVRSVQQVVINKKMDKIQIEDLISENMKKMEKKREKAGLPPQKITNQAHQSAKNINKIEKGSSNTNVETRAKKVEEAYKDAANAKPGSITAKANLVKAFDERNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DBW1</accession>
    <name>A0A174DBW1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO23034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380444.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23034">
        <property type="protein sequence ID" value="CUO23034"/>
        <property type="gene ID" value="ERS852478_02213"/>
    </dbReference>
    <dbReference type="GeneID" id="66493404"/>
    <dbReference type="eggNOG" id="ENOG5033RSK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019905" evidence="1">
        <location>
            <begin position="30"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO23034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="185" mass="21092" checksum="BE3CFC34BDEF38ED" modified="2016-09-07" version="1">MKKWYRYLAAGVLVLLTLCVAGCGGVSHKSPEKVTEELIQSYTDGKEKKVKECYNQVDNTEADLQTEITATLKYFAAHNPKKVSVQDCEILSENDKYSYVYITYNLILEDDQEYPCVGTYMVGKQDKTYYIMAPSQITDDMKTQAATAYVQFMKTDAYKTYTKAYETFIKKNPGYEDKISEKAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DHT8</accession>
    <name>A0A174DHT8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Predicted outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_02263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200663.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25043">
        <property type="protein sequence ID" value="CUO25043"/>
        <property type="gene ID" value="ERS852478_02263"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041033">
        <property type="entry name" value="Prealbumin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041100">
        <property type="entry name" value="TQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00746">
        <property type="entry name" value="Gram_pos_anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17802">
        <property type="entry name" value="SpaA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18202">
        <property type="entry name" value="TQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020017" evidence="6">
        <location>
            <begin position="30"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="986"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="7">
        <location>
            <begin position="977"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="930"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="619"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="930"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO25043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1014" mass="111622" checksum="9D034FC59B3FC4BC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DMP7</accession>
    <name>A0A174DMP7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993368.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25170">
        <property type="protein sequence ID" value="CUO25170"/>
        <property type="gene ID" value="ERS852478_02267"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020110" evidence="3">
        <location>
            <begin position="27"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="877"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO25170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="902" mass="97014" checksum="49B37A5CACA15A32" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DR80</accession>
    <name>A0A174DR80_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="8">S12 MTTase</shortName>
            <shortName evidence="8">S12 methylthiotransferase</shortName>
            <ecNumber evidence="8">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">rimO</name>
        <name evidence="12" type="ORF">ERS852478_02341</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200696.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28092">
        <property type="protein sequence ID" value="CUO28092"/>
        <property type="gene ID" value="ERS852478_02341"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="140"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="9">
        <location>
            <begin position="373"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO28092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="445" mass="50496" checksum="E4C1CB62355AA8B6" modified="2016-09-07" version="1">MKLLFVSLGCDKNLVDSEEMLGLLTGNGFEIVDDETEAEAIVVNTCCFINDAKEESVNTILEMAEYKKTGSCKVLVVTGCMAQRYKNEIIEEVPEVDAVLGTTSYGDILKAIREAMEGKHFQEFKDIDYLPEKLGKRVLTTGGHFGYLKIAEGCDKHCTYCIIPKLRGKFRSVPMERLVTQAKEMAEEGVKELILVAQETTVYGTDIYGKKSLHILLKELCKIKGIRWIRVLYCYPEEIYDELIQTIKEEKKICHYLDLPIQHASDRILKRMGRRTTQAELVEIVNKLRREIPDIVLRTTLISGFPGETQEDHEELMSFVDEMEFDRLGVFTYSPEEDTPAATMPDQVAEEVKEARRDEIMELQQEISYDKGTDRIGQELLVMIEGKVADESAYIGRTYGDAPKVDGYIFVQTGELLMTGDFAKVRVTGALEYDLIGELADEYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E2R7</accession>
    <name>A0A174E2R7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_02164</name>
        <name evidence="1" type="ORF">ERS852478_02457</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32192">
        <property type="protein sequence ID" value="CUO32192"/>
        <property type="gene ID" value="ERS852478_02457"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZIU3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO32192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX65799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="54" mass="6463" checksum="E604CA5BDD7A3A97" modified="2016-09-07" version="1">MEIDFIQELKKRDELLDGYLRQIEIQEEFIQKQKELIECLEDHISKITDIVGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EC19</accession>
    <name>A0A174EC19_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidoglycan synthase FtsI</fullName>
            <ecNumber evidence="7">2.4.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsI</name>
        <name evidence="7" type="ORF">ERS852478_02559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transpeptidase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200789.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35402">
        <property type="protein sequence ID" value="CUO35402"/>
        <property type="gene ID" value="ERS852478_02559"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007887">
        <property type="entry name" value="MecA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05223">
        <property type="entry name" value="MecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="MecA_N" evidence="6">
        <location>
            <begin position="39"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="5">
        <location>
            <begin position="160"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="4">
        <location>
            <begin position="376"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO35402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="700" mass="77960" checksum="9C95982CA3E34969" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ECI6</accession>
    <name>A0A174ECI6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DUF21 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Putative Mg2+ and Co2+ transporter CorB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">yfjD</name>
        <name evidence="13" type="ORF">ERS852478_02527</name>
        <name evidence="14" type="ORF">GT712_02220</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0053 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380371.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33965">
        <property type="protein sequence ID" value="CUO33965"/>
        <property type="gene ID" value="ERS852478_02527"/>
    </dbReference>
    <dbReference type="GeneID" id="66495278"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="208"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="271"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO33965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS87937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="427" mass="48054" checksum="DD7265101FD9D34D" modified="2016-09-07" version="1">MDSSIAFQAVAILILIALSSFFSSAETAMTTVNKIRIQSLAEQGNKRAVILEKIISNSPKMLSTVLIGNNIVNMSVSSLMTTLTIKILGNAYVGITTGILTLLILIFGEITPKNLATIHAEKLSLAYSRIIYGLMILLTPVVFIVNKITEGVLVILHVNPDEKANAMTEHELRTLVNVGEKDGVIENEEKQMIYNVFDFGDSTAKDVMIPRIDMTFIDINFSYDELMAVFSEDMHTRFPVYEDNTDNVIGIINMKDLLVYPKDKPFSIRNILREPYFTYEYKATADLMIEMRKASVNLAIVLDEYGATAGLVTLEDLLEEIVGEIRDEYDEDEVEDIKEIQPEREYVVQGSAKLDDINEALHINLESEDYDSIGGYIIEQLDCLPKEGQSVTLESGIRLVVDRLDKNRIELVHIWLPEKKTETEEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EN71</accession>
    <name>A0A174EN71_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Sucrose-6-phosphate hydrolase</fullName>
            <ecNumber evidence="3 8">3.2.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Invertase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">scrB</name>
        <name evidence="12" type="ORF">ERS852478_02678</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Enables the bacterium to metabolize sucrose as a sole carbon source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.</text>
            <dbReference type="EC" id="3.2.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Glycan biosynthesis; sucrose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="3 8"/>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO39323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200830.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39323">
        <property type="protein sequence ID" value="CUO39323"/>
        <property type="gene ID" value="ERS852478_02678"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00238"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005985">
        <property type="term" value="P:sucrose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006232">
        <property type="entry name" value="Suc6P_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01322">
        <property type="entry name" value="scrB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="10">
        <location>
            <begin position="31"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="11">
        <location>
            <begin position="423"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO39323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="479" mass="55877" checksum="41EF2DCC515BA96C" modified="2016-09-07" version="1">MSTLTKVLERNIKVIEKNADLTEGRFRLGHHLMPPVGWLNDPNGLCWYKGRYHVFFQYAPFDVEGGLKFWGHYTSEDLVDWKYEGTALYPDSPYDCHGVYSGSALAESEKLHLFFTGNVKIDGDYDYINEGRETSTLHVESEDGIHFGDKEEIISFEKYPEEFTCHIRDPKVWKENDRYFMVLGGRLKGDKGAVLVYESENLKEWKFKHIITTPEAFGYMWECPDYFELDGKKFLSVSPQGLKREEFRFQNIYQSGYFPVKEDGSVDERDFREWDMGFDFYAPQTFTDNSGRRLLIGWMGMPDAEEEYTNKTIDEGWQHCLTVPRELRVKDGKIFQYPAKELERLRKEKTILDDEKSIVEVRVEVNEGFDLLIEDIAVTDRSFQISMGGQMLFKYENEIAEIGFSEIAGAGRNKRKAKVSELNNIRILADTSAVELYLNDGEIVFSTRYYPDHEDLQLKVKGGKFRGNLWNLRKMIFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EQS1</accession>
    <name>A0A174EQS1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ftsH_2</name>
        <name evidence="7" type="synonym">ftsH</name>
        <name evidence="10" type="ORF">ERS852478_02701</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200844.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40273">
        <property type="protein sequence ID" value="CUO40273"/>
        <property type="gene ID" value="ERS852478_02701"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="197"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="205"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO40273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="617" mass="67582" checksum="7FE184A14728F4CA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ETQ3</accession>
    <name>A0A174ETQ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yehU_5</name>
        <name evidence="10" type="ORF">ERS852478_02693</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379943.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40038">
        <property type="protein sequence ID" value="CUO40038"/>
        <property type="gene ID" value="ERS852478_02693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="300"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="463"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO40038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="564" mass="64718" checksum="2F935D8A0DEE01E0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F301</accession>
    <name>A0A174F301_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ftsH_3</name>
        <name evidence="7" type="synonym">ftsH</name>
        <name evidence="11" type="ORF">ERS852478_02842</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200959.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44722">
        <property type="protein sequence ID" value="CUO44722"/>
        <property type="gene ID" value="ERS852478_02842"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7 11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="10">
        <location>
            <begin position="217"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="225"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO44722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="656" mass="72147" checksum="7D09707AE4971B09" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F5B3</accession>
    <name>A0A174F5B3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200985.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44747">
        <property type="protein sequence ID" value="CUO44747"/>
        <property type="gene ID" value="ERS852478_02843"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4868">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014999">
        <property type="entry name" value="UPF0371"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08903">
        <property type="entry name" value="DUF1846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033132">
        <property type="entry name" value="DUF1846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO44747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="493" mass="55154" checksum="4E40360BEDB7B5C1" modified="2016-09-07" version="1">MKIGFDNDKYLKMQSEHIRERINQFGNKLYLEFGGKLFDDYHASRVLPGFEPDSKLRMLMQLSDQAEIVIVISAADIDKNKVRGDLGITYDEDVLRLMEVFTERGLYVGSVCITQYSGQESADAFKKRLEKLGIKVYVLYLIPGYPNNTSFIVSDEGYGKNDYIETTRPLVVITAPGPGSGKMAACLSQLYHEYKRGVKAGYAKFETFPIWNIPLKHPVNLAYEAATADLNDVNMIDPFHLEAYGETTINYNRDVEVFPVLQAMFEKIMGECPYKSPTDMGVNMAGNCIVDDEVCKEAARQEIIRRYYKSMEALVRGTGREEEVYKIELLLKQAHVTIEERKVVPAALKREEETGAPAAALELPDGRIVTGKTSELLGASSALLLNALKELAGIDHDKHVISPEALRPIQALKTEYLGSKNPRLHSDETLIALSISAADNEDAKLALQQIPKLKGCQVHTSVLLSQVDILEFRKLGVELTCEPKSEHAKKLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FA03</accession>
    <name>A0A174FA03_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rpsG</name>
        <name evidence="12" type="ORF">BWLFYP14_03390</name>
        <name evidence="10" type="ORF">ERS852478_02925</name>
        <name evidence="11" type="ORF">ERS852523_03099</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">2789STDY5834863</strain>
            <strain evidence="11 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000039">
        <property type="protein sequence ID" value="CUP87002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000065_gene676"/>
    <dbReference type="EnsemblBacteria" id="CUO47142">
        <property type="protein sequence ID" value="CUO47142"/>
        <property type="gene ID" value="ERS852478_02925"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP87002">
        <property type="protein sequence ID" value="CUP87002"/>
        <property type="gene ID" value="ERS852523_03099"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO47142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP87002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX67113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="156" mass="17848" checksum="22267F2BB7F32F04" modified="2016-09-07" version="1">MPRKGHTQKRDVLADPMYNNKVVTKLINNIMLDGKKGVAQKIVYGAFARIEEKAGKPALEVFEEAMNNIMPLLEVKARRIGGATYQVPIEVRADRRQALALRWLTMFSRKRGEKTMEERLANELLDAMNNTGASVKRKEDMHKMAEANKAFAHYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FEJ1</accession>
    <name>A0A174FEJ1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">malQ_2</name>
        <name evidence="8" type="ORF">ERS852478_02971</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201038.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48742">
        <property type="protein sequence ID" value="CUO48742"/>
        <property type="gene ID" value="ERS852478_02971"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO48742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="490" mass="56711" checksum="16205FD4428FDC9A" modified="2016-09-07" version="1">MRKAGVLMPVSALPSRIGAGELGESAFQFIELLKENHVKIWQILPLNPVGYGNSPYQPYSSCAGDELYISLDALAEEGLLKEHPKEFQERATRVDYEAVRQYRVPFLRTAFDVFTEKKGQEETAYKEFASQEWVYEYGVFRALKKTNNGECWNDWPEEYRTWPENRQKLPAEVEIEAQYQMFLQYIFYTQWMKVKKAANDAGIQIMGDVPFYVGQDSVDVWGGKDNFLLDTDGRPIFIAGVPPDYFSATGQRWGNPIYDWEHMKEQDYRFWVDRIGYSNKLFDIIRIDHFRAFDTYWKIPADCPTAIDGEWIEAPGYEVIDTLQKEIPGLDLVAEDLGLLRPEVLMLKDHYHLKGMKILIFSIETGGKYARDTFHDVENMIFYTGTHDNDTIMQWYGNMSAAARRKIRRMLKKAGASQGSVKDRFLQYTMQNQAEYAIIPLADILGLGKEGHINTPGTIGSPNWEWHLPDFIQAKKELQKFGRLIVDTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FJC7</accession>
    <name>A0A174FJC7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Glutathione-binding protein GsiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gsiB_2</name>
        <name evidence="4" type="ORF">BWLFYP14_03595</name>
        <name evidence="3" type="ORF">ERS852478_02955</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48235">
        <property type="protein sequence ID" value="CUO48235"/>
        <property type="gene ID" value="ERS852478_02955"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252786" evidence="1">
        <location>
            <begin position="27"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="89"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO48235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX67320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="536" mass="59536" checksum="90EF2119037606CF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FNJ0</accession>
    <name>A0A174FNJ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Aminotransferase/MSMEI_6121</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Putative aminotransferase MSMEG_6286</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_03536</name>
        <name evidence="1" type="ORF">ERS852478_03021</name>
        <name evidence="2" type="ORF">GT712_01485</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380885.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50426">
        <property type="protein sequence ID" value="CUO50426"/>
        <property type="gene ID" value="ERS852478_03021"/>
    </dbReference>
    <dbReference type="GeneID" id="66495459"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024551">
        <property type="entry name" value="AspAT_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12897">
        <property type="entry name" value="Asp_aminotransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO50426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS87796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX67261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="429" mass="47580" checksum="7969E50958E7E319" modified="2016-09-07" version="1">MKKYSDMSKEELLTLKAQLDKEYADIKAKGLALDMSRGKPSADQLDLSMGLMNVLSSDSDLKCETGVDCRNYGVIDGIPEAKRLLGEMSEVDPDHIIIYGNSSLNVMFDSIARSMTQGVMGNTPWCKLDKVKFLCPVPGYDRHFKITEFFGIEMINVPMTPQGPDMDMVEKLVSEDASIKGIWCVPKYSNPQGYTYSAETVERFAHLKPAAPDFRIYWDNAYSIHHLYDDNQDFLVEILEACAKAGNPDLVYKFTSTSKVSFPGSGIAAVAASKANLEDFRSYMQIQTIGHDKLNQLRHVKFFKNIDGLHEHMRKHAAILRPKFEMVLNTLDRELGGLGIGEWTKPHGGYFISFDSMEGCAKAIVAKAKEAGVVLTGAGATYPYGKDPKDSNIRIAPSFPTPEDLGKAAEVFVLCVKLTSVEKLLATVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FNN1</accession>
    <name>A0A174FNN1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Acylphosphatase</fullName>
            <ecNumber evidence="3 5">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yccX</name>
        <name evidence="8" type="ORF">ERS852478_03043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 5"/>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51331">
        <property type="protein sequence ID" value="CUO51331"/>
        <property type="gene ID" value="ERS852478_03043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="7">
        <location>
            <begin position="73"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO51331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="157" mass="18273" checksum="35C02F69E350A174" modified="2016-09-07" version="1">MRMFGKSSCRHSSCERGLLLSIFDFKKKKYRTFLQDSETGADDTREYERGRGVWGKNNLQEGHGSEMSENLIRKHYWFSGRVQGVGFRYRACYIASSLGVTGWVRNNWDERVEMEAQGTREDLARMVEMLYRQSFIGIEGVEEKVVPVEVESGFYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FTG2</accession>
    <name>A0A174FTG2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002595106.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPF010000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53534">
        <property type="protein sequence ID" value="CUO53534"/>
        <property type="gene ID" value="ERS852478_03110"/>
    </dbReference>
    <dbReference type="GeneID" id="57969716"/>
    <dbReference type="GeneID" id="64114875"/>
    <dbReference type="GeneID" id="66495704"/>
    <dbReference type="eggNOG" id="ENOG502ZCDJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO53534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="138" mass="15161" checksum="0F8356549A4A7231" modified="2016-09-07" version="1">MKKRLLILMTVTGMIILLGGLLTYGLGVHEIIPVPRPDLIVVGTSLIGILLIVSGVCDLFVKKTKEMEIEENDERNISLSNAAMASGFKVMNVTIAVSIFALIFTGYMTVVPCFTIIGAYAIGQIVFIVRLWYLHKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FUA4</accession>
    <name>A0A174FUA4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PrgI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201163.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53321">
        <property type="protein sequence ID" value="CUO53321"/>
        <property type="gene ID" value="ERS852478_03103"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024414">
        <property type="entry name" value="Uncharacterised_PrgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12666">
        <property type="entry name" value="PrgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO53321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="134" mass="15128" checksum="A51CE8412D52D58A" modified="2016-09-07" version="1">MAYVPVPKDLSKVKTKVAFNLTKRQILCFSVALLMGLPLFFLLKDSAGTSLAAMAMIVVMLPCFLVAMYEKHGQPLEVVIKNIIQTKFTRPKVRPYQTENLYALLEKQRALEKEVSAIVKRTDKKDAGSRRKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FXE8</accession>
    <name>A0A174FXE8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator PadR-like family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, Acidobacterial, PadR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_00690</name>
        <name evidence="2" type="ORF">ERS852478_03153</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO54893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000015">
        <property type="protein sequence ID" value="VUX62941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201207.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000098.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54893">
        <property type="protein sequence ID" value="CUO54893"/>
        <property type="gene ID" value="ERS852478_03153"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO54893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX62941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="175" mass="19866" checksum="98C70C258EE24F36" modified="2016-09-07" version="1">MATIDLIVLGILKKEPMSAYDIQKLVEYRNISKWVKISTPSIYKKAIQLEEKGLIRGEIVKEGKMPEKAIYSLTEAGEAEFERLMFEISGKPINIFLDFNAVIVNLDSLPPEKQKSCIAEIEENISTLKSYLEHNIQKKENEPSIPATGMAVLRQQYVLVEAIQAWIASLKKNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FZ76</accession>
    <name>A0A174FZ76_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Resolvase, N terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_03105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005335872.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53405">
        <property type="protein sequence ID" value="CUO53405"/>
        <property type="gene ID" value="ERS852478_03105"/>
    </dbReference>
    <dbReference type="GeneID" id="60774208"/>
    <dbReference type="GeneID" id="64114880"/>
    <dbReference type="GeneID" id="66495709"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025378">
        <property type="entry name" value="DUF4368"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14287">
        <property type="entry name" value="DUF4368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="21"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="177"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="407"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO53405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="556" mass="64674" checksum="C0348F231CFC608C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G7Q3</accession>
    <name>A0A174G7Q3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03247</name>
        <name evidence="3" type="ORF">ERS852523_01255</name>
        <name evidence="4" type="ORF">GT712_08785</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO58031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP32417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019162467.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58031">
        <property type="protein sequence ID" value="CUO58031"/>
        <property type="gene ID" value="ERS852478_03247"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP32417">
        <property type="protein sequence ID" value="CUP32417"/>
        <property type="gene ID" value="ERS852523_01255"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033QQG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014251362" evidence="1">
        <location>
            <begin position="27"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP32417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="235" mass="26253" checksum="4494847D371B8767" modified="2016-09-07" version="1">MNNVKILCIAGSIVLGSILLSGQAFGKAPSDLITLSAPKEPEGQHVSYDIDGSGSYYDSESDTTYYFVKGIVTSYSNHTKTFSLTSDVGETYELPADTDINITDYLNTEAHIWYSEDSQKNLKLLVFSPQIFWEHINELESDEQIPDGATEIDGTLSKYISFWLTEDKIDVTLLFVEDNDGNTHIYAEDNTCNNCNSSVFGKTIGDYIKLYEDMHLNSQVYDDFNVAYLISEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G860</accession>
    <name>A0A174G860_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="13">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">leuB_2</name>
        <name evidence="13 18" type="synonym">leuB</name>
        <name evidence="20" type="ORF">BWLFYP14_02242</name>
        <name evidence="16" type="ORF">ERS852478_03202</name>
        <name evidence="17" type="ORF">ERS852523_01941</name>
        <name evidence="19" type="ORF">GT712_14580</name>
        <name evidence="18" type="ORF">GT728_18235</name>
    </gene>
    <organism evidence="16 21">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 21 22" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 21">2789STDY5834863</strain>
            <strain evidence="17 22">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="18 24 25" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 25">BIOML-A1</strain>
            <strain evidence="19 24">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="20 23" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="13"/>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000018">
        <property type="protein sequence ID" value="CUP53755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000068">
        <property type="protein sequence ID" value="MZL35063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000032">
        <property type="protein sequence ID" value="MZS90262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703487.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000004_gene1929"/>
    <dbReference type="EnsemblBacteria" id="CUO56655">
        <property type="protein sequence ID" value="CUO56655"/>
        <property type="gene ID" value="ERS852478_03202"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP53755">
        <property type="protein sequence ID" value="CUP53755"/>
        <property type="gene ID" value="ERS852523_01941"/>
    </dbReference>
    <dbReference type="GeneID" id="66493905"/>
    <dbReference type="eggNOG" id="COG0473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01033">
        <property type="entry name" value="LeuB_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="PTHR42979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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            <end position="356"/>
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        </location>
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        </location>
    </feature>
    <feature type="binding site" evidence="13">
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            <position position="251"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
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        </location>
        <ligand>
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        <location>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004762"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO56655.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUP53755.1"/>
        </source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="360" mass="39360" checksum="12726A7707A83B8A" modified="2016-09-07" version="1">MDYKIALIPGDGIGPEIVREAKKVLDKVCEKYGHSFSYSEVLLGGASIDVHGVPLTDEAIATAKSSDAVLMGSIGGDAKTSPWYKLEPSKRPEAGLLAIRKALNLFANLRPAYLYNELRKACPLRDEIIGDGFDMIIVRELTGGLYFGERQTIEENGVKKAIDTLSYNENEIRRIAIKAFEIARKRRNKVTSVDKANVLDSSRLWRKVVEEVAKDYPDVTLEHMLVDNCAMQLVRDPKQFDVILTENMFGDILSDEASMVTGSIGMLSSASLNETKFGLYEPSHGSAPDIAGQDKANPIATILSAAMMLRFSLDMDKEADAVEAAVQKVLTEGYRTGDIMSEGCKLVGTKEMGDLIAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G880</accession>
    <name>A0A174G880_9FIRM</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="3" type="primary">mutX</name>
        <name evidence="4" type="ORF">BWLFYP14_03477</name>
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    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
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        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
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    <evidence type="ECO:0000313" key="3">
        <source>
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    <sequence length="153" mass="17602" checksum="EFDA7B828DAF2818" modified="2016-09-07" version="1">MTITTLCYIENNGKYLMLHRIKKHNDINEGKWIGVGGHAEGQESPEECLLREVKEETGLTLTSYKLRGLVTFISDKCEPELMCVFTANEYIGELTECNEGELYWIDKAVVPTLPTWEGDRVFLDLLLSGDERFFSLKLQYEGEKLVDKQVNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
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    <name>A0A174GD20_9FIRM</name>
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    <gene>
        <name evidence="7" type="primary">srrB_4</name>
        <name evidence="7" type="ORF">ERS852478_03293</name>
        <name evidence="8" type="ORF">GT728_17770</name>
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    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO59477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZL34975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_WWVQ01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59477">
        <property type="protein sequence ID" value="CUO59477"/>
        <property type="gene ID" value="ERS852478_03293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
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    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="90"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO59477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL34975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="299" mass="33046" checksum="FC6880E229D9A9D4" modified="2016-09-07" version="1">MNKTGIVIILLCSLAAAAVVLWERRKVRKTMEEIERMLDAAMTGSFSEITFDESQLSALETKFAHYLSAAEASSRNMAQEKDKIKSLIADISHQTKTPIANLLLYSELLMEETLPASAKENVEALYKQSEKLRFLIDSLVKLSRLENGIISLSPQQASLQPLLESVVEQYAAKASGKGLSIYLYDTDISATFDFKWTAEALANIVDNAIKYTEHGTITISTVNYEMFTRIDISDTGSGIPENEQAKIFSRFYRSNAVQEQEGVGIGLYLARQIISGESGYIKVASVPGKGSTFSIFLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GHX5</accession>
    <name>A0A174GHX5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Uncharacterized ABC transporter ATP-binding protein HI_1252</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_00745</name>
        <name evidence="2" type="ORF">ERS852478_03321</name>
        <name evidence="3" type="ORF">GT728_14605</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000039">
        <property type="protein sequence ID" value="MZL34394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000019">
        <property type="protein sequence ID" value="VUX62996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993702.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60550">
        <property type="protein sequence ID" value="CUO60550"/>
        <property type="gene ID" value="ERS852478_03321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO60550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX62996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="87" mass="9720" checksum="82789F30DC723E6C" modified="2016-09-07" version="1">MIQISNLTKKYGETAVFSNLNYTFENTCIYGLVGRNGAGKTTLLNILSNYDKNYTGVISIDGEKMNKVDYLDMPVAYAMDQPSFLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GMQ4</accession>
    <name>A0A174GMQ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative aliphatic sulfonates transport permease protein ssuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ssuC_4</name>
        <name evidence="7" type="ORF">ERS852478_03371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO62189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62189">
        <property type="protein sequence ID" value="CUO62189"/>
        <property type="gene ID" value="ERS852478_03371"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="42"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO62189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="240" mass="27069" checksum="EEA066F53BDCD10E" modified="2016-09-07" version="1">MAVFFWITIWQFASMYLGQEILLASPVSVVRKLFELSFTGNFWQSVGFSFVRIVTGFLLAMFLGIFLAVLAYWSKTVEILIAPVIAVVKSTPVASFIILCLIWIPSKNLSVFISFLMVLPVIYTNILEGIRQTDSKILEMAKVFQVNPGRKIRYIYVSQVLPYFLSACRLSLGMCWKAGVAAEVIGVPSGSIGEKLYNAKIYLNTPDLFAWTIVIIVISFVFEKCFLGIVSRVVYMIEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GND8</accession>
    <name>A0A174GND8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative colanic biosynthesis UDP-glucose lipid carrier transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">wcaJ_3</name>
        <name evidence="9" type="ORF">ERS852478_03380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO62688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201390.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62688">
        <property type="protein sequence ID" value="CUO62688"/>
        <property type="gene ID" value="ERS852478_03380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="277"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO62688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="484" mass="55619" checksum="DC35F4671B0CDCEB" modified="2016-09-07" version="1">MYRKKSRGWYKHKDFILIDLACLFMALILAYLIRNGSVRNLFTLGIYRNVMIFVILVDLFLIILFESYKGVLRRGRYQELRSVIRQMILIELASGLYLFTVSGGHTFSRIILYLMGIIYVLLSYCTRIIWKKRLLHKMAEGGEHSLYIVTNYDLASKVIQNVKEHNYNRYNINGLILIDKDMTGKEIAGVPVVADLNNASSFICQQWVDEVFVNVDETYPYPQELIEELLEMGMPVHVNLAKVRSTPGQKQFVEAIGGYTVLTTTMNYATDRQALAKRVLDILGGLVGCFLTGIIFIFIAPAIYISSPGPIFFSQTRIGKNGKPFKMYKFRSMYMDAEERKAELMAQNKMSDGRMFKLDFDPRVIGNKILPDGTRKTGIGEFIRKTSLDEFPQFWNVLNGSMSLVGTRPILQDELRQYELHHRARIAIKPGITGMWQVSGRSDITDFEEVVRLDTEYISNWNFGLDIKILFKTVIMVLKREGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GTG6</accession>
    <name>A0A174GTG6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_02273</name>
        <name evidence="1" type="ORF">ERS852478_03439</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CUO64346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64346">
        <property type="protein sequence ID" value="CUO64346"/>
        <property type="gene ID" value="ERS852478_03439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO64346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX65908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="539" mass="63042" checksum="AFA3E048B7664A9A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H202</accession>
    <name>A0A174H202_9FIRM</name>
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        <submittedName>
            <fullName evidence="5">Cell division ATP-binding protein FtsE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsE_3</name>
        <name evidence="5" type="ORF">ERS852478_03588</name>
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    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
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    <reference evidence="5 6" key="1">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000039">
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    </dbReference>
    <dbReference type="RefSeq" id="WP_055201452.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69052">
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        <property type="gene ID" value="ERS852478_03588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
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    <dbReference type="GO" id="GO:0005524">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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        <property type="entry name" value="MacB_ATP-bd"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="221"/>
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            <end position="47"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50893"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO69052.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="221" mass="24423" checksum="423C5E7208853B44" modified="2016-09-07" version="1">MSVLQTIDLKKYYGTEPNITRALDGVNFSVNDGEFVAVVGTSGSGKSTLLHMMGGLDTPTSGNVIVRDKELSKMNDEQLTIFRRRNIGFIFQNYNLVPILNVYENIVLPVELDGDTVDQKFLDEIVHLLGLKDKLKNMPNNLSGGQQQRVAIARALITKPAIVLADEPTGNLDSKTSAEVLGLIKRTSAEFRQTVVMITHNDDIARLADRIVRIEDGKIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H2D4</accession>
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        <submittedName>
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        </submittedName>
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    <gene>
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        <name evidence="5" type="ORF">BWLFYP14_01588</name>
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    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
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            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67209">
        <property type="protein sequence ID" value="CUO67209"/>
        <property type="gene ID" value="ERS852478_03528"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="163"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="389"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO67209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="559" mass="65355" checksum="57C75104E9E0BC3C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H966</accession>
    <name>A0A174H966_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Outer membrane-specific lipoprotein transporter subunit LolE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_03619</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO69947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006859032.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69947">
        <property type="protein sequence ID" value="CUO69947"/>
        <property type="gene ID" value="ERS852478_03619"/>
    </dbReference>
    <dbReference type="GeneID" id="61434855"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="648"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="695"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="735"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="277"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="676"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO69947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="775" mass="86430" checksum="13B9CFBC3843601A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H9Y7</accession>
    <name>A0A174H9Y7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">phoR_11</name>
        <name evidence="8" type="ORF">ERS852478_03617</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO69910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006859034.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000122.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69910">
        <property type="protein sequence ID" value="CUO69910"/>
        <property type="gene ID" value="ERS852478_03617"/>
    </dbReference>
    <dbReference type="GeneID" id="61434857"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="130"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO69910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="343" mass="38983" checksum="80E902B611E85AE3" modified="2016-09-07" version="1">MNLNNLSAKKICRLVSAGMVFSMLVITGIFGGIMQDIRIFIVGGTLTLCAFFWIWLLVLIFGKRLSHFTSNLCRTLDNMIDGNEELQKSNDSETLFARINHRLIRLYEIMQKNRHKVDMERQELQMLISDISHQVKTPVSNLQMVTDTLLTKPVSEEERMDFLQGIRSQTDKLDFLFQALVKTSRLETGAIRLEKKDSSLFHTLAQAMSSIVYAAEKKEIAVSVDCPENLIISHDSKWTSEALFNLLDNAVKYTPSGGKISVSVVQWEMYVEVKVTDTGKGISESNQAAIFRRFYREEEVHDQQGVGIGLYLAREIVTRQGGYIKVVSELRQGSEFSIMLPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HAH2</accession>
    <name>A0A174HAH2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03614</name>
        <name evidence="3" type="ORF">ERS852523_01455</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO69845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP38866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053782.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69845">
        <property type="protein sequence ID" value="CUO69845"/>
        <property type="gene ID" value="ERS852478_03614"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP38866">
        <property type="protein sequence ID" value="CUP38866"/>
        <property type="gene ID" value="ERS852523_01455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP38866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="136" mass="15131" checksum="426D7B4B9EB1FE16" modified="2016-09-07" version="1">MKKKIILSIAFIISLLPMFLNQYGELKGVQEITGLINLLNPIGMVSVILFAVGVWFPFKEQVVGKSLGALGTIGIVVSEIYKFFTWHVMNITGEVSIHKSIRFAFPEFYIGLIISILMVVTYFVIDKKVSATSVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HE73</accession>
    <name>A0A174HE73_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">macB_12</name>
        <name evidence="5" type="ORF">ERS852478_03730</name>
        <name evidence="7" type="ORF">GT712_18485</name>
        <name evidence="6" type="ORF">GT728_02325</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">BIOML-A1</strain>
            <strain evidence="7 9">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000045">
        <property type="protein sequence ID" value="CUO73154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000061">
        <property type="protein sequence ID" value="MZS90977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004853372.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73154">
        <property type="protein sequence ID" value="CUO73154"/>
        <property type="gene ID" value="ERS852478_03730"/>
    </dbReference>
    <dbReference type="GeneID" id="42700408"/>
    <dbReference type="GeneID" id="66495304"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO73154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL32067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS90977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="237" mass="26114" checksum="5D6988C6E8223780" modified="2016-09-07" version="1">MKGISEKTLIKIKDLKASVKLNNGDMLTTVTNANMELQRGRSYAIVGKSGSGKTSLISIIGLLNREYEGEYLYDGISISALKDRDLSILRANNIGFVFQNYSLIKHLRVWENIELPLLYAKKSFTAKQRHEIITGLLKSVGLESKENDYPINLSGGEQQRVAIARALAVSPEAILCDEPTGALDKKTGTQIMELLHSVVKENGIMLLLVTHDPDIADTCDTIFEMDGGRITCAKNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HH35</accession>
    <name>A0A174HH35_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfbC</name>
        <name evidence="4" type="ORF">ERS852478_03716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000044">
        <property type="protein sequence ID" value="CUO72697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704436.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72697">
        <property type="protein sequence ID" value="CUO72697"/>
        <property type="gene ID" value="ERS852478_03716"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO72697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="202" mass="22745" checksum="FCB72471AA5025C7" modified="2016-09-07" version="1">MGQIKVEKNVGGIEGLCVIEPAVHGDARGYFMETYNEKDMKEAGIDIHFVQDNQSMSTKGVLRGLHFQKQYPQCKLVRAVRGTVFDVAVDLRSNSETYGKWYGVTLSAENKKQFLIPEGFAHGFLVLSDEAEFCYKVNDFWHPNDEGGMAWNDPEIGIEWPELKGEYKGSASAEGYTLKDGTALNLSDKDQKWLGLKDTFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HLS0</accession>
    <name>A0A174HLS0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SnoaL-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000053">
        <property type="protein sequence ID" value="CUO75854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201538.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000102.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75854">
        <property type="protein sequence ID" value="CUO75854"/>
        <property type="gene ID" value="ERS852478_03815"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO75854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="139" mass="17109" checksum="6130F95DA30B4DC5" modified="2016-09-07" version="1">MNEREKTIRLWFDMWLNQQDMGIDDIFTEDVIYTESWSPQYNNRKTVKHWFQEWNTRGKVVIWEIKQFFHKGDQTIVEWYFKNEMNNGSIEEFDGISLVEWIEDNRIKSLKEFGCNRNTYNPYQEGDTPQFRAEKANWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HVE2</accession>
    <name>A0A174HVE2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000061">
        <property type="protein sequence ID" value="CUO76879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060657.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000061.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76879">
        <property type="protein sequence ID" value="CUO76879"/>
        <property type="gene ID" value="ERS852478_03837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO76879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="130" mass="14789" checksum="EECBB9A123D2585B" modified="2016-09-07" version="1">MSNSNKKNEEKIPIFQSIYCAILFTLIIFRIALKNVGLYINLANYISMVVSIAFVFNASVPKIHPEWRRNLCKSIFLLILLALIIAGFCVLVLNIDIPSILNDIFTLIALMFCVCDKVFESIIIWLASLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J4V5</accession>
    <name>A0A174J4V5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">L-cystine transport system permease protein tcyB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Putative glutamine ABC transporter permease protein GlnP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tcyB_1</name>
        <name evidence="12" type="synonym">glnP</name>
        <name evidence="8" type="synonym">tcyB_2</name>
        <name evidence="12" type="ORF">BWLFYP14_02334</name>
        <name evidence="8" type="ORF">ERS852478_03465</name>
        <name evidence="9" type="ORF">ERS852523_00012</name>
        <name evidence="11" type="ORF">GT712_16605</name>
        <name evidence="10" type="ORF">GT728_16130</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO94623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708209.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000161_gene1324"/>
    <dbReference type="EnsemblBacteria" id="CUO65263">
        <property type="protein sequence ID" value="CUO65263"/>
        <property type="gene ID" value="ERS852478_03465"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94623">
        <property type="protein sequence ID" value="CUO94623"/>
        <property type="gene ID" value="ERS852523_00012"/>
    </dbReference>
    <dbReference type="GeneID" id="66493942"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="22"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO65263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO94623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL34679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS90635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX65964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="225" mass="25520" checksum="1252E250D20678E5" modified="2016-09-07" version="1">MQNMGIEVLFKGINSLRLWQGLWVTIRIALISMVFSIILGFLLGMVMNIPNKIIKFICRIYLEIVRIMPQLVLLFLVYFGAAKHLGMNLSGETAAVIVFTFWGTAEMGDLVRSALISIPKHQYDSGYGLGLNKWQVYLYIILPQTIRRLLPSAVNLLTRMIKTTSLVALIGVVEVLKVGKQIIDASRYTNPTAALWVYGAVFFMYFIICFPFSRLSRVLEKKFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NWF2</accession>
    <name>A0A174NWF2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase III subunit delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00597</name>
        <name evidence="3" type="ORF">ERS852523_01826</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000016">
        <property type="protein sequence ID" value="CUP50325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053020.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000022_gene1749"/>
    <dbReference type="EnsemblBacteria" id="CUN60515">
        <property type="protein sequence ID" value="CUN60515"/>
        <property type="gene ID" value="ERS852478_00597"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP50325">
        <property type="protein sequence ID" value="CUP50325"/>
        <property type="gene ID" value="ERS852523_01826"/>
    </dbReference>
    <dbReference type="GeneID" id="66492494"/>
    <dbReference type="eggNOG" id="COG1466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="17"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN60515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP50325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="328" mass="37645" checksum="59346213EA700300" modified="2016-09-07" version="1">MKNIQADIKSGNFKQVYLLYGEEAYLKQQYKQNLVKALNPDGDTMNFNHYEGKGIDVKQLIDLCETMPFFAERRVVLLEDTGFFKNKCEELADYMKELPDYLYLVFAETEVDKRNRMYKAVKSCGSIAEFIRQDEKTLMRWAAGILGKAGKKITQRDMELLLTKTGTDMGNLRMEMEKLISYTEGRDVVTAEDIEEICTTQTTNRIFDMVRAVTEKNQKRALELYYDLLTLKEPPMRILFLLAKQYRQLLLAKQFAAAGLAQTEIASKLGVPGFVVRNITTCARAYTISELEQAVKDFVDAEESVKTGRLEDKLSVELLIIKYSSKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174PQB7</accession>
    <name>A0A174PQB7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADP-dependent malic enzyme</fullName>
            <ecNumber evidence="9">1.1.1.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">maeB</name>
        <name evidence="8" type="ORF">ERS852478_01360</name>
        <name evidence="9" type="ORF">ERS852523_02187</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
            <strain evidence="9 11">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.40" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000022">
        <property type="protein sequence ID" value="CUP61010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705797.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000078_gene2826"/>
    <dbReference type="EnsemblBacteria" id="CUN90359">
        <property type="protein sequence ID" value="CUN90359"/>
        <property type="gene ID" value="ERS852478_01360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP61010">
        <property type="protein sequence ID" value="CUP61010"/>
        <property type="gene ID" value="ERS852523_02187"/>
    </dbReference>
    <dbReference type="GeneID" id="66494884"/>
    <dbReference type="eggNOG" id="COG0281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="7">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="6">
        <location>
            <begin position="160"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN90359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP61010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="390" mass="41520" checksum="AFF5AC93653457F6" modified="2016-09-07" version="1">MDYAKESLKMHYDLKGKIEVVSRAKVDSKDALSLAYTPGVAQPCLEIQKDVNKSYDLTRRWNTVAVVTDGTAVLGLGDIGPEAGMPVMEGKCVLFKEFGGVDAIPLCVRSKDVDEIVKTVSLLAGSFGGINLEDISAPRCFEIEKKLKECCDIPIFHDDQHGTAVITLAGVINALKLVGKKLDEVKIVTSGAGAAGIAIIKLLMSMGLKNVIMTDRKGAIYEGREGLNPIKEEMAKITNFNKEKGTLAEVIKGADIFIGVSAPGTLTQDMVRSMAKDPIIFACANPVPEIFPDEAKAAGAAVVSTGRSDYPNQVNNVLCFPGLFRGVLDARASDVNDEMKVAAAYAIAGLVSDEELTAEYILPAAFDPRVKDAVAKAVAEAARKSGVARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174RFG7</accession>
    <name>A0A174RFG7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PD-(D/E)XK nuclease family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03801</name>
        <name evidence="2" type="ORF">ERS852523_02944</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000051">
        <property type="protein sequence ID" value="CUO75350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000035">
        <property type="protein sequence ID" value="CUP82567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_044956342.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000167.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75350">
        <property type="protein sequence ID" value="CUO75350"/>
        <property type="gene ID" value="ERS852478_03801"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP82567">
        <property type="protein sequence ID" value="CUP82567"/>
        <property type="gene ID" value="ERS852523_02944"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO75350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP82567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="318" mass="36263" checksum="B3C09EF0A6149D5F" modified="2016-09-07" version="1">MIDLAADRARYDECAKKLLTYKAVIAWILKSCTKEFSQYSVNFICDNCLKENIEISSRAVHQDHPDRSKLLDGNEQIDCLNSEANAIKDQTVYYDIRFKAYIPNTEEPVQLIINLEIQLNDTPGYPLVTRGFYYCARMISEQYGTIFTGEHYEKLQKVYSIWICPDPAKKRRNGIFRYHTVQDTVLGKPYETLGSYDLMEVVIVNLGDADKESDLEILDLLNTLFSLSTSSETKKKRLQKDFGIAMTEEFESEVQDMCNLGKALVEQGIEQGVEKKNLSLAKMMIKDKESLDKIEKYTGFSADKLKEIAASIGTNLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174RIZ4</accession>
    <name>A0A174RIZ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdopterin-guanine dinucleotide biosynthesis adapter protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Molybdopterin-guanine dinucleotide biosynthesis protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mobB</name>
        <name evidence="4" type="ORF">BWLFYP14_03277</name>
        <name evidence="2" type="ORF">ERS852478_00579</name>
        <name evidence="3" type="ORF">ERS852523_03039</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000038">
        <property type="protein sequence ID" value="CUP85414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX67000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706182.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000022_gene1764"/>
    <dbReference type="EnsemblBacteria" id="CUN59911">
        <property type="protein sequence ID" value="CUN59911"/>
        <property type="gene ID" value="ERS852478_00579"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP85414">
        <property type="protein sequence ID" value="CUP85414"/>
        <property type="gene ID" value="ERS852523_03039"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004435">
        <property type="entry name" value="MobB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03205">
        <property type="entry name" value="MobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00176">
        <property type="entry name" value="mobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobB" evidence="1">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN59911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP85414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX67000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="170" mass="19067" checksum="09E5164CDF68E323" modified="2016-09-07" version="1">MERKRIFAISGVKNSGKTTLICRLLEIFKDKGLKVAVLKHDGHDFVPDVPGTDTYCQLQSGAYGTAVFSAGKYMLVKQQPQISEKELAEFFPEADLILLEGFKYSTYPKIEIIRKGNSAESVCNPEKLMAIATNLDAEERDALSVLENVPFFELDNAECIAEFILSDYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174S2Y8</accession>
    <name>A0A174S2Y8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphate-binding protein PstS 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Phosphate-binding protein pstS</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pstS</name>
        <name evidence="7" type="synonym">pstS2</name>
        <name evidence="7" type="ORF">BWLFYP14_03514</name>
        <name evidence="3" type="ORF">ERS852478_02994</name>
        <name evidence="4" type="ORF">ERS852523_03198</name>
        <name evidence="6" type="ORF">GT712_01350</name>
        <name evidence="5" type="ORF">GT728_10035</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO49690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000042">
        <property type="protein sequence ID" value="CUP89998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000021">
        <property type="protein sequence ID" value="MZL33527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705068.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000010_gene2776"/>
    <dbReference type="EnsemblBacteria" id="CUO49690">
        <property type="protein sequence ID" value="CUO49690"/>
        <property type="gene ID" value="ERS852478_02994"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP89998">
        <property type="protein sequence ID" value="CUP89998"/>
        <property type="gene ID" value="ERS852523_03198"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014252457" evidence="1">
        <location>
            <begin position="26"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="170"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO49690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP89998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL33527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS87769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX67239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="287" mass="30104" checksum="054748B2D379A497" modified="2016-09-07" version="1">MKKKIATILTAAVIGATAFTTIVSAASGDITVVSREDGSGTRGAFVELFGIEEEKDGEKVDMTTDEASVTNSTSVMMTTVAGDENAIGYISLGSLDDTVKAVKIDGVEATVDNVSNDSYKIARPFNILTSDKESDAAKDFVNYIMSSDGQKIVEDNGYIKEAADAKAYEAADGVSGKVVVAGSSSVTPVMEKLAEGYEAVNKDVTVEVQQSDSTTGVNMAAEGTADIGMASRDLKDEEKDLGLTATVIARDGIAVIVNKDNDVDELTSDQVKAVYTGETTTWEDLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SLA6</accession>
    <name>A0A174SLA6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lon protease</fullName>
            <ecNumber evidence="5">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lon1_2</name>
        <name evidence="5" type="synonym">lon</name>
        <name evidence="12" type="ORF">ERS852478_03170</name>
        <name evidence="13" type="ORF">ERS852523_03511</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">2789STDY5834863</strain>
            <strain evidence="13 15">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 8 9">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000053">
        <property type="protein sequence ID" value="CUP98514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705987.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000094_gene760"/>
    <dbReference type="EnsemblBacteria" id="CUO55350">
        <property type="protein sequence ID" value="CUO55350"/>
        <property type="gene ID" value="ERS852478_03170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP98514">
        <property type="protein sequence ID" value="CUP98514"/>
        <property type="gene ID" value="ERS852523_03511"/>
    </dbReference>
    <dbReference type="GeneID" id="66494506"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="11">
        <location>
            <begin position="8"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="10">
        <location>
            <begin position="590"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6 8">
        <location>
            <position position="677"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6 8">
        <location>
            <position position="720"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <begin position="354"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO55350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUP98514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="770" mass="86325" checksum="16E8E5D478E71FF1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SPR3</accession>
    <name>A0A174SPR3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6 8" type="primary">rplM</name>
        <name evidence="11" type="ORF">BWLFYP14_00866</name>
        <name evidence="7" type="ORF">ERS852478_03164</name>
        <name evidence="8" type="ORF">ERS852523_03517</name>
        <name evidence="10" type="ORF">GT712_16095</name>
        <name evidence="9" type="ORF">GT728_16530</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000053">
        <property type="protein sequence ID" value="CUP98666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000051">
        <property type="protein sequence ID" value="MZL34756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000041">
        <property type="protein sequence ID" value="MZS90539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000024">
        <property type="protein sequence ID" value="VUX63388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705976.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000094_gene766"/>
    <dbReference type="EnsemblBacteria" id="CUO55167">
        <property type="protein sequence ID" value="CUO55167"/>
        <property type="gene ID" value="ERS852478_03164"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP98666">
        <property type="protein sequence ID" value="CUP98666"/>
        <property type="gene ID" value="ERS852523_03517"/>
    </dbReference>
    <dbReference type="GeneID" id="66494516"/>
    <dbReference type="eggNOG" id="COG0102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO55167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP98666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL34756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS90539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX63388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="142" mass="15987" checksum="8A92D280871AB683" modified="2016-09-07" version="1">MQTYMANPDKIERKWYVVDADGCTLGRLASGVASVLRGKNKPQFTPHVDTGDYVIIVNADKIKVTGKKLEQKIYYNHSDYVGGMRETTLKEMLAKKPERVIELAVKGMLPKGPLGRSMYTKLFVYAGPEHKHEAQKPEALTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WRX3</accession>
    <name>A0A173WRX3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Threonine/serine exporter family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_00034</name>
        <name evidence="10" type="ORF">GT712_07735</name>
        <name evidence="9" type="ORF">GT728_12795</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">BIOML-A1</strain>
            <strain evidence="10 12">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000031">
        <property type="protein sequence ID" value="MZL34055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993881.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41686">
        <property type="protein sequence ID" value="CUN41686"/>
        <property type="gene ID" value="ERS852478_00034"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="6">
        <location>
            <begin position="39"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="7">
        <location>
            <begin position="306"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN41686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL34055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS88962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="443" mass="47913" checksum="9BBFAA74A04D3439" modified="2016-09-07" version="1">MPQEVIKKNHMDVAWHEYTDENGGNVPVVDSSIAEKASIIGRVGIMFLSCGTGAWRVRSSMNTLAEALGITCTEDIGLMSIEYTCYDGENGFTQSLCLTNTGVNTLKLNRLEHFIRNFEKEGKHMSGEQLHTFLDNIEKTHGLYSPPALGLAAAIACCGFTFLLGGGPIEMFCAFVGAGIGNYLRCKLTKHHFTLFLCIVSSVSLACFAYAGLLKLGEILFGISVQHEAGYICAMLFIIPGFPFITSGIDLAKLDMRSGIERLTYALIVILVATMSAWIMALILHLKPVDFIKLSLSTEQWILFRLLASFCGVFGFSIMFNSPVRLAVAAAGIGAVANTLRLELVDLANIPPAAAAFIGALTAGLLASLLKNKVGYPRISVTVPSIVIMVPGLYLYRGFYNLGIMSLSVAASWFASAILIIAALPLGLIFARILTDKAFRYCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WSK8</accession>
    <name>A0A173WSK8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Anaerobic sulfite reductase subunit B</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Dihydrdoorotate oxidase B, electron transfer subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrK_1</name>
        <name evidence="9" type="synonym">asrB_1</name>
        <name evidence="9" type="ORF">BWLFYP14_02543</name>
        <name evidence="6" type="ORF">ERS852478_00042</name>
        <name evidence="8" type="ORF">GT712_07695</name>
        <name evidence="7" type="ORF">GT728_12835</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">BIOML-A1</strain>
            <strain evidence="8 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="4">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PyrK family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000031">
        <property type="protein sequence ID" value="MZL34063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380684.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41926">
        <property type="protein sequence ID" value="CUN41926"/>
        <property type="gene ID" value="ERS852478_00042"/>
    </dbReference>
    <dbReference type="GeneID" id="66492890"/>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN41926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL34063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS88954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="284" mass="31472" checksum="B1768DA7FB14C6AD" modified="2016-09-07" version="1">MSECTCHKNYTLDTLIPKVGVITDIRQETPDVKTFRVNAPEGGKLFEHMPGQCAMVCAPGVSEGMFSITSSPTNKEYQEFSIKKCGALTDYLHSLQVGDEITVRGPYGNHFPVEDKLKGKNLLFIAGGIGLAPLRSVINYVLDNRADYGTVDILYGSRSADDLVQLKEIQEVWMKAEGVNVYLTIDREQEGWDGHVGFVPSYLKEIGFDTNKTALVCGPPIMIKFVLAGLEELGFSREQVYTTLELRMKCGIGKCGRCNIGSKYVCKDGPVFRCDEIDELPAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WSM2</accession>
    <name>A0A173WSM2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type Fe3+-citrate transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199472.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41345">
        <property type="protein sequence ID" value="CUN41345"/>
        <property type="gene ID" value="ERS852478_00023"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008014891" evidence="1">
        <location>
            <begin position="37"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="111"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN41345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="397" mass="44407" checksum="A43D51514A97878B" modified="2016-09-07" version="1">MKMKNIIKKQQKTIFIGFMSVALFIICICTVCTAYAADKDNAKTPVDIPGLTYDHSMELSYAEEFSVDYYNDGYALITIDQEGQFLVVPEGKKAPKGLEKDITVIQQPLNNIYLVATSAMDLFRAIDGIDSIRLSGTQENGWYIQEAKDAMESGKMIYAGKYNAPDYELILNEGCGLAIESTMIHHNPEVEEKLEQFGIPVMVERSSYESHPLGRTEWMKLYAVLLGKEDVAEKAFKEQTDKLDKVLTSDDKDTGKTVAFFYINSTGAANVRKNGDYVSNMIELAGGKYVPEDTGESDNALSTMNMQMEEFYAKAKDADYIIYNSTIDGELSTIDELLAKSNLLADFKAVKDGNVWCTGKNLFQETTELGTMIEDIHTILTTDDDSLDELAYMHKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WV03</accession>
    <name>A0A173WV03_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Copper-exporting P-type ATPase A</fullName>
            <ecNumber evidence="7">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">copA_1</name>
        <name evidence="7" type="ORF">ERS852478_00067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199486.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN42756">
        <property type="protein sequence ID" value="CUN42756"/>
        <property type="gene ID" value="ERS852478_00067"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN42756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="698" mass="76390" checksum="C68C500FCC79B36B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WVK8</accession>
    <name>A0A173WVK8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199500.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43513">
        <property type="protein sequence ID" value="CUN43513"/>
        <property type="gene ID" value="ERS852478_00093"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018647">
        <property type="entry name" value="SLFN_3-like_DNA/RNA_helicase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09848">
        <property type="entry name" value="DUF2075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2075" evidence="1">
        <location>
            <begin position="214"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN43513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="474" mass="55830" checksum="39DE0B6AF7D8735E" modified="2016-09-07" version="1">MRSISIYALTRNQNKDSLSKLERQLSGREYFLKIREWELQSMKALVRQLESHMTKVCSLRFFYSYQIPKLGKEFDLLQIKDDQIINIELKSGAVSEEAIRKQLMQNRYYLSVLGRSIQSYTYISSQNRLVRLTNHDHIAEAAWTELCRSLQKESSDYQGNIDDLFQAELYLISPITEPARFLKKEYFLTSQQRDIQRQILKKLRISRFGYFCFTGLPGTGKTLLLYDIAMKLSRRQQICMIHCGNAGKEWKILHKRLQRIAFLSDNQLTENTELKHYSAVLVDEAHLLSSEKLQILLTQSEGEFPVIFSSDSEDAICPEELGVNTLKLIENLPEIQMFHLTNRIRTNAELSSFIQNMIHLTDRKTSKPYPHVSVVYANNEEETAALLEDYIHQGYEYEITAERDIKRLVIILDERYYYDQNRYLRSKHFKEGRSDVRNLFHWLNQAKEELSIIVRENTYVYETLLTLLQPDTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WXF6</accession>
    <name>A0A173WXF6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA thioester hydrolase YbgC</fullName>
            <ecNumber evidence="4 5">3.1.2.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Acyl-CoA thioesterase YbgC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">YbgC/FadM family acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybgC</name>
        <name evidence="5" type="ORF">BWLFYP14_02614</name>
        <name evidence="2" type="ORF">ERS852478_00116</name>
        <name evidence="3" type="ORF">ERS852523_01874</name>
        <name evidence="4" type="ORF">GT728_20320</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="4 5"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP51724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000099">
        <property type="protein sequence ID" value="MZL35451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703146.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000020_gene110"/>
    <dbReference type="EnsemblBacteria" id="CUN44171">
        <property type="protein sequence ID" value="CUN44171"/>
        <property type="gene ID" value="ERS852478_00116"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP51724">
        <property type="protein sequence ID" value="CUP51724"/>
        <property type="gene ID" value="ERS852523_01874"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN44171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP51724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL35451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="141" mass="16776" checksum="2171CDCF386868B0" modified="2016-09-07" version="1">MKEESEKTYTYYRKAQYHETDQMGIIHHSNYVKWMEEARIGYMSRMGFSYKKVEELGVISPVVEISVAYRKQVFFDDEIRIRVGIKQYNGISLEFNYEFFNASRNEICTTAYSRHCFLKDGKLIALKKELPELNRIITDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WXX0</accession>
    <name>A0A173WXX0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module antitoxin, RelB/DinJ family</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">RelB antitoxin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Type II toxin-antitoxin system RelB/DinJ family antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_02623</name>
        <name evidence="2" type="ORF">ERS852478_00125</name>
        <name evidence="3" type="ORF">ERS852523_01865</name>
        <name evidence="5" type="ORF">GT712_00835</name>
        <name evidence="4" type="ORF">GT728_15970</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP51497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000047">
        <property type="protein sequence ID" value="MZL34650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703163.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000020_gene100"/>
    <dbReference type="EnsemblBacteria" id="CUN44429">
        <property type="protein sequence ID" value="CUN44429"/>
        <property type="gene ID" value="ERS852478_00125"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP51497">
        <property type="protein sequence ID" value="CUP51497"/>
        <property type="gene ID" value="ERS852523_01865"/>
    </dbReference>
    <dbReference type="GeneID" id="66495899"/>
    <dbReference type="eggNOG" id="COG3077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015643">
        <property type="term" value="F:toxic substance binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044010">
        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026262">
        <property type="entry name" value="DinJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38781">
        <property type="entry name" value="PTHR38781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003108">
        <property type="entry name" value="DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN44429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP51497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS87670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="89" mass="10095" checksum="574BE1E94F4EA14F" modified="2016-09-07" version="1">MANVSIRMDDNLKKQAEDLFNDLGMNLTTAFTIFVKQAIREQGIPFEITREIPNSETISAINEVQQMKQNPSLGKAYTDVDKMMEELLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XFW3</accession>
    <name>A0A173XFW3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Catabolite control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ccpA_1</name>
        <name evidence="5" type="ORF">ERS852478_00311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577568.1">
        <property type="nucleotide sequence ID" value="NZ_AXVN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50691">
        <property type="protein sequence ID" value="CUN50691"/>
        <property type="gene ID" value="ERS852478_00311"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN50691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="339" mass="37644" checksum="B762B2086E6196EB" modified="2016-09-07" version="1">MSVTIEDIANEAKVSIATVSRVMNGTKTVSPELKKRVLDAIERNRFKPNTFAKGLATDKSNIIGVIVSDVSNAVISSTIKGINSICQKKGYTVMICESDGDSKKEKMLLERMQEHRASGVLLAGVNIDSSQVQWMLELDYPIVLFTQEAADNKTLINTVTHDNKKIIADAVEFLMANGHKRIAYISGPQNDYSSGAQRLKAFYEITKNFNLDIPDSYVVEGDFSYESGMNAMQRIYEESLVLPTAVLACCDMTAIGAIACIRKFGMKVPESLSVMGIDDTELAQYVTPSLSTIRIPYYEEGRKAARELLMLIEEEKQSTESLIYVPHKIIRRFSVKNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XHE0</accession>
    <name>A0A173XHE0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199559.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50426">
        <property type="protein sequence ID" value="CUN50426"/>
        <property type="gene ID" value="ERS852478_00303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN50426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="114" mass="12864" checksum="1EBD0E06C9260EE6" modified="2016-09-07" version="1">MSINNNPNDFLNMPAFDALRRMQEQFNNSAFVVAMRELQRTIDAVKVPTHGITAAIQAYQDSITPLTITVQNINNLYAPILEQTRMFENIYNKSMVAALQSSIPAMEIMADIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XI80</accession>
    <name>A0A173XI80_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nickel transport system permease protein nikB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nikB_1</name>
        <name evidence="7" type="ORF">ERS852478_00339</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199575.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51522">
        <property type="protein sequence ID" value="CUN51522"/>
        <property type="gene ID" value="ERS852478_00339"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN51522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="314" mass="35013" checksum="7D399DFBE3BFAC4B" modified="2016-09-07" version="1">MRKYAFRRLLQLIPILFAITFLSYGMMRIAGSDVVTQKMENTGQILSEDKLNAAREQLGLDKPFLTQYFVWLGKLLHGDMGNSYVSSLPVFDTFISKLPATLLLTVTSILLTIIISIPLGILSAVKQNTITDYLIRLCSFIGNSLPNFFVSLLLMYFLAIRLRIFPVIAKEVSLKSVAMPAITLAIAMSAKYLRQVRATVLDELSKDYVAGAKARGVKFSVTLWKSIMKASLVTIITLLMLSVGNLLGGTAIVESIFMWDGVGKMAVDAISMRDYPIIQAYVMWMAIIYVVVNLLTDLSYRFLDPRIRLGGVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XIC6</accession>
    <name>A0A173XIC6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotidyl transferase of uncharacterized function (DUF1814)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199558.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50395">
        <property type="protein sequence ID" value="CUN50395"/>
        <property type="gene ID" value="ERS852478_00302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN50395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="298" mass="34150" checksum="A8393CA0E692E0A1" modified="2016-09-07" version="1">MADIAVSVLARLKNKAKESGRSYQLCLQLFCQEEFLRRLEKSKYAENLVLKGGLFLYSLTDFDSRVTVDVDFLLRRIPNTPEQLKGILEEIIAVHTGNDFITFEIKAVAPIAVAKKYAGIGASIVTRIKNTRTPFSIDFGVGDVIVPKQEKRKIPTQLDDFVAPTINTYSIETTVAEKIDAILSLMEFSSRMKDYYDIYYLANKFDFDGKVLTEALKKTFENRGHSFTIEQFEQVMNFDNDEEMQKKWKAFVRKIDIKTDDFSTVLKTIKTFLTEPFTAAVRDKEFTEKWSAADAGWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XSH4</accession>
    <name>A0A173XSH4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anaerobic benzoate catabolism transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00396</name>
        <name evidence="3" type="ORF">ERS852523_01586</name>
        <name evidence="4" type="ORF">GT728_06350</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000013">
        <property type="protein sequence ID" value="CUP42660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000011">
        <property type="protein sequence ID" value="MZL32832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026648732.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53308">
        <property type="protein sequence ID" value="CUN53308"/>
        <property type="gene ID" value="ERS852478_00396"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP42660">
        <property type="protein sequence ID" value="CUP42660"/>
        <property type="gene ID" value="ERS852523_01586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP42660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="70" mass="8022" checksum="4C9AF86D686BDE1E" modified="2016-09-07" version="1">MPKNIAIKVARAEKDMTQKVLAEAVGVSRQTINAIEKGEYNPTIKLCRKICRVLDKSLDDLFWEDEEDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XZ15</accession>
    <name>A0A173XZ15_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeoA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199642.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56077">
        <property type="protein sequence ID" value="CUN56077"/>
        <property type="gene ID" value="ERS852478_00459"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033G73">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN56077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="70" mass="7892" checksum="A2D269276200B5AE" modified="2016-09-07" version="1">MHSLSKSSQGSTYTIKWMFGLPEVMKAMNDMDIHEGSTIRVLQKFHDSLIISSANRKIVLGNEVADRIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y4E4</accession>
    <name>A0A173Y4E4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine/hypoxanthine permease pbuG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pbuG</name>
        <name evidence="8" type="ORF">ERS852478_00552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199705.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59042">
        <property type="protein sequence ID" value="CUN59042"/>
        <property type="gene ID" value="ERS852478_00552"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026033">
        <property type="entry name" value="Azg-like_bact_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005353">
        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN59042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="458" mass="48792" checksum="4F55E0ECA415E271" modified="2016-09-07" version="1">MNLDKLFHLKENHTDVKTEVMAGITTFMTMAYILAVNPNILEASGMDRGAVFTATALSSFIATCLMAALSNYPFVLAPGMGLNAYFAYTVVLGMGYSWQQALAAVFVEGIIFILLSLTNVREAIFNAIPMNLKHAVSVGIGLFIAFIGLQNAKIVVNNDSTLVSVFSFKSSVSGGTFNTEGITVLLALIGLLITAILLVKSVKGNILWGILITWGLGIICQFIGLYKPNAAAGWYSLLPDFSNGISIPSMAPTFMKMDFSIVFTLDFVVIMFAFLFVDMFDTLGTLIGVASKADMLDKEGKLPNIKGALLSDAVGTTVGAMCGTSTVTTFVESASGVAEGGRTGLTSLVAAILFGLSLLLSPIFLAIPSFATAPALIIVGFLMLTSVTKIDFNDLTEAIPAFIAIIAMPFLYSISEGISMGVISYVIINVVTGKAKEKKISVLMYVLAVLFILKYIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y6G0</accession>
    <name>A0A173Y6G0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58736">
        <property type="protein sequence ID" value="CUN58736"/>
        <property type="gene ID" value="ERS852478_00542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN58736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="30" mass="3313" checksum="BD879F91FFEB6AFB" modified="2016-09-07" version="1">MIKKEKIVITIVLVVSCITATPVAAKKCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YC77</accession>
    <name>A0A173YC77_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ComEC family competence protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_00592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199716.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60348">
        <property type="protein sequence ID" value="CUN60348"/>
        <property type="gene ID" value="ERS852478_00592"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030420">
        <property type="term" value="P:establishment of competence for transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004797">
        <property type="entry name" value="Competence_ComEC/Rec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025405">
        <property type="entry name" value="DUF4131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13567">
        <property type="entry name" value="DUF4131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00361">
        <property type="entry name" value="ComEC_Rec2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="7">
        <location>
            <begin position="513"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN60348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="765" mass="84541" checksum="74FDAF674A4CE8B7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YDB2</accession>
    <name>A0A173YDB2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61633">
        <property type="protein sequence ID" value="CUN61633"/>
        <property type="gene ID" value="ERS852478_00628"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018674">
        <property type="entry name" value="DUF2142_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09913">
        <property type="entry name" value="DUF2142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN61633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="486" mass="56672" checksum="7AEE4751686A7DFD" modified="2016-09-07" version="1">MNVKEDMLKKKKEINEKTEIFIFVFLAFILLTTWAMTQPFNSGPDEQMRYYVADYIYKHHGALPGGDDPAVRNKVWGISYAYYPVVSYMVSALFMRISRLFADPGYSMFKIARMADVLFVTGAVYFVVKASGKLFPKEKYSREVRWLFAALAGFMPQAIFVGTYVNTDSLALLAAAMILYAWASYLREDWTWKNCILLAVGMAVCALSYYNAYGWILCSFFFFCFTVLLCREEAFSQRVRFLFSRGAVIAAVTLVLCGWWFIRNAVLYNGDFLGRKSCAECAEKYAQKDYRPSLYPTPAKLGWNWKDIILYQDPGWYHNWILTVCVSFIGTFGQMEIYMPYTVSKLYMLFFAVGIISVFFVKETFDLRKKMYVAQRKAVGNDRWKIKTKVISREWNKEGIFHLMMVFLIMIPVFLFLYYVYYSDNQPQGRYLMPALYPLMYFVTLGWNNILTKTVKNEKVRSLIYRVLTVLLVISPFACWAFLILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YDR3</accession>
    <name>A0A173YDR3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">D-alanyl-D-alanine carboxypeptidase DacB</fullName>
            <ecNumber evidence="12 13">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dacB_3</name>
        <name evidence="13" type="ORF">BWLFYP14_03227</name>
        <name evidence="12" type="ORF">ERS852478_00629</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="12 13"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX66950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61670">
        <property type="protein sequence ID" value="CUN61670"/>
        <property type="gene ID" value="ERS852478_00629"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252770" evidence="10">
        <location>
            <begin position="31"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="11">
        <location>
            <begin position="60"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN61670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX66950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="426" mass="44751" checksum="2D9CCB1D6DECEB3D" modified="2016-09-07" version="1">MMIKKKRITAALLALGLGAVTMFSQFPVSAAEETAQNTDAAAQTADPSVVVTNGIDGWPQASDISSAAAIVMETSTNTVLYSKNADQPLYPASAVKIMTCLVALENSSLDEQVTMTATGVSGVTDGGANISSQLDEVFTMEQCLYAIMVASANDIALQVAEHVGGSVDAFVQIMNTRAQELGCTNTVFTNPTGLPDENQHITAHDMALIMEAAMANDTFRTIAATTSYTLPATNVSGGERVLTNNFTMINSTSDGYYKPCIGGKEGYTEASGSTLVCEASKNNMKLVCIVLNGASGVTDDEAIALLNYGFDNFAPLTIADDDFNRLSGGTVIAPNGATEDNLTTEDTSSDGQITRQYYFGGTPVGTAILEDAEQQTNDAAVTGQKNMEAAQAYSASHTTAPYYIIGAIGAAFLLFFLFLMIKVIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YQ99</accession>
    <name>A0A173YQ99_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmI</name>
        <name evidence="10" type="ORF">BWLFYP14_01810</name>
        <name evidence="6" type="ORF">ERS852478_00698</name>
        <name evidence="7" type="ORF">ERS852523_00646</name>
        <name evidence="9" type="ORF">GT712_03200</name>
        <name evidence="8" type="ORF">GT728_03725</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP12983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706525.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64968">
        <property type="protein sequence ID" value="CUN64968"/>
        <property type="gene ID" value="ERS852478_00698"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12983">
        <property type="protein sequence ID" value="CUP12983"/>
        <property type="gene ID" value="ERS852523_00646"/>
    </dbReference>
    <dbReference type="GeneID" id="66493475"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN64968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP12983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL32325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS88119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX65046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="65" mass="7446" checksum="BD80821AD6C7C80B" modified="2016-09-07" version="1">MPKIKTCRAAAKRFKKTGTGKLVRNKAYKSHILTKKSQKRKRNLRKSTVVDATNVKSMKKALPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YTY0</accession>
    <name>A0A173YTY0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric uptake regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fur_2</name>
        <name evidence="3" type="ORF">ERS852478_00753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199788.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66897">
        <property type="protein sequence ID" value="CUN66897"/>
        <property type="gene ID" value="ERS852478_00753"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN66897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="140" mass="15850" checksum="CC9CBCBC9C693F1F" modified="2016-09-07" version="1">MAGSSYATTSRRKILEYLKNSNDHTVTAADVDEYLKKHDSEVNITTIYRYLDKLAKDGTVIKYVAEKGCQAAYQYVEPGRGCEQHLHLKCVKCGKIIHLECHFMEEISHHIEESHGFTLQCKNSILYGVCKECKGSGEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YUN2</accession>
    <name>A0A173YUN2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methionine gamma-lyase</fullName>
            <ecNumber evidence="5">4.4.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mdeA_1</name>
        <name evidence="5" type="ORF">ERS852478_00755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.11" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706464.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66966">
        <property type="protein sequence ID" value="CUN66966"/>
        <property type="gene ID" value="ERS852478_00755"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2873">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018826">
        <property type="term" value="F:methionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN66966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="437" mass="47552" checksum="C031B884D50532FB" modified="2016-09-07" version="1">MSKKIERKDRHFKFETLQLHVGQESPDPVTDARAVPIYQTSSYVFRNCDHAAARFGLADAGNIYGRLTNPTEDVFEKRIAALEGGSAALAVASGAAAITYTIENLAQQGDHIVAAKNIYGGTTNLLEHTLPAYGITTTFVDVFDLEEVENAIQDNTKAVYIETLGNPNSDVVDIEAIAKIAHAHKIPLVVDNTFATPYLVRPIEYGADIVVHSATKFIGGHGTTIGGVIVESGKFDWEASGKFASLTEPNSSYHGVSFTKACGPAAFVTKIRAILLRDTGATISPVSSFIFLQGLETLSLRVERHVENALKVVQYLNNHPQVEKVHHPSVSTDPVQQELYKKYFPNGGGSIFTFEIKGDAQKAKDFIDNLELFSLLANVADVKSLVIHPATTTHSQCTEEELLDQGIKPNTIRLSIGTENIDDIIQDLDEAFKAVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YUW3</accession>
    <name>A0A173YUW3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_01739</name>
        <name evidence="2" type="ORF">ERS852478_00782</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199793.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67951">
        <property type="protein sequence ID" value="CUN67951"/>
        <property type="gene ID" value="ERS852478_00782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN67951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX64903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="174" mass="19747" checksum="6150A3409CEB7B4B" modified="2016-09-07" version="1">MNDFLTEKNKKAGVLGKLKWVLCGFCILLSLGAIGASEKYIGEGRWGMAATEILLCLLFLYPTFREVQKALRKKKAREIACWFESYAQNTVSFEKLEQELGKGAVKKLEKFIARGYIRNIQIDREGNYIMITAPNRRVNEKIYITVTCTSCGAKNQVIKGRLSNCEYCGQRLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YW60</accession>
    <name>A0A173YW60_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellobiose phosphorylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">N,N'-diacetylchitobiose phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.280</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">chbP_1</name>
        <name evidence="4" type="ORF">BWLFYP14_01747</name>
        <name evidence="3" type="ORF">ERS852478_00774</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.280" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199792.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67693">
        <property type="protein sequence ID" value="CUN67693"/>
        <property type="gene ID" value="ERS852478_00774"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11754">
        <property type="entry name" value="GH94N_CBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009342">
        <property type="entry name" value="Carb-bd_put_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033432">
        <property type="entry name" value="GH36_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037825">
        <property type="entry name" value="GH94N_CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010383">
        <property type="entry name" value="Glyco_hydrolase_94"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17167">
        <property type="entry name" value="Glyco_hydro_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06165">
        <property type="entry name" value="Glyco_transf_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01068">
        <property type="entry name" value="CBM_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBM_X" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN67693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="811" mass="91564" checksum="FB8C0BFFE92FB0CA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z0C5</accession>
    <name>A0A173Z0C5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial SH3 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69704">
        <property type="protein sequence ID" value="CUN69704"/>
        <property type="gene ID" value="ERS852478_00834"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016517" evidence="1">
        <location>
            <begin position="33"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="275"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN69704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="328" mass="35493" checksum="C607F52D0F0955A6" modified="2016-09-07" version="1">MKKNKNLVRVSIVASLLITTSSILGQNVEVMASNPTNYKDMTEYAAYENVIADAGATSGDFGISLALYDIDQEGIRELLISHGTCLADWVNDIYTLEDGKDVSYIGNVGRQGLFYTAPDGNGMYFLYGYQGYQEITRITKSGKDIVQTLLESRELNANENYTEFANKIALLAPGDIPTHGNSYDVEVTAPDGGVNMRCGAGVEYDKVLPDMIPNGTVLTVTQEAVASNGNSWGYTNYNGTYGWIALTQVTRYQEPTEGAPIPHTRYVINCNESITLRTNPDVNAAEICQIPLGTAVATFGDAGNGFISVYYQGSSGYCLASYLSAPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z0H2</accession>
    <name>A0A173Z0H2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug export protein mepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_4</name>
        <name evidence="2" type="ORF">ERS852478_00819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199812.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69249">
        <property type="protein sequence ID" value="CUN69249"/>
        <property type="gene ID" value="ERS852478_00819"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN69249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="431" mass="46533" checksum="1D1F6F3D79CC363C" modified="2016-09-07" version="1">MLKRFTRYVTQSVAGMIGISVYVLADTFFISVYSGADGLAVLNLILPVYGLIYAIGAMIGIGSATRYAISRAKGKNTEHYFVQSVTWSILAAVPFMLIGIFIPDKALALLGADAGLIGLGRNYVRIILIATPFFMSNYTFTAFARNDGAPSIAMIGSISGSIFNIIFDYIFMFPVGLGFSGAGLATAICPIVTMSVCTIHYRSSRNHVGFHWKKPSFRHLISCCQLGVSAFVGELSSGVIAIVFNFLILGIAGNMGVAAYGVVANLSIVAFAIFNGLAQGAQPLISESYGKGQPTQVRKLLKWSLLVCLAVEALTQLIIWTSTDTLISIFNSENNVQLLNYAHTGLRLYFLGFIVAGINIVLVAYFSAVDEPKIAIVGSFLRGIVAIVICAVILAKLFGLDGIWISLLTAETVTFLTILFLAYKDRRKRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z614</accession>
    <name>A0A173Z614_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable transaldolase</fullName>
            <ecNumber evidence="9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">tal</name>
        <name evidence="12" type="synonym">fsa</name>
        <name evidence="10" type="ORF">ERS852478_00848</name>
        <name evidence="11" type="ORF">ERS852523_02497</name>
        <name evidence="12" type="ORF">GT728_00985</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">2789STDY5834863</strain>
            <strain evidence="11 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the transaldolase family. Type 3B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000026">
        <property type="protein sequence ID" value="CUP69574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706917.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000122_gene2853"/>
    <dbReference type="EnsemblBacteria" id="CUN71170">
        <property type="protein sequence ID" value="CUN71170"/>
        <property type="gene ID" value="ERS852478_00848"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP69574">
        <property type="protein sequence ID" value="CUP69574"/>
        <property type="gene ID" value="ERS852523_02497"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00494">
        <property type="entry name" value="Transaldolase_3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022999">
        <property type="entry name" value="Transaldolase_3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004731">
        <property type="entry name" value="Transaldolase_3B/F6P_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00875">
        <property type="entry name" value="fsa_talC_mipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 9 10" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN71170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP69574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL31807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="217" mass="23281" checksum="CB27242244E56097" modified="2016-09-07" version="1">MKFFIDTAKVEDIKAANDMGVICGVTTNPSLIAKEGRDFKEVIKEITSIVDGPISGEVKATTTDAEGMIKEGREIAAIHPNMVVKIPMTVEGLKAVKVLHAEGIKTNVTLIFTANQALLAARAGATYVSPFLGRLDDISTRGVDLIREIAEIFEVAGIETEIIAASVRNPIHVTDCALAGADIATVPYNVIVQMTKHPLTDAGIEKFQKDYKAVFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z8X0</accession>
    <name>A0A173Z8X0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72694">
        <property type="protein sequence ID" value="CUN72694"/>
        <property type="gene ID" value="ERS852478_00904"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBKZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045788">
        <property type="entry name" value="MobC_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19514">
        <property type="entry name" value="MobC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN72694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="133" mass="14852" checksum="84EB07A9776390AF" modified="2016-09-07" version="1">MKRYNTPHRSRVVKTRMTEEEYAEFAQRLSACNMSQAEFIRQAITGAAIRPIITVSPVNDELLAAVGKLTAEYGRIGGNLNQIARTLNEWHSPYPQLAGEVRAADTEGGLPHFFPQLRGRGFRCCLYASQSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZE70</accession>
    <name>A0A173ZE70_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-phenylhydantoinase</fullName>
            <ecNumber evidence="3">3.5.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hyuA</name>
        <name evidence="3" type="ORF">ERS852478_00965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199854.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74531">
        <property type="protein sequence ID" value="CUN74531"/>
        <property type="gene ID" value="ERS852478_00965"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN74531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="130" mass="14926" checksum="AA168A3E0E4B36D4" modified="2016-09-07" version="1">MTPPLRKQKDTDLLWDGIQTRMLYLFSEGVKKRGLSMKRFVELTSENAARFYHRYPQKGCIQPGSDADLVLITEKENTKIHVENRKSNLDYTIYEGKQLEGKIQIVIKSGQTVYKNGKLNAEKGSGKYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZGR3</accession>
    <name>A0A173ZGR3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutathione transport system permease protein gsiC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gsiC_1</name>
        <name evidence="7" type="ORF">ERS852478_00978</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199866.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74953">
        <property type="protein sequence ID" value="CUN74953"/>
        <property type="gene ID" value="ERS852478_00978"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN74953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="320" mass="35262" checksum="A5ECED5AB14E6F67" modified="2016-09-07" version="1">MFKYIVKKILMMIPMLLLISFIVYFGLQLTGIDPINFMVSPEMLSSNKENVEALRQSLGLNDPMIVQYFRWLGNCLHGDFGYSLKEGSSIASIIAVRLPYTFELAGYSLIFSAIIGVGIGIISAVRQNGIIDYVGRVLAVLGQAIPQFLVGIILIQIFCIKLGWFPSSNRVSPDATNAALDAFQHLFLPVLTLTIGMVAVLMRYARNTMLDVLNSDYIKTARSKGIPEWKVYLKHGFRNAMKPVLVILVFRIPMLVGGSVVIESVFSYPGIGLTMTNAIVSGDYPVVLVTTLIIAAAMLICSFMVDVLNALLDPRVRLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZH91</accession>
    <name>A0A173ZH91_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-N-arabinofuranosidase</fullName>
            <ecNumber evidence="5">3.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">abfA_3</name>
        <name evidence="5" type="ORF">ERS852478_00996</name>
        <name evidence="6" type="ORF">GT728_13465</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000034">
        <property type="protein sequence ID" value="MZL34185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577886.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75601">
        <property type="protein sequence ID" value="CUN75601"/>
        <property type="gene ID" value="ERS852478_00996"/>
    </dbReference>
    <dbReference type="GeneID" id="66493231"/>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="4">
        <location>
            <begin position="291"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN75601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL34185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="505" mass="57433" checksum="EF35E7070CC7786F" modified="2016-09-07" version="1">MKHIIITVNSKFKKSEIDSRIYSSFVEHMGRVVYTGIYEPNHPTADKDGFRQDVLEKVKELGITMVRYPGGNFVSNYDWKDGVGPKEERPKRLELAWRAVETNEVGINEFMRWAKKAGVEPICAVNLGTKGIENAASFLEYCNMPAGTMYSDMRVKHGVSEPYKVKLWCLGNEMDGDWQIGHKTADEYGRLAEETAKAMKLIDENIELVVCGSAKSDMPTYPEWEATVLEHVYENVDYLALHQYYGGQEMGTADFLAQSVDLDCYIDTVSGVCDYIKAKKRSEKTMYISVDEWGVWAPEGKVAHPEIEEKPWQIAPHLSEQVYTMEDSLLFASMLMSFVRHSDRVKVACQSLLTNISATIMTEKGGEVWVQPVFYPFSYMSKYARGTVMEEVYEGPSYDCSIAKNVPYVDTVTVYNEELGEIAIFAVNRAEETVSVSEELQGFVLEEIAEQLYMTSGNRKDTNLENHDKIKPYEINNAEIAGDNLNFEIEPLSWNMIRVKVKNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZNN0</accession>
    <name>A0A173ZNN0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199891.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76828">
        <property type="protein sequence ID" value="CUN76828"/>
        <property type="gene ID" value="ERS852478_01036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031617">
        <property type="entry name" value="PelG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16933">
        <property type="entry name" value="PelG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN76828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="489" mass="54605" checksum="CC8142C5B158272E" modified="2016-09-07" version="1">MAGIGFELKKLFSRRGLFASFRAYGYAGIICTGPMLLGIVLLLGVMFLCDRTGAPKQSRELLVCMITYTLLASLTVTSFLSMVVTRFIADMLYEEKNEAVLSSFWGSTGLMLIAGGILYGIFLIFSGVGLIDKFLCFELFGELIVTWNAMSYLTAIKDYRGIMLSFLAAIAVTFLSGALLLFLGISHVEALMAAVCIGYGIMLLWDVVLLYEYFPQSDISAFLFLRWADEFLPLAFTGLCINIGLFAHLVIMWAGPLGKQVKGLFYGAPSHDVPALIAFLTILITTVNFVVSVEVNFYPKYRNYYSLFNDGGTIKDIMQAGTEMLDVLNRELKYTALKQLLTTALAISMGESLLKYLPLGFNDLMYGYFRTLCVGYGIYAVANTMLLLLLYFTDYRGALAASVIFAVGTSVFTVISLFCPQVYYGFGFLAGCVLFYFIVMIRLERYTRRLPYYILSIQPVVAEDKSGVFTRIGCFMDEKLERRTNVDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A912</accession>
    <name>A0A174A912_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chb operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">chbR</name>
        <name evidence="4" type="ORF">ERS852478_01216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN84300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199967.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84300">
        <property type="protein sequence ID" value="CUN84300"/>
        <property type="gene ID" value="ERS852478_01216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="173"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN84300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="279" mass="32355" checksum="76E1FA9253FBA4B9" modified="2016-09-07" version="1">MSTHSLRFSPEDTTPQKITLLNASSSLYEGDWPSIPHSHAFTELFYVRDGQGEFLLEDKIYPISKDDLIIVNPHINHTEISRGNPPLSYFTVGVGGLSFSFNDQKEYRIFNCRKKKTDLLFYFNSLFQELDNQSEGYEKICIYMLNILILQLRRITDSPFELITAQHPSRECANIKRFLDSNYGENISLDHLSAISHLNKYYLSHEFTKYYGISPMNYLNRKRIEVCKELLENTDYGISDIAHLTGFSSQSYLSQSFRKSCGMTAGTYRKLKKKRKDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AGW5</accession>
    <name>A0A174AGW5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin reductase</fullName>
            <ecNumber evidence="2">1.8.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trxB_1</name>
        <name evidence="2" type="ORF">ERS852478_01288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.8.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200005.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87951">
        <property type="protein sequence ID" value="CUN87951"/>
        <property type="gene ID" value="ERS852478_01288"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN87951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="302" mass="31823" checksum="83BE8B2F014AA1D4" modified="2016-09-07" version="1">MEKVIIIGAGPAGISAALYAVRGNLDPLVINNGIGALEKAEKIENYYGLEHPLSGQELYDTGIAQAKALGVRILDAQVLGVGGFDTFVVKTTEGEFETQSLILATGSKRAAPKIPGVKEFEGKGVSYCAICDAFFYRGKDVAVLGNGDFAMHEAKELSNTASTVTIYTNGEEPEFTPEENVNVNTMKIQSVEGDDLVSGIRLEPDVQAEEIKAEAGQQANDFCPAEGVFIAMGTAGSTEIARQMGAELTEKGNIKVNENMETTIPGLYAAGDCTGGLLQVAKAVYEGAQAGINAGKYVRSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AHF8</accession>
    <name>A0A174AHF8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase maturation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01626</name>
        <name evidence="2" type="ORF">ERS852478_01284</name>
        <name evidence="3" type="ORF">ERS852523_00876</name>
        <name evidence="4" type="ORF">GT712_09335</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
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                <person name="Groussin M."/>
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                <person name="Avila-Pacheco J."/>
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                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
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                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
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                <person name="Venkatesh S."/>
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                <person name="Kearney S.M."/>
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                <person name="Berdy B."/>
                <person name="Zhao S."/>
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                <person name="Venkatesh S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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            <begin position="22"/>
            <end position="171"/>
        </location>
    </feature>
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            <begin position="270"/>
            <end position="325"/>
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        </source>
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            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUN96640.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZS89962.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VUX63480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="335" mass="37647" checksum="29807B6527B259E6" modified="2016-09-07" version="1">MTEFNFDTVFDETMQTHNLDTVVILGHLNPDGDAAGSVMSLAHYIHVNYPQYRVFPYLAKTLERGPKKMVVEDKIFVPFEMPDISGKQYCVIVCDNATLERMIGLEYYQNAAASIVVDHHASNEGYGDVNWTKVSEACAENVYHMLSSELLLNAAQKEAYPNAADYIYLGILHDTGGLARANQGIFQAVADLMAMGVDHGRIMKTLHSDTLDILYKRADILHGAVRAMDGRVAYVIMGQKEIAEKDITYEDIHCISTILRDCDDIELGFTMYEEEENGWRCSFRSDGKWINVNELLKPFGGGGHISAAGLKYQTDNVEELKKQILDRVAEMKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BFL2</accession>
    <name>A0A174BFL2_9FIRM</name>
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        <submittedName>
            <fullName evidence="3">Glucuronate isomerase</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">ERS852478_01567</name>
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        <name type="scientific">Blautia wexlerae</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200158.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
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    <dbReference type="EnsemblBacteria" id="CUN99527">
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        <property type="gene ID" value="ERS852478_01567"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="243"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUN99527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="401" mass="46851" checksum="5EC88CD527EAD2A5" modified="2016-09-07" version="1">MGTANQIEQELMNYISDHKIRNTHSHHLPEQAMVDFDLDKLINNTYLQWQQVTPGTTAESRNAYLEKTRYKSYFVWLQKAIGELYGISEPITAQNWDQISDQIRKAHQNPDFYMDVLKNKCKYQKVIVDTYWNPGSDNGRPELFTPAFRLDLFFLGYKKGLRNHDGVSLEENFGELPDNLQDYVEWVRKWIIQKKSEGCVALKIAMAYERSLHFEKVTREQAERVFRLKESDITQEDIRCFQDYLFWKICEIAAEVSLPLQCHTGMGQVIDTNILQLNNVIKNNPETKFVLLHCGFPWVDDLFSIVDGYPNLYPDLTWLPILSYTASKRVMHQLIEMSQIDKICWGCDTWTVEESYASLLAFRFSLCSVLREKIEDGYLSVNNAKDIIDKILFDNAGKIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BH52</accession>
    <name>A0A174BH52_9FIRM</name>
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        <submittedName>
            <fullName evidence="9">Chromosome segregation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852478_01566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99499">
        <property type="protein sequence ID" value="CUN99499"/>
        <property type="gene ID" value="ERS852478_01566"/>
    </dbReference>
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    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
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        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
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        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="732"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="774"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="827"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="900"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1126"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1185"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1226"/>
            <end position="1244"/>
        </location>
    </feature>
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        <location>
            <begin position="757"/>
            <end position="852"/>
        </location>
    </feature>
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        <location>
            <begin position="568"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="606"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN99499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1261" mass="140656" checksum="1A0907ECC8DFF29F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BIL7</accession>
    <name>A0A174BIL7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01564</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200155.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99438">
        <property type="protein sequence ID" value="CUN99438"/>
        <property type="gene ID" value="ERS852478_01564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FN3_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018467" evidence="3">
        <location>
            <begin position="25"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN99438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="555" mass="62694" checksum="189636F13D132AA0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BMX8</accession>
    <name>A0A174BMX8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage II sporulation protein AC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sigF_2</name>
        <name evidence="3" type="ORF">ERS852478_01643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02104">
        <property type="protein sequence ID" value="CUO02104"/>
        <property type="gene ID" value="ERS852478_01643"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO02104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="147" mass="16887" checksum="084AE08559E2A22A" modified="2016-09-07" version="1">MLKVSRNLKENCARIYSAREALEKELGREPILEEVAKATELSVDEVVMSMESGAEVESLHKIIYQGDGNDISLMDRLQEKENGQDAALNRIFLDEILKKLDARERQLIGMRYFKDMTQTEIAAEMGISQVQVSRMEKRILKELKKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BPH2</accession>
    <name>A0A174BPH2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Manganese transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mntR_4</name>
        <name evidence="6" type="ORF">ERS852478_01621</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_024720760.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01436">
        <property type="protein sequence ID" value="CUO01436"/>
        <property type="gene ID" value="ERS852478_01621"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO01436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="126" mass="14145" checksum="E00D33ECFA398FDA" modified="2016-09-07" version="1">MKIYASGEDYLEAVLVLQKEKGMVRSVDLARHMGFSKPSISHAVGVLKNGGFLTVDEDGYLHLTEDGREVAEKIYERHQFFTEQLVAVGVDRETAERDACRIEHAISEETFQKLKASVEKQSNDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C2Q3</accession>
    <name>A0A174C2Q3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CysJI operon transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysL_3</name>
        <name evidence="3" type="ORF">ERS852478_01743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578274.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06170">
        <property type="protein sequence ID" value="CUO06170"/>
        <property type="gene ID" value="ERS852478_01743"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO06170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="298" mass="34233" checksum="D79D6A316C3E34D2" modified="2016-09-07" version="1">MTLRYMKIFVSVYEHNSITKAADVLHLAQPSVSLAIKEMEEYYGTRFFERIGRHISPTGAGNELYRYALHIIELFDEMEQKIKDWDHCGTLRIGASITIGTHILPLMLKQYQEIYPMLKITVIIKQSAAIEQLVLENKIDIALIENQPEYADIMAIPFMTDHLCAIVPVTHPLADKKWVTLEEVSAYPFLMREKGSAGREILDAGFELKNITVHPVWESTSTQAIVKAVSVGLGVAVLPYLLVKKDMEENHVCLLPFKKPLKRNLNVIYYKRKYFTEQMKSFIDLCRKYGKDYESAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C3B0</accession>
    <name>A0A174C3B0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock protein J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dnaJ_2</name>
        <name evidence="3" type="ORF">ERS852478_01797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200268.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07892">
        <property type="protein sequence ID" value="CUO07892"/>
        <property type="gene ID" value="ERS852478_01797"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO07892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="368" mass="38950" checksum="92BC0A56960AF3E0" modified="2016-09-07" version="1">MILKRDYYEVLGVNKNADAATIKKAYRKLAKKYHPDSNEGNASAAEHFKEVNEAYDVLSDEKKRKLYDQFGHAAFEEGAGNYGNAQGSPFGSGFGGAQGNPFGGGFHGSYSDGNGYHEYHFENGEDMDDILKNIFGGGFKKSKSSGGFGSSGFGGSGFHGSGFGGFGSNGTGGFGGSYSSKGEDLHAEVTVSFDEAAFGGKKVIRLQSSNGGVQNYEVNIPAGIESGKSIRLKGKGYPGVGGGEAGDLLLKVNVQDKPGYKREGRDIYTTVNIPFTTAVFGGEAKVHTIYGDVLCNIKPGTQSGTKIRLRGKGIVAMNNPSVHGDEYATVQIEVPTNLTPEARRKLKEFEQECNGSRRSRGFGSGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C3B9</accession>
    <name>A0A174C3B9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative colanic biosynthesis UDP-glucose lipid carrier transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">wcaJ_2</name>
        <name evidence="9" type="ORF">ERS852478_01780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057950.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07317">
        <property type="protein sequence ID" value="CUO07317"/>
        <property type="gene ID" value="ERS852478_01780"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="255"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO07317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="466" mass="53938" checksum="7637471CF86FA61B" modified="2016-09-07" version="1">MSKREDYKRFIVFCLASLVVLAQAAVFAWVWYSVYRGQIDEPFWRKGNWVLIAIYGLMFALFAKLYGGLKVGYLKRIDVFYSLTLALLCTNVVEYLEITLINRWFLSVWPMIEMTGIQLVLIIIWIFGSRYIYSGLYRARRLLVIYGDRDPGDDLIHKMNSRKDKYDISGKVHISVGEEKIHQMMQDYDGVIIWDLHSTERNRYLKYCFAHSVRCYVSPKISDIILMGSERIHLFDTPLLVSRNMGLAVDQRAAKRVMDILISGIGIIITSPIMLIIATAVKAYDRGPVFYFQDRLTLGGKPFKICKFRSMCVDSEKNGARLASKHDSRITPVGHVLRNLHLDELPQLFNVFKGDMSLVGPRPERESIMLEYEKELPEFYYRLKVKAGLTGYAQVYGKYNTTPYDKLKLDLFYIENYSFLLDIKLIFMTVKIFFQKEVSEGVDDRQVNALKDSGKNAGVSENKTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C7T5</accession>
    <name>A0A174C7T5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable Hsp20 family chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200270.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07955">
        <property type="protein sequence ID" value="CUO07955"/>
        <property type="gene ID" value="ERS852478_01799"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="37"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO07955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="155" mass="17851" checksum="A31EC715F14298B0" modified="2016-09-07" version="1">MLMPSIFGENLFDDFFGDFPFYYDDRAMKDTEKKLYGRRASHIMKTDIKETDKGYELVVDLPGFTKDEVKADLENGYLTISAEKGLDKDEQEKKTGHYIRKERYAGACSRSFYVGKEVEKEDIKAEFKHGILTLFVPKKEAKPAVEQKKTIAIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CC66</accession>
    <name>A0A174CC66_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative adenylyl cyclase CyaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200363.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10377">
        <property type="protein sequence ID" value="CUO10377"/>
        <property type="gene ID" value="ERS852478_01852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07890">
        <property type="entry name" value="CYTH-like_AC_IV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008173">
        <property type="entry name" value="Adenylyl_cyclase_CyaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21028">
        <property type="entry name" value="PTHR21028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00318">
        <property type="entry name" value="cyaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="1">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO10377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="190" mass="21663" checksum="38E53201C6E7FC2B" modified="2016-09-07" version="1">MSIEVEIKLKIKNKKQVIDSLKTIGFLEGRYVVETDTYYTSSHHDFTARGEALRIRKVEDPKSGKETCLITYKGAKLDQVSMTRQELETEVGDGETVRKILEIIGFCPVSPVEKQRLYLRKDNMTACLDEVKGLGNYLELEILTDAEEERTKALKQIENVLEILGYSMKDTTRTSYLSMLKKKDKDGSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CCI6</accession>
    <name>A0A174CCI6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transposase DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_01857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200371.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10517">
        <property type="protein sequence ID" value="CUO10517"/>
        <property type="gene ID" value="ERS852478_01857"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="5">
        <location>
            <begin position="434"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO10517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="543" mass="62109" checksum="A0EE688B1E1202EB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CCY5</accession>
    <name>A0A174CCY5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_01871</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200394.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10943">
        <property type="protein sequence ID" value="CUO10943"/>
        <property type="gene ID" value="ERS852478_01871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO10943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="106" mass="11743" checksum="43EBD72798233348" modified="2016-09-07" version="1">MTELKITAANFENEVLHSDKPVLLDFYADWCGPCKMLSPILHELAEEKSGALKVGKINVDEQMELAMRFQVSSIPMLVVFKDGKAVAKSVGYRPKSEIAAMVESAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CIN0</accession>
    <name>A0A174CIN0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Benzoyl-CoA reductase subunit B</fullName>
            <ecNumber evidence="3">1.3.7.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bcrB</name>
        <name evidence="3" type="ORF">ERS852478_01936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.3.7.8" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200452.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12994">
        <property type="protein sequence ID" value="CUO12994"/>
        <property type="gene ID" value="ERS852478_01936"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018522">
        <property type="term" value="F:benzoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO12994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="423" mass="47853" checksum="A8E240F86926819C" modified="2016-09-07" version="1">MQIIETFGHYVENLTNTKPDSARWLLKTGWEAQNLKFRYMQDKRLMPADRHLANLMMDTMLRPLQKPEDSVIVSIFTPCEMMQEVGLHPYNVEGFSCYLSASKAERAFLQQAENQGIAETLCSYHKTFLGAAQKGLLPKPKCIVYTNLTCDANLLTFRTLADFYQVPVFAIDVPWNQTKENVQYVADQLKDLKVFLEKNTGKTISEDRLKERLACSKRTLENYKKYQQLRADRYVPSDLVTPLYAGMTNNILLGTAEEEKYTQMLLENIKKAPAAKGKHIYWMHTIPFWSDAVRQELCFSEKAQIVGCELAETCEPDFDPEKPFEAMAERMVYHSLNGSALRRIEAGIRHAKQAGADGAVWFGHWGCKHTLGAAQLAKKKFEEAGLPLLILDGDGCDRSHGGEGQTSTRLGAFLEMLGGAENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CMT0</accession>
    <name>A0A174CMT0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AraC family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Arabinose operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">araC_3</name>
        <name evidence="4" type="synonym">araC_1</name>
        <name evidence="4" type="ORF">BWLFYP14_02189</name>
        <name evidence="2" type="ORF">ERS852478_01944</name>
        <name evidence="3" type="ORF">GT728_10630</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000023">
        <property type="protein sequence ID" value="MZL33640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993980.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13230">
        <property type="protein sequence ID" value="CUO13230"/>
        <property type="gene ID" value="ERS852478_01944"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="185"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO13230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="287" mass="34215" checksum="28839DE50AE82300" modified="2016-09-07" version="1">MYMNTGYLNHSHMDFKDKSRPLVVGSCGTYRLSSHPKLPTYRPKGRLDYQIIYITAGCGHFHFDNVDNETIVPAGNIVLYRPKELQKYEYYGKDKTEVYWIHFTGNNVKNILRQYGFPDKERVFQVGTSMEYEQIFKRIIIELQRCQDNYEEMLVLLLRHLLIIFHRELTREHISKNEYLDHEMDNAVTFFSENYNQNISIDDYAASRGMSVSWFIRNFKKYTGSTPMQFIVGIRINNAQMLLETTTYSINEISKIVGYDNQLYFSRLFHKLKGYSPREYRKIRNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CQ09</accession>
    <name>A0A174CQ09_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_02172</name>
        <name evidence="1" type="ORF">ERS852478_01961</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13775">
        <property type="protein sequence ID" value="CUO13775"/>
        <property type="gene ID" value="ERS852478_01961"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO13775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX65807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="97" mass="11602" checksum="8D7ED4A83BB2038B" modified="2016-09-07" version="1">MAGFPYEIYYFSRNMEHVLHDRAENLTDDEKEDLAFDIADQYTDQLEKFLEYLHDDGFYVCGTYKDTWEFIMDGNNSLNRYCSYCNVAVFFEQLEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CQJ5</accession>
    <name>A0A174CQJ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">recO</name>
        <name evidence="9" type="ORF">ERS852478_02003</name>
        <name evidence="10" type="ORF">ERS852523_00079</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
            <strain evidence="10 12">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the RecO family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUO96241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2245"/>
    <dbReference type="EnsemblBacteria" id="CUO15841">
        <property type="protein sequence ID" value="CUO15841"/>
        <property type="gene ID" value="ERS852478_02003"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96241">
        <property type="protein sequence ID" value="CUO96241"/>
        <property type="gene ID" value="ERS852523_00079"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO15841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO96241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="250" mass="28251" checksum="E35F1B97ACFEE56B" modified="2016-09-07" version="1">MSDLITVQGVVLSAMPVGEYDKRIVLLTRERGKISAFAKGARRPNSQFLAAANPFVFGTFALYEGRSSYNLNQVSISHHFVELAGEQPGIYYGYYFLELADYFGQEGIDEKESMNLLYVTVKALLNPNIDNRLVRCIFELRMMAAQGLCPSLFHCVCCERQPVEGEELFFSQQNHGILDKACLGHVNDAKRISAPALYAMQYIVTASLGKLYTFTVTEEVLHELERHIHTYIAANTEKRFKSLEILEIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CVR5</accession>
    <name>A0A174CVR5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Internalin-J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">inlJ_2</name>
        <name evidence="4" type="ORF">ERS852478_02013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200481.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16199">
        <property type="protein sequence ID" value="CUO16199"/>
        <property type="gene ID" value="ERS852478_02013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040528">
        <property type="entry name" value="Lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18560">
        <property type="entry name" value="Lectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019533" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="2">
        <location>
            <begin position="961"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="domain" description="Lectin_like" evidence="3">
        <location>
            <begin position="1144"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="2">
        <location>
            <begin position="1367"/>
            <end position="1403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO16199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1407" mass="156591" checksum="400E2F2D6BD4A3CC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CWL1</accession>
    <name>A0A174CWL1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted AAA-ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200523.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17594">
        <property type="protein sequence ID" value="CUO17594"/>
        <property type="gene ID" value="ERS852478_02058"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018631">
        <property type="entry name" value="AAA-ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012547">
        <property type="entry name" value="PDDEXK_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09820">
        <property type="entry name" value="AAA-ATPase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08011">
        <property type="entry name" value="PDDEXK_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA-ATPase_like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO17594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="568" mass="66033" checksum="688AAE31E5F2E35A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CYA3</accession>
    <name>A0A174CYA3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor SigF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02366</name>
        <name evidence="2" type="ORF">ERS852478_02078</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO18254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18254">
        <property type="protein sequence ID" value="CUO18254"/>
        <property type="gene ID" value="ERS852478_02078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4" evidence="1">
        <location>
            <begin position="102"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO18254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="157" mass="18673" checksum="70C57520E9F60402" modified="2016-09-07" version="1">MYIEHPYFYEGKYYANIDGEMIEVTKEVAYAMNNFYRSSKAKKVEIKNELGEVVDKMLREVPYSGQSIDGEVFMIEDFPDLNCDVEHCVLTKMEQQDIHKVINQLNSEERMIIYGIFFENKTQTQMAEIMGISRQMLSYKLKSTLNKMREMYMNKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D0Y1</accession>
    <name>A0A174D0Y1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diaminopimelate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lysA_2</name>
        <name evidence="3" type="ORF">ERS852478_02086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200539.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19083">
        <property type="protein sequence ID" value="CUO19083"/>
        <property type="gene ID" value="ERS852478_02086"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="1">
        <location>
            <begin position="260"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO19083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="399" mass="45155" checksum="6FB850631FA64C14" modified="2016-09-07" version="1">MSSYGFIKELIEKEHTPTPAYVFDLDKMKEFVKKVQSCLGESAQLCYAMKANPFLTGPMMDVVPTFEVCSPGEFRICERVGVPMERIVLSGVYKNPEDMEYVLSTYGGKGVYTVESLQHLQILNETAVRLGMKITVLIRVTSGNQFGVDEADIRKIISDRTDYPGVEIEGLQFYSGTQKKDLSQMKTELEHLDEFIGELKSESGFEAQVLEYGPGFFVPYFKKDKSEDVENILSEFRALLESLNFRGKVVLEMGRFLAAACGYYVTSIVDMKVNKEQPYVIMDGGINHLNYYGQAMAMKQPYCTQLDTEGNEKTGGEEESWNLCGALCTVSDVVVKRFPLHKPQLHDILVFERVGAYSVTEGIYLFLSRPLPRIYFWTEGEGLRMVRDGVHTDLLNSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D3R1</accession>
    <name>A0A174D3R1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hssR</name>
        <name evidence="10" type="ORF">BWLFYP14_02816</name>
        <name evidence="9" type="ORF">ERS852478_02125</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20291">
        <property type="protein sequence ID" value="CUO20291"/>
        <property type="gene ID" value="ERS852478_02125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO20291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX66442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="223" mass="25439" checksum="75C5AB3AD8E039D4" modified="2016-09-07" version="1">MFQILIVEDDKELSQLFQKVLEKNGYQVKSASDGAQALEVLDKEYIDLIISDIMMPVMDGYELVSELRSAGYQIPVLMITAKGSFDDMRQGFLSGSDDYMVKPVNVNEMVLRVGALLRRAQILNEHKIVIGSTEFDYDAMTVTTDKESLVLPKKEFLLLYKLAASPGRTFTKQQLMDEVWGYETEADPHTIEVHIGRIRERFKDNPDFEIVTMRGIGYKVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D6S2</accession>
    <name>A0A174D6S2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005334884.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20927">
        <property type="protein sequence ID" value="CUO20927"/>
        <property type="gene ID" value="ERS852478_02145"/>
    </dbReference>
    <dbReference type="GeneID" id="42423193"/>
    <dbReference type="GeneID" id="64114160"/>
    <dbReference type="GeneID" id="66578993"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO20927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="66" mass="7744" checksum="185A49556946D584" modified="2016-09-07" version="1">MTVYMDLENLLKEKNISKNKVCEACNLQRTQLNNYCKNKVTRIDFSILAKLCEYLDCTPNDILKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DFV0</accession>
    <name>A0A174DFV0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thermophilic metalloprotease (M29)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24057">
        <property type="protein sequence ID" value="CUO24057"/>
        <property type="gene ID" value="ERS852478_02228"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO24057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="677" mass="77892" checksum="8A87A02A804014EB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DIC4</accession>
    <name>A0A174DIC4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SseB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO23895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705480.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23895">
        <property type="protein sequence ID" value="CUO23895"/>
        <property type="gene ID" value="ERS852478_02223"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030Q9J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="154"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO23895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="256" mass="29605" checksum="BC3984FE7F556B52" modified="2016-09-07" version="1">MGISKEEAIKELQTREEIFVAYSQATKLPYVKCDEETFNDQAWIFSTEEGIKEFGKKMLEEKVLLMGMKFTKKDYPRLYGTFYAIGVNTVVWVDGEDKIEIDLPDIAKQADMSKIEPAKRPLLNPTLELSGIYFMQELRRPVEKDQHGNLRELEEELIVNLKKSEYLVAMNVDPEDPKKINIPYLKNKKEEILQPVFTDVMELEKFTKGQKLRIAKVPFAKLPELLIDKAMAYAVNPLGFNLVLNREQLNKIIGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DKZ7</accession>
    <name>A0A174DKZ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Replication initiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmid replication initiation factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200659.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24805">
        <property type="protein sequence ID" value="CUO24805"/>
        <property type="gene ID" value="ERS852478_02255"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2946">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003916">
        <property type="term" value="F:DNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003491">
        <property type="entry name" value="Rep_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040819">
        <property type="entry name" value="Rol_Rep_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02486">
        <property type="entry name" value="Rep_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18106">
        <property type="entry name" value="Rol_Rep_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO24805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="398" mass="47263" checksum="2FC2A91185D4F9A0" modified="2016-09-07" version="1">MVLNEEQWIKELREKRIAYSISQGRLAVASGITREYLNKIESGKMKPSKELLENLHKELARFNPEAPLTMLFDYVKIRFPTLDIQHIIKDILKLNINYMLHEDYGRYSYTEHYSLGDIFIYTSADEEKGVLLELKGRGCRQFESYLLAQQRSWYDFLMDALVDGGVMKRIDLAINDHTGILDIPELAEKCRKREYIGKSRSYKFYQSGELIKHREDDREYMGRTLYLGSLKSDVYFCIYEKDYEQYVKLGTPLEEADIINRFEIRLRNERAYYAVRDLLTYYDAEQTAFSIINQYVRFVDEEPDKQKNDWKLNDRWAWFIGDNRQSLKLTTKPEPYTLDRTLRWVQRQVAPTLKMLKKIDKGNGTDYMETIEQQAKLTKKHEMIIKQQTTPAKDLVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DLE5</accession>
    <name>A0A174DLE5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_02304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380183.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26381">
        <property type="protein sequence ID" value="CUO26381"/>
        <property type="gene ID" value="ERS852478_02304"/>
    </dbReference>
    <dbReference type="GeneID" id="66494421"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="437"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO26381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="539" mass="61948" checksum="5E1E181F6D78AB40" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DX46</accession>
    <name>A0A174DX46_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ilvA</name>
        <name evidence="10" type="ORF">BWLFYP14_00171</name>
        <name evidence="7" type="ORF">ERS852478_02364</name>
        <name evidence="8" type="ORF">ERS852523_02035</name>
        <name evidence="9" type="ORF">GT712_04660</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
            <strain evidence="8 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000019">
        <property type="protein sequence ID" value="CUP56244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704690.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1093"/>
    <dbReference type="EnsemblBacteria" id="CUO28839">
        <property type="protein sequence ID" value="CUO28839"/>
        <property type="gene ID" value="ERS852478_02364"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP56244">
        <property type="protein sequence ID" value="CUP56244"/>
        <property type="gene ID" value="ERS852523_02035"/>
    </dbReference>
    <dbReference type="GeneID" id="66494252"/>
    <dbReference type="eggNOG" id="COG1171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="325"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO28839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP56244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS88403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX66618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="403" mass="43630" checksum="05D001A59024E076" modified="2016-09-07" version="1">MLTLESFEQASEIVKQVTQETKLIKSSYFSELTGNKVYLKPENMQRTGAYKVRGAYYKISTLSDEERNKGLITASAGNHAQGVAYAAHKYGVKAVIVMPTTTPLIKVERTKSYGAEVILHGDVYDEACAHALELAEKEGYTFIHPFDDPAVATGQGTIAMEIVQELPLVDYILVPIGGGGLATGVSTLAKLLNPHIKVIGVEPAGAACMKASLKKGEVVTLPHVNTIADGTAVQTPGKKIFPYIQKNLDDIITIEDDELIVAFLDMVENHKMIVENSGLLTVAALRHLDVKGKKIVSILSGGNMDVITMSSVVQHGLIQRDRIFTVSVLIPDKPGELVRVASVIARAQGNVIKLDHNQFVSTNRNAAVELKITLEAFGTDHKNEIVKALEDAGCRPKVIRPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E6U1</accession>
    <name>A0A174E6U1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_02165</name>
        <name evidence="1" type="ORF">ERS852478_02456</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32169">
        <property type="protein sequence ID" value="CUO32169"/>
        <property type="gene ID" value="ERS852478_02456"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO32169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX65800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="62" mass="7165" checksum="5936AA6600AD68C7" modified="2016-09-07" version="1">MKKTYQRLPESELDIMLVLWNNTPPMNRMEIVAAGEGDEESRVLYNNGDGTWIDENGNLHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E7Q5</accession>
    <name>A0A174E7Q5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02147</name>
        <name evidence="4" type="ORF">ERS852478_02473</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200758.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32598">
        <property type="protein sequence ID" value="CUO32598"/>
        <property type="gene ID" value="ERS852478_02473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO32598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="442" mass="51411" checksum="20481D800BB1A408" modified="2016-09-07" version="1">MRIVSSYGVELRKQNIPICQTLDIYRSAVSCLIGIYAQTWDELAVITEPKKRFNTAEHLVHTTKKNQARFDFDLRFPKMPSYLRRAAIQHALGSVSSYKTRLGLWKKTDQKGGRPKLVCDNHAIPVFYRDVMYREDTEEKDRVCLKLYDGHDWKWFRVSLSHTDMEYLRKNWAGKKAAAPVLEKRHRKYFLRFSYTEEVPLTKTPAKERIICSVDLGLNTDAVCTIMRSDGTVLGRRFIDFPSEKDRMYSVLGRISRFQREHGSAQVKSRWAYAKRLNTELGRKIAGAVTGYAEENHADVIVFEYLETKGKISGRKKQKLHLWRKRDIQKRCEHQAHRRGIRISRICAWNTSRLAYDGSGTVVRDPGNHSLCTFQNGKRYNCDLSASYNIGARYFIRELLKPLPVTERSLLEAKVPSVKRRISCVYADLRELFSEMEILRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EBK3</accession>
    <name>A0A174EBK3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">argS</name>
        <name evidence="13" type="ORF">ERS852478_02504</name>
        <name evidence="15" type="ORF">GT712_02335</name>
        <name evidence="14" type="ORF">GT728_13250</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="14 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">BIOML-A1</strain>
            <strain evidence="15 17">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000033">
        <property type="protein sequence ID" value="MZL34142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058420.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33370">
        <property type="protein sequence ID" value="CUO33370"/>
        <property type="gene ID" value="ERS852478_02504"/>
    </dbReference>
    <dbReference type="GeneID" id="66495255"/>
    <dbReference type="eggNOG" id="COG0018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="470"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO33370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZL34142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZS87960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="588" mass="66036" checksum="782158EE7C099F29" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EIM9</accession>
    <name>A0A174EIM9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">G3P acyltransferase</fullName>
            <shortName evidence="10">GPAT</shortName>
            <ecNumber evidence="10">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="10">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">plsY</name>
        <name evidence="11" type="ORF">ERS852478_02591</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PlsY family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36376">
        <property type="protein sequence ID" value="CUO36376"/>
        <property type="gene ID" value="ERS852478_02591"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00023">
        <property type="entry name" value="TIGR00023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO36376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="214" mass="23641" checksum="7CF5B39D40816910" modified="2016-09-07" version="1">MERLICIAIGYACGLFQTAYILGKIYHIDIRKQGSGNLGSTNVLRTLGKKAGALNLLCDCLKCIAAILIVRAIFGNSYGDILPLLSLYAAAGCILGHNFPFYLNFKGGKGVAASVGLVIAFDWRIFVICAIVFFGLFFLTHYVSLCSVSAYLTAFISMIVFGQMGSYHMDFSHMIELYTVMGLLTVLAFYRHKKNIKRLLDGTESKIYLSKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EMY0</accession>
    <name>A0A174EMY0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhamnulose-1-phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rhaD</name>
        <name evidence="6" type="ORF">BWLFYP14_00918</name>
        <name evidence="5" type="ORF">ERS852478_02655</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-rhamnulose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:19689"/>
            <dbReference type="ChEBI" id="CHEBI:18041"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:58313"/>
            <dbReference type="EC" id="4.1.2.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldolase class II family. RhaD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.19" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060114.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38597">
        <property type="protein sequence ID" value="CUO38597"/>
        <property type="gene ID" value="ERS852478_02655"/>
    </dbReference>
    <dbReference type="GeneID" id="66492683"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00541">
        <property type="reaction ID" value="UER00603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008994">
        <property type="term" value="F:rhamnulose-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00770">
        <property type="entry name" value="RhaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013447">
        <property type="entry name" value="Rhamnulose-1-P_Aldolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0684">Rhamnose metabolism</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aldolase_II" evidence="4">
        <location>
            <begin position="10"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO38597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX63440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="276" mass="31262" checksum="DBD8C83CC7370AF5" modified="2016-09-07" version="1">MKILESKFVQGFIKMANDGYLQGWHERNGGNLSYRLKPEEVEMIRPRLNATGEWIPIGVEVPGLAGEFFLVTGSGKYFRNIIVDPEVCLAIIELDETGTNYRIRWGLVEGGRPTSELPTHLMNHEVKKKLTNGKHRVIYHAHTTNTIALTFVLPLDDKIFTRELWESATECPVVFPDGVGVVGWMVPGGREIAIKTAELMKKYDVVIWAHHGMFCSGEDFDLTFGLLHTVEKSAEILVKILSMTPNKLQTITPDNFRSLAKDFKVSLPEEFLYEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EVJ4</accession>
    <name>A0A174EVJ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphinothricin N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.183</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pat</name>
        <name evidence="2" type="ORF">ERS852478_02757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.183" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200901.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41794">
        <property type="protein sequence ID" value="CUO41794"/>
        <property type="gene ID" value="ERS852478_02757"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102971">
        <property type="term" value="F:phosphinothricin N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO41794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="187" mass="21674" checksum="A3C3A13B64003358" modified="2016-09-07" version="1">MDNKIIIRTASAADAPALLKIYRPYVENTAITFEYDVPSTEEFASRIEHTLKKYPYLVAEEKGALLGYAYAGPFHERPAYDWAVETSIYVDQSLKHRGIGRRLHDALETALREQGILNMNACIAYPPKEDEHLDKNSVEFHTHMGYRLVGEFHKCGYKFNHWYNMVWMEKLIGEHLTVQEPPKFPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F2X7</accession>
    <name>A0A174F2X7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase domain (DUF772)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_00065</name>
        <name evidence="2" type="ORF">ERS852478_02799</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000023">
        <property type="protein sequence ID" value="VUX63357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200932.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43288">
        <property type="protein sequence ID" value="CUO43288"/>
        <property type="gene ID" value="ERS852478_02799"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF772" evidence="1">
        <location>
            <begin position="55"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO43288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX63357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="490" mass="56045" checksum="D2DF668F81FAB430" modified="2016-09-07" version="1">MIPYKQLSLADIFSDCHEKFENDKPAFLSLLETHIDIDELIPISFRNHFYASTGRTRKYPLQAFLWALIIQRIFSIPTDQLLLTFLAYSKSLREFCGFTKVPDASKITRFKQDFLDDLQLVFDNLVDVTEPICQAIDSAKADMTIFDSSGIEAFVTENNPKYANRIIKQLKAYAKAQGFDKSYDPYKAAYGSMPSHASANPEIKQLYINGHFCYVFKFGIVTNGLGIIRHISFYNKNFMASHPDIVVEKKSDSPDEDKCVHDSKLLIPTLKDFFSKHPLINPKTFLGDAAFDTAQLYKSLLTGDTFGNDKHFSKAYIPLNARSGLENLDYSINEDGIPCCPHDPSLQMKYEGTSKLHSGVTRYKFVCPRMKWIYDKSTQKSHRHCFCDNPCTSSKCGRMVYIYPEKDLRAYPGTIRGTEKWDDTYKIRTVVERDINHIKDNLCLAGRRTQNERTLHADLILAGITQLITVVLADKINHHEYIRSIKPLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F3B3</accession>
    <name>A0A174F3B3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trxA_4</name>
        <name evidence="4" type="ORF">ERS852478_02775</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059712.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42665">
        <property type="protein sequence ID" value="CUO42665"/>
        <property type="gene ID" value="ERS852478_02775"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO42665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="105" mass="11846" checksum="85613B31FD3AFE7D" modified="2016-09-07" version="1">MAVRVSNADFEEKVLKEKLTVLVDFYSDSCVACKKLAPVLGNAEDDYEDKIKIYKVNTNFDVELAEQYEVQANPTLILFKDGQAKDRKTGALKQAELNSWIEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F985</accession>
    <name>A0A174F985_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_00838</name>
        <name evidence="2" type="ORF">ERS852478_02871</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000022">
        <property type="protein sequence ID" value="VUX63261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379820.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000067.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45498">
        <property type="protein sequence ID" value="CUO45498"/>
        <property type="gene ID" value="ERS852478_02871"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZUIM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025699">
        <property type="entry name" value="ABC2_memb-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13346">
        <property type="entry name" value="ABC2_membrane_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
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        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO45498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX63261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="216" mass="23512" checksum="949F4969B853B56A" modified="2016-09-07" version="1">MKGLFVKDIELMKQQKQFFILVVVMGVILNLAGSGSVSFATGYFTIVTAIFAITTISYDEFDNGLAFLMTLPVTRKQYVAEKYLLGAGLTAVAWGIATITGVICKGVAELQGCLSETIIGSLIYIPLALLMLAVSLPLVIHFGAEKGRYIAMVMWAIIFAVVYILIKTMGLSADAVDAWLNGLNRGMVLAGVVLFTVIVYMGSFWIGVRLMEKKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FA32</accession>
    <name>A0A174FA32_9FIRM</name>
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        <submittedName>
            <fullName evidence="2">AlwI family type II restriction endonuclease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">AlwI restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_03417</name>
        <name evidence="1" type="ORF">ERS852478_02895</name>
        <name evidence="2" type="ORF">GT712_18015</name>
    </gene>
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        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CUO46427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705141.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46427">
        <property type="protein sequence ID" value="CUO46427"/>
        <property type="gene ID" value="ERS852478_02895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018573">
        <property type="entry name" value="Restrct_endonuc_II_AlwI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09491">
        <property type="entry name" value="RE_AlwI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO46427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS90892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX67140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="596" mass="69622" checksum="92857691762967E5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FC21</accession>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200999.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46376">
        <property type="protein sequence ID" value="CUO46376"/>
        <property type="gene ID" value="ERS852478_02893"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO46376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="127" mass="14732" checksum="599650341D57ADCE" modified="2016-09-07" version="1">MPKRNPRRTDKEWLDLIQECRSSGLSDKCWCQEHHIHTSNFYYQIRRLRQKACEIPEPVHSSFSGKQEVVPLSFEEPAVCPSSVQLKTDTIPDSVIKITYHSFQIEITNAADRETIFHTLSALQDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FIE0</accession>
    <name>A0A174FIE0_9FIRM</name>
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        <submittedName>
            <fullName evidence="4">Polyol:NADP oxidoreductase</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">por</name>
        <name evidence="4" type="ORF">ERS852478_02988</name>
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    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO49287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201054.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49287">
        <property type="protein sequence ID" value="CUO49287"/>
        <property type="gene ID" value="ERS852478_02988"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008926">
        <property type="term" value="F:mannitol-1-phosphate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol_dh" evidence="2">
        <location>
            <begin position="39"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol_dh_C" evidence="3">
        <location>
            <begin position="240"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO49287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="538" mass="59823" checksum="CDA133DEA83F4F15" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FIV1</accession>
    <name>A0A174FIV1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Arabinose import ATP-binding protein AraG</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Ribose import ATP-binding protein RbsA</fullName>
            <ecNumber evidence="5 9">3.6.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">araG_1</name>
        <name evidence="6" type="synonym">araG</name>
        <name evidence="9" type="synonym">rbsA_3</name>
        <name evidence="9" type="ORF">BWLFYP14_03527</name>
        <name evidence="5" type="ORF">ERS852478_03012</name>
        <name evidence="6" type="ORF">ERS852523_03216</name>
        <name evidence="8" type="ORF">GT712_01440</name>
        <name evidence="7" type="ORF">GT728_10125</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.17" evidence="5 9"/>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000042">
        <property type="protein sequence ID" value="CUP90421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000021">
        <property type="protein sequence ID" value="MZL33545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705031.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000010_gene2794"/>
    <dbReference type="EnsemblBacteria" id="CUO50194">
        <property type="protein sequence ID" value="CUO50194"/>
        <property type="gene ID" value="ERS852478_03012"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP90421">
        <property type="protein sequence ID" value="CUP90421"/>
        <property type="gene ID" value="ERS852523_03216"/>
    </dbReference>
    <dbReference type="GeneID" id="66495450"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="261"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO50194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP90421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS87787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX67252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="506" mass="55910" checksum="BAE5C05CCA922C83" modified="2016-09-07" version="1">MEQNVVLEMRDISKNFTGVRALSHVDFTLRKGEIHALMGENGAGKSTLIKVLTGVHEFESGTIHMAGNSNAIINHSPQEAQANGISTVYQEVNLCPNLTVAENLFIGREPRKMGMIDWKQMNERSGKLLESLDIHVPPTQMLDECSIAIQQMIAIARAVDMKCQVLILDEPTSSLDDDEVEKLFVLMRRLRDEGVGIIFVTHFLEQVYAVCDRITVLRNGELVGEYETKDLPRVMLVAKMMGKDFDDLADIKGDHKDKRITDAEPVIEAKGLSHKGTIKPFDITINKGEVIGLTGLLGSGRSELVRAIYGADKADTGTLKVKGKEVKINTPLDAMKLGMAYLPEDRKAEGIIADLSVRENIIIALQAKRGMFHPLSKKEMEDAADKYIKLLQIKTASRETPIKSLSGGNQQKVILGRWLLTNPDYLILDEPTRGIDIGTKTEIQKLVLDLADQGMAVTFISSEVEEMLRTCSRMAVLRDGQKVGELEEDELSQSGVMKAIAGGDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FVC1</accession>
    <name>A0A174FVC1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO52756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006858660.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52756">
        <property type="protein sequence ID" value="CUO52756"/>
        <property type="gene ID" value="ERS852478_03083"/>
    </dbReference>
    <dbReference type="GeneID" id="61432725"/>
    <dbReference type="eggNOG" id="ENOG5031AIZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024760">
        <property type="entry name" value="HTH_dom_conjug_TS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12645">
        <property type="entry name" value="HTH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_16" evidence="1">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO52756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="85" mass="9619" checksum="7B7FAD18DE4AC3BE" modified="2016-09-07" version="1">MNGLNGKPTEYPENALVPYPVILAASKGDPDAMKIVLQHFSGYIASLSMRKLYDERGNVYFGVDEEIRERLQAKLMRAILTFRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G2L3</accession>
    <name>A0A174G2L3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="6 14">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ptsI_2</name>
        <name evidence="21" type="ORF">ERS852478_03187</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="6 14"/>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201224.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56221">
        <property type="protein sequence ID" value="CUO56221"/>
        <property type="gene ID" value="ERS852478_03187"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="21" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="14 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="20">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="18">
        <location>
            <begin position="151"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="19">
        <location>
            <begin position="249"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="16">
        <location>
            <begin position="449"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="15">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CUO56221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="544" mass="61990" checksum="7DA966116BBE4E11" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GHC5</accession>
    <name>A0A174GHC5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">DNA replication and repair protein RecF</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">recF_2</name>
        <name evidence="5" type="ORF">BWLFYP14_03005</name>
        <name evidence="2" type="ORF">ERS852478_03338</name>
        <name evidence="4" type="ORF">GT712_03905</name>
        <name evidence="3" type="ORF">GT728_00050</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994060.1">
        <property type="nucleotide sequence ID" value="NZ_WWVL01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61341">
        <property type="protein sequence ID" value="CUO61341"/>
        <property type="gene ID" value="ERS852478_03338"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="25"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO61341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL31623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="338" mass="38316" checksum="6C73B1E2129265C1" modified="2016-09-07" version="1">MPLTKIAAENFTVFEDIKIPFCEGLNVLVGENGVGKTHIMKLAYAACQASKHDVSFSQKTTMLFRPDQSGIGRLVNRGKSGSNKAMVSVESDTAKIGMTFSTKTRKWDAEINSEEKWEKQMSDLTSVFIPAKEILSNAWNLDAAVKMGNVEFDDTYLDIIAAAKIDISRGVDSTVRKKYLDILQKISNGKVTLHEDRFYLKPGTQAKLEFNLVAEGLRKIALLWQLIKNGTLEKGSVLFWDEPEANINPKYIPVLAELLIMLETEGVQIFVSTHDYFLSKYIEVKRRQDSKLQYISLYKNENNKVLCEIAPEFELLEHNAIMDTFRQLYREEIGVALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GJS4</accession>
    <name>A0A174GJS4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">30S ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpsA_2</name>
        <name evidence="2" type="ORF">ERS852478_03388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO62872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201359.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62872">
        <property type="protein sequence ID" value="CUO62872"/>
        <property type="gene ID" value="ERS852478_03388"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="107"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="194"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="277"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO62872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="358" mass="39360" checksum="7A9E0F6877FBA41B" modified="2016-09-07" version="1">MSELSFEQMLEDSVKTIRNGEIVQGTVIDVKEDEIILNIGYKADGIITKNEYSNDASLVLTDAVHVGDTMEAKVLKVNDGEGQVTLTYKRLAAEKGNKRLEEAFENQEVLKAPVTQVLDGGLCVNVDEARVFIPASLVSDTYEKDLSKYADQEIEFVITEFNPRRRRIIGNRKQLLLAEKAEKQKELMEKIHVGDTIEGTVKNVTDFGAFIDLGGADGLLHISEMSWGRVENPKKVFTVGETLKVLIKEINGDKIALSLKFPEANPWLTAAEDFAVGNVVKGKVARMTDFGAFVELAPGVDALLHVSQISKEHVAKPADVLSIGQEIEAKVVDFNGEDKKISLSMKALEAPAEEATEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H8T7</accession>
    <name>A0A174H8T7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Int-Tn_8</name>
        <name evidence="9" type="ORF">ERS852478_03603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201462.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69429">
        <property type="protein sequence ID" value="CUO69429"/>
        <property type="gene ID" value="ERS852478_03603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008907">
        <property type="term" value="F:integrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075713">
        <property type="term" value="P:establishment of integrated proviral latency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044826">
        <property type="term" value="P:viral genome integration into host DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004191">
        <property type="entry name" value="Integrase_Tn916-type_DNA-bd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02920">
        <property type="entry name" value="Integrase_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="SSF54171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0229">DNA integration</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1179">Viral genome integration</keyword>
    <keyword evidence="4" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="8">
        <location>
            <begin position="87"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="7">
        <location>
            <begin position="191"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO69429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="425" mass="48849" checksum="E97028C51CC5B5CA" modified="2016-09-07" version="1">MPRKERDEKRRDNKGRLLKSGESQRSDGRYAYKYINTFGEPQFVYSWKLVPTDKVPAGKRPCLSLREKIKQIQKDLDDGIDTIGKKMTVCQLYEKYTRQRGNVRKGTQKSRQQLMKLLSEDKLGAASIDSVKLSDAKEWALRMQEKGVAYNTICNSKRSLKAIFYMAVQDDCLRKNPFDFQINEVINDDTVPKVPLTPTQENELLDFMQNDPVYAKYYDEVVILLETGLRISELCGLTPADLNFEKRFVNVDHQLLRSTEDGYYTEAPKTESGFRQVPMSAAAYEAFERVLKKRRDVRCIEVDGYKDFLFLNRDGLPKTAVNYDAMFKCLAKKYNKCHKEPLPDVMTPHTMRHTFCTRMANAGMNPKALQYIMGHANIVMTLNYYAHATFHSAQEEMERLQAKAKTTAEAKPEPAAESAEETKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HBM9</accession>
    <name>A0A174HBM9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="8">KARI</shortName>
            <ecNumber evidence="8">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="8">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">ilvC</name>
        <name evidence="15" type="ORF">BWLFYP14_00085</name>
        <name evidence="12" type="ORF">ERS852478_03640</name>
        <name evidence="14" type="ORF">GT712_04100</name>
        <name evidence="13" type="ORF">GT728_01750</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="13 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 19">BIOML-A1</strain>
            <strain evidence="14 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL31957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704844.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70638">
        <property type="protein sequence ID" value="CUO70638"/>
        <property type="gene ID" value="ERS852478_03640"/>
    </dbReference>
    <dbReference type="GeneID" id="66494337"/>
    <dbReference type="eggNOG" id="COG0059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="10">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="11">
        <location>
            <begin position="184"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="26"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO70638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL31957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS88293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VUX66532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="339" mass="37329" checksum="8E3B13BAB6DB33C1" modified="2016-09-07" version="1">MANKIFYQEDCNLSLLDGKKIAIIGYGSQGHAHALNLKDSGCDVIIGLYEGSKSWKRAEEQGFKVYTAAEAAKQADIIMILINDELQAKLYKESIEPNLEEGNMLMFAHGFNIHFGCIKPPKNVDVTMIAPKAPGHTVRSEYQAGKGTPCLIAVEQDYTGKAQDLALAYGLGIGGARAGLLETTFRVETETDLFGEQAVLCGGVCALMQAGFETLVEAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKKAMKKILSDIQDGTFAKDFLLDMSDAGAQVHFKAMRKKASEHQSEKVGEEIRKLYSWNGEDKLINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HE82</accession>
    <name>A0A174HE82_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphodiesterase YaeI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71687">
        <property type="protein sequence ID" value="CUO71687"/>
        <property type="gene ID" value="ERS852478_03680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="163" mass="17938" checksum="6F6B338B843D8933" modified="2016-09-07" version="1">MSQYDELKAELENTGVVVLEDKAMQLEYNGDDITLIGLSDPSFTLKGDMFGEVPAMVDTKLRGLIGDKDNYTILLSHRPELFEAYVNCGVDLVFSGHAHGGQFRLPFIGGLVAPNQGLFPKYDAGLYTKGDTNMIVCRGLGNSIIPIRFNNRPEIVLLELIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HEN5</accession>
    <name>A0A174HEN5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03675</name>
        <name evidence="2" type="ORF">GT712_06810</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000010">
        <property type="protein sequence ID" value="MZS88787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201486.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000072.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71590">
        <property type="protein sequence ID" value="CUO71590"/>
        <property type="gene ID" value="ERS852478_03675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO71590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS88787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="188" mass="21790" checksum="C67A2D358ED18864" modified="2016-09-07" version="1">MSYRNANYSAFYVSEPFSESNLGANSTHDFVYYNMLRMWRGEDNSFPFNDAHDKTYNVRDGSDWEKTLKPRLHTRLDNSKNIILFLSSITANSRALREEMNYGISTKGLPVIVIYPDYDKKSDIVDSNGNFKKQIKDLWDKLPAFRDNMSSVATLHIPCTKSLITSALNDEDFMVNTMADAKRYFYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HFD6</accession>
    <name>A0A174HFD6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chorismate--pyruvate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03744</name>
        <name evidence="3" type="ORF">GT712_18750</name>
        <name evidence="2" type="ORF">GT728_19120</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 5 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A1</strain>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000046">
        <property type="protein sequence ID" value="CUO73564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000080">
        <property type="protein sequence ID" value="MZL35226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000063">
        <property type="protein sequence ID" value="MZS91021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019160770.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73564">
        <property type="protein sequence ID" value="CUO73564"/>
        <property type="gene ID" value="ERS852478_03744"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033DKE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO73564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL35226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS91021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="57" mass="6719" checksum="6C58D52B5D2E5D42" modified="2016-09-07" version="1">MLVCDYIVESIDGDYAHLRRTDLPEEELKLVARALLPFEITEGCRLHYEMMQYSIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HND9</accession>
    <name>A0A174HND9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000049">
        <property type="protein sequence ID" value="CUO74817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201526.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000049.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74817">
        <property type="protein sequence ID" value="CUO74817"/>
        <property type="gene ID" value="ERS852478_03786"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033CIB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO74817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="71" mass="8068" checksum="AAD1C3BE1AB9A50A" modified="2016-09-07" version="1">MIYTVKRIDEDLDFGCEERPKGMPVMAIVTLTNSSGEEIRIKAEDAMLYECNINEGDKVCLDVDNKLEKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JEK2</accession>
    <name>A0A174JEK2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">nusA</name>
        <name evidence="9" type="ORF">ERS852478_02026</name>
        <name evidence="10" type="ORF">ERS852523_00055</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
            <strain evidence="10 12">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO95615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380143.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2221"/>
    <dbReference type="EnsemblBacteria" id="CUO16599">
        <property type="protein sequence ID" value="CUO16599"/>
        <property type="gene ID" value="ERS852478_02026"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95615">
        <property type="protein sequence ID" value="CUO95615"/>
        <property type="gene ID" value="ERS852523_00055"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1" evidence="8">
        <location>
            <begin position="133"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="346"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO16599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO95615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="406" mass="44757" checksum="154F94B57895AA21" modified="2016-09-07" version="1">MSRELKEALDILEKEKSISKDTLLEAIEQSLIQACKNHFGKADNVHVTINPETCDFSVYADRSIVEYVEDPAMEISLADALKITSRAEIGGMIQVPIQSKEFGRIATQNAKNVILQKIREEERKVLYDEYYGKEKEVVTGIVQRVMGKNVSINLGKADAVLSENEQVKGETFQPTERIKVYILEVKDTPKGPRILVSRTHPGLVKRLFESEVAEVKDGTVEIKSIAREAGSRTKIAVWSNDPDVDAVGACVGMNGARVNAVVEELRGEKIDIINWDENPAILIENALSPAKVIAVMADPDEKTALVVVPDYQLSLAIGKEGQNARLAARLTGFKIDIKSETQAKEAGDFYDYDDDETAEDAAEASAEETSAEDSLTEETEAEEVSEEVPVEEEPQAQEAGENEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K553</accession>
    <name>A0A174K553_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Acyl carrier protein</fullName>
            <shortName evidence="3">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acpP_1</name>
        <name evidence="3 9" type="synonym">acpP</name>
        <name evidence="11" type="synonym">acpP_2</name>
        <name evidence="11" type="ORF">BWLFYP14_03094</name>
        <name evidence="7" type="ORF">ERS852478_01140</name>
        <name evidence="8" type="ORF">ERS852523_00461</name>
        <name evidence="10" type="ORF">GT712_03465</name>
        <name evidence="9" type="ORF">GT728_00755</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="3">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP07293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704123.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2162"/>
    <dbReference type="EnsemblBacteria" id="CUN81578">
        <property type="protein sequence ID" value="CUN81578"/>
        <property type="gene ID" value="ERS852478_01140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07293">
        <property type="protein sequence ID" value="CUP07293"/>
        <property type="gene ID" value="ERS852523_00461"/>
    </dbReference>
    <dbReference type="GeneID" id="66493976"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 3 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3 4">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN81578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP07293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL31763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS88170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX66818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="77" mass="8420" checksum="C0B987182CB7E62A" modified="2016-09-07" version="1">MLEKMSEMIAEQLNCDAAGITAETSFKDDLGADSLDLFELVMALEDEYNIEIPAEDLTDLTTVGAVMDYLKNKGVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KT64</accession>
    <name>A0A174KT64_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Inner membrane ABC transporter permease protein ycjP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ycjP_3</name>
        <name evidence="7" type="synonym">ycjP_5</name>
        <name evidence="7" type="ORF">ERS852478_00663</name>
        <name evidence="8" type="ORF">ERS852523_00683</name>
        <name evidence="10" type="ORF">GT712_03375</name>
        <name evidence="9" type="ORF">GT728_03595</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
            <strain evidence="8 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BIOML-A1</strain>
            <strain evidence="10 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN63785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP14051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055149585.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000015_gene3743"/>
    <dbReference type="EnsemblBacteria" id="CUN63785">
        <property type="protein sequence ID" value="CUN63785"/>
        <property type="gene ID" value="ERS852478_00663"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP14051">
        <property type="protein sequence ID" value="CUP14051"/>
        <property type="gene ID" value="ERS852523_00683"/>
    </dbReference>
    <dbReference type="GeneID" id="66493435"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN63785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP14051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL32300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS88154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="280" mass="31112" checksum="FB196325B9873798" modified="2016-09-07" version="1">MDNMTGAEKAKEIRNSIFALLIAFIFLFPIYWLIQISFKSDAETFGKVLTYFPHDFTFEPWLENLTDKTFLISLKNSFLNGLLTMAIALVLGVPAAYGMGRYRVKGGNVFLLTFLISQMLPPSLTLTPMYLIFSKLGFLGNHLTAPVAIAASSIPFVIVTLRPYFRSIPVSLDEAARLDGCGSVKAFLMVMLPAVKTGIITIMVISFLNGWNDLVYSMTFNVAETMRPLTANIYKFQSAYGTRWNCIMAYGAILVLPVILMFIFLQKYIVGGLVAGAVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KUP1</accession>
    <name>A0A174KUP1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rplT</name>
        <name evidence="11" type="ORF">BWLFYP14_01811</name>
        <name evidence="7" type="ORF">ERS852478_00697</name>
        <name evidence="8" type="ORF">ERS852523_00647</name>
        <name evidence="10" type="ORF">GT712_03205</name>
        <name evidence="9" type="ORF">GT728_03720</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP13010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380175.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000015_gene3702"/>
    <dbReference type="EnsemblBacteria" id="CUN64931">
        <property type="protein sequence ID" value="CUN64931"/>
        <property type="gene ID" value="ERS852478_00697"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13010">
        <property type="protein sequence ID" value="CUP13010"/>
        <property type="gene ID" value="ERS852523_00647"/>
    </dbReference>
    <dbReference type="GeneID" id="66493474"/>
    <dbReference type="eggNOG" id="COG0292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN64931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP13010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL32324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS88120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX65048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="118" mass="13171" checksum="FD8D143E064E8DF5" modified="2016-09-07" version="1">MARIKGGLNAKKKHNRTLKLAKGYRGARSKQYRVAKQSVMRALASSYAGRKQKKRQFRQLWIARINAAARMNGLSYSKLMHGLKVANIDINRKMLAELAVNDAEGFTALAEIAKKAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L2L7</accession>
    <name>A0A174L2L7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Sporulation protein YtfJ (Spore_YtfJ)</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_00973</name>
        <name evidence="1" type="ORF">ERS852478_01505</name>
        <name evidence="2" type="ORF">ERS852523_00774</name>
        <name evidence="4" type="ORF">GT712_13025</name>
        <name evidence="3" type="ORF">GT728_11030</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP17071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000024">
        <property type="protein sequence ID" value="MZL33717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000026">
        <property type="protein sequence ID" value="MZS89968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993849.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1360"/>
    <dbReference type="EnsemblBacteria" id="CUN96386">
        <property type="protein sequence ID" value="CUN96386"/>
        <property type="gene ID" value="ERS852478_01505"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17071">
        <property type="protein sequence ID" value="CUP17071"/>
        <property type="gene ID" value="ERS852523_00774"/>
    </dbReference>
    <dbReference type="GeneID" id="66492597"/>
    <dbReference type="eggNOG" id="COG3874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014229">
        <property type="entry name" value="Spore_YtfJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09579">
        <property type="entry name" value="Spore_YtfJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN96386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP17071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX63487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="123" mass="12904" checksum="9928BAFF46B38BA1" modified="2016-09-07" version="1">MANENNFKETVNSLFKGMDSFISAKTVVGEAIHVGDTIILPLMDVSFGVGAGAFSGEKKDNGGGGMAGKMTPCAVLVIQNGTTKLVNVKNQDGLTKILDMVPDFVDRFTSGKGDEESVGESEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LUV3</accession>
    <name>A0A174LUV3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01457</name>
        <name evidence="2" type="ORF">ERS852523_01037</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP25505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993778.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94697">
        <property type="protein sequence ID" value="CUN94697"/>
        <property type="gene ID" value="ERS852478_01457"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP25505">
        <property type="protein sequence ID" value="CUP25505"/>
        <property type="gene ID" value="ERS852523_01037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022225">
        <property type="entry name" value="Phage_tail_fibre"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12571">
        <property type="entry name" value="DUF3751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN94697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP25505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="123" mass="13262" checksum="EED19D53E02955D4" modified="2016-09-07" version="1">MEGKVTVVGRTKILRARAGEITLPKIVGFAFGSGGSNGSTVLSPGETLKNEFLRKAVDGHTLKTNENKCEYYCTLNGSEANGKSISEIGLYDSEGDIIMIANFLPKGKDSNVSMRFEIDDVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NBW8</accession>
    <name>A0A174NBW8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Phosphate propanoyltransferase</fullName>
            <ecNumber evidence="4 7">2.3.1.222</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pduL_2</name>
        <name evidence="10" type="synonym">pduL</name>
        <name evidence="12" type="synonym">pduL_1</name>
        <name evidence="12" type="ORF">BWLFYP14_01560</name>
        <name evidence="8" type="ORF">ERS852478_02314</name>
        <name evidence="9" type="ORF">ERS852523_01627</name>
        <name evidence="11" type="ORF">GT712_12790</name>
        <name evidence="10" type="ORF">GT728_12245</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>phosphate + propanoyl-CoA = CoA + propanoyl phosphate</text>
            <dbReference type="Rhea" id="RHEA:28046"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58933"/>
            <dbReference type="EC" id="2.3.1.222"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Polyol metabolism; 1,2-propanediol degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PduL family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.222" evidence="4 7"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP44088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000029">
        <property type="protein sequence ID" value="MZL33949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705578.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000086_gene4009"/>
    <dbReference type="EnsemblBacteria" id="CUO26676">
        <property type="protein sequence ID" value="CUO26676"/>
        <property type="gene ID" value="ERS852478_02314"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP44088">
        <property type="protein sequence ID" value="CUP44088"/>
        <property type="gene ID" value="ERS852523_01627"/>
    </dbReference>
    <dbReference type="GeneID" id="66494431"/>
    <dbReference type="eggNOG" id="COG4869">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00621"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051144">
        <property type="term" value="P:propanediol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008300">
        <property type="entry name" value="PTAC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39453">
        <property type="entry name" value="PTHR39453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06130">
        <property type="entry name" value="PTAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010130">
        <property type="entry name" value="PduL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO26676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP44088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL33949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS89924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX64706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="214" mass="22996" checksum="0BB623C1CD51A1C6" modified="2016-09-07" version="1">MESNNIELITRMVIQAINQNEKKGDGFMVPIGVSARHIHLTQEHVEALFGPGYQLTKKKELMGGQFASNETVTIVGLKLRAIENVRILGPVRKASQVEVSATDAIKLGMNVPVRESGDVAGSAPIAIVGPKGAVYLKEGCIVAMRHIHMSPKDAQAAGVKDGDIVSVKADNERGTIFNQVKIRVDDSFTLEMHIDTDEANAAKIATGTTVTIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NBX1</accession>
    <name>A0A174NBX1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Ribosomal RNA large subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.191</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rlmI</name>
        <name evidence="5" type="ORF">ERS852478_03523</name>
        <name evidence="6" type="ORF">ERS852523_01602</name>
        <name evidence="8" type="ORF">GT712_12670</name>
        <name evidence="7" type="ORF">GT728_12370</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
            <strain evidence="6 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">BIOML-A1</strain>
            <strain evidence="8 11">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.191" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP43459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000029">
        <property type="protein sequence ID" value="MZL33974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025581119.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000136_gene975"/>
    <dbReference type="EnsemblBacteria" id="CUO67123">
        <property type="protein sequence ID" value="CUO67123"/>
        <property type="gene ID" value="ERS852478_03523"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP43459">
        <property type="protein sequence ID" value="CUP43459"/>
        <property type="gene ID" value="ERS852523_01602"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="4"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO67123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP43459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS89900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="400" mass="44997" checksum="0C04B5D9DDE3C7EB" modified="2016-09-07" version="1">MGMAVVTLKKGEGRLLKSGGMWIFDNEIDTVMGNFENGDIVLVHDFDGYPMGRGFINTNSKITVRLMTRDENVDINEELLEKRVRDAWEYRKKVVDTGCCRLIFAEADFLPGIVVDKFSDVLVVQSLALGIDRFKETIVELLRKVLAEDGITIRGVYERSDVKVRKQEGMEMVKGFIGPEFPTLVQIEENGVKYEVDVKDGQKTGFFLDQKYNRLAIQKLCKNAKVLDCFTHTGSFALNAGIAGAASVTGVDASQLAVDQATANATLNGLSDNVKFICEDVFELLPELEEKGEKFDVVILDPPAFTKSRNSIKNAVKGYREINLRAMKLVKDGGFLATCSCSHFMDYELFTKTIGQAAKNVHKRLRQVEYRTQAPDHPILWAADESYYLKFYIFQVCNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NIA7</accession>
    <name>A0A174NIA7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">srrA_3</name>
        <name evidence="11" type="synonym">srrA_1</name>
        <name evidence="15" type="ORF">BWLFYP14_02864</name>
        <name evidence="11" type="ORF">ERS852478_02204</name>
        <name evidence="12" type="ORF">ERS852523_01694</name>
        <name evidence="14" type="ORF">GT712_11305</name>
        <name evidence="13" type="ORF">GT728_11145</name>
    </gene>
    <organism evidence="12 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 16">2789STDY5834863</strain>
            <strain evidence="12 17">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="13 19 20" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 20">BIOML-A1</strain>
            <strain evidence="14 19">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="15 18" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000015">
        <property type="protein sequence ID" value="CUP46368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000025">
        <property type="protein sequence ID" value="MZL33737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993338.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000021_gene1711"/>
    <dbReference type="EnsemblBacteria" id="CUO22756">
        <property type="protein sequence ID" value="CUO22756"/>
        <property type="gene ID" value="ERS852478_02204"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP46368">
        <property type="protein sequence ID" value="CUP46368"/>
        <property type="gene ID" value="ERS852523_01694"/>
    </dbReference>
    <dbReference type="GeneID" id="66493395"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="130"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="130"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO22756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP46368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL33737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS89642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VUX66489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="229" mass="26524" checksum="72B84C2671654E40" modified="2016-09-07" version="1">MSRILIIEDEEAIADLEKDYLELSGFEVEICNRGDTGLTRALNEEFDLIILDLMLPEVDGFDICRQVRQEKNTPIIMVSAKKDDIDKIRGLGLGADDYMTKPFSPSELVARVKAHMDRYNRLIGSNVRKNDIVEIRGIKIDKTARRVWVNGEEKTFTSKEYDLLTFLAENPNRVFTKEELFREIWDMESVGDIATVTVHIKKIREKIEFNTAKPQYIETIWGVGYRFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NTT3</accession>
    <name>A0A174NTT3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_03248</name>
        <name evidence="2" type="ORF">ERS852478_00608</name>
        <name evidence="3" type="ORF">ERS852523_01815</name>
        <name evidence="5" type="ORF">GT712_08480</name>
        <name evidence="4" type="ORF">GT728_05365</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000016">
        <property type="protein sequence ID" value="CUP49950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000009">
        <property type="protein sequence ID" value="MZL32648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000014">
        <property type="protein sequence ID" value="MZS89106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX66971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706141.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000022_gene1738"/>
    <dbReference type="EnsemblBacteria" id="CUN60907">
        <property type="protein sequence ID" value="CUN60907"/>
        <property type="gene ID" value="ERS852478_00608"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP49950">
        <property type="protein sequence ID" value="CUP49950"/>
        <property type="gene ID" value="ERS852523_01815"/>
    </dbReference>
    <dbReference type="GeneID" id="66492505"/>
    <dbReference type="eggNOG" id="ENOG5032UC0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN60907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP49950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="144" mass="16542" checksum="256C42235B9267CE" modified="2016-09-07" version="1">MLNEEKIKIMNKLAMYEQGEGKKYLPVSRYYRSDYIGLAMIKNFFLVTIGYCLILAGIAAYFAEYLIDNVHKMNLVSLGVEVILGYVAVLVLFSVLTYIQYTVKYHKAKKSVKNYYEELTQLSKIYGREDKKSSARGVTGGYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174P077</accession>
    <name>A0A174P077_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpmA</name>
        <name evidence="10" type="ORF">BWLFYP14_02597</name>
        <name evidence="6" type="ORF">ERS852478_00099</name>
        <name evidence="7" type="ORF">ERS852523_01891</name>
        <name evidence="9" type="ORF">GT712_00970</name>
        <name evidence="8" type="ORF">GT728_02950</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP52170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000005">
        <property type="protein sequence ID" value="MZL32177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703124.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000020_gene127"/>
    <dbReference type="EnsemblBacteria" id="CUN43680">
        <property type="protein sequence ID" value="CUN43680"/>
        <property type="gene ID" value="ERS852478_00099"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP52170">
        <property type="protein sequence ID" value="CUP52170"/>
        <property type="gene ID" value="ERS852523_01891"/>
    </dbReference>
    <dbReference type="GeneID" id="66495926"/>
    <dbReference type="eggNOG" id="COG0211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN43680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP52170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL32177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS87696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX66225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="95" mass="10524" checksum="81DA1A9CCA719B1A" modified="2016-09-07" version="1">MMKMNLQLFAHKKGVGSTKNGRDSESKRLGAKRADGQFVKAGNILYRQRGTKIHAGENVGCGKDYTLFALKDGVVRFTRKGRDKKQVSIVPVEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SV63</accession>
    <name>A0A174SV63_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">Trigger factor</fullName>
            <shortName evidence="9">TF</shortName>
            <ecNumber evidence="9">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">tig_2</name>
        <name evidence="9" type="synonym">tig</name>
        <name evidence="18" type="ORF">BWLFYP14_00875</name>
        <name evidence="14" type="ORF">ERS852478_03173</name>
        <name evidence="15" type="ORF">ERS852523_03508</name>
        <name evidence="17" type="ORF">GT712_16140</name>
        <name evidence="16" type="ORF">GT728_16485</name>
    </gene>
    <organism evidence="15 20">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 19 20" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 19">2789STDY5834863</strain>
            <strain evidence="15 20">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="16 22 23" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 23">BIOML-A1</strain>
            <strain evidence="17 22">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="18 21" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="9">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000053">
        <property type="protein sequence ID" value="CUP98439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000051">
        <property type="protein sequence ID" value="MZL34747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000041">
        <property type="protein sequence ID" value="MZS90548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000024">
        <property type="protein sequence ID" value="VUX63397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705993.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000094_gene757"/>
    <dbReference type="EnsemblBacteria" id="CUO55447">
        <property type="protein sequence ID" value="CUO55447"/>
        <property type="gene ID" value="ERS852478_03173"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP98439">
        <property type="protein sequence ID" value="CUP98439"/>
        <property type="gene ID" value="ERS852523_03508"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="13">
        <location>
            <begin position="163"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO55447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUP98439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZL34747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MZS90548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VUX63397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="428" mass="47956" checksum="02A35DE596765658" modified="2016-09-07" version="1">MSLQVEKMEKNMAKLTIEVAAEDLEKAMQNAYQKAKGRISIPGFRKGKAPRKMIEQMYGKGVFLEDAVNALIPEHYSKALAECELEIVSQPTIDITQAEPGKAFIFTAEVAVKPEVTLGDYKGVEVPKTEITVTDEDVEAELKKEQEKNSRTISVEDRAAQLNDIVTIDFEGSVDGVPFDGGQATEYPLTLGSNTFIPGFEEQLVGAKVGDDVDVKVTFPEEYQAKELAGKEAIFKCAVKKIEAKELPELDDDFAKDVSEFDTLAEYKEHVKTNLEDKKADEAKRAKEDAAVDKAIENAQMDIPEAMLMTQCRQMLDDFSRRMQSQGLSMDQYFQFTGMTADKMMEDMKPQALKRIQTRLVLEKVAEVENIQPTEEEVNEEISKMAEAYKMEADKLKELLGERELEQMKKDMAVQKAVTVIADAAKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WPE0</accession>
    <name>A0A173WPE0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase</fullName>
            <ecNumber evidence="2">2.4.2.53</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Undecaprenyl-phosphate mannosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arnC_1</name>
        <name evidence="5" type="ORF">BWLFYP14_02526</name>
        <name evidence="2" type="ORF">ERS852478_00026</name>
        <name evidence="4" type="ORF">GT712_07775</name>
        <name evidence="3" type="ORF">GT728_12755</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.53" evidence="2"/>
    <dbReference type="EC" id="2.4.1.54" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000031">
        <property type="protein sequence ID" value="MZL34047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703000.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41429">
        <property type="protein sequence ID" value="CUN41429"/>
        <property type="gene ID" value="ERS852478_00026"/>
    </dbReference>
    <dbReference type="GeneID" id="66492906"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099621">
        <property type="term" value="F:undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047267">
        <property type="term" value="F:undecaprenyl-phosphate mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN41429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="239" mass="27596" checksum="CEDD8CBEFF25BD53" modified="2016-09-07" version="1">MDKLYIVIPAYNEQDNIEQVINDWYPVIEKHNGNGQSRLIVIDDGSKDSTYEKLKQCTKTRPLLIPITKPNGGHGATVLYGYKYALKNGADYIFQTDSDGQTLPEEFEPFWKRRQKYDMVIGWRKDRQDGISRVFVTKTLKLVIRICFGVNLTDANTPYRLMKAETMARYIHLIPKDFNLSNVLLAVIYKKKGCSIKFLPVTFRPRQGGVNSINMKKICKIGKQAVIDFVKLNRIIRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WXG8</accession>
    <name>A0A173WXG8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">apbE_1</name>
        <name evidence="11" type="ORF">ERS852478_00076</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43015">
        <property type="protein sequence ID" value="CUN43015"/>
        <property type="gene ID" value="ERS852478_00076"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948257" description="FAD:protein FMN transferase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN43015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="344" mass="37423" checksum="8B1A8EE412D3C946" modified="2016-09-07" version="1">MTNRRSFVLGLFITASLLCTSRTAWGNSEINTYTKTDFAMDTVVSETLYTTGEDITADVISALKDVEENWISWTKESSQIYQINQNAGNTTTVSDETATCLKQVLDLSKDSDGAMDPTMGRVIRLWDIDGEDPHIPSDDKLNSLLENVGYDKVTLDGNKVTMPEGVTLDLGAAGKGIGCDAAKKILDADKHVSGMILNLGGSSVMSYGSKPDGSAWQVAVTDPRDTEGDYLGVVTLNGTEFLSTSGDYEKYFVEDGVRYHHILDPATGYPARSGLTSVTVVCDDGLNADGLSTACFVLGKEKAEELLKKYNADGLFVDDSDHVWMTEGMKERFQLLKDTYSISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X594</accession>
    <name>A0A173X594_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF4203 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_00213</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381206.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46744">
        <property type="protein sequence ID" value="CUN46744"/>
        <property type="gene ID" value="ERS852478_00213"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50331B3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="DUF4203"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040236">
        <property type="entry name" value="TMEM198"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247">
        <property type="entry name" value="PTHR31247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="DUF4203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4203" evidence="7">
        <location>
            <begin position="30"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN46744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="258" mass="27923" checksum="69610CAE1CE76F76" modified="2016-09-07" version="1">MVNMTDIFGNALSIAGSFMDSDLVNRFMMVIFAVILVFGVLNCILGYRLLRFWMMLGGFLVGGGLALVVVHTMGIQEKSTMLIAALAAGVVFAVIAFLIYKAGVFILAAGIGWAASIYFLHPTSSAVFFACILIGVALGSMAVKYCREVLIVATSLIGGIMAGVSLAQLGNLADIPYGLGMSVGFAVLGMLIQFAINKPVSDEEDEETVDEESTEQIYRRNQDLRQDQSFKQSQDRDMEESIYARGQKGQARKNGKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XFJ5</accession>
    <name>A0A173XFJ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oligo-1,6-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">malL_1</name>
        <name evidence="3" type="ORF">ERS852478_00282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199544.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIOY010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49796">
        <property type="protein sequence ID" value="CUN49796"/>
        <property type="gene ID" value="ERS852478_00282"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="15"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN49796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="552" mass="63818" checksum="3F8A30379AA71258" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XG69</accession>
    <name>A0A173XG69_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase family, NAD-binding Rossmann fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577560.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50852">
        <property type="protein sequence ID" value="CUN50852"/>
        <property type="gene ID" value="ERS852478_00316"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN50852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="363" mass="42019" checksum="BDE03D8560B70F6B" modified="2016-09-07" version="1">MGKIRYGVIGSGWRAEFYIRIAKAVPDKFEFTAVLIRDKEKGRAFSEKFGVAVVNSLDELMKENPEFVVLAIKRGYVTDYLLQLFEKNIPVLAETPPGESQEDLQKLWKAYEKYQPRIQVAEQYFLQPLYASWHNAIERGLIGKVENINISSLHGYHGISMIRWMLGTKGIPCTIYGKRYEFSVTETYGREGMAFDGDTFICSRDRVTLEFDNGQIAFFDFSDPAQYHSFIRTRQLNIQGERGEIDDLTIRYLTEENIPVTQEINRIDLGVYGNQEWSHFAIMLGEEFLYKTPFVNARLNDDEIAVGSLLMGMHEYLKNGKEIYSLADALQDMYLCLKMEEAMADEYKPVYTEKQPWNSFLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XQF2</accession>
    <name>A0A173XQF2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Divergent AAA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00402</name>
        <name evidence="3" type="ORF">ERS852523_01592</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000013">
        <property type="protein sequence ID" value="CUP42790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53480">
        <property type="protein sequence ID" value="CUN53480"/>
        <property type="gene ID" value="ERS852478_00402"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP42790">
        <property type="protein sequence ID" value="CUP42790"/>
        <property type="gene ID" value="ERS852523_01592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlbA_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP42790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="159" mass="17532" checksum="6BEF69AA4134E13A" modified="2016-09-07" version="1">MEFKENLLEKSIKYMKSVVAFVNGTGGKIIFGIANKTREIVGFDKEDAFKKMDAIANAVSDSCEPAIIPDSTLQTVDGKTVIVVEIFEGRQQLRSWGILFERDGKDYPSNAFAILAGNGGLHVATQVSCKCAWLVEPQILYKKIGTHLLLLQRSFCLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y7K5</accession>
    <name>A0A173Y7K5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053028.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60102">
        <property type="protein sequence ID" value="CUN60102"/>
        <property type="gene ID" value="ERS852478_00585"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033UAG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN60102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="283" mass="32980" checksum="849DDE695C706F5B" modified="2016-09-07" version="1">MDIQILNIAELLLFVFMICICIRIYRQKKQKGKISLKTLIMFLINLIFYAMVTGTNYHRTHLGESKFQAGITYNNVRIFIYSIVFCLGLAIMKKMKKLASKWIITWAILCTVFLIVMSFCEIENAYVSFSTADQAEKYYGIEKNKIDEIYGEDSIEVLYLEDRQMNSKIIYKEEGGWKCTSHSEIKCLYNRADFKKDNTIVVRECTITGELYISVICGKKDNKDFQISDTQNTIFTKKEFVNKNGEQISYNGYLGKEKPKNYVIYLDGEEISIDWNESDIMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y9A8</accession>
    <name>A0A173Y9A8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Formate dehydrogenase H</fullName>
            <ecNumber evidence="17">1.2.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">fdhF</name>
        <name evidence="17" type="ORF">ERS852478_00574</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.2" evidence="17"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053035.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59736">
        <property type="protein sequence ID" value="CUN59736"/>
        <property type="gene ID" value="ERS852478_00574"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015942">
        <property type="term" value="P:formate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02790">
        <property type="entry name" value="MopB_CT_Formate-Dh_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02753">
        <property type="entry name" value="MopB_Formate-Dh-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041925">
        <property type="entry name" value="CT_Formate-Dh_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041924">
        <property type="entry name" value="Formate_Dh-H_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006478">
        <property type="entry name" value="Formate_DH_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01591">
        <property type="entry name" value="Fdh-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="16">
        <location>
            <begin position="80"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="14">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="14">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="15">
        <location>
            <begin position="220"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUN59736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="902" mass="99914" checksum="A842E071EE781CCD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YSZ2</accession>
    <name>A0A173YSZ2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="8">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">murE</name>
        <name evidence="14" type="ORF">BWLFYP14_01783</name>
        <name evidence="13" type="ORF">ERS852478_00738</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8 9">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993620.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66366">
        <property type="protein sequence ID" value="CUN66366"/>
        <property type="gene ID" value="ERS852478_00738"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 8 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="12">
        <location>
            <begin position="108"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="11">
        <location>
            <begin position="329"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="8">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="8">
        <location>
            <begin position="404"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="8">
        <location>
            <begin position="404"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="110"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="8">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN66366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX64992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="485" mass="53871" checksum="77DAC6BC56FE27F9" modified="2016-09-07" version="1">MKLISLLEKLEYTCLQGSTDQEVKNVVYDSRKVEEGSLFICIRGAVVDGHKFVPDVVAKGAKVLIVEEAVEAPEDVTVILVKDTRYAMAFISAAYFGYPAEKLKTIGITGTKGKTTTTYMVKSILENAGYKVGLIGTIEAIIGDKVIPAKNTTPESYVIQEYFHEMAEAGCDCVVMEVSSQGLMLHRTQGFVFDFGIFTNIEPDHIGPNEHKDFDDYLRCKSLLLKQCKVGIVNRDDEHFEKIIEGHTCSLETYGFSPEADLRAEDAKLVGGKGYLGISYHLKGLLDFHVEIDIPGKFSIYNSLTAIAICRHFKVSEENILKALKVAKVKGRIEMVKVSDDFTLMIDYAHNAMALESLLTTLKEYHPHRLVCLFGCGGNRSKLRRYEMGEVSGKLADLTIITSDNPRDEEPQAIIDDIKIGMAKTDGKYVEIPDRKEAIAYAIHHGEPGDIIVLAGKGHEDYQEIKGKKYPMDERVLIADILAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YVF4</accession>
    <name>A0A173YVF4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rpmE</name>
        <name evidence="12" type="ORF">BWLFYP14_01752</name>
        <name evidence="8" type="ORF">ERS852478_00768</name>
        <name evidence="9" type="ORF">ERS852523_00574</name>
        <name evidence="11" type="ORF">GT712_02915</name>
        <name evidence="10" type="ORF">GT728_04010</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP11169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993628.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000036_gene2417"/>
    <dbReference type="EnsemblBacteria" id="CUN67519">
        <property type="protein sequence ID" value="CUN67519"/>
        <property type="gene ID" value="ERS852478_00768"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11169">
        <property type="protein sequence ID" value="CUP11169"/>
        <property type="gene ID" value="ERS852523_00574"/>
    </dbReference>
    <dbReference type="GeneID" id="66493543"/>
    <dbReference type="eggNOG" id="COG0254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN67519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP11169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL32382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS88062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX64930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="67" mass="7598" checksum="DCD85CC6E83EC608" modified="2016-09-07" version="1">MREGIHPNYYQATVTCNCGNTFVTGSTKQDIHVEICSKCHPFYTGQQKAAQARGRIDKFNKKYGLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YXK8</accession>
    <name>A0A173YXK8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystine-binding periplasmic protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Sulfate starvation-induced protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fliY_1</name>
        <name evidence="4" type="ORF">BWLFYP14_01731</name>
        <name evidence="3" type="ORF">ERS852478_00790</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070102113.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68260">
        <property type="protein sequence ID" value="CUN68260"/>
        <property type="gene ID" value="ERS852478_00790"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="2">
        <location>
            <begin position="46"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN68260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="279" mass="31533" checksum="2521FE69E5DA2BC4" modified="2016-09-07" version="1">MRKNRKNDSHTRRKRICIAALLLAGSLIPGGCGIKKEKTSDSELPEIVIGIDYFEPYSYQTSDGEYKGIDVELAEEAFQRLGYQPEFEKVVWEDKEKLLSDGTIDCLWSCYSMNERENKYQWAGPYMYSRQMVVVRAESEIRTLQDLKGKRIAVQATTKAEDLFLHNIKSDLPHAEQVNCFSSSNELYAALRKNYADAIAGHEAMLGSLIQDGKGVYRMLEESPYKSELGIAFKKGTHEELAEKLTETLTEMQSEGITEKIVTKYGLDADETLPGGESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z7W6</accession>
    <name>A0A173Z7W6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="9">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">glgC_2</name>
        <name evidence="9" type="synonym">glgC</name>
        <name evidence="13" type="synonym">glgC_3</name>
        <name evidence="16" type="ORF">BWLFYP14_01247</name>
        <name evidence="12" type="ORF">ERS852478_00865</name>
        <name evidence="13" type="ORF">ERS852523_02480</name>
        <name evidence="15" type="ORF">GT712_08015</name>
        <name evidence="14" type="ORF">GT728_01060</name>
    </gene>
    <organism evidence="12 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 17">2789STDY5834863</strain>
            <strain evidence="13 18">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="14 20 21" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 21">BIOML-A1</strain>
            <strain evidence="15 20">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="16 19" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000026">
        <property type="protein sequence ID" value="CUP69288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS89014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706943.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000023_gene1801"/>
    <dbReference type="EnsemblBacteria" id="CUN71566">
        <property type="protein sequence ID" value="CUN71566"/>
        <property type="gene ID" value="ERS852478_00865"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP69288">
        <property type="protein sequence ID" value="CUP69288"/>
        <property type="gene ID" value="ERS852523_02480"/>
    </dbReference>
    <dbReference type="GeneID" id="66492991"/>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="11">
        <location>
            <begin position="8"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-D-glucose 1-phosphate binding" evidence="9">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
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        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
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            <position position="191"/>
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        <ligand>
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        </ligand>
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    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003742"/>
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        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUN71566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUP69288.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZL31820.1"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="MZS89014.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="VUX64127.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="424" mass="46702" checksum="8C436D11BFADEBEA" modified="2016-09-07" version="1">MIKKEMIAMLLAGGQGSRLGVLTEKVAKPAVAFGGKYRIIDFPLSNCINSGIDTVGVLTQYQPLRLNTHIGIGIPWDLDRNEGGVTVLPPYEKSTSSEWYTGTANAIFQNMDYMEQYNPDYVLILSGDHIYKMDYEVMLDFHKANKADVTIACMPVPIEEASRFGIMVTDDIGRITEFEEKPEHPSSNLASMGIYIFSWPALKEALMSLKDQNSCDFGKHVLPYCKEKGERLFAYEYNGYWKDVGTLGSYWEANMELIDIIPEFNLYEEFWKIYTKGDIIPPQYISADAVTDRCLIGEGAEIYGEIHNSVIGPNVVIGKGSVIRDSIIMRNSTIGEGVQMDKAIIAEDVTIGNNVVLGCGEEAPNVLKPAVYAFGIATVGERSVIPDNVRIGKNTAISGITVPEDYPDGELAGGQVITAKDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z8V8</accession>
    <name>A0A173Z8V8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dnaC_1</name>
        <name evidence="6" type="synonym">dnaC_3</name>
        <name evidence="6" type="ORF">BWLFYP14_01250</name>
        <name evidence="2" type="ORF">ERS852478_00868</name>
        <name evidence="3" type="ORF">ERS852523_02477</name>
        <name evidence="5" type="ORF">GT712_08030</name>
        <name evidence="4" type="ORF">GT728_01075</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CUN71625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000026">
        <property type="protein sequence ID" value="CUP69232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS89017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64133.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_008706949.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
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        <property type="protein sequence ID" value="CUN71625"/>
        <property type="gene ID" value="ERS852478_00868"/>
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        <property type="protein sequence ID" value="CUP69232"/>
        <property type="gene ID" value="ERS852523_02477"/>
    </dbReference>
    <dbReference type="GeneID" id="66492994"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="182"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN71625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP69232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL31823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX64133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="327" mass="37807" checksum="A7C6CDA3FA3AED37" modified="2016-09-07" version="1">MPLQNYQYDTIMREYSKTQSQNRRILEERTQEIYKKIPRIHEIDEEVATLSAKKARALLSGESSGLEDLKAAISLLSQERNALLVCNSYPEDYLELPYKCPVCQDTGYVGSQKCTCFKKAEIELLYTQSNLKEILKKENFDHFSFDYYSDTMKNEATGLTERETARRAYDIARGFVRNFDSSFENLFLYGDTGVGKTFLSHCIAHDLLESAHCVMYFSAFDLFELLADSKFSRDKTEGQEFVFDSDLLIIDDLGTELTNSFVSSQLFLCINERIMRRKSTIISTNLKLENFSDTYSERTFSRIASNYRMVKLEGKDIRIQKIFLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZD98</accession>
    <name>A0A173ZD98_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199851.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73649">
        <property type="protein sequence ID" value="CUN73649"/>
        <property type="gene ID" value="ERS852478_00936"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN73649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="413" mass="46001" checksum="F19ED590F8EF7C3A" modified="2016-09-07" version="1">MLMKMIADLHIHSRFSMATSKEGTPENLDFWARKKGISLIGTGDFTHPVWREELKERLVSEGNGLYRLRDEYVKEESRKFPGEGTRFVVSGEISSIYKKNGKTRKVHNVILLPGLEAADAMAQRLEKIGNIHSDGRPILGLDSHDLLEMMLDVCPEGILIPAHIWTPHFSVLGAKSGFDSVEECFEELAPYIHALETGLSSDPAMNWRISKLDRYQLVSNSDAHSPSKLGREANLLDIDCSYEGLYRAIQTGEGLEGTVEFFPEEGKYHFDGHRKCGVSLSPVEAERLGGICPVCGKKLTMGVDHRVEQLADRAEGFVKKDGKKYESLVPLPEVISTCMGYSAASKKVQGCFEQMIQTLGTEFDILRNVPSEDIKSCAGERIAEGIENVRTGNVKRIPGYDGEYGKIELFDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZHU9</accession>
    <name>A0A173ZHU9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pyrroloquinoline quinone biosynthesis protein PqqE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Lachnospiraceae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75811">
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        <property type="gene ID" value="ERS852478_01002"/>
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    </dbReference>
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        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN75811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="538" mass="61773" checksum="9BF21916C792A38F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZMC9</accession>
    <name>A0A173ZMC9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VTC domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_JAAITO010000060.1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF09359">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN76770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="250" mass="29937" checksum="6E07334CC6F357C0" modified="2016-09-07" version="1">MKKADRKKEHFRNEWKYLISTSEKEVLNLRMKPLMKLDPHAENGGYLIRSLYFDDYWNSAYEEKESGVLMRKKYRIRIYNYSAESIKLERKKKFGSYIYKEDAPLTKDEVQKILSGEYEFLLKSPYNLCREFYTECMSNMMRPRTIVDYEREPWIMDEGTVRITFDTDVRAAVGSYDIFDSTLPALSVLEPGKLIMEVKFTELLPQILRNLLPPQAEEFTAVSKYVLCYEKTRYMNGFEYWYDTQGRMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZVJ1</accession>
    <name>A0A173ZVJ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79649">
        <property type="protein sequence ID" value="CUN79649"/>
        <property type="gene ID" value="ERS852478_01087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN79649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="51" mass="5910" checksum="B8C26C645F4A602A" modified="2016-09-07" version="1">MREKTYHLYLNEEERSRVIQSLIELKNNLAAQGRYTDAGAISEFPENPPCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZVY6</accession>
    <name>A0A173ZVY6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF2500)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052515.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79799">
        <property type="protein sequence ID" value="CUN79799"/>
        <property type="gene ID" value="ERS852478_01091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019635">
        <property type="entry name" value="DUF2500"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10694">
        <property type="entry name" value="DUF2500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN79799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="122" mass="13574" checksum="0437158A243D00EA" modified="2016-09-07" version="1">MFDLMSIIVPIIFIIVIGIIVFSLGQGIVTWNRNNQSPRSTVSAVIIAKRENITHHQHANAGDASGAHGFHTTTNTMYYVTFQTESGDRMEFQVSGTEYGMLAEGDTGRLTFQGTRYLAFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZX30</accession>
    <name>A0A173ZX30_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Trk system potassium uptake protein trkG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trkG</name>
        <name evidence="11" type="ORF">ERS852478_01117</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199926.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPC010000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80774">
        <property type="protein sequence ID" value="CUN80774"/>
        <property type="gene ID" value="ERS852478_01117"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004772">
        <property type="entry name" value="TrkH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006247">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006247-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN80774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="479" mass="52759" checksum="287AC710CCB2E898" modified="2016-09-07" version="1">MNYSIIIYIIGMILEIEAVFMALPAITALIYQETSGVAFLITIALCLVIGLPLTRKKPTRKAFYTKEGFVTVALSWIVLSIIGAIPFVISRSIPNPVDALFETVSGFTTTGASILSDVEALPHCMLMWRSFTHWIGGMGVLVFILSLLPLTGGYHMNLMKAESPGPSVSKLAPKVQSTAKILYSIYFVMTVIQILLLLVGGMPLFDSICTAFGTAGTGGFGIKNDSMASYSTYLQVVITVFMILFGVNFNAYFFIITKKFAQAFKMEEVRYYFGIIGIAILIITCNIYHIFGSAAKAFQQAAFQVGSIITTTGYATTDFNTWPEISRTILVLLMFIGACAGSTGGGIKVSRILILCKTVRKELHIFLHPNAVKKIKMDGKAIPHEVVRSTNIFFIVYMLIFSSSIFLIAFDDFNLITNFTAVAATFNNIGPGLELVGPTGNFGMFSWFSKLILTFDMLAGRLEIFPLLILFVRDTWKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A4D8</accession>
    <name>A0A174A4D8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cysteine desulfurase IscS</fullName>
            <ecNumber evidence="7">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nifS</name>
        <name evidence="7" type="synonym">iscS</name>
        <name evidence="11" type="ORF">BWLFYP14_03051</name>
        <name evidence="10" type="ORF">ERS852478_01183</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381065.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83023">
        <property type="protein sequence ID" value="CUN83023"/>
        <property type="gene ID" value="ERS852478_01183"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017772">
        <property type="entry name" value="Cys_deSase_NifS_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03402">
        <property type="entry name" value="FeS_nifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="9">
        <location>
            <begin position="5"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="7">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <note>ligand shared with IscU</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN83023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX66775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="394" mass="43604" checksum="A3166A78FF2356DB" modified="2016-09-07" version="1">MGKMIYLDNAATTKTAPEVVQAMLPYFSEYYGNPSSIYDFAGKSKEAITKGREQIAEVLGAKKEEIYFTAGGSESDNWALKATFEAYKAKGNHIITTKIEHHAILHTCEYLEKRGAKITYVDVDENGIVKLDELEKAITPETILISVMFANNEIGSIQPIKEIGRIAKEHGVLFHTDAVQAFCQVPINVDECNIDMLSSSGHKINGPKGIGFLYIRKGVKIRSFVHGGAQERKRRAGTENVPGIVGYGVAAARANASMKERTDKEIAIRDHLIHRIETEIPYVKVNGDRIKRLPNNVNVSFQFVEGESLLLMLDNYGICASSGSACTSGSLDPSHVLLAIGLPHEIAHGSLRMTLSEETTMEDVDFVVDRLKEIVAHLRSMSPLYEDFMKKQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A4T5</accession>
    <name>A0A174A4T5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Histidinol-phosphatase</fullName>
            <shortName evidence="7">HolPase</shortName>
            <ecNumber evidence="4 7">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852478_01187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4 7"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83173">
        <property type="protein sequence ID" value="CUN83173"/>
        <property type="gene ID" value="ERS852478_01187"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="PTHR21039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="8">
        <location>
            <begin position="8"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN83173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="272" mass="31222" checksum="C59F101D4D31E075" modified="2016-09-07" version="1">MDRQILWDCHMHSSFSADSDTPMEVMIHSAVETGLQGITFTEHLDPDYPVTPDNLDFSLDIPAYKEKLAELSDMYKDKIQVRFGIELGLQMHLGEYFDSLLSQTPFDFVIGSSHLVHGYDPYYPEFFEGRKEFLCYMEYFESILENISAYDGFDVYGHIDYVVRYGPNKNREYSYGRYKDILDEILKKLISMGKGIELNTGGYHYGLGEPNPCTAVIRRYRELGGEIITIGADAHTPDKIACAFDKAASVLEACGFRYYTIFKDRKPEFISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A781</accession>
    <name>A0A174A781_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 8 11">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">pgk</name>
        <name evidence="13" type="ORF">ERS852478_01189</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 11">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 11">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 8 11"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199949.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83248">
        <property type="protein sequence ID" value="CUN83248"/>
        <property type="gene ID" value="ERS852478_01189"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8 9">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 9">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <begin position="353"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN83248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="397" mass="42288" checksum="0C19B9B92E4D4C47" modified="2016-09-07" version="1">MLNKKSVDDINVKGKKVLVRCDFNVPLQDGKITDENRLVAALPTIKKLIADGGKVILCSHLGKPKGEPKPELSLAPVAKRLSELLGQEVKFAADPEVVGPNAKAAVAEMKDGDVILLENTRYRAEETKNGDEFSKELASLCDVFVNDAFGTAHRAHCSNVGVTKYVDTAVVGYLMQKEIDFLGNAVNNPERPFVAILGGAKVSSKISVINNLLDKVDTLIIGGGMSYTFSKAMGGHIGTSLCEDDYLQYALDMMKKAEEKGVKLLLPVDNRIGDSFSNDCNIQVVKRGEIPDGWEGMDIGPETEKLFADAVKDAKTVVWNGPMGCFEMPNFAHGTEAVAKALAETDATTIIGGGDSAAAVNILGYGDKMTHISTGGGASLEFLEGKELPGVAAANDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AB11</accession>
    <name>A0A174AB11_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">regX3_4</name>
        <name evidence="11" type="ORF">ERS852478_01231</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN85842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006857257.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000068.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN85842">
        <property type="protein sequence ID" value="CUN85842"/>
        <property type="gene ID" value="ERS852478_01231"/>
    </dbReference>
    <dbReference type="GeneID" id="61431739"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="130"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="130"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN85842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="233" mass="26392" checksum="007889EF02EF77E6" modified="2016-09-07" version="1">MENRILLLEDDVSLIDGLQYSLKKNGFDVDFVRSVQETLTYLSEIEKYDMLILDVTLPDGTGFEICEKVRKNGSQIPIIFLTASDEEVSIIRGLDCGGDDYITKPFKLGELCSRIRALLRRAGLSTQGTGAVMECGDIKIDLLGSRVLLKGKILELTAAEYRLICLLVKNANRIITRDIILDELWDSTGDYVDNNTLSVYVRRLREKIETDPSHPEHLLTVRGFGYQWKEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AHS7</accession>
    <name>A0A174AHS7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87230">
        <property type="protein sequence ID" value="CUN87230"/>
        <property type="gene ID" value="ERS852478_01268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN87230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="30" mass="3367" checksum="ED8FE6F0DBD38293" modified="2016-09-07" version="1">MDAKTIIAIVLVVFIVGAAVWLNIRNRKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AK19</accession>
    <name>A0A174AK19_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_01627</name>
        <name evidence="2" type="ORF">ERS852478_01285</name>
        <name evidence="3" type="ORF">ERS852523_00877</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000007">
        <property type="protein sequence ID" value="CUP20396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87838">
        <property type="protein sequence ID" value="CUN87838"/>
        <property type="gene ID" value="ERS852478_01285"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20396">
        <property type="protein sequence ID" value="CUP20396"/>
        <property type="gene ID" value="ERS852523_00877"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZG6F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN87838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP20396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="34" mass="3680" checksum="A2DC1C490823F861" modified="2016-09-07" version="1">MGMFNPKNRKVITAIIAIILVLAMVVPTVLSLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AWA7</accession>
    <name>A0A174AWA7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclease sbcCD subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sbcD_1</name>
        <name evidence="4" type="ORF">ERS852478_01400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN92882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200058.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN92882">
        <property type="protein sequence ID" value="CUN92882"/>
        <property type="gene ID" value="ERS852478_01400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="586"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="699"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="868"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1023"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN92882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1275" mass="144519" checksum="B5F17365D9E53552" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B0Y7</accession>
    <name>A0A174B0Y7_9FIRM</name>
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        <submittedName>
            <fullName evidence="2">YopX protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93430">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01671">
        <property type="entry name" value="phage_TIGR01671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YopX" evidence="1">
        <location>
            <begin position="43"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN93430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="164" mass="18688" checksum="4EB40B68472A818D" modified="2016-09-07" version="1">MVELMREILFKGKKKDNGEWIEGYLMDGGMPGEKRIFIGKLVIGKWTVMADEFDEVDPDTICEYTGLTDKNGKKIWENDILMCHGNSEDLVKTVFGEFGVRNIETGSIVDKVVGWHYEIIPTDTISRCEPFCYSMPLTKDYIDRCEMEVVGSIFDNPELVQGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B1Q6</accession>
    <name>A0A174B1Q6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
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            <taxon>Firmicutes</taxon>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200089.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94159">
        <property type="protein sequence ID" value="CUN94159"/>
        <property type="gene ID" value="ERS852478_01442"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN94159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="119" mass="12553" checksum="5095CA06C6049291" modified="2016-09-07" version="1">MTPAEAAEAVKVQVQTDKERIEQQVIARYPRASNALRNAALSVLANPSPSAPGSPPGVRSGNLRRNWNMSGGAVCITSGMGYAGYLEHGTSKMAARPFVDKIQQTALPNIMAIFAEIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B2V1</accession>
    <name>A0A174B2V1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200083.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93975">
        <property type="protein sequence ID" value="CUN93975"/>
        <property type="gene ID" value="ERS852478_01436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN93975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="404" mass="44540" checksum="717DE8A448273302" modified="2016-09-07" version="1">MATKLEDLHIKKVDFVDQGANQMANIKIKKSKDGEEIPNPEIGLFKRFVNWITGELSKPGSEITKSATTFNEQINAVSMDAIRDEIWSTCYALQNSLNSILCDAEMDSSAKQAAMETSTEQFAEAMKGYIPNWASGTATNIRKNLTTPDETDLQMVMKAHKNLTDIIEKSNEDNEKGELEDMLKINKSKMTAEERAAYEELIKKYAVETEEQTEEPVGKSAPKVEDPDIVDDSEVTKTQKSVTPPPAAPTTETSADTGDDIYKGLHPAVRARLEALEKRAAEAEERELLDVAKKYEIVGEKPEELVKTLKSLKDAGGTAYNDMISVLDRSVAMVEQSGVFSEIGKSFSGNPVASIKKSAAESKIDTIAKGYMEKDSALTYNAALAKAWEDHPELLDEYEAEAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B7K8</accession>
    <name>A0A174B7K8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993854.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000124.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96817">
        <property type="protein sequence ID" value="CUN96817"/>
        <property type="gene ID" value="ERS852478_01517"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN96817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="241" mass="28417" checksum="F55EF5D27A766C5E" modified="2016-09-07" version="1">MGNEAGEWIIHGVTWDDPKCIHDVDEAVEYINRVGFLPLFKNEIPGFSLEERTVAEYWWSDDPVRDPWRWRIAIAKRHDVLYGKFFAKKAGFISKKWLPVFANYRRDGYDFDALFEDEKAPIKHKNIMDHFMENDAEIYSYELKKLAGFGKDGEKGFDGAITSLMMQTYLCNCDFRKRINQKGVEYGWDVAVYSSPEHIYGYDHVTSCYKEDPRTSWGKIVDYMKQLYPEAKDMQIRKILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B9W6</accession>
    <name>A0A174B9W6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maff2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002566673.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97253">
        <property type="protein sequence ID" value="CUN97253"/>
        <property type="gene ID" value="ERS852478_01528"/>
    </dbReference>
    <dbReference type="GeneID" id="61861945"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024272">
        <property type="entry name" value="MAFF-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12750">
        <property type="entry name" value="Maff2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN97253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="71" mass="7060" checksum="3EDA15B29842E150" modified="2016-09-07" version="1">MEFFNSAVDTLQTIVVGLGGALCVWGGVNLLEGYGADNPASKSQGIKQLVAGGGVALIGMTLVPLLSGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BVR4</accession>
    <name>A0A174BVR4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Site-specific tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_01704</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO04894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009247527.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO04894">
        <property type="protein sequence ID" value="CUO04894"/>
        <property type="gene ID" value="ERS852478_01704"/>
    </dbReference>
    <dbReference type="GeneID" id="61850128"/>
    <dbReference type="GeneID" id="66882338"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028259">
        <property type="entry name" value="AP2-like_int_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14657">
        <property type="entry name" value="Arm-DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="7">
        <location>
            <begin position="56"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="166"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO04894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="363" mass="42965" checksum="63042B99C43CE726" modified="2016-09-07" version="1">MPVFKNEDNGTWYVMARYVNWKGERKQKCKRGFATKREAQEWERMFKLQTSSDLDMSFEAFTELYINDVKNRLKENTWLTKEHIIRTKILPYFGKLKISEISTKEIITWQNEMLAYRDEKKKPYSQTYLKTLHNQLSAIFNHAVRYYELRSNPAAKVGNMGREEHKEMLFWTKEEYKKFSFEMMDKPVSFYAFEMLYWCGIREGELLALTPADFNFDKETVTINKSYQRLKGQDVITSPKTKKSNRTIKMPKFLCEEMKEYLGMLYGLKKKDRIFTVTKSYLHHEMDRGAKAAGVKRIRIHDLRHSHISLLIDMGFSAVAIADRVGHESIDITYQYAHLFPSKQIEMAEKLDDLGKGDFENVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BW53</accession>
    <name>A0A174BW53_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multiple sugar-binding periplasmic protein sbpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sbpA_2</name>
        <name evidence="4" type="ORF">ERS852478_01690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03746">
        <property type="protein sequence ID" value="CUO03746"/>
        <property type="gene ID" value="ERS852478_01690"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018722" evidence="2">
        <location>
            <begin position="28"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="115"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO03746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="510" mass="55508" checksum="C26610101999EE1E" modified="2016-09-07" version="1">MKRRATAILLGIMVSSMFLSACGKNEAKEAANESAQVEEEGVGEVTEEGEKVEAENKNASDADDSSKAGDSAKSDEDNKEISVKEEEDGDSSGKDLDDESEEDAEVTEASAGKIGVLLSDDDEDAKIDSEEMTSQIEDGGYEADVKNAGGDPALQISQIQEFIDEQVSALIIDPVDSYGLTDILKTANEQEIPVISYDSLIRDTADINYYATYDTRSIGNDIAKEIIKKMDLDKAREDKKSYTIEFLMGSPDDNAALFLCNGIQEGLQEYLDDGTLVCKSGNTSFDDTGIMRWSETSAKTKLDSIISEFYAEEKAPDIICTAYDGFAYAAEEILSDSGLEPGSDEWPMITGYGSEAQAVKDIAAGKMSFTMFMDRKELAKGGAQMAIDYLTGEKVDVKDYSQYDNGVKIVGTFTCGAQMIDKDNYQILVDNGTYTEDEIAPDPTPTPEVTPAQEATPVPKVTLKTASEEDSKEVTPTPETEDKSEGETRENLIYDSEDNSKVEKTSDQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BZ83</accession>
    <name>A0A174BZ83_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Replicative DNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO04838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200169.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO04838">
        <property type="protein sequence ID" value="CUO04838"/>
        <property type="gene ID" value="ERS852478_01702"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO04838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="384" mass="43726" checksum="923BCEB4EFE9D890" modified="2016-09-07" version="1">MENKKEMTIPNVSAATDAEQSLSKCTDNSIVNQDTDFKGYEQSFEEMQREILRQLDPSYLKTVSMTTLYDTVFEVQTPLIDGLLQRGTYLFVGSPKVGKSFMMAQLAYHISTGTPLWEYKVRKATVLYFALEDDYPRLQKRLFQMFGAKETGNLYFATECKTVNGGLEEQIRGFMREHPDTGLIIIDTLKRVREAGGADYSYASDYDVVARLKALADSYKVSMLIVHHTRKQKSEDIFDMISGTNGLMGAADGAFVLSKDKRASNNATLDVAGRDQQDMKIHLVRDSERLVWNFAKSETEMWKEPPEPLLEKIADTLFSESDRWEGTASELCERLAVDIKPNVLSLRLSINASRLFRDYGIRYQNSRTHDGRKVSLWKETEQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C3C1</accession>
    <name>A0A174C3C1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">sn-glycerol-3-phosphate transport system permease protein ugpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ugpA_5</name>
        <name evidence="7" type="ORF">ERS852478_01762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200238.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06779">
        <property type="protein sequence ID" value="CUO06779"/>
        <property type="gene ID" value="ERS852478_01762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO06779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="312" mass="35030" checksum="DA4BE14311A26950" modified="2016-09-07" version="1">MTDLAKVQKKKRKINVAGYLFILPAMLFFCLYILYPIFFIVKNSLLKWATLSNMEFVGLENFIKVFQDSTFWVTMKNSILWIVVTVPVQAILGFFLAYAIEERIKSKKADGKAFSRTFYRTLFFIPVVTSVTVVAIMFSKIFQPYQGIIGHYLNSWFGMSPTINVLGNSKAALWGIMLANIWEWTGWSMIMYIGGISQISEDVKEAARIDGANTWQEIIYVYIPALGSVHKSLLMLGIIGSLQTYALIGVMTGGGPNHATEMPGTYIFMKGFTESQMGYACAISVAVLIFALVLTFIQVRFLGSGDFMKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C4K0</accession>
    <name>A0A174C4K0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltose-binding periplasmic proteins/domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200240.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06810">
        <property type="protein sequence ID" value="CUO06810"/>
        <property type="gene ID" value="ERS852478_01763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018913" evidence="1">
        <location>
            <begin position="28"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO06810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="435" mass="47857" checksum="E7246F1A79196CA5" modified="2016-09-07" version="1">MKNKKLMSILLVSAILGTTLGTTAVSAADETSVSLWTWSPITRTAEKMIDAFEKANPDITIDYTNYNYNPEYLQALSAASASDNLADIVGLQPGSLTQTYSDYLIDLSDYAKAEWGDDWTSVYDNVTQSQLQLGNKDGDDGHYILPIETQDIYVEYNKTLFEQLGLKVPTTYDELVEVSKTLRDNGYAPLFFGGADGWQHVNLLLMCTSQISDTLFDECQNGEKAWTCDEMKQAMTNYKKLFDDGVMQDGSLSSTSYSDGTTLFLAGQAGMMLLGSWWAQEYTSEDVSDAVANWDYDYFYLPALEEGLSDSKAIGGVDFGYGITKNCENPDLAWKALVSFATGEGAQEIANDMNNHLSYPNIEPDTSAMVERDGLQNVVDEFNRSGKDIAAGLVNQRIAEPTIETAIQEAMQGLIGGTYSVDEATQHIQDAQDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CLW7</accession>
    <name>A0A174CLW7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na+/alanine symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852478_01932</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200449.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12900">
        <property type="protein sequence ID" value="CUO12900"/>
        <property type="gene ID" value="ERS852478_01932"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00835">
        <property type="entry name" value="agcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO12900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="471" mass="50446" checksum="15A133186230292D" modified="2016-09-07" version="1">MWEAINSFLTTVDNLVWGVPLMVLIMAGGILLTARLGLLQIRRLPLALKWMFKNEEEGDGEISSFAALCTALSATIGTGNIVGVATAVCAGGPGALFWMILAAFFGMATKFSEGLLAVKYRVVAEDGHSLGGPFYYIEKGMGTKWKWLAKIFAFFGVCVGLFGIGTFSQVNGISSAVQNFFDPNKSNCVNIPFLGEYSWAVVISSLILAACVAAILIGGLKRIATVSQIIVPFMAVIYLIFSVALILLNITEIPAAIVTVVKGAFNPSAVTGGVVGTMIVSMQKGVARGIFSNEAGLGSAPIAAAAAQTKEPVRQGLVSMTGTFIDTIVICTMTGLSIVLTGAWQVEGLEGVQVTTYAFQHGLPIPGQVSAFVLMICLVFFAFTTILGWDYYSERCLEYLTNGHKKTILTYRWLYILAVFIGPYMTVSAVWTIADIFNGLMAIPNMIALFALSGVIVKETKTFFAAEKHKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CTI2</accession>
    <name>A0A174CTI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDP-diacylglycerol-serine O-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200471.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15065">
        <property type="protein sequence ID" value="CUO15065"/>
        <property type="gene ID" value="ERS852478_01979"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO15065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="206" mass="23028" checksum="B7057F99418775EE" modified="2016-09-07" version="1">MFLGIYDYTVILTYISLGISVFGITRALEGDFKVAIFCLALSGLCDMFDGKIARTKKNRTDDEKNFGIQIDSLCDVVCFGIFPAMICYCLGVNTSAGVGALIFYSVASVIRLAYFNVSEAKRQNETSENRQYYQGLPITSMAIILPFLYLMRRYCGLYFLIVIHIAVIIVGLLFILDIKVKKPQNPVRILLVAVVALALAKMFRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CV03</accession>
    <name>A0A174CV03_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200499.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16857">
        <property type="protein sequence ID" value="CUO16857"/>
        <property type="gene ID" value="ERS852478_02035"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032TDR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO16857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="208" mass="23552" checksum="92A8131A8B4DD38E" modified="2016-09-07" version="1">MELISNLFQFAVTLLGFCMSGIRYLKGRKQTYFLLTCFYGCFALGSLYWTLYLLLFSETPQVFYVSEFGWVASVIFLYLLQYTLSSAEERDFSTRKSLIAPLIGVPLCVFYCTFGDVLSNLLWCGMMIVVSYHSIRGLAYAQIQTGTACKMRYFHIGVLCYVAVEYALWISGCLWPGYSISAPYCWFDLLLTGCLFALLPATGKAVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D1P1</accession>
    <name>A0A174D1P1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="2">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Alpha-IPM isomerase</fullName>
            <shortName evidence="2">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DmdB_1</name>
        <name evidence="5" type="synonym">DmdB_2</name>
        <name evidence="2" type="synonym">leuD</name>
        <name evidence="8" type="ORF">BWLFYP14_02803</name>
        <name evidence="4" type="ORF">ERS852478_02101</name>
        <name evidence="5" type="ORF">ERS852523_01750</name>
        <name evidence="7" type="ORF">GT712_17100</name>
        <name evidence="6" type="ORF">GT728_16280</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">2789STDY5834863</strain>
            <strain evidence="5 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 13">BIOML-A1</strain>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LeuD family. LeuD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000015">
        <property type="protein sequence ID" value="CUP47892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000049">
        <property type="protein sequence ID" value="MZL34707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000048">
        <property type="protein sequence ID" value="MZS90728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380260.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000130_gene183"/>
    <dbReference type="EnsemblBacteria" id="CUO19581">
        <property type="protein sequence ID" value="CUO19581"/>
        <property type="gene ID" value="ERS852478_02101"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP47892">
        <property type="protein sequence ID" value="CUP47892"/>
        <property type="gene ID" value="ERS852523_01750"/>
    </dbReference>
    <dbReference type="GeneID" id="66494805"/>
    <dbReference type="eggNOG" id="COG0066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01032">
        <property type="entry name" value="LeuD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011827">
        <property type="entry name" value="LeuD_type2/HacB/DmdB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02087">
        <property type="entry name" value="LEUD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="1 2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="3">
        <location>
            <begin position="51"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO19581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP47892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL34707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS90728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="163" mass="18080" checksum="40BEEAAE0BF6A853" modified="2016-09-07" version="1">MEKFTGKVWVLDDDIDTDIIIPTEYLALKTIDDMKQYGFSPLRPELAGQIQKGDIIVAGKNFGCGSSREQAPEIIKALGIQCVIAKSFARIFFRNSINNGLLLIEQPDLHDDIKEGDEVTVVMNEHVDYNGKQYPIASLPENLMSIIQAGGLVKAMRKLNGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D2V0</accession>
    <name>A0A174D2V0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380257.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19783">
        <property type="protein sequence ID" value="CUO19783"/>
        <property type="gene ID" value="ERS852478_02107"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO19783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="105" mass="11661" checksum="EBE37A96CB72953F" modified="2016-09-07" version="1">MLEKIAAVNIGPGMEFDTSVLTGDVAENWKTMLTEIQLKLIKEDQKFSKKLGQWDYFGEPIGDFNTEYAYRALVALAGLGANTVEVALYPKIEQDADGNTLLNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D697</accession>
    <name>A0A174D697_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmid maintenance system antidote protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmid replication initiation factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005423183.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20993">
        <property type="protein sequence ID" value="CUO20993"/>
        <property type="gene ID" value="ERS852478_02147"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003916">
        <property type="term" value="F:DNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003491">
        <property type="entry name" value="Rep_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040819">
        <property type="entry name" value="Rol_Rep_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02486">
        <property type="entry name" value="Rep_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18106">
        <property type="entry name" value="Rol_Rep_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO20993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="410" mass="48223" checksum="1E6A721BD2D44E4C" modified="2016-09-07" version="1">MSQFFRKGGIALNDTEWIQDFADRRLQYGVSQTKLAVMAGISREHLSRIESGKVAVTEEMKVKLLEALEKFNPEAPLTMLFDYVRIRFPTLDIGHIIKDILQLNIQYMIHEDFGHYSYTEHYYIGDIFVYTSPDEEKGVLLELKGKGCRQFESYLLAQERSWYDFLMDALVDGGVMKRLDLAINDHTGMLDIPELTEKCRNEECVSVFRSFKSYASGELVKHEEQDKAGMGYTLYIGSLKSEVYFCVYEKSYEQYIKLGIPIEEAPIKNRFEIRLKNERAYYAVRDLLTYYDAERTAFSIINRYVRFVDKEADKKRSDWKLSVRWAWFIGENREPLKLTTKPEPYTLDRTLRWIQRQVDPTLKMLETITAKTGIDYLKEIRKSTKLTEKHYKIIEQQTTSTEDVILEKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D952</accession>
    <name>A0A174D952_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="6">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mnmE_2</name>
        <name evidence="6" type="synonym">mnmE</name>
        <name evidence="6" type="synonym">trmE</name>
        <name evidence="9" type="ORF">ERS852478_02182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026649417.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22094">
        <property type="protein sequence ID" value="CUO22094"/>
        <property type="gene ID" value="ERS852478_02182"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="8">
        <location>
            <begin position="220"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="230"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="249"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="274"/>
            <end position="277"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO22094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="457" mass="50963" checksum="ED060DAA0F4984B9" modified="2016-09-07" version="1">METTIAAISTAMSASGIGIIRISGENAMDVISRIYRSKGGKKKIKEVPTHTIHYGYIYDGEELIDEVLVMIMHAPRTFTGEDTVEIDCHGGVYAMQRVLDTVLKNGAEIAEPGEFTKRAFLNGRMDLSQAEAVMDVIQAKNEYALRSSMDQLRGSVQKAIRDIREKLIYHIAYIESALDDPEHISLDGYPQELLEVVDNEQKEVKRLLKTSSDGKMIQEGIQTVILGKPNAGKSSLLNLLIGENRAIVTDIAGTTRDILEEYITLHGISLKIIDTAGIRETKDIVEKIGVDRAREMAQKADLILYVVDSSVPLDENDEEIMEMLTGKKAIILYNKTDLQPEIQPEILEEKTGHPVIPISAKEEKGITELEEQIKDMFFGGEISFNDEVYITNARHKAALEEADRSLDLVRNSIEMGMPEDFFSIDLMNAYENLGKILGESVGEDLVNEIFSKFCMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DE08</accession>
    <name>A0A174DE08_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">dnaA</name>
        <name evidence="18" type="ORF">BWLFYP14_02849</name>
        <name evidence="14" type="ORF">ERS852478_02188</name>
        <name evidence="15" type="ORF">ERS852523_01710</name>
        <name evidence="17" type="ORF">GT712_11380</name>
        <name evidence="16" type="ORF">GT728_11220</name>
    </gene>
    <organism evidence="14 19">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 19 20" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 19">2789STDY5834863</strain>
            <strain evidence="15 20">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="16 22 23" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 23">BIOML-A1</strain>
            <strain evidence="17 22">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="18 21" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000015">
        <property type="protein sequence ID" value="CUP46768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000025">
        <property type="protein sequence ID" value="MZL33752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708003.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000021_gene1696"/>
    <dbReference type="EnsemblBacteria" id="CUO22290">
        <property type="protein sequence ID" value="CUO22290"/>
        <property type="gene ID" value="ERS852478_02188"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP46768">
        <property type="protein sequence ID" value="CUP46768"/>
        <property type="gene ID" value="ERS852523_01710"/>
    </dbReference>
    <dbReference type="GeneID" id="66493380"/>
    <dbReference type="eggNOG" id="COG0593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="142"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="13">
        <location>
            <begin position="357"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="150"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO22290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUP46768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZL33752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MZS89657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VUX66474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="451" mass="51444" checksum="F2FB128CBA6A497E" modified="2016-09-07" version="1">MNKVVEKWDEILQIVKTEHDLSDVSFNTWLKPLTVYEVVDNVVTIIVPSEQVGLNYISKKYKLPLQVTISEVTGMENCDINFILPEDVPKKEEVSPKAQSQDARCEEAHLNPKYTFDTFVVGSNNKFAQAAALAVAESPGDTYNPLFIYGGAGLGKTHLMHSIAHFIIDHDENSKVLYVTSEEFTNELIETIRNGNNSAMTKFREKYRNIDVLLVDDIQFIIGKESTQEEFFHTFNSLHSAKKQIIISSDKPPKDMEILEERFRSRFEWGLIADITLPDYETRMAILHKKEEMDGYDINEEVIKYIANNIKSNIRELEGAINKVMAFAKLEKKEVTLELAEQALKDIISPDEKKVITPDYIISMVAEHFDVTVDDLCGNKRNSKIVTPRQIAMYLCREIISTPLKSIGKCLGNRDHTTIMHGIDKIEKEINNDENLKNTIETLKKKINPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DE77</accession>
    <name>A0A174DE77_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">radA</name>
        <name evidence="9" type="ORF">BWLFYP14_01471</name>
        <name evidence="8" type="ORF">ERS852478_02219</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO23794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705472.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23794">
        <property type="protein sequence ID" value="CUO23794"/>
        <property type="gene ID" value="ERS852478_02219"/>
    </dbReference>
    <dbReference type="GeneID" id="66495138"/>
    <dbReference type="eggNOG" id="COG1066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01121">
        <property type="entry name" value="Sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="69"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="354"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="98"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO23794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX64618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="458" mass="49989" checksum="8D9CC977339813DD" modified="2016-09-07" version="1">MLKNKKTVYFCQECGYESAKWMGQCPGCKSWNTFVEETVSTKKPSSSGVMKSSEKRQEPVILKDISLSEDERQTTQIGELDRVLGGGIVPGSLVLVGGDPGIGKSTLLLQVCRNLAEKQVSVLYISGEESLRQIKLRANRIGQFTDKMQLLCETNLEVIREVIERRKPDVVVIDSIQTMFHEDVSSAPGSVSQVRESTNILMQIAKGMGVSIFIVGHVTKEGNVAGPRVLEHMVDTVLYFEGDRHASYRILRAVKNRFGSTNEIGVFEMCNTGLEEVKNPSEYMLNGRPEDASGSVVACSMEGTRPILVEIQALVCQSNFGIPRRTAVGTDFNRVNLLMAVLEKKVGLRLAASDAYVNIAGGMKMTEPAIDLGICLAIVSSAKDIVIPDNVMVFGEVGLSGEIRAVNMAGQRVQEAKKLGFGTVVLPEVCRSSVGKVEGINLVYVSQIRDAIGYIMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DJ87</accession>
    <name>A0A174DJ87_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_01482</name>
        <name evidence="2" type="ORF">ERS852478_02229</name>
        <name evidence="3" type="ORF">ERS852523_02426</name>
        <name evidence="5" type="ORF">GT712_11645</name>
        <name evidence="4" type="ORF">GT728_09350</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000025">
        <property type="protein sequence ID" value="CUP67844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000018">
        <property type="protein sequence ID" value="MZL33398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000022">
        <property type="protein sequence ID" value="MZS89708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705486.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000042_gene3027"/>
    <dbReference type="EnsemblBacteria" id="CUO24086">
        <property type="protein sequence ID" value="CUO24086"/>
        <property type="gene ID" value="ERS852478_02229"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP67844">
        <property type="protein sequence ID" value="CUP67844"/>
        <property type="gene ID" value="ERS852523_02426"/>
    </dbReference>
    <dbReference type="GeneID" id="66493790"/>
    <dbReference type="eggNOG" id="ENOG50338GS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046140">
        <property type="entry name" value="DUF6142"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19639">
        <property type="entry name" value="DUF6142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO24086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP67844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX64629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="106" mass="11405" checksum="8F01383027D9E126" modified="2016-09-07" version="1">MAKRYRYAFAKKREAQQGKLSAVLAAVSLVLFVTAVLLAFFLQGQYGYIVGGISLCAMLLSVYGFAMGLKSFSEENRTHKAGMIGSIANGIIMIGWLGIFLMGISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DLB8</accession>
    <name>A0A174DLB8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021651359.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000264.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24680">
        <property type="protein sequence ID" value="CUO24680"/>
        <property type="gene ID" value="ERS852478_02252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO24680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="102" mass="11330" checksum="AA9308382DC7C73B" modified="2016-09-07" version="1">MLGFSIMMWFVSAILIFVSISLLKGNYSFVHGKVFDTTDNKKEYAKELGKPVLFVGIGILVSGVIAIIVKNHSIPTAVFFLAIIAGIAGLWLHKIQKNFRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DMZ5</accession>
    <name>A0A174DMZ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sorbitol dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gutB_2</name>
        <name evidence="5" type="ORF">ERS852478_02319</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.14" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993375.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26824">
        <property type="protein sequence ID" value="CUO26824"/>
        <property type="gene ID" value="ERS852478_02319"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="66"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="230"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO26824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="407" mass="44017" checksum="DB19E30D83F13199" modified="2016-09-07" version="1">MDMNNVNIEEIVKQVLSGMTGNAPAAATVSAPAATTGIPKTARVAVLTEKEHFELKEYPIPPIGDDDILVKVEGCGVCGTDAHEFKRDPFGLIPVALGHEGTGEIVAMGKNVKVDTAGKPVKVGDKVVTCMIFKDDPEITMFDLNKKNVGGADVYGLLPDDDVHLNGWFSDYIFLRGGNFGTTFFNVSDLDLDSRILIEPCAVLVHAVERAKTTGILRFNSRVVVQGCGPIGLICIAVLRTMGVEHICAVDGNEKRLEFAKRMGADTSVNFMNFKGIEALTEAVKEAQGGHLADFAFQCTGNPKAHANIYKFIRNGGGLCELGFFINGGDATINPHFDLCSKEINLVGSWVYTLRDYVTTFDFLKRANAIGLPMSELITDKFPLEQINEALQTNLAMTGLKIAVVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DQ05</accession>
    <name>A0A174DQ05_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26185">
        <property type="protein sequence ID" value="CUO26185"/>
        <property type="gene ID" value="ERS852478_02298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO26185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="42" mass="4942" checksum="23DAC92D729B0BED" modified="2016-09-07" version="1">MFGDSIVICVFWGRRNERGSLRGIIYKKNYIKNVYLKGGNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DS89</accession>
    <name>A0A174DS89_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-hydroxyphenylacetate decarboxylase large subunit</fullName>
            <ecNumber evidence="5">4.1.1.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">csdB</name>
        <name evidence="5" type="ORF">ERS852478_02323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.83" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380435.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26955">
        <property type="protein sequence ID" value="CUO26955"/>
        <property type="gene ID" value="ERS852478_02323"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043722">
        <property type="term" value="F:4-hydroxyphenylacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 2" id="KW-0556">Organic radical</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PFL" evidence="4">
        <location>
            <begin position="13"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="3">
        <location>
            <begin position="721"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="2">
        <location>
            <position position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO26955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="841" mass="93784" checksum="A002BB00BFE47E68" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DUS1</accession>
    <name>A0A174DUS1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acpP_2</name>
        <name evidence="1 7" type="synonym">acpP</name>
        <name evidence="9" type="synonym">acpP_1</name>
        <name evidence="9" type="ORF">BWLFYP14_00167</name>
        <name evidence="5" type="ORF">ERS852478_02368</name>
        <name evidence="6" type="ORF">ERS852523_02031</name>
        <name evidence="8" type="ORF">GT712_04640</name>
        <name evidence="7" type="ORF">GT728_02200</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000019">
        <property type="protein sequence ID" value="CUP56145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL32045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993747.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1097"/>
    <dbReference type="EnsemblBacteria" id="CUO28977">
        <property type="protein sequence ID" value="CUO28977"/>
        <property type="gene ID" value="ERS852478_02368"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP56145">
        <property type="protein sequence ID" value="CUP56145"/>
        <property type="gene ID" value="ERS852523_02031"/>
    </dbReference>
    <dbReference type="GeneID" id="66494256"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 2 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1 2">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO28977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP56145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL32045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS88399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="75" mass="8359" checksum="11A6D8F8526D0BE7" modified="2016-09-07" version="1">MELEKIKAIIAEVLNIDADSITEDTTFVDDLGADSLDIFQIIMGIEEEYDIELDNESVEQIQTVGDAVEAIRTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DVG0</accession>
    <name>A0A174DVG0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200740.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29424">
        <property type="protein sequence ID" value="CUO29424"/>
        <property type="gene ID" value="ERS852478_02382"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="2">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO29424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="137" mass="15624" checksum="01C806A08CBB2F83" modified="2016-09-07" version="1">MKRIKVLGSVLKRTRADKIIISFIVFIFAIAAVIQLAEPDINRYGDALWYCYAVISTAGFGDVVAVTFIGKMCSVLLTIYSLFVVAIATGVVVNFYTQMVEMQRKETLAMFMDQLERLPELSREELENISRKVRQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DX82</accession>
    <name>A0A174DX82_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ftsY</name>
        <name evidence="7" type="ORF">ERS852478_02365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200711.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28869">
        <property type="protein sequence ID" value="CUO28869"/>
        <property type="gene ID" value="ERS852478_02365"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="6">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="113"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="259"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO28869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="318" mass="34659" checksum="DAE9065979322D65" modified="2016-09-07" version="1">MAEEKKGFFKRLVSGLAKTRDNIVAGFDSIFSGFSSIDEDFYEELEEILIMGDIGINATTSIIENLKKEVSERHIKEPMECKQLLINEIKDQMRVDSTEYEFENRRSVVLVIGVNGVGKTTSVGKLAGKLKDQGKKVILAAADTFRAAAGEQLTEWANRAGVEIIGGQAGADPASVIYDAVAAAKARNADVLLCDTAGRLHNKKNLMEELRKIYKILEREYPDAYLETLVVLDGTTGQNALAQARQFAEVANVSGIILTKLDGTAKGGIAVAIQSELDIPVKYIGVGESIDDLQKFDADAFVNALFDVDHKENPDAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E046</accession>
    <name>A0A174E046_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_00141</name>
        <name evidence="3" type="ORF">ERS852478_02395</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29836">
        <property type="protein sequence ID" value="CUO29836"/>
        <property type="gene ID" value="ERS852478_02395"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033M7I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO29836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="115" mass="13513" checksum="AA2EA702E1888140" modified="2016-09-07" version="1">MDCQTAEGMVSRYIKHDLPLNELEEFLDHVQNCSSCYDELETYFIVHEVTHQLDDDSSDSVLDFKKLLEQDIRKSRRYIRKKKVSWLMFGVSICLLIATIAAILIFVMMETNYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E0D5</accession>
    <name>A0A174E0D5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycerophosphoryl diester phosphodiesterase</fullName>
            <ecNumber evidence="4">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ugpQ_1</name>
        <name evidence="4" type="ORF">ERS852478_02399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.46" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200748.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29936">
        <property type="protein sequence ID" value="CUO29936"/>
        <property type="gene ID" value="ERS852478_02399"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="3">
        <location>
            <begin position="257"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO29936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="493" mass="55582" checksum="9E774A44CCD1E863" modified="2016-09-07" version="1">MGDKKKEYRDKRTGMQTVRSAIFAIVLIITGFISIIYVADNTYAADEYRVHKSEVVVKTGATYTVKILNHDTKVSPKKFKWTSSNSKCAKVINGRIYGLKPGQATITAQMSGLKVNCEVFVCNKTETVLFKKYKKQVKVTAGKTVILEPQKYGKRLTYTSSDKTVATVSKKGKVTAKKAGNVKITSVSYGTDRYVSEIEVIVLPAASETPEITPTLTPDEPAPSVTPEPTVTVTPTPKITPAPEDEEKFRKPLDGVTHYILHRGEQTAAPENSVPAFETAGRNGAEFVETDVRETADGVLVVSHDDSLLRMCGEDRFISEMTYEEIKQYPIINGRNASQYPDNLIPTLEQYIACCNKYSVTPVIEIKSIRTEEAMNLFMQLLTESQKEPVLICFRIETLGKLREMGFTGKMQWIRTVRMNASMIQQCKKYDLDISAEYKNISMNDINNAHQNGIRISVWLCRNEDMVDIFRKMGADYITYERWNTDEVKIRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E0W3</accession>
    <name>A0A174E0W3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_00099</name>
        <name evidence="1" type="ORF">ERS852478_02437</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO31107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31107">
        <property type="protein sequence ID" value="CUO31107"/>
        <property type="gene ID" value="ERS852478_02437"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZRZQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO31107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX66546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="83" mass="9607" checksum="E013769E0D4E35D8" modified="2016-09-07" version="1">MLISVYYSNPVCQLSQVESSANYGYLTDYYYNAGNLYKQRLSVILLRFTVTVHIPLSREVFWHEYAKIPRHTSQNSIAAGNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E3G2</accession>
    <name>A0A174E3G2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02158</name>
        <name evidence="2" type="ORF">ERS852478_02462</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993993.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32321">
        <property type="protein sequence ID" value="CUO32321"/>
        <property type="gene ID" value="ERS852478_02462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252830" evidence="1">
        <location>
            <begin position="27"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO32321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="365" mass="41198" checksum="2FEDFA5463508C48" modified="2016-09-07" version="1">MVKKVLLCFMLGVATISSGCGKQVSSEKSNVVDMLESDDSKVKDTFPDTYNAESESGKVKFNCTLELPENMNTRTIQKTTVEGVHSYDKDKAYSLLAEGKEISNKEQYDGDNGEIISYTFSDGASLYLDYNITWTSATSSLYAYLGVQQSDYIDLFSSDSVSLDKDKYISEIKKDMNELGYDTENLSFQAIPLSVDAMKKLRDQELNNGLLEKGKTNEPTSEDEAYFIYAYQENTGIPVFHELMSVAKQMSDDSPDNAPVQAIYSARGLESLTIDYIYNFKNEQNTVTLKPFDEIASVVEEKYDNILNDVNYEVTRAKLYERVYTGEDQKYAEEPIWYFEVMENGSNKTVMLVNAETGKEINLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E3P2</accession>
    <name>A0A174E3P2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02155</name>
        <name evidence="4" type="ORF">ERS852478_02465</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703638.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32401">
        <property type="protein sequence ID" value="CUO32401"/>
        <property type="gene ID" value="ERS852478_02465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252691" evidence="3">
        <location>
            <begin position="26"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO32401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="432" mass="46948" checksum="CA28CDA1BA740CE4" modified="2016-09-07" version="1">MRNLFVKTALVLCTTIIFLPATVFATEPQNTEITSAEEGFTDSDPSVSYENDNSLTLDEKEDDSTSTEPPAEDEKTPDKADTDKENPDPDIFTSGDDFGDGSKSNPFHVVIDSDNPEDGDAPQITDPVIDNGGYSGGGGGGNSTSDSSSEKILHKPQVLLEDSNLSGGRLEAGSTTEMSLTFRNKSCSQNVFGLKISLSTENKGIEFEKNSFYVQVLAPGEAITLEQMITITENCDPGQAVITFSLDYEDSKATATTGTELLSFQIIQPVRVKLEASDIPSVLYTMDTVEIPVKAMNLGRDKIYNASVSLKADELSSNDTAFLGTIEAGDLSQGSLRIYVKGKTGKCAGQLILTYEDADGKSYEEEIKFDSEIKETQIKSLKVEDDQEKTNNWWYSIAAVVAVLLISIILILVRKLHKKNILLEEARKAASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EAI6</accession>
    <name>A0A174EAI6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="10">APRT</shortName>
            <ecNumber evidence="5 10">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">apt</name>
        <name evidence="12" type="ORF">ERS852478_02520</name>
        <name evidence="13" type="ORF">ERS852523_03683</name>
        <name evidence="15" type="ORF">GT712_02255</name>
        <name evidence="14" type="ORF">GT728_13330</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">2789STDY5834863</strain>
            <strain evidence="13 17">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="14 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 19">BIOML-A1</strain>
            <strain evidence="15 18">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="5 10"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000060">
        <property type="protein sequence ID" value="CUQ03200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000033">
        <property type="protein sequence ID" value="MZL34158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703730.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000029_gene641"/>
    <dbReference type="EnsemblBacteria" id="CUO33768">
        <property type="protein sequence ID" value="CUO33768"/>
        <property type="gene ID" value="ERS852478_02520"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ03200">
        <property type="protein sequence ID" value="CUQ03200"/>
        <property type="gene ID" value="ERS852523_03683"/>
    </dbReference>
    <dbReference type="GeneID" id="66495271"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="11">
        <location>
            <begin position="34"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO33768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUQ03200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZL34158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZS87944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="174" mass="19085" checksum="4324E61990D3CCA1" modified="2016-09-07" version="1">MKKIEDYVLSIPDFPEPGIIFRDITSVLQDADGLQLAIDSMQDCLKDIDVDVIAGTESRGFIFGVPIAYNLHKPFVPIRKKGKLPRETVSVSYDLEYGSAEIEMHKDSIKPGQKVVIVDDLIATGGTIEAAIKLVEQLGGEVVKVVFLMELAGLKGRERLNGYDVASVICYDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ECI1</accession>
    <name>A0A174ECI1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hisS</name>
        <name evidence="4" type="ORF">ERS852478_02515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33600">
        <property type="protein sequence ID" value="CUO33600"/>
        <property type="gene ID" value="ERS852478_02515"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="3">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO33600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="408" mass="46550" checksum="E9D246524B4C0E68" modified="2016-09-07" version="1">MKDILPKEMEIRNYVMNMIRETYGTFGFSSIETPCVEHIENLSSKQGGENEKLIFKILKRGEKLKLAEAEKESDLVDSGLRYDLTVPLSRYYSNNANELPAPFKALQMGNVWRADRPQRGRFRQFMQCDIDILGEPTYLAEIELVLATTTLLGKLDFHNFTIRINDRKILKAMAQYSGFPQESFDTVFIILDKMDKIGLEGVAEELEKEGFAKESIDTYLGLFKEITSDIEGVRYCKEKLKDVLDPKVAEDLETIISTVDSVKTADFKMSFDPTLVRGMSYYTGPIFEISMDEFGGSVGGGGRYDEMIGKFTGNNTSACGFSIGFERIVMLLLERNYEIPTKNGKKAYLIEKNMPADKMLTILKQAQEERNAGTQINISIMKKNKKFQKDQMTAEGYTEFVEFFKDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EJN7</accession>
    <name>A0A174EJN7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">rplS</name>
        <name evidence="5" type="ORF">ERS852478_02600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200799.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36609">
        <property type="protein sequence ID" value="CUO36609"/>
        <property type="gene ID" value="ERS852478_02600"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO36609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="115" mass="12896" checksum="55856ABDEF5986CF" modified="2016-09-07" version="1">MNEIIKNIEAAQLKAEVPAFNTGDTVRVHALIKEGNRERVQVFEGTVLKKQGGSNRATFTVRKSSNGVGVEKTWPLHSPHVVKVEVIRRGKVRRAKLNYLRERVGKAAKVKELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EL32</accession>
    <name>A0A174EL32_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl esterase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Acetylxylan esterase</fullName>
            <ecNumber evidence="3">3.1.1.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">axeA1</name>
        <name evidence="3" type="ORF">BWLFYP14_00915</name>
        <name evidence="2" type="ORF">ERS852478_02652</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.72" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707808.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38513">
        <property type="protein sequence ID" value="CUO38513"/>
        <property type="gene ID" value="ERS852478_02652"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046555">
        <property type="term" value="F:acetylxylan esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="44"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO38513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX63437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="272" mass="30576" checksum="AB42E5DA2BFF37E2" modified="2016-09-07" version="1">MIYKKIEIAVDGYKETADLYTYFLDNSIEMHINRKRPVVVICPGGGYAMTSDREAEPIAMQYLVRGYHAVILRYSVEPARYPLALLQLAKSVAFLRKNAAEFHIDTNKIVLQGFSAGGHLAASLGVFWKKDFIAQTLGVTSDMVKPNGMILSYPVITSGEFAHTGSFECLLGEDYNDLDKRKEQSLEFQVSKDTPTTFLWHTVTDDCVPVENSLLFFNALRKFEIPVEMHLYPVGGHGLSLANEETSNEDGGCVQKECQSWIELACKWMQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ELZ7</accession>
    <name>A0A174ELZ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FtsH protease regulator HflK</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Modulator of FtsH protease HflK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">qmcA</name>
        <name evidence="5" type="synonym">hflK_2</name>
        <name evidence="5" type="ORF">BWLFYP14_00907</name>
        <name evidence="3" type="ORF">ERS852478_02644</name>
        <name evidence="4" type="ORF">ERS852523_02305</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000023">
        <property type="protein sequence ID" value="CUP64355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000055_gene1901"/>
    <dbReference type="EnsemblBacteria" id="CUO38267">
        <property type="protein sequence ID" value="CUO38267"/>
        <property type="gene ID" value="ERS852478_02644"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP64355">
        <property type="protein sequence ID" value="CUP64355"/>
        <property type="gene ID" value="ERS852523_02305"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO38267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP64355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX63429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="313" mass="34461" checksum="B1B32CFF47E83116" modified="2016-09-07" version="1">MGVVFLIVIIVIAVWVLASCVRIVPQAYAVILERLGAYQATWSTGIHFKVPFIERVARKVNLKEQVVDFPPQPVITKDNVTMQIDTVVFFQITDPKLYTYGVENPIMAIENLSATTLRNIIGDMELDETLTSRETINTKMRASLDEATDPWGIKVNRVELKNIIPPAAIQDAMEKQMKAERERREAILIAEGQKKSTILVAEGKKQSAILDAEAEKQAAILRAEAQKERMIKEAEGQAEAVLKVQNANAEGIRMIREAGADEAVLTLKSLEAFARAADGKATKIIIPSDIQGIAGLASSLKEIVTDPKAETDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EN49</accession>
    <name>A0A174EN49_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yqfA</name>
        <name evidence="7" type="ORF">ERS852478_02675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0073 (Hly-III) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO39234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200826.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39234">
        <property type="protein sequence ID" value="CUO39234"/>
        <property type="gene ID" value="ERS852478_02675"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005744">
        <property type="entry name" value="Hy-lIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01065">
        <property type="entry name" value="hlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO39234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="220" mass="24421" checksum="69989C45FC762966" modified="2016-09-07" version="1">MKFKLKDPGSAITHGIALLLAAVGAVPLIIKAARSYDVLHIVALSIFILTMVLLYAASTIYHSVNSTEKVNRRLRKMDHMMIFVMIAGSYTPVCLIVLHNRIGYILCALVWSIAVLGIILKGCWITCPKWLSSVLYIAMGWLCVLAFVPIFHALPRAGFDWLLAGGIIYTIGGVIYALKVPLFNSRHKNFGSHEIFHIFVMLGSACHFIVMYFFVAPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ENJ0</accession>
    <name>A0A174ENJ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione import ATP-binding protein GsiA</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Oligopeptide transport ATP-binding protein OppD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_9</name>
        <name evidence="7" type="synonym">oppD_1</name>
        <name evidence="7" type="ORF">BWLFYP14_00899</name>
        <name evidence="6" type="ORF">ERS852478_02636</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707784.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38039">
        <property type="protein sequence ID" value="CUO38039"/>
        <property type="gene ID" value="ERS852478_02636"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO38039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX63421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="337" mass="37409" checksum="5AC0534241BF4492" modified="2016-09-07" version="1">MEHLLEVKNLSVSIDGPAGEVQAVRDVSFSLKRGEVLAIVGESGCGKSVLCKSIMKLLPPSAKIKEGSICVNGQDITCYREREMQKLRGRVFAMIFQDPMTSLNPTIKIGKQIGEAVVIHNKNYTKEQVNKKVLELMELVGISHPKERYHQYPWQFSGGMRQRCVMAIALAADPDILFADEPTTALDVTIQAQILDLLREIQMKLGTATILVSHDLGVVARVADRVAVMYAGKIVEIGTVEEVYYDPRHPYTWGLMRSLPAFANGKESLYTIPGMPPALIDPPKGDAFACRNEYALNIDYEEMPPMFKITDTHYAATWLLDPRAPQIKSPVGGIVHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EPX1</accession>
    <name>A0A174EPX1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-ACP thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BWLFYP14_00919</name>
        <name evidence="6" type="ORF">ERS852478_02656</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-ACP thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707812.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38636">
        <property type="protein sequence ID" value="CUO38636"/>
        <property type="gene ID" value="ERS852478_02656"/>
    </dbReference>
    <dbReference type="GeneID" id="66492682"/>
    <dbReference type="eggNOG" id="COG3884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:acyl-[acyl-carrier-protein] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002864">
        <property type="entry name" value="Acyl-ACP_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045023">
        <property type="entry name" value="FATA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31727">
        <property type="entry name" value="PTHR31727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01643">
        <property type="entry name" value="Acyl-ACP_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO38636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX63441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="236" mass="26851" checksum="6E219600944D5AF5" modified="2016-09-07" version="1">MNYSFNSRVRYSETGENGKLTLPGVLNYFQDCCTFHAESVGLGGDVLKARDRAWVLSSWQVIVDEYPAMGTEIRITTAPYDFKGFMGMRNFTIETMDGKKLAWANSNWTHLAISTGIPVRLTPADTDNYILGEKLEMDYAPRKIKLPDDMTSQESFTVQKHHLDTNHHVNNCQYICMAEDFLPEDFKVYQMRAEYKMQAKLGDIICPKAKAETGKVIVSLDDTDGKAYAIIEFQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EQU7</accession>
    <name>A0A174EQU7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hef nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_02666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38976">
        <property type="protein sequence ID" value="CUO38976"/>
        <property type="gene ID" value="ERS852478_02666"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013663">
        <property type="entry name" value="Helicase_SWF/SNF/SWI_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08455">
        <property type="entry name" value="SNF2_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="646"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="980"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO38976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1144" mass="130412" checksum="EF4742DA38A90A23" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ETC2</accession>
    <name>A0A174ETC2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Germination-specific N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase LytC</fullName>
            <ecNumber evidence="3 4">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lytC_1</name>
        <name evidence="4" type="synonym">cwlD</name>
        <name evidence="4" type="ORF">BWLFYP14_00582</name>
        <name evidence="3" type="ORF">ERS852478_02720</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.28" evidence="3 4"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40771">
        <property type="protein sequence ID" value="CUO40771"/>
        <property type="gene ID" value="ERS852478_02720"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033255387" evidence="1">
        <location>
            <begin position="26"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="2">
        <location>
            <begin position="111"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO40771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX62804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="231" mass="25965" checksum="FA18017612C6016D" modified="2016-09-07" version="1">MKKYGLELMLGCLLLVSFLILSKQAAEVSETMSSTENSKIILVDAGHGGADPGMIGVNGLEEKGINLQIAVKLKDSLEKQGFSVIMTREEDKGLYEEDSRNQKAQDMQCRIAMIKKYRPVLCISVHQNSYQDSSVCGPQVFYYEDSVRGKNLAEFIQEELNLGLKVKRPRVAKGNKTYYLLKRSESVLNIVECGFLTNPEEAGLLCKEEYQNKIVEAIVKGIEQYLKQQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EUY5</accession>
    <name>A0A174EUY5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIE family protein phosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein E</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoIIE_2</name>
        <name evidence="5" type="synonym">spoIIE_1</name>
        <name evidence="5" type="ORF">BWLFYP14_00600</name>
        <name evidence="2" type="ORF">ERS852478_02704</name>
        <name evidence="4" type="ORF">GT712_18405</name>
        <name evidence="3" type="ORF">GT728_09435</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
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        <property type="protein sequence ID" value="CUO40376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000019">
        <property type="protein sequence ID" value="MZL33413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000060">
        <property type="protein sequence ID" value="MZS90964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707956.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40376">
        <property type="protein sequence ID" value="CUO40376"/>
        <property type="gene ID" value="ERS852478_02704"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045768">
        <property type="entry name" value="SpoIIE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19732">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPM_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="285"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO40376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX62822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="497" mass="56873" checksum="752740407D7CD9EC" modified="2016-09-07" version="1">MQEWMIAMLVISIMLIIRDMAKTILAENLPDTEELPSLQEGHPQKERVEKYAASFQKLADTFYGMPYRKDYLSSRQVEQIIEDTNAKVCSRCYQREICWGEHSQELVKGVEALVRSMESGNEENVRGIRADWTGICPRSVQYYETVAENFQKERQNLMWDNRMIENRLAVAQQLMEVSHIMENVASDLYDLERVTPQFEEELRKGLRKSHVILRRAWMMNKVKGRKQIFLTMRARSGQCISMTEIAQLLSKYCEISMVPVNGSRCIVNGEYHTVHFAEDVSYQVLYGTARLTREEEKVSGDNYICRQEDGGRFVMCLSDGMGSGMEACRESETVVELLEQFMESGFSQETAAKMVNSALVLKGEEGMFSTVDICAVDLYTGICNFLKAGAASTFIKRDHWVESITSESLAAGLVQQIDFETATRKLYHGDYLIMMTDGVLDALPDQKEEETMKEIIMDVHEESPKDFGRGILERVLGYSDYHARDDMTVLVAGVWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EYC1</accession>
    <name>A0A174EYC1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS200/IS605 family transposase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Transposase IS200 like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transposase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tnpA</name>
        <name evidence="5" type="ORF">BWLFYP14_00366</name>
        <name evidence="2" type="ORF">ERS852478_02767</name>
        <name evidence="3" type="ORF">ERS852523_02702</name>
        <name evidence="4" type="ORF">GT712_13510</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000030">
        <property type="protein sequence ID" value="CUP75604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000028">
        <property type="protein sequence ID" value="MZS90060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707451.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000026_gene1013"/>
    <dbReference type="EnsemblBacteria" id="CUO42461">
        <property type="protein sequence ID" value="CUO42461"/>
        <property type="gene ID" value="ERS852478_02767"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP75604">
        <property type="protein sequence ID" value="CUP75604"/>
        <property type="gene ID" value="ERS852523_02702"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="11"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO42461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP75604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX67521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="135" mass="16183" checksum="B624E1140969577F" modified="2016-09-07" version="1">MEKIDHNAHSVYLMYYHLIMVVKYRRKVINDPISERAKEIWEYIAPRYGIVLEEWNHDIDHVHVMFRAQPKTELSKFINAYKSASSRLLKKEYPEIREKLWKEAFWSQSFCLLTAGGAPVEVIRQYIETQGEKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZH6</accession>
    <name>A0A174EZH6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="3">5.3.3.2</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">idi</name>
        <name evidence="3" type="ORF">ERS852478_02782</name>
        <name evidence="4" type="ORF">GT728_15820</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000046">
        <property type="protein sequence ID" value="MZL34622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705266.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42871">
        <property type="protein sequence ID" value="CUO42871"/>
        <property type="gene ID" value="ERS852478_02782"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO42871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="167" mass="19164" checksum="A313664B308A8C39" modified="2016-09-07" version="1">MEFWDIYDENKKPTGRTMKRNDWCLKDGEYHLTVLGVVGRPDGTFLITKRVMTKAWAPGWWEVSGGAAQAGEESCEAVLREVKEETGLDVRNAEGGYLFTYKRENPGEGDNYFVDVYRFVMDIDESDLHLQTEETDGYMFATVDEIKAFAAEGKFLHYDSIKKAFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F1I8</accession>
    <name>A0A174F1I8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribose import ATP-binding protein RbsA</fullName>
            <ecNumber evidence="5">3.6.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rbsA_4</name>
        <name evidence="5" type="ORF">ERS852478_02809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.17" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705208.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43561">
        <property type="protein sequence ID" value="CUO43561"/>
        <property type="gene ID" value="ERS852478_02809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="258"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO43561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="498" mass="54904" checksum="D5ACADAC618144DE" modified="2016-09-07" version="1">MGEILLRAENIDKHFGITHALDNVSFTFNKGEIHALIGENGSGKSTLTSCLTGIYQKDSGKFILEGKEITATNQVEANHQGVAIIVQEIGTLSGLTVAENIFLGNEDQFTKCGIKNTAAMNKKAQEYLDSYGFNYIDATKVIDDYNFEDRKLVEIVKSTYFNPKVLVVDETTTALGQKGREELFKVMHKVRDTGNCVIFISHDLEEVIEQSDNISVLRDGVKIGSITKEEATPDRLKALMVGREIGDSYYRTDYGEKVSDEVVLSAKNVTVKGQIENLNLDLHKGEILGIGGLSECGMHEVGKALFGASYFRQGSVTLGDGTPINSIPDAIKHSIAYASKDRDNESLVINDTIGDNICLPSLEDLKTHGFLRAKTMNEFANKFAKQMSTKMTGVDQFVSALSGGNKQKVVLARWVGKDSDLIILDSPTRGIDVKVKADIYAMMNDMRKRGKSIIMISEEIMELLGMADRILIMKDGKINGEFLRSPDLKDTDLIDNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F4R2</accession>
    <name>A0A174F4R2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sulfate transport system permease protein CysW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysW_2</name>
        <name evidence="11" type="ORF">ERS852478_02815</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200941.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43739">
        <property type="protein sequence ID" value="CUO43739"/>
        <property type="gene ID" value="ERS852478_02815"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011866">
        <property type="entry name" value="CysW_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406:SF1">
        <property type="entry name" value="PTHR30406:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02140">
        <property type="entry name" value="permease_CysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="60"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO43739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="274" mass="30218" checksum="B2C26F0DCE0DDD54" modified="2016-09-07" version="1">MDNNEKTSEKITKWLLVVISVLFLAIMLLLPLITVITEALRSGWKVYAAAVTDEYTIKALLLTVKATLFAVVFNTVFGVFAAWALTKFQFRGKKLLTTLIGLPVTISPVIAGLIFLLIFGRQSPVYFFLMKLGIKVVFSVPGIIIATVFVTFPFISRELIPVLEAEGSDEEEAAALMGAGGWTIFWKITFPHIKWALLYGVVLCTARAMGEFGAVSVLSGHLRGKTNTLPLHVEILFNEFQYVPAFAVSSLLVIMAVIILVVRSLIEYKGKKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F8P5</accession>
    <name>A0A174F8P5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Complexin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_03410</name>
        <name evidence="1" type="ORF">ERS852478_02902</name>
        <name evidence="2" type="ORF">GT712_17980</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000055">
        <property type="protein sequence ID" value="MZS90885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705149.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46583">
        <property type="protein sequence ID" value="CUO46583"/>
        <property type="gene ID" value="ERS852478_02902"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO46583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS90885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX67133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="79" mass="9817" checksum="DA6D426FD638AEE6" modified="2016-09-07" version="1">MQNRNVQIPYELFLQLLQYFLMDNYDGEEKIRLGLEQKLDAMVNREMYSKFKTAPTEEEREKFRQEYLDRKGIQESFRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FBM6</accession>
    <name>A0A174FBM6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 5">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpsL</name>
        <name evidence="11" type="ORF">BWLFYP14_03389</name>
        <name evidence="7" type="ORF">ERS852478_02926</name>
        <name evidence="8" type="ORF">ERS852523_03100</name>
        <name evidence="10" type="ORF">GT712_01140</name>
        <name evidence="9" type="ORF">GT728_08650</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 4 5">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000039">
        <property type="protein sequence ID" value="CUP87023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000016">
        <property type="protein sequence ID" value="MZL33264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705161.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000065_gene675"/>
    <dbReference type="EnsemblBacteria" id="CUO47171">
        <property type="protein sequence ID" value="CUO47171"/>
        <property type="gene ID" value="ERS852478_02926"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP87023">
        <property type="protein sequence ID" value="CUP87023"/>
        <property type="gene ID" value="ERS852523_03100"/>
    </dbReference>
    <dbReference type="GeneID" id="66494689"/>
    <dbReference type="eggNOG" id="COG0048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO47171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP87023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS87729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX67112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="138" mass="15211" checksum="43526252CA5E2D0D" modified="2016-09-07" version="1">MPTFNQLVRKGRQTSVKKSTAPALQKTFNSLRKKAVEQSAPQKRGVCTAVKTATPKKPNSALRKIARVRLSNGIEVTSYIPGEGHNLQEHSVVLIRGGRVKDLPGTRYHIIRGTLDTAGVANRKQARSKYGAKRPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FDM0</accession>
    <name>A0A174FDM0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46245">
        <property type="protein sequence ID" value="CUO46245"/>
        <property type="gene ID" value="ERS852478_02888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026989">
        <property type="entry name" value="TnpV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14198">
        <property type="entry name" value="TnpV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO46245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="86" mass="10266" checksum="CD6A2980D63A72BC" modified="2016-09-07" version="1">MLRKQFLKEHRSAKYQYLLLTGKLTEHLNQIDQEARKQVEILMEQMVKKQGATEELKAQDQMKWVRLMINIKSSAEEIVVKNTIYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FH28</accession>
    <name>A0A174FH28_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Plasmin and fibronectin-binding protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pfbA</name>
        <name evidence="5" type="ORF">ERS852478_02935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201010.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47425">
        <property type="protein sequence ID" value="CUO47425"/>
        <property type="gene ID" value="ERS852478_02935"/>
    </dbReference>
    <dbReference type="GeneID" id="66494698"/>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="12"/>
    </dbReference>
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        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021676" evidence="2">
        <location>
            <begin position="31"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="4">
        <location>
            <begin position="212"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="NosD" evidence="3">
        <location>
            <begin position="530"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO47425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="696" mass="75506" checksum="6D4B1BCACD30745F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FL47</accession>
    <name>A0A174FL47_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
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        <name evidence="10" type="primary">atpC_2</name>
        <name evidence="6 12" type="synonym">atpC</name>
        <name evidence="14" type="ORF">BWLFYP14_03554</name>
        <name evidence="10" type="ORF">ERS852478_03039</name>
        <name evidence="11" type="ORF">ERS852523_01447</name>
        <name evidence="13" type="ORF">GT712_01575</name>
        <name evidence="12" type="ORF">GT728_10260</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">2789STDY5834863</strain>
            <strain evidence="11 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 19">BIOML-A1</strain>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP38599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000021">
        <property type="protein sequence ID" value="MZL33572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704958.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000037_gene3254"/>
    <dbReference type="EnsemblBacteria" id="CUO50923">
        <property type="protein sequence ID" value="CUO50923"/>
        <property type="gene ID" value="ERS852478_03039"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP38599">
        <property type="protein sequence ID" value="CUP38599"/>
        <property type="gene ID" value="ERS852523_01447"/>
    </dbReference>
    <dbReference type="GeneID" id="66495477"/>
    <dbReference type="eggNOG" id="COG0355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036794">
        <property type="entry name" value="ATP_F1_dsu/esu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020547">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
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        <property type="entry name" value="ATP-synt_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46604"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="9">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_DE" evidence="8">
        <location>
            <begin position="87"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO50923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP38599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL33572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS87814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX67279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="133" mass="14633" checksum="719B98CD1981576A" modified="2016-09-07" version="1">MSTFPLRIGTPDGLLFEGNVERVICRTVSGDLAILARHCNYCTALGMGEASVVMEDGSRRTAACIGGMLSVMNGKCRVLATTWEWKEDIDEQRAQEAKKRAEEMIAKGGLSDHDYKIVEAKLQRALVRLSVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FLD3</accession>
    <name>A0A174FLD3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_03532</name>
        <name evidence="1" type="ORF">ERS852478_03017</name>
        <name evidence="2" type="ORF">ERS852523_03221</name>
        <name evidence="4" type="ORF">GT712_01465</name>
        <name evidence="3" type="ORF">GT728_10150</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000021">
        <property type="protein sequence ID" value="MZL33550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993174.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000010_gene2799"/>
    <dbReference type="EnsemblBacteria" id="CUO50327">
        <property type="protein sequence ID" value="CUO50327"/>
        <property type="gene ID" value="ERS852478_03017"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP90561">
        <property type="protein sequence ID" value="CUP90561"/>
        <property type="gene ID" value="ERS852523_03221"/>
    </dbReference>
    <dbReference type="GeneID" id="66495455"/>
    <dbReference type="eggNOG" id="ENOG50347XV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO50327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP90561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS87792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX67257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="61" mass="6863" checksum="8D95CDA0189C8319" modified="2016-09-07" version="1">MGNATESTLPHGNTSGYDRKACRTCACSTCYEQEFCDRCSSCQNQSRKLDRCNAYEGAYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FLI9</accession>
    <name>A0A174FLI9_9FIRM</name>
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        <submittedName>
            <fullName evidence="9">2,3-dimethylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="9">4.2.1.85</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dmdA_2</name>
        <name evidence="9" type="ORF">ERS852478_03027</name>
        <name evidence="10" type="ORF">GT712_01515</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
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    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50581">
        <property type="protein sequence ID" value="CUO50581"/>
        <property type="gene ID" value="ERS852478_03027"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:iron-sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
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        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
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            <begin position="40"/>
            <end position="469"/>
        </location>
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        <location>
            <begin position="640"/>
            <end position="685"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO50581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS87802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="752" mass="81721" checksum="DC9F82402D861686" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FQG0</accession>
    <name>A0A174FQG0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">F-type ATPase subunit c</fullName>
            <shortName evidence="12">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">atpE_2</name>
        <name evidence="12 16" type="synonym">atpE</name>
        <name evidence="18" type="ORF">BWLFYP14_03548</name>
        <name evidence="14" type="ORF">ERS852478_03033</name>
        <name evidence="15" type="ORF">ERS852523_01441</name>
        <name evidence="17" type="ORF">GT712_01545</name>
        <name evidence="16" type="ORF">GT728_10230</name>
    </gene>
    <organism evidence="14 19">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 19 20" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 19">2789STDY5834863</strain>
            <strain evidence="15 20">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="16 22 23" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 23">BIOML-A1</strain>
            <strain evidence="17 22">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="18 21" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP38423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000021">
        <property type="protein sequence ID" value="MZL33566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704968.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000037_gene3260"/>
    <dbReference type="EnsemblBacteria" id="CUO50740">
        <property type="protein sequence ID" value="CUO50740"/>
        <property type="gene ID" value="ERS852478_03033"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP38423">
        <property type="protein sequence ID" value="CUP38423"/>
        <property type="gene ID" value="ERS852523_01441"/>
    </dbReference>
    <dbReference type="GeneID" id="66495471"/>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="13">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="12">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO50740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUP38423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZL33566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MZS87808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VUX67273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="92" mass="9165" checksum="16C7C3D2828CB5B4" modified="2016-09-07" version="1">MDFQLLAKGIALAGCAIGAGCALIAGIGPGIGEGNAVAKALEAIGRQPECKGDVTSTMLLGCAIAETTGIYGFVTGLLLIFVAPGMFMNFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FVJ8</accession>
    <name>A0A174FVJ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cssS_1</name>
        <name evidence="10" type="ORF">ERS852478_03086</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO52836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201132.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52836">
        <property type="protein sequence ID" value="CUO52836"/>
        <property type="gene ID" value="ERS852478_03086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="159"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="226"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO52836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="440" mass="50367" checksum="3BAE4DB7E19BED51" modified="2016-09-07" version="1">MEKLKRSRLFNRLNSMSIRMSFVLYALFSLLIGIIICIFLISMVDRYRINLNYKYENMSTRYDIPENGSFTATYSNDQTKYTIFDTKGNEICKFNVDYQKERPVHEYVYPNHVSYIEVLPNFTNRDRLIDSALGSLNIAIIPIVLSISMICCVTFFYKKKLSKPIKLLTNAYHKIEANDLDFTLSYPLNDEMGKLCHAFEKMKDCLSKNNETMFRQFAEQRRLNAAFSHDLRTPLTLLKGHATMLLSFIPKGLVSQEEILDEISVMSKNISRLEKYVNAMTNLYRLEDIDIPRQPITFHSLIDNFHNTAEVLCYDKHFSITTSGDNIILFINLDTVMQIYENLLANSIRYAKSDIAISVVIENNNLVISVSDDGCGFKNIEIEKATLPFYKSSKDISTEHLGLGLNISKILSERHGGNIQIANNKAGGACVTVKINCNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FWW5</accession>
    <name>A0A174FWW5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201144.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53060">
        <property type="protein sequence ID" value="CUO53060"/>
        <property type="gene ID" value="ERS852478_03093"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032VZW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025468">
        <property type="entry name" value="TTRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041965">
        <property type="entry name" value="TTRAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14203">
        <property type="entry name" value="TTRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO53060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="68" mass="7809" checksum="5C1FD981F7D31B90" modified="2016-09-07" version="1">MIRLTVEETNLLSIYHEGSKAQLMENMTATLPFMDEDMRPFAERTLQKISPLTENEYAELAIFAADEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G3U1</accession>
    <name>A0A174G3U1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">phoR_9</name>
        <name evidence="9" type="synonym">phoR_10</name>
        <name evidence="8" type="ORF">ERS852478_03158</name>
        <name evidence="9" type="ORF">ERS852523_03525</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
            <strain evidence="9 11">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000053">
        <property type="protein sequence ID" value="CUP98845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055153205.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000152_gene3981"/>
    <dbReference type="EnsemblBacteria" id="CUO55015">
        <property type="protein sequence ID" value="CUO55015"/>
        <property type="gene ID" value="ERS852478_03158"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP98845">
        <property type="protein sequence ID" value="CUP98845"/>
        <property type="gene ID" value="ERS852523_03525"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="129"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO55015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP98845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="345" mass="38965" checksum="EA03984B9E05B735" modified="2016-09-07" version="1">MKILANKEIKNLFHSLSLVFGVTFLLAEVFLWLSYRRLSLLLLILFLLAGGAVWAVCFVYFNRQNQIMEQAILQINAYLDGDRNARIECDNEGELYRLFHSINSLAAVLNAHADNELREKEFLKNTISDISHQLKTPLAALNIYNGLLQDEDIEVSSVKEFAGLSEQELDRIETLVQSLLKITRLDAGAIVLEKNAENVADMMRDIELHFAYRARQEKKEIILSGSDHLSLFCDRDWLNEAIDNIVKNAFDHTESGATIRVAWKELPSGVQIVITDNGCGIHPEDIHHIFKRFYRSRFSKDTQGIGLGLPLAKAIIEAHGGLIEVESELGIGTSFIMNFPIPTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G5G8</accession>
    <name>A0A174G5G8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminodeoxychorismate/anthranilate synthase component II</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Para-aminobenzoate synthase glutamine amidotransferase component II</fullName>
            <ecNumber evidence="2">2.6.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pabA</name>
        <name evidence="2" type="ORF">ERS852478_03232</name>
        <name evidence="3" type="ORF">GT712_16690</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.85" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000045">
        <property type="protein sequence ID" value="MZS90650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381370.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57734">
        <property type="protein sequence ID" value="CUO57734"/>
        <property type="gene ID" value="ERS852478_03232"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO57734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="192" mass="21268" checksum="D7167A07A5A683E7" modified="2016-09-07" version="1">MILLIDNYDSFSYNLYQLIGAVEPDIKVVRNDECTLEEIAEMKPEAIILSPGPGRPEDAGICIPVIKEFAGKIPILGVCLGHQSICEAFGGTVSYAKELMHGKKKLMYKTGESRLFKDLPDTFAAARYHSLAALKDTLPAELKVTAESEDGEVMAVEHTKYPVFGVQFHPESVMTPDGRVMIENFMEVVRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G5N6</accession>
    <name>A0A174G5N6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380857.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPB010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57872">
        <property type="protein sequence ID" value="CUO57872"/>
        <property type="gene ID" value="ERS852478_03240"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO57872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="133" mass="15302" checksum="7A055EA49127491D" modified="2016-09-07" version="1">MREKNIQGVFNLESLMKRQLAALVHCVRRTALMRVTDMTGTMTKRIAGGIINASIIMKNMPCHNRKHSRYGKNKKELLVILSLKDDKGEQRYCQVAPRCLYLDDYKNLTDGIDGNKRLAFVLCFLSFFVSEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GAZ2</accession>
    <name>A0A174GAZ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO58059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380852.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPB010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58059">
        <property type="protein sequence ID" value="CUO58059"/>
        <property type="gene ID" value="ERS852478_03248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="171" mass="20231" checksum="0092C89639819B08" modified="2016-09-07" version="1">MQGYKDLVIQAKNDSKYMQSLLCIMEPLVKSYAKKIFFLDWDDATQELNLAIIEAVKTIATCEDDYQCLKFITNSVKYKFAHLCKRNLKKEKYECAYMDNEGDLQESYRADYSSVELAFDLKNITLKMTSNQRDILKYLILGWSDSEIASFLHFSRQYVNREKKKIYQFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GDZ8</accession>
    <name>A0A174GDZ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calcium/sodium antiporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7 9">inner membrane protein YrbG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yrbG</name>
        <name evidence="9" type="ORF">BWLFYP14_03480</name>
        <name evidence="7" type="ORF">ERS852478_03263</name>
        <name evidence="8" type="ORF">GT712_16830</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO58645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000046">
        <property type="protein sequence ID" value="MZS90677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705126.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58645">
        <property type="protein sequence ID" value="CUO58645"/>
        <property type="gene ID" value="ERS852478_03263"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00367">
        <property type="entry name" value="TIGR00367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <sequence length="310" mass="33377" checksum="F201CB20676B45CC" modified="2016-09-07" version="1">MMFLQVIILLAGFLFLVKGADWFVEGAASIAKKLGIPQLIIGLTIVAMGTSMPEAAVSITAAINKNAGITIGNVVGSNILNIFIILGITAVITNVAIQKSTLLYEIPFMTVITIILLIFGITGSEVTFIEGVIFWILFLIYLGYLFVMAKKGNDQEEAEAKDNPVWKCMLLMVIGGILVVKGSDFAVSGATEIARYFGMSERFIGLTIVALGTSLPELVTSVTAARRGNTGIAIGNIVGSNIFNILFVIGTTALICTVPFESKFIIDTVIAVLCGVILWIGTFRHKELRKPCGVVMLLCYVAYFLYLCLV</sequence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
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                <person name="Groussin M."/>
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                <person name="Livny J."/>
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                <person name="Raman A."/>
                <person name="Venkatesh S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GTK6</accession>
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    <reference evidence="14 19 20" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 19">2789STDY5834863</strain>
            <strain evidence="15 20">2789STDY5834911</strain>
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    </reference>
    <reference evidence="16 22 23" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
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                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 23">BIOML-A1</strain>
            <strain evidence="17 22">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="18 21" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H(+) + L-aspartate = beta-alanine + CO2</text>
            <dbReference type="Rhea" id="RHEA:19497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="EC" id="4.1.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="9 10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooctamer of four alpha and four beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9 12">Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PanD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.11" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000032">
        <property type="protein sequence ID" value="CUP77447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000024">
        <property type="protein sequence ID" value="MZL33685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000042">
        <property type="protein sequence ID" value="MZS90574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704365.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000077_gene2644"/>
    <dbReference type="EnsemblBacteria" id="CUO64210">
        <property type="protein sequence ID" value="CUO64210"/>
        <property type="gene ID" value="ERS852478_03433"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP77447">
        <property type="protein sequence ID" value="CUP77447"/>
        <property type="gene ID" value="ERS852523_02761"/>
    </dbReference>
    <dbReference type="GeneID" id="66495124"/>
    <dbReference type="eggNOG" id="COG0853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004068">
        <property type="term" value="F:aspartate 1-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006523">
        <property type="term" value="P:alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06919">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00446">
        <property type="entry name" value="PanD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003190">
        <property type="entry name" value="Asp_decarbox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21012">
        <property type="entry name" value="PTHR21012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02261">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006246">
        <property type="entry name" value="Asp_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00223">
        <property type="entry name" value="panD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 9" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8 9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5014213288" description="Aspartate 1-decarboxylase beta chain" evidence="9 13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014213287" description="Aspartate 1-decarboxylase alpha chain" evidence="9 13">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="73"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="9 10">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser)" evidence="9 12">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006246-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO64210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUP77447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZL33685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MZS90574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VUX65902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="130" mass="14356" checksum="F431951B186AB950" modified="2016-09-07" version="1">MTIEMLKGKIHRATVIQAELDYVGSITVDEELLEAAGILEYEKVQIVDVNNGSRFETYTICGKRGSGMICLNGAAARCVSTGDKIIIMAYAGYEPEEARTHKPAVVFVDEENKISRVTNYEKHGLLKDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H0V1</accession>
    <name>A0A174H0V1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug export protein mepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_17</name>
        <name evidence="2" type="ORF">ERS852478_03501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060813.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66415">
        <property type="protein sequence ID" value="CUO66415"/>
        <property type="gene ID" value="ERS852478_03501"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="95"/>
            <end position="117"/>
        </location>
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        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO66415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="458" mass="49997" checksum="57C485A1144149DF" modified="2016-09-07" version="1">MNTTANLGKAPVRTLVLQLAIPSMTAQFVNVLYSIIDRMYIGHISENGALALAGAGICGPIVTLLTSFGTLVGIGGSITMGIRMGEKNHKKAEQVLANSFLMLSIFSVLLTVSFLLLKDKLLMLFGASGATFPFANTYLTIYTTGTFFALMATGLNYFINCQGFPLVGMFTVLIGAGCNILSDPIFIFGFHMGISGAAIATVISQILSCIFAMTFLLGKKVPVKITFGQYNLKVIRKILSLGFSPFLILATDSLILIFMNTVLQKYGGASQGDMLITCATIAQSYLLLITSPMIGISGGTQAILSYNYGARCVNRVKDAERNILRVMLIFTTIMFLLSRFIPRYFVLLFTTNPQYIRFSVWVIRTYTLMIIPLSFQYVFVDGLTALECPKTGLALSVTRKSLFVISAAVLPSFFGAKAAFFAEPVADGISSVLSTIVFLLLINRHLDKRYRMDKKESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H3N5</accession>
    <name>A0A174H3N5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2992 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF2992)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01607</name>
        <name evidence="2" type="ORF">ERS852478_03547</name>
        <name evidence="4" type="ORF">GT712_09265</name>
        <name evidence="3" type="ORF">GT728_08370</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000015">
        <property type="protein sequence ID" value="MZL33211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705642.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67680">
        <property type="protein sequence ID" value="CUO67680"/>
        <property type="gene ID" value="ERS852478_03547"/>
    </dbReference>
    <dbReference type="GeneID" id="66494971"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016787">
        <property type="entry name" value="UCP021328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11208">
        <property type="entry name" value="DUF2992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021328">
        <property type="entry name" value="UCP021328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO67680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="138" mass="16562" checksum="3F0BB404DEBA5E7D" modified="2016-09-07" version="1">MDKVNGKLTVFFEEPFWVGIFERIEDGKLSVAKVTFGAEPKDYEVQEYIQKCYFSLKFSPVVETVVKDIKRNPKRMQREAKKQMLEIGIGTKSQQALKLQQEQNKQERKEKRRKKKEAEEQRMFELKQRKKREKHKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HAB7</accession>
    <name>A0A174HAB7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glpK_2</name>
        <name evidence="3" type="ORF">ERS852478_03630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO70158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201470.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70158">
        <property type="protein sequence ID" value="CUO70158"/>
        <property type="gene ID" value="ERS852478_03630"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="247"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO70158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="450" mass="50059" checksum="4A15EE6DD7140B02" modified="2016-09-07" version="1">MKTAGIDIGTTTISGVVLEKEENGQAKILEAKTVENGCFIETGNEWERIQYAKEIVERAVNLLDYFLEKYPHVERIGLTGQMHGIVYVDKEGNCVSPLYTWQDARGSICDGDQIPLTEEIRERCQIHAASGYGLVTHIYNIRHNLVPDSALSFCTIMDYFGMYLTGRKKTLVHVSNAASFGFFDSHKMCFEKEKLAEMGVDVNWLPDVCTGIEKLGTYRGRTVTTAIGDNQASFLGAAGDEENILLVNMGTGGQISVLSSQYFSGDGIEARPFLNRKYLLVGASLCGGKAYALLEQFFRKIVKEATGQEQPLYKVMEKMARTGRDQNSERTESRKIKVETTFDGTRVNPEKSGSITQICSENFTPEDFCYGVLKGMSTELYQMYMTIQKGIGIKIRRMIGSGNGLRKNPVLCEIIEDMFKAELVLAECEEEAATGAAMSSSMYNYSNSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KGM7</accession>
    <name>A0A174KGM7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine metabolism repressor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">HTH-type transcriptional regulator CymR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cymR_1</name>
        <name evidence="1" type="synonym">cymR_2</name>
        <name evidence="4" type="ORF">BWLFYP14_03052</name>
        <name evidence="1" type="ORF">ERS852478_01182</name>
        <name evidence="2" type="ORF">ERS852523_00502</name>
        <name evidence="3" type="ORF">GT712_03670</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
            <strain evidence="2 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP08410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381064.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2121"/>
    <dbReference type="EnsemblBacteria" id="CUN82993">
        <property type="protein sequence ID" value="CUN82993"/>
        <property type="gene ID" value="ERS852478_01182"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08410">
        <property type="protein sequence ID" value="CUP08410"/>
        <property type="gene ID" value="ERS852523_00502"/>
    </dbReference>
    <dbReference type="GeneID" id="66494017"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="CUN82993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP08410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS88211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="158" mass="17149" checksum="F6B46A2A998561C2" modified="2016-09-07" version="1">MKLSTRARYGLKALIDLGLHSANEAISLQSIAERQDISTSYLEQLMAMLKKAGLVKSSRGAYGGYQLGKPADEISVGEVLRVLEGSLEAAACPGIENDGTCHGSDVCVAKLVWKRINDSITSAVDTLMLGQLIEESRRVHEEKMESQGMEENVPDILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KQU1</accession>
    <name>A0A174KQU1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Arginine transport system permease protein ArtQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">artQ_1</name>
        <name evidence="8" type="synonym">artQ</name>
        <name evidence="11" type="ORF">BWLFYP14_01774</name>
        <name evidence="8" type="ORF">ERS852478_00747</name>
        <name evidence="9" type="ORF">ERS852523_00596</name>
        <name evidence="10" type="ORF">GT728_03905</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">2789STDY5834863</strain>
            <strain evidence="9 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP11610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000016_gene3690"/>
    <dbReference type="EnsemblBacteria" id="CUN66677">
        <property type="protein sequence ID" value="CUN66677"/>
        <property type="gene ID" value="ERS852478_00747"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11610">
        <property type="protein sequence ID" value="CUP11610"/>
        <property type="gene ID" value="ERS852523_00596"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="31"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN66677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP11610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL32361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX64974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="235" mass="26082" checksum="2B994B816956C20D" modified="2016-09-07" version="1">MNNPMILANVKEDFYLNFIKDDRYLWLLDGLKTTLIITVFAVIVGLIIGFLVAIIRSAHDKSGSFKILNAICRVYLTVIRGTPTMIQLLIMNFVIFGAVSINKIIVGGLAFGINSGAYVAEIVRSGIMSIDQGQTEAGRSLGLNFSQTMRLIIIPQAFKNVLPALVNEFIVLIKETSIIGYIGMMDLTKGAMLIQSRTYNAFWPLMAAAAIYLVIVGILTWGMNKLERRLRTSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MC50</accession>
    <name>A0A174MC50_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="16">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 19" type="primary">murB</name>
        <name evidence="20" type="ORF">BWLFYP14_00249</name>
        <name evidence="18" type="ORF">ERS852478_01651</name>
        <name evidence="19" type="ORF">ERS852523_01301</name>
    </gene>
    <organism evidence="19 22">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21 22" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 21">2789STDY5834863</strain>
            <strain evidence="19 22">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="20 23" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="16"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2990"/>
    <dbReference type="EnsemblBacteria" id="CUO02387">
        <property type="protein sequence ID" value="CUO02387"/>
        <property type="gene ID" value="ERS852478_01651"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33884">
        <property type="protein sequence ID" value="CUP33884"/>
        <property type="gene ID" value="ERS852523_01301"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 16" id="KW-0133">Cell shape</keyword>
    <keyword evidence="15 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="8 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0521">NADP</keyword>
    <keyword evidence="13 16 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="17">
        <location>
            <begin position="31"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CUO02387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CUP33884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VUX67408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="303" mass="32892" checksum="C207A542ED30ABAC" modified="2016-09-07" version="1">MNQNIIEKFNDLLGEEKVKVDEPMKRHTTFRIGGPADYFLLPSSEEELSGILKICKNEELPYFILGNGSNLLVSDEGYRGVIIQLYRNYGDITVKGNEIHATAGALLSQIAAAAKNASLTGFEFAGGIPGTLGGAVVMNAGAYGGEMKDVLKEVTVMTAAGEILVLPAEKLEMGYRTSLVKTKGYLVLSAVIVLEQGNQEAIKARMKELTEQRVSKQPLEFPSAGSTFKRPEGYFAGKLIMDAGLRGYQTGGAQVSEKHCGFVINKDNATAADVCRLLRDVQDKVKEQFGVTLEPEVKFLGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174P9B2</accession>
    <name>A0A174P9B2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diaminopimelate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lysA_3</name>
        <name evidence="9" type="synonym">lysA</name>
        <name evidence="9" type="ORF">BWLFYP14_00136</name>
        <name evidence="5" type="ORF">ERS852478_02401</name>
        <name evidence="6" type="ORF">ERS852523_01998</name>
        <name evidence="8" type="ORF">GT712_04455</name>
        <name evidence="7" type="ORF">GT728_02040</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000019">
        <property type="protein sequence ID" value="CUP55420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL32015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704744.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1128"/>
    <dbReference type="EnsemblBacteria" id="CUO30001">
        <property type="protein sequence ID" value="CUO30001"/>
        <property type="gene ID" value="ERS852478_02401"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP55420">
        <property type="protein sequence ID" value="CUP55420"/>
        <property type="gene ID" value="ERS852523_01998"/>
    </dbReference>
    <dbReference type="GeneID" id="66494288"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="4">
        <location>
            <begin position="31"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="3">
        <location>
            <begin position="281"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO30001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP55420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL32015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS88363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="426" mass="47938" checksum="9BA48F7AD5A9A78F" modified="2016-09-07" version="1">MKKVPFVTLDKLQEITAQFPTPFHLYDEKGIRENAKAVKEAFAWNKGFKEFFAVKATPNPFLIQILQEYGCGCDCSSMTELMMSKAIGCKEGDIMFSSNDTPEEEFKYANEIGGIINLDDITHIESVERAVGYIPKVISCRYNPGGVFKISNDIMDNPGDAKYGMTTEQIFEAFKILKEKGAEEFGIHAFLASNTVTNEYYPMLAKEMFEMAVKLQKETGAHVKFINLSGGVGIAYKPDQTPNDIREIGEGVRKVYEEVLVPAGMGDVAIYTEMGRFMMGPYGCLVTKAIHEKHTHKEYIGVDACAVNLMRPAMYGAYHHITVMGKEDQPCDHMYDVTGSLCENNDKFAIDRYLPKVDMGDLLVIHDTGAHGFAMGYNYNGKLKSSEILLHEDGSFEMIRRAETPKDYFATFDCFPIYEKLLEDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174PTQ0</accession>
    <name>A0A174PTQ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bile acid 7-dehydroxylase 1/3</fullName>
            <ecNumber evidence="3">1.17.98.1</ecNumber>
            <ecNumber evidence="6">1.17.99.5</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Glucose 1-dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">baiA1</name>
        <name evidence="6" type="ORF">BWLFYP14_02353</name>
        <name evidence="2" type="ORF">ERS852478_03483</name>
        <name evidence="3" type="ORF">ERS852523_02229</name>
        <name evidence="5" type="ORF">GT712_16510</name>
        <name evidence="4" type="ORF">GT728_16035</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.17.98.1" evidence="3"/>
    <dbReference type="EC" id="1.17.99.5" evidence="6"/>
    <dbReference type="EC" id="1.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000022">
        <property type="protein sequence ID" value="CUP62068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005421611.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000048.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A174PTQ0"/>
    <dbReference type="EnsemblBacteria" id="CUO65740">
        <property type="protein sequence ID" value="CUO65740"/>
        <property type="gene ID" value="ERS852478_03483"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP62068">
        <property type="protein sequence ID" value="CUP62068"/>
        <property type="gene ID" value="ERS852523_02229"/>
    </dbReference>
    <dbReference type="GeneID" id="61851064"/>
    <dbReference type="GeneID" id="67479302"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO65740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP62068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="248" mass="26325" checksum="EB218FD98213C179" modified="2016-09-07" version="1">MRLKDKVAIITGGSRGIGFATADKFLKEGASVVLAASSQESADVAVDKLKEKYPNAIVAGISPNLASMESVRKAFKEATEKYGCVDILVNNAGISENTSFMDYTEETFDKVMDLNVKGVFNTTRVAAECMVARGKGVILSTSSMVSISGQPSGFAYPASKFAVNGLTVSLARELGPKGIRVNAVAPGITETDMMKAVPKEVIEPMIERIPLRRLGQPEDIANAFVFLASDEASYITGVILSVDGMARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WM62</accession>
    <name>A0A173WM62_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00001</name>
        <name evidence="4" type="ORF">GT712_07895</name>
        <name evidence="3" type="ORF">GT728_12635</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN40571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000031">
        <property type="protein sequence ID" value="MZL34024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008702970.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN40571">
        <property type="protein sequence ID" value="CUN40571"/>
        <property type="gene ID" value="ERS852478_00001"/>
    </dbReference>
    <dbReference type="GeneID" id="66492930"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033732571" evidence="1">
        <location>
            <begin position="28"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN40571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="245" mass="27765" checksum="C23E9480A445553F" modified="2016-09-07" version="1">MKKVRLILCSFLALLMMVLTAPVITKAATEPVCLKKATLRYLKWTNYVVDGREKFSTIAWDPLYIGNLSGSAVITNIKSSNKHFTARKGVGVNAIYVEEKPDYVIKDGIKTTISFNVTQNGRTYKLSSRITFKPYGAFFKSFKLGTKDYASDVSGYRLKKMSPLKRNTGKIQITPSNGYKIDEIIVNYPNKSRKVKNGSSISLKNVRKISVWYHTTKKPAYYQNPGKDYRGWTGSPLNYCFDLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WMM5</accession>
    <name>A0A173WMM5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="6">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">coaD</name>
        <name evidence="8" type="ORF">ERS852478_00005</name>
        <name evidence="9" type="ORF">ERS852523_00764</name>
        <name evidence="11" type="ORF">GT712_07875</name>
        <name evidence="10" type="ORF">GT728_12655</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">2789STDY5834863</strain>
            <strain evidence="9 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">BIOML-A1</strain>
            <strain evidence="11 14">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN40763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP16785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000031">
        <property type="protein sequence ID" value="MZL34027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008702978.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1369"/>
    <dbReference type="EnsemblBacteria" id="CUN40763">
        <property type="protein sequence ID" value="CUN40763"/>
        <property type="gene ID" value="ERS852478_00005"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16785">
        <property type="protein sequence ID" value="CUP16785"/>
        <property type="gene ID" value="ERS852523_00764"/>
    </dbReference>
    <dbReference type="GeneID" id="66492926"/>
    <dbReference type="eggNOG" id="COG0669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN40763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP16785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL34027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS88990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="164" mass="18196" checksum="F390D40164C05731" modified="2016-09-07" version="1">MKIAVYPGSFDPATYGHLDVIRRAAVSFDKVIVGVLHNSSKSPLFSVQERVNILEKATRDVPNVEVKPFEGLSVNFARENHAQVIIRGLRAVTDFEYELQMAQTNRVLAPDVDTVFLTTSLEYAYLSSTILKEVAHFGGDLSKFAPAEITDAVIEKIRLTADNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WZ71</accession>
    <name>A0A173WZ71_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methionine gamma-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00140</name>
        <name evidence="3" type="ORF">GT712_00760</name>
        <name evidence="2" type="ORF">GT728_15895</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 5 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A1</strain>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000047">
        <property type="protein sequence ID" value="MZL34635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379972.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44773">
        <property type="protein sequence ID" value="CUN44773"/>
        <property type="gene ID" value="ERS852478_00140"/>
    </dbReference>
    <dbReference type="GeneID" id="66495884"/>
    <dbReference type="eggNOG" id="COG4100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009651">
        <property type="entry name" value="Met_g_lyase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46658">
        <property type="entry name" value="PTHR46658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06838">
        <property type="entry name" value="Met_gamma_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN44773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL34635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS87655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="424" mass="46053" checksum="760EABBD6192CAA8" modified="2016-09-07" version="1">MKEMYAQLGISSEVYDFGHKIEESLKERFEKFDKTAEYNQMKVLLAMQKNKVSAECFGSSSGYGYDDIGRETLEKVYADTFHTEACLVRPQITCGTHALAIALFGNLRPGDELLAPAGKPYDTLEEVIGIRPSKGSLAEYGVSYRQVELLEDGTFDYNSIRKAINEKTRLVEIQRSKGYQTRPSFSVKQIGELISFVKSIKPDVICMVDNCYGEFVDTIEPSDVGADMIVGSLIKNPGGGLAPIGGYIAGTKECVENASYRMTCPGLGSEVGATLGVNRSFFQGFFLAPMVTKGALKGAVFAANIYEKLGFPVIPDSTEPRQDIIQAVSLGTPEGLIAFCKGIQAAAPVDSYVDPEPWDMPGYDSQVIMAAGAFVQGSSIELSADGPMKPPYAVYFQGGLTWEHAKLGVLMSLQKMVDKGLVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X3W8</accession>
    <name>A0A173X3W8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-ribazole phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.73</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Histidine phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobC_1</name>
        <name evidence="2" type="synonym">cobC</name>
        <name evidence="1" type="ORF">ERS852478_00201</name>
        <name evidence="2" type="ORF">ERS852523_00358</name>
        <name evidence="4" type="ORF">GT712_00455</name>
        <name evidence="3" type="ORF">GT728_05990</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
            <strain evidence="2 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">BIOML-A1</strain>
            <strain evidence="4 7">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.73" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000003">
        <property type="protein sequence ID" value="CUP04453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381051.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000025_gene956"/>
    <dbReference type="EnsemblBacteria" id="CUN46383">
        <property type="protein sequence ID" value="CUN46383"/>
        <property type="gene ID" value="ERS852478_00201"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04453">
        <property type="protein sequence ID" value="CUP04453"/>
        <property type="gene ID" value="ERS852523_00358"/>
    </dbReference>
    <dbReference type="GeneID" id="66495823"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043755">
        <property type="term" value="F:alpha-ribazole phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN46383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP04453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS87598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="199" mass="22805" checksum="467C6531B4344030" modified="2016-09-07" version="1">MIKLWLIRHGKTEGNKLSRYIGTTDEPLCQEGTEFLHKMDYPKVQAVYVSPLKRCVQTAEILFPGEPVHIIEELAECDFGEFENKNYKELEGNPHYQEWIDSNGTLPFPGGESREGFKSRNLRGFDRVVSGCIRSHVAEAALVIHGGTIMNIMEEYADIQKPFYEWHVRNGGGYEVELDENLWKNGRKQLRVNSAIMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X498</accession>
    <name>A0A173X498_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">ybeY</name>
        <name evidence="9" type="ORF">BWLFYP14_02663</name>
        <name evidence="8" type="ORF">ERS852478_00165</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052765.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45415">
        <property type="protein sequence ID" value="CUN45415"/>
        <property type="gene ID" value="ERS852478_00165"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN45415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="164" mass="18737" checksum="4ACE7075B678928E" modified="2016-09-07" version="1">MNMQIDYETERELGIDYETLAVKVADKVLEMEKCPYDAQVNLVLTDNEEIERVNTEFRDIARPTDVLSFPMIPFETPAGYDIVEEDESYFDLDTDELLLGDIMISVDKVFAQAEEYGHSVTREFCFLVAHSMLHLLGYDHMTPGEAAVMETKQAKALEELGITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XK57</accession>
    <name>A0A173XK57_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine-protein kinase HipA</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hipA</name>
        <name evidence="5" type="ORF">ERS852478_00360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HipA Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381334.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52242">
        <property type="protein sequence ID" value="CUN52242"/>
        <property type="gene ID" value="ERS852478_00360"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012893">
        <property type="entry name" value="HipA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017508">
        <property type="entry name" value="HipA_N1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13657">
        <property type="entry name" value="Couple_hipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07804">
        <property type="entry name" value="HipA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03071">
        <property type="entry name" value="couple_hipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Couple_hipA" evidence="4">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="HipA_C" evidence="3">
        <location>
            <begin position="158"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN52242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="376" mass="43165" checksum="98ED7361A9D6D73F" modified="2016-09-07" version="1">MREGNALQVFYDEKLVGTLAMTADHKAAFQYSEEWIENGFPISPFSLPLKKQVFVPTKDYFDGLFGVFADSLPDNWGRLLLDRLLRAHKQNPDKLTVLDRLAIVGKSGMGALTYYPEKKIDEQYGDVDLDELAEQCRKILNTEYSDRLDELYRLGGTSGGARPKIMTTVNGEEWIIKFPAHVDGENAGKMEYDYSCCAKKCGIIMSETRLFPSENCEGYFGIKRFDRISDKNGTKRIHMLTAAALLELNFEQPSLDYHSLMKLTKILTRDNKKDMREMFRRMCFNVFAHNRDDHSKNFTYLYNDEKDRWSLSPAYDLTYSNTYYGEHTTTVDGNGRNPGRKELLTVGIAAGMKKEVCIESMDMVEKCVKNMLGRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XMW3</accession>
    <name>A0A173XMW3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative multidrug export ATP-binding/permease protein SAV1866</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852478_00393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199598.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53221">
        <property type="protein sequence ID" value="CUN53221"/>
        <property type="gene ID" value="ERS852478_00393"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="22"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="335"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="367"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN53221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="579" mass="63690" checksum="8BD87C2680286CFA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XN89</accession>
    <name>A0A173XN89_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Maltose acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52710">
        <property type="protein sequence ID" value="CUN52710"/>
        <property type="gene ID" value="ERS852478_00376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN52710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="35" mass="4242" checksum="26234D49DA4B3E1E" modified="2016-09-07" version="1">MTEREKMVSGELYDPTDKELEQFLISPAWMYVKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XPV5</accession>
    <name>A0A173XPV5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjO_3</name>
        <name evidence="7" type="ORF">ERS852478_00418</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53942">
        <property type="protein sequence ID" value="CUN53942"/>
        <property type="gene ID" value="ERS852478_00418"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetI-like"/>
    </dbReference>
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        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN53942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="314" mass="35427" checksum="7821876A93AC331A" modified="2016-09-07" version="1">MKINLKEHLSLTEKRNAKSDLLFSRKRNRRRCAAFRNTQKGLAFILPSFAGVCIFWLIPYVDVIRRSFCGAVNGEFVGIENYRTIFANKAFRLAAGNTLRFFGVCVPLLVVLSLIIAVLLAGQKRFTQILKSFFLLPMAIPVASVVLLWRLLFDDQGLLNHLLHMLSVQTTDWMNTGASFYVLVISYIWRNLGYDVVLWMAGLSAIPAALYEAAKVDGAGEWKCFTKITLPNLLPSLFTIVVLSVLNAFKVFREAYLVAGDYPQEKMYLLQHLFNNWYRDLSLDKMSAAAVVTGLVIFLLILGLWKAWGKGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XQ73</accession>
    <name>A0A173XQ73_9FIRM</name>
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        <submittedName>
            <fullName evidence="3">Maltose-binding periplasmic proteins/domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53884">
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        <property type="gene ID" value="ERS852478_00417"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
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        <property type="entry name" value="SBP"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015589" evidence="2">
        <location>
            <begin position="31"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN53884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="822" mass="89332" checksum="2ECB9E500FDF1C54" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XS00</accession>
    <name>A0A173XS00_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4179 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53716.1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4179" evidence="2">
        <location>
            <begin position="42"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN53716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="350" mass="40177" checksum="A78CCB6F0880C65D" modified="2016-09-07" version="1">MKKDEYSFLELFGNIDDEYIVQALQPWKRQTRRYMVYHIGRKAVCLAFIVMLGLCLAFHDQVHAAVSRFTTMIAEILQISNDLEPYTDVINTTQEKDGISITLNEVILTNNSLLVSVNLDAETEYDGIGISVGESIKINGREYACDSSRVYQKQNLEEKKHQYVVEWIYDEGVPLTKKADIELGIVVHKQIEDMDGETFTFAFSASKEELQKNTVHLNLNQVISLSEGEAVIRDFSINNVTSSLKLESDKFYPEENQYYVEITDMQGDKYRYSLVKKDDKLFTFQNDEDILSSNSEWLDGQIFSLSYAYDAENKDSMDFGTIGSGESEIFKVDFAEMQPVGQKFRIKLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YA52</accession>
    <name>A0A173YA52_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted small molecule binding protein (Contains 3H domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nadR</name>
        <name evidence="4" type="ORF">ERS852478_00595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053022.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60450">
        <property type="protein sequence ID" value="CUN60450"/>
        <property type="gene ID" value="ERS852478_00595"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036094">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR004173">
        <property type="entry name" value="3H_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026043">
        <property type="entry name" value="NadR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40068">
        <property type="entry name" value="PTHR40068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02829">
        <property type="entry name" value="3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037847">
        <property type="entry name" value="NiaR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75500">
        <property type="entry name" value="SSF75500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0533">Nickel</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="3">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="3H" evidence="2">
        <location>
            <begin position="72"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR037847-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN60450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="182" mass="20380" checksum="7C34258F48E5350C" modified="2016-09-07" version="1">MNTAQRRTEILKLLQQAEKPVAARAMASQFGVSRQVIVQDMAVIRASTPGILSTTRGYVLQQDKDIACTREFKVRHGQEQAAEELNLIVDCGGRVKNISISHRVYGRVTAEMDIRSRQDVNEFVQAINSSHSSVLSSATSGYHYHLIEASSQERLDLIGEQLKKAGFLAPLQPWEKEKHHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YBV3</accession>
    <name>A0A173YBV3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage II sporulation protein P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60636">
        <property type="protein sequence ID" value="CUN60636"/>
        <property type="gene ID" value="ERS852478_00600"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010897">
        <property type="entry name" value="Spore_II_P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07454">
        <property type="entry name" value="SpoIIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN60636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="448" mass="50540" checksum="3C77F8E31A785C35" modified="2016-09-07" version="1">MGKHGHRISQEVIHVTNVQKAFCILLSMCFFATLAVLPGTFFTGENVYRHLPLYRFLEKRAHMSSCEDIETYKKIAGENGKYLGERAQSEQLLAEKGESEELQIPESTPVPKETAIPSKTVKSAKISESAKILESEQTSKKSDKTPKPKKITASPENHETDKSQKPQESAAQNDQNIQNSTETIAAAVPHPIIDLSPEKLADYNYLLGQFYIVDSNTEADAVQINAGDFLKQDLKITKETDTPQILIYHSHSQETFADSREGEESDTIVGVGDYLTQLLTENYGYQVVHLKEQFDMAGGELDRSAAYDYARDYLEPYLQENPDIQVIIDLHRDGVPEDRHLVTEINGKPTAQILFYNGLSYTTSKGSLDYLPNPYIQQNLAFSFQLEYQAAQYYPQFYRGIYLAGYRYNLHLRPRSLLLEAGAQTNTVQEVKNAMEPFADILDKVLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YF26</accession>
    <name>A0A173YF26_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199728.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61847">
        <property type="protein sequence ID" value="CUN61847"/>
        <property type="gene ID" value="ERS852478_00634"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN61847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="314" mass="36285" checksum="90957A765FA4C62C" modified="2016-09-07" version="1">MTHKEKYNGTATVDVIIPAYRPGREFGELLHRLEEQEYRPRRILVMNTGEQYWNREWEKCPILEVHHLEQKDFDHGGTRRRAAELSNADIMIFMTQDALPADRKVIGNLVCAVSENPGAGAAYARQLPRADCRFLERYTRSFNYPEQSSVKSLADIDKYGIKTYFCSNVCAAYDKGIYQKTGGFTERAIFNEDMICAGTMIQKGYSVVYAADARVYHSHNYSGKQQFHRNFDLGVSQAEHPEIFEGVPSEGEGIRLVKRSLGYLIRTGHFWLIPQLIWQSGMKYAGYFLGKRYRKLPRKVVLACTMSPYYWNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YKS3</accession>
    <name>A0A173YKS3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable phosphatase YcdX</fullName>
            <ecNumber evidence="2">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycdX</name>
        <name evidence="2" type="ORF">ERS852478_00678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199756.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64309">
        <property type="protein sequence ID" value="CUN64309"/>
        <property type="gene ID" value="ERS852478_00678"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN64309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="240" mass="27225" checksum="71DD4CA9A7435DC9" modified="2016-09-07" version="1">MRYSSVLDLHTHTLVSGHAYCSLREMAKAAADKGLEVLGITEHAPAMPGTCHKYYFENLKIVPREMYGIQLLLGSEVNILDAQGTVDLAQRTLERMDVVIASLHMPCMKPGSKLENTESYLNVMKNPYVNIIGHPDDGRYEIDYEALVQGAKEYGKVLELNNHSMDPECTRENAVENDTVMLELCKKYQVPVVMDSDAHFDLLIGEFDRARDLLEKLDFPEELVLNRSADAIREYVNRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YNU6</accession>
    <name>A0A173YNU6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Penicillin-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">penA</name>
        <name evidence="6" type="ORF">ERS852478_00707</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transpeptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199769.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65250">
        <property type="protein sequence ID" value="CUN65250"/>
        <property type="gene ID" value="ERS852478_00707"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="5">
        <location>
            <begin position="55"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="4">
        <location>
            <begin position="244"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN65250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="611" mass="67717" checksum="EE1C25064A6814EC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YSF5</accession>
    <name>A0A173YSF5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rsgA</name>
        <name evidence="10" type="ORF">ERS852478_00729</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199782.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65975">
        <property type="protein sequence ID" value="CUN65975"/>
        <property type="gene ID" value="ERS852478_00729"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04466">
        <property type="entry name" value="S1_YloQ_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031944">
        <property type="entry name" value="RsgA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16745">
        <property type="entry name" value="RsgA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="65"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="8">
        <location>
            <begin position="74"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="114"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="165"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN65975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="292" mass="33489" checksum="6872F21BAFF9FCFC" modified="2016-09-07" version="1">MQGKIIKGIAGFYYIYAENDEIYECKAKGIFRKDKQKPLVGDNVEIEVLDEQEKEGSVTAILPRKNSLIRPAVANVDQAFVIFAMENPKPNFMLLDRFLIMMEKENVPAVICFNKKDLAKQEELELLYETYKSCGYDVIFSSTFNGEGLDEIREILKGKTTVVAGPSGVGKSSITNALQENVQMETGEISKKLKRGKHTTRHSQVIPVGHDTYLMDTPGFSSLYLTDIEEQELKAYFPEFRRYEEQCRFQGCRHIHEPDCGVKAALAEHKISQLRYEDYLGLYNELKEKRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YT79</accession>
    <name>A0A173YT79_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">fmt</name>
        <name evidence="12" type="ORF">BWLFYP14_01786</name>
        <name evidence="11" type="ORF">ERS852478_00735</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993619.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66255">
        <property type="protein sequence ID" value="CUN66255"/>
        <property type="gene ID" value="ERS852478_00735"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="10">
        <location>
            <begin position="206"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN66255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX64998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="315" mass="34434" checksum="0873904791F991EB" modified="2016-09-07" version="1">MKIVFMGTPDFAVPSLHALTEAGYAVAAVVTQPDKPKGRGKTLLPTPVKEEAVMHDIPVYQPEKVRNNPEFLEILKEINPEIIVVAAYGQIIPKEILELPKFGCINIHASLLPKYRGAAPIQQAVIDGEKVSGVTIQQMGEGLDTGDMISKIVIPISPTETGGSLFGKLAQAGADLLIKTLPSIEQGTAEFEKQPEESPTPYAAMITKQMGLMDFRKSAEELERLVRGLNPWPSAYTFLNGKTLKVWKCKVSTEKTDAVPGTIFLADKEGIHTACGEGVLILTEVQLEGKKRMETEAFLRGYHIENGIVFTDHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YXD5</accession>
    <name>A0A173YXD5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381082.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68872">
        <property type="protein sequence ID" value="CUN68872"/>
        <property type="gene ID" value="ERS852478_00807"/>
    </dbReference>
    <dbReference type="GeneID" id="66493602"/>
    <dbReference type="eggNOG" id="ENOG5032ZTU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN68872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="264" mass="29500" checksum="6351D7BAD1AAED52" modified="2016-09-07" version="1">MRRKNLLKELGIQKQADTSCNALDIDTENIRQRVYAKLDFADTERKQTTMRSKKKILPLLIAATLTIGATAVAATGKISMWTGSSASRADYTSLPTAEQVTKDIGYRPVLIDTFENGYCFKDGNIVKNSFKDDNANVIEKFKSVSFDYQKNGDVVSFEQQKFNSKLTPAGDIIATINGTNLYYVHYINKVVSDDYELTEQDKKDQASGKVVFSYDGSASQIEVSQVQSVNWNKDGIQYDLLQIDGKLSAGELADMAREVINNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YXY9</accession>
    <name>A0A173YXY9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68844">
        <property type="protein sequence ID" value="CUN68844"/>
        <property type="gene ID" value="ERS852478_00806"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033IC7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN68844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="107" mass="11432" checksum="C20547FDA8BD051F" modified="2016-09-07" version="1">MYQTLWNSINKQVKNSHASAAFLAVSLMGWTTIGLLAGFLICMIGGMSFVTKITVVLCSGGYTGLILGFFGGILYLYRSEPHHLADATPSQVSTTSKISLNAKTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z5V1</accession>
    <name>A0A173Z5V1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4 12">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 16" type="primary">murC</name>
        <name evidence="16" type="ORF">ERS852478_00866</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4 12"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199828.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71594">
        <property type="protein sequence ID" value="CUN71594"/>
        <property type="gene ID" value="ERS852478_00866"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 12" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11 12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="13">
        <location>
            <begin position="11"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="15">
        <location>
            <begin position="116"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="14">
        <location>
            <begin position="317"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="118"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUN71594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="459" mass="50313" checksum="1793D5E651206C9B" modified="2016-09-07" version="1">MYQIDFHKPLHIHFIGIGGISMSGLAEILLGEDFVISGSDSKSSPLTQALEKKGATIYYGQRATNITDDVDVVVYTAAIHPDNPEFACAKEKGLPMLTRAELLGQIMRNYDTPVAISGTHGKTTTTSMVSHILLAGDCDPTISVGGILPAIGGNIRVGNSETFVTEACEYTNSFLSFFPKISIILNMDADHLDFFKDIDDIRHSFRRFAELLPADGTLIINADTPKYEDIIRNLPCNVITYGLEHDADYQAADITYDKYGHASFSVLRNGVKVGSYYLKVPGIHNVSNALAAIALGHLLGLSEEVIIKGLGSFTGTDRRFQYKGEVAGVTIIDDYAHHPTEIEATLHAAHNYPHKKLWCVFQPHTYTRTKALLPEFAKALSLADHVVVADIYAARETDTLGISSEDLQKRIQELGTPCEYFPTFDEIENYLLSNCQEGDLLITMGAGDVVNIGEHLLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z7G1</accession>
    <name>A0A173Z7G1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transketolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transketolase 1</fullName>
            <ecNumber evidence="2">2.2.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tktA</name>
        <name evidence="3" type="synonym">tktA_2</name>
        <name evidence="6" type="ORF">BWLFYP14_01232</name>
        <name evidence="2" type="ORF">ERS852478_00847</name>
        <name evidence="3" type="ORF">ERS852523_02498</name>
        <name evidence="5" type="ORF">GT712_07935</name>
        <name evidence="4" type="ORF">GT728_00980</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.2.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000026">
        <property type="protein sequence ID" value="CUP69601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS89000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706915.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000122_gene2854"/>
    <dbReference type="EnsemblBacteria" id="CUN71135">
        <property type="protein sequence ID" value="CUN71135"/>
        <property type="gene ID" value="ERS852478_00847"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP69601">
        <property type="protein sequence ID" value="CUP69601"/>
        <property type="gene ID" value="ERS852523_02498"/>
    </dbReference>
    <dbReference type="GeneID" id="66492975"/>
    <dbReference type="eggNOG" id="COG3959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN71135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP69601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL31806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX64099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="279" mass="30606" checksum="045261F8D7E1C70B" modified="2016-09-07" version="1">MEKLELQKIANEVRKDIVTALHSAKAGHPGGSLSAADVFTYLYFEEMNIDPKDPKKADRDRFVLSKGHTAPGYYSALAERGFFPKEDLKTLRHLGSYLQGHPDMKHIPGVDMSSGSLGQGISAAVGMALSAKLSNESYRVYTLLGDGEIQEGQVWEAAMFAGFRKLDNLVVIVDNNGLQIDGKVDEVCSPYPIDKKFEAFNFHVINVADGNDMDQLRAAFDEAKATKGMPTAIIMKTVKGKGVSFMENQVGWHGKAPNDEQYAQAMEELEKAGEALCQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZBD2</accession>
    <name>A0A173ZBD2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">alaS_1</name>
        <name evidence="5" type="ORF">ERS852478_00925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199848.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73297">
        <property type="protein sequence ID" value="CUN73297"/>
        <property type="gene ID" value="ERS852478_00925"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="4">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN73297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="383" mass="43321" checksum="415778201B0F0EEF" modified="2016-09-07" version="1">MTETRRLYYEDVYKKEFTATVVECREQKKGYAVIVDESAFYPEGGGQPSDVGTLGDAKVTEVHEKDGELLHYTDKALEVGAKVEGKIDWVHRFDLMQQHSGEHMVSGIIHEKYGYDNVGFHMGSDVITVDLNGMLDDSQLSEIEREVNERVWEDREVVITYPDAEELKTIDYRSKKELTGQVRIVTFPGVDVCACCGTHVTHTGEIGMVKLLSVVKFHDGIRMEMICGKRVLDYLNMVNEQNHQISMKLSAKMDRTADAVQRLQDENFRMKGQVARMEEEMFRAESKKWEGAGSVLIFKEGLEADSVRKLADAVMNTCEGCCAVFSRNEDGSYKYAMGEIDGDLRQYTKEMNAALNGRGGGKPFFVQGSVQATEDEIRNFFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZCM3</accession>
    <name>A0A173ZCM3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-3-methyladenine glycosylase</fullName>
            <ecNumber evidence="2">3.2.2.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">alkA</name>
        <name evidence="2" type="ORF">ERS852478_00951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.21" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060623.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74132">
        <property type="protein sequence ID" value="CUN74132"/>
        <property type="gene ID" value="ERS852478_00951"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052822">
        <property type="term" value="F:DNA-3-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052821">
        <property type="term" value="F:DNA-7-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="112"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN74132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="268" mass="31272" checksum="414245862D759740" modified="2016-09-07" version="1">MLTIEMDNFDLGQICRSGQCFRMDQIGDDRYRVIAGDKYLELTQERGIVNFFCPEEDFIFFWIRYFDLDCDYSEYINMINPRDKYLTAAGEMGSGIRILQQDLWEMIISFLISQQNNITRIKKCIENISREFGVRKTSSTGAEYYAFPTAEALALATEEQLRECNLGYRAKYVLDTARKVCFGDISLNSLYDMTYKAARKELLGLYGVGEKVADCICLFGLHQLDAFPVDTHIRQALDAHYKRGFPNRRYKGCRGVMQQYIFYYELMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZM82</accession>
    <name>A0A173ZM82_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione import ATP-binding protein GsiA</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gsiA_7</name>
        <name evidence="5" type="ORF">ERS852478_01027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199884.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76576">
        <property type="protein sequence ID" value="CUN76576"/>
        <property type="gene ID" value="ERS852478_01027"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN76576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="261" mass="28913" checksum="0437A7A5DD1E7DF1" modified="2016-09-07" version="1">MLEIKDLSVRYGKQAPTIEHFNLNMKKGEIISVVGESGSGKTTVIRAVLGALAGGGKVTQGDILFNGKSLLTNTKDEWRQLRGTRISMIFQDCGGTLNPIRKIGSQFVEYICTHSKVSKDEAWKKGVSMLEKMRLPEAENIMNSYPHQLSGGMRQRVGIAMAMTFNPELLLADEPTSALDVTTQAQIVRQMMELRDDFHTGIIIVTHNIGVAAYMADQLIVMQNGKVVDQGTRDEVMNHPTSDYTKKLLAAVPEMEGRRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZMT3</accession>
    <name>A0A173ZMT3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053305.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76920">
        <property type="protein sequence ID" value="CUN76920"/>
        <property type="gene ID" value="ERS852478_01039"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN76920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="297" mass="35774" checksum="613B2D0B10BDAED4" modified="2016-09-07" version="1">MIQNITGVVFIIFHIICCVLVWTGINSHLLKVKRYLILPVIFVPVWGMICVLLLHFQIFFHQDKKREIGIEKMKINEEIYRSIIAPKEESDRNIVPLEEVLLIDEAAMRRDLIMNVLNDDPENYIDMLKQARMNDDVEVVHYAITGMVELSKEYESRLQKIEYRYAKEPENQQLISEYCDFLQEYLSQGLLEGQMELVQRNQYIKLLKKKLKFKEDLHTYVCLTENQMQMKEYEQVLKSLERMDKKWHRNEEYWILRIRYYVELKQGKELKETLEQIQQEHIYLSAKGKEALAFWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZSV1</accession>
    <name>A0A173ZSV1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">YceG-like family</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">YceG-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BWLFYP14_00357</name>
        <name evidence="8" type="ORF">ERS852478_01077</name>
        <name evidence="9" type="ORF">ERS852523_02692</name>
        <name evidence="11" type="ORF">GT712_13560</name>
        <name evidence="10" type="ORF">GT728_14230</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000030">
        <property type="protein sequence ID" value="CUP75382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000037">
        <property type="protein sequence ID" value="MZL34324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000028">
        <property type="protein sequence ID" value="MZS90070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707419.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000035_gene3831"/>
    <dbReference type="EnsemblBacteria" id="CUN79314">
        <property type="protein sequence ID" value="CUN79314"/>
        <property type="gene ID" value="ERS852478_01077"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP75382">
        <property type="protein sequence ID" value="CUP75382"/>
        <property type="gene ID" value="ERS852523_02692"/>
    </dbReference>
    <dbReference type="GeneID" id="66496230"/>
    <dbReference type="eggNOG" id="COG1559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN79314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP75382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL34324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS90070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX67512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="134" mass="14663" checksum="BD90D7340594A36C" modified="2016-09-07" version="1">MSDTRERAGAAGVVVAGTFFKIVLYICVIVLLFWVGKASYQFGHDVFNQQAMSPGEGQEVTVVIKEDTSLYKIAKTLQKKGLVKSATVFYVQERLSTYHGKLQAGTYLLSTAYTPNRIMGILAGDDEQEGVSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZTV6</accession>
    <name>A0A173ZTV6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L(+)-tartrate dehydratase subunit beta</fullName>
            <ecNumber evidence="4">4.2.1.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ttdB</name>
        <name evidence="6" type="ORF">BWLFYP14_00338</name>
        <name evidence="4" type="ORF">ERS852478_01058</name>
        <name evidence="5" type="ORF">ERS852523_04225</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
            <strain evidence="5 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.32" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000093">
        <property type="protein sequence ID" value="CUQ16795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052527.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000144.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000035_gene3850"/>
    <dbReference type="EnsemblBacteria" id="CUN78628">
        <property type="protein sequence ID" value="CUN78628"/>
        <property type="gene ID" value="ERS852478_01058"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ16795">
        <property type="protein sequence ID" value="CUQ16795"/>
        <property type="gene ID" value="ERS852523_04225"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008730">
        <property type="term" value="F:L(+)-tartrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase_C" evidence="3">
        <location>
            <begin position="13"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN78628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUQ16795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX67493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="210" mass="23760" checksum="BC06F1CB89313D2D" modified="2016-09-07" version="1">MIEIRGDKKVLITPISEEDLADIKIGDIVWLDGDLMTCRDVAHRRLVEYGRELPYDIKDKAIFHAGPIVRKIEGTEDDYEMVSVGPTTSMRMEKFEYEFTKLTGVRVIVGKGGMGPNTERACKEFGAIHCVFPAGCAVVAATEVEKIVEHHWDELGMPETLWCNKVKEFGPLIVSIDAQGRNLFEENKVIFNERKEAAKQAIYPEVKFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A4M0</accession>
    <name>A0A174A4M0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">xseA</name>
        <name evidence="9" type="ORF">ERS852478_01163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199944.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82338">
        <property type="protein sequence ID" value="CUN82338"/>
        <property type="gene ID" value="ERS852478_01163"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1570">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="123"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="323"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN82338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="409" mass="46334" checksum="7954540E4E9F8BD8" modified="2016-09-07" version="1">MKNTYSVGQVNRYIKNMFTQDYLLQKIYVKGEVSNCKYHTSGHIYFSLKDETGTLNCVMFAGHRRGLAFAMKNGDKVIVGGSVDVYERDGRYQMYAKEITLEGAGALYERYLALKQELEDMGMFAQEYKQPIPRFIRRLGVVTAPTGAAVQDIRNISYRRNPYLQIILYPALVQGAGAAESIVKGIQMLDKTDVDVIIVGRGGGSIEDLWAFNEEIVARAIFECSTPIISAVGHETDFTIADFAADLRAPTPSAAAELAVDDYRSVIEAVSIYRQRLYRAMSGKMDLYRSRLEHFQTKFAYLSPENRLREQRQRLADLENAVQNGMNRKLQDERHRLSVYLERFAGLSPLKKLNQGYSYVADKYKKTLTSVEQVQNGDTIYISVTDGTIEADVTGTVKEERIYGEERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AFI1</accession>
    <name>A0A174AFI1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Relaxase/Mobilisation nuclease domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199984.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86430">
        <property type="protein sequence ID" value="CUN86430"/>
        <property type="gene ID" value="ERS852478_01245"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005094">
        <property type="entry name" value="Endonuclease_MobA/VirD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03432">
        <property type="entry name" value="Relaxase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN86430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="470" mass="54778" checksum="9A745973A0A75F87" modified="2016-09-07" version="1">MAVCEIWDVRGRLDHPIDYAENPTKTANPKYTEADLQAMVDVMEYATNKNKTEQRFFVTGVNCDPTTARDEMMIAKVQWNDTSEIVCYHGFQSFKHGEVTPEQAHEVGVKLAERMWGDRFQVIVATHLNTDCLHNHFVVNSVSFADGMHYHDNKVNLRLLRQRSDELCREYALSVIEHPSGKKKPYALYQAEKQGRPTRDNVARQAVDEAISKSFTLKDFDRQLAEMGYRINFDPNRKYWTIIGKGWQRPKRLYKLGEEYTNDRIMERIRENSYAVKFQSFSEPQPQVKVYRVKGSLKNAKKIGGLRGLYLHYCYKLGILPKGRKQNYARLHYLLKDDLMKMEAITQETRLLCRNHIDTAEQLCSYKGSLETEMSALLQKRKELYSKSRRISGEEKEAVKAELSDISGRLKIIRKEVRMCEGIAARSDTLKEKLQTIRADEHEQQRKELMKNEHRRRSGRTNRPNELGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AKD4</accession>
    <name>A0A174AKD4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall-binding protein yocH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yocH</name>
        <name evidence="3" type="ORF">ERS852478_01300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380751.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88349">
        <property type="protein sequence ID" value="CUN88349"/>
        <property type="gene ID" value="ERS852478_01300"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010611">
        <property type="entry name" value="3D_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06725">
        <property type="entry name" value="3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017749" evidence="1">
        <location>
            <begin position="39"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="3D" evidence="2">
        <location>
            <begin position="319"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN88349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="379" mass="40665" checksum="14A2AD8D33C10336" modified="2016-09-07" version="1">MIGQTERDDKGVEAQFMKKKILALLVCSMLTLSTTVSADILDYEGTINAYKQDDKTPQTFEIDNGSGEKVTAVAKSDKVSVSAKATYIRSMPGKNGKKLARVYLGTGVERVAVCDNGWSKVTYEKKGKKGTEKISGYVPTKHINDSDQVAQARGTFTALKDSDILDYPGKKDGQIVGEVIQEDEVKRLATVNGIWSQIYYKKENGKRGIGYIPTSVLENTAAEENTEESKVAKVDGEEAGTIHKSEGKGVFAEAVDGVTASKGEPVDGVKVGTPVAVSSDASLVPLGTFKITHYCPCSICCGPWANGITSTGVTATTNRTIAVDPTQIPYGSKVVINGQVYVAEDCGGAIKHNCIDIYVATHQEGEDKGVYYTDVYLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AMM8</accession>
    <name>A0A174AMM8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200009.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88870">
        <property type="protein sequence ID" value="CUN88870"/>
        <property type="gene ID" value="ERS852478_01316"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN88870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="200" mass="22250" checksum="56FEA04371D164C8" modified="2016-09-07" version="1">MSVTNNGKQKRNKKKKRLIKLLIIVIILFILLMLAGTLLLQHRKNVDREQRKAEAIAALERVPTVTPTPAATPTPTPTPIPTATPTPVLERAYVFNPEDYLGTWRSKNGRVKIKIKKLSQKSVTFTYSQTNKKKTATCKAKVKKSVAGNATRFSFTDSLGNVAKGYLTFDNGRLYVNIKTKTKAEGAKVHPSVDTVMIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B2R0</accession>
    <name>A0A174B2R0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200085.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94026">
        <property type="protein sequence ID" value="CUN94026"/>
        <property type="gene ID" value="ERS852478_01438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN94026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="341" mass="37951" checksum="7155551563097097" modified="2016-09-07" version="1">MRNTTAGIKAEIAKGVFRPHTALTNMALAYYQNASNYFAKALFPTCPVGLSSDNYYIFSREDLLRDNWQRKPAYGKVDPTTIGESTDNYVCKVDQMIMGIDQIRQTDLSRRQGPSIIQPKQQRTRTIAEQANIHQDRLFAASYFKEGAWKNELEGVDNTTPSTNQFIKFSNANSDPIAFIDKEKTDMNQQTGRMPNRLGLGINVFNALKVHPGILERVKYGGSTANPASVTENVLAQLFGVEKIVVLKSIMNSASMGADEDMQYIGDPNAFLLAYATNTPSIDEPSAGYIFTWDMLGNGQMLPILNYLGENGTHTEYIEGLMATDMKKTSDDLARFYKAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BB31</accession>
    <name>A0A174BB31_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200140.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97987">
        <property type="protein sequence ID" value="CUN97987"/>
        <property type="gene ID" value="ERS852478_01548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025468">
        <property type="entry name" value="TTRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041965">
        <property type="entry name" value="TTRAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14203">
        <property type="entry name" value="TTRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN97987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="66" mass="7514" checksum="8CAE0B49B77D9532" modified="2016-09-07" version="1">MYFTVEEENLICLYHNADRRRTAANLRAALPDMDKEMAALACQTADKLDTMSDADFAAQRSHFTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BG19</accession>
    <name>A0A174BG19_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ssb_1</name>
        <name evidence="5" type="ORF">ERS852478_01582</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_054335695.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99972">
        <property type="protein sequence ID" value="CUN99972"/>
        <property type="gene ID" value="ERS852478_01582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN99972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="132" mass="15030" checksum="48AD7C0EBA74F961" modified="2016-09-07" version="1">MNTTVISGRLVRNPGYNEVENEKGLHKIAKFVLAVRRNYSDEVSFIPVKAFAKKAEFARDYLIQGTKVMVEGEIVTGNYEDKDTGKKIYTTEVYANRIEFAGAKMVDRPPFPEDAEGFLEIPEGMEEEMPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BHH6</accession>
    <name>A0A174BHH6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bifunctional folylpolyglutamate synthase/dihydrofolate synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="8">6.3.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fgs_1</name>
        <name evidence="8" type="ORF">ERS852478_01571</name>
        <name evidence="9" type="ORF">GT712_09075</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707224.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99629">
        <property type="protein sequence ID" value="CUN99629"/>
        <property type="gene ID" value="ERS852478_01571"/>
    </dbReference>
    <dbReference type="GeneID" id="66496102"/>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="7">
        <location>
            <begin position="44"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="6">
        <location>
            <begin position="294"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN99629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="432" mass="47713" checksum="CE3AF2BC214FA1D1" modified="2016-09-07" version="1">MNYEEAVAYIDETPKFTKKNSLDHTKECLRRLGNPQDKFKVIHVAGTNGKGSTCAFLTSVLREAGYSCGLFTSPHLVEINERFQINEVNIDNDTFLKAFEKVKVLADELVAEGSYHPTYFEMLFLMGMVIFAEAGVDYVTLETGLGGRMDATTAVENPVACVITSISLDHMQYLGDTVAKIAGEKAGIIVPGVPVIYDGNDPDAAEVIRARAEELGSPAYEVKRSDTEVLRNTSAGIDFAFRNEYYKDMVFSIPFIAKYQVMNSALALKTIEVLQNVISVSMDQIHVGIAGTRWQGRMETVLPGVIVDGAHNEDGVEKFVETAEHFQKECPLTLLFSAVDDKDYTDMIHTICSRITFRQVVVTSVGGYRQVPAERFAKLFTEAGASSVEVVEDVEKAFGRALEVKGDDGMLFCVGSLYLVGEIKDVIRRNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BIW3</accession>
    <name>A0A174BIW3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">valS</name>
        <name evidence="15" type="ORF">BWLFYP14_00234</name>
        <name evidence="13" type="ORF">ERS852478_01569</name>
        <name evidence="14" type="ORF">GT712_09085</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="14 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579947.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99556">
        <property type="protein sequence ID" value="CUN99556"/>
        <property type="gene ID" value="ERS852478_01569"/>
    </dbReference>
    <dbReference type="GeneID" id="66496100"/>
    <dbReference type="eggNOG" id="COG0525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="18"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="609"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="12">
        <location>
            <begin position="820"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="816"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="526"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN99556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS89222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VUX67393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="884" mass="101901" checksum="A9877107D7FABE1A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BJS0</accession>
    <name>A0A174BJS0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00469">
        <property type="protein sequence ID" value="CUO00469"/>
        <property type="gene ID" value="ERS852478_01597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO00469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="46" mass="5722" checksum="AEA503524D52F957" modified="2016-09-07" version="1">MMKAMEKRQEARKNQEKTLKRMMAYQKKAEQMISRKRMNHHMIRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BNH9</accession>
    <name>A0A174BNH9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage V sporulation protein AC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052570.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPB010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02314">
        <property type="protein sequence ID" value="CUO02314"/>
        <property type="gene ID" value="ERS852478_01649"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031DDD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005562">
        <property type="entry name" value="SpoVA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38450">
        <property type="entry name" value="PTHR38450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03862">
        <property type="entry name" value="SpoVAC_SpoVAEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO02314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="154" mass="16548" checksum="8065EF6BC4F81F39" modified="2016-09-07" version="1">MSDNNLSQKKQKQYEEYVKAVTPVHSLPLNMCKAFFTGGVICVVGQVILNYADTLGLDKDTAGSWCSLILILFSVILTGCNLYSKIGRFGGAGSLVPITGFANSVASSAIEYKAEGQVFGIGCKIFTIAGPVILYGILSSWILGVIYYLFTMIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BYD8</accession>
    <name>A0A174BYD8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress response protein SCP2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TerD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yceC</name>
        <name evidence="6" type="ORF">BWLFYP14_01161</name>
        <name evidence="3" type="ORF">ERS852478_01725</name>
        <name evidence="5" type="ORF">GT712_12230</name>
        <name evidence="4" type="ORF">GT728_09970</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">BIOML-A1</strain>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAPAB/TerDEXZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000020">
        <property type="protein sequence ID" value="MZL33514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705352.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05637">
        <property type="protein sequence ID" value="CUO05637"/>
        <property type="gene ID" value="ERS852478_01725"/>
    </dbReference>
    <dbReference type="GeneID" id="66492349"/>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO05637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX63802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="202" mass="22075" checksum="0B12F9BBAA8BC36F" modified="2016-09-07" version="1">MSVSLQKGQKVNLSKEHAGLAKVIVGLGWDEAKPSGGGGLFGALFGSSSHQAIDCDASAIMLKNGKFTDKTDLVYFGNLKHKSGTVNHMGDNLTGAGEGDDEQIVIDLSRVPAEYDKIVIVVNIYQAVKRKQHFGMIQNAFIRLVDARNNKEMCKYNLTENYSGMTAMIFGEIYRYNGEWKFNAVGNGTTDPGLGELCQRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BZC2</accession>
    <name>A0A174BZC2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06581">
        <property type="protein sequence ID" value="CUO06581"/>
        <property type="gene ID" value="ERS852478_01756"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033N1P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO06581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="115" mass="13598" checksum="32C29523E3D3F7B6" modified="2016-09-07" version="1">MVTDRQILEAVLTEVRGFGTRMDKFESRMDKFESQMDRMEERQKCFEEETRNNFADIRLHLENITDRNISILAENHLNLINKMDVSATWMNRIMINEVKMNALTDQVARLQAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CAR1</accession>
    <name>A0A174CAR1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative electron transport protein yccM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yccM_3</name>
        <name evidence="8" type="ORF">ERS852478_01830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08955">
        <property type="protein sequence ID" value="CUO08955"/>
        <property type="gene ID" value="ERS852478_01830"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="267"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO08955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="303" mass="33822" checksum="42E9F9CB0B901EF3" modified="2016-09-07" version="1">MSNKKNSDNKSNKKQNTKNMKINEWPRHGIQALWAFITNSHVTGFVTGKIYTGKLKNACVPGLNCYSCPGAVGACPIGSLQAVIGSWNFKMAYYVVGFLIFIGAMVGRLICGFLCPFGLIQDLLNKIPFPKKIRTFKGDKLLRKLKYVIFAVFVILLPLFLVDIMGQGAPYFCKLICPAGTLEGGLPLVLLNKSMRSALGWLYIWKNVILVITIILSILIYRPFCKYICPLGAFYSVFNPVSLYKYRVDKDKCIKCGKCAKACQMIVDPVENSNSPECIRCGRCRKVCPTDAIQCGIRRKPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CCI1</accession>
    <name>A0A174CCI1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nrdB</name>
        <name evidence="6" type="ORF">ERS852478_01865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 5">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="3 5">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200383.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10763">
        <property type="protein sequence ID" value="CUO10763"/>
        <property type="gene ID" value="ERS852478_01865"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000355">
        <property type="entry name" value="NrdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO10763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="347" mass="40664" checksum="E386B88F35C01118" modified="2016-09-07" version="1">MTELKKKPLFNPEGDLNVRLRRMIGGNTTNLNDFNNMKYVWVSDWYRQAMNNFWIPEEINLSQDVKDYPRLLSAERSAYDKILSFLVFLDSIQTANLPNIGAYITANEVNLCLSIQAFQECVHSQSYSYMLDTICSPVERNDILYQWKTDEHLLRRNTFIGDCYNEFQERKDAPSLLRVMMANYILEGIYFYSGFMFFYNLSRNGKMPGSAQEIRYINRDENTHLWLFRNIITELQKEQPELFTAESVQALREMMHEGVEQEIAWGHYVIGDDIPGLNRQMISDYIRYLGNLRWTSLGYPALYPGFESEPESMEWVSQYADANMVKTDFFEARSTAYAKSTALIDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CGQ3</accession>
    <name>A0A174CGQ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XRE family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01885</name>
        <name evidence="3" type="ORF">GT712_19090</name>
        <name evidence="2" type="ORF">GT728_21465</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 5 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A1</strain>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000133">
        <property type="protein sequence ID" value="MZL35656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000069">
        <property type="protein sequence ID" value="MZS91084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053640.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000133.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11359">
        <property type="protein sequence ID" value="CUO11359"/>
        <property type="gene ID" value="ERS852478_01885"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO11359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL35656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS91084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="171" mass="19374" checksum="3912C487A25491BF" modified="2016-09-07" version="1">MGKQSTRENKTIYQLCREAAGLTRAEASEKMDAVSASKIEKFEYETQEPTPYDILQMADAYKRPDLCNYYCSHKCEIGQRYVPEVEVTNLSNIILETIASLNEINPLTGRLIQIARDGKISDDEMKDFAYISKKLDEISLAIDSLNLWVDKTAGEQGLNLELLNAEKTKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CGV8</accession>
    <name>A0A174CGV8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">EIIABC-Fru</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">fruA</name>
        <name evidence="16" type="ORF">ERS852478_01930</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200446.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12841">
        <property type="protein sequence ID" value="CUO12841"/>
        <property type="gene ID" value="ERS852478_01930"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022877">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05569">
        <property type="entry name" value="PTS_IIB_fructose"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036095">
        <property type="entry name" value="PTS_EIIB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013011">
        <property type="entry name" value="PTS_EIIB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003501">
        <property type="entry name" value="PTS_EIIB_2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013014">
        <property type="entry name" value="PTS_EIIC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004715">
        <property type="entry name" value="PTS_IIA_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003353">
        <property type="entry name" value="PTS_IIB_fruc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006327">
        <property type="entry name" value="PTS_IIC_fruc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02302">
        <property type="entry name" value="PTS_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52794">
        <property type="entry name" value="SSF52794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00829">
        <property type="entry name" value="FRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00848">
        <property type="entry name" value="fruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01427">
        <property type="entry name" value="PTS_IIC_fructo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00372">
        <property type="entry name" value="PTS_EIIA_TYPE_2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51099">
        <property type="entry name" value="PTS_EIIB_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51104">
        <property type="entry name" value="PTS_EIIC_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-2" evidence="13">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-2" evidence="14">
        <location>
            <begin position="173"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-2" evidence="15">
        <location>
            <begin position="297"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUO12841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="637" mass="66303" checksum="B0536A2BBC19AA0C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CIM0</accession>
    <name>A0A174CIM0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Xaa-Pro dipeptidase</fullName>
            <ecNumber evidence="5">3.4.13.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pepQ</name>
        <name evidence="6" type="ORF">BWLFYP14_02194</name>
        <name evidence="5" type="ORF">ERS852478_01939</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="6"/>
    <dbReference type="EC" id="3.4.13.9" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200459.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13083">
        <property type="protein sequence ID" value="CUO13083"/>
        <property type="gene ID" value="ERS852478_01939"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102009">
        <property type="term" value="F:proline dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="3">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="2">
        <location>
            <begin position="312"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24_C" evidence="4">
        <location>
            <begin position="535"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO13083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="595" mass="67063" checksum="2C01C55AC4BE2292" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CLC6</accession>
    <name>A0A174CLC6_9FIRM</name>
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        <submittedName>
            <fullName evidence="4">Regulatory protein BlaR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">blaR1_3</name>
        <name evidence="4" type="ORF">ERS852478_01958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703601.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13687">
        <property type="protein sequence ID" value="CUO13687"/>
        <property type="gene ID" value="ERS852478_01958"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="3">
        <location>
            <begin position="8"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO13687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="582" mass="65282" checksum="66BD8C946B0F2F0D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CUE7</accession>
    <name>A0A174CUE7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707522.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15236">
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        <property type="gene ID" value="ERS852478_01984"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032U3A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019496" evidence="2">
        <location>
            <begin position="32"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO15236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="566" mass="60635" checksum="DB74180CD4B431AE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D6N9</accession>
    <name>A0A174D6N9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21291">
        <property type="protein sequence ID" value="CUO21291"/>
        <property type="gene ID" value="ERS852478_02156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019773" evidence="3">
        <location>
            <begin position="38"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO21291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="715" mass="79750" checksum="113CAE69103CCBCB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D8D2</accession>
    <name>A0A174D8D2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4340 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200604.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21891">
        <property type="protein sequence ID" value="CUO21891"/>
        <property type="gene ID" value="ERS852478_02176"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025641">
        <property type="entry name" value="DUF4340"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14238">
        <property type="entry name" value="DUF4340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019808" description="DUF4340 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4340" evidence="3">
        <location>
            <begin position="76"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO21891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="547" mass="60469" checksum="CBF3567B64F5478A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DGP6</accession>
    <name>A0A174DGP6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conjugative transposon protein TcpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200645.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24593">
        <property type="protein sequence ID" value="CUO24593"/>
        <property type="gene ID" value="ERS852478_02248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16428">
        <property type="entry name" value="TcpC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024735">
        <property type="entry name" value="TcpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035628">
        <property type="entry name" value="TcpC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12642">
        <property type="entry name" value="TpcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO24593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="300" mass="33870" checksum="D374AAD025D1EEB2" modified="2016-09-07" version="1">MFKKNKKQTENIKEKKVRTVKVGTHQKTVIALWAVLIASVSFGAYKNFTAIDQHTTHEKEIIELRLQDTNGIENFVKNFAKSYYTWSNSKEAIEARTQAINSYLTKELQDLNVDTIRTDIPTSSTVTDVLVWNIEQSGTDTFSATYEVDQQIKEGEQTSNVKATYTVKVHVDADGDMVIVQNPTLAPAIEKSDYEPKTPEADASVDADTVNDATAFLETFFKLYPTATQKELAYYVSGNVLEPIGRDYLYSELVNPVFTKDGDNVKVKVAVKFLDNQTKATQVSQYELVLHKDSNWKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DIC7</accession>
    <name>A0A174DIC7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005428606.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000138.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24957">
        <property type="protein sequence ID" value="CUO24957"/>
        <property type="gene ID" value="ERS852478_02260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO24957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="60" mass="6886" checksum="9FB7874465E74498" modified="2016-09-07" version="1">MKDKNILICVGIIIYIAMSGIDRFVYHIPNIIYIPVAILGIALILIGFFKDKFKQENFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DN97</accession>
    <name>A0A174DN97_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BMC domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Propanediol utilization protein PduU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pduU_1</name>
        <name evidence="4" type="synonym">pduU_2</name>
        <name evidence="7" type="ORF">BWLFYP14_01575</name>
        <name evidence="3" type="ORF">ERS852478_02330</name>
        <name evidence="4" type="ORF">ERS852523_01611</name>
        <name evidence="6" type="ORF">GT712_12715</name>
        <name evidence="5" type="ORF">GT728_12320</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO27091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP43680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000029">
        <property type="protein sequence ID" value="MZL33964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705594.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000126_gene3814"/>
    <dbReference type="EnsemblBacteria" id="CUO27091">
        <property type="protein sequence ID" value="CUO27091"/>
        <property type="gene ID" value="ERS852478_02330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP43680">
        <property type="protein sequence ID" value="CUP43680"/>
        <property type="gene ID" value="ERS852523_01611"/>
    </dbReference>
    <dbReference type="GeneID" id="66494446"/>
    <dbReference type="eggNOG" id="COG4810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009307">
        <property type="entry name" value="EutS/PduU/CutR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40449">
        <property type="entry name" value="PTHR40449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="70"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO27091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP43680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL33964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS89909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX64721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="142" mass="15736" checksum="9E38E034CD280E22" modified="2016-09-07" version="1">MAGMTTRELLEKLYNQDYEKLKGKKLRMTRVRVPGKEVCLAHVINPSQSCIYQNLGLHIGVHEGEDHTGEAIGMIRFTPWEAVVVAADIAVKSANVEIGFMDRFSGSLILTGGLTEVQTAVEEVVKFFREVLGFKTCAVHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DPJ7</accession>
    <name>A0A174DPJ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable endopeptidase cgR_2070</fullName>
            <ecNumber evidence="6">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_02332</name>
        <name evidence="7" type="ORF">ERS852523_01609</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
            <strain evidence="7 9">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO27147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP43641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381074.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000126_gene3812"/>
    <dbReference type="EnsemblBacteria" id="CUO27147">
        <property type="protein sequence ID" value="CUO27147"/>
        <property type="gene ID" value="ERS852478_02332"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP43641">
        <property type="protein sequence ID" value="CUP43641"/>
        <property type="gene ID" value="ERS852523_01609"/>
    </dbReference>
    <dbReference type="GeneID" id="66494448"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3883">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014251108" evidence="4">
        <location>
            <begin position="25"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="364"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="48"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="275"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO27147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP43641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="478" mass="52939" checksum="F43166B38A2C4C01" modified="2016-09-07" version="1">MKKRIVCLTLALLMSATQVVSVSASREDELREEQAITSQQLDATYSRMDELAYAKSQLENEISELDSNLVSVMVSIDTLKGDIDNKEVDIIKTKQDLAKAQKARDKQYESMKLRIQALYEQGGDAAWFQMMLNSEDLSELLTRAENTQQMYEQDRKNLDKYVNTINEVNNLKTQYESDKAELEEMKASYEQQSYDLQCQIDQKKSESADYENEIAYAQQQATEYANLLAEQTAEIQRLEAERIAAEEEARRQAEEEAARQAAEEEAAAKAAEQEQDSESEEEENVEYDEDGNEIENTDDADDESESDDGVEYDENGDPVDNAGASDDVEYDEYGNVIDSDNTVSPDDYESEQSSDSDSSSSSGSGSGSSVVDFATQFVGNPYVWGGTSLTGGADCSGFTQSVYANFGVSLPRTSYEQQNAGTEVSYADAQPGDLICYGGHVAIYMGNGRIVHASNSVDGIKISDNAAYRTIVSVRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E0B5</accession>
    <name>A0A174E0B5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Methionine import ATP-binding protein MetN 2</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">metN2</name>
        <name evidence="6" type="synonym">metN2_1</name>
        <name evidence="5" type="ORF">ERS852478_02385</name>
        <name evidence="6" type="ORF">ERS852523_02014</name>
        <name evidence="8" type="ORF">GT712_04555</name>
        <name evidence="7" type="ORF">GT728_02115</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
            <strain evidence="6 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">BIOML-A1</strain>
            <strain evidence="8 11">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000019">
        <property type="protein sequence ID" value="CUP55729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL32029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380585.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1114"/>
    <dbReference type="EnsemblBacteria" id="CUO29520">
        <property type="protein sequence ID" value="CUO29520"/>
        <property type="gene ID" value="ERS852478_02385"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP55729">
        <property type="protein sequence ID" value="CUP55729"/>
        <property type="gene ID" value="ERS852523_02014"/>
    </dbReference>
    <dbReference type="GeneID" id="66494273"/>
    <dbReference type="eggNOG" id="COG1101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO29520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP55729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL32029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS88382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="264" mass="29026" checksum="D9D82AF81FF93BF4" modified="2016-09-07" version="1">MLKIEHISKTFNPGTVNEKQAIRDLSLNLEKGDFATIIGSNGAGKSTLFNAICGDFLTDSGVIMLDGQDITFMPQHVRAKTIGRLYQDPMRGTAPGMTIEENLALAAGKGGWLSHVSRQEKERFHEELKLLDIGLEKRMTQPVGLLSGGQRQALTLLMATMNPPKLLLLDEHTAALDPGTAEKVLNLTKRIVEEHQLTCLMITHNMQSALDLGNRILMMDSGDIVLDIHEEEKKGLTVEGLLEKFKTGAGKMLDNDRILLSGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E439</accession>
    <name>A0A174E439_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02144</name>
        <name evidence="2" type="ORF">ERS852478_02476</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994000.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32672">
        <property type="protein sequence ID" value="CUO32672"/>
        <property type="gene ID" value="ERS852478_02476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO32672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="174" mass="19592" checksum="75A9458677D9DE80" modified="2016-09-07" version="1">MKITKLSRRQTQIIVITAGLLLFLITIVYSVKTDIKAVARQMDETLKYVKEQCYIYNRYNEASQTKGLMRAIENAQQVNRNLTHTKDEVTKDKLKTYAASIVLEDGSQVDLAAYGRSDEKGIIITFYHTSAEYARNYNLTIQSLLSGYDTYSSGMIVVTDGKNVVASNDENLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E7E2</accession>
    <name>A0A174E7E2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02152</name>
        <name evidence="2" type="ORF">ERS852478_02468</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703642.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32478">
        <property type="protein sequence ID" value="CUO32478"/>
        <property type="gene ID" value="ERS852478_02468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO32478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="296" mass="34024" checksum="0C7B2B011DD8C141" modified="2016-09-07" version="1">MRQVFGIVRYNFFGFLRNPKVIFIFLLEFVLSFLLTGRIMVVMETYDTPVQAIEPFIWTFGDGIAVLSSSLLLLLMFSDLPKMTPITPYQLTRTTKRKWLLGQFIYVILVTVLYTVLMLLFTAVLCMKKSYPGNLWSETAAMLGYSELGKNLQVPSTVRVMESISPYGCMLQVFFLLFCYSLTLSFVILVGNLYKGKTKGMIFGLLYSVFVFLLDPKVLAAILHKEKYEMYQVNVLICWISPLNQAVYGKHNLGYDPLLPKISHSYMFFLGILVLLAVFAINRMKKYTFEFLGEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EDS3</accession>
    <name>A0A174EDS3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">ABC-type uncharacterized transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_00525</name>
        <name evidence="2" type="ORF">ERS852478_02530</name>
        <name evidence="3" type="ORF">GT728_13385</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO34060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000033">
        <property type="protein sequence ID" value="MZL34169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000004">
        <property type="protein sequence ID" value="VUX62661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703741.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34060">
        <property type="protein sequence ID" value="CUO34060"/>
        <property type="gene ID" value="ERS852478_02530"/>
    </dbReference>
    <dbReference type="GeneID" id="66495281"/>
    <dbReference type="eggNOG" id="COG2984">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06325">
        <property type="entry name" value="PBP1_ABC_unchar_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007487">
        <property type="entry name" value="ABC_transpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35271">
        <property type="entry name" value="PTHR35271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04392">
        <property type="entry name" value="ABC_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033732191" evidence="1">
        <location>
            <begin position="26"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO34060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX62661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="328" mass="34297" checksum="BBA032ADCA3F6AB1" modified="2016-09-07" version="1">MKRKALAITLAAAMAMGTCAVTASAADGDKYTIGICQLVQHEALDAATQGFKDEVTKELGEDAVTFDEQNAQGDSNTCSTIINSFVSNNVDLILANATPALQAAAAGTSDIPILGTSVTEYGVALGLDDFDGTVGGNISGTADLAPLDQQAAMLNELFPDAKNVGLLYCSAEANSQYQVDTVKAELEKLGYTCEYYAFSDSNDLSSVATTATDASDVIYVPTDNTVASNTEIINNICLPAKVPVITGEEGICSGCGVATLSISYYDLGVTTGKMAVKILKDGEDISTMPIEYAPNFTKEYNKDICEELGIEVPDDYVAIGEAAEETAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EIK4</accession>
    <name>A0A174EIK4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO37724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060104.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000055.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37724">
        <property type="protein sequence ID" value="CUO37724"/>
        <property type="gene ID" value="ERS852478_02624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO37724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="202" mass="23923" checksum="D6985CAB90C40F34" modified="2016-09-07" version="1">MANNTIFDNVFRTMLEKMPELVVPLINEVFGTNYPADIAVEQQRNEHQTKNGEKITDSRLKIADKIYHIECQSTGDAEMVIRMIEYDFAVSLETKQIENGRYKIYFPHSCVLYLRGKGRKDTLGMDIIMPDGRVIKYELPAIYIERYTQDVIFQKKLLFFLPFYVMRYEKSREDIEKDPEKLQKLLDEYVTISRRLEESLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EIK9</accession>
    <name>A0A174EIK9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380768.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36055">
        <property type="protein sequence ID" value="CUO36055"/>
        <property type="gene ID" value="ERS852478_02579"/>
    </dbReference>
    <dbReference type="GeneID" id="66494134"/>
    <dbReference type="eggNOG" id="COG1410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO36055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="261" mass="28433" checksum="E4A6943C26083AA3" modified="2016-09-07" version="1">MAKFVTIGERLSTTAPAVNKAFTERDPEPIIKRAKQQLDAGATYLDVNIGPAENDGEDLMKWAVQLLQSEFDNVPLALDTTNQKAIEAGISVYNRAKGKPIVNSADAGDRISNIDLAAANDAICIALCSSGMVAADNDERMMHCQNMLERGMAQGMDTEDLWFDPLFLVVKGMQDKQMEVLEAIKMFSEMGLNSTGGLSNNSNGMPKHIRPIMDSALVAMAMMNGLTSAIVNPNDLRLMETIKSCDVFKGNTLYADSYLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EJF7</accession>
    <name>A0A174EJF7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione import ATP-binding protein GsiA</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Oligopeptide transport ATP-binding protein OppF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_8</name>
        <name evidence="7" type="synonym">oppF_1</name>
        <name evidence="7" type="ORF">BWLFYP14_00898</name>
        <name evidence="6" type="ORF">ERS852478_02635</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993320.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38004">
        <property type="protein sequence ID" value="CUO38004"/>
        <property type="gene ID" value="ERS852478_02635"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO38004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX63420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="303" mass="34507" checksum="5FFFA7ED3041A501" modified="2016-09-07" version="1">MSKEILLDVRHLTQQFHLTKKIKVKAVDDVSFQIHKGEIFGLVGESGSGKSTVARCLMNIYQPAQGEIWYKDVNICDKKEFKKHKKMLQTRRQMIFQDSASSLNQKMKVSDIITEPMRIQHITPPRGSFVKEAAFQMEYVGLENSFLDRYPSELSGGQRQRVAIARSLCMEPEFLVADEPIASLDVSIQAQIVNLFRHLQEEHGFTFLFIAHDLAMVEYLCDRVGVMYHGKLVELAPSEELYSNPVHPYTKTLLSAIPVPDPIRERKRVLQYYDGEGMENSVWTEVSPGHFAMLPAEGKGCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EL54</accession>
    <name>A0A174EL54_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_00916</name>
        <name evidence="2" type="ORF">ERS852478_02653</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993324.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38543">
        <property type="protein sequence ID" value="CUO38543"/>
        <property type="gene ID" value="ERS852478_02653"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033PC0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO38543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX63438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="408" mass="48449" checksum="2C4327F0C1702AC9" modified="2016-09-07" version="1">MKEQQEKIRVLDPHIILILFISAFVFGIGILMIFLERKEIRTEGYEFIIFSVEILMLLLILYYMRTVVLSREGCTVSWLFWKRNYKWEELAVIREDVWYTYGKGGSIRYQGIVFSKYAVNKKKKKYTTRMIVDAFPLSDCFYITFDEHGNVFSYKLEKGKKQVIRKMYVNVREKMKEWGVEAEKGEGIKEEEKQRQYDEMIELRRQQRKKIQSKGADCTNLKEYQQEVIKIRYFLQITMVILITVLLIWTGLSAEEGERIPILILEFLIDAPLLFFSSKVVTLSKEGCKISYLFFKKMYKWEELEIIREDYFPSFRDRRSRGIVFSKRKKNKAGYIYTTREIVGSGHILECFYIVLDADGNIHLYKRLAAKDGKTKLRKVAVNIPQKLAEWGVEMEKMMKYTGGTYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EQD6</accession>
    <name>A0A174EQD6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="7">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">tilS</name>
        <name evidence="9" type="ORF">ERS852478_02703</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200846.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40342">
        <property type="protein sequence ID" value="CUO40342"/>
        <property type="gene ID" value="ERS852478_02703"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012796">
        <property type="entry name" value="Lysidine-tRNA-synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11734">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00977">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02433">
        <property type="entry name" value="lysidine_TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TilS_C" evidence="8">
        <location>
            <begin position="404"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="26"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO40342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="485" mass="56063" checksum="F093F3C115141662" modified="2016-09-07" version="1">MEREILAYIKQNRMIGKNDVVLAGVSGGSDSMAMLRILKELQGKLDFTLRVVHIHHGIRGKEADRDQSFVENICRKWQIPCTVYCYDVPGLSREWKLGEEETGRIVRKEAFQREAAVCGRKDSEIKIALAHNQEDLAETMLHNLCRGTGLRGLCTMRPVDGEIIRPILCLSRDKIAEYLKEKKISHIQDSTNLSDEYTRNRIRHHILPMLEQQVNGKAAAHMAETAARISQAEEYLTQQSCLVLGEFQKGKEYYFTEKFFMEPQIIQVYALQQAMEQLAGRRKDLAAVHYEKVLELYEMQTGRRISLPYHMEARRDYEGVRLCRYGEEKSAGMIGEKHKGSDIQNGKTVCGKNISDREWKIRIPGTVTSPLGIFSAEIFLYEGQKIEEKKYTKWMDYDKIEKNPYIRTRRTGDYMVINAQGNTKKLNRCMIDEKIPSEYRDSIPLIACGKEIIWMVGSRMNERYKINPQTRKVLVLNYQGGNENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EUM6</accession>
    <name>A0A174EUM6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-responsive transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200867.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41027">
        <property type="protein sequence ID" value="CUO41027"/>
        <property type="gene ID" value="ERS852478_02730"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO41027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="156" mass="18435" checksum="0B0E2E7C5EF3D70C" modified="2016-09-07" version="1">MEQRYTVTQTAEILGVRASVLRYWEEELELRICRNEQGHRYYTGNDITLLANIKELKKRGLALRAIKELVPRISRTAPGTTASKVKLLEDEQPERKKILEFQKIMERLIAQELHMKKEGEDQCRDLDETIRNRQLARKEAAAALEKRSRRIRRKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EVM6</accession>
    <name>A0A174EVM6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200880.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41367">
        <property type="protein sequence ID" value="CUO41367"/>
        <property type="gene ID" value="ERS852478_02742"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025154">
        <property type="entry name" value="Put_metallopeptidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018698">
        <property type="entry name" value="VWA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09967">
        <property type="entry name" value="DUF2201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13203">
        <property type="entry name" value="DUF2201_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2201_N" evidence="2">
        <location>
            <begin position="24"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2201" evidence="1">
        <location>
            <begin position="261"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO41367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="412" mass="48260" checksum="19F4A2AF9214F849" modified="2016-09-07" version="1">MDTKKKTFHCKTTTEQELTGKKILQNCRNQLYLDFPYLDGAFTSLEYKADSSIDTIGTDGELIYFNPVFLMKKYLEDPAAVRRGYLHMLLHCLYLHIFMEPDRDSGEWDRECDCFVEQLIDKAVGEGKISLKKRKSDDTQVNTNTFDDHIFWQRTAGQASGGRRTKEKWEHILAYTSQNKTGMQSRAGTQTNDQQEELDEIYRSKYDYRKFLKQFCRLREEVELDTESFDYIFYSFGMEHYGNIPLIEPLEYKEVNRLEELVIAIDTSGSCSGKTVQRFLGETYGILSEKENFFSRMKVYIVQCDCFIQKVDVIHSEEEWKEYIRNVKIQGRGGTDFRPVFELIRQEKERKELKNLRALIYFTDGDGIYPGQKPDYETAFVFLKRTDKMKLVPPWAKCLITGTGQTAEQMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F201</accession>
    <name>A0A174F201_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable multidrug resistance ABC transporter ATP-binding/permease protein YheI</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yheI_2</name>
        <name evidence="10" type="ORF">ERS852478_02785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200918.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42958">
        <property type="protein sequence ID" value="CUO42958"/>
        <property type="gene ID" value="ERS852478_02785"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="332"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO42958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="577" mass="63891" checksum="AB0903BFDFDCB5BF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F4F9</accession>
    <name>A0A174F4F9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TRAP transporter small permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">TRAP-type C4-dicarboxylate transport system, small permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852478_02789</name>
        <name evidence="10" type="ORF">GT712_07050</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000010">
        <property type="protein sequence ID" value="MZS88833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705255.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43065">
        <property type="protein sequence ID" value="CUO43065"/>
        <property type="gene ID" value="ERS852478_02789"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007387">
        <property type="entry name" value="TRAP_DctQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35011">
        <property type="entry name" value="PTHR35011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04290">
        <property type="entry name" value="DctQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO43065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS88833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="184" mass="20732" checksum="33ED9D47ADEB30C8" modified="2016-09-07" version="1">MKIYKKIMNALAAVEKIVLVISTLLILVLTVGNVFSRKVIHRSWSFTEELVVAVFVLITLLAAALACREGELVSLTLVTDRLPKKLKKPSVILITVLSIIFSVILFKYGMDKVITQLQNGKRTFVLNWPEWIFWSFVPIGAGCMILHFIEFCLDFCCKTDSAKNTDNSTKSNMNTITTDKKEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F8Y8</accession>
    <name>A0A174F8Y8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Iron(3+)-hydroxamate import ATP-binding protein FhuC</fullName>
            <ecNumber evidence="5">3.6.3.34</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fhuC</name>
        <name evidence="5" type="ORF">ERS852478_02867</name>
        <name evidence="6" type="ORF">GT712_16390</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.34" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000043">
        <property type="protein sequence ID" value="MZS90596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379819.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45418">
        <property type="protein sequence ID" value="CUO45418"/>
        <property type="gene ID" value="ERS852478_02867"/>
    </dbReference>
    <dbReference type="GeneID" id="66494601"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO45418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS90596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="251" mass="28055" checksum="DD9415BAB1E8F856" modified="2016-09-07" version="1">MKITTEDIQVGFHARQILKGISIESKDKELVGIIGPNGSGKSTLLKCIYRILKPDAGAVYLDGEELHSMSVKSSARKMAVVAQHNYYNFDFTVREVVLMGRAPHKKALERDNAKDYRIVEEALKTVQMDAFADRTFSTLSGGEQQRVILARALAQQTPALILDEPTNHLDITHQIMLMELVKKLNVTVISAIHDLNIAAAYCDKIYVLKDGVLEGYGTPQEVLTSELIKRIYQVDSEVVNDSRGKMHILFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FA24</accession>
    <name>A0A174FA24_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamine-phosphate synthase</fullName>
            <shortName evidence="8">TP synthase</shortName>
            <shortName evidence="8">TPS</shortName>
            <ecNumber evidence="8">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="8">TMP pyrophosphorylase</shortName>
            <shortName evidence="8">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">thiE_2</name>
        <name evidence="8 13" type="synonym">thiE</name>
        <name evidence="12" type="ORF">ERS852478_02882</name>
        <name evidence="14" type="ORF">GT712_16430</name>
        <name evidence="13" type="ORF">GT728_17180</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="13 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">BIOML-A1</strain>
            <strain evidence="14 16">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8 9">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8 9">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 8 10">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000057">
        <property type="protein sequence ID" value="MZL34874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000043">
        <property type="protein sequence ID" value="MZS90604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705937.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45808">
        <property type="protein sequence ID" value="CUO45808"/>
        <property type="gene ID" value="ERS852478_02882"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="11">
        <location>
            <begin position="10"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="8">
        <location>
            <begin position="40"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO45808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL34874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS90604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="212" mass="22879" checksum="B2A6A109E447350C" modified="2016-09-07" version="1">MKFDKEKMRLYAITDRHWLNGRSLKEVVKESLDGGVTFLQLRDKNSDDETFLQEAAELQELCRDYKVPLIINDNVEIALKMNADGVHVGQSDMEAGAVREKLGPDKILGVSARTVEQALLAQERGADYLGVGAVFATGSKADAAELPHETLKAICEAVSIPVVAIGGITAENISQLKGTGICGVAVISAIYAQNNIKEAAEELKEAVDKIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FBY5</accession>
    <name>A0A174FBY5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_03422</name>
        <name evidence="2" type="ORF">ERS852478_02885</name>
        <name evidence="3" type="ORF">ERS852523_03081</name>
        <name evidence="5" type="ORF">GT712_19810</name>
        <name evidence="4" type="ORF">GT728_08685</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000039">
        <property type="protein sequence ID" value="CUP86561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000016">
        <property type="protein sequence ID" value="MZL33270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000093">
        <property type="protein sequence ID" value="MZS91210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705135.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46159">
        <property type="protein sequence ID" value="CUO46159"/>
        <property type="gene ID" value="ERS852478_02885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP86561">
        <property type="protein sequence ID" value="CUP86561"/>
        <property type="gene ID" value="ERS852523_03081"/>
    </dbReference>
    <dbReference type="GeneID" id="66494682"/>
    <dbReference type="eggNOG" id="ENOG503240C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046061">
        <property type="entry name" value="DUF6019"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19483">
        <property type="entry name" value="DUF6019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO46159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP86561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS91210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX67145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="63" mass="6999" checksum="DC13210F70D3B2B0" modified="2016-09-07" version="1">MWNELGISGGTAIVILIALYFVIKWAVKNGIKEAYSAITGKKTDEDIQNEKELKELGLDSEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FDX9</accession>
    <name>A0A174FDX9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">Int-Tn_6</name>
        <name evidence="7" type="ORF">ERS852478_02920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059741.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47026">
        <property type="protein sequence ID" value="CUO47026"/>
        <property type="gene ID" value="ERS852478_02920"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028259">
        <property type="entry name" value="AP2-like_int_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14657">
        <property type="entry name" value="Arm-DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="160"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO47026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="405" mass="47572" checksum="BCD75080E4781C9C" modified="2016-09-07" version="1">MAAYKDEERGTWYVSFYYEDWTGAKKRKVKRGFRTKKEALNFEAEYKRTAKADMDMTMGEFVEVYFRDKSQSLKDRSIKNKRDTMKAQLLPYFKDRPMNSITPAEIIQWQNTIIEKGYSDDYLKTIQNQMTALFNHAKNIYNLADNPCDKVKRMGKTSKKKMKFWTIKEYRQFMTGIEPGSKYYVLFELLFWTGAREGEALSITPADIDFERNLLHINKTYYRMHGEDVITSPKTEESNRTISIPEFLKKEIQDYISRLYELPEDERIFPMVHEAVQHKLKQVVQKTGVKKIRVHDIRHSHAAFLINKGVQPLMIKERFGHTDIRITLNTYGHLYPDQQKVVADMLDDENIKSSGSTNNRSNVTNEDKSTNVNPRQVDYSRDSSREQQITGENSWENGGIYGTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FEJ3</accession>
    <name>A0A174FEJ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pknB</name>
        <name evidence="10" type="ORF">ERS852478_02932</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
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    <dbReference type="EnsemblBacteria" id="CUO47348">
        <property type="protein sequence ID" value="CUO47348"/>
        <property type="gene ID" value="ERS852478_02932"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:protein serine kinase activity"/>
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        <property type="project" value="RHEA"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:protein phosphorylation"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="431"/>
            <end position="453"/>
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            <end position="298"/>
        </location>
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            <end position="377"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <end position="367"/>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO47348.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="635" mass="72768" checksum="2E9FFC91389EF4BD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FGG3</accession>
    <name>A0A174FGG3_9FIRM</name>
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        <recommendedName>
            <fullName evidence="7">Transporter</fullName>
        </recommendedName>
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        <name evidence="9" type="ORF">ERS852478_02969</name>
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    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
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            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="NANEUSMPORT"/>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="12"/>
            <end position="29"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO48617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FIR1</accession>
    <name>A0A174FIR1_9FIRM</name>
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        <submittedName>
            <fullName evidence="2">Acid-resistance membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_03522</name>
        <name evidence="2" type="ORF">ERS852478_03007</name>
        <name evidence="3" type="ORF">ERS852523_03211</name>
        <name evidence="4" type="ORF">GT712_01415</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZS87782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="VUX67247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000010_gene2789"/>
    <dbReference type="EnsemblBacteria" id="CUO50063">
        <property type="protein sequence ID" value="CUO50063"/>
        <property type="gene ID" value="ERS852478_03007"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP90304">
        <property type="protein sequence ID" value="CUP90304"/>
        <property type="gene ID" value="ERS852523_03211"/>
    </dbReference>
    <dbReference type="GeneID" id="66495445"/>
    <dbReference type="eggNOG" id="COG3247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF308_memb"/>
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO50063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP90304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS87782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX67247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="193" mass="21549" checksum="9498D93511CB0CBA" modified="2016-09-07" version="1">MDALKQLKLAKNGYIIMSVLFMVLGACLIIWPDCSMAVFCTAVGIMLIVYGLIKILGYFSRDIYCLAFQFDLAFGVLLAAVGIIIIVRRNVVVNLIFGIFGLLILADALFKIQMSIDAKKFGLNLWWRILLVAILTGVLGFLLLIRPFEAAEIMMILVGVSVLFEGILNLCVAIYTVKIIKNQKQDIIDMDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FUD9</accession>
    <name>A0A174FUD9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">slyD</name>
        <name evidence="7" type="ORF">ERS852478_03073</name>
        <name evidence="8" type="ORF">GT712_19530</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO52229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000079">
        <property type="protein sequence ID" value="MZS91161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380208.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000100.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52229">
        <property type="protein sequence ID" value="CUO52229"/>
        <property type="gene ID" value="ERS852478_03073"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00851">
        <property type="entry name" value="MTH1175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033913">
        <property type="entry name" value="MTH1175_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="151"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO52229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS91161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="287" mass="30314" checksum="F7556FB0A959F817" modified="2016-09-07" version="1">MKIAVTYDNGEIFQHFGKTESFKVYEVEDNKVVSSEVIGSNGTGHGALAGLLAEQGVNVLICGGIGGGAQTALTEAGIELCAGAQGNTDQAVESYLKGELVSSGANCDHHHHEEGHSCGSHEEGHSCGDSCGGGCGGCGGSQPQLTGRNVGKTCRTHYRGTFNDGTQFDSSYDRGEPLEFICGAGQMIRGFDAAVADMEVGQIIDVHLMPEEAYGMADPNAIFTMEIAQLPGSEDLTVGQQVYLSNQFGQPFPVKVTAKDEKNITFDANHEMAGKELNFKIELVEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FUT5</accession>
    <name>A0A174FUT5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C51 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_03100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201157.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53237">
        <property type="protein sequence ID" value="CUO53237"/>
        <property type="gene ID" value="ERS852478_03100"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="3">
        <location>
            <begin position="525"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO53237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="634" mass="70355" checksum="4CAA38A9F2BC2FF7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G973</accession>
    <name>A0A174G973_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF2762)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO58167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060269.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58167">
        <property type="protein sequence ID" value="CUO58167"/>
        <property type="gene ID" value="ERS852478_03252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024405">
        <property type="entry name" value="Phage_BhlA/UviB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10960">
        <property type="entry name" value="Holin_BhlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="81" mass="9504" checksum="E6FF24C704A0AA66" modified="2016-09-07" version="1">METTMLDAALSQGIWAVVAVFLLIYVVKSNEQRDKKQEERENNYQSVIEKLTEKYQILYTVQNDLNEIKNHLLAKQDSRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GA53</accession>
    <name>A0A174GA53_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">ureG</name>
        <name evidence="6" type="ORF">ERS852478_03289</name>
        <name evidence="7" type="ORF">ERS852523_04094</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
            <strain evidence="7 9">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO59354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000080">
        <property type="protein sequence ID" value="CUQ13405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_021925795.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000010_gene2767"/>
    <dbReference type="EnsemblBacteria" id="CUO59354">
        <property type="protein sequence ID" value="CUO59354"/>
        <property type="gene ID" value="ERS852478_03289"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ13405">
        <property type="protein sequence ID" value="CUQ13405"/>
        <property type="gene ID" value="ERS852523_04094"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="PTHR31715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 4" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="5">
        <location>
            <begin position="6"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO59354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUQ13405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="202" mass="22136" checksum="11ABBF640038C3C4" modified="2016-09-07" version="1">MSYVKIGVAGPVGSGKTALIEALSRKMAKDYSIGVITNDIYTKEDAQFLAKNSVLPVERIIGVETGGCPHTAIREDASMNLEAVDEMMERFPDIELLFIESGGDNLSATFSPELVDATIFVIDVAEGDKIPRKGGPGITRSDLLVINKIDLAPYVGASLEVMERDSRKMRGDRPFQFTNIRGDENVDKVVEWIKKNVLLEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GA82</accession>
    <name>A0A174GA82_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_03402</name>
        <name evidence="5" type="ORF">BWLFYP14_03425</name>
        <name evidence="2" type="ORF">ERS852478_02913</name>
        <name evidence="3" type="ORF">ERS852478_03257</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO58517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46860">
        <property type="protein sequence ID" value="CUO46860"/>
        <property type="gene ID" value="ERS852478_02913"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58517">
        <property type="protein sequence ID" value="CUO58517"/>
        <property type="gene ID" value="ERS852478_03257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO46860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO58517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX67125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX67148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="32" mass="3498" checksum="E7A0C70DC193DC84" modified="2016-09-07" version="1">MSIVDFIAVVSFGLTCFGLGYTFGKDNNKPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GCN8</accession>
    <name>A0A174GCN8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">purF_2</name>
        <name evidence="5" type="synonym">purF</name>
        <name evidence="14" type="synonym">purF_1</name>
        <name evidence="14" type="ORF">BWLFYP14_00753</name>
        <name evidence="11" type="ORF">ERS852478_03313</name>
        <name evidence="13" type="ORF">GT712_14910</name>
        <name evidence="12" type="ORF">GT728_14650</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">BIOML-A1</strain>
            <strain evidence="13 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000039">
        <property type="protein sequence ID" value="MZL34403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000034">
        <property type="protein sequence ID" value="MZS90323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000019">
        <property type="protein sequence ID" value="VUX63004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381205.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60274">
        <property type="protein sequence ID" value="CUO60274"/>
        <property type="gene ID" value="ERS852478_03313"/>
    </dbReference>
    <dbReference type="GeneID" id="66494394"/>
    <dbReference type="eggNOG" id="COG0034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="8"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO60274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL34403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS90323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX63004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="473" mass="51384" checksum="325414D2BCA97E2B" modified="2016-09-07" version="1">MAGIKEECGVFGIYDLDGGNVVPSIYYGLTSLQHRGQESCGLAVSDTKGERGNVKFHKDLGLVSEVLRQDVVRKYEGDIGIGHVRYSTTGASVAENAQPLVLSYVKGTLALAHNGNLVNTPELKWELIQNGAIFHTTTDSEVIAFHIARERVHSKTVEEAVLKTAKKIKGAYGLVVMSPRKLIAVRDPYGLKPLCLGKRGNAYVIASESCALTSVSAEFIRDIEPGEILTITKDGLKSNKELASAAAKRAHCVFEYIYFARLDSTIDGVKVYDARIRGGKSLAKSYPVEADLVTGVPESGLPAAKGYSEASGIPFAFAFYKNSYIGRTFIKPTQEERESSVHLKLSVLESVVKDKRIVLVDDSIVRGTTIANLIHMLKEAGAKEVHVRISSPPFLHPCYFGTDVPSNDQLIAASHSTEEICKMIGADSLGYMQTDYLEGMAGGLPLCKACFDGNYPMEIPDYTNAEFADIVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GKF0</accession>
    <name>A0A174GKF0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutaconyl-CoA decarboxylase subunit beta</fullName>
            <ecNumber evidence="9">4.1.1.70</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Sodium ion-translocating decarboxylase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gcdB</name>
        <name evidence="12" type="ORF">BWLFYP14_02977</name>
        <name evidence="9" type="ORF">ERS852478_03393</name>
        <name evidence="10" type="ORF">ERS852523_02821</name>
        <name evidence="11" type="ORF">GT728_07660</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">2789STDY5834863</strain>
            <strain evidence="10 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 16">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.1.1.70" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000033">
        <property type="protein sequence ID" value="CUP79155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000014">
        <property type="protein sequence ID" value="MZL33081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000072">
        <property type="protein sequence ID" value="VUX66701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704466.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000019_gene166"/>
    <dbReference type="EnsemblBacteria" id="CUO63014">
        <property type="protein sequence ID" value="CUO63014"/>
        <property type="gene ID" value="ERS852478_03393"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP79155">
        <property type="protein sequence ID" value="CUP79155"/>
        <property type="gene ID" value="ERS852523_02821"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1883">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018801">
        <property type="term" value="F:glutaconyl-CoA decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005661">
        <property type="entry name" value="OadB_MmdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35806">
        <property type="entry name" value="PTHR35806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03977">
        <property type="entry name" value="OAD_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015658">
        <property type="entry name" value="MmdB_OadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01109">
        <property type="entry name" value="Na_pump_decarbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR015658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO63014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP79155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL33081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX66701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="382" mass="40257" checksum="7919BB8EB5B0230B" modified="2016-09-07" version="1">MSYVTETLSNLIHQTAFFNLTWGNYLMIAVACVFLYLAIKKGFEPLLLVPIAFGMLLVNIYPDIMANPEDMSNGVGGLLHYFYILDEWSILPSLIFMGVGAMTDFGPLIANPISFLMGAAAQLGIYAAYFLAIFLGFNGKAAAAISIIGGADGPTSIFLAGKLGQSALMGPIAVAAYSYMSLVPIIQPPIMKLCTTEKERKIKMDQLRPVSKLEKILFPIVITIVVCLILPTTAPLVGMLMLGNLFRECGVVKQLTETASNALMYIVVILLGTSVGASTSAEAFLNADTLKIVVLGLVAFAIGTFGGCMLGKLLCKLTHGKINPLIGSAGVSAVPMAARVSQKVGAEADPTNFLLMHAMGPNVAGVIGTAVAAGTFMAIFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GMB1</accession>
    <name>A0A174GMB1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BMC domain protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">BMC domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Carboxysome structural protein EutM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_01440</name>
        <name evidence="3" type="ORF">ERS852478_03366</name>
        <name evidence="5" type="ORF">GT712_18810</name>
        <name evidence="4" type="ORF">GT728_19030</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">BIOML-A1</strain>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO62040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000079">
        <property type="protein sequence ID" value="MZL35209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000064">
        <property type="protein sequence ID" value="MZS91032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000033">
        <property type="protein sequence ID" value="VUX64586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703970.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000079.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62040">
        <property type="protein sequence ID" value="CUO62040"/>
        <property type="gene ID" value="ERS852478_03366"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032VEP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="9"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO62040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL35209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS91032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX64586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="99" mass="10309" checksum="C560036EF0AB0D52" modified="2016-09-07" version="1">MAKNYDGMAVGAFELDNLVACFVALDAASKAANVTIQSVERNRLKSGACVKIRGSVSDVNAAMEVALETAKPLGKIVSHTVIASPSADTEVALKMTINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GPZ8</accession>
    <name>A0A174GPZ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Segregation and condensation protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">scpA</name>
        <name evidence="3" type="ORF">ERS852478_03404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Associated with two foci at the outer edges of the nucleoid region in young cells, and at four foci within both cell halves in older cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ScpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201379.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63337">
        <property type="protein sequence ID" value="CUO63337"/>
        <property type="gene ID" value="ERS852478_03404"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01805">
        <property type="entry name" value="ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO63337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="270" mass="31590" checksum="5D9793D5F0BC43F3" modified="2016-09-07" version="1">MGIPVKLEVFEGPLDLLLHLIEKNKIDIYDIPIVEITDQYMEYIHAMEREDLGIMSEFMVMAATLLDIKCKMLLPKEVNEEGEEEDPRAELVEKLLEYKMYKFMSYELKDKMDDAANVFFKEPTLPDEVLQYREPVDPKELLAGLTLEKLNAIYKSIIRRQEDKVDPIRSKFGTIEKEEISLSDKMIEIKDFARTHRKFSFRNLLESQCSKVQVIVTFLSILELMKMGHIHVEQDGLFDDISVEVQTDPDTWKNLTEFAEDEPQNTEINM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GRP2</accession>
    <name>A0A174GRP2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">sporulation initiation inhibitor protein Soj</fullName>
            <ecNumber evidence="3">3.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">soj_6</name>
        <name evidence="3" type="synonym">soj_3</name>
        <name evidence="3" type="ORF">BWLFYP14_02339</name>
        <name evidence="2" type="ORF">ERS852478_03470</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65372">
        <property type="protein sequence ID" value="CUO65372"/>
        <property type="gene ID" value="ERS852478_03470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="2"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO65372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="214" mass="23499" checksum="3DE74D38BE0641F5" modified="2016-09-07" version="1">MAKVISIVNQKGGTGKSACTANLAVGLAQKNMKVLIVDADPQSDVSAGFGYRDCDESNETLTALMDTVMKDEDIPSDCYIRHQAEGIDIICSNIGLAGTEVQLVNAMSREYVLKQILYGIKDQYDAIIIDCMPSLGMITINALAASDEVLIPVEASYLPIKGLQQLEKLDRTVDEIRRRFGYFSIQRAAMYQNKVLSHLDAGTHTVHPHSYFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GU60</accession>
    <name>A0A174GU60_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bacteriohemerythrin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">McHr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BWLFYP14_02345</name>
        <name evidence="5" type="ORF">ERS852478_03475</name>
        <name evidence="7" type="ORF">GT712_16550</name>
        <name evidence="6" type="ORF">GT728_16075</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">BIOML-A1</strain>
            <strain evidence="7 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hemerythrin family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708195.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65511">
        <property type="protein sequence ID" value="CUO65511"/>
        <property type="gene ID" value="ERS852478_03475"/>
    </dbReference>
    <dbReference type="GeneID" id="66493931"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12107">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035938">
        <property type="entry name" value="Hemerythrin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012827">
        <property type="entry name" value="Hemerythrin_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47188">
        <property type="entry name" value="SSF47188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02481">
        <property type="entry name" value="hemeryth_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="4">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO65511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL34669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS90625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX65975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="144" mass="17423" checksum="0CA923C141AA38A4" modified="2016-09-07" version="1">MTYDLNITFDDNLVTGNETIDTQHKELIDRIQNFVTACQNGDSKVKAIKMLDYLDEYTDFHFKEEEKLQEKSGYPEREKHYEKHEEFRKTIQELYEYLQEYEGPTDRFSELVQKNVIDWLFGHIKTYDRSVAKFIFMKQNPDRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H2N2</accession>
    <name>A0A174H2N2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201445.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68491">
        <property type="protein sequence ID" value="CUO68491"/>
        <property type="gene ID" value="ERS852478_03575"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009492">
        <property type="entry name" value="TniQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06527">
        <property type="entry name" value="TniQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO68491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="469" mass="55646" checksum="B755DE5FCFF1727F" modified="2016-09-07" version="1">MIAFLPELYSDELVYSWLSRYYVKSGCLSFAYVVEDLYVHQYTRPDTEFLNEMKPDVMELIDRYCNIEQLVQRHTMFSSYGRFLPLERKQEAYEALLRMHGNFNNLLSIPKNQRGTGRFLRYCPICAREDREQHGETYWHRIHQIEGIQICRRHGCYLCESNVSMDRQKKAGFWDAETLIPQSETIQICRDRRKIAFTEYISQVFEAAMDFQGKISVADFLKLRLARYARTDSGASLSLDNLYMDYQEFFGEDACMTKGQMQKILLGVRYHFSDICKLAMFAGISVEELTAIPDTVKDSLREPVYQQVAEELQVDYDLVCKIGEAVLKRYERKERVVQRRKRTFAWERMDAEMLPNVKKTVKRLYQTGEERPRRITVFLVQKEMGFPDKRFDKLPKCKAEILKYQETQKEYWARQAVWAYRKLLREGQPVNWTKIRRLTNMRNVDFQGCKAFLDNYGTSEEVKHLQGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HF13</accession>
    <name>A0A174HF13_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">macB_11</name>
        <name evidence="5" type="ORF">ERS852478_03685</name>
        <name evidence="7" type="ORF">GT712_11885</name>
        <name evidence="6" type="ORF">GT728_20110</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">BIOML-A1</strain>
            <strain evidence="7 9">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO71956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000096">
        <property type="protein sequence ID" value="MZL35416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003061398.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000096.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71956">
        <property type="protein sequence ID" value="CUO71956"/>
        <property type="gene ID" value="ERS852478_03685"/>
    </dbReference>
    <dbReference type="GeneID" id="60884208"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO71956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL35416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS89753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="256" mass="28456" checksum="D515347F9DDE3519" modified="2016-09-07" version="1">MEHILNLEQVKKYYGGNSGNITKAVDGISMYVDKGEFVAIMGASGSGKTTLLNCISTIDTVTSGHITVNNQDITKIKDKDFADFRRENLGFIFQDFNLLDTLTIGENISLSLVINKQNPTDIEKRVHAIADKLGIRDILSKFPYEVSGGQKQRCACARALINEPKLILADEPTGALDSKASRLLLETMSEINKKMQATILMVTHDPFSASFCERILFLKDGKIFNEIFRGEKSRKDFFNEILDILTLLGGEVGNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HFE4</accession>
    <name>A0A174HFE4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type transport system involved in multi-copper enzyme maturation, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO72086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201495.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72086">
        <property type="protein sequence ID" value="CUO72086"/>
        <property type="gene ID" value="ERS852478_03693"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="256" mass="28964" checksum="651FFCB79EB78E8D" modified="2016-09-07" version="1">MKSFIAFFKKEIFECIRSGELTFFCILFLIFGIMNPAIAKLTPWMLETLSDSLAEQGMMVTEVTVNALTSWTQFFKNIPIALIVFVFLYSGIFTKEYETNTLILILTKGLSRYKVVFAKFFVMFTMWTIGYLLCFAVTYGYNAFFWDNSIAVGLLPAMVHWWLFGVWIIGLIVLFSVLVKSYTGVLLGTGGSVLGVYLISFFPKAWKYTPTTLMESASLLIGTKSIEDYGIAVLITILLVVICLIVSITVMNRKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HJT3</accession>
    <name>A0A174HJT3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bacitracin export ATP-binding protein BceA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">macB_14</name>
        <name evidence="6" type="synonym">bceA</name>
        <name evidence="6" type="ORF">BWLFYP14_02742</name>
        <name evidence="5" type="ORF">ERS852478_03799</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000050">
        <property type="protein sequence ID" value="CUO75192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703350.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000128.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75192">
        <property type="protein sequence ID" value="CUO75192"/>
        <property type="gene ID" value="ERS852478_03799"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO75192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="232" mass="25922" checksum="33D6423628C12CA4" modified="2016-09-07" version="1">MFLQIQGIQKSFGAGDSRVDVLKGLDLDIERGEFCVLLGPSGSGKSTLLNIIGGIDSADEGNLVIDGERLADMSEKNLSLYRRKHLGYIFQMYNLIPNLTVRENIEVGAYLSDKPLDVDELLHTLGIYEHQRKLPNQLSGGQQQRTAIGRAIVKNPDILLCDEPTGALDYNTSKEILKLIETVNQKYGNTIVMVTHNDAIKDMADRVVKLRDGMIRKNYLNEHKIPAAELDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HQ23</accession>
    <name>A0A174HQ23_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kynurenine formamidase</fullName>
            <ecNumber evidence="1">3.5.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kynB</name>
        <name evidence="1" type="ORF">ERS852478_03810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000052">
        <property type="protein sequence ID" value="CUO75626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201535.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000052.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75626">
        <property type="protein sequence ID" value="CUO75626"/>
        <property type="gene ID" value="ERS852478_03810"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO75626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="230" mass="26200" checksum="4D81F9F0C9C79EF5" modified="2016-09-07" version="1">MLIELSYIISLDMPKWPTNPAERIEYNTVIQNGDPSNASSVFHHLHTGTHVDAPFHFDANGKTIDQIPIEDFHYTKPLVLEIAKGKGERIRYEDLKLHESEIKECDILFLYTGHSRLRDISPEDFVDNFPCMEVMAAKYLRKEFPELKAIAMDSISYDSAITGGDEGFPCHHALLETNSEQKERTLLLFEDVNIQKLLGVERIKEICAFPIRFSQLEAAPVAMVAITDHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JBC7</accession>
    <name>A0A174JBC7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">frr</name>
        <name evidence="10" type="ORF">BWLFYP14_02379</name>
        <name evidence="6" type="ORF">ERS852478_02065</name>
        <name evidence="7" type="ORF">ERS852523_00023</name>
        <name evidence="9" type="ORF">GT712_14130</name>
        <name evidence="8" type="ORF">GT728_13830</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO94918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000035">
        <property type="protein sequence ID" value="MZL34253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000030">
        <property type="protein sequence ID" value="MZS90176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX66009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707656.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000073_gene2015"/>
    <dbReference type="EnsemblBacteria" id="CUO17821">
        <property type="protein sequence ID" value="CUO17821"/>
        <property type="gene ID" value="ERS852478_02065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94918">
        <property type="protein sequence ID" value="CUO94918"/>
        <property type="gene ID" value="ERS852523_00023"/>
    </dbReference>
    <dbReference type="GeneID" id="66493739"/>
    <dbReference type="eggNOG" id="COG0233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="5">
        <location>
            <begin position="19"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO17821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO94918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL34253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS90176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX66009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="183" mass="20717" checksum="34BC1C0D4879F4C7" modified="2016-09-07" version="1">MDERIQKYEEKMKKTLASLESELVTIRAGRANPHILDKLAVDYYGAPTPLQQVANITVPEARMIQIQPWESSLIKGIEKAILTSDLGLNPSNDGKVIRLVFPELTEERRKELVKDVKKKGEAAKVAVRNIRRDANDAFKKLAKQDVSEDEIKELEEKIQKSTDKYIKEVDAAVDAKSKEIMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KSE6</accession>
    <name>A0A174KSE6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">infC</name>
        <name evidence="12" type="ORF">BWLFYP14_01809</name>
        <name evidence="8" type="ORF">ERS852478_00699</name>
        <name evidence="9" type="ORF">ERS852523_00645</name>
        <name evidence="11" type="ORF">GT712_03195</name>
        <name evidence="10" type="ORF">GT728_03730</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP12957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706524.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000015_gene3701"/>
    <dbReference type="EnsemblBacteria" id="CUN64992">
        <property type="protein sequence ID" value="CUN64992"/>
        <property type="gene ID" value="ERS852478_00699"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12957">
        <property type="protein sequence ID" value="CUP12957"/>
        <property type="gene ID" value="ERS852523_00645"/>
    </dbReference>
    <dbReference type="GeneID" id="66493476"/>
    <dbReference type="eggNOG" id="COG0290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="78"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN64992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP12957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL32326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS88118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX65044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="164" mass="18636" checksum="4F6B2C44712D9FD0" modified="2016-09-07" version="1">MINEQIRDKEVRLIGSDGEQLGIMSAKEAMFKAQEAGLDLVKIAPQAKPPVCKIIDYGKYRYELARKEKEAKKKQKTIDVKEVRLSPNIDTNDLNTKVNAARKFLSKGDRVKVTLRFRGREMAHMASSRHVLDDFAKQLADVATVEKAPKVEGRSMTMFLTEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KTH0</accession>
    <name>A0A174KTH0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">engD</name>
        <name evidence="4 9" type="synonym">ychF</name>
        <name evidence="11" type="ORF">BWLFYP14_01795</name>
        <name evidence="7" type="ORF">ERS852478_00713</name>
        <name evidence="8" type="ORF">ERS852523_00631</name>
        <name evidence="10" type="ORF">GT712_03125</name>
        <name evidence="9" type="ORF">GT728_03800</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP12560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706507.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000016_gene3658"/>
    <dbReference type="EnsemblBacteria" id="CUN65417">
        <property type="protein sequence ID" value="CUN65417"/>
        <property type="gene ID" value="ERS852478_00713"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12560">
        <property type="protein sequence ID" value="CUP12560"/>
        <property type="gene ID" value="ERS852523_00631"/>
    </dbReference>
    <dbReference type="GeneID" id="66493490"/>
    <dbReference type="eggNOG" id="COG0012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="280"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN65417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP12560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL32340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS88104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX65016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="365" mass="40506" checksum="D5EE38E73C0755BE" modified="2016-09-07" version="1">MKLGIVGLPNVGKSTLFNSLTKAGAESANYPFCTIDPNVGVVTVPDERLKLLGDFYHSKKVTPAVIEFVDIAGLVKGASKGEGLGNQFLANIREVDAIVHVVRCFEDSNVIHVDGSIDPIRDIETINLELIFSDLEILERRIAKVTKTARMDKEAAKELDFLQKVKTHLEDGKMAITMEMENEDEEAWMSTYNLLTWKPVIYAANVAEGDLADDGESNSHVQAVRKYAAEQNSEIFVICAEIEEEISELDDDEKKMFLEDLGLTESGLEKLVKASYHLLGLMSFLTSGEDETRAWTIKIGTKAPQAAGKIHTDFERGFIKAEVVNYQDLLDCGSYAGAREKGLVRMEGKEYVVQDGDVILFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KZ64</accession>
    <name>A0A174KZ64_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S-containing hydro-lyase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Fumarate hydratase class I, anaerobic</fullName>
            <ecNumber evidence="5">4.2.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fumB</name>
        <name evidence="8" type="ORF">BWLFYP14_02547</name>
        <name evidence="4" type="ORF">ERS852478_00046</name>
        <name evidence="5" type="ORF">ERS852523_00721</name>
        <name evidence="7" type="ORF">GT712_07675</name>
        <name evidence="6" type="ORF">GT728_12855</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">2789STDY5834863</strain>
            <strain evidence="5 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 13">BIOML-A1</strain>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP15696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000031">
        <property type="protein sequence ID" value="MZL34067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380686.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1410"/>
    <dbReference type="EnsemblBacteria" id="CUN42044">
        <property type="protein sequence ID" value="CUN42044"/>
        <property type="gene ID" value="ERS852478_00046"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15696">
        <property type="protein sequence ID" value="CUP15696"/>
        <property type="gene ID" value="ERS852523_00721"/>
    </dbReference>
    <dbReference type="GeneID" id="66492886"/>
    <dbReference type="eggNOG" id="COG1838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase_C" evidence="3">
        <location>
            <begin position="6"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN42044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP15696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL34067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS88950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="188" mass="20169" checksum="BF9CD0519BFE49E2" modified="2016-09-07" version="1">MERKKITLPLTRELARTLHAGDQVLLTGTIYTSRDAGHKRMCEALAKGEKIPFDPTDATIYYVGPTPAKPGAVIGSAGPTTSGRMDAYAPTMMSVGARGMIGKGARLPEVVDAMKKYDGVYFGAIGGAGALLAKCIKKAELIAYEDLGAEALRKLYVEDMPLVVIIDSEGNNLYEMGKAEYLKEHGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LJY1</accession>
    <name>A0A174LJY1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted integral membrane protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">VanZ family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">VanZ like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_02307</name>
        <name evidence="3" type="ORF">ERS852478_01340</name>
        <name evidence="4" type="ORF">ERS852523_00932</name>
        <name evidence="5" type="ORF">GT712_19055</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
            <strain evidence="4 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000007">
        <property type="protein sequence ID" value="CUP21990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000068">
        <property type="protein sequence ID" value="MZS91077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000043">
        <property type="protein sequence ID" value="VUX65942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025581246.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000101.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000156_gene545"/>
    <dbReference type="EnsemblBacteria" id="CUN89823">
        <property type="protein sequence ID" value="CUN89823"/>
        <property type="gene ID" value="ERS852478_01340"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21990">
        <property type="protein sequence ID" value="CUP21990"/>
        <property type="gene ID" value="ERS852523_00932"/>
    </dbReference>
    <dbReference type="GeneID" id="66494903"/>
    <dbReference type="eggNOG" id="COG5652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016747">
        <property type="entry name" value="Phosphotransbutyrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019083">
        <property type="entry name" value="UCP019083_VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN89823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP21990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS91077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="169" mass="18919" checksum="FD21796087B5F3F4" modified="2016-09-07" version="1">MKILITLLKPLSFLPALLMMYIIFSFSAQPGEVSGNLSYKISYEIIETKSELLSENLSSEEIAYKADGIHYYVRKAAHMTEYFLLAIAISFPLYVYGVRGIWLMLLAGIVCVGFAGLDEYHQSFVDARTPAVKDVGIDSIGAFIGILLVQAFCWSVLNNPNKKKKKRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M5C2</accession>
    <name>A0A174M5C2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PucR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Purine catabolism regulatory protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Sugar diacid regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cdaR_1</name>
        <name evidence="4" type="synonym">cdaR_2</name>
        <name evidence="8" type="synonym">pucR_1</name>
        <name evidence="8" type="ORF">BWLFYP14_00319</name>
        <name evidence="4" type="ORF">ERS852478_03218</name>
        <name evidence="5" type="ORF">ERS852523_01223</name>
        <name evidence="7" type="ORF">GT712_16760</name>
        <name evidence="6" type="ORF">GT728_05035</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">2789STDY5834863</strain>
            <strain evidence="5 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 13">BIOML-A1</strain>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP31573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000045">
        <property type="protein sequence ID" value="MZS90664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707357.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000049_gene1304"/>
    <dbReference type="EnsemblBacteria" id="CUO57328">
        <property type="protein sequence ID" value="CUO57328"/>
        <property type="gene ID" value="ERS852478_03218"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP31573">
        <property type="protein sequence ID" value="CUP31573"/>
        <property type="gene ID" value="ERS852523_01223"/>
    </dbReference>
    <dbReference type="GeneID" id="66496191"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="126"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="294"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO57328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP31573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL32583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS90664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX67474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="362" mass="41433" checksum="9AA288D0CF59222A" modified="2016-09-07" version="1">MISNQVLQNTLEGLKEISRTEFCVLDTEGKVLASTFADFSIATQDVQAFVESQADSQLVKGFQYFKVCDDYQLEYILVAHGDDEDTYMVGKLAAFQIQNLIVAYKERFDKDSFIKNLLLDNLLLVDIYNRAKKLHIEADVRRVVMILEMPQEKDHSSMESVKSLFGGKSKDFITAVDEKSIIVVKELEDGENYPEMDQLAHTILDTLGMGNDGKTHMAYGTIVNELKEVSRSYKEARMALDVGKIFFGDKEVIAYSSLGIGRLIYQLPIPLCKMFIKEIFGGKSPDDFDEETLVTIDKFFENSLNVSETSRQLYIHRNTLVYRLDKLQKSTGLDLRVFEDAITFKIALMVVRYMKYMETLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MA83</accession>
    <name>A0A174MA83_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpsN1</name>
        <name evidence="7" type="synonym">rpsN</name>
        <name evidence="7" type="synonym">rpsZ</name>
        <name evidence="12" type="ORF">BWLFYP14_00268</name>
        <name evidence="8" type="ORF">ERS852478_01670</name>
        <name evidence="9" type="ORF">ERS852523_01282</name>
        <name evidence="11" type="ORF">GT712_08925</name>
        <name evidence="10" type="ORF">GT728_04755</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707268.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2971"/>
    <dbReference type="EnsemblBacteria" id="CUO03020">
        <property type="protein sequence ID" value="CUO03020"/>
        <property type="gene ID" value="ERS852478_01670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33263">
        <property type="protein sequence ID" value="CUP33263"/>
        <property type="gene ID" value="ERS852523_01282"/>
    </dbReference>
    <dbReference type="GeneID" id="66496133"/>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO03020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP33263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL32529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS89190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX67427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="61" mass="7194" checksum="3CDD19B7DE8F4575" modified="2016-09-07" version="1">MAKTAMKIKQQRKQKFSTREYTRCNICGRPHSVLRKYGICRICFRELAYKGQIPGVKKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174P655</accession>
    <name>A0A174P655_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Preprotein translocase subunit YajC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yajC</name>
        <name evidence="13" type="ORF">BWLFYP14_02241</name>
        <name evidence="9" type="ORF">ERS852478_03203</name>
        <name evidence="10" type="ORF">ERS852523_01942</name>
        <name evidence="12" type="ORF">GT712_14585</name>
        <name evidence="11" type="ORF">GT728_18230</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000018">
        <property type="protein sequence ID" value="CUP53785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000068">
        <property type="protein sequence ID" value="MZL35062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000032">
        <property type="protein sequence ID" value="MZS90263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703490.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000004_gene1930"/>
    <dbReference type="EnsemblBacteria" id="CUO56685">
        <property type="protein sequence ID" value="CUO56685"/>
        <property type="gene ID" value="ERS852478_03203"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP53785">
        <property type="protein sequence ID" value="CUP53785"/>
        <property type="gene ID" value="ERS852523_01942"/>
    </dbReference>
    <dbReference type="GeneID" id="66493904"/>
    <dbReference type="eggNOG" id="COG1862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO56685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP53785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL35062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS90263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX65875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="99" mass="10938" checksum="3427A0A8D15F25A6" modified="2016-09-07" version="1">MNASSGMGMVGAIVWMVVLFGIMYFLMLRPQKKEQKRLQAMLNDMEVGDSIVTTGGFYGVVIDMTEEDVIVEFGNNKNCRIPMRKQAIAEVEKAGSAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174RR95</accession>
    <name>A0A174RR95_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00569</name>
        <name evidence="3" type="ORF">ERS852523_03049</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000038">
        <property type="protein sequence ID" value="CUP85655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055152683.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000024_gene312"/>
    <dbReference type="EnsemblBacteria" id="CUN59564">
        <property type="protein sequence ID" value="CUN59564"/>
        <property type="gene ID" value="ERS852478_00569"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP85655">
        <property type="protein sequence ID" value="CUP85655"/>
        <property type="gene ID" value="ERS852523_03049"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006750">
        <property type="entry name" value="YdcZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34821">
        <property type="entry name" value="PTHR34821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04657">
        <property type="entry name" value="DMT_YdcZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN59564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP85655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="144" mass="15698" checksum="A84A0EAF363546C5" modified="2016-09-07" version="1">MWGFIVALISGALMSIQGVFNTEVTKQTSLWVSTGWVQLSAFAVCVLAWLFTGRESVAALWQVDNKYTLLGGVIGAFITITVIQSMGALGPARAAMLIVISQLAVAYVIELFGLFGVDKEPFEWRKILGLLIAISGIVIFKWQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174TTE8</accession>
    <name>A0A174TTE8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">arlR_2</name>
        <name evidence="11" type="ORF">ERS852478_03294</name>
        <name evidence="12" type="ORF">ERS852523_04099</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">2789STDY5834863</strain>
            <strain evidence="12 14">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO59508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000080">
        <property type="protein sequence ID" value="CUQ13504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055153868.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000010_gene2772"/>
    <dbReference type="EnsemblBacteria" id="CUO59508">
        <property type="protein sequence ID" value="CUO59508"/>
        <property type="gene ID" value="ERS852478_03294"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ13504">
        <property type="protein sequence ID" value="CUQ13504"/>
        <property type="gene ID" value="ERS852523_04099"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO59508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUQ13504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="225" mass="25346" checksum="169B206C79998E20" modified="2016-09-07" version="1">MEQLLIIEDDIGLNQGLSKALKADDRQIISCHDLKAAREQLLCGSVSLILLDINLPDGSGLELLREVKENMPGVPVILLTANDTDLDIVDGLERGADDYITKPFSLSVLRARVNTQLRKQASNHKNVSIHIDLFHFDFEAMTFYVGDSKVELSKTEQKLLRLLVENRGRTMTRGDLVDRIWTDGAEYVDENALSVTIKRLRDKLGAQKYIKTVYGIGYSWVTKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WUL9</accession>
    <name>A0A173WUL9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-aminohexanoate-dimer hydrolase</fullName>
            <ecNumber evidence="2">3.5.1.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nylB</name>
        <name evidence="2" type="ORF">ERS852478_00083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.46" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199495.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43212">
        <property type="protein sequence ID" value="CUN43212"/>
        <property type="gene ID" value="ERS852478_00083"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019875">
        <property type="term" value="F:6-aminohexanoate-dimer hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN43212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="619" mass="69973" checksum="65E917850F62BB4B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WWE4</accession>
    <name>A0A173WWE4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00084</name>
        <name evidence="3" type="ORF">ERS852523_04537</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000158">
        <property type="protein sequence ID" value="CUQ26156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580237.1">
        <property type="nucleotide sequence ID" value="NZ_JAAILR010000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000068_gene3406"/>
    <dbReference type="EnsemblBacteria" id="CUN43246">
        <property type="protein sequence ID" value="CUN43246"/>
        <property type="gene ID" value="ERS852478_00084"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ26156">
        <property type="protein sequence ID" value="CUQ26156"/>
        <property type="gene ID" value="ERS852523_04537"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN43246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ26156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="136" mass="16110" checksum="AE9CA765FE6301C0" modified="2016-09-07" version="1">MKENLIHYRTCVCNINYHMVWSVKYRRKILNAEVEAYLQELVQEIAEDKGFTIHLFECGEGDHVHCFVSAPPKLSITAIVKYLKGISGRKLFERFPEIRNQLWKGELWNHSYYVETVGSVSEENIRRYIEHQSKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WY15</accession>
    <name>A0A173WY15_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
            <shortName evidence="8">DHQS</shortName>
            <ecNumber evidence="8">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">aroB</name>
        <name evidence="10" type="ORF">ERS852478_00110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059753.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43980">
        <property type="protein sequence ID" value="CUN43980"/>
        <property type="gene ID" value="ERS852478_00110"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="9">
        <location>
            <begin position="71"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="109"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN43980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="363" mass="40527" checksum="75EEBD1DAD1383D4" modified="2016-09-07" version="1">MAEQKLLVKREGDFHYPIYFKNDFQDLAGAIREEGLENRKICIVTDSHVAPLYYEAVKSALQEISSEIFSFVFEAGEKNKNLNTVQELYKTLIENEMDRKGLLVALGGGVVGDLTGFGASTYLRGIDFIQVPTTLLAQVDSSVGGKTGVDFLQYKNMVGAFHQPRLVYMNMSTLQSLPNREFTCGMGEILKTGLICDEEFFRFVCKNQSEISKLDLSMLSRMIRRCCEIKAGVVERDPKEQGERALLNLGHTVGHAVEKMKNFQLLHGQCVGVGLIAAAYLSMQRGLLTEEEYEEIRKGCHSYNLPLSVDSLNAGDVLAATKKDKKMEAGHIKFILMDGIGKSFIDKTVTDEELLQAIREILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X0Y4</accession>
    <name>A0A173X0Y4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45274">
        <property type="protein sequence ID" value="CUN45274"/>
        <property type="gene ID" value="ERS852478_00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012332">
        <property type="entry name" value="Autotransporter_pectin_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015088" evidence="3">
        <location>
            <begin position="27"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN45274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="685" mass="71077" checksum="10D1BF0FA28BDDFA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X3V7</accession>
    <name>A0A173X3V7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ECF RNA polymerase sigma factor SigE</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor sigM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sigM_1</name>
        <name evidence="5" type="synonym">sigE_2</name>
        <name evidence="5" type="ORF">BWLFYP14_02651</name>
        <name evidence="4" type="ORF">ERS852478_00153</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45078">
        <property type="protein sequence ID" value="CUN45078"/>
        <property type="gene ID" value="ERS852478_00153"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="116"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN45078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="182" mass="21460" checksum="F9508C72381EFD64" modified="2016-09-07" version="1">MATDEELYGQYLSGDETGLELLIKKYGDPLTLYIDGYLHDVHEAEDLMMETFSWLFTKKPRIRDGCFKAYLYKAARHMALRHKSRRRIIFSLDDLTREPEAQTLVEEIVRTKERNQILHLCMDELNSDYREALYLTYFEGMSYQQAAKVMGKSVKQITNMVYRGKERLRGLLQREGITDVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XEA4</accession>
    <name>A0A173XEA4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-aminopeptidase/D-esterase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Peptidase S58 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00289</name>
        <name evidence="4" type="ORF">GT712_05775</name>
        <name evidence="3" type="ORF">GT728_20340</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000100">
        <property type="protein sequence ID" value="MZL35453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000009">
        <property type="protein sequence ID" value="MZS88608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381361.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000100.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49994">
        <property type="protein sequence ID" value="CUN49994"/>
        <property type="gene ID" value="ERS852478_00289"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN49994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL35453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="321" mass="33475" checksum="5CA421CA8752728D" modified="2016-09-07" version="1">MSLLKEISITELSNLRIGHTSDHDAKTGVTVLYFPNGAKAGCDISGGGPASRETPLTSPVTADNPINAIVLSGGSAYGLAAADGVMNYLESQNIGYNTGAALVPLVCQSCIYDLSYGDPKIRPTAKMGEEACRQAFAGTDTRTGNIGAGTGATVGKLYGMKQSMKSGLGIAAVSVKNFQMAAIVVVNALGDIFSPQNGQKIAGLKTPDRSGFLDSVHELYRFMTPHDQFTGNTTIGAVITNGAFSKAELNKIASMTRCAYARCINPVATMADGDSIYAASIGNVSVDINMAGTLAAEVMAQAIQNAIHTSRIPDEEFLKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XLG5</accession>
    <name>A0A173XLG5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yvdD</name>
        <name evidence="4" type="ORF">BWLFYP14_01967</name>
        <name evidence="2" type="ORF">ERS852478_00347</name>
        <name evidence="3" type="ORF">GT728_06585</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000011">
        <property type="protein sequence ID" value="MZL32876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199581.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51786">
        <property type="protein sequence ID" value="CUN51786"/>
        <property type="gene ID" value="ERS852478_00347"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN51786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="180" mass="19517" checksum="5D4DC15D2B916969" modified="2016-09-07" version="1">MNITVYLGALEGNDPALGNAVRELGTWIGESGNSLVYGGSKSGLMGQIAESVLNAGGKVTGVEPQFFIDSELQYDEITKLIVTKDMAERKAKMIELGDAFIAFPGGTGTLEEITEVMSMVSLKHLDAPCILYNLNGYYDSLKQLLDHMIKMGLSSENRQQGIYFADDLEDIKALLATVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XPL2</accession>
    <name>A0A173XPL2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_00369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580036.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52515">
        <property type="protein sequence ID" value="CUN52515"/>
        <property type="gene ID" value="ERS852478_00369"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="291"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN52515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="392" mass="44936" checksum="E825A3F4BBA82D29" modified="2016-09-07" version="1">MYSILIIDDEPIVKIALRSILPWEEHGFFICGTASNGLEAVPLIEKHHPDIIITDLKMPEMDGLELIRFLKEKEYPGEILVLSNYEDFDSVRSALLLGAADYLLKIKIQPDTLLACLNKTTKKMQNTADRKDSILKTDITEPITDHLLSFFQGEESLDSFIERYGAEKFGFMKHSCAVCYVTFEKFLSNDAFSISANLLRDMILDAVQGVLQPYILVLSAHNALVVFSQKELMCSQVKVEQLIKKLYNRFTMYQAFAPDMPYKENLKNYEEARTTYQDFLHSEGHYKNDVAKTLTYIENNYMHRLTLSSISANVNLSTSYLCRVFKSEVGTSITSYLNNLRIRKAATLIKENTFSLKEISVMVGIDDQLYFSRLFKKCMGISPSEYGKRFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XWW0</accession>
    <name>A0A173XWW0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">macB_2</name>
        <name evidence="5" type="ORF">ERS852478_00472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199655.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56532">
        <property type="protein sequence ID" value="CUN56532"/>
        <property type="gene ID" value="ERS852478_00472"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN56532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="243" mass="26942" checksum="C0F0930AD0D633B0" modified="2016-09-07" version="1">MGEALIRVKDLCKIYNPGENEVRALDHINLEIDKGEFVAIIGQSGSGKSTFMNMLGCLDVPTSGEYFLNGTDVSTMEDNELSEVRNREIGFIFQGFNLISNLTAIENVELPLVYRGVDRKTRHKLAVESLTMVGLEKRMDHKPNEMSGGQQQRVAIARAIAAQPPVILADEPTGNLDSASSKEILQILKNMHEQGKTVILITHDNGIAAQARRVVRIIDGKIESDFVNENYGKEEYVKNQLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y268</accession>
    <name>A0A173Y268_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199676.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57326">
        <property type="protein sequence ID" value="CUN57326"/>
        <property type="gene ID" value="ERS852478_00496"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032U1S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN57326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="63" mass="7251" checksum="5EBA2C00D1A68261" modified="2016-09-07" version="1">MEVKSILIKDTTREERKQIVEESFGNISASCDGCMAGLAEMYQEYIDGTKEIRDINMEFNQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YQ46</accession>
    <name>A0A173YQ46_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">def1</name>
        <name evidence="2 5" type="synonym">def</name>
        <name evidence="7" type="ORF">BWLFYP14_01785</name>
        <name evidence="3" type="ORF">ERS852478_00736</name>
        <name evidence="4" type="ORF">ERS852523_00607</name>
        <name evidence="6" type="ORF">GT712_03075</name>
        <name evidence="5" type="ORF">GT728_03850</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP11945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706495.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000016_gene3678"/>
    <dbReference type="EnsemblBacteria" id="CUN66291">
        <property type="protein sequence ID" value="CUN66291"/>
        <property type="gene ID" value="ERS852478_00736"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11945">
        <property type="protein sequence ID" value="CUP11945"/>
        <property type="gene ID" value="ERS852523_00607"/>
    </dbReference>
    <dbReference type="GeneID" id="66493511"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN66291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP11945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL32350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS88094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX64996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="158" mass="17479" checksum="BC6ECAAC153C579B" modified="2016-09-07" version="1">MALRKIRLQGDEVLAKVSRPVEKMTPRIHDLIGDMLETMYDAMGVGLAAPQVGMLKRIVVIDIGEGPIVLINPEILETSGEQTGDEGCLSVPGMAGQVTRPNYVKVKALDEDMNEVEYEGEGLLARAFCHEIDHLDGHMYTELVEGELHQVSYDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YX65</accession>
    <name>A0A173YX65_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">L-arabinose transport system permease protein AraQ</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Maltose transport system permease protein malG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">malG_1</name>
        <name evidence="10" type="synonym">araQ_6</name>
        <name evidence="10" type="ORF">BWLFYP14_01743</name>
        <name evidence="7" type="ORF">ERS852478_00778</name>
        <name evidence="9" type="ORF">GT712_02870</name>
        <name evidence="8" type="ORF">GT728_04055</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">BIOML-A1</strain>
            <strain evidence="9 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380254.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67826">
        <property type="protein sequence ID" value="CUN67826"/>
        <property type="gene ID" value="ERS852478_00778"/>
    </dbReference>
    <dbReference type="GeneID" id="66493552"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="80"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN67826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL32391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS88053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX64911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="287" mass="32115" checksum="564F91B6AF79CEC7" modified="2016-09-07" version="1">MNEKNSKNKKGMSMKGQRTLAYIVLIIISFFCLFWFYVLFINATRSNGALKKGFTAIPGGHLIENWKNLLAGTLPVWNGMFNSIFIATCSAVLCTYFSTMTAYAIHAYNFKAKKFMFTFILAVMMIPTQVTALGFLQLLGKIGLDDSFVPLIVPSIAAPVTFFYMKQYMESNLPLELVEAARIDGSGEFNTFNKIVFPLMKPAIAVQAIFTFVQSWNNYFIPALVLHSDKKKTLPVLIAQLRSADFLKFDMGQVYVMIAFSIFPVIIVYILLSRFIVEGVSAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YX68</accession>
    <name>A0A173YX68_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4428 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199798.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68130">
        <property type="protein sequence ID" value="CUN68130"/>
        <property type="gene ID" value="ERS852478_00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027872">
        <property type="entry name" value="DUF4428"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14471">
        <property type="entry name" value="DUF4428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4428" evidence="1">
        <location>
            <begin position="8"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN68130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="359" mass="39857" checksum="C1A40D872B480CE2" modified="2016-09-07" version="1">MGLFDKKICDICGEKIGLLGNRKLDDGNLCKDCAKKLSPWFEERRHSTVEDIKRQLEYREKNKKAVMDFCITRQINTRNYNVFIDDNKGNFTVARKLDVNENPDIVPLSAIVQCRVDVDQQQHEETYTKDGETVSYQPPVYKYEFDYTMRIKVRTQWFDDMDFRLNTFSISSDNRRELMEVEQTAYQIIAALTPNAAGMQSGMSGMNMTGGMQSGMPGMNMNGGMQSGMPGMNMNGGMQSGMPGMNMNAGMQHGMSGMNMNAGMQPGMTGMNMNGGMQSGMPGMNMNVGMQHGMPGMNMNGGMQSGMPGMNMNGGMQQTGMSETNMTGGMQQNNSSWKCQCGAENTGKFCEYCGQPRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YYM4</accession>
    <name>A0A173YYM4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucuronide permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">uidB_1</name>
        <name evidence="4" type="ORF">ERS852478_00820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199821.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69281">
        <property type="protein sequence ID" value="CUN69281"/>
        <property type="gene ID" value="ERS852478_00820"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001927">
        <property type="entry name" value="Na/Gal_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00792">
        <property type="entry name" value="gph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN69281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="454" mass="50851" checksum="BC42D0AC6D930D56" modified="2016-09-07" version="1">MESKNENVKVPLISKIAYGFGDVGCNFSWMFVSNFLMIFYTDVFGISMAAVSALMLFSRFWDAINDPIVGGLTDKTKTKWGRYRPWLLIAAPITAVLLIMTFWAHPDWSDRSKVIYMVITYCLLVLGYTCVNIPYGTLCGAMTQDIDERAKINTSRSVSAMVAIGIINIITVPLIGKLGSQSAKTGYLLVAIIYGCIFAACHFFCFAKTKEQVIMPEKEKISIKVQLRAVMQNRPYILALIGQVLFGFTLYGRNADVLYYFTYVEGNASYYTTYSMCIIIPSIIGAACFQSVFRKLNNKGRTASIFALLTGISMLCMFFFNVKETPAAFYTLAGITQFFFSGFNTAIYAIIPDCVEYGEWKTGLRNDGFQYAFVSLGNKIGMAIGTALLAALLGKYGYVANQVQNPAVLSIMRHSFTTIPGVLWIVTAIVLFFYRLNKKRYNEIVEDLKKNRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YZ74</accession>
    <name>A0A173YZ74_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ECF RNA polymerase sigma factor SigW</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">RNA polymerase factor sigma-70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sigW_4</name>
        <name evidence="5" type="ORF">BWLFYP14_01704</name>
        <name evidence="4" type="ORF">ERS852478_00808</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199806.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68907">
        <property type="protein sequence ID" value="CUN68907"/>
        <property type="gene ID" value="ERS852478_00808"/>
    </dbReference>
    <dbReference type="GeneID" id="66493603"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="118"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN68907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="179" mass="20914" checksum="3CD3EA8D81CEA183" modified="2016-09-07" version="1">MTDEAELLQRLRNREKNSIDEAIQIYTPYLSTVLYHMAGNSLPKEDIEEIVADVFIVLWKNAGRIDLQKGTLRSYLAAVARNFALKRINRKTDHTFLEDIELSDGKNFIEENFHNNYVWETVMSLGEPDSEIFVRRYKFDEKIKDISKAMGLNISTVKTRLSRGKRKLRKMLSNAEERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z0V5</accession>
    <name>A0A173Z0V5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Staphylococcal virulence regulator protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_5</name>
        <name evidence="2" type="ORF">ERS852478_00823</name>
    </gene>
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        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199813.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69379">
        <property type="protein sequence ID" value="CUN69379"/>
        <property type="gene ID" value="ERS852478_00823"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="283"/>
            <end position="305"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="356"/>
            <end position="378"/>
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            <end position="414"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN69379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="446" mass="48322" checksum="CDAC00EA2DF6512F" modified="2016-09-07" version="1">MKTKIQDMTSGSPGRLIILFAIPLMLGNICQQLYTMVDTMVVGQVAGVEALAALGAVDFLMWVVTGISTGLTQGFSIQLSQYYGAKDFDNLRKSLAHSYRLTAFIAAGVLILSQSFASLVLTGLHTPSNIIGMSLLYLRIIFCGIPATAAYNMFASALRAMGNSKTPLTAMIIASVLNVSLDILFVAGFGWGVAGAAIATVIAQSFSAVYCFLILRRIDIVHLTRADFMPASGMNARLMKLGIPVVFQNIIIGVGGLVVQYVINGYGFLFVAGFTATNKLYGLLEMAAISYGYAIVTYVGQNLGARKIDRIRQGVRSSMLLSLLTSLIISAAMFLFGKNILSLFISGEPQQTQQVLAIAFKYLSIMAAMLWVLYFLYVYRSALQGLGDTLMPMVSGMAEFVMRISAALILPHFIGQDGIFFAEIAAWSGATVILCISYYVRMHKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z907</accession>
    <name>A0A173Z907_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prs_1</name>
        <name evidence="6" type="synonym">prs</name>
        <name evidence="5" type="synonym">prs_2</name>
        <name evidence="8" type="ORF">BWLFYP14_01251</name>
        <name evidence="4" type="ORF">ERS852478_00869</name>
        <name evidence="5" type="ORF">ERS852523_02476</name>
        <name evidence="7" type="ORF">GT712_08035</name>
        <name evidence="6" type="ORF">GT728_01080</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">2789STDY5834863</strain>
            <strain evidence="5 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 13">BIOML-A1</strain>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000026">
        <property type="protein sequence ID" value="CUP69211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS89018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706950.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000023_gene1797"/>
    <dbReference type="EnsemblBacteria" id="CUN71675">
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        <property type="gene ID" value="ERS852478_00869"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP69211">
        <property type="protein sequence ID" value="CUP69211"/>
        <property type="gene ID" value="ERS852523_02476"/>
    </dbReference>
    <dbReference type="GeneID" id="66492995"/>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="3">
        <location>
            <begin position="18"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN71675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP69211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL31824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS89018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX64135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="395" mass="44802" checksum="5578D99DEF78E14C" modified="2016-09-07" version="1">MAQATTKDLTTLPVGRLGLIPLISCKDLGEKVNEWLIQWRKERSHEELDSFAFEGYQRESYLIPVQTARFGSGEAKCTIMESVRGDDIYLMVDVCNYSLTYSIGPYENLMSPDDHFQDLKRVIGAIGGKARRVNVIMPYLYESRQNIRSGRESLDCATALQELVSMGVENIITFDAHDARVQNATPLHGFETIQPSYQFIKALLNHEKGLHIDNDHFMIISPDEGSMNRAIYLANILGVDMGMYYKRLDYSKRINGRHPIAAYEFLGPNLKGKDMILIDDMISSGDTVLKISSLLKERGAGRIYICSTFGLFTNGLEKFDEAHKAGVFDKLLTTNLIYQSPELLAKDYYISCDMSKYIALIIDTLNHDQSVSYLLNPVDRINRCVSNYMAQYDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z973</accession>
    <name>A0A173Z973_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exonuclease subunit SbcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380048.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71728">
        <property type="protein sequence ID" value="CUN71728"/>
        <property type="gene ID" value="ERS852478_00871"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN71728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="350" mass="40184" checksum="7CECEFB12FA46C1B" modified="2016-09-07" version="1">MRFIHLADVHLGAVPDRGCPWSSRREEEIWETFRRVIAGIRENPVDLLFIAGDLFHRQPLLRELKEVNNLFSTIPDTRVYLMAGNHDYIKADSFYRDFQWEKNVTFFKNEQLTCVKDEKLDVYVYGLSYEHQEIENPLYDSIHPAEGEGVHILLAHGGDAKHIPMNIKSIAASGFDYIALGHIHKPQILIRDNAAYAGALEPVDRNDLGDHGYIEGHLENGRLKTNFVPFACRSYEQILLMLREDSTQASLEDMLKADLANKGRMNIYRIVIQGTRAPELLLLPERLKSFGYVTEVLDESKPSYDLEALQKKYSGTLIGDYISYFLEKDRNAVEEKALYYGLQALLETSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZAV9</accession>
    <name>A0A173ZAV9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Holin, BlyA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_01274</name>
        <name evidence="3" type="ORF">ERS852478_00892</name>
        <name evidence="5" type="ORF">GT712_08150</name>
        <name evidence="4" type="ORF">GT728_01195</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">BIOML-A1</strain>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS89041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993262.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72328">
        <property type="protein sequence ID" value="CUN72328"/>
        <property type="gene ID" value="ERS852478_00892"/>
    </dbReference>
    <dbReference type="GeneID" id="66493018"/>
    <dbReference type="eggNOG" id="ENOG5033BI9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031564">
        <property type="entry name" value="Flp1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16982">
        <property type="entry name" value="Flp1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Flp1_like" evidence="2">
        <location>
            <begin position="17"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN72328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL31847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX64181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="66" mass="7401" checksum="17DAF075C9E1D055" modified="2016-09-07" version="1">MGQLIRQIKKKNGLIRRFAEEEDAVGVVEIILILVVLIGLVIIFKEQLTELVQSILSKIAKQSNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZD92</accession>
    <name>A0A173ZD92_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">malP_1</name>
        <name evidence="11" type="ORF">ERS852478_00947</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059460.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74007">
        <property type="protein sequence ID" value="CUN74007"/>
        <property type="gene ID" value="ERS852478_00947"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN74007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="755" mass="86023" checksum="B2452D6A4714FBDB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZFV2</accession>
    <name>A0A173ZFV2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione-binding protein gsiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gsiB_1</name>
        <name evidence="5" type="ORF">ERS852478_00979</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74987">
        <property type="protein sequence ID" value="CUN74987"/>
        <property type="gene ID" value="ERS852478_00979"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
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        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016840" evidence="3">
        <location>
            <begin position="28"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="81"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN74987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="519" mass="57399" checksum="BB8F76C7A365B3A3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZKJ7</accession>
    <name>A0A173ZKJ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4956 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01416</name>
        <name evidence="2" type="ORF">ERS852478_01033</name>
        <name evidence="4" type="ORF">GT712_17250</name>
        <name evidence="3" type="ORF">GT728_13635</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000034">
        <property type="protein sequence ID" value="MZL34219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000049">
        <property type="protein sequence ID" value="MZS90756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707171.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76741">
        <property type="protein sequence ID" value="CUN76741"/>
        <property type="gene ID" value="ERS852478_01033"/>
    </dbReference>
    <dbReference type="GeneID" id="66493826"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032531">
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    </dbReference>
    <dbReference type="Pfam" id="PF16316">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN76741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="223" mass="25011" checksum="180BD3B798FCEACD" modified="2016-09-07" version="1">MSVQDMIKKSVLESGMFSQYDIPKILAALAVALILGSVIYLVYQKFYVGVIFSRSFAVTLVGMTVLTCMVTLAISSNIVISLGMVGALSIVRFRTAIKDPMDLLYLFWAITSGITAGAGMYALTLLTAVIIILMITLFYHKQQNGRIYIAVIHYQGTQAGDEIIRCFGKRKYFVKSKTMRNEKTEMAVEIYCRQNDMEFMEKIRDIGGVEDVTLIQYNGEYHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZYP7</accession>
    <name>A0A173ZYP7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CotJB protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Spore coat protein CotJB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_03101</name>
        <name evidence="2" type="ORF">ERS852478_01133</name>
        <name evidence="3" type="ORF">ERS852523_00454</name>
        <name evidence="4" type="ORF">GT712_03430</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP07119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704137.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000108.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2169"/>
    <dbReference type="EnsemblBacteria" id="CUN81344">
        <property type="protein sequence ID" value="CUN81344"/>
        <property type="gene ID" value="ERS852478_01133"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07119">
        <property type="protein sequence ID" value="CUP07119"/>
        <property type="gene ID" value="ERS852523_00454"/>
    </dbReference>
    <dbReference type="GeneID" id="66493969"/>
    <dbReference type="eggNOG" id="ENOG5032Y4N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024207">
        <property type="entry name" value="CotJB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016571">
        <property type="entry name" value="Spore_coat_assembly_CotJB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12652">
        <property type="entry name" value="CotJB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010606">
        <property type="entry name" value="Spore_coat_CotJB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <feature type="domain" description="CotJB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN81344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP07119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="91" mass="10727" checksum="95F3013E37B9AC28" modified="2016-09-07" version="1">MKTDCSQKQLLNRIDQVSFAVNDMTLYLDTHPCDEKALTYCHELVQERKKLLKEYAEAYGPLIIDITDQTGESIWKWMEQPFPWEKEGACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AFU0</accession>
    <name>A0A174AFU0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Predicted outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_01269</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199996.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87264">
        <property type="protein sequence ID" value="CUN87264"/>
        <property type="gene ID" value="ERS852478_01269"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041033">
        <property type="entry name" value="Prealbumin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013552">
        <property type="entry name" value="Thioester_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17802">
        <property type="entry name" value="SpaA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08341">
        <property type="entry name" value="TED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017652" evidence="2">
        <location>
            <begin position="31"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="domain" description="TED" evidence="3">
        <location>
            <begin position="80"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="4">
        <location>
            <begin position="325"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="4">
        <location>
            <begin position="505"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="4">
        <location>
            <begin position="706"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="4">
        <location>
            <begin position="835"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="4">
        <location>
            <begin position="954"/>
            <end position="1026"/>
        </location>
    </feature>
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        <location>
            <begin position="1059"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="4">
        <location>
            <begin position="1159"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="domain" description="SpaA" evidence="4">
        <location>
            <begin position="1265"/>
            <end position="1327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN87264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1380" mass="149762" checksum="9A29964B8507BF1B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ALJ5</accession>
    <name>A0A174ALJ5_9FIRM</name>
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        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_11</name>
        <name evidence="7" type="ORF">ERS852478_01334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
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        <property type="protein sequence ID" value="CUN89631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381105.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89631">
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        <property type="gene ID" value="ERS852478_01334"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="101"/>
        </location>
    </feature>
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        <location>
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        <location>
            <begin position="78"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUN89631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AXE0</accession>
    <name>A0A174AXE0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01412</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200067.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93257">
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        <property type="gene ID" value="ERS852478_01412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN93257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="74" mass="9154" checksum="C8E751841645CF9B" modified="2016-09-07" version="1">MKIYKAVHERENKCKELHKEMNLNVGPTRLVQPDFYLLVDVDDIQRQMNALENEVHRIKRAEVRRRWRYGRKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AXJ4</accession>
    <name>A0A174AXJ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN92853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN92853">
        <property type="protein sequence ID" value="CUN92853"/>
        <property type="gene ID" value="ERS852478_01399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN92853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="145" mass="16395" checksum="E021B91BD2D5801A" modified="2016-09-07" version="1">MKIIKISTELEMTIHDFPEGTMREQSKALYELIGNGCDIVEHVMPKRLYTMLKMSPTPTRTPGECVCMLIDEEGRLKPNRANLIGSYLYEYDKHGCPILGNILFIGEKMGNSGIDFCGISEENFDCLKKGLVNMFPVIKVTEVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AZ09</accession>
    <name>A0A174AZ09_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN92628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200050.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN92628">
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        <property type="gene ID" value="ERS852478_01391"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
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    </dbReference>
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        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018021" evidence="2">
        <location>
            <begin position="27"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN92628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="379" mass="41135" checksum="9EF54EF3F1B750DE" modified="2016-09-07" version="1">MKKKILSALFFSFIATFVLPISQLNAKDNVSDFSYVENHEVSLPFFFGERTGLYTGSIKNGLPCGVGEFKTQNTDGVSWIYIGEWIDGHLEGKGTSFFDNGDIKTGTYSKDYLSGDKCLMSSSAGTYFGELNNEIASGKGTSLTLTERYVGEFKDNLYGGYGTLYYENGQRYEGNFSNGQINGDGSFFFTDGSHVTGSFATNKDTGLLDGEGIFYYANGTSNDCIYESGNIIFPNSEPIASSTPIPTPSPVPTPFSSPTPVPSSLSEADQRLANATIFKADVYNGTGTDIIGKRAYIIIPKDTLKQISEKDYANFLNTKVKDSGYNWFSIICDDGTGICFAGSFTNLGTYGKINKDGSITEAIGNISATENGYKYEPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B3Y4</accession>
    <name>A0A174B3Y4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysM domain/BON superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704594.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94446">
        <property type="protein sequence ID" value="CUN94446"/>
        <property type="gene ID" value="ERS852478_01450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="171"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN94446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="233" mass="26744" checksum="07412CC686D06C8F" modified="2016-09-07" version="1">MEIYLKEAANKQSCLRFPSLPDKEITVKGNSKYQKYDLIKKGTFAFPAGPDIRSYEWDGYLWGRARKKMSTIHTKWLDPKSVIKKLENWRDKGTVLNLIISAGGGINVDVTINSFEYKKFGGKGDYFYSISFYRYRPLKIQTTKDLGIDKKKKKTTARTNLKKSSTDKKKQTYTIKTGDCLWNIAKKFYGSGADWKKIYDANKTAIEKAAKKYGHKDSNQGDWIFPGTILTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B727</accession>
    <name>A0A174B727_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Asp23/Gls24 family envelope stress response protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF322)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_00971</name>
        <name evidence="2" type="ORF">ERS852478_01507</name>
        <name evidence="3" type="ORF">ERS852523_00772</name>
        <name evidence="5" type="ORF">GT712_13015</name>
        <name evidence="4" type="ORF">GT728_11040</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP17020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000024">
        <property type="protein sequence ID" value="MZL33719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000026">
        <property type="protein sequence ID" value="MZS89966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993850.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1361"/>
    <dbReference type="EnsemblBacteria" id="CUN96474">
        <property type="protein sequence ID" value="CUN96474"/>
        <property type="gene ID" value="ERS852478_01507"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17020">
        <property type="protein sequence ID" value="CUP17020"/>
        <property type="gene ID" value="ERS852523_00772"/>
    </dbReference>
    <dbReference type="GeneID" id="66492595"/>
    <dbReference type="eggNOG" id="COG1302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN96474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP17020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX63485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="119" mass="12802" checksum="F9E3F63FA2AC8FEB" modified="2016-09-07" version="1">MNGRIDSGLGQIIIDTDVIATYAGSVAVECFGIVGMAAVSMKDGLVKLLGKNSLKHGISVRITEDNKIRLNFHVIVAYGVNISTIADNLVSNVKYKVEAFTGMEIDKIDIYVEGVRAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B780</accession>
    <name>A0A174B780_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Double zinc ribbon</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BWLFYP14_00965</name>
        <name evidence="7" type="ORF">ERS852478_01513</name>
        <name evidence="8" type="ORF">GT712_12985</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000026">
        <property type="protein sequence ID" value="MZS89961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704309.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96677">
        <property type="protein sequence ID" value="CUN96677"/>
        <property type="gene ID" value="ERS852478_01513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="SSF90209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN96677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS89961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX63479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="153" mass="17676" checksum="CF3CCBEFB640B57B" modified="2016-09-07" version="1">MGKIIEGLWDCPFCGNKRIRAGQKTCPDCGHPQDENTKFYMPDEIKYVSEEEAEKISRNPDWQCSFCGSLNSDDLNVCKNCGATKEDSERNYFEMRQQEEEKKRKKEEKKESCQKNIPQNTPKKKPLLRRVLLILGIFAAIIFGMMSCLAPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B8C0</accession>
    <name>A0A174B8C0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_00957</name>
        <name evidence="1" type="ORF">ERS852478_01520</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96924">
        <property type="protein sequence ID" value="CUN96924"/>
        <property type="gene ID" value="ERS852478_01520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038021">
        <property type="entry name" value="Putative_hydro-lyase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160920">
        <property type="entry name" value="SSF160920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN96924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX63471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="64" mass="7120" checksum="D743F4988E93A9DA" modified="2016-09-07" version="1">MAFDITPYVDMSPKKVRELIRKGVIDFPTAGMCRGYAQANMDAGISSMTASISIVRNEILFLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BBH8</accession>
    <name>A0A174BBH8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4366 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_01535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200130.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97539">
        <property type="protein sequence ID" value="CUN97539"/>
        <property type="gene ID" value="ERS852478_01535"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025376">
        <property type="entry name" value="DUF4366"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14283">
        <property type="entry name" value="DUF4366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018288" description="DUF4366 domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4366" evidence="4">
        <location>
            <begin position="67"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN97539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="253" mass="27103" checksum="62DC2D86F6BFDED2" modified="2016-09-07" version="1">MKKSKLFRTLTLAVAAALCMATTTVTAYAGGADPDPVPLPETTEAPAEVPEETEEPTTGGMEPVGVPVTPQGNATLVDDFFGDKQLITVTTKAGNYFYILIDRANEDKETAVHFLNQVDDADLQALLEDGKKEPEVCNCTAKCQAGAVNTACPVCKNNLTACNGPEPKPQPEEEKPQEEKPSGMGGLVVFFVVVLLGGGAALYFLKFKKEKADTTGNDDLAEYDFGEDEDDEDEAPEPDEDMTSEDGNKEDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BI97</accession>
    <name>A0A174BI97_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Predicted outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_01596</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057310.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00437">
        <property type="protein sequence ID" value="CUO00437"/>
        <property type="gene ID" value="ERS852478_01596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041033">
        <property type="entry name" value="Prealbumin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17802">
        <property type="entry name" value="SpaA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018465" evidence="6">
        <location>
            <begin position="33"/>
            <end position="2097"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2071"/>
            <end position="2090"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="7">
        <location>
            <begin position="2062"/>
            <end position="2097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2036"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO00437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="2097" mass="231560" checksum="8CE99ECE9B56023F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BJE3</accession>
    <name>A0A174BJE3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation initiation inhibitor protein soj</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">soj_2</name>
        <name evidence="2" type="ORF">ERS852478_01578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057300.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99850">
        <property type="protein sequence ID" value="CUN99850"/>
        <property type="gene ID" value="ERS852478_01578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="2"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN99850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="264" mass="29243" checksum="7FF5F6BE074A8498" modified="2016-09-07" version="1">MAKVIAIVNQKGGVAKSTSCVNLGIGLVKKGYKVLAIDFDPQGSLTESLGYQNPDELEITVATILHCEMNGLELSEGYGILHHEEGMDILPANIELSGVEVSLVNVMSREYVLKQFIKTISPEYDYILIDNMPSLGMLTVNALAAADSVIIPVMAHYLPVKGLEQLMQTIYKVRKQINRKLQIDGILLTMVDRRTNFSKEIIELLHDNYGEYINIFKTAIPFSIRAAETSAEGVSIYKHDPKGRVAEAYKKLVEEVIGDGSERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BK64</accession>
    <name>A0A174BK64_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lipid A export ATP-binding/permease protein MsbA</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">msbA</name>
        <name evidence="10" type="ORF">ERS852478_01620</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_024720761.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01402">
        <property type="protein sequence ID" value="CUO01402"/>
        <property type="gene ID" value="ERS852478_01620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="22"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="334"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="366"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO01402.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="578" mass="62970" checksum="AB7A40C92C920766" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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        </submittedName>
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            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01962">
        <property type="protein sequence ID" value="CUO01962"/>
        <property type="gene ID" value="ERS852478_01639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO01962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="143" mass="16282" checksum="1EA9DAD4AE493A76" modified="2016-09-07" version="1">MKKKIIALISGAVILIIAAGSIYGKSESGHEEGEPDVVGTFSVNRDENLTVVANRKNIEDREAFVRELLQMYKDDSFYSTKFSTDRGYATSLDMNIYLWKEDIEDGESVMTAEYRPVEYGKDYDVVNNPDKFQLYIDGKEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BSH6</accession>
    <name>A0A174BSH6_9FIRM</name>
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        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rplC</name>
        <name evidence="13" type="ORF">BWLFYP14_00255</name>
        <name evidence="9" type="ORF">ERS852478_01657</name>
        <name evidence="10" type="ORF">ERS852523_01295</name>
        <name evidence="12" type="ORF">GT712_08990</name>
        <name evidence="11" type="ORF">GT728_04690</name>
    </gene>
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        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707247.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2984"/>
    <dbReference type="EnsemblBacteria" id="CUO02588">
        <property type="protein sequence ID" value="CUO02588"/>
        <property type="gene ID" value="ERS852478_01657"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33696">
        <property type="protein sequence ID" value="CUP33696"/>
        <property type="gene ID" value="ERS852523_01295"/>
    </dbReference>
    <dbReference type="GeneID" id="66496120"/>
    <dbReference type="eggNOG" id="COG0087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CUO02588.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZS89203.1"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="VUX67414.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="210" mass="22664" checksum="2A0AD0858DEFC5BA" modified="2016-09-07" version="1">MKKAILATKVGMTQIFNEDGQLIPVTVLQAGPCVVTQVKTEENDGYEAVQVGFGDIRESLVNKPEKGHFDKAGVAVKRFVKEFRFDNAAEYTVGQEIKADIFADGDHIDATAVSKGKGFQGAIKRHGQSRGPMAHGSKYHRHAGSNGACSDPSKVFKGKHMPGHMGNVQVTVQNLEIVRVDTENNLLLVKGAVPGPKKSLVTIKETVKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BU87</accession>
    <name>A0A174BU87_9FIRM</name>
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        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <name evidence="11" type="ORF">BWLFYP14_00273</name>
        <name evidence="7" type="ORF">ERS852478_01675</name>
        <name evidence="8" type="ORF">ERS852523_01277</name>
        <name evidence="10" type="ORF">GT712_08900</name>
        <name evidence="9" type="ORF">GT728_04780</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
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            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707273.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2966"/>
    <dbReference type="EnsemblBacteria" id="CUO03240">
        <property type="protein sequence ID" value="CUO03240"/>
        <property type="gene ID" value="ERS852478_01675"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33110">
        <property type="protein sequence ID" value="CUP33110"/>
        <property type="gene ID" value="ERS852523_01277"/>
    </dbReference>
    <dbReference type="GeneID" id="61848989"/>
    <dbReference type="GeneID" id="66496138"/>
    <dbReference type="eggNOG" id="COG1841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="6">
        <location>
            <begin position="5"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO03240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP33110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL32534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS89185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX67432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="60" mass="6508" checksum="F76F548106255663" modified="2016-09-07" version="1">MANTLKVTLVKSPIGAVPKHKKTVAAMGLTKMHKTVEMPDNAATRGMIQQVQHLVKVEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BZ12</accession>
    <name>A0A174BZ12_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized deoxyribonuclease YcfH</fullName>
            <ecNumber evidence="1">3.1.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ycfH</name>
        <name evidence="1" type="ORF">ERS852478_01735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.21.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200202.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05943">
        <property type="protein sequence ID" value="CUO05943"/>
        <property type="gene ID" value="ERS852478_01735"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO05943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="259" mass="29397" checksum="08AD2FA2A2C6402D" modified="2016-09-07" version="1">MIIDTHAHYDDEAFDTDREALLTSMYDGGIEKIVNVCASVGSFQDTVDLMEKYPFIYGAVGIHPDDADKMTQETLDEICRLSHMDKMVAIGEIGLDYYWHKEEEEHQIQQKMFRAQLDIAREEKLPFMIHSREAAEDTLNIVREYMQGGMYGGIIHCFSYSREIAAEYLKMGLYLGIGGVVTFKNAKKLKETVQYAPLSQLVLETDCPYMSPEPNRGKRNSSLNLPYVAQAIAELKGITAEEVIDVTRQNAEKLLGIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C0A8</accession>
    <name>A0A174C0A8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arylsulfatase</fullName>
            <ecNumber evidence="7">3.1.6.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_01747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200219.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06297">
        <property type="protein sequence ID" value="CUO06297"/>
        <property type="gene ID" value="ERS852478_01747"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="DUF4976"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="DUF4976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4976" evidence="6">
        <location>
            <begin position="337"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO06297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="495" mass="57250" checksum="51CB98C63FCBD433" modified="2016-09-07" version="1">MRKQLIFLMTDTTRKDMVGCYGNPKMKTPNLDRLAEEGIRYENAYTCQPVCGPARSAIFTGTFPHTNGMVTNSIAMGDNVKTVGQRLSDNGIACGYIGKWHLDGSDYFGNGRCPDGWDSDYWYDMKTYLNELSDEDKVKSRDPKEAYKEGFSEEFTYAHRCSDRAIKYLEEHKDEDFFLSVSYDEPHGPSLCPAPFNHMYDGFRFDSCPNFQDDLSKKPFMQRLWSGKNLHAAEDEINKPSDGLSLFLGCNSFADYEIGRVLDKIKEVAPDAMVIFTSDHGDMLGAHRLFSKNAAAYREVANIPLIIKGGAKGCVEDAMASHIDIAPTIMDYFGLPIPKLLEGKSMLPQIYEPSREINDVVYTEFTRYELDHDGFGGLQIMRAVMSKRYKLVIHLLDSDEFYDLEKDPYEMNNLIDDETYTEIRNEMHDRLIEHMNSTRDLYRGYQWRMRPWRKDFIPNWENEGYTRQRENEEYEPRQLDYDTGLPMESSVRKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C5F3</accession>
    <name>A0A174C5F3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="3">2.6.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glmS_2</name>
        <name evidence="3" type="ORF">ERS852478_01812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.16" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200293.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08374">
        <property type="protein sequence ID" value="CUO08374"/>
        <property type="gene ID" value="ERS852478_01812"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="33"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="198"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO08374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="353" mass="39925" checksum="83499006D731F665" modified="2016-09-07" version="1">MKKNSELTYKEMYRQPASFQAVNDTLEDIFKTLDKVFFSEKKYDELIFTGCGTSLYLAQASAAAFSTYTGIPSKGVPCSELYYFPETYVKEGRNVLILPITRKSYTTEVRMAIDKVRTYPQVTTLAITCDKDSEKYNDYYILSPDTAEDSVIMTRSFTSMLYMAVIMAMYVGGKKDEIAAMKDYAPYSEKVLKEMDELSTKIMNEHKNLNLYIILGQGIYYGVANECMNKMKEMGLSNSEGYYDLEYRHGPMSLVDENTLIVCLSNKACRDGDKALMEQMKSYGATVAVLGGELGDTFDQIADYVYSMDKGWNDMQYSAIIGFIGQLLGYYIADSKNLDADSPRHLTQAIVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C8P8</accession>
    <name>A0A174C8P8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070102123.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08076">
        <property type="protein sequence ID" value="CUO08076"/>
        <property type="gene ID" value="ERS852478_01803"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZW3A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO08076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="179" mass="19586" checksum="47CB770CCC603050" modified="2016-09-07" version="1">MKENTALRKKILAALFLAIGLILPFITMQIPAVGKMLCPMHIPVLLCGYICGWPYGLLIGIITPLLRGVLFGMPAIFPNAFCMAFELATYGLVAGILSEKMKKDIKSLYISLIAAMLCGRIVWGLVSAAVYAFTGGIFTWELFLMGGFINALPGILIQLVLIPALVERLYNMEGTVEWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C9B7</accession>
    <name>A0A174C9B7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein, YkwD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200343.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10082">
        <property type="protein sequence ID" value="CUO10082"/>
        <property type="gene ID" value="ERS852478_01843"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019000" evidence="2">
        <location>
            <begin position="26"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="28"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO10082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="499" mass="54546" checksum="91877489348D0157" modified="2016-09-07" version="1">MKKRRLFLCLLFMLAVMLLPATIQAASAPGTVKLSSISAPAYNKINVKWKKTSGATHYIVYYKKEGTKKWTKIKTLDNSKSSYTHTSSKKYPIVVGQKYIYTVKAYNTKTKKAGYYNKKGLTAYTKPAMVKNIKAAYKDGIVTLTWDKAAGADKYLVYRKDNGKWKMLALKNSLSYEDAAYKKGEVNTYMVRSYYSGKKTKGSYDKDGVSVKVPANAAKPTEKPEPTEKPVIPTPTATPSPKPTKVPEPTEKPVTPTPIATPTPTEKPATPTPTATPIPTATPTPAAPTPTPEMSVEEMASEVIRLTNIERVKAGRSPLQYHAGLQRAAMVRAEEITRKFSHTRPDGTDSSTALYENGVSCSCGENIAAGQKTPEAVVRAWMNSPGHKAAILDPDATHIGVGICKSPITGQWLWVQDFSYNPDIQGTVIFDADGGVFNSNGSNTLAITGPVGKIIYASEIEIPSKEGYSFNGWEENLRSIRIQSRPDKVIATWTPISES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CAU9</accession>
    <name>A0A174CAU9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiosulfate sulfurtransferase PspE</fullName>
            <ecNumber evidence="3">2.8.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pspE_2</name>
        <name evidence="3" type="ORF">ERS852478_01859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.8.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200373.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10572">
        <property type="protein sequence ID" value="CUO10572"/>
        <property type="gene ID" value="ERS852478_01859"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019041" evidence="1">
        <location>
            <begin position="28"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="52"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO10572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="140" mass="15345" checksum="CBCAE445AA07056A" modified="2016-09-07" version="1">MRQILLCAALTTSLALLSGCTLSKTKADTAEDAPGKAAYHKISAEEDYEMMVSQEVVVVDVRTREEYDGGHIENAVLVPNESIGSKMPETLPDKEATLLIYCRSGRRSKDAAQKLLALGYQSVYDFGGVIDWPYELVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CFG4</accession>
    <name>A0A174CFG4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Benzoyl-CoA oxygenase component A</fullName>
            <ecNumber evidence="6">1.14.12.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">boxA</name>
        <name evidence="6" type="ORF">ERS852478_01873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.14.12.21" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200398.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10999">
        <property type="protein sequence ID" value="CUO10999"/>
        <property type="gene ID" value="ERS852478_01873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO10999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="67" mass="7115" checksum="9A1ADCC206A5AF46" modified="2016-09-07" version="1">MLSKKLAVIDKLRCVACGVCENTCPLEAVQVHCGCYAVVQKERCVGCGKCAKLCPVGCIEVKVRADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CSX6</accession>
    <name>A0A174CSX6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartate-semialdehyde dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Aspartate-semialdehyde dehydrogenase 2</fullName>
            <ecNumber evidence="2 4">1.2.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">asd2</name>
        <name evidence="4" type="synonym">asd</name>
        <name evidence="2" type="ORF">ERS852478_01975</name>
        <name evidence="3" type="ORF">ERS852523_00108</name>
        <name evidence="5" type="ORF">GT712_18345</name>
        <name evidence="4" type="ORF">GT728_09055</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A1</strain>
            <strain evidence="5 8">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.11" evidence="2 4"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO14930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO97059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000059">
        <property type="protein sequence ID" value="MZS90953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707510.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2273"/>
    <dbReference type="EnsemblBacteria" id="CUO14930">
        <property type="protein sequence ID" value="CUO14930"/>
        <property type="gene ID" value="ERS852478_01975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97059">
        <property type="protein sequence ID" value="CUO97059"/>
        <property type="gene ID" value="ERS852523_00108"/>
    </dbReference>
    <dbReference type="GeneID" id="66495593"/>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="1">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO14930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO97059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="361" mass="40124" checksum="1F5C959E11B99EC7" modified="2016-09-07" version="1">MSEKLRVGILGATGMVGQRFISLLENHPWFEVVTVAASPRSAGKTYEEAVGGRWKMDTPMPEGVKNLVVMNVNEVEKVAATVDFVFSAVDMSKEEIKKIEEEYAKTETPVVSNNSAHRWTPDVPMVVPEINPEHFDVIESQKKRLGTTRGFIAVKPNCSIQSYAPVLTAWKEFEPYEVVATTYQAISGAGKTFKDWPEMVGNIIPYIGGEEEKSEKEPLRIWGKVEDGVIKPATEPVITCQCIRVPVLNGHTAAVFVKFRKNPTKEQLIKALVEFKGLPQELELPSAPKQFIQYLEEDNRPQVTEDVNFEHGMGVSVGRLREDTVYDWKFVGLSHNTVRGAAGGAVLCAETLKAKGYIQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CX80</accession>
    <name>A0A174CX80_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional oligoribonuclease and PAP phosphatase nrnA</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nrnA_2</name>
        <name evidence="3" type="ORF">ERS852478_02021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200485.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16450">
        <property type="protein sequence ID" value="CUO16450"/>
        <property type="gene ID" value="ERS852478_02021"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="16"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="231"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO16450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="320" mass="35494" checksum="8C74CB2A92FD1928" modified="2016-09-07" version="1">MENIAEILEGVKTMGIGGHIRPDGDCVGSCMALYLYVKTYYPEIQADVYLDNPKPVFGHIDCMDEIKTELDGDKEYDLFVTCDVSAKDRLAIAGPYFDTAKRTACIDHHISNSGFAQVNHIRGEVSSACEVLYGLFDPEKVVRTIAVPIYTGMVHDTGVFQYSSTSPETMRIAGELMKTGFNFSKIIDESFYQKTYVQNQVMGRVLAESILLLDGKCIIGYLKKRDMEFYGVDGKDLDGIVSQLRLTAGVEVAMFIYEVETQSFKVSLRSNGNVDVSKIAVYFGGGGHMRAAGCDLQGSVYDVINNVTEQICKQFQEQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D2N0</accession>
    <name>A0A174D2N0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Cytidine deaminase</fullName>
            <ecNumber evidence="6 11">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cdd</name>
        <name evidence="13" type="ORF">ERS852478_02105</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 11">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="6 11"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19713">
        <property type="protein sequence ID" value="CUO19713"/>
        <property type="gene ID" value="ERS852478_02105"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047844">
        <property type="term" value="F:deoxycytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="12">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO19713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="147" mass="16527" checksum="774F14080D4AE111" modified="2016-09-07" version="1">MQNLEKSMISKLIETAMEQLKFSYTPYSNFKVGASLLTKNGQIYTGCNIENAAYTPTNCAERTAIFKAVSEGVREFDTICIVGGKDGILTEYTAPCGVCRQVMMEFCDPETFRIILAIDKEHYDIYTLKDLLPLGFGLRNLINSREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D8P6</accession>
    <name>A0A174D8P6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">KH domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Predicted RNA-binding protein (Contains KH domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_02183</name>
        <name evidence="9" type="ORF">GT712_11405</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708008.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22132">
        <property type="protein sequence ID" value="CUO22132"/>
        <property type="gene ID" value="ERS852478_02183"/>
    </dbReference>
    <dbReference type="GeneID" id="66493375"/>
    <dbReference type="eggNOG" id="COG1847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038247">
        <property type="entry name" value="Jag_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032782">
        <property type="entry name" value="KhpB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14804">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01245">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="R3H" evidence="7">
        <location>
            <begin position="243"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO22132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="310" mass="35525" checksum="B55691A50D7CB7F1" modified="2016-09-07" version="1">MEDYIQFSAKTKSEAITKACIELGVSSDQLEIQVISEGSNGFFGIGSKPAVIKVRKIESVSEEEEMKEIVETVKLDSFKEEAPVQEEKKTEAIKPVKKEIKEPKAVSEKPRQPKPVKERAAKEKQPREFREPKEKQVREKTTKPVKPVEILTDPEEIKEVENRAKVFLRDVFASMNLGEVEITSEYNTTDGSLEVDFEGEDMGILIGKRGQTLDSLQYLTSLVVNKGKSNYIRVKLDTEDYRKRRKETLENLARGIAYKVRKTRKPVILEPMNPYERRIIHSALQGNKFVETVSEGEEPYRHVVVKLKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DBH7</accession>
    <name>A0A174DBH7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200596.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21408">
        <property type="protein sequence ID" value="CUO21408"/>
        <property type="gene ID" value="ERS852478_02160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO21408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="105" mass="12100" checksum="6DFE44C042A1805D" modified="2016-09-07" version="1">MKIIIIFIDLLMATVLFFVGRFFIKSRNTERSVLFLSGDYTGLNTEKICRVTGKRIKTWSMLFCIGGIIDFIKLGAGIIIVSVFFIILLVFHLVDMTINRDKYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DGZ3</accession>
    <name>A0A174DGZ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004612745.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24871">
        <property type="protein sequence ID" value="CUO24871"/>
        <property type="gene ID" value="ERS852478_02257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO24871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="66" mass="7703" checksum="1B23D921039DA9E4" modified="2016-09-07" version="1">MQVYIDLENLLKEKNISKNKVCEACKLQRTQLNNYCKNKVSRIDLTILAKLCDFLECSPNDILKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DK57</accession>
    <name>A0A174DK57_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore cortex-lytic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200679.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25893">
        <property type="protein sequence ID" value="CUO25893"/>
        <property type="gene ID" value="ERS852478_02288"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020064" evidence="1">
        <location>
            <begin position="28"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="2">
        <location>
            <begin position="130"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO25893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="197" mass="23193" checksum="1C5DDCBF95944DE7" modified="2016-09-07" version="1">MKHNRSKNAMLLMIIFICSICLNNVWARETGTMDQLEKENPDDVDKMNKVLYYYNTLFFENYTEEELKQQEKFQKSIHLLNELYFEYGSLENIPILPFDPENIREGDSLFTEVVAVINTENNETYFVTENDDMKLLKKCLEKLQYYNGNSVTKSNEELTEAIKNFQKEEGLTIDGIAGNEVWRKIDILMLNKVIEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DRP1</accession>
    <name>A0A174DRP1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde-alcohol dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">adhE_2</name>
        <name evidence="3" type="ORF">ERS852478_02309</name>
        <name evidence="4" type="ORF">GT728_12220</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000029">
        <property type="protein sequence ID" value="MZL33944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705567.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26530">
        <property type="protein sequence ID" value="CUO26530"/>
        <property type="gene ID" value="ERS852478_02309"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="8"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO26530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="383" mass="41879" checksum="7736DD0C4B7AFA62" modified="2016-09-07" version="1">MNTFEMKTAIHFGDNALDRLKEIPYKRVLIITDPFVVQSKMINLITAPLNSAGIEYDIFHDVVPDAPVDKIAEGVKKFLEYQPEAVVAVGGGSAIDSSKAIREFALKINNYGKVGLIAIPTTSGTGSEVTSFAVVNDTAAHVKYPLISESLTADEAILDAELVRSVPPAITADTGMDVFTHALESYVSTAHNEFSSALAEKAIEICGVFLLRAYLDGSDMHARKKMHVASCLAGLSFNTAGLGITHSMAHQLGAMFHIPHGRANAMLLPHIVEFNSDINKHSKSQKEYLPAVKRYANVAHILGLSNYNKVMTVRSLVNWIQFMQKEMNIPLTIQELGTIAPEEYFAAIDKMADAALADACTVNNPRVPTKEDIIKIYTKLWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DY87</accession>
    <name>A0A174DY87_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ktr system potassium uptake protein A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TrkA family potassium uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ktrA_1</name>
        <name evidence="5" type="ORF">BWLFYP14_00121</name>
        <name evidence="3" type="ORF">ERS852478_02415</name>
        <name evidence="4" type="ORF">GT712_04380</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053464.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30511">
        <property type="protein sequence ID" value="CUO30511"/>
        <property type="gene ID" value="ERS852478_02415"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="134"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO30511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="215" mass="24339" checksum="3A58AD71E3D6665B" modified="2016-09-07" version="1">MKNVLIIGLGRFGRHIAMQLNQLGHEIMAVDWNEERVDKVLPFVTNAQIGDSTNAEFLQSLGIGNYDICFVTIGGSFQNSLETTSLLKELGAKLVISRAERDVQEKFLLRNGADKVVYPEKQVAKWASIRYTDDHILDYMEVDASHAIFEVEVPEEWTGKTVGGLDIRKRYNINILAVKNEGEFNIAISPDTYLEENSKLLVLGEYRALQKCFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E2H4</accession>
    <name>A0A174E2H4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal kinase</fullName>
            <ecNumber evidence="1">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.35" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060045.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30686">
        <property type="protein sequence ID" value="CUO30686"/>
        <property type="gene ID" value="ERS852478_02421"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PTHR10534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020398" description="Pyridoxal kinase" evidence="2">
        <location>
            <begin position="33"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Phos_pyr_kin" evidence="3">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO30686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="289" mass="31673" checksum="68D4346964A342CA" modified="2016-09-07" version="1">MKKIAVIHDLSGLGKCSLTAAIPVISVMGVQACPLPTAILSNQTGYGSYFWDDYTDRMELIMDEWKKTGFTPDGVYTGFLGDARQVDLILKFVDMFCTEGTHILVDPVMGDRGETYKTYSETLCEKMRTLVREATVITPNLTEALLLLYGEEGMKERMKALSDMEETQLLKEIEKSGRNLTQRFGLEAIVITGVEVSGSDGRARMGNLVLEKEKADWCFSVKEGGSYSGTGDLLASVLSAGMVRGIPMKACVEKAVEFLGGAIHDAVEEGTDRNDGVCFEKYLGILTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E607</accession>
    <name>A0A174E607_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized vancomycin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_02485</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32887">
        <property type="protein sequence ID" value="CUO32887"/>
        <property type="gene ID" value="ERS852478_02485"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038054">
        <property type="entry name" value="LD_TPept-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="PG-bd_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12229">
        <property type="entry name" value="PG_binding_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143985">
        <property type="entry name" value="SSF143985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_4" evidence="5">
        <location>
            <begin position="155"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_4" evidence="5">
        <location>
            <begin position="261"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="379"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO32887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="507" mass="57214" checksum="D35E914096DFB252" modified="2016-09-07" version="1">MMGQSIRTSKSARPGTITYVPIDKSEFRSTVSSDKKKNKIMKIVVMLIVMILVMSCCVYAGISYYYSYHFFLGTTINGIDSSNKTAYEVEQEIAGKKDNYVIQVSARMQEPQTITGKDIDYQYVSSGEILQLLKTQKPWEWIRGFFETKNYMVQEETVFSREKLEEQVSSLNCAKKENQIAPENAYVSFSNSEFTIVPETEGSELNAKEAYQMISRAIDNEAADVDLGSNPKAYKEADVTRDSSELQNMVNMYNGLAKVNITYTFGDETVTLDGNTIKNWLQFDEKGQLLPDDGAFRQHVVDYVAQLAADHDTVGTERQFETTSGRIVYVYGSAYGWKIDQDKEAAQLMQEIQSGTQTTREPVYSMRANAHGINDLGDTYIEVDLTEQYMWYYQNGNIIFQSEIVSGLPGDPDRKTPPGIFTLNSKSSPSVLRGEMTANGTYSYEQPVTYWMPFNGGIGFHDADWQPYFGGDRYLTGGSHGCINLPPENAGQLYSLIQYDVPIICFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EB04</accession>
    <name>A0A174EB04_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic di-GMP phosphodiesterase response regulator RpfG</fullName>
            <ecNumber evidence="3">3.1.4.52</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">HD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpfG_2</name>
        <name evidence="3" type="ORF">ERS852478_02516</name>
        <name evidence="5" type="ORF">GT712_02275</name>
        <name evidence="4" type="ORF">GT728_13310</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A1</strain>
            <strain evidence="5 7">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.52" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000033">
        <property type="protein sequence ID" value="MZL34154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33629">
        <property type="protein sequence ID" value="CUO33629"/>
        <property type="gene ID" value="ERS852478_02516"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071111">
        <property type="term" value="F:cyclic-guanylate-specific phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO33629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS87948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="220" mass="24837" checksum="7D5103F6E7BFF237" modified="2016-09-07" version="1">MDTVQKTAAGSQQRILEFDLASELHHGMLVSNLAYAVAEEMGLPHEQCYELAIAGMLHDIGKLKLTSYINGQEQDPLVIEELKYVRMHSALGYEELKGQGYSDFVLESILYHHENYDGSGYPSNKAGDDIPIGARILRVCDVYAALISDRPYRRGFDISSVMELMIDEVKNFDMQVFLAFQRVVHNGDGQNFYKRGGQHGIKEETGNRYEGHFTKRDGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ECA2</accession>
    <name>A0A174ECA2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Biotin/lipoyl-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Efflux system component YknX</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Multidrug resistance protein MdtN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yknX</name>
        <name evidence="8" type="ORF">BWLFYP14_00506</name>
        <name evidence="5" type="ORF">ERS852478_02511</name>
        <name evidence="7" type="ORF">GT712_02300</name>
        <name evidence="6" type="ORF">GT728_13285</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">BIOML-A1</strain>
            <strain evidence="7 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000033">
        <property type="protein sequence ID" value="MZL34149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000004">
        <property type="protein sequence ID" value="VUX62623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994015.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33510">
        <property type="protein sequence ID" value="CUO33510"/>
        <property type="gene ID" value="ERS852478_02511"/>
    </dbReference>
    <dbReference type="GeneID" id="66495262"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="4">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO33510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL34149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS87953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX62623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="492" mass="53590" checksum="7F7C89C286CA171C" modified="2016-09-07" version="1">MKKRIIIVLGILIAAGGIGTGVWYHFKGNGQSGTGDSIVYVSKVSVITGSETTAVNRFAGVVEPQKTVNVKIESGRKVKEVEVKTGEEVKAGQLLFEYDLSSIEDDLKQAQLDLDRLKNEQISLTEQIATLEAEKKKAKAEDQLSYTIEIETNKMNLKKNEYSQKSKQSEIDKLQSATQNTEVRSEIDGVIQKIDTSKMTSDDGDSVDDSSAMDSSMSSGDGSSDSSAFITILSTGAYRVKGKVNEQNRDSIVPGEAVIIRSRVDSSKTWKGTMGSVDVNNGTSDDSSNDMYMGMASTSSDDQTTSTSYPFYVELDSSENLMLGQHVYIERDIGQDEKKDGLWLSDYYILDTDTNEPYVWAASDKNRLEKRYVTLGEHDDDLGEYKIVEGLTKKDAIAFPTAALEEGEKTEIGDLAQTMSGGADGITDMDADHGNMDDEQPDSADGEAYTDPDMEEGSEDDSSDDSIDPNEELVPIDEAPGMSAGEDVEGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EFG9</accession>
    <name>A0A174EFG9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulatory protein BlaR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">blaR1_4</name>
        <name evidence="5" type="ORF">ERS852478_02556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200785.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35316">
        <property type="protein sequence ID" value="CUO35316"/>
        <property type="gene ID" value="ERS852478_02556"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2602">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="4">
        <location>
            <begin position="10"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="391"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO35316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="598" mass="68384" checksum="9C51C2E9FECB4A49" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EK61</accession>
    <name>A0A174EK61_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ktr system potassium uptake protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ktrA_2</name>
        <name evidence="4" type="ORF">BWLFYP14_00910</name>
        <name evidence="3" type="ORF">ERS852478_02647</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707798.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38352">
        <property type="protein sequence ID" value="CUO38352"/>
        <property type="gene ID" value="ERS852478_02647"/>
    </dbReference>
    <dbReference type="GeneID" id="66492690"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="137"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO38352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX63432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="217" mass="23656" checksum="F4F98E4BA5B9995B" modified="2016-09-07" version="1">MKNKSYAVIGLGQFGMTVALTLAEANCDVLAIDDKDDNVQDIAEKVSYAVKADVRDPGILESFGVQNVDVAVIAVAENMEASITATMQVKELGVPFVMAKAMNSLHGRILEKIGADKVIYPEHSMGIRVARNLLSSGFVDMFELSSDFSMAEFKIPREWIGKTLRELKVREKYNINLIGLKHGDKMNMNVAPDEVFPADCTVVAAGANSDLNKVSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ELU5</accession>
    <name>A0A174ELU5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase J</fullName>
            <ecNumber evidence="1">2.1.1.242</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA m2G1516 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (guanine-N(2)-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">rsmJ</name>
        <name evidence="5" type="ORF">BWLFYP14_01456</name>
        <name evidence="2" type="ORF">ERS852478_02621</name>
        <name evidence="4" type="ORF">GT712_07470</name>
        <name evidence="3" type="ORF">GT728_02870</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the guanosine in position 1516 of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(1516) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43220"/>
            <dbReference type="Rhea" id="RHEA-COMP:10412"/>
            <dbReference type="Rhea" id="RHEA-COMP:10413"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
            <dbReference type="EC" id="2.1.1.242"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.242" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO37195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000011">
        <property type="protein sequence ID" value="MZS88910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000033">
        <property type="protein sequence ID" value="VUX64602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703940.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37195">
        <property type="protein sequence ID" value="CUO37195"/>
        <property type="gene ID" value="ERS852478_02621"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008990">
        <property type="term" value="F:rRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01523">
        <property type="entry name" value="16SrRNA_methyltr_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007536">
        <property type="entry name" value="16SrRNA_methylTrfase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36112">
        <property type="entry name" value="PTHR36112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04445">
        <property type="entry name" value="SAM_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO37195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="243" mass="27136" checksum="4F886EC619F7939F" modified="2016-09-07" version="1">MNDKITVCLGKGGQREMAESFARKNNVPIMDKPGEHLTVMFDSRGVSLTGYGLTYQGDFEGMLHRVTNGRLSHEMLVRAVKTEGEHLKAIDATAGMGEDGFLLAAYGYEVTLYEQNPVIAALLKDALRRARKHPVLKDIASRMKLVEGDSVSCMEKLMDPVDVIYLDPMFPKRQKSGLINKKLQLIQKLEPPCSEEKDLFDAAIKAGPSRIIVKRPLKSVCLDGREPSYILKGKAIRYDCYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ENB8</accession>
    <name>A0A174ENB8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutathione transport system permease protein gsiD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gsiD_3</name>
        <name evidence="7" type="ORF">ERS852478_02633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO37959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707779.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37959">
        <property type="protein sequence ID" value="CUO37959"/>
        <property type="gene ID" value="ERS852478_02633"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO37959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="295" mass="32839" checksum="58F68F06F0339E76" modified="2016-09-07" version="1">MTNHLFELAGNRKTETVIPKSKKKWYQGKPVVSAAILILIVLGCLCAELIMTKDPAYMDLLNYNKAPDREFLFGTDTMGRDIFSMIWYGGRISILIGGLATVISTFIAVVVGAFSGVAPAWLDELIMRFTEIFLSIPTLLLIILLQAIMGDANILSLSFVIGVTSWTSIAKVVRTEVRQIRNSEYIIAARCMGAGFFRILWKHLVPNFFSSIMFMVVMNVRTAMISEATLSFMGIGLPIEVITWGSMLSLSDKALMTGSWWIILIPGLFLITTVLCLTNIGNACRERTNRKESNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ERF4</accession>
    <name>A0A174ERF4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Sporulation initiation inhibitor protein soj</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">soj_5</name>
        <name evidence="3" type="synonym">soj_3</name>
        <name evidence="2" type="ORF">ERS852478_02674</name>
        <name evidence="3" type="ORF">ERS852523_02275</name>
        <name evidence="4" type="ORF">GT728_17870</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO39208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000023">
        <property type="protein sequence ID" value="CUP63644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000063">
        <property type="protein sequence ID" value="MZL34990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379873.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000063.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000115_gene2449"/>
    <dbReference type="EnsemblBacteria" id="CUO39208">
        <property type="protein sequence ID" value="CUO39208"/>
        <property type="gene ID" value="ERS852478_02674"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP63644">
        <property type="protein sequence ID" value="CUP63644"/>
        <property type="gene ID" value="ERS852523_02275"/>
    </dbReference>
    <dbReference type="GeneID" id="66492662"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="6"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO39208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP63644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="262" mass="29590" checksum="CD79029253FFAACE" modified="2016-09-07" version="1">MGKTITICFTNNKGGSGKTTTCSNLGAAMAQAGKKVLLIDGDMQLNLSLAFFPENWVLEQAKGEKNLYCAIGKQEELSGYVVHTPYENLDLIPSSTLMSSIEYELFTKWQREFILRKCIQKIKDAGNYDYILIDAPPTLGGWVMNILCASDRVIIPVEASPWGMFGLANMFEFLNEVKQITPELEVAGIAVTKVDTRKSYYKQTMETLHELEDIHVFEQIIRVDSSVEWSQDNSIPVVEYKKSSRSAREYTRLAEEVMELCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F052</accession>
    <name>A0A174F052_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7 11">Ribose transport system permease protein RbsC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rbsC_6</name>
        <name evidence="11" type="synonym">rbsC_1</name>
        <name evidence="11" type="ORF">BWLFYP14_01037</name>
        <name evidence="7" type="ORF">ERS852478_02810</name>
        <name evidence="8" type="ORF">ERS852523_03636</name>
        <name evidence="10" type="ORF">GT712_17360</name>
        <name evidence="9" type="ORF">GT728_08510</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000058">
        <property type="protein sequence ID" value="CUQ01892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000016">
        <property type="protein sequence ID" value="MZL33236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000050">
        <property type="protein sequence ID" value="MZS90775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058631.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43593">
        <property type="protein sequence ID" value="CUO43593"/>
        <property type="gene ID" value="ERS852478_02810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ01892">
        <property type="protein sequence ID" value="CUQ01892"/>
        <property type="gene ID" value="ERS852523_03636"/>
    </dbReference>
    <dbReference type="GeneID" id="66494717"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="287"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO43593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
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            <dbReference type="EMBL" id="CUQ01892.1"/>
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    </evidence>
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    <evidence type="ECO:0000313" key="11">
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            <dbReference type="EMBL" id="VUX63662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
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            <dbReference type="Proteomes" id="UP000366766"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="319" mass="34298" checksum="0F780D980B95AD73" modified="2016-09-07" version="1">MSTTKKSTEQVPFLERPIVRTILPIAGFVIICVLFAILTDGRLFQPKNISLLLSQSYMLLISSIGVFMVMTMGGLDFSQGSMLGVASIVVCYLSHYNMVLAALGGVVTGGLIGLINGYFNVKRKITSFIVTICTMYLFRGVCAYATTNSPVYAVSDISKYNTLPFMLTFTVIIFVVAYLVFTYTGLGSRLKAIGAGETAARFAGIRVETTKILVFVAAGCITGLAAFVNAIKVGSVTSTAGNQLETQIMIALVLGGMPVNGGAKVRFYNIILGVMTYKVLSSGLVMLMMPTQLQQLILGIIFLIEVAIFSDRKTGMIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F7F2</accession>
    <name>A0A174F7F2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase and inactivated derivatives</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">ERS852478_02890</name>
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    <organism evidence="3 4">
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    <reference evidence="3 4" key="1">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <property type="entry name" value="RNaseH_sf"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="INTEGRASE"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH IS408-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="131"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO46302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="512" mass="58900" checksum="E9FE6D79D91688A1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FK94</accession>
    <name>A0A174FK94_9FIRM</name>
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        <submittedName>
            <fullName evidence="5">Protein involved in cell division</fullName>
        </submittedName>
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        <name evidence="5" type="ORF">ERS852478_02991</name>
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        <name type="scientific">Blautia wexlerae</name>
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            <strain evidence="5 6">2789STDY5834863</strain>
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    <dbReference type="EnsemblBacteria" id="CUO49368">
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        <property type="entry name" value="Fido-like_dom_sf"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="4">
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            <end position="193"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="134"/>
            <end position="141"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="171"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for autoinhibition of adenylyltransferase activity" evidence="3">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO49368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="279" mass="32819" checksum="109EA1504BDDAC0F" modified="2016-09-07" version="1">MSQIEANSLSLGQVRDVINGRLVLGEQKEIQEVKNAYAAYESLSEINPYSIKDLKKFHGIMTKYLVEECGEFRHGEEGVFNGDECIFMAPPAQFVPQLMDELFEWMKKSRNSVHPLIMSSVFHYEFVFIHPFADGNGRMARLWHTAILSKWKHVFEFIPIESQIEKFQDEYYDAIVRCHVSGESTIFIEFMLSQIDRILEDISLQMNEENEQFSETVRKMLEIMEYDTPYTRKTLMEKLGLKSRDGFRRNYLQPALEMNLIQMTLPDKPNSRNQRYIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FKZ6</accession>
    <name>A0A174FKZ6_9FIRM</name>
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        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase</fullName>
        </submittedName>
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            <taxon>Clostridia</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO49120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201049.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49120">
        <property type="protein sequence ID" value="CUO49120"/>
        <property type="gene ID" value="ERS852478_02982"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="5"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO49120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="362" mass="39832" checksum="3B8CD0385BDF3F7E" modified="2016-09-07" version="1">MDLSTLVKMSNTYGSNPAYVLAGGGNTSVKDDTTLYVKGSGTQLATIKAEEFVEMSRARLNEIMKTDYPEDDVKRESLYLADVMAAVTDADKTKRPSVEALLHNLFAYTYVLHVHPTLVNGLTCGKGAKELSEQLLGKDVLWIDICKPGYTLARICYEKMNAYKEEYGKDVQVLLLQNHGIFVAANTVEEIGALFDGVISKLEKQVKRTADVSDAVTSEKEQAAEKLSRLLGHAVEVVPVAEADHFVKDKAAAAPLLKPFTPDHIVYCGPYPLFVEDIDQAKAALDAFMAENDKEPRLILVQGVGAFIMEDDKGKAAKAQLLVKDAIKLAVYAESFGGPLHMTDDITYFITHWEAEAYRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FML7</accession>
    <name>A0A174FML7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit b</fullName>
            <shortName evidence="11">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">atpF_2</name>
        <name evidence="11 16" type="synonym">atpF</name>
        <name evidence="17" type="ORF">BWLFYP14_03549</name>
        <name evidence="14" type="ORF">ERS852478_03034</name>
        <name evidence="15" type="ORF">ERS852523_01442</name>
        <name evidence="16" type="ORF">GT712_01550</name>
    </gene>
    <organism evidence="14 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">2789STDY5834863</strain>
            <strain evidence="15 19">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="16 21" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 21">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="17 20" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="10 11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP38452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704967.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000037_gene3259"/>
    <dbReference type="EnsemblBacteria" id="CUO50767">
        <property type="protein sequence ID" value="CUO50767"/>
        <property type="gene ID" value="ERS852478_03034"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP38452">
        <property type="protein sequence ID" value="CUP38452"/>
        <property type="gene ID" value="ERS852523_01442"/>
    </dbReference>
    <dbReference type="GeneID" id="66495472"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="37"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO50767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUP38452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZS87809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VUX67274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="167" mass="18830" checksum="2E9B008CFA82BDB9" modified="2016-09-07" version="1">MQVQELVGIVPWNFIATICNLFIQVYLIKRFLFKPINEMLEKRKAKADAQIQDAVKAKEEAQAMKAEYEKNMQEAKNRANDIVMTAQKTAAIQSEEMLKEASSQVTAMKEKAEKDIAQEKRKAVNEIKGEIGGMAVEIAGKVIEREISEEDHAKLIDEFIENVGEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FNC2</accession>
    <name>A0A174FNC2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized N-acetyltransferase YvbK</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yvbK</name>
        <name evidence="2" type="ORF">ERS852478_03042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO51017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201095.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51017">
        <property type="protein sequence ID" value="CUO51017"/>
        <property type="gene ID" value="ERS852478_03042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO51017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="144" mass="16425" checksum="6BA12F93DB19FC33" modified="2016-09-07" version="1">MKIREVNENKKQFIALLLLADEQENMIDHYLEKGTMYVLEDGNVKAECVVTDEDNGILEIKNIAVDPQNQGQGYGKALIDFLVSKYADEYSILQVGTGDSPLTVPFYEKCGFVRSHNIPNFFTDNYDHPIYECGVQFTSLQLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FP39</accession>
    <name>A0A174FP39_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ribosomal RNA large subunit methyltransferase K</fullName>
            <ecNumber evidence="9">2.1.1.264</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Ribosomal RNA large subunit methyltransferase L</fullName>
            <ecNumber evidence="5">2.1.1.173</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="7">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rlmL_2</name>
        <name evidence="9" type="synonym">rlmK</name>
        <name evidence="9" type="ORF">BWLFYP14_03530</name>
        <name evidence="5" type="ORF">ERS852478_03015</name>
        <name evidence="6" type="ORF">ERS852523_03219</name>
        <name evidence="8" type="ORF">GT712_01455</name>
        <name evidence="7" type="ORF">GT728_10140</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.264" evidence="9"/>
    <dbReference type="EC" id="2.1.1.173" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000042">
        <property type="protein sequence ID" value="CUP90509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000021">
        <property type="protein sequence ID" value="MZL33548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705027.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000010_gene2797"/>
    <dbReference type="EnsemblBacteria" id="CUO50270">
        <property type="protein sequence ID" value="CUO50270"/>
        <property type="gene ID" value="ERS852478_03015"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP90509">
        <property type="protein sequence ID" value="CUP90509"/>
        <property type="gene ID" value="ERS852523_03219"/>
    </dbReference>
    <dbReference type="GeneID" id="66495453"/>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052915">
        <property type="term" value="F:23S rRNA (guanine(2445)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltrans_SAM" evidence="4">
        <location>
            <begin position="55"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO50270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP90509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS87790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX67255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="285" mass="31957" checksum="71ABD77370D4AB79" modified="2016-09-07" version="1">MWIADGWKDYEVIDTSCGEKLERWGDYLLVRPDPQVIWDTPKVNKGWKHMNGHYHRSKKGGGEWEFFDLPEQWDIHYKGLTFNLKPFSFKHTGLFPEQAVNWDWFGNKIRNAGRPVKVLNLFAYTGGATLAAAAAGASVTHVDASKGMVTWAKENAVASGLGDAPIRWLVDDCVKFVEREIRRGNHYDAIIMDPPSYGRGPKGEIWKIEDCIHDLIKLCTKILSDEPLFFLINSYTTGLAPAVLTYMLSTELKKFGGHVDSQEIGLPVSSNGLVLPCGASGRWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FQ33</accession>
    <name>A0A174FQ33_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO52372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201113.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52372">
        <property type="protein sequence ID" value="CUO52372"/>
        <property type="gene ID" value="ERS852478_03078"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO52372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="313" mass="37126" checksum="9B87DF433FCD2C4A" modified="2016-09-07" version="1">MNLGSINENDFKESKAVAIAKNIIEENRCFKTFFCEMDKRPNLDGHMSFIYKNQERMIIEVQIKTLPQNYCLSKSRVSKYYYDCDTKVFNVVKENVSLNPVSLILVDTYNKKVFCILLTRQYVAELHVNGKTTKRIYFNDSDEFNNDKFITELLKYNKILNTNTSCHVKVRTIYNILKPRRKLPHIELEHIYDVENYGLVYTHNNILGYLGNFWVNTKGKKYHIYSLYMQDTAYDNSFNQYEYIRLESEKTHIFAYRQSSGTSITDADIVNILYEIAYFKKKDIVFYSSGIPVYVIAGRVIWRLRAEKIEKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FWI0</accession>
    <name>A0A174FWI0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4366 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_03098</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201154.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53186">
        <property type="protein sequence ID" value="CUO53186"/>
        <property type="gene ID" value="ERS852478_03098"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z81G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025376">
        <property type="entry name" value="DUF4366"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14283">
        <property type="entry name" value="DUF4366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022031" description="DUF4366 domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4366" evidence="4">
        <location>
            <begin position="55"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO53186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="241" mass="25881" checksum="BC4DEAAB9DBBC86D" modified="2016-09-07" version="1">MKNKLKKTMTALCAALILMGGFSVPAYAQGTAAEPPAEDATNDSNVVVEEEETPPLTPKGNATLVDDFGGNKQLITVTTKSGNYFYILIDRAAEGEQTVHFLNQVDEADLMALTETGEATKKPEVCNCTEKCEAGKVNTSCPVCATTLTGCTGKEPTPTPTEQPEEPKEKGGNPGAVLALVLFVLLGGGAAFYYFKFVKPKQNVKGSTDLEDFDFEDYDEDEPEADTGEVSKEEETEDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FY62</accession>
    <name>A0A174FY62_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF3801)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201171.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53858">
        <property type="protein sequence ID" value="CUO53858"/>
        <property type="gene ID" value="ERS852478_03122"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBU5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024234">
        <property type="entry name" value="DUF3801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12687">
        <property type="entry name" value="DUF3801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO53858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="160" mass="18147" checksum="3A169ED2A91EA52F" modified="2016-09-07" version="1">MQEEANEKTIALYIKTGKLTAQQLQKAMKALLAQMKKQHDKQKIPHGKQTLKQLMKQNADVSNIEITKDNIKAFESTAKKYGIDFALKKDSTETPPRYLVFFKGRDADALTAAFKEFSAKKLTQEQKPSIRKLIVSLKEKAAALNAQREKVKNKDRGIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FY91</accession>
    <name>A0A174FY91_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">truA</name>
        <name evidence="10" type="ORF">BWLFYP14_00867</name>
        <name evidence="9" type="ORF">ERS852478_03165</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000024">
        <property type="protein sequence ID" value="VUX63389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705977.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55193">
        <property type="protein sequence ID" value="CUO55193"/>
        <property type="gene ID" value="ERS852478_03165"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="7"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="143"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO55193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX63389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="246" mass="27578" checksum="3237784D066FFE90" modified="2016-09-07" version="1">MKRIGLVVAYDGTNYCGWQTQPNGITVQGVLNDTLSELLGEKIETIGASRTDAGVHAMGNVAVFDTNTRIPGEKISYALNQRLPEDIRIQLSEEVEPDFHPRYCDSEKTYEYRILNRKFPVPTERLYTYFYHYKLDVDKMKAATSYLIGQHDFASFCGAKAQVKTTIRTVTGIDVWRDGDIVTIRVTGTGFLYNMVRIISGTLIEVGNGQYPPERVKTILEACNREMAGPTAPAQGLTLMGIEFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G7R4</accession>
    <name>A0A174G7R4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO58474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58474">
        <property type="protein sequence ID" value="CUO58474"/>
        <property type="gene ID" value="ERS852478_03255"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZT35">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="46" mass="5511" checksum="5C5607F5B3B70FA9" modified="2016-09-07" version="1">MMFMSIPFIAGMIIDIWYIGIGCLMAWVIWFVMFILLLMDRHKREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G9R1</accession>
    <name>A0A174G9R1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="2 4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">trpF</name>
        <name evidence="6" type="ORF">ERS852478_03229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="2 4"/>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201244.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57640">
        <property type="protein sequence ID" value="CUO57640"/>
        <property type="gene ID" value="ERS852478_03229"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="12"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO57640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="208" mass="23108" checksum="85F41E5879634329" modified="2016-09-07" version="1">MTREQQQRTKIKICGLKRPEDITYVNEAKPDYCGFIIEFPKSSRNVTGALVRELTAKLNPDIIPVGVFVNVAPERVEELLLDGTIHIAQLHGQEDEAYIRRIQKNTGHQVIKAFSVKTAQDIEKALKSPADYILLDQGGGGTGQTFDWSLIPEIDRPFFLAGGLGADNLETAVRTIHPYAVDLSSSVETDGMKDRDKILKAVQLVHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GST7</accession>
    <name>A0A174GST7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trxA_5</name>
        <name evidence="8" type="synonym">trxA</name>
        <name evidence="10" type="synonym">trxA_4</name>
        <name evidence="10" type="ORF">BWLFYP14_02354</name>
        <name evidence="7" type="ORF">ERS852478_03484</name>
        <name evidence="9" type="ORF">GT712_16505</name>
        <name evidence="8" type="ORF">GT728_16030</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">BIOML-A1</strain>
            <strain evidence="9 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005421612.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65772">
        <property type="protein sequence ID" value="CUO65772"/>
        <property type="gene ID" value="ERS852478_03484"/>
    </dbReference>
    <dbReference type="GeneID" id="61851063"/>
    <dbReference type="GeneID" id="67479303"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO65772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL34661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS90617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX65984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="101" mass="11339" checksum="F4B4A7BBE16AB2CD" modified="2016-09-07" version="1">MSAININKNNFQNEVLNSDKPVLLDFWASWCAPCRMVVPIVEEIASERRDIKVGKINVDEEPELANKFSIMSIPTLVVMKNGKIVQQVSGARPKNAILEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GT74</accession>
    <name>A0A174GT74_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-glucose 6-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_02278</name>
        <name evidence="1" type="ORF">ERS852478_03444</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64467">
        <property type="protein sequence ID" value="CUO64467"/>
        <property type="gene ID" value="ERS852478_03444"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO64467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX65913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="36" mass="4128" checksum="034383A9330BEE16" modified="2016-09-07" version="1">MTRIQYNLDEVMVIKSTIPVGFTASVRAKYHCDNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GXX4</accession>
    <name>A0A174GXX4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Daunorubicin/doxorubicin resistance ATP-binding protein DrrA</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">drrA_3</name>
        <name evidence="5" type="ORF">ERS852478_03539</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201422.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67474">
        <property type="protein sequence ID" value="CUO67474"/>
        <property type="gene ID" value="ERS852478_03539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO67474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="290" mass="32330" checksum="E36CA135129B04DF" modified="2016-09-07" version="1">MSIRINDLTVRFKNGVVAVNKASLEIPKGIYGLLGENGAGKTTLMRVLTTVLKQTEGMVSLDGILYNEGNYEKIQKKIGYLPQEIDLYPNLTVKECLVYMGGLSGVSTNDLKQRITYYLEKTSLTEQQNKKMRQLSGGMKRRVGLIQALLNNPDFLIIDEPTTGLDPEERIRIRNLLVDFSKDRTVLFSTHVVEDLAATCTQLAIMKKGSFLYSGSVSGLLENAKGCVWNCTVQNAEEARLLEANYSISSKQYVENGIHMKVLSKGKPNEKCVPDNDITLEDAYIYLTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZH4</accession>
    <name>A0A174GZH4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PD-(D/E)XK nuclease family transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201420.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67391">
        <property type="protein sequence ID" value="CUO67391"/>
        <property type="gene ID" value="ERS852478_03536"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO67391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="265" mass="30710" checksum="15A442B3544D7AB9" modified="2016-09-07" version="1">MDNTEETLDFEQKHKEDLQRLRGFRLLDDDFMSKVFEDKACAEFLLQIILQRHDLKVQSVQGQYDIKNLQGRSIRLDILAVDSNNRIYNIEIQRSDLGADAKRARYNSSLIDANITEAGDKYDALTETYVIFITENDVLKAGLPIYHVDRIIQETGEPFGDEAHIIYINSQIKDETELGKLMHDFSCTNPKDMYYKILADRVRYFKEDEEGVLTMCREMENMRKAERIEIAKRMLASGKLTYEDIAAFTDLTLEEIEALAVQKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H0B4</accession>
    <name>A0A174H0B4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_03568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060682.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68324">
        <property type="protein sequence ID" value="CUO68324"/>
        <property type="gene ID" value="ERS852478_03568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011639">
        <property type="entry name" value="RM_methylase_Eco57I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07669">
        <property type="entry name" value="Eco57I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eco57I" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO68324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="335" mass="38278" checksum="A77DA8D7DD6FBD9E" modified="2016-09-07" version="1">MKFDFVIGNPPYQEDTDGAGRQAKPVYNLFFEEAKKIEPESISLITPSRWFSGGMGLNQFREDMMNDRSLKVICDYTNAKDCFPDNSISGGVNCFVWKKDYKGDCRFINTTNGVTTELERPLNEFPVLVRYNQAITIIHKVQSKSKKSIADITSGLMPFGLSTSYRGRKVKSKKDNLTLYASNCVTYISESEIDKGYEYLDKYKVLVSKTGAEHAGEPSRDGKFRVIPSSMKVIEPNEVCTHSYFLVGATSNKKVAEHICKYMKTKFVRFLMLMAMSGFGLSKNVLLFVPIQKFDDDSDIDWTKNISEIDELLYKKYNFDPKDINFIENNVKEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H0J1</accession>
    <name>A0A174H0J1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposon Tn1000 resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tnpR_3</name>
        <name evidence="4" type="ORF">ERS852478_03552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201425.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67781">
        <property type="protein sequence ID" value="CUO67781"/>
        <property type="gene ID" value="ERS852478_03552"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="7"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="163"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="402"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO67781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="648" mass="74269" checksum="EC8BE4FCDF956C90" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H3H8</accession>
    <name>A0A174H3H8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67375">
        <property type="protein sequence ID" value="CUO67375"/>
        <property type="gene ID" value="ERS852478_03535"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO67375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="261" mass="30284" checksum="28DA178B91268B53" modified="2016-09-07" version="1">MGGVIHPLHQVDLLTPAERKITEKEYWAQRRGQEKLDELNQKMKEDGITPKETRYQTEKQFLRDAIDDAASTAQSPEEFSKILDEKYHIIFKISRNRYSYLHPGRKKYITERNLGTRYTEDFLLKAFEENTKSHREQKEEILEQQSPNTSTDLPTVPFSDTSAISTPFIFIKSDLRLVIDLQTCIKAQQSGAYAQKVKLTNLKQMAQTVAYIQEHGYDSLDDFHVELNQASDQTSAPRKSLKDTEQQLKDVNEQIEKVKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HDQ1</accession>
    <name>A0A174HDQ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CHAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03725</name>
        <name evidence="5" type="ORF">GT712_18510</name>
        <name evidence="4" type="ORF">GT728_02350</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A1</strain>
            <strain evidence="5 7">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000045">
        <property type="protein sequence ID" value="CUO73023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000061">
        <property type="protein sequence ID" value="MZS90982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703824.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73023">
        <property type="protein sequence ID" value="CUO73023"/>
        <property type="gene ID" value="ERS852478_03725"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="281"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO73023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="396" mass="43001" checksum="F6BECF7C141D3DAE" modified="2016-09-07" version="1">MDSIITVKTAQRAAQAARAAAKAAVVTVKAIAKATALAIKAIIAGTKALIAAIAAGGWVAVLVIIVICLIGMILGSVFGIFFSDEDSGTGMSMQTVVQEINTEYDTKLQEEKNSVSYDVLEMSGSRAVWKEVLAVYSVKTNTDQDNPQEVATMDDGKKQLLKDIFWEMNQISSRTESKTETVITETDDGHGNIVETESTVTQTYLYITVSHKTAEEMAAQYGFNEEQKGYLAELLADENNYLWSQVLYGITGGDGQIVTVALSLVGNVGGQPYWSWYGFNSRVEWCACFVSWCANECGYIDAGVIPKYAGCVNGVQWFKDRGQWLDGSAEPAPGMIIFFDWADESGQDGLSDHTGIVQKVENGKVYTVEGNSGDSCRVNEYSIGYYEILGYGAPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HGH8</accession>
    <name>A0A174HGH8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted permeases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_03760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000047">
        <property type="protein sequence ID" value="CUO73974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201513.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73974">
        <property type="protein sequence ID" value="CUO73974"/>
        <property type="gene ID" value="ERS852478_03760"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="151"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO73974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="291" mass="31733" checksum="DD26D9763EA92CF9" modified="2016-09-07" version="1">MKQENYIKGMIMIILSAFFFACMNVSVRLAGDLPSVEKSFFRNLVAAVFAAVILCKNRTVPKVDKKYWGPLILRCVCGTLGILCNFYAIDHLLVADASILNKLSPFFAIIFSFLLLKEKIRPAQAACVALAFIGCLFVVKPGFQNAALVPALIGVCGGLGAGIAYTMVRVLGTHGVKGPVIVFYFSFFSCLSVVPWMLFHFTPMSMKQLVTLLMAGLFAAGGQFTITAAYTYAPAGKISIFDYSQIIFATMLGFILFGEIPDKYSFTGYVLIILASLGTFLYNMRVAKAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HGZ6</accession>
    <name>A0A174HGZ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replication initiator protein A (RepA) N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO72175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994024.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000100.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72175">
        <property type="protein sequence ID" value="CUO72175"/>
        <property type="gene ID" value="ERS852478_03698"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010724">
        <property type="entry name" value="RepA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06970">
        <property type="entry name" value="RepA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RepA_N" evidence="1">
        <location>
            <begin position="3"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="73" mass="8812" checksum="3B8333B28BF9271F" modified="2016-09-07" version="1">MLQYFQFPKFLLKLRISQTAKFLYMILYDRARISRKNSWIDKYGNVAPSKVTEKYKSNKYHEVNYCYGEGESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HKJ6</accession>
    <name>A0A174HKJ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000051">
        <property type="protein sequence ID" value="CUO75414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75414">
        <property type="protein sequence ID" value="CUO75414"/>
        <property type="gene ID" value="ERS852478_03804"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO75414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="76" mass="8797" checksum="BE74E109C1625863" modified="2016-09-07" version="1">MGGEVLELKTDKLINEIRQDVKEEVKAEVKEEVKTETKEKIVICMLKRGKSTLEEIAADTQMPIEQVERIKKEQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HM48</accession>
    <name>A0A174HM48_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000047">
        <property type="protein sequence ID" value="CUO73965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201512.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73965">
        <property type="protein sequence ID" value="CUO73965"/>
        <property type="gene ID" value="ERS852478_03758"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012652">
        <property type="entry name" value="ThiW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09512">
        <property type="entry name" value="ThiW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024534">
        <property type="entry name" value="ThiW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02359">
        <property type="entry name" value="thiW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO73965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="195" mass="20986" checksum="5814C168725059AF" modified="2016-09-07" version="1">MNTDRSKTLRMVMLAMMVAIGVVISPILRIEGMCPTAHLINIVCSVLLGPWYSLLCATLIGIIRMMFMGIPPLALTGAVFGAFLSGVFYRASHGKIICAVIGEIFGTGIIGSLVSYPVMAFLMGRSGLNAFFYTPMFLAATCMGGTIAYFFLKALSHAGMLAKFQQSLGAKVYDRKSDKSQTIDPSSQTADSLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JEL2</accession>
    <name>A0A174JEL2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn(II)-responsive regulator of zntA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">zntR</name>
        <name evidence="2" type="synonym">zntR_1</name>
        <name evidence="2" type="ORF">ERS852478_01989</name>
        <name evidence="3" type="ORF">ERS852523_00094</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO96656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707529.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2259"/>
    <dbReference type="EnsemblBacteria" id="CUO15393">
        <property type="protein sequence ID" value="CUO15393"/>
        <property type="gene ID" value="ERS852478_01989"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96656">
        <property type="protein sequence ID" value="CUO96656"/>
        <property type="gene ID" value="ERS852523_00094"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO15393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO96656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="393" mass="45542" checksum="4F77E2F813C3867E" modified="2016-09-07" version="1">MKKDGYYSSGEFARMAHVTLRTIRYYDKQNILKPSYVTESGARFYTDEDFARLSQILLLKYLGFSLDDIREMTIDDSDYHFMENSLNIQLKLVRDRIEQMQLVEKAIQDTTDAIRSHHAIDWNQMLDLIHLTGMEKSMKNQYQNASNISSRINLHSLYSQNKQGWFPWVYEQCQIHPGMRILELGCGDGVLWTQNISSLPGKVSVTLSDLSSGMLRDARRAIGRKDSRFSFEAFDCARIPHEDRSFDLVIANHVLFYCEDISAVCSEIQRVLTPGGKLICSTYGKKHMQEVSRLVRDFDDRIVLSADKLYERFGRENGADILAPYFSRIFWESYKDSLLVPDAEPLISYILSCHGNQNQYLLDKYKDFRGFVSRKTKDGFFITKDAGIFLCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JIJ9</accession>
    <name>A0A174JIJ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">pyrG</name>
        <name evidence="16" type="ORF">BWLFYP14_00751</name>
        <name evidence="12" type="ORF">ERS852478_03315</name>
        <name evidence="13" type="ORF">ERS852523_00131</name>
        <name evidence="15" type="ORF">GT712_14920</name>
        <name evidence="14" type="ORF">GT728_14640</name>
    </gene>
    <organism evidence="13 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 17">2789STDY5834863</strain>
            <strain evidence="13 18">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="14 20 21" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 21">BIOML-A1</strain>
            <strain evidence="15 20">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="16 19" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO97697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000039">
        <property type="protein sequence ID" value="MZL34401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000034">
        <property type="protein sequence ID" value="MZS90325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000019">
        <property type="protein sequence ID" value="VUX63002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704921.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000041_gene2585"/>
    <dbReference type="EnsemblBacteria" id="CUO60330">
        <property type="protein sequence ID" value="CUO60330"/>
        <property type="gene ID" value="ERS852478_03315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97697">
        <property type="protein sequence ID" value="CUO97697"/>
        <property type="gene ID" value="ERS852523_00131"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="303"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="383"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO60330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO97697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZL34401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZS90325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VUX63002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="541" mass="60634" checksum="B786B4968E9B1CE6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K736</accession>
    <name>A0A174K736_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF218 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_03121</name>
        <name evidence="2" type="ORF">ERS852478_01112</name>
        <name evidence="3" type="ORF">ERS852523_00434</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CUN80595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUP06631.1"/>
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    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUN80595"/>
        <property type="gene ID" value="ERS852478_01112"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06631">
        <property type="protein sequence ID" value="CUP06631"/>
        <property type="gene ID" value="ERS852523_00434"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN80595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP06631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="177" mass="19966" checksum="868FF907C70F3E27" modified="2016-09-07" version="1">MILVLAEAARNINIAAVRMRKHPNLEYIIVLGAHVEGTRLTKALLERTRRALQYMEENPETKAVLSGGKGDGESITEAQAMCNYLVEHGIDRERLILEEKSTSTTENLKFSLGMIGLNHSVGIVTNNFHVFRGTAIGKKCGCREIYPIPSRYRSWRLLIYIPREILAIIKDKLMGNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L380</accession>
    <name>A0A174L380_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Diadenosine hexaphosphate hydrolase</fullName>
            <ecNumber evidence="8">3.6.1.61</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="6">NUDIX domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Putative 8-oxo-dGTP diphosphatase YtkD</fullName>
            <ecNumber evidence="5">3.6.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ytkD</name>
        <name evidence="8" type="synonym">ndx1</name>
        <name evidence="8" type="ORF">BWLFYP14_00976</name>
        <name evidence="4" type="ORF">ERS852478_01502</name>
        <name evidence="5" type="ORF">ERS852523_00777</name>
        <name evidence="7" type="ORF">GT712_13040</name>
        <name evidence="6" type="ORF">GT728_11015</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">2789STDY5834863</strain>
            <strain evidence="5 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 13">BIOML-A1</strain>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.61" evidence="8"/>
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    <dbReference type="EMBL" id="CYZN01000008">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUN96284"/>
        <property type="gene ID" value="ERS852478_01502"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17146">
        <property type="protein sequence ID" value="CUP17146"/>
        <property type="gene ID" value="ERS852523_00777"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="NUDIX_hydrolase_CS"/>
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        <property type="entry name" value="NUDIX_hydrolase_dom"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CUN96284.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUP17146.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="151" mass="17987" checksum="D9ECB037C0813321" modified="2016-09-07" version="1">MIEATSCGGVVIHRGKILTLYKSYRNRYEGWVLPKGTVEPGETHEQTALREVMEEAGVRATIVKYIGKSQYNFTVPEDVVFKEVHWYLMTADNYHSKPQREEFFVDSGYYKFHEIYHLLRFSNEKQIVERAYQEYLEMRSNGLWGKQHKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
        <submittedName>
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        <submittedName>
            <fullName evidence="5">Folate transporter FolT</fullName>
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    <gene>
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        <name evidence="5" type="ORF">BWLFYP14_01293</name>
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    <reference evidence="3 6 7" key="1">
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            <authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000054_gene1899"/>
    <dbReference type="EnsemblBacteria" id="CUN73188">
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ECF_S_folate_fam"/>
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        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
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    </dbReference>
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            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
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            <end position="62"/>
        </location>
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        </location>
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        </location>
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        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUP28485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL31865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="186" mass="19874" checksum="93E9E6BD7E8CAE54" modified="2016-09-07" version="1">MQKKQYWNVKTLVFMALLIAMHLVLTRVLVIDLGAYRISVGSVCTILAGLWLGPVAGGVCGLCADIIGCFMKGYAVNPFITVAAILWGVLPALAKPLFANRKKTGKTVGICVSIVVTAVLSSLVLTTAGLVIMLGYNFYAIMPGRLVQFAIMIPIYCVLTCLLYFSPLTAMVVGNTSPAVLKNKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MYJ9</accession>
    <name>A0A174MYJ9_9FIRM</name>
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        <submittedName>
            <fullName evidence="8">Dipeptide ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Glutathione import ATP-binding protein GsiA</fullName>
            <ecNumber evidence="7">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
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        <name evidence="6" type="synonym">gsiA_10</name>
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        <name evidence="8" type="ORF">GT712_01870</name>
    </gene>
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        <name type="scientific">Blautia wexlerae</name>
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            <taxon>Eubacteriales</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">2789STDY5834863</strain>
            <strain evidence="7 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
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                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP40131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000028_gene212"/>
    <dbReference type="EnsemblBacteria" id="CUO48106">
        <property type="protein sequence ID" value="CUO48106"/>
        <property type="gene ID" value="ERS852478_02951"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP40131">
        <property type="protein sequence ID" value="CUP40131"/>
        <property type="gene ID" value="ERS852523_01500"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO48106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP40131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS87871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="324" mass="36032" checksum="AE035C2D6DE6B1C6" modified="2016-09-07" version="1">MSEPLLSVKNMKKTFQANGGMFSKKKFVHAVNDVSFDIYPGETFSLVGESGCGKSTTGKLIDHLITPDSGEIWFEGKEISRLSEKEMRPLRSDIQMVFQDPYGSLNPRMKVQDLIGEPLLIHTNMSAGERLKKVHELLGTVGLSPSHGERYPHEFSGGQRQRIGIARALTVQPKLIIADEPVSALDVSIQAQVLNLLQQLQKDFNLTYLFISHDLSVVEMISDRIGVMYLGTIVETAPKKELYANPRHPYTRALLSAVPIPDPEVKKERITLKGDLPSPSNPPSGCLFHTRCPHCTEKCKTQVPTPVEIAPGHIVKCHYPELTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NA31</accession>
    <name>A0A174NA31_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-ribose-binding periplasmic protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rbsB_3</name>
        <name evidence="3" type="synonym">rbsB_2</name>
        <name evidence="3" type="ORF">ERS852478_02297</name>
        <name evidence="4" type="ORF">ERS852523_01644</name>
        <name evidence="5" type="ORF">GT712_12870</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP44576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055150866.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000081_gene3050"/>
    <dbReference type="EnsemblBacteria" id="CUO26154">
        <property type="protein sequence ID" value="CUO26154"/>
        <property type="gene ID" value="ERS852478_02297"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP44576">
        <property type="protein sequence ID" value="CUP44576"/>
        <property type="gene ID" value="ERS852523_01644"/>
    </dbReference>
    <dbReference type="GeneID" id="66494415"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014252060" evidence="1">
        <location>
            <begin position="27"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="45"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO26154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP44576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="371" mass="38478" checksum="44F05C9689B1F0C7" modified="2016-09-07" version="1">MKAKKVIALVMCAAMVAGMSASSVMAADMPEQFKDLKANEAYDFPMMVKSFQSTYWDAAQEGMKKAADELGVTYKAQGPNSESDIADQVNMINTAIAAKPAGLGLAACDTSSVLDALQECADKGIPVVTFDTGIADAPEGSVVCEVCTDNTQAGSVAAENMYNSIKDVIANADGQVIIGEVNQDATGQNIQQRGGGFIDKMIELIQADGKTVAVKGNEFYVNAAKGADAKEADADVVIQVAVPAQTTVELCSTEAQAILSQENCIAIFGSNQTAAEGVLAANANLNVLGSDAGAGDVIGVGFDAGSIIKAAVQDGTFIGAVTQSPLMMGYYAIYALTAAANGQELEDVPTDGYWYDSTNMDSEEIAPNLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NZN6</accession>
    <name>A0A174NZN6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell division topological specificity factor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Cell division topological specificity factor MinE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">minE</name>
        <name evidence="7" type="ORF">BWLFYP14_02629</name>
        <name evidence="3" type="ORF">ERS852478_00131</name>
        <name evidence="4" type="ORF">ERS852523_01859</name>
        <name evidence="6" type="ORF">GT712_00805</name>
        <name evidence="5" type="ORF">GT728_15940</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MinE family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP51309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000047">
        <property type="protein sequence ID" value="MZL34644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993911.1">
        <property type="nucleotide sequence ID" value="NZ_JADPFJ010000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000020_gene94"/>
    <dbReference type="EnsemblBacteria" id="CUN44572">
        <property type="protein sequence ID" value="CUN44572"/>
        <property type="gene ID" value="ERS852478_00131"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP51309">
        <property type="protein sequence ID" value="CUP51309"/>
        <property type="gene ID" value="ERS852523_01859"/>
    </dbReference>
    <dbReference type="GeneID" id="66495893"/>
    <dbReference type="eggNOG" id="COG0851">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1070.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005527">
        <property type="entry name" value="MinE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036707">
        <property type="entry name" value="MinE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03776">
        <property type="entry name" value="MinE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55229">
        <property type="entry name" value="SSF55229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01215">
        <property type="entry name" value="minE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN44572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP51309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL34644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS87664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="95" mass="11224" checksum="7D601E90B08C3AED" modified="2016-09-07" version="1">MKAFFKEKKRSAGYARDRMKLLLISERIDCSPQMMKMLRNDMIHTVKKYLTIDEEQVKIQITQEPAVLHAYIPVLNKKDNRLVSSQLLKRTDKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174RUA0</accession>
    <name>A0A174RUA0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">rplL</name>
        <name evidence="11" type="ORF">BWLFYP14_03379</name>
        <name evidence="7" type="ORF">ERS852478_02936</name>
        <name evidence="8" type="ORF">ERS852523_03111</name>
        <name evidence="10" type="ORF">GT712_01090</name>
        <name evidence="9" type="ORF">GT728_08600</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000039">
        <property type="protein sequence ID" value="CUP87267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000016">
        <property type="protein sequence ID" value="MZL33254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705176.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000068_gene3401"/>
    <dbReference type="EnsemblBacteria" id="CUO47447">
        <property type="protein sequence ID" value="CUO47447"/>
        <property type="gene ID" value="ERS852478_02936"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP87267">
        <property type="protein sequence ID" value="CUP87267"/>
        <property type="gene ID" value="ERS852523_03111"/>
    </dbReference>
    <dbReference type="GeneID" id="66494699"/>
    <dbReference type="eggNOG" id="COG0222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="57"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO47447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP87267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS87719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX67102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="123" mass="12868" checksum="50D2189587498B49" modified="2016-09-07" version="1">MAKLTTEEFIAAIKELSVLELNDLVKACEEEFGVSAAAGVVVAAAGAAEAAEEKDEFDVELAEVGPNKVKVIKVVREVTGLGLKEAKEMVDGAPKVVKEGASKAEAEDIKTKLEAEGAKVNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174S727</accession>
    <name>A0A174S727_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Inner membrane ABC transporter permease protein ycjP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ycjP_17</name>
        <name evidence="7" type="synonym">ycjP_19</name>
        <name evidence="7" type="ORF">ERS852478_03004</name>
        <name evidence="8" type="ORF">ERS852523_03208</name>
        <name evidence="10" type="ORF">GT712_01400</name>
        <name evidence="9" type="ORF">GT728_10085</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
            <strain evidence="8 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BIOML-A1</strain>
            <strain evidence="10 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO49978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000042">
        <property type="protein sequence ID" value="CUP90229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000021">
        <property type="protein sequence ID" value="MZL33537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705044.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000010_gene2786"/>
    <dbReference type="EnsemblBacteria" id="CUO49978">
        <property type="protein sequence ID" value="CUO49978"/>
        <property type="gene ID" value="ERS852478_03004"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP90229">
        <property type="protein sequence ID" value="CUP90229"/>
        <property type="gene ID" value="ERS852523_03208"/>
    </dbReference>
    <dbReference type="GeneID" id="66495442"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO49978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP90229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS87779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="296" mass="32804" checksum="6E4622E6752E220B" modified="2016-09-07" version="1">MVRSKSAKRFERLAHTVMILVTICIVLPFILLFMSSITSESALVRDGYSFFPKEFSIHAYKFIWDNAANVFRAYGITILVTVIGTSINVAMSALLAYPLSLKNLPGKRILNFYIFFTMLFNGGLVPTYLMYTGIFHINNTLLAYIVPGLLMSAMNVMLIRTFFATSIPDALFEAAQIDGASQFQIFFKIVLPLGKPILIAMGLLSGLGYWNDWTNGLYYIRDTKLYGIQNLLNKMISDLTALTQNASGASTVAIADIPSASVRMAIAFVAMLPILCLYPFLQRYFTKGIALGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WZX8</accession>
    <name>A0A173WZX8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02649</name>
        <name evidence="2" type="ORF">ERS852478_00151</name>
        <name evidence="3" type="ORF">GT712_00700</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052825.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000145.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45033">
        <property type="protein sequence ID" value="CUN45033"/>
        <property type="gene ID" value="ERS852478_00151"/>
    </dbReference>
    <dbReference type="GeneID" id="66495872"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN45033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS87645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="208" mass="23754" checksum="ABB861BD75D7F87C" modified="2016-09-07" version="1">MELINNLFQFAVTLLGFCLSGIWYLKDRKQTCFLLTCFYGCFALGSLYWTLYLLLFSETPQVFYVSEFGWIASVIFLYLLQYTLSSAEERDFSTRKSLIAPLIGIPLCVFYCTFGDVLSNLLWCSMMIVVSYHSIRGLIYALIQTGTARKIRYFHIGVLCYVAVEYALWLSGCLWPGYSISNPYCWFDLLLTGCLFALLPATGKAVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X0H0</accession>
    <name>A0A173X0H0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsmH_1</name>
        <name evidence="6" type="synonym">rsmH</name>
        <name evidence="7" type="ORF">ERS852478_00154</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579043.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45104">
        <property type="protein sequence ID" value="CUN45104"/>
        <property type="gene ID" value="ERS852478_00154"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN45104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="351" mass="39984" checksum="714E6DDDF821485E" modified="2016-09-07" version="1">MENQNQTPHKRRVRYKGKYPKKFEEKYKELQPEKYKDTIEHVIQKGNTPAGMHISIMVKEILDFLNIQPGETGFDATLGYGGHTKAMLQCLNGKGHIYATDVDPEESAKTKKRLAEQGFGEELLTVKLQNFCTIDEIAKEVGGFDFILADLGVSSMQIDNPKRGFSFKTDGPLDLRLNQETGISAARRLDTISREELAGMLCENSDEPYCEELAKAITDEIRRGNHIDTTTKLRQVIEKTLDFLPEKEKKETIKKTCQRTFQALRIDVNHEFEVLYEFMEKLPDALRPGGRVAILTFHSGEDKLVKKALKAGYKEGIYSDYAKDVIRPSAKECTQNPRARSTKMRWAIKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XER9</accession>
    <name>A0A173XER9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="25"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN49397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="300" mass="34062" checksum="20B9BEAC08ED6216" modified="2016-09-07" version="1">MVYAKGGTSQFSGGKGNVMKMNVYQEISQIIKEADGILIGASNGLSIAEGYNIFADDAWFQKNMGDFREKYGLRCVLHGFSVPMKVEEKWAFVSRLVKAKAMQDEPSEIMKNIYALVKDKEYFVVTSNAEDHFVPAGFEADRVFEMEGKLTQMRCKNRCHDEVYPNQKAVLAMTEEEVNGRVPKELLPKCPKCGGDMEVNWGEMSSFTETKNWKEKAARYQEFIQNLHGKKLVILEFGIGWRNQMIKAPLMQLAAVEPQARYITFNKGEIYIPEEIKEKSIGVDGNLTVALKEIRKGRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XG52</accession>
    <name>A0A173XG52_9FIRM</name>
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        <submittedName>
            <fullName evidence="2">Probable ABC transporter-binding protein DR_1438</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="ERS852478_00312"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SBP"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN50719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="427" mass="46950" checksum="BDC247A243A4176E" modified="2016-09-07" version="1">MKKATLHKVTAIGMIAALTASQSAVVFAEEGDSSDKITLTFAFDEGVGTPTEEAIKAFNESQDEIEVQSYHLPQDANNLHDDFVNKMVAGDTSVDLMALDVVYIAEFASAGWIEALDDLYTEDELSAYLDGTVEGAKYDGKLYAAPWFTNASALFYRTDVLEDLGITEVPTTYQGWIDVYEKLAKDSGIDYAFCYQGAQSEAMVCNWVEFLASFGASVLDEDGKPVCDSKEAVEATQLMADYIGKYAPEGTTTYTETESQQVFQEGKALTCRTWSGTWNTFNDPEQSDVAGNVGMTMLPVYKEGDTSHSCLGGLDLAINSNIDDKQKEAAKTFIKWMTSEEEEKAFCLSSSQPPTVKDVYTDADVLEQIPFYKDFYSIIENGKGRPSSPDYSLLSDAIQRNVHSALTKEESAEDALKALQKEAEQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XIA6</accession>
    <name>A0A173XIA6_9FIRM</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized BCR, YitT family COG1284</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
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    <reference evidence="2 3" key="1">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577542.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51363">
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        <property type="gene ID" value="ERS852478_00334"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2364">
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    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN51363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="211" mass="23371" checksum="62F985CD213722F4" modified="2016-09-07" version="1">MSEWIRKINWKYVVVMLIGNVILGLGIAIFKLSGLGNDPFSGMVMALAECVGIEYARFLILLNLGFFVIEIIWGRKLIGLGTIINALFLGYFVTFFYNLITSVIDAPDQMAMQVVTVFIGVIITSLGISMYQLPKQGVAPYDSISLIMTEKWPKIPYFWCRVSNDAISALVCWLAGGIVGLGTLVSAFGFGPFVQFFDTHFTSKVLAKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XMH9</accession>
    <name>A0A173XMH9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nickel-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nikA_1</name>
        <name evidence="3" type="ORF">ERS852478_00341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199577.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51598">
        <property type="protein sequence ID" value="CUN51598"/>
        <property type="gene ID" value="ERS852478_00341"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
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        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
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        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015531" evidence="1">
        <location>
            <begin position="27"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="76"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN51598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="512" mass="56371" checksum="E0B3DB75A093FEFE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XNV0</accession>
    <name>A0A173XNV0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3796 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF3796)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00405</name>
        <name evidence="3" type="ORF">ERS852523_04332</name>
        <name evidence="4" type="ORF">GT712_06365</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000103">
        <property type="protein sequence ID" value="CUQ19397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000009">
        <property type="protein sequence ID" value="MZS88707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579173.1">
        <property type="nucleotide sequence ID" value="NZ_WWVP01000070.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53561">
        <property type="protein sequence ID" value="CUN53561"/>
        <property type="gene ID" value="ERS852478_00405"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ19397">
        <property type="protein sequence ID" value="CUQ19397"/>
        <property type="gene ID" value="ERS852523_04332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024257">
        <property type="entry name" value="DUF3796"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12676">
        <property type="entry name" value="DUF3796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ19397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="213" mass="25184" checksum="EA4609BFD3FA0F84" modified="2016-09-07" version="1">MSKKQIKKIIFMGVGCALLLIVGTIYSLLYNDGRWVKNMDMSEYVFSYKDIPMLVIGALIALYAIYIVIICFKNVFSKNSREKRYSRTISPYWGFCGMFGFLGFGGFWTYYKFGEIFPFAFFIFFGFFSFFFEGKLSHILEDELFQENKRKAQLEAYKIGFKLLFVVIWLMAIGMFSRNVEWCAIFMLISVSLIYALVLFLSNYLLYRYEKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XQ37</accession>
    <name>A0A173XQ37_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen synthase</fullName>
            <ecNumber evidence="7">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">glgA1_1</name>
        <name evidence="7" type="synonym">glgA</name>
        <name evidence="12" type="ORF">ERS852478_00388</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199595.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53056">
        <property type="protein sequence ID" value="CUN53056"/>
        <property type="gene ID" value="ERS852478_00388"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 7 12" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015584" description="Glycogen synthase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_transf_5" evidence="11">
        <location>
            <begin position="86"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="10">
        <location>
            <begin position="377"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN53056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="566" mass="64208" checksum="2F89707359A5AE95" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XRM1</accession>
    <name>A0A173XRM1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380948.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54541">
        <property type="protein sequence ID" value="CUN54541"/>
        <property type="gene ID" value="ERS852478_00438"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN54541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="145" mass="16096" checksum="8E8F8513A6B166E1" modified="2016-09-07" version="1">MSAKTKIIVLHMKEVIYTGIFLLLAVILAIVLFFMFGPGQKKSTSADAKSLYKPGIYTSSIDLNENTFDLEVTVDSDRVTSIRLVNLSESTAAMFPLMEPALESLASQIYTSQSLENIQYSEDQKYTSMILLNAIETALKKAENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XSN6</accession>
    <name>A0A173XSN6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Alpha/beta fold hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00398</name>
        <name evidence="3" type="ORF">ERS852523_01588</name>
        <name evidence="4" type="ORF">GT728_06340</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000013">
        <property type="protein sequence ID" value="CUP42706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000011">
        <property type="protein sequence ID" value="MZL32830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055150824.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000034_gene3880"/>
    <dbReference type="EnsemblBacteria" id="CUN53368">
        <property type="protein sequence ID" value="CUN53368"/>
        <property type="gene ID" value="ERS852478_00398"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP42706">
        <property type="protein sequence ID" value="CUP42706"/>
        <property type="gene ID" value="ERS852523_01588"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP42706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="277" mass="31994" checksum="386378C46CB2727F" modified="2016-09-07" version="1">MIENSYKTLCGCIHYFVNIIDKQKITLVFLPGLTADHRLFEKQIEYFEKKQNVFVWDAPSHALSRPFTNNYSLSDMAEWLDEILTKEEIYNPIIIGQSMGGYLAQMYMELYPDKIKGFIAIDSAPLQKSYMTAMEIWLLERAEPLYKIYPWKALLRAGSKGCAETDYGQSLMRKMMMSYDSDPKEYARLAGFGYRMLAEAIKADLPYHISCPALLICGEKDKAGSAKSYNKKWHQREGLPLKWIKNAGHNSNTDQPDEVNRLIEKFISEVDRRGVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y0J8</accession>
    <name>A0A173Y0J8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartate ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aspA</name>
        <name evidence="4" type="ORF">ERS852478_00508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57691">
        <property type="protein sequence ID" value="CUN57691"/>
        <property type="gene ID" value="ERS852478_00508"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008797">
        <property type="term" value="F:aspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="2">
        <location>
            <begin position="17"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="3">
        <location>
            <begin position="409"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN57691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="474" mass="51977" checksum="8E7201CC0D6F172A" modified="2016-09-07" version="1">MKKIDYRVERDSIGVKDIPEDVYYGVQSLRAAENFHITGLNMHPEIINSLAYIKKAAAITNCEVGLLEKKKAQAIVQACDEIVSGKFHNEFIVDPVQGGAGTSLNMNANEVIANRAIEILGGKKGDYTIINPNDDVNCGQSTNDVIPTAGKMTSLRLLQNLKKQLLRLYDALNEKATEFDHVIKMGRTQMQDAVPIRLGQEFKAYSVAIMRDIHRMDKAMDEMRTLNMGGTAIGTGINADEGYLRRIVPNLTEISGMDFIQAFDLIDSTQNLDPFVAVSGAVKACAVTLSKMSNDLRLMSSGPRTGFGEINLPAKQNGSSIMPGKVNPVIPEVVNQVAFNIIGNDVTITMAAEAGQLELNAFEPIIFYCMFQSIDTLGYAVQTLVDNCIVGITANEERCRYLVENSVGIITAISPHLGYQKAADIAKKAIKTGESVRSLILKEKLMDEDELNRILDPIHMTEPGISGKDYLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y2E1</accession>
    <name>A0A173Y2E1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Macrocin-O-methyltransferase (TylF)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199666.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56888">
        <property type="protein sequence ID" value="CUN56888"/>
        <property type="gene ID" value="ERS852478_00483"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008884">
        <property type="entry name" value="TylF_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40036">
        <property type="entry name" value="PTHR40036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05711">
        <property type="entry name" value="TylF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN56888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="286" mass="31540" checksum="3BEA1F59755A8D44" modified="2016-09-07" version="1">MMAKSVYKAVIFGAGQIGQMTARLLNSPCQLLCFADNDPHKHGSYIGNIPVCSPDAAVALLPDLVILGVLDEERRNSMIKQMENLGYHGPFRDPSVLRMFDARVAVMRLLSEQIYQLDIPGNVAELGVFRGEFSSLISAAFPDRKIHLFDTFEGFSEKDITIEASGNLSRAKTGDFSSTDIDSVIHVMPDPTRTVIHKGWFPDTFSDVRDETFCFVSLDADLYAPTAAALPLFYERLATGGVLLVHDVYSTQFSGCRKAVGEFCLKNHLFADPVCDLHGSAIIRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YD59</accession>
    <name>A0A173YD59_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_03254</name>
        <name evidence="3" type="ORF">ERS852478_00602</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX66977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578510.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60698">
        <property type="protein sequence ID" value="CUN60698"/>
        <property type="gene ID" value="ERS852478_00602"/>
    </dbReference>
    <dbReference type="GeneID" id="66492499"/>
    <dbReference type="eggNOG" id="ENOG5033XMU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252418" evidence="2">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN60698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="118" mass="12290" checksum="B82AAF8E98EAA046" modified="2016-09-07" version="1">MKKMIKRKTVILCMLLLGISVSGCGKTREVDEASSKVIQISVAPEETSPTPAPDQVASAAVTTNGNLTMVNTYLAEQDAAGISSAESSDSQSDADSTDNSVDSADNNEQDSSTSDTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YLQ0</accession>
    <name>A0A173YLQ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alpha-galactosidase</fullName>
            <ecNumber evidence="2 5">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rafA_2</name>
        <name evidence="10" type="ORF">ERS852478_00674</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2 5"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64156">
        <property type="protein sequence ID" value="CUN64156"/>
        <property type="gene ID" value="ERS852478_00674"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_36N" evidence="9">
        <location>
            <begin position="28"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_36C" evidence="8">
        <location>
            <begin position="648"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="366"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="476"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="548"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN64156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="739" mass="85331" checksum="46F890A3A099DE2E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YME2</accession>
    <name>A0A173YME2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xylose transport system permease protein xylH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">xylH</name>
        <name evidence="7" type="ORF">ERS852478_00679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199757.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64346">
        <property type="protein sequence ID" value="CUN64346"/>
        <property type="gene ID" value="ERS852478_00679"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN64346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="390" mass="41926" checksum="F5BF1AA9574CBE33" modified="2016-09-07" version="1">MEKKISFSEILKKYTMVIVLVLVVIMFAVNTKGVMLLPQNVNNLVAQNAYVFILATGMLFCILTGGNIDLSVGSVVCFVAAVGGKMMVLNSMNPYLTMLVMLITGIAIGAWQGFWIAYVRIPPFIVTLAGMLAFRGLSNVVLEGQTLAPMPDSYLALFNNYIPDPFGKEGFNLICFVVGIIVCIVYVLLVLKNRADRVKKGYSVDPFGGVAIKMILICVVILAFMFRLAQYKGIPNSLIWVAVIIAIYTYIASKTTTGRYFYAVGGNEKATKLSGINTNKVYFLAYLNMGLLAAIAGMVTMARLNSANPQAGTNFEMDAIGACFIGGASAYGGTGTVPGVIIGALLMGVLNLGMSIMGIDQNLQKVVKGLVLLAAVIFDVVSKRKSFIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YPL6</accession>
    <name>A0A173YPL6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1540 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Domain of Uncharacterized Function (DUF1540)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_01808</name>
        <name evidence="2" type="ORF">ERS852478_00700</name>
        <name evidence="3" type="ORF">ERS852523_00644</name>
        <name evidence="5" type="ORF">GT712_03190</name>
        <name evidence="4" type="ORF">GT728_03735</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP12921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706523.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000016_gene3645"/>
    <dbReference type="EnsemblBacteria" id="CUN65025">
        <property type="protein sequence ID" value="CUN65025"/>
        <property type="gene ID" value="ERS852478_00700"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12921">
        <property type="protein sequence ID" value="CUP12921"/>
        <property type="gene ID" value="ERS852523_00644"/>
    </dbReference>
    <dbReference type="GeneID" id="66493477"/>
    <dbReference type="eggNOG" id="ENOG50330E2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011437">
        <property type="entry name" value="DUF1540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07561">
        <property type="entry name" value="DUF1540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="5"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1540" evidence="1">
        <location>
            <begin position="65"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN65025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP12921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="109" mass="11709" checksum="36190BF540708DAE" modified="2016-09-07" version="1">MTILKCSAMTCVYNKEQLCSKGDIDVTGENATSANETSCGSFRERTGSSMKDSYTDDCGCDKIQIDCKAHNCTYNDNCKCTASSIQVDGSNAHASSDTRCDTFQCHCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YV39</accession>
    <name>A0A173YV39_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00764</name>
        <name evidence="3" type="ORF">ERS852523_00578</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP11246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380503.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000036_gene2413"/>
    <dbReference type="EnsemblBacteria" id="CUN67377">
        <property type="protein sequence ID" value="CUN67377"/>
        <property type="gene ID" value="ERS852478_00764"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11246">
        <property type="protein sequence ID" value="CUP11246"/>
        <property type="gene ID" value="ERS852523_00578"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN67377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP11246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="305" mass="34140" checksum="E488CF187327572F" modified="2016-09-07" version="1">MQKTALVIMAAGIGSRFGKGIKQLAPVGTCGEIIMDYSIHDALEAGFNKVVFIIRKDLEEEFRRVIGERIEKITEVEYVFQELDDLPEGFTKPADRTKPWGTGQAVLAAKKVLDEPFIVINADDYYGKEAYVKVHDYLVQEQQKDGKLHICMAGFRLGNTLSDNGSVTRGICHIKNGQLTGVTETHDIFKTATGAESRNADGSVQELDVKDLVSMNMWGLTPDFMEVLEKGFEEFLSGLAPEDIKKEYLLPELVDHLIKNESAEVDVLETKATWFGVTYQEDKETVMRAFKNLTEAGIYPQGLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YYM9</accession>
    <name>A0A173YYM9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="8">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">metF</name>
        <name evidence="11" type="synonym">yitJ_1</name>
        <name evidence="11" type="ORF">BWLFYP14_01742</name>
        <name evidence="9" type="ORF">ERS852478_00779</name>
        <name evidence="10" type="ORF">ERS852523_02960</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
            <strain evidence="10 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000036">
        <property type="protein sequence ID" value="CUP83134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706435.1">
        <property type="nucleotide sequence ID" value="NZ_WWVM01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000011_gene3447"/>
    <dbReference type="EnsemblBacteria" id="CUN67858">
        <property type="protein sequence ID" value="CUN67858"/>
        <property type="gene ID" value="ERS852478_00779"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP83134">
        <property type="protein sequence ID" value="CUP83134"/>
        <property type="gene ID" value="ERS852523_02960"/>
    </dbReference>
    <dbReference type="GeneID" id="66493553"/>
    <dbReference type="eggNOG" id="COG0685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase (NAD(P)H) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN67858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP83134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX64909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="292" mass="31834" checksum="9B3D5CF778E0DB81" modified="2016-09-07" version="1">MKMKELFDRGEFVVSAEVGPPKGIHVDELVEEAKTYLKDVHAVNVTDNQSSVMRLGSLAMCKVLKDAGMNPIFQLACRDRNRIALESDLLSAAMLGIDNILCLTGDHTKMGDHPQAKPVFDLDSVSLLHTVKLLESGVDLGGNELVGEPPKFSKGAVVSPCSDSVDAQLAKMERKVAAGAEYFQTQAVFEPEKFIKFMEKAKQFGKPVQVGIIIPKSAGMAKFMNNNVAGIHVPDEMLEELKADKEKTKAGITGVEIAARIIKECKPYCQGVHIMALGWESKIPDLLKLAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YZ59</accession>
    <name>A0A173YZ59_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CysJI operon transcriptional activator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional regulator CysL</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysL_1</name>
        <name evidence="6" type="ORF">BWLFYP14_01719</name>
        <name evidence="3" type="ORF">ERS852478_00802</name>
        <name evidence="5" type="ORF">GT712_02750</name>
        <name evidence="4" type="ORF">GT728_12505</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">BIOML-A1</strain>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000030">
        <property type="protein sequence ID" value="MZL34000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993634.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68743">
        <property type="protein sequence ID" value="CUN68743"/>
        <property type="gene ID" value="ERS852478_00802"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN68743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX64863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="281" mass="32857" checksum="6EF5E08FA3EB812A" modified="2016-09-07" version="1">MLDHRTETFMAVCSVMNYREAAELLHITQPAVTQHIQFLEKEYGCRLFLYENRKLIKTPAAQMLEDYLRSVQQRENFLREKIKNNGLRELRIGATKTIGDYVITDRIHDFLNQPDTALTLIVDNTKHLLHLLEQNTLDYAIIEGFFDKNRFGSQLYRREPFVGICPKDHPFAGREVSVEEILKETLIHRENGSGTLAILEEKLLEHNESLERFHRHICISSFKMIIDLIKSGYGISFVYEVLAKSDPDLGIFTLKGEPIVREFNVIYLKHADVREKMEWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YZI4</accession>
    <name>A0A173YZI4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RloB domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01729</name>
        <name evidence="2" type="ORF">ERS852478_00792</name>
        <name evidence="4" type="ORF">GT712_02810</name>
        <name evidence="3" type="ORF">GT728_12565</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000030">
        <property type="protein sequence ID" value="MZL34011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706409.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68325">
        <property type="protein sequence ID" value="CUN68325"/>
        <property type="gene ID" value="ERS852478_00792"/>
    </dbReference>
    <dbReference type="GeneID" id="66493565"/>
    <dbReference type="eggNOG" id="ENOG502Z98R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025591">
        <property type="entry name" value="RloB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13707">
        <property type="entry name" value="RloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN68325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="220" mass="25435" checksum="2B2791EA125D69A8" modified="2016-09-07" version="1">MNRPKNNKIRRPQFLCIVGCEGKNQERIYFDKVAELVNCVEERTHDLVFDYAEPYGGNPKCVVERTIQKSIGKENKVSVFDYDGKKDKYEEAIDLAIENKIELGYTNYCFDLWLILHKEDYFDIVQNQDAYADKLRQVFGLAADANIKKEKRVTEIVNQIGLSDIKNAIQRGKKISEDNQGKEANKTPKENRYYDNPDTQMHVLLQFLFAKVGINIDALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YZL3</accession>
    <name>A0A173YZL3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_01733</name>
        <name evidence="1" type="ORF">ERS852478_00788</name>
        <name evidence="3" type="ORF">GT712_02820</name>
        <name evidence="2" type="ORF">GT728_12580</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">BIOML-A1</strain>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000030">
        <property type="protein sequence ID" value="MZL34014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993631.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68188">
        <property type="protein sequence ID" value="CUN68188"/>
        <property type="gene ID" value="ERS852478_00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN68188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL34014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS88043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="277" mass="30725" checksum="CB4335F09A7F6CB3" modified="2016-09-07" version="1">MSKKMRLWMAGTVGVLMAGFMSVSVYALEEKDVIGTWYVNELSMGEGASFHPGAMGMEVTVDIKEDGKMETTSSVYGEEPEVDESEWKIENDKILMTHNDQTGECEYKDGKITLTADGTTMILSQEKEEYEPYVPGKPVENPTMKDFEGEWSCTLMEAFGMQMPVNADFTGFEMSMSVEDGKAEIILIESGEETKVELQGDVEGNALVLKAVTEDEAGTMFFSLDNMKFNLLDDGKLCLIAEDDAEESDDGEEADDSETGEVDFSVKTYFEKIIVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z101</accession>
    <name>A0A173Z101_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_00841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69964">
        <property type="protein sequence ID" value="CUN69964"/>
        <property type="gene ID" value="ERS852478_00841"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="6">
        <location>
            <begin position="179"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="7">
        <location>
            <begin position="320"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN69964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="418" mass="49492" checksum="C07963C2EE6A7370" modified="2016-09-07" version="1">MLLSKKTSIKVSREYANLIGHMCYAASKLWNVCNYERQHYKETGMEQYPDWYYQKKAHKEDLWYKQLPSQTAQEVCRLLDKAWKSFYALKRSGGIETPRPPRFKQESIPITYMQMGIVHERDTDRVRLSLPKTLKKYMEETYQIHENFLYLENKIFRGMDQIKQLWIYPPEKGNCKMIVVYEVPDQKELPQNGHELSIDLGLHNLMTCYDSENGKTFILGRKYLELERYFHKKIARVQAQWYGQQSGKGVKHPVTSKHIRKLYKRKQDSVTDYLHKITRYLAEYCREQGITCVVTGDIRNIRREKDLGRRTNQKLHSLPYNRIYIMLEYKLKRYGIRFVKQEESYTSQCSPLSPEVGKRYAEPSNRKERGSYRDGNRVYNADAVGAYNILRKYHSVSGVKKELSVTGLKTPEIIKVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZAE5</accession>
    <name>A0A173ZAE5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059450.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73392">
        <property type="protein sequence ID" value="CUN73392"/>
        <property type="gene ID" value="ERS852478_00928"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032VJN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN73392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="254" mass="28730" checksum="21D8D074007ED3D1" modified="2016-09-07" version="1">MQKQKRGFWLFIFSLIPGAGEMYMGFKKQGISIMFLFWGVFAIGACTGMDWLVFLIPIIWFYSFFNVHNLKSLSEEEFYSIEDSYVLHMDELAGDISSLLKHHGKITAILLIFLGASILWNTLVDFLYMILPGYLADVIGRFTYHLPQLVIAAAIIFAGIYILTRKKDALDEEQPDSFTEEEHYWTPYRPYQQNISDITTDAAKNTTDTTNPDCCTDTDVTDNTTTGNPVSLKKDSAAEVSQKDASSQTTNSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZGN9</accession>
    <name>A0A173ZGN9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjO_5</name>
        <name evidence="7" type="ORF">ERS852478_00987</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75287">
        <property type="protein sequence ID" value="CUN75287"/>
        <property type="gene ID" value="ERS852478_00987"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="71"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN75287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="299" mass="33687" checksum="33D8EED2C2EC89C6" modified="2016-09-07" version="1">MNKVKKMLYSQKVAPYVFVLPFVISLLVFWLYPLISGIVMSFQDISFGGSQWVGLKHYQKLASDKFFKTAVFNSVEYMLLTLLLLIPIPMLLAVLMESRLTKAKGVWKVIMYIPALTSVVISGMLFRLMFSEGDNGQMNQLMHLLGNASIPWLKEKTTGWVALLLLCMWRWTGVNMLYFISGLKSIDTSLYESADIDGANAKQKFWYLTLPLLKPTTIYVVTISVYAGLSMFLESFMLWNGNSSPKNIGLTIVGYLYKRGIEKNDMGYACAVGMVLLVIALAINIVQLVATGTFKKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZI42</accession>
    <name>A0A173ZI42_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75904">
        <property type="protein sequence ID" value="CUN75904"/>
        <property type="gene ID" value="ERS852478_01005"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="31"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="183"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="411"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN75904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="540" mass="62872" checksum="BEFD92A562959444" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZJY9</accession>
    <name>A0A173ZJY9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module antitoxin, RelB/DinJ family</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Type II toxin-antitoxin system RelB/DinJ family antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01021</name>
        <name evidence="3" type="ORF">GT712_17285</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000049">
        <property type="protein sequence ID" value="MZS90762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_044956362.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76387">
        <property type="protein sequence ID" value="CUN76387"/>
        <property type="gene ID" value="ERS852478_01021"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN76387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="90" mass="10478" checksum="1C638F1FD6227802" modified="2016-09-07" version="1">MTTISLRMDDQMKKELDEMCEAMGMNISTFYMIYTKKALRDRRIPFDIEAPADPFYSEQNMAQLRKSAQQVKEGKIITKTMEDLEAIACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZQ50</accession>
    <name>A0A173ZQ50_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Swarming motility protein YbiA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ybiA</name>
        <name evidence="5" type="ORF">BWLFYP14_00325</name>
        <name evidence="4" type="ORF">ERS852478_01045</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:137796"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-6-(5-phospho-D-ribosylamino)uracil + H2O = 5,6-diaminouracil + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:55020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:46252"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058805.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78167">
        <property type="protein sequence ID" value="CUN78167"/>
        <property type="gene ID" value="ERS852478_01045"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="SSF143990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="3">
        <location>
            <begin position="6"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN78167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX67480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="157" mass="18237" checksum="389E6B3730F3B14F" modified="2016-09-07" version="1">MNVICFHNPDEENGYLSNWYLSHFTVNGIDFSSMEQFMMYQKAYRFHDEEIANDILHTDNVAEIKKLGRKVHAYDENVWNGVRQIIVYEGLKAKFSQNAELKRQLVDTGDAVLAECAVRDQIWGIGLSMGDPNRFERSKWKGNNLLGYALMLVREQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZW61</accession>
    <name>A0A173ZW61_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative enoyl-[acyl-carrier-protein] reductase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380903.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000067.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80093">
        <property type="protein sequence ID" value="CUN80093"/>
        <property type="gene ID" value="ERS852478_01099"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="11"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN80093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="349" mass="37820" checksum="A39ADFDCC766B2DC" modified="2016-09-07" version="1">MKNFKIGDKITRVPLIQGGMGVGISLGRLAGSVAKAGGVGIISTAQIGYREEDFDRNPAAANERAIAGEMKKAREISGDGIIGYNIMVALKEYASHVKAAVKAGADIIISGAGLPTELPELVKGSLTKIAPIVSTEKSAKVILKYWDRKYKRTADLVVIEGPQAGGHLGFHKEELEKYTEESYSEEIKKIITTVKSYAEKYGTEIPVIVAGGIYNREDVRKVDNLGADGIQVATRFITTEECDADIRYKEAHLKAKESDIAIVKSPVGMPGRAIMNKFMTRVMNGEQIPHSPCHGCLVKCSPKEIPYCITDGLINAVKGNVDEGLLFCGAKAWKAEHLQTVQEVINDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A1R6</accession>
    <name>A0A174A1R6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoIVB peptidase</fullName>
            <ecNumber evidence="2">3.4.21.116</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoIVB</name>
        <name evidence="2" type="ORF">ERS852478_01171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.116" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82612">
        <property type="protein sequence ID" value="CUN82612"/>
        <property type="gene ID" value="ERS852478_01171"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014219">
        <property type="entry name" value="Pept_S55_SpoIVB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008763">
        <property type="entry name" value="Peptidase_S55"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05580">
        <property type="entry name" value="Peptidase_S55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02860">
        <property type="entry name" value="spore_IV_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51494">
        <property type="entry name" value="SPOIVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S55" evidence="1">
        <location>
            <begin position="176"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN82612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="405" mass="44518" checksum="03BEE78648C8804C" modified="2016-09-07" version="1">MNKRKYRLFVICCLVLDLLVMLISGYRYLDRKIPDEIQISRGKKTEDVTEVLSTPFVTFEEAVTVSQDGGYILPCKLLGYIPFKEIKVTPADDQEIYVSGSTIGIYMQTEGVLVIDTGEIQNRNGETEEPARNIIRQGDYIISFNGEKISTKRELIDDISELDGSEVTLGISRKGESIPVSVTPVKDKKGDYKLGIWVRDDTQGIGTLTYVDQNGNYGALGHGISDIDTAQLLNIRNGALYKARILAINKGSKGNPGELAGYICYDDRNILGTIEANSRNGIYGQFTGIADDAITLKKMPAAYKQEVKIGTATILCSADGEVKEYDAEIRKIDLNHEDTNKSFVIKVTDKELLEATGGIVQGLSGSPVIQNGKIIGAVTHVFVQDASSGYGIFIENMLKNTERLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A1W7</accession>
    <name>A0A174A1W7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biotin carboxylase</fullName>
            <ecNumber evidence="5">6.3.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetyl-coenzyme A carboxylase biotin carboxylase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">accC_1</name>
        <name evidence="9" type="synonym">accC_2</name>
        <name evidence="9" type="ORF">BWLFYP14_03088</name>
        <name evidence="8" type="ORF">ERS852478_01146</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059529.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81800">
        <property type="protein sequence ID" value="CUN81800"/>
        <property type="gene ID" value="ERS852478_01146"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004549">
        <property type="entry name" value="Acetyl_CoA_COase_biotin_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00514">
        <property type="entry name" value="accC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN81800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="448" mass="49854" checksum="D7682CE5D6200043" modified="2016-09-07" version="1">MFNKILIANRGEIAVRIIRACREMGIRTVAVYSEADRDALHTQLADEAVCIGKAQSSDSYLNMERILSATIATKAEAIHPGFGFLSENSRFVEMCEKCNVAFIGPSAEVISRMGNKSEAKNTMRKAKVPVVPGTKEPVYTVEQALEAVKEIGFPVMIKASAGGGGKGMRVAGNEQEFAKLFETAQQESVHSFSDNTMYLERFVENPRHVEVQILADKYGNVVHLGERDCSVQRRHQKMIEESPCIAISDDLRKKMGETAVRAAKAAGYESAGTIEFLLNQSGEFYFMEMNTRIQVEHPVTEFVSGVDLIKEQICIAAGEPLSVQQKDIEIRGHAMECRINAEDPERHFMPCPGKITDLHLPGGNGIRVDTAVYNDYAIPPYYDSMIAKIIVYDKDRRSAIRKMISALGEVAIEGVKTNVDFLYELLNQPDFQEGNITTDFIPQHYPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A2Z0</accession>
    <name>A0A174A2Z0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_03055</name>
        <name evidence="1" type="ORF">ERS852478_01179</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82884">
        <property type="protein sequence ID" value="CUN82884"/>
        <property type="gene ID" value="ERS852478_01179"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN82884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX66779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="39" mass="4363" checksum="7BDD822C91E7AF4F" modified="2016-09-07" version="1">MSNEKASIVCFEQFIEAFLTESSKSPALIAKSNKQWVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A8Y8</accession>
    <name>A0A174A8Y8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_03028</name>
        <name evidence="1" type="ORF">ERS852478_01206</name>
        <name evidence="2" type="ORF">ERS852523_00525</name>
        <name evidence="4" type="ORF">GT712_03790</name>
        <name evidence="3" type="ORF">GT728_00165</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP09062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704036.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000061_gene489"/>
    <dbReference type="EnsemblBacteria" id="CUN83996">
        <property type="protein sequence ID" value="CUN83996"/>
        <property type="gene ID" value="ERS852478_01206"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP09062">
        <property type="protein sequence ID" value="CUP09062"/>
        <property type="gene ID" value="ERS852523_00525"/>
    </dbReference>
    <dbReference type="GeneID" id="66494041"/>
    <dbReference type="eggNOG" id="ENOG5033DNC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045507">
        <property type="entry name" value="DUF6483"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20092">
        <property type="entry name" value="DUF6483"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN83996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP09062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL31646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="125" mass="14406" checksum="86A223582FEB71C9" modified="2016-09-07" version="1">MAVQDDHMIRNIQDVGRLIAKLLLHEQQPNYKLPEKEADYTEADRLFATIMKLAEEGKINEAENELYMGMVEDDVDYLELALTFYLYLNDMDGDFLDDNGYSREEVLEGMKDLASDWGVTGLEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ASK4</accession>
    <name>A0A174ASK4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">rpe_2</name>
        <name evidence="14" type="ORF">ERS852478_01382</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="12">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN91173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379840.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91173">
        <property type="protein sequence ID" value="CUN91173"/>
        <property type="gene ID" value="ERS852478_01382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="13">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN91173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="220" mass="24129" checksum="15BB2F9750B00FFF" modified="2016-09-07" version="1">MCIIAPSLLEADYKCLGEQLKTMEKSGAEYVHIDVMDGSFVPNLACGMKMIHGLKGVADLVFDVHLMVNEPVRFVKRMQEAGADVISVHYEACSNVAETLKEIKQCGIRAGIVLNPETSAEVLTEEIWKLADVIQVMTVHPGRDGQHFIEDTLDKIKDIRRRSTDTGEWKDIEVDGSINCGNIGKVIKAGANIIVSGKALFNGNLAENIANMKQQAAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AWZ8</accession>
    <name>A0A174AWZ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator immR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">immR_4</name>
        <name evidence="2" type="ORF">ERS852478_01392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN92653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200051.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN92653">
        <property type="protein sequence ID" value="CUN92653"/>
        <property type="gene ID" value="ERS852478_01392"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN92653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="196" mass="22266" checksum="6018F4024C155B87" modified="2016-09-07" version="1">MLGKRIKELRKQNHLTQSELGSKLGVIKQTVSSWENGVSSPNNDTLANIASIFGVTTDYLLGNDTSTTKQFIECRDISNRISKLAAHSRKNIEDLKPLLKTEILSGYYTDSSLFRSDIYTIADFYGVSDEYIIGGPEFEEQTYGNPLDEIAQKFLNVFLELNEDNRDIIIGDMKKLLKEQRREEALPTKMVHKQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AXV5</accession>
    <name>A0A174AXV5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200076.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93611">
        <property type="protein sequence ID" value="CUN93611"/>
        <property type="gene ID" value="ERS852478_01423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN93611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="69" mass="8116" checksum="91AF84B044B77050" modified="2016-09-07" version="1">MEKRICPECGKEYSSHPALSRKDNKTMICPKCGMMEALDAVRDFYAPGMTDQQWKQYKEGYMLKYIKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B3E8</accession>
    <name>A0A174B3E8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200117.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95347">
        <property type="protein sequence ID" value="CUN95347"/>
        <property type="gene ID" value="ERS852478_01477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN95347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="137" mass="16082" checksum="76451D5AC4A110A6" modified="2016-09-07" version="1">MNITEMRNYIGVSRAEFSRRYNIPIRTLESWESEVRTPPEYVLQLLEESVRRTDIVEVTFMYDTLLQEGKIHPWSKDDDQYGSDQAAYKTVLNIVDRFRERYPNCEWEDEDIDYIDAIEGFATNLLMATLGKGAANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B545</accession>
    <name>A0A174B545_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ion-translocating oxidoreductase complex subunit D</fullName>
            <ecNumber evidence="10">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Rnf electron transport complex subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">nqrB</name>
        <name evidence="10" type="synonym">rnfD</name>
        <name evidence="14" type="ORF">BWLFYP14_00987</name>
        <name evidence="11" type="ORF">ERS852478_01491</name>
        <name evidence="13" type="ORF">GT712_13095</name>
        <name evidence="12" type="ORF">GT728_10960</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">BIOML-A1</strain>
            <strain evidence="13 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NqrB/RnfD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000024">
        <property type="protein sequence ID" value="MZL33703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000026">
        <property type="protein sequence ID" value="MZS89982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380992.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95844">
        <property type="protein sequence ID" value="CUN95844"/>
        <property type="gene ID" value="ERS852478_01491"/>
    </dbReference>
    <dbReference type="GeneID" id="66492611"/>
    <dbReference type="eggNOG" id="COG4658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00462">
        <property type="entry name" value="RsxD_RnfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004338">
        <property type="entry name" value="NqrB/RnfD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011303">
        <property type="entry name" value="RnfD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578">
        <property type="entry name" value="PTHR30578"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03116">
        <property type="entry name" value="NQR2_RnfD_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01946">
        <property type="entry name" value="rnfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="modified residue" description="FMN phosphoryl threonine" evidence="10">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN95844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL33703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS89982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX63501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="325" mass="34966" checksum="CC6CFE1A307B55C4" modified="2016-09-07" version="1">MDQMLHVSSNPHVRDKMTTSKIMQLVALALLPATLFGIYNFGLRALLVVVITVASSVFFEWIYDKLMHKKNTITDFSAVVTGLLLALNMPASIPLWMPVLGSAFAIIVVKQLFGGLGQNFMNPALAGRCFLMISFAGKMTDFAVSDSFRGVVDTVSGATPLAALKQNGFTDSSVSVLHMFIGDIQGTIGETSALAILIGAAILLVFKVIDLKIPLTYIGSFAVFVILYMLGTGKGFDVNYLFSHIFGGGLMLGAWFMATDYVTTPITPRGQYVYGVCLGVLTAVFRLFGGSAEGVSYAIIFCNLLVPMIERVTRHPAFGKGGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BDN5</accession>
    <name>A0A174BDN5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA repair protein RadA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97845">
        <property type="protein sequence ID" value="CUN97845"/>
        <property type="gene ID" value="ERS852478_01544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="142"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN97845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="436" mass="48130" checksum="1C294B92BCE0B5AF" modified="2016-09-07" version="1">MFVFEAPIDLLSFLCLFKKDWQKQSYLSLGGVGDKALMRFLSDRPNIKTVYLCLDSDQAGNDACSRLAELVPEGLTVHRLLPLYKDWNEVLQHRAEITDGKYLREAVYGLKEPPQEETVEIIRMSEVDTQTVEWLWEPYIPFGKVTIVQGNPGEGKTTFALRLAAACTTGGTLPGMKSLPPFQVIYQTAEDGLGDTVKPRLMEAEADLDRVLVIDEAKRELNLSDERIEKAIVQNGARLIILDPIQAYMGEKTDMNRANEVRPMFRRLADVAERTGCAVILIGHLNKAAGGQSAYRGLGSIDFRAAARSVLLIGRVKREPNVRVIVHDKSSLAPEGKPVAFCLDPETGFSWIGEYDITADELLSGAGGNTATKTEQAERLILDLLADGKELASEDIEKAATEAGISARTVRAAKRNLDGRITSKRIGAAWYHALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BKQ6</accession>
    <name>A0A174BKQ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV secretory pathway, VirB4 components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00275">
        <property type="protein sequence ID" value="CUO00275"/>
        <property type="gene ID" value="ERS852478_01591"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043964">
        <property type="entry name" value="P-loop_TraG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19044">
        <property type="entry name" value="P-loop_TraG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P-loop_TraG" evidence="2">
        <location>
            <begin position="468"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO00275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="818" mass="94266" checksum="C474F21881520500" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BM03</accession>
    <name>A0A174BM03_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_01602</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057314.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00628">
        <property type="protein sequence ID" value="CUO00628"/>
        <property type="gene ID" value="ERS852478_01602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO00628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="245" mass="27855" checksum="01A79E7CFBA6DD8B" modified="2016-09-07" version="1">MCKIAICDDDKEYREKIKTVIETEGILSSNEIRFYEYESGKELLEDADILHDLIFMDMRMPGLDGNKTVLKLREYNEAAILVFCSGYFEPTSDSINIGQPFRYIMKDLHDRSLKREIPAILSKVKLHCGDSSVTVTSAGRVIRIYTEDILYICLAKRGCSIYVARQGEIDEIHCKESLGDLYERLAGRGFEYAHNSYIVNLAKVEGLEKNVALLQMGIQLNVSRSRKGQFADALIMFLGERNGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BM77</accession>
    <name>A0A174BM77_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Linear gramicidin dehydrogenase LgrE</fullName>
            <ecNumber evidence="3">1.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lgrE_1</name>
        <name evidence="3" type="ORF">ERS852478_01606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057316.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00785">
        <property type="protein sequence ID" value="CUO00785"/>
        <property type="gene ID" value="ERS852478_01606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO00785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="241" mass="27440" checksum="BC3C2FF9B7676203" modified="2016-09-07" version="1">MNLKLIKNTENINKEKITLFCLPFAGGGASAYNQWAKKMQGKVTVCPVQLPGREEQIMEKPYIDMSVMLDDLEEAVRKVVYGPYALWGHSMGGKIAYELEKRLEAAGYTAKCLFISGSRVPSIPEPNPIYHLPDEEFKRELGRFEGTPKEVLENQELLDFFLPMLRADFTMDETYYDKAGIVLHTPIAAFGGEKDGEADESAILEWGKYTDNDFNYRIFPGGHFYLRDCEDEVISEVMRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BN21</accession>
    <name>A0A174BN21_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenyloxazoline synthase MbtB</fullName>
            <ecNumber evidence="7">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mbtB_1</name>
        <name evidence="7" type="ORF">ERS852478_01609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057319.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00966">
        <property type="protein sequence ID" value="CUO00966"/>
        <property type="gene ID" value="ERS852478_01609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1423"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2474"/>
            <end position="2549"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="1458"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="5">
        <location>
            <position position="2509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO00966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="2562" mass="292758" checksum="71363F57E67A95C7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C711</accession>
    <name>A0A174C711_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uroporphyrinogen decarboxylase (URO-D)</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen-III decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_01202</name>
        <name evidence="2" type="ORF">ERS852478_01791</name>
        <name evidence="3" type="ORF">ERS852523_03624</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000057">
        <property type="protein sequence ID" value="CUQ01533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705416.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000014_gene1245"/>
    <dbReference type="EnsemblBacteria" id="CUO07690">
        <property type="protein sequence ID" value="CUO07690"/>
        <property type="gene ID" value="ERS852478_01791"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ01533">
        <property type="protein sequence ID" value="CUQ01533"/>
        <property type="gene ID" value="ERS852523_03624"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO07690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ01533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX63843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="344" mass="39025" checksum="2E4361DECA27AD2F" modified="2016-09-07" version="1">MLTPKQNMLEVIKGGNPDRFVNQYEAVQLLFHPFMFANPLLQPGQENVVNAWGVTNTFPKGVPGSFPVHTPDKIVVKDIEDWKDYVHAPSLKFTQDQWDMVKAQYDAVDGEQAFKAAFVAPGLFEQTHHLCEISNALVYYITNPDEMHDLIKYLTEWELELAEGICSNLHPDALFHHDDWGGLDSTFMSPAMFDEFLLEPYKEIYGYYHSHGVELVIHHSDSYAATLVPSMIEMGIDVWQGCMETNNLPELIRKYGGKISFMGGIENRAVDFEGWTDENCDAVVRRVCEECGNKYFIPCIAQGGPGSVYPGVYKSLCDSIDKLNEEKFGIKASESTRLPWQIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CBR2</accession>
    <name>A0A174CBR2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coenzyme A disulfide reductase</fullName>
            <ecNumber evidence="3">1.8.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cdr_1</name>
        <name evidence="3" type="ORF">ERS852478_01870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200392.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10912">
        <property type="protein sequence ID" value="CUO10912"/>
        <property type="gene ID" value="ERS852478_01870"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050451">
        <property type="term" value="F:CoA-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="465"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO10912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="564" mass="61535" checksum="4B48F642B0390DCE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CQR7</accession>
    <name>A0A174CQR7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rffG_1</name>
        <name evidence="8" type="synonym">rffG</name>
        <name evidence="8" type="ORF">BWLFYP14_00411</name>
        <name evidence="7" type="ORF">ERS852478_01991</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707535.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15474">
        <property type="protein sequence ID" value="CUO15474"/>
        <property type="gene ID" value="ERS852478_01991"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="4"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO15474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX62304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="342" mass="39158" checksum="F050609DA692E27D" modified="2016-09-07" version="1">MNIIVTGGAGFIGSNFIFHMLKKYPDYRIICLDCLTYAGNLSTLAPVMDNPNFRFVKESITDREAVYKLFEEEHPDMVVNFAAESHVDRSIENPEVFLTTNIIGTAVLMDACRKYGIKRYHQVSTDEVYGDLPLDRPDLFFTEETPIHTSSPYSSSKASADLLVLAYHRTYGLPVTISRCSNNYGPYHFPEKLIPLMIANALNDKPLPVYGTGENVRDWLYVEDHCRAIDLIIHKGRVGEVYNVGGHNEMTNIDIVKIICKELGKPESLITYVADRKGHDMRYAIDPTKIHNELGWLPETKFADGIKKTIKWYLDNKEWWETIISGEYQNYYEKMYANRGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D9W6</accession>
    <name>A0A174D9W6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4825 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200574.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20815">
        <property type="protein sequence ID" value="CUO20815"/>
        <property type="gene ID" value="ERS852478_02141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032250">
        <property type="entry name" value="DUF4825"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16107">
        <property type="entry name" value="DUF4825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4825" evidence="1">
        <location>
            <begin position="33"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO20815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="126" mass="14144" checksum="A1AFD100FD2915E2" modified="2016-09-07" version="1">MKRKILAIIPIVMLIISLSACGRKETLYEIPDLSQYKTDYVGDSSNVINIVSKQDYPEGYSYDSIEIQSETKPYGLTVFLKAEPSASMLEDELQVNADMTFDLIGNLGTLDYKTADSKEIIASYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DI90</accession>
    <name>A0A174DI90_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005428607.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000138.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24917">
        <property type="protein sequence ID" value="CUO24917"/>
        <property type="gene ID" value="ERS852478_02259"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO24917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="87" mass="9546" checksum="2D1BD87631EEDC95" modified="2016-09-07" version="1">MIGLILGNIMVVLGVFSIIKGKLPLIKRYNGVKNIKLHSRIEGTAILLVGIMLIFQCFISLGNVEIVIIILSICIFSLILEIALKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DR88</accession>
    <name>A0A174DR88_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BMC domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Propanediol utilization protein PduA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pduA_2</name>
        <name evidence="4" type="synonym">pduA_1</name>
        <name evidence="7" type="ORF">BWLFYP14_01563</name>
        <name evidence="3" type="ORF">ERS852478_02317</name>
        <name evidence="4" type="ORF">ERS852523_01624</name>
        <name evidence="6" type="ORF">GT712_12775</name>
        <name evidence="5" type="ORF">GT728_12260</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP44011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000029">
        <property type="protein sequence ID" value="MZL33952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705581.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000086_gene4006"/>
    <dbReference type="EnsemblBacteria" id="CUO26779">
        <property type="protein sequence ID" value="CUO26779"/>
        <property type="gene ID" value="ERS852478_02317"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP44011">
        <property type="protein sequence ID" value="CUP44011"/>
        <property type="gene ID" value="ERS852523_01624"/>
    </dbReference>
    <dbReference type="GeneID" id="66494434"/>
    <dbReference type="eggNOG" id="COG4577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020808">
        <property type="entry name" value="Bact_microcomp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01139">
        <property type="entry name" value="BMC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO26779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP44011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL33952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS89921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX64709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="91" mass="9165" checksum="11EA012DEB45B535" modified="2016-09-07" version="1">MAQEALGMVETRGLTAAIEAADAMTKAAEVALVGTEKIGSGLVTVMVRGDVGAVKAAVESGSAAASRLGELVATHVIPRPHTDVEKILPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E2N1</accession>
    <name>A0A174E2N1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt-precorrin-8X methylmutase</fullName>
            <ecNumber evidence="6">5.4.1.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Precorrin-8X methylmutase</fullName>
            <ecNumber evidence="7">5.4.99.61</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cbiC</name>
        <name evidence="9" type="ORF">BWLFYP14_00113</name>
        <name evidence="6" type="ORF">ERS852478_02423</name>
        <name evidence="8" type="ORF">GT712_04240</name>
        <name evidence="7" type="ORF">GT728_01885</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">BIOML-A1</strain>
            <strain evidence="8 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <dbReference type="EC" id="5.4.1.-" evidence="6"/>
    <dbReference type="EC" id="5.4.99.61" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL31984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704797.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30736">
        <property type="protein sequence ID" value="CUO30736"/>
        <property type="gene ID" value="ERS852478_02423"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="5">
        <location>
            <begin position="12"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO30736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL31984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS88320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="214" mass="23197" checksum="56199F04BDDE744E" modified="2016-09-07" version="1">MKVELENVKPMDIEKRSFEIITEELGDKKLVPGTELIVKRCIHTSADFDYAENLCFSENAVEKAIAAIKDGACIVTDTHMAESGINKRVLSRYGGEVFCFISDEDVAATAKANGTTRATASMDKAAAMGKKLIFAIGNAPTALVRLYELIEDGKLDPELIIGVPVGFVNVVQSKELIMQADVPYIVARGRKGGSNVAACICNALLYMIDNNRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E4V1</accession>
    <name>A0A174E4V1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CAAX amino terminal protease self- immunity</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">CAAX amino terminal protease self-immunity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02139</name>
        <name evidence="2" type="ORF">ERS852478_02481</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994004.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32793">
        <property type="protein sequence ID" value="CUO32793"/>
        <property type="gene ID" value="ERS852478_02481"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO32793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="283" mass="31923" checksum="1BCB689DAFD53472" modified="2016-09-07" version="1">MKIKCTFHIAIAFILIQLTDEFSIAFAYGICEKNPYVRILYVTFAILSLLTMIYLYTKYIIRIQMQDLFLGMPLPKKKWCITAVLMPVLICLFYIFFTKGTFEKGNLTYKEIIDVVTISILSSGIKAAVTEEIVFRGMILRLLQNTFGKKCAVFVSSFLFAVYHFDGIDTSDIKKVIMMIISVEIAGIALALVTEQTGSIWSSVMIHCLYNILSGESQIFHIDVAQNFPAIWMYTVNSKNMLLTGINGSVGFTASIPTMAGFTGIILMVIYDEKKKKTYGKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E914</accession>
    <name>A0A174E914_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33096">
        <property type="protein sequence ID" value="CUO33096"/>
        <property type="gene ID" value="ERS852478_02491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO33096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="282" mass="31646" checksum="A4EBAADFFBEEE994" modified="2016-09-07" version="1">MRKRNNFISVFTMFLAIGFAIIFSIPVKATANGVQLKANRTYTAYDVTGDGTKDKIRIRASNQTDDEAYSSLTVSVNGKTAYRLKNTRFYNVIANIYTLKNGQPFLYLYAPAENGDGPVCALLKYTNGKFRKALDFTEIMAGYGNHRIGEVTNLKGNKIVITESIVSYSLGINAINFTYKYVNGKFVPTSRYGSYKEIYSADGSSRYFTVNSDLPTYTRPDATAVNTTLKTGSLTKIIKCALINEKMYIQLECDGEIYWIKALENPPISDNERQFMEVRYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E9R8</accession>
    <name>A0A174E9R8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">prkC_2</name>
        <name evidence="9" type="ORF">ERS852478_02503</name>
        <name evidence="11" type="ORF">GT712_02340</name>
        <name evidence="10" type="ORF">GT728_13245</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">BIOML-A1</strain>
            <strain evidence="11 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000033">
        <property type="protein sequence ID" value="MZL34141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058421.1">
        <property type="nucleotide sequence ID" value="NZ_JADPFJ010000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33346">
        <property type="protein sequence ID" value="CUO33346"/>
        <property type="gene ID" value="ERS852478_02503"/>
    </dbReference>
    <dbReference type="GeneID" id="66495254"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO33346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL34141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS87961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="418" mass="47977" checksum="30A96544EF2DD4CC" modified="2016-09-07" version="1">MNLSGTVLKGRYCILEPVGKGGGGKVYLARDLELGVLWAVKEIPVSGKSEARMLLKLSHPSLPKMIDYIEDNRKCYLVMEYVRGKSLGEYLRGGKHFSINEIVKYGMEISDVFSYFHGRKPPVYYGDLKPDNLMLGENGRLYLIDLGGAVNGYKYHHKVCTGTAGFAAPEQYEGKINAATDIYTFGKTLSALCGKTDCLLFIRNMSLFWLIFRCCMKKPEMRYQNMKTVQKKLSRIQKRQNQSKIKNMLVLAGSSIAFAVITVFLLFSSNLVSGSKTFDFYEELTDITDLYYQEEFQNGSKADREKICEQADTGLRKLQKQCTEKEESRKILQILAVNSEYQENYENAGFYYEQMLLYDETYRAGYGEYGMFLFRTGQKEAGQALWTEYKSKETMLDDTVSRNLRLWEKEMTKSEEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EBD5</accession>
    <name>A0A174EBD5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacterial protein of uncharacterized function (DUF961)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003059926.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35162">
        <property type="protein sequence ID" value="CUO35162"/>
        <property type="gene ID" value="ERS852478_02550"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZZ52">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010365">
        <property type="entry name" value="DUF961"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038620">
        <property type="entry name" value="YdcP-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06125">
        <property type="entry name" value="DUF961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO35162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="108" mass="12374" checksum="77829778B5EA1439" modified="2016-09-07" version="1">MEMKYVVPDMAQSFGTLEFAGESEPIFERDKNNRRVLARRSYNLYSDVQKGENVVVEIPVQAGEKHFKYEQKVKLVNPKLYGRGYAIGDMGHTDYVLLADDIVAVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EBP2</accession>
    <name>A0A174EBP2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxyacylglutathione hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02518</name>
        <name evidence="4" type="ORF">GT712_02265</name>
        <name evidence="3" type="ORF">GT728_13320</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000033">
        <property type="protein sequence ID" value="MZL34156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703726.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33705">
        <property type="protein sequence ID" value="CUO33705"/>
        <property type="gene ID" value="ERS852478_02518"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="15"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO33705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS87946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="209" mass="23376" checksum="4F3A8A799041574E" modified="2016-09-07" version="1">MKNLELQKCILGPVYTNCYLLKNKETGELIIVDPADCLEKIEMKISRMNGKPVAILLTHGHFDHILAAQAVKEKYNIPIYACRQEEEMLREPSINMTVHYGQGCSIVPDVFLEDLDVIRLAGFSVQMIHTPGHTKGSCCYYLKDEGVLFSGDTVFYGSVGRTDFPGGSTAEIVRSLHKLVDSLPEETEVFPGHDASTTIGYEKRYNPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EBR1</accession>
    <name>A0A174EBR1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional regulator immR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">immR_6</name>
        <name evidence="3" type="ORF">ERS852478_02548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003061262.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35093">
        <property type="protein sequence ID" value="CUO35093"/>
        <property type="gene ID" value="ERS852478_02548"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO35093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="195" mass="22450" checksum="67FA134E3A5106AF" modified="2016-09-07" version="1">MDIGLQIKKFREQQKISQEELALKIFVSRQTISNWETNKSCPDVKSLITLSNIFNVSLDNFIKEDIKEMREIVEKATIKKFNVISVVFLIELIVVAISAYPLFSIKGNIGIIIWLCLFAITLYTASKIEKFKKSHDIQTYKEILAFIDGKQLTHDETQQEIGKRNYQKIIFAFIAGVIALIICFVVIFICQHLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EEB3</accession>
    <name>A0A174EEB3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division inhibitor MinD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">minD_3</name>
        <name evidence="2" type="ORF">ERS852478_02584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380763.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36194">
        <property type="protein sequence ID" value="CUO36194"/>
        <property type="gene ID" value="ERS852478_02584"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014433">
        <property type="entry name" value="CooC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005647">
        <property type="entry name" value="CooC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO36194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="254" mass="27871" checksum="6037540C9712ECC2" modified="2016-09-07" version="1">MKIAVTGKGGVGKTTFAATLARLYAAEGRPVLAADVDPDANLGLALGFDEETLDSIVPISKMRKLVEERTGATAGNQFYHLNPKVDDIPEKYGKVCNGVRLLVLGTVETGGGGCVCPEHVMLKRIINNLVLRREDVVILDMEAGLEHLGRGTTEGVDAFIVVIEPGARSVQTYKNVKRLAKDLGVSQVKVVANKVRNEDDENFIRERIPQEDLLGMIHYNTEVIDADRQGKSPYDFSKTVTNEIIKIKEKIDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EFJ4</accession>
    <name>A0A174EFJ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Purine nucleoside phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852478_02595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200796.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36483">
        <property type="protein sequence ID" value="CUO36483"/>
        <property type="gene ID" value="ERS852478_02595"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="PTHR30616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00726">
        <property type="entry name" value="TIGR00726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO36483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="283" mass="32141" checksum="A91FD05F9055C222" modified="2016-09-07" version="1">MKIKWNSEQIPKMNVKNNKDVTFLTYPAYEEMNWLVHGFSTRFGGVSRGIYSSMNLSFTRGDEESCVKENYRRISEAMGFDMNSIVTSDQTHTNNVRKVTEKDRGKGIVIPRDYTDTDGMITNVPGLVLATFYADCVPLYFADPANHAIGLSHSGWRGTVQKIGAVTIEKMSEEYGSNPKDLKVAIGPSICQECYEVSEDVIEEFEKVFDKKYRNKLFYRKENGKYQLNLWMANKIIFLEAGIPEENISMPNLCTCCNPEFLFSHRASHGKRGNLGAFLGIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EHY7</accession>
    <name>A0A174EHY7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CO-methylating acetyl-CoA synthase</fullName>
            <ecNumber evidence="1">2.3.1.169</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852478_02582</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.169" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36146">
        <property type="protein sequence ID" value="CUO36146"/>
        <property type="gene ID" value="ERS852478_02582"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018492">
        <property type="term" value="F:carbon-monoxide dehydrogenase (acceptor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043884">
        <property type="term" value="F:CO-methylating acetyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045822">
        <property type="entry name" value="ACS_CODH_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004461">
        <property type="entry name" value="CO_DH/Ac-CoA_synth_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038571">
        <property type="entry name" value="CO_DH/Ac-CoA_synth_bsu_3_sf"/>
    </dbReference>
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        <property type="entry name" value="CODH_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42281">
        <property type="entry name" value="PTHR42281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19436">
        <property type="entry name" value="ACS_CODH_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03598">
        <property type="entry name" value="CdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18537">
        <property type="entry name" value="CODH_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00316">
        <property type="entry name" value="cdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CODH_A_N" evidence="8">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="ACS_CODH_B_C" evidence="9">
        <location>
            <begin position="464"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO36146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="708" mass="77476" checksum="153AE4A59AC4C062" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F391</accession>
    <name>A0A174F391_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UGMP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ydiC</name>
        <name evidence="3" type="ORF">ERS852478_02834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200953.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000061.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44524">
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        <property type="gene ID" value="ERS852478_02834"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    </dbReference>
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        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PTHR11735:SF11"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO44524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="242" mass="26721" checksum="7801A7BC406912A2" modified="2016-09-07" version="1">MKILALDSSGIVASVAVVEDDTLLAEYTVNYKKTHSQTLLPMLDEIVKMTELELESVDAIAVAAGPGSFTGLRIGSATAKGLGLALKKPLVAVPTVDALAYNLYDAQGLICPIMDARRKQVYTGIYRFEEHQLMTLREQWAAPIEELLEELNQRGEMVTFLGDGVPVFRELIAEKLQVPYSFAPAHVNKQRAAAVAALGSIYYKEGRTETAMEHIPEYLRVSQAERERAEREKEQKPAGTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F8S3</accession>
    <name>A0A174F8S3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TnpV protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_03413</name>
        <name evidence="1" type="ORF">ERS852478_02899</name>
        <name evidence="2" type="ORF">GT712_17995</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000055">
        <property type="protein sequence ID" value="MZS90888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705146.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46514">
        <property type="protein sequence ID" value="CUO46514"/>
        <property type="gene ID" value="ERS852478_02899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026989">
        <property type="entry name" value="TnpV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14198">
        <property type="entry name" value="TnpV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO46514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS90888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX67136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="124" mass="14992" checksum="FA883D63B2F07F2B" modified="2016-09-07" version="1">MKKQIYDEKNGLSYTLHGDYYLPDLEINEEEPTYGKYGIMRKQFLKEHRSARYQYLVLTGKLTEQLNQVDKEAREKVEMLMEQMVEQWGVTEELKMHEQMEWVRRKDNIQAIAEEIALKEIIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FDI3</accession>
    <name>A0A174FDI3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IS66 Orf2 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058750.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPF010000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46729">
        <property type="protein sequence ID" value="CUO46729"/>
        <property type="gene ID" value="ERS852478_02908"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008878">
        <property type="entry name" value="Transposase_IS66_Orf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36455">
        <property type="entry name" value="PTHR36455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05717">
        <property type="entry name" value="TnpB_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO46729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="112" mass="12973" checksum="97B2369239FFBA08" modified="2016-09-07" version="1">MLADISSVDAIYIVCGRTDMRKSIDGLCAIIQEQFSMEIDHALFLFCGRRCDRIKAILKEPDGIVMIYKRLTAQGSYRWPRNKSEVRNLTWREFDWLMSGIDIEQPKAIKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FEZ5</accession>
    <name>A0A174FEZ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02929</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705163.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47249">
        <property type="protein sequence ID" value="CUO47249"/>
        <property type="gene ID" value="ERS852478_02929"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="3">
        <location>
            <begin position="194"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO47249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="366" mass="39503" checksum="68F61F6750DA43E6" modified="2016-09-07" version="1">MNKKPNEKPIFLYIVIGILTVAVIALAAVSFLSLNHLVTLQQKVQTLSKTVEEISTDANTLISQADQLDELREQESSVKAATGETSPAQSESAEPSSESEQQNGTLSPSSNNTFTDNTDSSMDNLLKQVQSLLPADNGTWSVYVCNLPKDSEGMINDTPMQAASLIKLYIMGAVYENYDTLSQSHNGDEIDSNISAMITVSDNDAANTLVNWLGNGDNSAGMAKVNGFCQEHGFTSTQMNRLLLAGKENGDNYTSVKDCGTFLKQIYQTVNGTLPASTLPNADAMYYHLKMQQRKNKIPAQLPEGVGTANKTGELDTVENDAAIIYDTAKGIDLVVCFMSQNLTDTGAAQSTIAADARAIYGYYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FGS9</accession>
    <name>A0A174FGS9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PF03932 family protein CutC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">cutC</name>
        <name evidence="3" type="ORF">ERS852478_02949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48046">
        <property type="protein sequence ID" value="CUO48046"/>
        <property type="gene ID" value="ERS852478_02949"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="Cu_homeostasis_CutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="PTHR12598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="SSF110395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO48046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="248" mass="27564" checksum="8C71FBAEFA92B5B7" modified="2016-09-07" version="1">MKEYILEACVDSVESAMAAVEGGADRLELCGNLIIGGTTPGPWLFDEIRKRSDIRIHALIRPRFGDFCYTDAEFSMIKHAVEDFRKMGAEGVVFGVLKPDGTLNMEQMKELMEAAGDMSVTLHRAFDVCVDPIETMEQAISLGINTILTSGQRNVCLQGVDLLRELEEKSRGRITIQAGSGVGASVIRQLYPLTGIKAYHMTGKRVIDSEMQFRKDGVNMGLPMLSEYEIWRTDVDNIRAAKKVLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FGV4</accession>
    <name>A0A174FGV4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yadH</name>
        <name evidence="8" type="ORF">ERS852478_02943</name>
        <name evidence="9" type="ORF">ERS852523_01508</name>
        <name evidence="11" type="ORF">GT712_01910</name>
        <name evidence="10" type="ORF">GT728_07255</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">2789STDY5834863</strain>
            <strain evidence="9 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">BIOML-A1</strain>
            <strain evidence="11 14">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO47899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP40336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000013">
        <property type="protein sequence ID" value="MZL33002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706312.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000028_gene220"/>
    <dbReference type="EnsemblBacteria" id="CUO47899">
        <property type="protein sequence ID" value="CUO47899"/>
        <property type="gene ID" value="ERS852478_02943"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP40336">
        <property type="protein sequence ID" value="CUP40336"/>
        <property type="gene ID" value="ERS852523_01508"/>
    </dbReference>
    <dbReference type="GeneID" id="66493644"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="3"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO47899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP40336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL33002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS87879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="243" mass="26949" checksum="C015433B32738A92" modified="2016-09-07" version="1">MGIITILWEKWVEFRRDFYKITLAAMIAPLMYLIVFGMGIQTTSHGQPYLNFLIPGVVSLTTMNGSFNAIAQNLNVQRLYEKAFDQVMISPTPLWQFIAGQIIGGSLRGLYAGGIILLLTAPIETGLIFNGWSFLVMFLNGAVFSAIGVVVSFLAKNHADVPRFSNYIIMPMAYLCNTFFSTEKLPGFVGKFVSALPLSQTSHLMRSISSGEAVNYTGIGILLLYLLVFTVAASWFIYKKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FLT1</accession>
    <name>A0A174FLT1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201084.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50691">
        <property type="protein sequence ID" value="CUO50691"/>
        <property type="gene ID" value="ERS852478_03031"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50324CZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO50691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="138" mass="14933" checksum="D20FF36D6D98A5B4" modified="2016-09-07" version="1">MSIIENVQPAVKKETGKVAAITGIGLILMWIVFGVLHAFMPQKVPFDYTVFLGGAVGGCVAVLNFFFMGLAVQKAAAATDEDTARMRIKASYSQRMLIQMFWVILAIVAPCFHFVAGIVPLLFPGTGIKIAGIFHTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FPS1</accession>
    <name>A0A174FPS1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable sensor-like histidine kinase YehU</fullName>
            <ecNumber evidence="6">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yehU_8</name>
        <name evidence="6" type="ORF">ERS852478_03010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577762.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50145">
        <property type="protein sequence ID" value="CUO50145"/>
        <property type="gene ID" value="ERS852478_03010"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="354"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO50145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="483" mass="55391" checksum="33D9F6ECA9153338" modified="2016-09-07" version="1">MKQKQEKLETKMKWMLLSTMIPMTILIIVLLVFFWHYTNEYNQLSNNLAVSSEYNANYRNSNNDMSFKDEVDMDIYYVTIGRKGKDGLPTEQVDKAISTVESLKKTTSKKESLRSLKYLTNYLENLKKRMNQLLEIKNYQERQEFVANNTEILTTLFEKEMQNYIYQEATELVQIESQLAGNVRLTIITMCAAILVATAILLRRSFRLTYSITKPISEILHNIKKVGKGEYKTINVVSADSVEIQELDAGTRKMAGRIEGLLENVRKEQEVQHMTELQLIQAQVNPHFLYNTLDTIVWLVEGGMQQDAVDMITSLSVFFRTSLSKGKDIIPLSEEKRHTLSYLEIQQSRYRDIMEFEINIPPELDEVMVPKLTLQPLAENALYHGIKNKRGKGKILIEGFNLGDDMMLRVTDNGQGMTPERLYEVQEAIRTGERAGFGLAAVSERIALYYGPGYGLKISSTEGEGTVMEVYMAKKINLDNNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FQS1</accession>
    <name>A0A174FQS1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PrcB_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_00774</name>
        <name evidence="2" type="ORF">ERS852478_03067</name>
        <name evidence="3" type="ORF">ERS852523_03122</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO52071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000040">
        <property type="protein sequence ID" value="CUP87857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000020">
        <property type="protein sequence ID" value="VUX63083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000091_gene2612"/>
    <dbReference type="EnsemblBacteria" id="CUO52071">
        <property type="protein sequence ID" value="CUO52071"/>
        <property type="gene ID" value="ERS852478_03067"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP87857">
        <property type="protein sequence ID" value="CUP87857"/>
        <property type="gene ID" value="ERS852523_03122"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032U0T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025748">
        <property type="entry name" value="PrcB_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14343">
        <property type="entry name" value="PrcB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PrcB_C" evidence="1">
        <location>
            <begin position="71"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO52071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP87857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX63083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="140" mass="15824" checksum="1AD189A72247663F" modified="2016-09-07" version="1">MGKRTGGLLCVLLLALLPAGCQFIRIEEGERTPLEYTIVKQEEIPEEISELMEQKKKKVFQMTYQVGDIRYLMKGYGEQLTGGYSIQVEEVSESENAVFCKTRLIGPEKADAGSEPSYPCIVLKIRETEKPIEFLGFIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FTB7</accession>
    <name>A0A174FTB7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA strand transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mobA_3</name>
        <name evidence="6" type="ORF">ERS852478_03109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MobA/MobL family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002595105.1">
        <property type="nucleotide sequence ID" value="NZ_JAAINB010000067.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53512">
        <property type="protein sequence ID" value="CUO53512"/>
        <property type="gene ID" value="ERS852478_03109"/>
    </dbReference>
    <dbReference type="GeneID" id="57969715"/>
    <dbReference type="GeneID" id="64114876"/>
    <dbReference type="GeneID" id="66495705"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005053">
        <property type="entry name" value="MobA_MobL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03389">
        <property type="entry name" value="MobA_MobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0184">Conjugation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MobA_MobL" evidence="5">
        <location>
            <begin position="17"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="479"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="247"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO53512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="524" mass="60926" checksum="0F43BA7007D5110C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FU04</accession>
    <name>A0A174FU04_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03118</name>
        <name evidence="4" type="ORF">ERS852523_04370</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
            <strain evidence="4 6">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000109">
        <property type="protein sequence ID" value="CUQ20461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002593556.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITF010000098.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000013_gene3189"/>
    <dbReference type="EnsemblBacteria" id="CUO53744">
        <property type="protein sequence ID" value="CUO53744"/>
        <property type="gene ID" value="ERS852478_03118"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ20461">
        <property type="protein sequence ID" value="CUQ20461"/>
        <property type="gene ID" value="ERS852523_04370"/>
    </dbReference>
    <dbReference type="GeneID" id="61432593"/>
    <dbReference type="GeneID" id="66882986"/>
    <dbReference type="eggNOG" id="COG3655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO53744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUQ20461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="90" mass="10280" checksum="D751D85D84380833" modified="2016-09-07" version="1">MHISYKPLWHTLLERDMRKEDLRLAAGMTTNMIANMSKEGKHISMDTLARICETLNCEITDVIELVPDEPASTGGKEHERIETKNNGKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FZ54</accession>
    <name>A0A174FZ54_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type 1 glutamine amidotransferase-like domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Uncharacterized peptidase Lmo0363</fullName>
            <ecNumber evidence="4">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_03135</name>
        <name evidence="5" type="ORF">GT712_01970</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S51 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO54208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005930833.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54208">
        <property type="protein sequence ID" value="CUO54208"/>
        <property type="gene ID" value="ERS852478_03135"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005320">
        <property type="entry name" value="Peptidase_S51"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03575">
        <property type="entry name" value="Peptidase_S51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO54208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS87888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="205" mass="22867" checksum="4A00D1ECA2946F79" modified="2016-09-07" version="1">MNGKHLFLTSAGLTDKMKEKFFDIIGKCPKDVKVLYIPTAGIETDGARESLAICFHELFLMGIQYENILVYNLELILSKDYQRTYSSYVTTPFMLTRLLTFEELNQFDAVFVSGGDVSVLCREMSRTGFDRILNNAIKNGLIYVGISAGSMYAAGNLTDGLHIIDNPIIPHWNGSETTVLPNGKDEIKLADGKAVYVEDNYMSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G1F3</accession>
    <name>A0A174G1F3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein YxdL</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">macB_7</name>
        <name evidence="6" type="synonym">yxdL_3</name>
        <name evidence="6" type="ORF">BWLFYP14_00682</name>
        <name evidence="5" type="ORF">ERS852478_03145</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO54660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000015">
        <property type="protein sequence ID" value="VUX62933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201198.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000091.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54660">
        <property type="protein sequence ID" value="CUO54660"/>
        <property type="gene ID" value="ERS852478_03145"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO54660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX62933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="255" mass="27897" checksum="4B1A5A340E8451A5" modified="2016-09-07" version="1">MKEILKLDHIQKYYGNGGNVTKAIQDISFSVQEGEFVGIMGASGSGKTTLLNCISTIDTVSAGHIYLDGTDVTEINEKQIARFRRENLGFVFQDFNLLDTLTISENIALALTINKIPAGEIDGRVREMAGKLNITDILDKYPYQVSGGQKQRCACARAIINQPKLILADEPTGALDSHSSQALLSTIQSINESLDATILMVTHDAFSASYANRILFLRDGAIFTEILKGSDSRRVFFEKILNVLTMMGGGVNDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G9J0</accession>
    <name>A0A174G9J0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diacylglycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.107</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">YegS/Rv2252/BmrU family lipid kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dagK</name>
        <name evidence="6" type="ORF">BWLFYP14_00312</name>
        <name evidence="3" type="ORF">ERS852478_03225</name>
        <name evidence="5" type="ORF">GT712_16725</name>
        <name evidence="4" type="ORF">GT728_05000</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">BIOML-A1</strain>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the diacylglycerol/lipid kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000045">
        <property type="protein sequence ID" value="MZS90657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707346.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57519">
        <property type="protein sequence ID" value="CUO57519"/>
        <property type="gene ID" value="ERS852478_03225"/>
    </dbReference>
    <dbReference type="GeneID" id="66496184"/>
    <dbReference type="eggNOG" id="COG1597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO57519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX67467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="316" mass="35445" checksum="F488F37545BF8A10" modified="2016-09-07" version="1">MNKKMLFVFNPKAGKGKIKTNLLDIVDIFNKGGYEVIIYSTQKPKDAYEKAKEYESKVDLIVCSGGDGTLDEVVTGVMEKKSSIPIGYIPAGSTNDFANSLFMPKSMTDAASMIMEEKLYHCDIGRFNNQSFTYIAAFGLFTDVAYQTDQDLKNILGHVAYLLEGVKRLFDIKSYHMRIESEELTVEDDFIFGMITNSRSVGGFKNLTGKNVDMNDGLFEVTMITRPKNPLELQEIMTAMLTAEDNTDLIHSFKSARVTITSEEPVPWTLDGEYGGSHTQIEIENCHEALNLYLKSTKNEETRSIGISPLINKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GGU0</accession>
    <name>A0A174GGU0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Solvent efflux pump srpABC operon corepressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">srpR</name>
        <name evidence="3" type="ORF">ERS852478_03356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201316.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61782">
        <property type="protein sequence ID" value="CUO61782"/>
        <property type="gene ID" value="ERS852478_03356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO61782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="236" mass="27013" checksum="75DBF52524681914" modified="2016-09-07" version="1">MEKIEGTSPTRVRQAQQRRDRIINASMKLFQEKCVEDTSMEEVAKRAGVGAATVYRYFSSKIELVIETAEVYWEKASEKYLGELETGNMPNIADAKSEATLKMDGIESSGYDQLRKILNVFCRIFLEQKPFLKFLHEFDVFVKKYNVSEEHLADYENGILKLKPYVTIALEKGLVDKSLSFNCSVDEMYFSLTHTLLALMEKLAVGGDILSSDQNVESEKQIRIIIELLLRGIRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GI31</accession>
    <name>A0A174GI31_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacterial SH3 domain protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein with a bacterial SH3 domain homologue</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_00758</name>
        <name evidence="3" type="ORF">ERS852478_03307</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000019">
        <property type="protein sequence ID" value="VUX63010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993697.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000138.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60095">
        <property type="protein sequence ID" value="CUO60095"/>
        <property type="gene ID" value="ERS852478_03307"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033IHB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252860" evidence="1">
        <location>
            <begin position="31"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="46"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO60095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX63010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="107" mass="11699" checksum="DE0DFBBED90B7674" modified="2016-09-07" version="1">MKYMRKNSFVVCLVISAILLTSSFAMPVLAAENTGIETSSVTRSVPGYYKCTGSDVNIRSGPGTQYTIVGTLNYGTKVYVYSISNGWAKISLGGIYRYVSADYLREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GKA5</accession>
    <name>A0A174GKA5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase ytpA</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ytpA</name>
        <name evidence="2" type="ORF">ERS852478_03358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201319.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61837">
        <property type="protein sequence ID" value="CUO61837"/>
        <property type="gene ID" value="ERS852478_03358"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="57"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO61837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="331" mass="38266" checksum="90E464660A03C344" modified="2016-09-07" version="1">MELIHENEYLYKMNDEIEPYLATHRQEGYVPSAEDHLHQKDTGIVGKIHVQRYLAEKPKGVIIISHGFTEAAPKYDEMIYYFLKAGYHVYMPEHMGHGQSYRLTADPSLVHIDTWKRYVRDFLKICHVIKKTYPELPLVLFAHSMGGAIGTIAAAWEPQLFQKIILNSPMLRPLTGNVPWPLVIAIAQTKCLLGKKEDYVAGQKPYDGSETFETSGCTSRPRFEKYNELRKENKKFQVSAASYGWLLASVKMSWYIKYCGWKKLSAPVLLFQAEKDDFVSVNALRKFAEKINHRGITSCEYVYLPGTRHETYCSDDRTMQVYLDKIMKFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GSP6</accession>
    <name>A0A174GSP6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate diacid transcriptional activator CdaR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Purine catabolism regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pucR_3</name>
        <name evidence="6" type="ORF">BWLFYP14_02261</name>
        <name evidence="4" type="ORF">ERS852478_03427</name>
        <name evidence="5" type="ORF">GT712_16290</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZS90577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381269.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000094.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64056">
        <property type="protein sequence ID" value="CUO64056"/>
        <property type="gene ID" value="ERS852478_03427"/>
    </dbReference>
    <dbReference type="GeneID" id="66495127"/>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="284"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="452"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO64056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="522" mass="60397" checksum="1128943487646526" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GSY2</accession>
    <name>A0A174GSY2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bile acid transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Bile acid:sodium symporter family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Sodium Bile acid symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_02265</name>
        <name evidence="3" type="ORF">ERS852478_03431</name>
        <name evidence="5" type="ORF">GT712_16285</name>
        <name evidence="4" type="ORF">GT728_10870</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">BIOML-A1</strain>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000024">
        <property type="protein sequence ID" value="MZL33687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000042">
        <property type="protein sequence ID" value="MZS90576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704363.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64156">
        <property type="protein sequence ID" value="CUO64156"/>
        <property type="gene ID" value="ERS852478_03431"/>
    </dbReference>
    <dbReference type="GeneID" id="66495126"/>
    <dbReference type="eggNOG" id="COG0385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="PTHR10361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO64156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="327" mass="34566" checksum="ECE0097F3B2C8DEA" modified="2016-09-07" version="1">MENILKKIGKISSFASRYIGIIIIAFSCLAFFWRDGFAWMTNYTSVFLGVIMFGMGLTIRLEDFRAIFSRPKEVIIGAVAQYTIMPVVAWVLCKVMNLPADLALGVILVGCCPGGTASNVITYIAGGDVALSVGMTIVSTLAAPVMTPFLVYILAGAWVEVSFWAMVLSVVKVILVPVLLGILLRTLAGDHVDKVSDVMPLISVVAIVMIIGGIVAINAEKILSCGVLVLGVVAIHNFCGMMLGLLAAKIFHVEYTRATAIAIEVGMQNSGLAVSLAAANFVANPLATLPGAIFSVWHNIAGSIFAGIRRSGVENRTRTGENGVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GUL0</accession>
    <name>A0A174GUL0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02279</name>
        <name evidence="2" type="ORF">ERS852478_03445</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993834.1">
        <property type="nucleotide sequence ID" value="NZ_WWVC01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64499">
        <property type="protein sequence ID" value="CUO64499"/>
        <property type="gene ID" value="ERS852478_03445"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO64499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="231" mass="26862" checksum="5E84E5CF9E060799" modified="2016-09-07" version="1">MRPINKGESPYKKINEYKDALPYLERRIGMYCSYCEFSIPHVPEVEHVVSKSKGGDLTDWNNLNLGCKYCNTRKKAQTMPENKKNYLWPDEDNTAIAYSYINGIPKVNEELLIKLDSTGDYLKRARNTYNLVGLGNLPMGKDRDRRFGQRNTAYQKALNSLEHWNHMKDLSKEYQNDMKNQIIMTALGDGFFSIWMEVFCDEPEIRLALIEAFPGTNLNYYDEKGCVKEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H0P3</accession>
    <name>A0A174H0P3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060664.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000204.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66828">
        <property type="protein sequence ID" value="CUO66828"/>
        <property type="gene ID" value="ERS852478_03517"/>
    </dbReference>
    <dbReference type="GeneID" id="66495016"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="41"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO66828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="99" mass="11593" checksum="7F62B73163CF5EB6" modified="2016-09-07" version="1">MQENMKEYLTEKEAREKRLEVYTEKIQEKVLSRSSETIRQLVEERHRQKMTQQEIADITGIKPSNMARFESGGRVPTLVVLEKYANALGKHIEIKICDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H1N7</accession>
    <name>A0A174H1N7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66705">
        <property type="protein sequence ID" value="CUO66705"/>
        <property type="gene ID" value="ERS852478_03512"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO66705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="53" mass="6122" checksum="20A7C3A585585534" modified="2016-09-07" version="1">MIKISEILEIGSNKKYIDNLIKECKKENIIPFIGAGMSVPIYELWGDFFNRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H614</accession>
    <name>A0A174H614_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FtsX-like permease family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_03580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO68857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68857">
        <property type="protein sequence ID" value="CUO68857"/>
        <property type="gene ID" value="ERS852478_03580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="611"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="671"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="87"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO68857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="742" mass="85372" checksum="B47B8F3330146CEE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HDP7</accession>
    <name>A0A174HDP7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">saeR</name>
        <name evidence="11" type="ORF">ERS852478_03670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201482.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71456">
        <property type="protein sequence ID" value="CUO71456"/>
        <property type="gene ID" value="ERS852478_03670"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="13"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="133"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="133"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO71456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="230" mass="26316" checksum="EE795C107945BF7C" modified="2016-09-07" version="1">MWYNGAGGDFLTHLLVVDDEVSILELIKNSLGKDGYLITVCQNADDVDIKKLHFYDLILLDVMMPGTDGFEFCKQIRNMVDCPILFLTAKTLEEDILFGLGIGADDYITKPFRIQELRARVAAHLRREKREHHSTLSFEPDIRFDLSAKVLYVSEQPVPLTKSEYSICEYLAKNRGQVFTKEQIYEAVFGFDGIGDNSTISTHIKNIRTKLEHFKISPISTVWGIGYKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HF00</accession>
    <name>A0A174HF00_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4179 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03737</name>
        <name evidence="3" type="ORF">GT712_18715</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000046">
        <property type="protein sequence ID" value="CUO73424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000063">
        <property type="protein sequence ID" value="MZS91014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059821.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73424">
        <property type="protein sequence ID" value="CUO73424"/>
        <property type="gene ID" value="ERS852478_03737"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030HYG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025436">
        <property type="entry name" value="DUF4179"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13786">
        <property type="entry name" value="DUF4179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4179" evidence="1">
        <location>
            <begin position="37"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO73424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS91014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="376" mass="42812" checksum="3D4660AFDA3E11BB" modified="2016-09-07" version="1">MEKGFKTLELLGDLDDKYIYEASRPWKKQHRFFHIQRSWKTAVAGIILLIMVGCTLRYQEDVKAALQRVTSWIGQALGIKNGDTDSYTNVVGKSISRDGITITLNEIVMDSKNLWIAYSDSEDSDADMKDAVEDKLLYTEVCINGQKIQQGLGQRTVNAFSENPITVEDFTIGEEVNTEGTVNIEFKVWPIAMDDADTWENVQKIQADTEPYTFKLATSKEELEKNTVDLNLNQNIKMDSNVLNLTEFRWNPFESTIYGMYHGTVYIDSDYYLLGTDDQGNKICYQETGRNGQETMFRQTIGLYPGYEEISPEANTITLQLYEVKNDTAHQVSEEKMDKDSSDDIYEESTTYVYDGGESPIDSAIPIGDNFTIQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HNK7</accession>
    <name>A0A174HNK7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arsenate reductase</fullName>
            <ecNumber evidence="5">1.20.4.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">arsC</name>
        <name evidence="5" type="ORF">ERS852478_03783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000049">
        <property type="protein sequence ID" value="CUO74738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201524.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74738">
        <property type="protein sequence ID" value="CUO74738"/>
        <property type="gene ID" value="ERS852478_03783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="4">
        <location>
            <begin position="4"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO74738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="135" mass="15087" checksum="BAC9B5EEC3C7F196" modified="2016-09-07" version="1">MNKKKVAFICVHNSCRSQIAEALGKHLASDIFESYSAGTETKPQINQDAVRIMKEIYGIDMEANGQYSKLITDIPDVDIAISMGCNVGCPFIGRAFDDNWGLDDPTGKSDDDFKTVIQRIEENIIELKKRLSENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HR75</accession>
    <name>A0A174HR75_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000053">
        <property type="protein sequence ID" value="CUO75827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75827">
        <property type="protein sequence ID" value="CUO75827"/>
        <property type="gene ID" value="ERS852478_03814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO75827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="58" mass="6728" checksum="0C3B6C33BC1D6AA4" modified="2016-09-07" version="1">MMYRTELVEGITVENVTEKINAKIEEMEKESYRLVTMSFWGTERAVLVFKKGLKGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KPN8</accession>
    <name>A0A174KPN8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protochlorophyllide reductase iron-sulfur ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00719</name>
        <name evidence="3" type="ORF">ERS852523_00625</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP12406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055149525.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65593">
        <property type="protein sequence ID" value="CUN65593"/>
        <property type="gene ID" value="ERS852478_00719"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12406">
        <property type="protein sequence ID" value="CUP12406"/>
        <property type="gene ID" value="ERS852523_00625"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014433">
        <property type="entry name" value="CooC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005647">
        <property type="entry name" value="CooC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN65593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP12406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="249" mass="27849" checksum="6066334C2232B1B2" modified="2016-09-07" version="1">MKIAVCGKGGCGKSTVTSLLAKALARRGKEILVIDSDESNYGLHRQLGMKLPRDFTDYFGGKQNVLNDMMLSKFTHQFFEETWTIDDIPEDYYSLKDGVKLMSSGKIHQANEGCSCAMGTVMTQFIQNLRLKEDQFALMDMEAGIEHFGRGIDNGVDLILIIIDPSYESLQLSKKIGELSESIRKPFYYVLNKVTKENQEMMYEAVWNSSRVAVSLGADPSIMGEGLMGKELSEKPDAIENLTEFLLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KRM8</accession>
    <name>A0A174KRM8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Leucine/isoleucine/valine transporter permease subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BWLFYP14_01814</name>
        <name evidence="7" type="ORF">ERS852478_00694</name>
        <name evidence="8" type="ORF">ERS852523_00650</name>
        <name evidence="9" type="ORF">GT712_03220</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
            <strain evidence="8 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP13096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993609.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000015_gene3706"/>
    <dbReference type="EnsemblBacteria" id="CUN64843">
        <property type="protein sequence ID" value="CUN64843"/>
        <property type="gene ID" value="ERS852478_00694"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13096">
        <property type="protein sequence ID" value="CUP13096"/>
        <property type="gene ID" value="ERS852523_00650"/>
    </dbReference>
    <dbReference type="GeneID" id="66493471"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN64843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP13096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS88123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX65054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="351" mass="37847" checksum="900C4E0FFDB90964" modified="2016-09-07" version="1">MEKKKLNKTTKSNLITYGMVLAAYLIVQGMIAGNLLSNLMQGLLVPLCVYIILALSLNLTVGILGELSLGHAGFMCIGAFTSAAFTKATMDTFTNAGLRFFVALIIGAVCAGIFGFLIGIPVLRLKGDYLAIVTLAFGEIIKNIINVLYVGIDSNGIHFSMKDQMSLGMEPGGKMIISGAMGITGTPRQSTFTIGVILILVTLFVVLNLINSRDGRAIMAIRDNRIAAESIGIDITKYKLKAFAISAALAGIGGVLYAHNLATLTALPKNFGYNMSIMFLVFVVLGGIGNMRGSIIAAVILNLLPELLRGLSDYRMLFYAIVLIVMMLINWAPKAIEMRERLFSKFKKKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KX07</accession>
    <name>A0A174KX07_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="14">ATP-PRT</shortName>
            <shortName evidence="14">ATP-PRTase</shortName>
            <ecNumber evidence="5 14">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">hisG</name>
        <name evidence="20" type="ORF">BWLFYP14_02517</name>
        <name evidence="16" type="ORF">ERS852478_00016</name>
        <name evidence="17" type="ORF">ERS852523_00753</name>
        <name evidence="19" type="ORF">GT712_07820</name>
        <name evidence="18" type="ORF">GT728_12710</name>
    </gene>
    <organism evidence="17 22">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 21 22" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 21">2789STDY5834863</strain>
            <strain evidence="17 22">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="18 24 25" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 25">BIOML-A1</strain>
            <strain evidence="19 24">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="20 23" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heteromultimer composed of HisG and HisZ subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">Lacks the C-terminal regulatory region which is replaced by HisZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the ATP phosphoribosyltransferase family. Short subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5 14"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP16503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000031">
        <property type="protein sequence ID" value="MZL34038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008702990.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1380"/>
    <dbReference type="EnsemblBacteria" id="CUN41163">
        <property type="protein sequence ID" value="CUN41163"/>
        <property type="gene ID" value="ERS852478_00016"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16503">
        <property type="protein sequence ID" value="CUP16503"/>
        <property type="gene ID" value="ERS852523_00753"/>
    </dbReference>
    <dbReference type="GeneID" id="66492915"/>
    <dbReference type="eggNOG" id="COG0040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13595">
        <property type="entry name" value="PBP2_HisGs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01018">
        <property type="entry name" value="HisG_Short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024893">
        <property type="entry name" value="ATP_PRibTrfase_HisG_short"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 14" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="15">
        <location>
            <begin position="56"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUN41163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUP16503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MZL34038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MZS88979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VUX66145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="215" mass="24435" checksum="0C2899EDA0F43A71" modified="2016-09-07" version="1">MRYLTVALTKGRLANKTMEMFEKAGITCEEMKDKDSRKLIFTNEELKMKFFLAKGPDVPTYVEYGAADIGIVGKDTILEEGRKLYEVMDLGFGKCKMCVCGPESAREVLENNQLIRVATKYPNIAKDYFFNRKHQTVDLIKLNGSIELAPIVGLSEVIVDIVETGSTLKENGLKVLEEVCPLSARMVVNQVSMKMENERIRKLIEDLRRVLQEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LTC8</accession>
    <name>A0A174LTC8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase DDE domain protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Transposase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02488</name>
        <name evidence="3" type="ORF">ERS852478_02445</name>
        <name evidence="4" type="ORF">ERS852523_01057</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO31341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP26026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000032_gene410"/>
    <dbReference type="EnsemblBacteria" id="CUO31341">
        <property type="protein sequence ID" value="CUO31341"/>
        <property type="gene ID" value="ERS852478_02445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26026">
        <property type="protein sequence ID" value="CUP26026"/>
        <property type="gene ID" value="ERS852523_01057"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO31341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP26026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="112" mass="13131" checksum="ABB85B6B234A9392" modified="2016-09-07" version="1">MISEGQRNDINYAIPLLDQIEINGSNVLADRGYDSNKLLDYVYARGGEPTIPSRKGAKFERHCDWWLYKERHLVEKYFLKLKAFRRIATRYDKLAATYLGFICIASILIWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MJ83</accession>
    <name>A0A174MJ83_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SpoVA protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">SpoVA/SpoVAEb family sporulation membrane protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Stage V sporulation protein AE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_00245</name>
        <name evidence="2" type="ORF">ERS852478_01647</name>
        <name evidence="3" type="ORF">ERS852523_01305</name>
        <name evidence="5" type="ORF">GT712_09040</name>
        <name evidence="4" type="ORF">GT728_04640</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707235.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000057_gene2529"/>
    <dbReference type="EnsemblBacteria" id="CUO02233">
        <property type="protein sequence ID" value="CUO02233"/>
        <property type="gene ID" value="ERS852478_01647"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33995">
        <property type="protein sequence ID" value="CUP33995"/>
        <property type="gene ID" value="ERS852523_01305"/>
    </dbReference>
    <dbReference type="GeneID" id="66496110"/>
    <dbReference type="eggNOG" id="ENOG50315MJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005562">
        <property type="entry name" value="SpoVA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38450">
        <property type="entry name" value="PTHR38450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03862">
        <property type="entry name" value="SpoVAC_SpoVAEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO02233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP33995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX67404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="118" mass="12503" checksum="46713121170A0F17" modified="2016-09-07" version="1">MDYFNAFWTGGLICALVQILLDRTKLMPGRIMVLLVCTGSVLSAVGIYQPFAEFAGAGASVPLLGFGNILWKGMKESIDKNGLIGLFMGGFTACAVGVSAALIFSYLASLIFKPKMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MT23</accession>
    <name>A0A174MT23_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="14">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">secA_3</name>
        <name evidence="14" type="synonym">secA</name>
        <name evidence="20" type="synonym">secA_2</name>
        <name evidence="20" type="ORF">ERS852478_02970</name>
        <name evidence="21" type="ORF">ERS852523_01480</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22 23" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 22">2789STDY5834863</strain>
            <strain evidence="21 23">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="14">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="14"/>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP39574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706273.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000028_gene192"/>
    <dbReference type="EnsemblBacteria" id="CUO48711">
        <property type="protein sequence ID" value="CUO48711"/>
        <property type="gene ID" value="ERS852478_02970"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP39574">
        <property type="protein sequence ID" value="CUP39574"/>
        <property type="gene ID" value="ERS852523_01480"/>
    </dbReference>
    <dbReference type="GeneID" id="66493671"/>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="12 14 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14 15" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="19">
        <location>
            <begin position="1"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="87"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="422"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="810"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CUO48711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CUP39574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="858" mass="98253" checksum="F2E973111435C830" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174PD18</accession>
    <name>A0A174PD18_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">ackA</name>
        <name evidence="10" type="ORF">BWLFYP14_00157</name>
        <name evidence="8" type="ORF">ERS852478_02378</name>
        <name evidence="9" type="ORF">ERS852523_02021</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
            <strain evidence="9 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000019">
        <property type="protein sequence ID" value="CUP55909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1107"/>
    <dbReference type="EnsemblBacteria" id="CUO29280">
        <property type="protein sequence ID" value="CUO29280"/>
        <property type="gene ID" value="ERS852478_02378"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP55909">
        <property type="protein sequence ID" value="CUP55909"/>
        <property type="gene ID" value="ERS852523_02021"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="236"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="312"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="360"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO29280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP55909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX66604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="425" mass="45567" checksum="34A1CD6021F4B2E6" modified="2016-09-07" version="1">MKGKADRNIRRLVSGLWTVFEICCRQNMKMNVLVINCGSSSLKYQLINSDSEAVLAKGLCERIGIDGRLVYQKTGCDKEITEAAMPTHKEAIQMVLDALTNDKTGAIGSLKEVNAVGHRVVHGGEKFAKSVVITDEVISAVEECNDLAPLHNPANLIGIRVCSELMPGVPQVAVFDTAFHQTMPAKAYLYGLPIEYYKNYKVRRYGFHGTSHSFVSKRAVEFLGLDKDNSKVIVCHLGNGSSISAVVNGECVDTTMGLTPLEGVVMGTRSGNIDPAIMEFIAKKENLDIAGMMNVLNKKSGLLGLSGGLSSDFRDLNDAAQSGNEDAANAIDVLCYGIAKFVGGYVAAMNGVDAIVFTAGIGENAIPVREKVVSYLGYLGVTLDKEANGVRGEEIVISTPDSKVKVAVIPTNEELAICRETVALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174PU22</accession>
    <name>A0A174PU22_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 9">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">greA_1</name>
        <name evidence="8 14" type="synonym">greA</name>
        <name evidence="16" type="synonym">greA_2</name>
        <name evidence="16" type="ORF">BWLFYP14_00902</name>
        <name evidence="12" type="ORF">ERS852478_02639</name>
        <name evidence="13" type="ORF">ERS852523_02310</name>
        <name evidence="15" type="ORF">GT712_04985</name>
        <name evidence="14" type="ORF">GT728_06965</name>
    </gene>
    <organism evidence="13 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 17">2789STDY5834863</strain>
            <strain evidence="13 18">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="14 20 21" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 21">BIOML-A1</strain>
            <strain evidence="15 20">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="16 19" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8 9">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the GreA/GreB family.</text>
    </comment>
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        <property type="protein sequence ID" value="CUO38126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ERS852523_02310"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GreA/GreB_C_sf"/>
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        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
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        <location>
            <begin position="85"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO38126.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUP64482.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZL32946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZS88459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VUX63424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="160" mass="18034" checksum="944EFCECF3BC324F" modified="2016-09-07" version="1">MEEKKNLLTYAGLKKLEEELHDLKVVKRKEVAEKIKEAREQGDLSENAEYDAAKDEQRDIEARIEEIEKILKNAEVVVEDEVDLDKISVGCKVKVHDFEFEEDIELKIVGSTEANSLEGKISNESPVGKALIGAHTGDVVEVEMPAGIMKYKVLEIQRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QF73</accession>
    <name>A0A174QF73_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacterial protein of uncharacterized function (DUF951)</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">DUF951 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_00565</name>
        <name evidence="1" type="ORF">ERS852478_02737</name>
        <name evidence="2" type="ORF">ERS852523_02521</name>
        <name evidence="4" type="ORF">GT712_09860</name>
        <name evidence="3" type="ORF">GT728_09595</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
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                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUP70456.1"/>
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    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000019">
        <property type="protein sequence ID" value="MZL33445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZS89367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="VUX62787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_WWVQ01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000058_gene2537"/>
    <dbReference type="EnsemblBacteria" id="CUO41222">
        <property type="protein sequence ID" value="CUO41222"/>
        <property type="gene ID" value="ERS852478_02737"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP70456">
        <property type="protein sequence ID" value="CUP70456"/>
        <property type="gene ID" value="ERS852523_02521"/>
    </dbReference>
    <dbReference type="GeneID" id="66493311"/>
    <dbReference type="eggNOG" id="COG4481">
        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38455">
        <property type="entry name" value="PTHR38455"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF951"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF951_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CUO41222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP70456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX62787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="63" mass="7197" checksum="3112281023B8949C" modified="2016-09-07" version="1">MGLPYEVGDIVTLKKVHPCGSRDWEILRVGADFRLKCTGCGHQIMVPRKMVEKNTKNLIKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174R008</accession>
    <name>A0A174R008_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">macB_5</name>
        <name evidence="5" type="synonym">macB_10</name>
        <name evidence="5" type="ORF">ERS852478_03618</name>
        <name evidence="6" type="ORF">ERS852523_02710</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
            <strain evidence="6 8">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO69927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000030">
        <property type="protein sequence ID" value="CUP75779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006859033.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000056_gene2501"/>
    <dbReference type="EnsemblBacteria" id="CUO69927">
        <property type="protein sequence ID" value="CUO69927"/>
        <property type="gene ID" value="ERS852478_03618"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP75779">
        <property type="protein sequence ID" value="CUP75779"/>
        <property type="gene ID" value="ERS852523_02710"/>
    </dbReference>
    <dbReference type="GeneID" id="61434856"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO69927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP75779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="221" mass="24278" checksum="E8176919775D47D5" modified="2016-09-07" version="1">MSILQTIDLKKYYGTEPNITRALNGVNFTVEQGEFVAVVGTSGSGKSTLLHMMGGLDTPTSGSVIVRGEELAKKNDDELTIFRRRNIGFIFQNYNLVPILNVYENIVLPVELDGDTVDQKFMDEVVYMLALEDKLENMPNNLSGGQQQRVAIARALITKPAIILADEPTGNLDSKTSADVLGLLKHTSGEFNQTIVMITHNNEIAQLADRIVRIEDGKIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174RQR4</accession>
    <name>A0A174RQR4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FCD domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Putative HTH-type transcriptional regulator YdfH</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Uncharacterized HTH-type transcriptional regulator ydfH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ydfH</name>
        <name evidence="5" type="synonym">ydfH_2</name>
        <name evidence="9" type="ORF">BWLFYP14_00777</name>
        <name evidence="5" type="ORF">ERS852478_03064</name>
        <name evidence="6" type="ORF">ERS852523_03125</name>
        <name evidence="8" type="ORF">GT712_15130</name>
        <name evidence="7" type="ORF">GT728_15265</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000040">
        <property type="protein sequence ID" value="CUP87924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000043">
        <property type="protein sequence ID" value="MZL34515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000035">
        <property type="protein sequence ID" value="MZS90365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000020">
        <property type="protein sequence ID" value="VUX63089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707732.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000091_gene2609"/>
    <dbReference type="EnsemblBacteria" id="CUO51999">
        <property type="protein sequence ID" value="CUO51999"/>
        <property type="gene ID" value="ERS852478_03064"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP87924">
        <property type="protein sequence ID" value="CUP87924"/>
        <property type="gene ID" value="ERS852523_03125"/>
    </dbReference>
    <dbReference type="GeneID" id="66493354"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO51999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP87924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL34515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS90365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX63089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="239" mass="27943" checksum="B687C7D013A496D3" modified="2016-09-07" version="1">MTSDFSVNMNEYLPLRDVVFNTLRQAILKGELKPGERLMEIALAERLGVSRTPIREAMRKLEQEGLVVMIPRRGAQVANITEKDLNDVLEVRIALENVAIEKACARMTEEEMRRLWLAAKEFEHTIAEGNLVKLAEADVAFHEVIYQASDNKRLIQVLNNMREQIYRYRVEYLKEGETRDVLVKEHEELTKAIRERDVERAKQLSFQHIENQRMAIMRSIEAEDAERERAEKEKSRGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174RX03</accession>
    <name>A0A174RX03_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">racE</name>
        <name evidence="7" type="synonym">murI</name>
        <name evidence="11" type="ORF">BWLFYP14_00781</name>
        <name evidence="8" type="ORF">ERS852478_03060</name>
        <name evidence="9" type="ORF">ERS852523_03129</name>
        <name evidence="10" type="ORF">GT712_15110</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">2789STDY5834863</strain>
            <strain evidence="9 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000040">
        <property type="protein sequence ID" value="CUP88227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000035">
        <property type="protein sequence ID" value="MZS90361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000020">
        <property type="protein sequence ID" value="VUX63097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707727.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000091_gene2605"/>
    <dbReference type="EnsemblBacteria" id="CUO51897">
        <property type="protein sequence ID" value="CUO51897"/>
        <property type="gene ID" value="ERS852478_03060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP88227">
        <property type="protein sequence ID" value="CUP88227"/>
        <property type="gene ID" value="ERS852523_03129"/>
    </dbReference>
    <dbReference type="GeneID" id="66493350"/>
    <dbReference type="eggNOG" id="COG0796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO51897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP88227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS90361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX63097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="273" mass="30270" checksum="90A42FBB133F9F1C" modified="2016-09-07" version="1">MKIDREAPIGVFDSGVGGLTVAREIMRNLPSEKIVYFGDTARVPYGSKSKETIIRYSRQIIRFLQQQQVKAIVVACNTASAFALDAVRDEFDIPIIGVIEPGAKVAAAQTRNKRVGIIGTVGTVGSGIHAEYLKHLDPEITVFGKACPLFVPLVEEGWLHDPVTDEVAARYLKELQDKQVDTLILGCTHYPLLRSTIRKIMGDGVCLVNPAYETALELGRLLEEKGLAGEGTEKNEFPYRFYVSDLADEFKAFANSILPYDVEMTKKIDIEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174RZI3</accession>
    <name>A0A174RZI3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS30 family transposase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transposase and inactivated derivatives, IS30 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01697</name>
        <name evidence="3" type="ORF">ERS852523_03228</name>
        <name evidence="4" type="ORF">GT712_19990</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000043">
        <property type="protein sequence ID" value="CUP90882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000103">
        <property type="protein sequence ID" value="MZS91236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070100053.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000103.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03961">
        <property type="protein sequence ID" value="CUO03961"/>
        <property type="gene ID" value="ERS852478_01697"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP90882">
        <property type="protein sequence ID" value="CUP90882"/>
        <property type="gene ID" value="ERS852523_03228"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033HZW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="247"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO03961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP90882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS91236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="437" mass="50489" checksum="F54351D50F3EFFB3" modified="2016-09-07" version="1">MKNKGNQKHLTFEQRVDIEKGLTENKSFTEIGRIIGKNPSTISKEVRLHAHTKERPDSGYTHPPCIHRKNCKVTCLCDKMCGIHCKLCRKPSFRCTDICPAYETAECEKLNKPPYVCNGCGKKTHCLMPRKFYSSKYAHDEYRSVLVDCRVGINQTPESIQSMNDLLVPLIKEKHQSIGHIYATHAEELGCSRRTLYSYINDCVFDVRNGDLRRSVRYKKRKKPTQTSAKDRSYRQGHNYENFQNYMKDHPDINVVEMDCVEGMKGESCALLTFTFRNCNLMLMFLLEYQDQECVLEVFVWLETVLGQDAFKKLFPVILTDGGSEFSAREEMEEFCDGSKSTTVFYCDPYSFWQKGACEKNHEYIRYIRPKGSSFADLNDEKVRLMMNHINNEKRDSLNGHSPYELSLLLLDNKLHKALGLKAIAPDDVMLSPKLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174TM20</accession>
    <name>A0A174TM20_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide deformylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03652</name>
        <name evidence="2" type="ORF">ERS852523_03923</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000071">
        <property type="protein sequence ID" value="CUQ09157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381438.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70904">
        <property type="protein sequence ID" value="CUO70904"/>
        <property type="gene ID" value="ERS852478_03652"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ09157">
        <property type="protein sequence ID" value="CUQ09157"/>
        <property type="gene ID" value="ERS852523_03923"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO70904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUQ09157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="71" mass="8713" checksum="772335F8FD5EE189" modified="2016-09-07" version="1">MQILARYSDIGRSSKVEAQAHYHQEGITMWITWYMAKFARESRYQEIEVEYYDFNWKKQRQKLSGWTVQIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WNN3</accession>
    <name>A0A173WNN3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF0313 protein ERS852478_00010</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852478_00010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0313 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN40924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025576990.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN40924">
        <property type="protein sequence ID" value="CUN40924"/>
        <property type="gene ID" value="ERS852478_00010"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01251">
        <property type="entry name" value="UPF0313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022946">
        <property type="entry name" value="UPF0313"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024560">
        <property type="entry name" value="UPF0313_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013704">
        <property type="entry name" value="UPF0313_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32331">
        <property type="entry name" value="PTHR32331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11842">
        <property type="entry name" value="DUF3362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08497">
        <property type="entry name" value="Radical_SAM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01069">
        <property type="entry name" value="UPF0313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03904">
        <property type="entry name" value="SAM_YgiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="294"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="600"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="601"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="634"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN40924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="648" mass="73385" checksum="7462AAD34FA1CA35" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WR34</accession>
    <name>A0A173WR34_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable siderophore transport system ATP-binding protein YusV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yusV</name>
        <name evidence="5" type="ORF">ERS852478_00025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199473.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41406">
        <property type="protein sequence ID" value="CUN41406"/>
        <property type="gene ID" value="ERS852478_00025"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="25"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN41406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="385" mass="43259" checksum="47542FFC84B12A92" modified="2016-09-07" version="1">MSEKIADVIKETENNKADRQEQYFFRTDQLTVGYDGKPLIREINIQLKKGEILTLIGPNGAGKSTILKSITRQLATISGTVYLDKEKMAKMTNKEVSQKLAVVLTERMRPELMTCEDIVATGRYPYTGTLGILSAEDKTKVKKSMQTVHAWDLKDRDFTAISDGQRQRILLARAICQEPEIIVLDEPTSFLDIRHKLELLTILKQMVLDHQLTVIMSLHELDLAQKISDKVICVHGEYIEKYGAPEEIFTSEYIRKLYGITRGSYNAAFGCVEMDPPRGEPQVFVIGGNGSGIPYYRKLQRQGIPFAAGVLHTNDVDCQVASALADQVITEKPFESISQESYDKAVELMKKCQKVICPLKEFGTVNAANRELLRLARELGILAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WRI7</accession>
    <name>A0A173WRI7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylglyoxal synthase</fullName>
            <shortName evidence="1">MGS</shortName>
            <ecNumber evidence="1">4.2.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">mgsA</name>
        <name evidence="3" type="ORF">ERS852478_00003</name>
        <name evidence="4" type="ORF">ERS852523_00766</name>
        <name evidence="6" type="ORF">GT712_07885</name>
        <name evidence="5" type="ORF">GT728_12645</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
            <strain evidence="4 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">BIOML-A1</strain>
            <strain evidence="6 9">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone phosphate = methylglyoxal + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17937"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="EC" id="4.2.3.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylglyoxal synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.3" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN40698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP16829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000031">
        <property type="protein sequence ID" value="MZL34025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008702973.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1367"/>
    <dbReference type="EnsemblBacteria" id="CUN40698">
        <property type="protein sequence ID" value="CUN40698"/>
        <property type="gene ID" value="ERS852478_00003"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16829">
        <property type="protein sequence ID" value="CUP16829"/>
        <property type="gene ID" value="ERS852523_00766"/>
    </dbReference>
    <dbReference type="GeneID" id="66492928"/>
    <dbReference type="eggNOG" id="COG1803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008929">
        <property type="term" value="F:methylglyoxal synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019242">
        <property type="term" value="P:methylglyoxal biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00549">
        <property type="entry name" value="Methylglyoxal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004363">
        <property type="entry name" value="Methylgl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30492">
        <property type="entry name" value="PTHR30492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN40698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP16829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL34025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS88992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="131" mass="14800" checksum="81E3D38284D92EFF" modified="2016-09-07" version="1">MNLGIIAHNSKKVLIEDFCIAYKNILAKHEVYATGTTGRRIEEATSLHVHKFLAGSIGGDKQFMEMVERQDLDMVILFYNPVMIDPKEPDITSIVRRCDQYNIPVATNIATAELLILGLARGDLDWRLNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WUJ5</accession>
    <name>A0A173WUJ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate dehydrogenase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sdhA_1</name>
        <name evidence="4" type="ORF">ERS852478_00044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199477.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41975">
        <property type="protein sequence ID" value="CUN41975"/>
        <property type="gene ID" value="ERS852478_00044"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="94"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN41975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="537" mass="58356" checksum="8C53F827FFA04CE7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X1P6</accession>
    <name>A0A173X1P6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Formate acetyltransferase</fullName>
            <ecNumber evidence="5 14">2.3.1.54</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Pyruvate formate-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">pflB</name>
        <name evidence="18" type="synonym">pflB_1</name>
        <name evidence="20" type="ORF">BWLFYP14_02678</name>
        <name evidence="17" type="ORF">ERS852478_00181</name>
        <name evidence="18" type="ORF">ERS852523_00338</name>
        <name evidence="19" type="ORF">GT728_06085</name>
    </gene>
    <organism evidence="17 21">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 21 22" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 21">2789STDY5834863</strain>
            <strain evidence="18 22">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="19 24" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 24">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="20 23" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>acetyl-CoA + formate = CoA + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:11844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Fermentation; pyruvate fermentation; formate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.54" evidence="5 14"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000003">
        <property type="protein sequence ID" value="CUP04002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993932.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000032_gene377"/>
    <dbReference type="EnsemblBacteria" id="CUN45789">
        <property type="protein sequence ID" value="CUN45789"/>
        <property type="gene ID" value="ERS852478_00181"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04002">
        <property type="protein sequence ID" value="CUP04002"/>
        <property type="gene ID" value="ERS852523_00338"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00920">
        <property type="reaction ID" value="UER00891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008861">
        <property type="term" value="F:formate C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01678">
        <property type="entry name" value="PFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005949">
        <property type="entry name" value="Form_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019777">
        <property type="entry name" value="Form_AcTrfase_GR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01255">
        <property type="entry name" value="pyr_form_ly_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00850">
        <property type="entry name" value="GLY_RADICAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="10 13 14" id="KW-0556">Organic radical</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFL" evidence="16">
        <location>
            <begin position="1"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="15">
        <location>
            <begin position="626"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="13">
        <location>
            <position position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUN45789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CUP04002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MZL32786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VUX66306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="751" mass="84825" checksum="F1DE63A9B0DE1F11" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X6X4</accession>
    <name>A0A173X6X4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nicotinate dehydrogenase FAD-subunit</fullName>
            <ecNumber evidence="3">1.17.1.5</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Xanthine dehydrogenase FAD-binding subunit XdhB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ndhF</name>
        <name evidence="4" type="synonym">xdhB</name>
        <name evidence="3" type="ORF">ERS852478_00195</name>
        <name evidence="4" type="ORF">GT712_00485</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.17.1.5" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381430.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46188">
        <property type="protein sequence ID" value="CUN46188"/>
        <property type="gene ID" value="ERS852478_00195"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050138">
        <property type="term" value="F:nicotinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN46188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS87604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="294" mass="32154" checksum="29B780FAD8A7B1C5" modified="2016-09-07" version="1">MYDIENYYQAESVKDAVRLLNEHPDARIISGGSDVLIKIREGKFAGTSLVSIHGIKEIQGVKMADNGDIYIGAGTVFSHITNDAIIRKYIPVLGEAVDQVGGPQVRNIGTIGGNICNGAVSADSAPTVFSLNALLRLEDGKEGRLVPVKDFYLGPGRVDLRQGEILTYVIVPAKEYEGYHGHYIKYSMRNAMDIATISCSVVSKVDQQAGVIENVRITFGVAAPVPYRCTKAEEALKGMKIEESLYEKTAQLIREEINPRDSWRASRAFRLQIGGEIAARALRRTVELAGGDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X823</accession>
    <name>A0A173X823_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdopterin dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02735</name>
        <name evidence="3" type="ORF">ERS852478_00239</name>
        <name evidence="4" type="ORF">GT728_15010</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN47430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000041">
        <property type="protein sequence ID" value="MZL34473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703340.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN47430">
        <property type="protein sequence ID" value="CUN47430"/>
        <property type="gene ID" value="ERS852478_00239"/>
    </dbReference>
    <dbReference type="GeneID" id="66495783"/>
    <dbReference type="eggNOG" id="COG1319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN47430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="272" mass="30411" checksum="E5B606AB9622C3FE" modified="2016-09-07" version="1">MLKIKSYVKVNSLAEAYELNQKKTARILGGMVWMKMGNRAISTAIDLSGLGLDAISENDDEFVIGCMTPLHDLETNEALNTYTHGAMKESLCHIVGVQFRNCATVGGSIYGRYGFSDVLTMFLGMDTWVELYDAGRIPLTEFVNMKKDNDILVNIIVRKEPLLTCYLSQRNIKTDFPVLTCAASVIGNEARTVIGARPARAMIVEDKKQILKNFRNMTKKQKEEAIEAFAEYAAENVPTAGNMRGSKEYRTLLVKVLTRRAWEAVGGMKNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XMM7</accession>
    <name>A0A173XMM7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted hydrolase of the alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199582.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51915">
        <property type="protein sequence ID" value="CUN51915"/>
        <property type="gene ID" value="ERS852478_00350"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2819">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN51915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="208" mass="23685" checksum="7D253794C085D8B0" modified="2016-09-07" version="1">MTIYEYGNPDADTVLIQLTGDHELSVLKNEVEEIRKRTSTDFRLIAAKVDEWNYELSPWKAPAVFGNEDFGDGAVRTLEQILTLCTDKSRTYYIGGYSLAGLFSLWAAYQTDVFSGIAAASPSVWFPGFIEYMKEHEIKSETVYLSLGDREEKTRNSVMSQVGNCIRMGYGWLIEHGINCNLEWNQGNHFREPDIRIAKAFAWVMEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XRY5</accession>
    <name>A0A173XRY5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54702">
        <property type="protein sequence ID" value="CUN54702"/>
        <property type="gene ID" value="ERS852478_00443"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4709">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012963">
        <property type="entry name" value="DUF1700"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08006">
        <property type="entry name" value="DUF1700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN54702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="235" mass="25670" checksum="4109B2F2CBE7813E" modified="2016-09-07" version="1">MMDRAQFMQELEKLLADISETERQDALDFYNSYFDDAGAENEASVLRELGSPEKVAAIIKADLKGSAGGYEYGEYTEHGYEDARTKERGQMPERYEEESGTGKRFFRKGNQAVLILAVILLVFISPFVKGAVGGILTFAVGILLLPFWLIVGLGIGAVVLLVGGIAAVVAGAGLLAVMTGTGILTIGIGCLMIALAILMILGLISIAVRIVPKWFRKITDFFNRVLYRKRKEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XS47</accession>
    <name>A0A173XS47_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Putative multidrug export ATP-binding/permease protein SAV1866</fullName>
            <ecNumber evidence="11">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BWLFYP14_02046</name>
        <name evidence="11" type="ORF">ERS852478_00432</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026648721.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54363">
        <property type="protein sequence ID" value="CUN54363"/>
        <property type="gene ID" value="ERS852478_00432"/>
    </dbReference>
    <dbReference type="GeneID" id="66496063"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="44"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="370"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="403"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN54363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX65455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="612" mass="68817" checksum="0377AF6FFBE3E587" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XSX9</accession>
    <name>A0A173XSX9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIR2_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00401</name>
        <name evidence="3" type="ORF">ERS852523_01591</name>
        <name evidence="4" type="ORF">GT728_06320</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000013">
        <property type="protein sequence ID" value="CUP42769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000011">
        <property type="protein sequence ID" value="MZL32827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026648729.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000014_gene1232"/>
    <dbReference type="EnsemblBacteria" id="CUN53458">
        <property type="protein sequence ID" value="CUN53458"/>
        <property type="gene ID" value="ERS852478_00401"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP42769">
        <property type="protein sequence ID" value="CUP42769"/>
        <property type="gene ID" value="ERS852523_01591"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039444">
        <property type="entry name" value="SIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011202">
        <property type="entry name" value="UCP014677"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13289">
        <property type="entry name" value="SIR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014677">
        <property type="entry name" value="UCP014677"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIR2_2" evidence="1">
        <location>
            <begin position="143"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP42769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="522" mass="59818" checksum="5C8558F43114357F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XUB2</accession>
    <name>A0A173XUB2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">nadE</name>
        <name evidence="9" type="ORF">ERS852478_00437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199622.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54506">
        <property type="protein sequence ID" value="CUN54506"/>
        <property type="gene ID" value="ERS852478_00437"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
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            <position position="197"/>
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        </ligand>
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    <sequence length="638" mass="71764" checksum="318E96C97F672749" modified="2016-09-07" version="1"> </sequence>
</entry>
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            <strain evidence="10 14">2789STDY5834863</strain>
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    <reference evidence="12 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
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            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 17">BIOML-A12</strain>
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    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP12610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993618.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000016_gene3656"/>
    <dbReference type="EnsemblBacteria" id="CUN65359">
        <property type="protein sequence ID" value="CUN65359"/>
        <property type="gene ID" value="ERS852478_00711"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12610">
        <property type="protein sequence ID" value="CUP12610"/>
        <property type="gene ID" value="ERS852523_00633"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB" evidence="9">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN65359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP12610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS88106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX65020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="143" mass="16587" checksum="7D9DBCE092A446E8" modified="2016-09-07" version="1">MFMGEYNHTIDAKGRLIIPSKFRELLGEEFVLTRGLDGCLYIYPMDEWESFEMKLRSLPLTNKNARTFSRFFVAGATTCELDRQGRILVPQTLREFAGLEKDVVLTGNLNRIEVWSKEKWNEICDYDDMDSIAESMQDMGITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YVB4</accession>
    <name>A0A173YVB4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ion-translocating oxidoreductase complex subunit C</fullName>
            <ecNumber evidence="9">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Rnf electron transport complex subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnfC_1</name>
        <name evidence="9" type="synonym">rnfC</name>
        <name evidence="13" type="synonym">rnfC_3</name>
        <name evidence="12" type="synonym">rsxC</name>
        <name evidence="13" type="ORF">BWLFYP14_01740</name>
        <name evidence="11" type="ORF">ERS852478_00781</name>
        <name evidence="12" type="ORF">GT728_12615</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000030">
        <property type="protein sequence ID" value="MZL34021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67924">
        <property type="protein sequence ID" value="CUN67924"/>
        <property type="gene ID" value="ERS852478_00781"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00461">
        <property type="entry name" value="RsxC_RnfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010208">
        <property type="entry name" value="Ion_transpt_RnfC/RsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022026">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026902">
        <property type="entry name" value="RnfC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43034">
        <property type="entry name" value="PTHR43034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12225">
        <property type="entry name" value="DUF5981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13375">
        <property type="entry name" value="RnfC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01945">
        <property type="entry name" value="rnfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="594"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="623"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="629"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN67924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL34021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX64905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="654" mass="70986" checksum="8C997401ADBBD74D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z0P1</accession>
    <name>A0A173Z0P1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deoxyribonucleoside regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">deoR</name>
        <name evidence="4" type="ORF">BWLFYP14_00625</name>
        <name evidence="3" type="ORF">ERS852478_00838</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SorC transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000006">
        <property type="protein sequence ID" value="VUX62847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69834">
        <property type="protein sequence ID" value="CUN69834"/>
        <property type="gene ID" value="ERS852478_00838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007324">
        <property type="entry name" value="Sugar-bd_dom_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04198">
        <property type="entry name" value="Sugar-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sugar-bind" evidence="2">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN69834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX62847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="86" mass="9478" checksum="B73198E0335C234B" modified="2016-09-07" version="1">MLKQENVSGDIALRFFDHDGQECNTTLKERMISISMEQFKKIDRKISLVSGVSKANAVLSALKGGLVDVLILDSNLAEALLKLTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZAN2</accession>
    <name>A0A173ZAN2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA family ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Divergent AAA domain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Divergent AAA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BWLFYP14_01282</name>
        <name evidence="4" type="ORF">ERS852478_00909</name>
        <name evidence="6" type="ORF">GT712_08185</name>
        <name evidence="5" type="ORF">GT728_01230</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">BIOML-A1</strain>
            <strain evidence="6 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS89048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706995.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72853">
        <property type="protein sequence ID" value="CUN72853"/>
        <property type="gene ID" value="ERS852478_00909"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025831">
        <property type="entry name" value="RecG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038475">
        <property type="entry name" value="RecG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13749">
        <property type="entry name" value="HATPase_c_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlbA_2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_4" evidence="3">
        <location>
            <begin position="326"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN72853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL31854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS89048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX64197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="503" mass="57988" checksum="CD8A236C66DDCDE3" modified="2016-09-07" version="1">MVHFFDITKFNLYKEDNRREVKKANGGLPSSLWETYSAFANCYGGVIILGVAENKDGTWRTTGLKSTDRDKLLKHFWDTINNRKKVNVNLLSDQDVEIYEKDEDTIIVIYVPMANREQKPVYINDDIFGGTFRRNHEGDYHCTKLQVKAMLRDQTDNTMDMDVLDDVPISDLNYETIQGYRNRHRALKPAHPFGRLNDSEYLRSIGAAAISNIDKCLHPTAAGMLMFGDEYNIVRHFPEYFLDYREILDPTIRWTDRLQSSSGEWSGNICDFYFRVYNKLVKDIKVPFKTIDGNRIDDTPVHEALREALANCLINADFYGVRGIVVRKEADRIVFENPGYSRTGKQQMKKGGISDPRNKVLMKMFNLINIGERAGSGVPNIFNTWEDQGWVEPVIEEQFDPDRTLLILSFDKKQAIKTSDKKQAIKTSDKKQANKSCHKKQNQKTLENIEKIREYLSKNNISKTSDIAEYIGLSLPRTRAILKEIPDVSPIGNNSNRKWTLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZBP5</accession>
    <name>A0A173ZBP5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Primosomal protein DnaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dnaI_1</name>
        <name evidence="3" type="ORF">ERS852478_00901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002596493.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72605">
        <property type="protein sequence ID" value="CUN72605"/>
        <property type="gene ID" value="ERS852478_00901"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="125"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN72605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="284" mass="32347" checksum="9250BBBF7DF5EB24" modified="2016-09-07" version="1">MTDTIHNTILPMTDTTAEPEDYTGEDGLLYCGKCRKPKEAYFPEGKTFFGRDRHPSECDCQRAARKEREAAEKQRSHLETVERLKRQGFTDKTMQDWTFDNDNGSCPQMKSAAGYVERWEQIKDGNYGLLLWGRVGTGKSYFAGCIANALMEQEVPVCMTNFATILNDLAASFAGRNEYISRLCSFPLLIIDDFGMERGTEYGLEQVYNVIDSRYRSRKPLIVTTNLTLEELQHPEDTAHARIYDRLLEMCSPLCFTGENLRKAAAQGKMEQLKRLLAGKEICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZGK0</accession>
    <name>A0A173ZGK0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylneuraminate lyase</fullName>
            <ecNumber evidence="2">4.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nanA</name>
        <name evidence="2" type="ORF">ERS852478_00973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199861.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74760">
        <property type="protein sequence ID" value="CUN74760"/>
        <property type="gene ID" value="ERS852478_00973"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008747">
        <property type="term" value="F:N-acetylneuraminate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN74760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="305" mass="33345" checksum="9E4584099927CF7B" modified="2016-09-07" version="1">MKDITKYQGIIPAFYACYDDNGEISPERVEALTRHLIAKGVKGVYVGGSSGECIYQSVADRKLVLEHVMKAAEGKLTVIAHVACNNTTDSKELAAHAESLGVDAIAAIPPIYFHLPEYAIAEYWNDISSAAPNTDFVIYNIPQLAGVALTMPLFREMRKNPRVAAVKNSSMPVQDIQMFKMEGGEGFVVFNGPDEQLVSGLAMGADGGIGGTYAVMPELYLKIKELTDAGKVKEASEIQYVADAIIYAMCECHGNLYAVMKEILRIRENLNIGGVRKPLPEIIPEDMEQIKKCAGMIDEAIKKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZPL2</accession>
    <name>A0A173ZPL2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FtsX-like permease family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC-4 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199908.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78362">
        <property type="protein sequence ID" value="CUN78362"/>
        <property type="gene ID" value="ERS852478_01050"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027022">
        <property type="entry name" value="ABC_permease_BceB-typ"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018968">
        <property type="entry name" value="ABC_permease_BceB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR018968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN78362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="673" mass="75815" checksum="76FACC7A9F111AC4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZR64</accession>
    <name>A0A173ZR64_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAP2 superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_01065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78912">
        <property type="protein sequence ID" value="CUN78912"/>
        <property type="gene ID" value="ERS852478_01065"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="64"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN78912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="237" mass="27647" checksum="30E65C019B70C85D" modified="2016-09-07" version="1">MTKTEKIAAFREKYLPVWVILPLISIFVLNCLIYWGSGVLTADRYHFDFTMSLDRAVPLIPQFIWIYILAFPFWAVNYILAAQRGKDGFYRFVATDLTVHITCFIIFLVLPTTNVRPELAGTTWSQQMLKFVYLMDGGNSPSNLFPSIHCYVSWLSWRGVSKSENIPKWYQHFSLIFAILIIISTQVLKQHYLVDAIAGVALVELAWRFYSKGNRHEIFRHFFEKISEACSRWVNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZUW5</accession>
    <name>A0A173ZUW5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aminotransferase class V-fold PLP-dependent enzyme</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Cysteine desulfurase</fullName>
            <ecNumber evidence="5">2.8.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">iscS</name>
        <name evidence="8" type="ORF">BWLFYP14_00348</name>
        <name evidence="5" type="ORF">ERS852478_01068</name>
        <name evidence="7" type="ORF">GT712_13605</name>
        <name evidence="6" type="ORF">GT728_14275</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">BIOML-A1</strain>
            <strain evidence="7 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000037">
        <property type="protein sequence ID" value="MZL34333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000028">
        <property type="protein sequence ID" value="MZS90079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052523.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79015">
        <property type="protein sequence ID" value="CUN79015"/>
        <property type="gene ID" value="ERS852478_01068"/>
    </dbReference>
    <dbReference type="GeneID" id="66496221"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="4"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN79015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL34333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS90079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX67503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="384" mass="42110" checksum="54FFDE28F2286B6C" modified="2016-09-07" version="1">MEAYFDNSATTRCFEEVKDIVVKTMMEDFGNPSAMHQKGVDAEGYVKESARTLAQILKVTEKEILFTSGGTESNNLALIGGALANKRSGNHIITTAVEHAAVSQPVAFLQEQGFEVTILPVDGHGVVKLDALEKALRPDTILVSTMMVNNETGAVMPVEKIGAMIQEKCPKALYHVDAIQAFGKYRIYPKKWNIHLLSVSSHKIHGPKGVGFLYINSKAKVQPLILGGGQQNGMRSGTDNVPGIAGLGVAAKMMYQNFDEKVEHLYQLKERMAEGLSKIDDVVINGMPVREGAPHILSVSFLGIRSEVLLHTLEDRNIYVSAGSACSSHKRKPSATLSAMGMSNAQIENTVRISFSEENTFEEVDYCLEVLNEVLPMLKRYARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZX33</accession>
    <name>A0A173ZX33_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable manganese catalase</fullName>
            <ecNumber evidence="2">1.11.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydbD</name>
        <name evidence="2" type="ORF">ERS852478_01119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the manganese catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80841">
        <property type="protein sequence ID" value="CUN80841"/>
        <property type="gene ID" value="ERS852478_01119"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007760">
        <property type="entry name" value="Mn_catalase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05067">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN80841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="190" mass="21340" checksum="504DF010D5581003" modified="2016-09-07" version="1">MRGYYRVLHSGGPDGEISASLRYLSQRFTMPNRTTSALLNDIGTEELSHLEMVSTIVHQLTRDLSMEEIEKSGFGPYYIDHAVGVWPQAAGGIPFNACEFQSKGDPITDLFEDLAAEQKARSTYDNILRVVRNIPEIADPIKFLRAREVVHFQRFGEALQSIQEELDAKNFYAFTPGFDNPCTASCNSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZY83</accession>
    <name>A0A173ZY83_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81007">
        <property type="protein sequence ID" value="CUN81007"/>
        <property type="gene ID" value="ERS852478_01124"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN81007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="107" mass="12241" checksum="BECD9D3FFE0B4010" modified="2016-09-07" version="1">MLAEEIGHYRTSSGNILDQNKVESRKQEYRARLYGYNLKIGLTGLISAYEAGCGNLYEMAEYLNATEEYLKEAIQCYHSKYGVYAVVDNYVIYFEPFAVIHMISSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A141</accession>
    <name>A0A174A141_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsW_2</name>
        <name evidence="7" type="ORF">ERS852478_01139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199936.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81540">
        <property type="protein sequence ID" value="CUN81540"/>
        <property type="gene ID" value="ERS852478_01139"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN81540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="398" mass="43495" checksum="A7E143D80E0114FA" modified="2016-09-07" version="1">MENTKSQKKSYSTASSKSRARRKTKTDYYDYSLVAVIVLLTCFGLIMLYSTSSYMAQINYGSDMYFFKKQAIISVACIIMALIISRINYRILNRFSTALYVAALVLMALVKTPLGQSSHGAQRWLNLGPVQFQPAELAKIAVIVCLPYMIVHMGKKVHTLKGCMVLAVVGGGLALAAYVFTDNLSTAIIIFCITAGLIFVAHPDIKIFIIIAGVVIALAVIGVIFLNATVSVDGSGSFRLRRIMVWLHPEEYADSWGYQTIQALYAIGSGGFFGRGLGNSIQKLGSVPEAQNDMIFSIICEELGIFGGLIVLMLYAYLLYRLFVIAQNAPDMFGSLMVSGIFIHIALQVILNIAVVVNLMPNTGVTLPFISYGGTSIVFLMAEMGLALSVARQIKFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AC31</accession>
    <name>A0A174AC31_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN85967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006857255.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN85967">
        <property type="protein sequence ID" value="CUN85967"/>
        <property type="gene ID" value="ERS852478_01233"/>
    </dbReference>
    <dbReference type="GeneID" id="61431737"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041511">
        <property type="entry name" value="DBD_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18430">
        <property type="entry name" value="DBD_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN85967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="119" mass="13603" checksum="7693680294CEE7B0" modified="2016-09-07" version="1">MDARNNDFDFDFTPIGQAIKKARTAKGMTRDELSRIVDYDPRHLQAIENEGQKPSLELFIQLVTMFGVSVDEYIFPDNEVKKSSVRRRLDAELDKLNDKELLVIEATVSGLCKAKEPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AFD4</accession>
    <name>A0A174AFD4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703427.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000069.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86238">
        <property type="protein sequence ID" value="CUN86238"/>
        <property type="gene ID" value="ERS852478_01239"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7IJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN86238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="278" mass="30255" checksum="8A63363AE5BD8BA1" modified="2016-09-07" version="1">MSDNWVVQNLENALNTWNEKLAEIWQLITQSPENFKGGTIWNVIVDIHGAVQAIGLALLVLFFVVGVMRTCGNFAEVKRPEQALKLFIRFAIAKGAVTYGLELMMALFKIVQGMISTIMNAAGFGSAQQTVLPQEIVTAVEDCGFFESIPLWAVTLIGGLFITVLSFIMIMSVYGRFFKLYIYTAIAPVPLSAFAGEPSQSVGKSFIKSYAAVCLEGAVIVLACIIFSLFASSPPVVNPDAAAVTMVWSYIGELVFNMLVLVGAVKMADRVVREMMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AGE0</accession>
    <name>A0A174AGE0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3991 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199988.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86568">
        <property type="protein sequence ID" value="CUN86568"/>
        <property type="gene ID" value="ERS852478_01249"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025054">
        <property type="entry name" value="DUF3991"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13154">
        <property type="entry name" value="DUF3991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3991" evidence="1">
        <location>
            <begin position="127"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN86568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="328" mass="37509" checksum="2BE1123571AEF18D" modified="2016-09-07" version="1">MRTNRRYVQIDPDVLERVRQIDLLSYLREFEPSNLVKVKGTSNVYCTAEHDSLKISNGKWYWWSRGFGGYSALDYLIKVKEYDFVEAVEILTGQTMADWKPPAPKKNEPKVLLLPLKNKDCNRVIQYLFGRGIDYQLIQECIADGTLYESANYHNVVFIGKDESGTPKYAALRSTLGSTFKQDASGSDKRYSFRLLAREPTDTVHLFEAAIDLLSYATYLKCEGKDYKSESLLSLSGVYQPKKEMKDSKIPIALTTFLSANPQIKTIVLHLDNDKVGRLCTATLKELLQKDYKIVDDPPPVGKDFNDFLLSYLEIARPMPKRERSDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AH36</accession>
    <name>A0A174AH36_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3801 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF3801)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01256</name>
        <name evidence="3" type="ORF">GT728_16825</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000053">
        <property type="protein sequence ID" value="MZL34809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007037035.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86835">
        <property type="protein sequence ID" value="CUN86835"/>
        <property type="gene ID" value="ERS852478_01256"/>
    </dbReference>
    <dbReference type="GeneID" id="61860932"/>
    <dbReference type="eggNOG" id="ENOG502Z93C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024234">
        <property type="entry name" value="DUF3801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12687">
        <property type="entry name" value="DUF3801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN86835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="158" mass="17601" checksum="3A380EE5F2D56C28" modified="2016-09-07" version="1">MQDEVNEKTIALYIKTGKLTAQTLQKAMKAILSKGKKQLAKPPQGKQSLKQLMKQNAGVSNIEITEGNIKAFESTAKKYGIDFALKKDATESPPRYLVFFKGRDADVLTAAFKEFSAKKLTQEKKPSIRKLLSTLKEAAQGRNAERAKVKNKDREVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AKI5</accession>
    <name>A0A174AKI5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5-bromo-4-chloroindolyl phosphate hydrolysis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200012.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89092">
        <property type="protein sequence ID" value="CUN89092"/>
        <property type="gene ID" value="ERS852478_01322"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4915">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018770">
        <property type="entry name" value="ChloroindolylP_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10112">
        <property type="entry name" value="Halogen_Hydrol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN89092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="432" mass="48740" checksum="5E9FA0EF0C7F762C" modified="2016-09-07" version="1">MSENFDELGELGDKIKKIIDTAVSTKDYRQMTEDIKQTVGQTVNSAVNSAVDSGSEAIKNGLNNVFGTGNSQSGDSGVYRNKTKEFEEKRRREREQEQERQRIEKEKAKEKMLTLYERNTGGRMKGMMIAVSGGILASGMGLGTLVLSIFGAVGHMSSLVTGGTCFMAVGALTGVGLLAGGIKKLGKLERFQKYIDTLGNHTYCNFEQLSAAVNKPVKFVKKDIKKMIDDRWFRQGHIDEQETCLITSNETYLQYTQTQKALEQKKQEEEKHQAEQERNRKNTPPEVQEVLDKGNEFLDKIHRSNDAIPGMEISAKISRMELIVEKIFERAQKHPEIIPDLKKLMNYYLPMTVKLLDAYEEMDQQPVQGENIQASKKEIEDTLDTLNQAFEKLLDSVFQDTAWDVSSDISVLHTLLAQEGLTDDDFAKMKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AVT2</accession>
    <name>A0A174AVT2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage replisome organizer, putative, N-terminal region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN92921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200059.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN92921">
        <property type="protein sequence ID" value="CUN92921"/>
        <property type="gene ID" value="ERS852478_01401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010056">
        <property type="entry name" value="Phage_rep_org__N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09681">
        <property type="entry name" value="Phage_rep_org_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01714">
        <property type="entry name" value="phage_rep_org_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_rep_org_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN92921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="308" mass="36060" checksum="B961448928187611" modified="2016-09-07" version="1">MGKRYYWLKLPDDFFRQKPIKKLRRIAGGDTYTIIYLKMLLVSLKNEGKLFFDGVEENFTEEIALELDEEEENVKVTVQFLMAQGLLQLIDESEYELTECSRMVGSESASAERMRRLRDKKTSQCDIGVTQQLHLSDVEKEIEIEKDKEIENKYICPEVNSGQPQPKVEIEPVTESRTKVEIEPSCSKAELKVETEPAQADVFIKLPLINGDDYLVTKEYVKELKELYPAVDVEQALRNMRGWLDSNPRNKKTPRGIKRFITGWISREQDKAPRVPDKPKPVSQNRFNNFHQRDYDFAEYERQLLKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B080</accession>
    <name>A0A174B080_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200062.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93038">
        <property type="protein sequence ID" value="CUN93038"/>
        <property type="gene ID" value="ERS852478_01405"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN93038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="64" mass="7523" checksum="85707F907496F1EC" modified="2016-09-07" version="1">MAKQIIRSIRKGSVQWNEEDRLQMVSMLAKAGYAVQIVRKEIPSSETRKTTQYEYVIEYGERVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B2B4</accession>
    <name>A0A174B2B4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted phosphoadenosine phosphosulfate sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704622.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93785">
        <property type="protein sequence ID" value="CUN93785"/>
        <property type="gene ID" value="ERS852478_01429"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="1">
        <location>
            <begin position="30"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN93785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="379" mass="44766" checksum="4DA5CBEE1AD92E09" modified="2016-09-07" version="1">MAVKRCESNIDVVKAAEIRIKNVFGNGLPVFFSFSGGKDSLCLAQLMVNLANRGEINMKQLTVQFIDEEAIFPCMEEMTKKWRRIFMMMGAKFEWYCVEVKHYNCFNELSNDETFICWDSTKQDVWVRQPPSFAIRSHKLLRPRIDAYQDFLPRTTVSGITMVGIRTAESVQRLQNIASMTKAGNRMTSKKQVFPIYDWTDNDVWLFLLRNYVDIPEIYLFLWQSGSSKRQMRVSQFFSVDTARSLVKMNEYYPDLMERVIRREPNAYLAALYWDSEMFGRSSRKRKESEQGQEQKDYKQELINLFDHMEIFDTPHKRHVAERYRNFFIAVSAIATPEDCKHIYEGLISGDPKMRTFRALYQRIYGRYINNAKKERKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B2U0</accession>
    <name>A0A174B2U0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94519">
        <property type="protein sequence ID" value="CUN94519"/>
        <property type="gene ID" value="ERS852478_01452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN94519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="306" mass="33855" checksum="68F5C83B0E05E66A" modified="2016-09-07" version="1">MQESEDCVYYSSGARTKQVIQDYFKKWGIPIGKYAGPDVTHGVIKEDKKKLGTMVKDILDEAKKKGGGYSVIRSVKGKAQILAIGSNKNIYHFAETENLISVSHKISTSGMVTRVKILGEADDDKRRPVEATVDGQTKYGIRQKILTRGKDDSLDEAKKEAKEVLEDDGKPKQEIKVVAVDLPIIRKGDIIHLKMSTGSGYYWVTAITHDCDKMEMTMTLKKTKLKSSPSKKDNKKKDGDYSIGDTVNFHGGYHYVSSDATSGYKVSAGKATITHSNPGSAHPWCLENVNWAETHVCGWVDEGSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BM66</accession>
    <name>A0A174BM66_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LexA repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_024720754.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01653">
        <property type="protein sequence ID" value="CUO01653"/>
        <property type="gene ID" value="ERS852478_01628"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO01653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="243" mass="27421" checksum="B11881F4EBE3E0AE" modified="2016-09-07" version="1">MRDFGEILAENRKKKGYSQSDLVDLLSQEGIQVTTKAISKWETNAREPALHVFLTLCQLLDIEDIYESFFGENPYNIMSGLNEEGRNKLIEFADILKASKKFSPLSAKIIPFHHPVEITWEPVSAGTGNYLEDSVKETYDVGHLAPEQTDFGVRISGDSMEPLYHTDDVAWIQKKDSLANGEIGIFYLNGNTYIKELHDEPDGVYLISLNQKYRPIQVLESDSFKIFGKVIGKCKGAEIPGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BND9</accession>
    <name>A0A174BND9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">araC_1</name>
        <name evidence="3" type="ORF">ERS852478_01615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01205">
        <property type="protein sequence ID" value="CUO01205"/>
        <property type="gene ID" value="ERS852478_01615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="220"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO01205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="324" mass="37169" checksum="DF3E307E26830B55" modified="2016-09-07" version="1">MRDMIDSILENSHSISGVALKNTPNSRELLLDQATGKGRMTFYTLFPGLTVAFIFVNAPAWPESDENSDLRPLLINYCISGRSELLLDDGSYIYLKENDFCVSEQTAQKEYIFPTGKYQGIKIYFDLALLSQSSGQIMETFDIDPAQLEELYCRKRKTYINEADHDLTAVFQKLWSLSENPSPFYLRIYTLELLHELLCMEIHPSKTCGFYTETQVEIAKRAAQIISEDLHKHIPISQIAERFSVSETSLKNYFRGVYGQNISTWLREIRMDTAAELLSNTKRPIAEISEQVGYSNQGKFAAVFKKRFGLSPLEYRRLKNLDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C5Y8</accession>
    <name>A0A174C5Y8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hyaluronan synthase</fullName>
            <ecNumber evidence="2">2.4.1.212</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hyaD_2</name>
        <name evidence="2" type="ORF">ERS852478_01779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.212" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200260.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPC010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07285">
        <property type="protein sequence ID" value="CUO07285"/>
        <property type="gene ID" value="ERS852478_01779"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO07285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="254" mass="29173" checksum="8C624545BFA53C7D" modified="2016-09-07" version="1">MNKPLVSVIMPVYNGEKYIRKAVESVYEQEVSLELLVIDDGSTDHTEEVLSAYEGREDFRYIKNQQNMGAAGSRNRGVGLAQGTYIAFLDADDWWEPGKLKEQLKRLEETGYVLCSTGRELMKADGSSTGRTIPVKEKITYRELLKHNSINCSSVILRRDVAREFPMEHDDSHEDYITWLKILRKYGCAAGINKPYLKYRLSEGGKSRNKLKSAAMTYNVYRYAGYGRIRSCIFFCSYAVHGIWKYCYCSLRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C9S8</accession>
    <name>A0A174C9S8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonucleases G and E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_01848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10242">
        <property type="protein sequence ID" value="CUO10242"/>
        <property type="gene ID" value="ERS852478_01848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
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    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
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    </dbReference>
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        <property type="entry name" value="SSF49373"/>
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    </dbReference>
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        <property type="entry name" value="SSF55797"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
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    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019032" evidence="3">
        <location>
            <begin position="25"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="786"/>
            <end position="880"/>
        </location>
    </feature>
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        <location>
            <begin position="343"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
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            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="764"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO10242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="880" mass="96460" checksum="6FD1893CC38037DB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CCK7</accession>
    <name>A0A174CCK7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peroxiredoxin bcp</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Putative peroxiredoxin bcp</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Thioredoxin-dependent thiol peroxidase</fullName>
            <ecNumber evidence="5 6 8">1.11.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bcp_1</name>
        <name evidence="8" type="synonym">bcp_2</name>
        <name evidence="8" type="ORF">BWLFYP14_02485</name>
        <name evidence="5" type="ORF">ERS852478_01881</name>
        <name evidence="7" type="ORF">GT712_15430</name>
        <name evidence="6" type="ORF">GT728_15570</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">BIOML-A1</strain>
            <strain evidence="7 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.15" evidence="5 6 8"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000045">
        <property type="protein sequence ID" value="MZL34575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000037">
        <property type="protein sequence ID" value="MZS90422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057979.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11261">
        <property type="protein sequence ID" value="CUO11261"/>
        <property type="gene ID" value="ERS852478_01881"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO11261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL34575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS90422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="151" mass="17029" checksum="CAF394A7B7D55F8C" modified="2016-09-07" version="1">MLEVGVKAPDFELPDQNGKIHRLSDYAGKKVVLYFYPKDNTAGCTKQACGFSERYPQFIEKGAVILGVSKDSVSSHKRFEEKYGLAFTLLADPERKVIEAYDVWKEKKNYGKVSMGVVRTTYLIDEQGVIIKANDKVKAADDPENMLKELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CL10</accession>
    <name>A0A174CL10_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fucose 4-O-acetylase and related acetyltransferases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577095.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12276">
        <property type="protein sequence ID" value="CUO12276"/>
        <property type="gene ID" value="ERS852478_01915"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="12"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO12276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="364" mass="41803" checksum="936705B60E9536EF" modified="2016-09-07" version="1">MTNGLKKEDSAALKGLAVLLLIFHHCYRLADRIERYQVDLCGLTTEQLVAIAECCKICVAIFAFVSGYGLMYGYSAKMKNKEKYAVSEWISGHLLSTMSGFWFTAAVSYLIYFGLGLKDPSKWGETFYERGFAVFADILGISRLLETESLNGAWWYMSAAFVFIILLPLLDGTIEKFGGIFCIAVIFLLPRILGIGFQGGSKPYSFLLIFVAGMLCCKYNFFQKLHEYRRKKLKFICLSALLCAGLFLYHKIDLKIFWEFRYALVPFLLILFCVEYLFRITPVSLFLQYLGKHSMNIWLVHTFVRDSLGKYVFALKKFWLIPVAVLVISLGISYCLDFLKKITGYQKLIRLLKKKVTEHYAVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CQ28</accession>
    <name>A0A174CQ28_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rmlA1_1</name>
        <name evidence="7" type="ORF">ERS852478_01990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707531.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15432">
        <property type="protein sequence ID" value="CUO15432"/>
        <property type="gene ID" value="ERS852478_01990"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO15432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="298" mass="33459" checksum="3B9C0D391832BBC2" modified="2016-09-07" version="1">MKGIILAGGSGTRLYPLTMVTSKQLLPIYDKPMIYYPMSVLMNAGIRDILIISTPQDTPRFEELLGDGHQFGVHLTYAVQPSPDGLAQAFIIGEEFIGNDTVAMVLGDNIFAGHGLKKRLKAAVKNAESGEGATVFGYYVDDPERFGIVEFDHEGKAISIEEKPEHPKSNYCVTGLYFYDNRVVEYAKNLKPSARGELEITDLNRIYLEKGELNVELLGQGFTWLDTGTHESLVEATNFVKTMESHQHRKIGCLEEIAYLNGWITKEDVLKVYEILKKNQYGQYLKDVLDGKYLDVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CR25</accession>
    <name>A0A174CR25_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-oxoprolinase subunit A</fullName>
            <shortName evidence="1">5-OPase subunit A</shortName>
            <ecNumber evidence="1">3.5.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-oxoprolinase (ATP-hydrolyzing) subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pxpA</name>
        <name evidence="2" type="ORF">ERS852478_01996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-oxo-L-proline + ATP + 2 H2O = ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10348"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.5.2.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex composed of PxpA, PxpB and PxpC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LamB/PxpA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707546.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15623">
        <property type="protein sequence ID" value="CUO15623"/>
        <property type="gene ID" value="ERS852478_01996"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00691">
        <property type="entry name" value="PxpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="PTHR30292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO15623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="256" mass="27636" checksum="2E7BB5D6D47F129E" modified="2016-09-07" version="1">MYTVDLNSDLGESFGNYKIGNDDKVIPLISSANVACGYHASDPVVMGNTLAMAREAGIRIGAHPGFPDLMGFGRRNLSVSPAEAKAYVLYQLGALDAFCRVTGVKMQHVKPHGALYNMAAEDYALSTAICEAIKEFDSSLIVLALSGGQLAKAAQDMGLRTAMEVFADRAYEEDGTLVNRRKEGAVITDENEAIVRVIRMVKEKKITAITGKDIDIQADSVCVHGDGAKALAFVEKIREAFAKEGIQIRSLDEFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CR97</accession>
    <name>A0A174CR97_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conjugal transfer protein TrbP</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TraX protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_00389</name>
        <name evidence="2" type="ORF">ERS852478_01969</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO14729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707499.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO14729">
        <property type="protein sequence ID" value="CUO14729"/>
        <property type="gene ID" value="ERS852478_01969"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031QMC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008875">
        <property type="entry name" value="TraX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05857">
        <property type="entry name" value="TraX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO14729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX62260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="246" mass="29138" checksum="DB3DD3E54CE571D6" modified="2016-09-07" version="1">MTTKLPASFLPAKFQVLSGSALKLIAITLMLIDHTGLMILYNYPATTATLFSFGGVDYSWYRIFRDIGRAAFPIFCFLLVEGFLHTHNRKKYGLNLFLFACISEIPWNFMFTNTWRYEKQNVFFTLFLGYLAFCALEYFWDNQKMQLVCVLALLTVSVFLKADYGWRGFVFLLIMYWFRNDKTAQAIIGSCWLYYEWKACFAFLSINMYNGERGFVKGRFLKYVFYWFYPVHITILVILRKLLFHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CT28</accession>
    <name>A0A174CT28_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Argininosuccinate lyase</fullName>
            <shortName evidence="7">ASAL</shortName>
            <ecNumber evidence="3 7">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">argH</name>
        <name evidence="12" type="synonym">argH1</name>
        <name evidence="12" type="ORF">BWLFYP14_00396</name>
        <name evidence="10" type="ORF">ERS852478_01976</name>
        <name evidence="11" type="ORF">GT728_09050</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO14968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707514.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO14968">
        <property type="protein sequence ID" value="CUO14968"/>
        <property type="gene ID" value="ERS852478_01976"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="8">
        <location>
            <begin position="7"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="9">
        <location>
            <begin position="364"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO14968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL33340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX62274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="459" mass="51614" checksum="6D1515BF4C805AF1" modified="2016-09-07" version="1">MAQLWGGRFTKETDKLVYNFNASISFDQKFYEQDIRGSKAHVAMLARQGILTAEEKDQIEAGLDGILADVRSGKLEITSEYEDIHSFVEANLIDRIGDAGKKLHTGRSRNDQVALDMKLYVRDEIDETDELVKKLLEALQKIMEENVHTYMPGFTHLQKAQPVTLAHHVGAYFEMFVRDRSRLADIRKRMNTCPLGAGALAGTTYPLDREYTAQLLGFDGPTRNSMDSVSDRDYVIELLSAFSTIMMHMSRFCEEIIMWNSNEYRFVEIDDAYSTGSSIMPQKKNPDIAELVRGKTGRVYGALTSILTTMKGIPLAYNKDMQEDKELTFDAIDTVKGCLALFTGMISTMQFNKQNMEASAKNGFTNATDAADYLVNHGVPFRDAHGIVGRLVLTCIDKGISLDELPLEEYKAISPVFENDIYEAISMKTCVEKRMTIGAPGPDVMEKVIAENKKYLEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CWF3</accession>
    <name>A0A174CWF3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1292 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02012</name>
        <name evidence="3" type="ORF">GT712_10245</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000018">
        <property type="protein sequence ID" value="MZS89438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707569.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16170">
        <property type="protein sequence ID" value="CUO16170"/>
        <property type="gene ID" value="ERS852478_02012"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YNK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO16170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS89438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="125" mass="13292" checksum="3E8FC5BC2C64CBCF" modified="2016-09-07" version="1">MSDEFTAGGCNPSDCASCGGGCSSAGGCDPVENHKTITLTMEDDTEVECAILTVFPVDAKEYIALLPLDENGQNESGEVYLYAFARTESGDPMLSNIESDEEYAKAAVAFDTVLQNAKDSMEKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D3C5</accession>
    <name>A0A174D3C5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Protease synthase and sporulation negative regulatory protein PAI 1</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">paiA_1</name>
        <name evidence="5" type="ORF">BWLFYP14_02362</name>
        <name evidence="2" type="ORF">ERS852478_02083</name>
        <name evidence="4" type="ORF">GT712_14220</name>
        <name evidence="3" type="ORF">GT728_13920</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO18366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000035">
        <property type="protein sequence ID" value="MZL34270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000030">
        <property type="protein sequence ID" value="MZS90193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707691.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18366">
        <property type="protein sequence ID" value="CUO18366"/>
        <property type="gene ID" value="ERS852478_02083"/>
    </dbReference>
    <dbReference type="GeneID" id="66493757"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO18366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="156" mass="18200" checksum="99B1404CD713C970" modified="2016-09-07" version="1">MEIQIRQATIQDLNVLMQWRMEVLHEVFSIPSERSVTELESENRRYYQTELPQGGHIACFAYVGEEIVGCGGICLYHEMPSPDNLNGKCAYLMNIYTRPQFRGHGIGNRIVRWLVEQARQRHISKIYLETSDKGRPLYQTIGFADMKDMMKLSREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D5H3</accession>
    <name>A0A174D5H3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacterial protein of uncharacterized function (DUF961)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200572.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20784">
        <property type="protein sequence ID" value="CUO20784"/>
        <property type="gene ID" value="ERS852478_02140"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010365">
        <property type="entry name" value="DUF961"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038620">
        <property type="entry name" value="YdcP-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06125">
        <property type="entry name" value="DUF961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO20784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="127" mass="14228" checksum="3316F6110F858F10" modified="2016-09-07" version="1">MRLANGIVIDKEKTFGVLKFSALRREVHVQNEDGSVSEEIKERTYDLKCNTQGRMIQVSVPATIPLKDYDYNAEVELINPVADTVANANYRGADVDWYVKTDDIVLKNKGTHAGNPQNNAPQQPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D652</accession>
    <name>A0A174D652_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Signal peptidase I</fullName>
            <ecNumber evidence="4 6">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sipT_1</name>
        <name evidence="10" type="synonym">lepB</name>
        <name evidence="9" type="synonym">sipT_2</name>
        <name evidence="12" type="ORF">BWLFYP14_02800</name>
        <name evidence="8" type="ORF">ERS852478_02098</name>
        <name evidence="9" type="ORF">ERS852523_01753</name>
        <name evidence="11" type="ORF">GT712_17115</name>
        <name evidence="10" type="ORF">GT728_16265</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 6"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000015">
        <property type="protein sequence ID" value="CUP47964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000049">
        <property type="protein sequence ID" value="MZL34704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000048">
        <property type="protein sequence ID" value="MZS90731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000088_gene4037"/>
    <dbReference type="EnsemblBacteria" id="CUO19478">
        <property type="protein sequence ID" value="CUO19478"/>
        <property type="gene ID" value="ERS852478_02098"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP47964">
        <property type="protein sequence ID" value="CUP47964"/>
        <property type="gene ID" value="ERS852523_01753"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="23"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO19478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP47964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL34704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS90731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX66426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="189" mass="21778" checksum="7EED37A91B0B2AA6" modified="2016-09-07" version="1">MENEEKNQTEQSDKSRSVWRELWDYAKIIIAVFVIAFLLGHFVYINARVPSGSMEETIMTGDRVFGNRLAYIKDDPERFDIVIFKYPDDPSQLFVKRVIGLPGETVNIVDGKVYINDSEEPLDDSFCPETPEGSFGPYTVPEGCYFMLGDNRNHSMDSRYWQNPFVEEDAIEAEVAVRYWPLNKIGTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D881</accession>
    <name>A0A174D881_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor sigM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sigM_3</name>
        <name evidence="4" type="ORF">ERS852478_02169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21653">
        <property type="protein sequence ID" value="CUO21653"/>
        <property type="gene ID" value="ERS852478_02169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="119"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO21653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="185" mass="22011" checksum="BB84B45D3B03C20E" modified="2016-09-07" version="1">MKGVSGAKIKEGGMIEVDNQILLKLYSLYQKELYLYLYSLCGDRHLAEDLLHETFLKALLALPDGHGNMRAWLYMVARNLFYNQQKKKSREILMDEQIYPLEEKTEKGLPEKIFEEEDRRMLYQAIRRLDIKKREIIQMQYFGGMTQKEIAAVLHITLENVRVLAYRARKELKKYLEECRKEESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DA15</accession>
    <name>A0A174DA15_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381168.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22481">
        <property type="protein sequence ID" value="CUO22481"/>
        <property type="gene ID" value="ERS852478_02194"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033RAZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009343">
        <property type="entry name" value="DUF1002"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06207">
        <property type="entry name" value="DUF1002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019867" evidence="1">
        <location>
            <begin position="27"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO22481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="150" mass="16465" checksum="A81777FC16B5EC51" modified="2016-09-07" version="1">MRIKKAGILIIAAAITCTTPAVPVMAADTSESVQEIISDNEIDSLVSDPDKVVDIIMYVKNEAAKQDISDDQIRSLIQTAESTAGVSLSEEEENRIIKIVKQIKDSDIDEEQLRSAVTKAYNKLEEMGIGKEEVKGILHKLADFAKSLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DAP2</accession>
    <name>A0A174DAP2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antirestriction protein (ArdA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200583.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21140">
        <property type="protein sequence ID" value="CUO21140"/>
        <property type="gene ID" value="ERS852478_02151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009899">
        <property type="entry name" value="ArdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041893">
        <property type="entry name" value="ArdA_dom3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07275">
        <property type="entry name" value="ArdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO21140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="163" mass="19100" checksum="9A0E15B733AC97B5" modified="2016-09-07" version="1">MEECSVLIETTKSAEDKTSRWFDLPIDYELFRDLLGVEADSKDYQITDMKLPFAGDIVRTTSVRRLNKLYFAYTDLSPEVQQAYKELIPYCGGVEDLLQKSEEFLFYPECHNIMDVARYRLEHNIEFSALSEKGKKYFNLEAYAHELEEKGRYALCNNGMFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DD04</accession>
    <name>A0A174DD04_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gliding-associated putative ABC transporter substrate-binding component GldG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200605.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21930">
        <property type="protein sequence ID" value="CUO21930"/>
        <property type="gene ID" value="ERS852478_02177"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019196">
        <property type="entry name" value="ABC_transp_unknown"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09822">
        <property type="entry name" value="ABC_transp_aux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="ABC_transp_aux" evidence="2">
        <location>
            <begin position="63"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO21930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="494" mass="55139" checksum="B5D7F5B9126B76BB" modified="2016-09-07" version="1">MKLKEKMKNNKHKKFDKKKLIGTISKKHIKNGSYTMVMSVIFIAVVVVLNMIVNAIPSKYSEIDISSQKLYSIGDDTKAMLKDLDKDVTIYQIAQSGSEDENITNLLKKYEDESKHIKVEQKDPVVNPKFVTEYTSDDLSANSLIVVCGDRNKVIDYNNIYESTMDYQTYSSQTTGFDGEGQITSAIGYVTSEDLPILYTLEGHGEKEMDSTIKEDIEKANMDIQSLNLLTEGSVPDDADCLFIDSPSTDISEDEKTAIIDYLENGGKAMIFSDYTTEDLPNFDAVLENYGVQREAGIVFEGDNQHYAMQMPYYLVPTINSTDASSETVSGGYYVLVPYAQGIKKMDDVRDTVTINSILTTSDQAYSKTDLNSDTLEKEDGDEAGPFDLGVSITETLDDDKETQIVYYSTSNLMESQVNQMVSGGNEKLIIESLKWMTDTEDSATVSIPSKSLSVSYLTLTDYDAAFWKICTIGLIPGFFLVVGFAVWMKRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DIN7</accession>
    <name>A0A174DIN7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">purM</name>
        <name evidence="15" type="ORF">ERS852478_02226</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200625.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24005">
        <property type="protein sequence ID" value="CUO24005"/>
        <property type="gene ID" value="ERS852478_02226"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="60"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="172"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO24005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="341" mass="36403" checksum="9F889273441190AA" modified="2016-09-07" version="1">MDYKTAGVDIEAGYKSVELMKEHVKRTMREEVLGGLGGFSGAFSLAKIKEMEEPVLLSGTDGCGTKVKLAMVMDKNDTIGIDAVAMCVNDIACAGGEPLFFLDYIACGKNYPEKIAAIVGGVAEGCVQSDAALIGGETAEHPGLMPEDEYDLAGFAVGVCDKKEMITGEELKAGDVLIGMASTGVHSNGFSLVRKVFDMTKESLDTYYEELGTTLGEALLAPTRIYVKALKSIKNAGVRVHACSHITGGGFYENIPRMLKEGTRAVVEKNSYPVLPIFKLLAEKGNIDEQMMYNTYNMGLGMILAVDAADVDKTMEAIKAAGDTPYVVGRIEDGEKGVTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DIY1</accession>
    <name>A0A174DIY1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="11">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">cysS</name>
        <name evidence="14" type="ORF">ERS852478_02279</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200669.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25552">
        <property type="protein sequence ID" value="CUO25552"/>
        <property type="gene ID" value="ERS852478_02279"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DALR_2" evidence="13">
        <location>
            <begin position="357"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="11">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="11">
        <location>
            <begin position="268"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO25552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="469" mass="53554" checksum="06F6AA5C4653D397" modified="2016-09-07" version="1">MKLFNTLTRRKEEFVPLEEGKVRMYVCGPTVYNLIHIGNARPMIIFDTVRRYMEYKGYEVNYVSNFTDVDDKIIKKAIEEGVSAQEISERYIAECKKDMDGMNVKPATTNPQATQEIDGMISMIQTLVDKEYAYPAADGTVYFRVKKFKEYGKLSHKNLDDLQSGFRSLQVSGEDQKEDPLDFVLWKPKKEGEPSWPSPWCDGRPGWHIECSVMAKKYLGDEIDIHAGGEDLIFPHHENEIAQSECCNDKIFAKYWMHNAFLNIDNRKMSKSLGNFRTVREISEQYDLQVLRFFMLNAHYRSPLNFSADLMEAAKNALERITDAAANLKDRKAAAQTDTATDAEKELLAQAQEFVKKFEEAMDDDFNTADALAAIFELVKFANTNVSEASSAEFAGTLLDTMVKLCDVLGLKAVKTEEILDKEIEDLIAERQEARKAKNFARADEIRDELLAKGIILKDTREGVKWKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DN01</accession>
    <name>A0A174DN01_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutaminyl-tRNA synthetase</fullName>
            <shortName evidence="8">GlnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">glnS</name>
        <name evidence="13" type="ORF">BWLFYP14_01502</name>
        <name evidence="12" type="ORF">ERS852478_02273</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705518.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25386">
        <property type="protein sequence ID" value="CUO25386"/>
        <property type="gene ID" value="ERS852478_02273"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
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    </dbReference>
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        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
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        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
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    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
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        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
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    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="27"/>
            <end position="336"/>
        </location>
    </feature>
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        <location>
            <begin position="340"/>
            <end position="529"/>
        </location>
    </feature>
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        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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            <begin position="40"/>
            <end position="46"/>
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        <ligand>
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            <position position="66"/>
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        <ligand>
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        </ligand>
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        <location>
            <position position="211"/>
        </location>
        <ligand>
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        </ligand>
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        <ligand>
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            <dbReference type="RuleBase" id="RU363037"/>
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            <dbReference type="Pfam" id="PF03950"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CUO25386.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VUX64649.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
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    <sequence length="555" mass="63714" checksum="9635296AE73D3A69" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DQF7</accession>
    <name>A0A174DQF7_9FIRM</name>
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        <submittedName>
            <fullName evidence="4">Rhamnulokinase</fullName>
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        </submittedName>
    </protein>
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                <consortium name="Pathogen Informatics"/>
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            <strain evidence="4 5">2789STDY5834863</strain>
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        <property type="project" value="UniProtKB-EC"/>
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            <dbReference type="Pfam" id="PF02782"/>
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        <source>
            <dbReference type="EMBL" id="CUO26120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DQQ2</accession>
    <name>A0A174DQQ2_9FIRM</name>
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        <submittedName>
            <fullName evidence="4">BMC domain-containing protein</fullName>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ccmK2_1</name>
        <name evidence="6" type="ORF">BWLFYP14_01557</name>
        <name evidence="3" type="ORF">ERS852478_02311</name>
        <name evidence="5" type="ORF">GT712_12805</name>
        <name evidence="4" type="ORF">GT728_12230</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">BIOML-A1</strain>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZL33946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26589">
        <property type="protein sequence ID" value="CUO26589"/>
        <property type="gene ID" value="ERS852478_02311"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG4577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011238">
        <property type="entry name" value="Organelle_shell_prot_PduT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034834">
        <property type="entry name" value="PduT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="86"/>
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            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO26589.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZL33946.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX64703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="182" mass="19261" checksum="1DA7D9A57EFB3608" modified="2016-09-07" version="1">MSKAIGMIEFKTTSTGVTAADAMVKTSEVEIVEAQTVCPGKYIAIITGDLSAVKAAVDTAVTTYEDKCIDSFVLGNPHESIFPAIYGTTQVEDISALGILETYDAASIIEAADQAAKTAIVDLIELRIAKGMCGKSYMMITGEVSAVEASIDRAKELVAAKGMYLDSSVIAHPDRRMIDSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
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    </protein>
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        <name evidence="3" type="ORF">ERS852478_02391</name>
        <name evidence="5" type="ORF">GT712_04530</name>
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        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
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    </reference>
    <reference evidence="4 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
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                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 9">BIOML-A12</strain>
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                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29733">
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        <property type="gene ID" value="ERS852478_02391"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DWD2</accession>
    <name>A0A174DWD2_9FIRM</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="119"/>
        </location>
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        <location>
            <begin position="40"/>
            <end position="75"/>
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    </feature>
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        <location>
            <begin position="78"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO28518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
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    </evidence>
    <sequence length="119" mass="13148" checksum="BAAACF52E0034939" modified="2016-09-07" version="1">MKKIKYFMITGMLLASIGLAGCGKKSEDDITNKEIYQDDLEPLTEEELNEMDADTSDEDMKQIDEPEEETADITDTTDATETTDKAETSDSSAKKTADKTETSDSADTTKSETKTKTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DZG0</accession>
    <name>A0A174DZG0_9FIRM</name>
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        <submittedName>
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        <submittedName>
            <fullName evidence="2">Staphylococcal virulence regulator protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_12</name>
        <name evidence="4" type="synonym">mepA_1</name>
        <name evidence="4" type="ORF">BWLFYP14_00103</name>
        <name evidence="2" type="ORF">ERS852478_02433</name>
        <name evidence="3" type="ORF">GT728_01835</name>
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        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
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                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
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                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
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                <person name="Bullock K."/>
                <person name="Deik A."/>
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                <person name="Pierce K.A."/>
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            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CUO31002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31002">
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        <property type="gene ID" value="ERS852478_02433"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MATE_fam"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO31002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL31974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="447" mass="48736" checksum="4FF747CE1FB15657" modified="2016-09-07" version="1">MKEQQHIFTNKMLRTLLIPVIFEQVLNSLMGTVDTMMVSNVGSAAISAVSLVDSINVLVIQAFSALAAGGAILCSQYIGQKNHEMANKSARQVLFIITAISVAVTALCLLFRVPLLKLIFGKVEADVMTASQVYFFYTALSFPFIALYDAGASIFRSQGNTRGPMTVSVISNVINIGGNAALIWGFNMGVAGAAIATLASRVFCAVVVLWQLRMDRQPIVVRNYRQIRPDGKMIRRVLALGIPSGIENSMFQLGKLAIQSSVSTLGTVAIAAQAMTNILENLNGIAAIGVGIGLMTVVGQCLGAGRKDEAVYYIKKLSVLAEIIVVASCLLVFALTIPVTKLGGMESESARMCFHMISWITVVKPIVWTLAFIPAYGLRAAGDVKFSMLTSCITMWTFRFCLCVYLIRFRGFGPMAVWIGMFTDWTVRGIVFSLRFHSRKWLKHKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DZT0</accession>
    <name>A0A174DZT0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0210 protein BWLFYP14_00146</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_00146</name>
        <name evidence="2" type="ORF">ERS852478_02390</name>
        <name evidence="4" type="ORF">GT712_04535</name>
        <name evidence="3" type="ORF">GT728_02095</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0210 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL32025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704727.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29706">
        <property type="protein sequence ID" value="CUO29706"/>
        <property type="gene ID" value="ERS852478_02390"/>
    </dbReference>
    <dbReference type="GeneID" id="66494277"/>
    <dbReference type="eggNOG" id="COG2848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08025">
        <property type="entry name" value="RNR_PFL_like_DUF711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01221">
        <property type="entry name" value="UPF0210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007841">
        <property type="entry name" value="UPF0210"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37560">
        <property type="entry name" value="PTHR37560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05167">
        <property type="entry name" value="DUF711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO29706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="454" mass="47420" checksum="14DF1158D9053AEF" modified="2016-09-07" version="1">MINIFEVNETNKMIEQENLDVRTITMGISLLDCIDSDLAVLNEKIYKKITTCAKDLVSTGEAISGEYGIPIVNKRISVTPIALIGGAACKTKEDFVTIAETLDKAAKVVGVNFIGGYSALVSKGMTPAERLLIESIPQAMAKTERVCSSVNVGSTRTGINMDAVKLMGEIVLETAKATKDQDSLGCAKLVVFCNAPDDNPFMAGAFHGVTEADTIINVGVSGPGVVKTALEQVRGKDFETLCEMIKRTAFKVTRVGQLVAQEASRRLGVKFGIVDLSLAPTPAIGDSVAEILEEIGLEHAGAPGTTAALALLNDQVKKGGVMASTAVGGLSGAFIPVSEDQGMIDAVNAGALTLEKLEAMTCVCSVGLDMIAIPGDTKASTIAGIIADESAIGMVNQKTTAVRLIPVIGKGVGEVVEFGGLLGYAPIMPVNQFSCDAFVQRGGRIPAPIHSFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E0I2</accession>
    <name>A0A174E0I2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_00137</name>
        <name evidence="1" type="ORF">ERS852478_02400</name>
        <name evidence="2" type="ORF">GT712_04460</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381482.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29969">
        <property type="protein sequence ID" value="CUO29969"/>
        <property type="gene ID" value="ERS852478_02400"/>
    </dbReference>
    <dbReference type="GeneID" id="66494287"/>
    <dbReference type="eggNOG" id="ENOG50342MV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO29969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS88364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="71" mass="8557" checksum="E54E1CA5701722DB" modified="2016-09-07" version="1">MIKYEYETGMCKQLHYNGLWSVQYEGVPGHFKKVKMVCPCIRDECDQDCEVFRNIPEIKAADQEWHMRDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E209</accession>
    <name>A0A174E209_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6-phosphogluconolactonase</fullName>
            <ecNumber evidence="5">3.1.1.31</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Beta-propeller fold lactonase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pgl</name>
        <name evidence="5" type="ORF">BWLFYP14_00132</name>
        <name evidence="2" type="ORF">ERS852478_02405</name>
        <name evidence="4" type="ORF">GT712_04435</name>
        <name evidence="3" type="ORF">GT728_02020</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL32011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704751.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30110">
        <property type="protein sequence ID" value="CUO30110"/>
        <property type="gene ID" value="ERS852478_02405"/>
    </dbReference>
    <dbReference type="GeneID" id="66494292"/>
    <dbReference type="eggNOG" id="COG2706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO30110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="355" mass="39648" checksum="D19C7AE68DEF2AF0" modified="2016-09-07" version="1">MSEKKYVAYVGSYTHGSSRQGIHVYDVDVENGTLTERSSVEVSNASHMAVSKNGKYLYSIEDEGVAVFKRDKNGDLSRINSVNIDGMRGCFLSTDVDGKYLYVAGYHDGKVTVVHTHKDGRLGSLMDGVFHTGLGSVAERNFRPHVNCVRPTPDNKYLCAVDNGIDQVKIYRVNKLRNKLELVDILRCPRESGPRIIRFSDDGKFAYILFELSNEIRAYKYDGSGKVPAFELIQTIETSAKKDVHDTHNAASGLSLANDGKHLFCTTAGEDTVSMFERDEETGMLTRKFTLPISGEYPKDLVLLPDDKHLVLANHASNTLTTFTVDYEKNIIVMNGKPIKITEPNCIRIWPVPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E7B9</accession>
    <name>A0A174E7B9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2 family transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02153</name>
        <name evidence="2" type="ORF">ERS852478_02467</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993997.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32448">
        <property type="protein sequence ID" value="CUO32448"/>
        <property type="gene ID" value="ERS852478_02467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO32448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="242" mass="27398" checksum="B4FAE5F93103F463" modified="2016-09-07" version="1">MLGETKRMFFNKNFLAAWLIACISIAIGQTYPSLKKALTCGTFISILEGSLKSQAVSFAIPVAAVLPWSDSILQEYKSGFLKEILPRTTRRQYIEGKVFSIMVSGFMVWTLSILTVLFINFIVFYPLEIKGAIQKDALLDLLMKAFRTGLIGSIISTFGGSCGILWDSAYMTYGIPFVSFYFGIILHDRYFKNQIWFYPVEWILADENWGPDKIGVWLFLLLFLLVMLGILGGVLYGRLEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EPL6</accession>
    <name>A0A174EPL6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stage II sporulation protein Q</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spoIIQ</name>
        <name evidence="4" type="ORF">ERS852478_02681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO39421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39421">
        <property type="protein sequence ID" value="CUO39421"/>
        <property type="gene ID" value="ERS852478_02681"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020946" evidence="2">
        <location>
            <begin position="35"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="198"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO39421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="297" mass="32028" checksum="ADEFBBDC2132A839" modified="2016-09-07" version="1">MMNNKVTRIIANSVGLAAVAALGITVYQLGTSPVKEKTPEEKTENVGESTQDTEEQLSEDAGTNHVESENQWISDDGEDLDDTKVTFQKQGMYGETAQNTVDNNESDNTADVDKTDSAVNSQQAEESSVNANMKSQTISEDQADEATDVSASALNLATVNFSEDTLMEWPVNGNVLLDYSMDQTTYFPTLDQYKLSPAIAVGAVEGAPVVAAVNGKVYSIEQNAQTGTTLTMELGNGYQAVYGQLTDLTVSEGDTIKKGTTIGYIAQPTKYYSTEGTNLYFAMKKDGKPIDPIEYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EQ53</accession>
    <name>A0A174EQ53_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized sugar isomerase yihS</fullName>
            <ecNumber evidence="1">5.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yihS</name>
        <name evidence="1" type="ORF">ERS852478_02661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579004.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38798">
        <property type="protein sequence ID" value="CUO38798"/>
        <property type="gene ID" value="ERS852478_02661"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO38798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="418" mass="47999" checksum="FD2E79AEB2268FD5" modified="2016-09-07" version="1">MENSGKKYQIDTEENKMFLGELQKNLLNFGKGFLSPGGSAYFLGDDGTPWKDRNRETWITCRMVHVYSMGIMLGDKESPALVHGAVHGLLEELKDRENGGWYPGITPDNKFLPDKQCYAHAFVLLAASSALLAGEKDAETLLKDALELFDKRFWDEKQGLTYDTWNTEFTVLDDYRGLNANMHTVEAFLAVADAIKEEKYRIRAGRIIDHVIGWASANDWRIPEHFTKEWKADLDCNKECPADRFKPYGATPGHGIEWARLIVQWAYSSYKDTPDSAEVYLKAAEKLYNRAVEDSWNVDGNPGIVYTTDWDGKPVVHDRMHWTLAEAINTSAVLWHITHKQKYAKDYEEFMRYLDDKVLDHKNGSWFHQLDENNNVIGTVWPGKSDVYHAFQSTWIPYGTPYISIASDVKQYMEVCHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EYX2</accession>
    <name>A0A174EYX2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_00546</name>
        <name evidence="1" type="ORF">ERS852478_02756</name>
        <name evidence="2" type="ORF">GT728_09685</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000019">
        <property type="protein sequence ID" value="MZL33463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026650366.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41746">
        <property type="protein sequence ID" value="CUO41746"/>
        <property type="gene ID" value="ERS852478_02756"/>
    </dbReference>
    <dbReference type="GeneID" id="66493293"/>
    <dbReference type="eggNOG" id="ENOG503321V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO41746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL33463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX62768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="76" mass="8863" checksum="8ECC906CD234BD12" modified="2016-09-07" version="1">MRQEKFKMERQGLINVGDEIEISEYQSFMNYSYIIEPAVAMSGCYPNAERIRSRKGIVKNIEHTPRGFIVTAEFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F661</accession>
    <name>A0A174F661_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional repressor yvoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yvoA_3</name>
        <name evidence="2" type="ORF">ERS852478_02873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379822.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45554">
        <property type="protein sequence ID" value="CUO45554"/>
        <property type="gene ID" value="ERS852478_02873"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO45554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="123" mass="14072" checksum="07942F78F0E41164" modified="2016-09-07" version="1">MHIIINNSSMVPIYEQIIDQIKSAIIRGELQPDTVLPSVRSLSKELKISALTVKKAYDNLEEEGFTVTVHGKGTYVAATNKNLMREEQLKEVEYDLEQAIMKGRRCGLNDEEIRNLFEMIMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F6D2</accession>
    <name>A0A174F6D2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gcp</name>
        <name evidence="6 10" type="synonym">tsaD</name>
        <name evidence="12" type="ORF">BWLFYP14_02878</name>
        <name evidence="8" type="ORF">ERS852478_02831</name>
        <name evidence="9" type="ORF">ERS852523_03587</name>
        <name evidence="11" type="ORF">GT712_17635</name>
        <name evidence="10" type="ORF">GT728_14515</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000056">
        <property type="protein sequence ID" value="CUQ00550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000038">
        <property type="protein sequence ID" value="MZL34380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000052">
        <property type="protein sequence ID" value="MZS90830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000064">
        <property type="protein sequence ID" value="VUX66501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705876.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000066_gene3219"/>
    <dbReference type="EnsemblBacteria" id="CUO44458">
        <property type="protein sequence ID" value="CUO44458"/>
        <property type="gene ID" value="ERS852478_02831"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ00550">
        <property type="protein sequence ID" value="CUQ00550"/>
        <property type="gene ID" value="ERS852523_03587"/>
    </dbReference>
    <dbReference type="GeneID" id="66494778"/>
    <dbReference type="eggNOG" id="COG0533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="7">
        <location>
            <begin position="26"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="137"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO44458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUQ00550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL34380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS90830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX66501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="339" mass="36267" checksum="98B1113653D80CD6" modified="2016-09-07" version="1">MKDTLILAIESSCDETAASVVKNGRTILSNVISSQIALHTLYGGVVPEIASRKHIEKINQVIEQALADADVTLDDLDAIGVTYGPGLVGALLVGVAEAKAIAYAKKLPLVGVHHIEGHVSANYIEHPDLEPPFLCLIVSGGHTHLVIVKDYGEFEILGRTRDDAAGEAFDKVARAIGLGYPGGPKVDKLSKEGNPNAIEFPKAKIGDCPYDFSFSGVKSAVLNYINHAQMTGEEINRADLAASFQKAVVDVLVEHTMLAAKDYGMTKIAIAGGVASNGTLRAAMEEACKKNNYSFYRPSPIFCTDNAAMIGVAAYYEYIKGTRHGWDLNAVPNLKLGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FAB5</accession>
    <name>A0A174FAB5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Probable ABC transporter-binding protein DR_1438</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02857</name>
        <name evidence="4" type="ORF">GT712_16340</name>
        <name evidence="3" type="ORF">GT728_14415</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000038">
        <property type="protein sequence ID" value="MZL34360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000043">
        <property type="protein sequence ID" value="MZS90586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45085">
        <property type="protein sequence ID" value="CUO45085"/>
        <property type="gene ID" value="ERS852478_02857"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252888" evidence="1">
        <location>
            <begin position="30"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO45085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="416" mass="45562" checksum="90B931F1F8A33608" modified="2016-09-07" version="1">MGMKKKMLSATLCAVMVGSLAAPAFTVQAADDTLVYWSMWEATEPQGQVIQEAVDAYTEQTGVKVDLQFKGRTGNREALQPALDGGTQIDIFDEDIDRVNGMYGKYLLDLEDLAKDNDYEATANAGLMAACRDAGGGTLKTIPYQPNVFAFFYNKDLFEQAGITEEPKTWDEFKDVCQKLKDAGITPMTMDDAYATCVIGYHLARLVGEDKVKEIVTEGEWDDPAVLQMAQDIEELASNGYYSEMVGSNVWPAGQNTELALGTAAMYLNGSWLPNEVKEMAGPDFHWGCFAYPALTDGANGIETNNFGAQVFGINKDTKLAKEAFDLITFLTKGEYDQKLADETVGIPADTTNTEWPAMVECAKPVIEQSTNRFTWACGVESNVDMTPVIKENFIKLMAGSITADEFVSTMQDAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FAM0</accession>
    <name>A0A174FAM0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45856">
        <property type="protein sequence ID" value="CUO45856"/>
        <property type="gene ID" value="ERS852478_02884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO45856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="75" mass="8891" checksum="7BB169D2F696568D" modified="2016-09-07" version="1">MLLKPQTPEMLLEEKQFQEQVYAVVMKLPEKQAKRIYARYYLGMTVNEIAEVEGVDPSRVRDSIRRGLKQLVKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FF83</accession>
    <name>A0A174FF83_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201000.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46785">
        <property type="protein sequence ID" value="CUO46785"/>
        <property type="gene ID" value="ERS852478_02910"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO46785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="423" mass="49527" checksum="6F60C170402C84E3" modified="2016-09-07" version="1">MQEYRKLLCVNKIRETKRLIENMLIPILSLVVAAAVVGYQIVINFFPIIRKINACNLRICYLVFGFLILYSFGVCFINVKPAIIIKPASLFFIREKRIRQMISIKYIGLTLKDIIFSIILSACINGIHLNRNFLFILLIIFLLLNTTNLMRWKIYHANQRRDIGIWLLFSIILVISLKYFFMCIIIDIGIWMYMLVYDFGVLEINALKYEDEMQFLEKVRIAQNFNNTVLLDQYAKEKMVRYLQRKNKVSNFLYYFPLIWKAQISIYRLGRNWIIMGMILFTICLGIYKMPFYWTLPFLQQEEIRYMLLLGSIFAVFRLTLRSMVQQLDSILEKATDGLFIPISENRIVKQFMVIPITIVCGEGIIMAFVVNSSIAQILLGCAILICATVLNLWLEVKYKNFLVKKDFILSIAVFLGALILTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FIL8</accession>
    <name>A0A174FIL8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">raiA</name>
        <name evidence="2" type="synonym">hpf</name>
        <name evidence="9" type="ORF">BWLFYP14_03578</name>
        <name evidence="5" type="ORF">ERS852478_02972</name>
        <name evidence="6" type="ORF">ERS852523_01478</name>
        <name evidence="8" type="ORF">GT712_01765</name>
        <name evidence="7" type="ORF">GT728_07400</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP39513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000013">
        <property type="protein sequence ID" value="MZL33031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706266.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000125_gene3810"/>
    <dbReference type="EnsemblBacteria" id="CUO48778">
        <property type="protein sequence ID" value="CUO48778"/>
        <property type="gene ID" value="ERS852478_02972"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP39513">
        <property type="protein sequence ID" value="CUP39513"/>
        <property type="gene ID" value="ERS852523_01478"/>
    </dbReference>
    <dbReference type="GeneID" id="66493673"/>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="4">
        <location>
            <begin position="115"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO48778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP39513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS87850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX67303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="175" mass="20385" checksum="5DA3F6C5C5EAB2ED" modified="2016-09-07" version="1">MKFIISGKNITVTEGLKTAVQDKLSKLERYFTPDTEVVVTLSVEKERQKIEVTIPVKGNIIRSEQVSNDMYVSIDLVEEVIERQLRKYKNKIVDKQQAAANFQKAYLDKDYDEDEEVKIIRTKKFGIKPMYPEDACVQMELLGHNFFVFYNAETEQVNVVYKRKGNTYGLIEPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FIL9</accession>
    <name>A0A174FIL9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_03604</name>
        <name evidence="3" type="ORF">ERS852478_02946</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO47975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380025.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47975">
        <property type="protein sequence ID" value="CUO47975"/>
        <property type="gene ID" value="ERS852478_02946"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252916" evidence="2">
        <location>
            <begin position="24"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO47975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX67329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="172" mass="18684" checksum="2FF49E40C758478F" modified="2016-09-07" version="1">MRKIFAVLAALICCLSVWTSVPAAQAFTLDKEDGEYSIQVELEGGSGKASVTSPTLITVKNGEVTADIQWSSSNYDYMIVDGKKYLPVNEEGTNSEFQIPVTIMDESMPVIADTTAMGTPHEINYTLTFYSDSIGSKSQMPQEAAKRVVAVALVIIVGGGILNYFVNKRNRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FQ71</accession>
    <name>A0A174FQ71_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO52412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52412">
        <property type="protein sequence ID" value="CUO52412"/>
        <property type="gene ID" value="ERS852478_03080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="111"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO52412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="408" mass="47711" checksum="F2188DD999A77457" modified="2016-09-07" version="1">MAHIFLSQLKTVLNNCIDELEQIHFLFSRNPETDFTRKRKLTFKEYIQFMLLMQGKTVSNEILDFFSHFLSAPSKSAFTQQRYKLLPEGWDFLFHSFVTQCRSLSDDLYCGYRLLACDGSDVNIARNPSDERTFIHEGEKGYNAVHINALYDIMNKTYCDFHVQGKKKLHERAALNLMVDRYSDPAPSILMADCGYESFNTFAHLIRKNMKFVIRMKDIDSNGILSSYDLPDDESDTRIKTTLTRRHTKETVGNPDIYTILQPSTDFDFPDEKCRYYDISSRIVRIRLENGSYICIATNLSKEEFSLKDIKKLYKMRWSEETSFRELKYTIGLVNWHSSKYDRILQEIAARMLLYNFCELVTSHAVIQTAENVKHVYKINFATAVNICRAYLKNGGDETEIMLLIQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FYB2</accession>
    <name>A0A174FYB2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conjugal transfer coupling protein TraG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_03121</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VirD4/TraG family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201169.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53826">
        <property type="protein sequence ID" value="CUO53826"/>
        <property type="gene ID" value="ERS852478_03121"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003688">
        <property type="entry name" value="TraG/VirD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02534">
        <property type="entry name" value="T4SS-DNA_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO53826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="596" mass="67887" checksum="711B391070DEFD35" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FYX7</accession>
    <name>A0A174FYX7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_00680</name>
        <name evidence="2" type="ORF">ERS852478_03143</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO54617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000015">
        <property type="protein sequence ID" value="VUX62931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54617">
        <property type="protein sequence ID" value="CUO54617"/>
        <property type="gene ID" value="ERS852478_03143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="55"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO54617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX62931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="111" mass="13031" checksum="F1B96BD50D5FD93F" modified="2016-09-07" version="1">METIRAAERAEAAYERKMYRYKAQYSLDCENGIENAVLLKPQTPEMLLEEKQFQEQVYAAVMKLPEKQAKRIYARYYLGMTVNEIAEVEGVDPSRVRDSIRRGLKQLAKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FZ34</accession>
    <name>A0A174FZ34_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5348 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53879">
        <property type="protein sequence ID" value="CUO53879"/>
        <property type="gene ID" value="ERS852478_03123"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RXG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035255">
        <property type="entry name" value="DUF5348"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17295">
        <property type="entry name" value="DUF5348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5348" evidence="1">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO53879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="73" mass="8516" checksum="F8DD0A3618617F3D" modified="2016-09-07" version="1">MMTQKTGALIFDETADRYDIRFDLNDYYGGLHCGDCMEVFVRGKWKPTRMEYGDNWYLVGIRAADLSGLRVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FZX3</accession>
    <name>A0A174FZX3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized ACR, YkgG family COG1556</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380870.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55793">
        <property type="protein sequence ID" value="CUO55793"/>
        <property type="gene ID" value="ERS852478_03181"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="15"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO55793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="208" mass="22796" checksum="94037C956986C511" modified="2016-09-07" version="1">MDANMKKRNELLAKTVIKGLESRNMSGYYAQDKEAALKQALELIPNGSTIAMGGCMSAHEIGLVKALQDGDYNYIDRAKLEPREGLMAAYDADFFLSSANAVTDDGVLVNIDGNSNRVSCIAQGPKKVIFIVGINKVCPDLDSAMKRARNVAATANAQRFDIKTPCKETGKCFNCKSPDTICCQFLITRYSRHKDRIHVILVNDTLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G2G3</accession>
    <name>A0A174G2G3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Homocysteine S-methyltransferase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Methionine synthase</fullName>
            <ecNumber evidence="6">2.1.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">metH_4</name>
        <name evidence="9" type="synonym">yitJ_2</name>
        <name evidence="9" type="ORF">BWLFYP14_02769</name>
        <name evidence="6" type="ORF">ERS852478_03185</name>
        <name evidence="8" type="ORF">GT712_14495</name>
        <name evidence="7" type="ORF">GT728_04460</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">BIOML-A1</strain>
            <strain evidence="8 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000007">
        <property type="protein sequence ID" value="MZL32471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000032">
        <property type="protein sequence ID" value="MZS90246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381265.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56171">
        <property type="protein sequence ID" value="CUO56171"/>
        <property type="gene ID" value="ERS852478_03185"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="Betaine-hCys_S-MeTrfase_BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO56171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL32471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS90246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="290" mass="30653" checksum="A6C22E6A9E4B588A" modified="2016-09-07" version="1">MTREEFQKLTQDVVLLDGATGSNLMAAGMPRGICTEAWIMEHKEVLQNLQKAYVEAGSQIVYAPTFGGNRYSLGLHGLQDKLAEMNHALVNISREAVGHKVYVAGDITTTGKMMEPAGDLTYEMAYETYCEQIKVLEDAGVDLIAAETMINIEETLAALDAAASVSSLPVMCTMTVEADGSIFSGGNAVEAAIALEGAGAVAVGINCSVGPDQLVSVVRNIKENVSIPVIAKPNAGMPTIDDQGNAIYSMDAKSFAEHMKVLIENGASVVGGCCGTTPEFIREISRSLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G433</accession>
    <name>A0A174G433_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
            <ecNumber evidence="1">3.1.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">dtd</name>
        <name evidence="2" type="ORF">ERS852478_03178</name>
        <name evidence="3" type="ORF">ERS852523_03503</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EC" id="3.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000053">
        <property type="protein sequence ID" value="CUP98324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706007.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000189_gene1037"/>
    <dbReference type="EnsemblBacteria" id="CUO55620">
        <property type="protein sequence ID" value="CUO55620"/>
        <property type="gene ID" value="ERS852478_03178"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP98324">
        <property type="protein sequence ID" value="CUP98324"/>
        <property type="gene ID" value="ERS852523_03503"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1490">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO55620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP98324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="148" mass="16579" checksum="65C4FFE1A588BE91" modified="2016-09-07" version="1">MRFVIQRVMHSKVTINGEVRGQIGKGFMVLIGVGEEDTVEIADKMIHKMVNMRIFEDENGKTNLGLKEVGGSLLLISQFTLYADCKRGNRPSFIRAGAPDMAENLYKYIIARCKEHIDIVEQGEFGADMKVELVNDGPFTVILDSNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G676</accession>
    <name>A0A174G676_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methionine import ATP-binding protein MetN</fullName>
            <ecNumber evidence="8">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">metN_2</name>
        <name evidence="8" type="ORF">ERS852478_03244</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380854.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57953">
        <property type="protein sequence ID" value="CUO57953"/>
        <property type="gene ID" value="ERS852478_03244"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033232">
        <property type="term" value="F:ABC-type D-methionine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03258">
        <property type="entry name" value="ABC_MetN_methionine_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026253">
        <property type="entry name" value="ABC_MetN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041701">
        <property type="entry name" value="MetN_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43166:SF5">
        <property type="entry name" value="PTHR43166:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="4"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO57953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="351" mass="38379" checksum="FD93CB9AE1C207DF" modified="2016-09-07" version="1">MSGIVIEKVRKSFDTKDGVVEALKDVNLNIDSGDIYGIIGMSGAGKSTLVRCMNFLEVPTEGRVLIDGKALGDLTEKELRKQREEIGMIFQHFNLLMQKSVIDNVCFPLYIKGKKKAEARKRAAELLEIVGLGDRQNAYPAQLSGGQKQRVAIARALASDPKILLCDEATSALDPQTTSSILELLKKINKQFGITIVIITHQMSVVREICTHVAIMYEGEVVEKGLVADIFANPQSEVAKELIRKDTGSDIDADSRLDAGREKGQAEIKSGEKIRIVFSENSAFEPVIANLILTFGEPVNILKADTKNVGGVAKGEMILEFMEGSTRTEMMKQYLKEKGLAIGEVTGYVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G6U6</accession>
    <name>A0A174G6U6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisH1</name>
        <name evidence="8" type="synonym">hisH</name>
        <name evidence="12" type="ORF">BWLFYP14_02235</name>
        <name evidence="11" type="ORF">ERS852478_03209</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703502.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56848">
        <property type="protein sequence ID" value="CUO56848"/>
        <property type="gene ID" value="ERS852478_03209"/>
    </dbReference>
    <dbReference type="GeneID" id="66493898"/>
    <dbReference type="eggNOG" id="COG0118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Class_I_gatase-like"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IMP_synth_hisH"/>
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    </dbReference>
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        <location>
            <position position="183"/>
        </location>
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    <feature type="active site" evidence="8 9">
        <location>
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            <dbReference type="EMBL" id="CUO56848.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VUX65869.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="212" mass="23441" checksum="E5E568F24ED44692" modified="2016-09-07" version="1">MIAIIDYDAGNIKSVEKALHYLGEETTVTRDPQTLLNADKVILPGVGSFGQAMENLHTYGLVPVIHEIVEKKTPFLGICLGLQLLFESSEETPGVEGLGILKGKIVKIPPAPGLKIPHMGWNSLHFQNNGRLFQGIPEQTYVYFVHSYYLQAEEPEIVKATTEYSTCIHASVEKDNVFACQFHPEKSSKWGLKILENFAAVGKDGNTEKEGK</sequence>
</entry>
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    <accession>A0A174G7D8</accession>
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            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="CUO57891.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GC28</accession>
    <name>A0A174GC28_9FIRM</name>
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        <submittedName>
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        <name evidence="2" type="ORF">ERS852478_03254</name>
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        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58450">
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            <begin position="6"/>
            <end position="22"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="EMBL" id="CUO58450.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="58" mass="6912" checksum="A038F6A1FFA59422" modified="2016-09-07" version="1">MFYIVFNFAMAVIMFLFGIWFYRSKGQASNFLSGDNMKSAEERKNMMKMLCVRHMGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GLV1</accession>
    <name>A0A174GLV1_9FIRM</name>
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        <submittedName>
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        <name evidence="1" type="ORF">ERS852478_03341</name>
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            <taxon>Bacteria</taxon>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO61425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="200" mass="22388" checksum="18836C44FEEB9206" modified="2016-09-07" version="1">MKTITRDEAFTLLKKYNKDPFHIQHALTVEAVMKWYANELGYGEDAEYWGIVGLLHDIDFELYPEEHCLKAPEMLREAGVGEDVIHSVVSHGYGITVGCGATIDVAPEHEMEKVLFAADELTGLIWAAALMRPSKSTKDMELKSLKKKYKSKGFAAGCSREVIERGADQLGWELQKLLTMTLQAMSDCEDEIKAEMDAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GS87</accession>
    <name>A0A174GS87_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02347</name>
        <name evidence="1" type="ORF">ERS852478_03477</name>
        <name evidence="3" type="ORF">GT712_16540</name>
        <name evidence="2" type="ORF">GT728_16065</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">BIOML-A1</strain>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_WWVQ01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65562">
        <property type="protein sequence ID" value="CUO65562"/>
        <property type="gene ID" value="ERS852478_03477"/>
    </dbReference>
    <dbReference type="GeneID" id="66493929"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO65562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL34667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="142" mass="16227" checksum="01EB6CA3D902136B" modified="2016-09-07" version="1">MKKKIIAVISGTAILIIAAGSIYGKFESSHKEGEPDVVGTFSVNRDENITVVANREDIEDREAFARKLLQMYKDDSFHSTKFSTDRGYATSIDMHIYLWKEDIEDGESVMTAEYRPVEYGKDYDIVNNPDKFQLYIDGKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GVK5</accession>
    <name>A0A174GVK5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thermostable beta-glucosidase B</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bglB_6</name>
        <name evidence="3" type="ORF">ERS852478_03461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201413.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65148">
        <property type="protein sequence ID" value="CUO65148"/>
        <property type="gene ID" value="ERS852478_03461"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="2">
        <location>
            <begin position="581"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO65148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="761" mass="83984" checksum="057D260377AB07C3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GY64</accession>
    <name>A0A174GY64_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02341</name>
        <name evidence="1" type="ORF">ERS852478_03472</name>
        <name evidence="3" type="ORF">GT712_16570</name>
        <name evidence="2" type="ORF">GT728_16095</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">BIOML-A1</strain>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708201.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65435">
        <property type="protein sequence ID" value="CUO65435"/>
        <property type="gene ID" value="ERS852478_03472"/>
    </dbReference>
    <dbReference type="GeneID" id="66493935"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO65435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL34673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="79" mass="9345" checksum="57651F7EB577C8D5" modified="2016-09-07" version="1">MNKVYVDVVAEFRKDGRLVPIFFTWEDGRKYSIDRILKIERCASRKAGGVGVMYTCMIQGQESHLFYEVDKWFMERKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H4L1</accession>
    <name>A0A174H4L1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201440.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68276">
        <property type="protein sequence ID" value="CUO68276"/>
        <property type="gene ID" value="ERS852478_03566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO68276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="85" mass="9907" checksum="C7EA1AB8D9D3FB78" modified="2016-09-07" version="1">MDNFQEQMEEIKQLKAEQALHRKQLEENRQRALAKRNQTKHLVTLGKIVDKLLPEDAAYQSEDDILEMLKDKLCSASDNNSHEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HA93</accession>
    <name>A0A174HA93_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding domain, excisionase family</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Excisionase family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03623</name>
        <name evidence="3" type="ORF">GT712_01635</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO70030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004843519.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70030">
        <property type="protein sequence ID" value="CUO70030"/>
        <property type="gene ID" value="ERS852478_03623"/>
    </dbReference>
    <dbReference type="GeneID" id="60301323"/>
    <dbReference type="GeneID" id="61435331"/>
    <dbReference type="GeneID" id="67480436"/>
    <dbReference type="eggNOG" id="ENOG5032TVS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038148">
        <property type="entry name" value="Tn1545/Tn916_Xis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO70030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS87826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="76" mass="8642" checksum="5C9FB3DC18941E9C" modified="2016-09-07" version="1">MTQRKIALSIEEAADYTGIGRNTLRQLVEWKKLPVLKVGRKVLIKTDILEMFMEANEGRDLRDRGNVKAVTRTAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HBH2</accession>
    <name>A0A174HBH2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381445.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70726">
        <property type="protein sequence ID" value="CUO70726"/>
        <property type="gene ID" value="ERS852478_03644"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO70726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="269" mass="30321" checksum="C759293857342DC0" modified="2016-09-07" version="1">MNRKAVFFDADGTLCDMEKGVPQSTKEALKKLRENGHDAWLCTGRSRAFVSRYLEELPFTGMISACGATIEKDGERLFNKEMPPEVAKKSVEILRRYGLVPVMEGADFMYYDKDEYNTDVNWYTDLITESLGPKWRPIRGNEDCMRINKISAKMIKGCDAEAACRELSEYYDIIRHESGSGIAGTTIELVPKGFNKAVGISAVCRLFDVPWEDTIVFGDSNNDLAMFEYAAVKVAMGNSSEKIKALADHITQDMFHYGIRNGLEYLKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HG83</accession>
    <name>A0A174HG83_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO72019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201493.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72019">
        <property type="protein sequence ID" value="CUO72019"/>
        <property type="gene ID" value="ERS852478_03689"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO72019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="74" mass="8266" checksum="7C3A377BBE55301B" modified="2016-09-07" version="1">MIGLKKRDIKKALKAGAKAGSVSFADVRADIEATIDEAMNSTDPEVQANFKKYFGNKRPTPEEYIYKLTKKTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HRQ8</accession>
    <name>A0A174HRQ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM mobile pair system MarR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Regulator of autolytic activity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mgrA</name>
        <name evidence="2" type="ORF">ERS852478_03827</name>
        <name evidence="4" type="ORF">GT712_15340</name>
        <name evidence="3" type="ORF">GT728_15660</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000055">
        <property type="protein sequence ID" value="CUO76256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000045">
        <property type="protein sequence ID" value="MZL34592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000037">
        <property type="protein sequence ID" value="MZS90405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704238.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76256">
        <property type="protein sequence ID" value="CUO76256"/>
        <property type="gene ID" value="ERS852478_03827"/>
    </dbReference>
    <dbReference type="GeneID" id="66494473"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031011">
        <property type="entry name" value="Reg_MarR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04472">
        <property type="entry name" value="reg_rSAM_mob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO76256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="145" mass="16723" checksum="E67CC8837C341BA9" modified="2016-09-07" version="1">MEMNGGFLVTKIKQLGDRIFEKILSEKNIDAFNGAQGRILYVLWQKDGISIRSLSTKCGLAITSLTTMLERMENQGLISRVQSETDKRKTLLFLTEKAHALKGEYDSVSDEMGSIYYKGFSEEEIIRFEECLDRIRKNLEEWQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LYY3</accession>
    <name>A0A174LYY3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_01278</name>
        <name evidence="1" type="ORF">ERS852478_00896</name>
        <name evidence="2" type="ORF">ERS852523_01108</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000009">
        <property type="protein sequence ID" value="CUP28066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000023_gene1770"/>
    <dbReference type="EnsemblBacteria" id="CUN72433">
        <property type="protein sequence ID" value="CUN72433"/>
        <property type="gene ID" value="ERS852478_00896"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP28066">
        <property type="protein sequence ID" value="CUP28066"/>
        <property type="gene ID" value="ERS852523_01108"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN72433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP28066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX64189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="341" mass="39420" checksum="68EE7C26E8DE6478" modified="2016-09-07" version="1">MKRNIFAVCDLEVDYALNFMDYMNRKKNIPFEIQAFTSVENLIAYGKQTHIELLLISGRAMCREVRDLDIGKIIILSEGVHPPELDQYPSVYKYQSSSDVLREVMACYGAEKKTVADQIAVLKKTTEIIGIFSPLGRCLKTSFALTLGQILAKERAVLYLNMEEYSGFEELMGKGFAHNLSDLLYYVRQDNQNLLYKMNSMIQTINNLDYVPPVQMPADIRTTAWQDWERLFQMLILDSSYEVIVLDIGCGIDENFQLLDMCKKIYMPVLSDAVSQCKIAQFENLVRIWDYPQILEKTEKINPPFHMATCLSPAYVEQLMWSELGDYVRNLLRKESQKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MBN9</accession>
    <name>A0A174MBN9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Copper-sensing transcriptional repressor CsoR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Copper-sensitive operon repressor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Metal-sensing transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">csoR_2</name>
        <name evidence="5" type="synonym">csoR_1</name>
        <name evidence="5" type="ORF">BWLFYP14_00291</name>
        <name evidence="1" type="ORF">ERS852478_01693</name>
        <name evidence="2" type="ORF">ERS852523_01259</name>
        <name evidence="4" type="ORF">GT712_08805</name>
        <name evidence="3" type="ORF">GT728_04875</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP32561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707305.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2947"/>
    <dbReference type="EnsemblBacteria" id="CUO03845">
        <property type="protein sequence ID" value="CUO03845"/>
        <property type="gene ID" value="ERS852478_01693"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP32561">
        <property type="protein sequence ID" value="CUP32561"/>
        <property type="gene ID" value="ERS852523_01259"/>
    </dbReference>
    <dbReference type="GeneID" id="66496157"/>
    <dbReference type="eggNOG" id="COG1937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO03845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP32561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX67450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="115" mass="12887" checksum="93A39E072603060B" modified="2016-09-07" version="1">MAEEQKTHTHVLEDGTVVEHSHGEHGHHHSHAHTKAVLNRMSRAIGHMESIKRMIEDGRDCAEVLIQLSAVKSAINNTGKIILQDHIEHCIVDAVEHGDKEAIKELEVAIDRFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NTB1</accession>
    <name>A0A174NTB1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HlyD family secretion protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Putative membrane fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02604</name>
        <name evidence="3" type="ORF">ERS852478_00106</name>
        <name evidence="4" type="ORF">ERS852523_01884</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP51982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000020_gene120"/>
    <dbReference type="EnsemblBacteria" id="CUN43887">
        <property type="protein sequence ID" value="CUN43887"/>
        <property type="gene ID" value="ERS852478_00106"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP51982">
        <property type="protein sequence ID" value="CUP51982"/>
        <property type="gene ID" value="ERS852523_01884"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9F5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032681">
        <property type="entry name" value="HlyD_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12700">
        <property type="entry name" value="HlyD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN43887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP51982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="483" mass="53885" checksum="0F7259A3E11F1DC4" modified="2016-09-07" version="1">MSDNKSKKMPGILARLRMVVGLNIGTIMFGILFIYMAFSAILYFTTTHIESYQVTSGPLSRNETYTGLAIREESLCKADSSGYITYYAREGSKINASGAVYGLSDTKTASAPASLAPEELSKVRTDMMSFSKGFSSSKFNSTYSFKYELKGNILQYAESGNTSSAPLTSDEDGEGNDSGDNDKTADIYPGNQTICQSQSDGIVLYSMDNYEGKTVDAVKAEDFDQNSYHETDLKTSDKVKAGDDIYTIITDERWSLLIPLSDRQVEKLKDRSTIRVKFLKDDMTQNGDFSIITIDGDKYGQIDFNKGLIRYASDRFLDIELVTNTVVGLKIPLTSIVTKDFYVIPSRMATTQDNQTGFTLYEGKNKTTFKNVSIYASIDDSSVSKLAVDEAEQPQIYYVDKSSFKEGDALINTDTGEKYVIGETDTLEGVYCINKGYAVFRRIEILDENEEYAIVSKNTTYGLSRYDHIVRNADKVKEEDILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SLD0</accession>
    <name>A0A174SLD0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">engB</name>
        <name evidence="10" type="ORF">ERS852478_03169</name>
        <name evidence="11" type="ORF">ERS852523_03512</name>
        <name evidence="13" type="ORF">GT712_16120</name>
        <name evidence="12" type="ORF">GT728_16505</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">2789STDY5834863</strain>
            <strain evidence="11 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 17">BIOML-A1</strain>
            <strain evidence="13 16">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000053">
        <property type="protein sequence ID" value="CUP98544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000051">
        <property type="protein sequence ID" value="MZL34751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000041">
        <property type="protein sequence ID" value="MZS90544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705985.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000094_gene761"/>
    <dbReference type="EnsemblBacteria" id="CUO55319">
        <property type="protein sequence ID" value="CUO55319"/>
        <property type="gene ID" value="ERS852478_03169"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP98544">
        <property type="protein sequence ID" value="CUP98544"/>
        <property type="gene ID" value="ERS852523_03512"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0218">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0717">Septation</keyword>
    <feature type="domain" description="EngB-type G" evidence="9">
        <location>
            <begin position="22"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO55319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP98544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL34751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS90544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="201" mass="22476" checksum="F4070EE42352C337" modified="2016-09-07" version="1">MVIKNVSLDIVCGITSKLPDTNRPEVAFAGKSNVGKSSLINGLMNRKSLARTSAQPGKTQTINFYNINEAMYLVDLPGYGYAKVSQSEKEKWGKMIERYLHTSKNLKAVFLLIDIRHDPSANDKMMYDWILNNGYEPIIIATKLDKLKRSQVQKNIKAIKEGLKLSKDGIIIPFSAETKQGRDEIWALIDELTGLAATEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X1D8</accession>
    <name>A0A173X1D8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine synthase</fullName>
            <ecNumber evidence="7">4.2.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">thrC</name>
        <name evidence="10" type="ORF">BWLFYP14_02674</name>
        <name evidence="7" type="ORF">ERS852478_00177</name>
        <name evidence="8" type="ORF">ERS852523_00334</name>
        <name evidence="9" type="ORF">GT712_00570</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
            <strain evidence="8 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000003">
        <property type="protein sequence ID" value="CUP03887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381416.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000032_gene381"/>
    <dbReference type="EnsemblBacteria" id="CUN45679">
        <property type="protein sequence ID" value="CUN45679"/>
        <property type="gene ID" value="ERS852478_00177"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03887">
        <property type="protein sequence ID" value="CUP03887"/>
        <property type="gene ID" value="ERS852523_00334"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thr_synth_N" evidence="6">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="PALP" evidence="5">
        <location>
            <begin position="99"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN45679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP03887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS87620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX66302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="496" mass="54510" checksum="B415EBC2E5330446" modified="2016-09-07" version="1">MQVLYKSTRGKEETVTASMAILKGLSEDGGLFVPTEIPKLDVPMDELAKMSYQETAYEVMKCFLTDFTEEELKNCINNAYDEKFDTKEIAPLHEADGAYFLELYHGATIAFKDMALSILPHLMTTAAKKNQVKNEIVILTATSGDTGKAAMAGFADVPGTKIIVFYPKHGVSPIQEKQMVTQKGNNTYVVGITGNFDDAQTAVKKMFNDKELEAELDAAGYQFSSANSINIGRLVPQIVYYVYAYASLVRQGKIKDGQEINVVVPTGNFGNILAAYYAKQMGLPVHKLICASNDNKVLYDFFRTGTYDRKRDFILTTSPSMDILISSNLERLIYRIAGGDAKKCAELMQSLTAGGEYTITEDMKAQLADFYGNYCTEDETAKTIAEIFKDSHYVIDTHTAVAAGVYDKYVKDTNDTTPTVIASTASPYKFTRSVMEALGADTDGKDDFALADELSALSGVKLPQAVETIRTAPVLHNRVVDAPDMPKAVKDILGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X256</accession>
    <name>A0A173X256_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable succinyl-diaminopimelate desuccinylase</fullName>
            <ecNumber evidence="4 7">3.5.1.18</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Putative succinyl-diaminopimelate desuccinylase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">YgeY family selenium metabolism-linked hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dapE</name>
        <name evidence="7" type="ORF">BWLFYP14_02684</name>
        <name evidence="4" type="ORF">ERS852478_00188</name>
        <name evidence="5" type="ORF">ERS852523_00345</name>
        <name evidence="6" type="ORF">GT712_00520</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">2789STDY5834863</strain>
            <strain evidence="5 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.1.18" evidence="4 7"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000003">
        <property type="protein sequence ID" value="CUP04121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025581111.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000134_gene413"/>
    <dbReference type="EnsemblBacteria" id="CUN45949">
        <property type="protein sequence ID" value="CUN45949"/>
        <property type="gene ID" value="ERS852478_00188"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04121">
        <property type="protein sequence ID" value="CUP04121"/>
        <property type="gene ID" value="ERS852523_00345"/>
    </dbReference>
    <dbReference type="GeneID" id="66495836"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017706">
        <property type="entry name" value="Peptidase_M20/DapE_YgeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03526">
        <property type="entry name" value="selenium_YgeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="180"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN45949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP04121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS87611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="436" mass="48549" checksum="593158F291863E27" modified="2016-09-07" version="1">MDYAKINEAAMGYKDDMTKFLRDLVRIPGESCGEKGHIMRIKEEMEKVGFDKVQIDPMGNILGYMGTGKTLIGFDAHIDTVGIGNIKNWEFDPYEGFESDEEIGGRGTSDQMGGIVSAVYGAKIMKDLGLLNDKYQVLVTGTVQEEDCDGLCWQYIIHEDGVRPEFVVSTEPTDGGIYRGQRGRMEIRVDVKGVSCHGSAPERGDNAIYKMADILQDIRALNENDAADTTEIKGLVKMLDEKYNPEWEEARFLGRGTVTTSEIFFTSPSRCAVADSCSVSLDRRMTAGETWESCLDEIRALPAVQKYGDDVTVSMYEYNRPSYTDLVYPIECYFPTWVIPKDHKVTQALEEAYKGLYGEERLGNAETEGMRKARPLTDKWTFSTNGVTIMGRNSIPCIGFGPGAEAQAHAPNEKTWKIDLVRCAAVYAALPTAYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X5K4</accession>
    <name>A0A173X5K4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpfG_1</name>
        <name evidence="7" type="ORF">ERS852478_00223</name>
        <name evidence="8" type="ORF">GT728_05875</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381031.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46991">
        <property type="protein sequence ID" value="CUN46991"/>
        <property type="gene ID" value="ERS852478_00223"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="158"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="302"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="6">
        <location>
            <begin position="439"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN46991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL32746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="659" mass="77046" checksum="BE5A5C7914946F43" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X5W5</accession>
    <name>A0A173X5W5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA ligase</fullName>
            <ecNumber evidence="11">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">ligA</name>
        <name evidence="13" type="ORF">ERS852478_00230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN47182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199511.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN47182">
        <property type="protein sequence ID" value="CUN47182"/>
        <property type="gene ID" value="ERS852478_00230"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BRCT" evidence="12">
        <location>
            <begin position="571"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="11">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN47182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="652" mass="73159" checksum="DDD82DCA4F527832" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XE33</accession>
    <name>A0A173XE33_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059860.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49924">
        <property type="protein sequence ID" value="CUN49924"/>
        <property type="gene ID" value="ERS852478_00286"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN49924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="62" mass="7362" checksum="CCD029ECE0C7156A" modified="2016-09-07" version="1">MKRLVIKNKRKIWLWFLFIVLLILACRAAYVTGNKNMQIRDEAVEEQQVENVVGQDKVERLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XF68</accession>
    <name>A0A173XF68_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stage 0 sporulation protein A homolog</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">rpfC_1</name>
        <name evidence="12" type="ORF">ERS852478_00274</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49557">
        <property type="protein sequence ID" value="CUN49557"/>
        <property type="gene ID" value="ERS852478_00274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="350"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="596"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN49557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="725" mass="82514" checksum="336A1DCBEFA502A1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XLY6</accession>
    <name>A0A173XLY6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-dependent transcriptional activator malT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">malT</name>
        <name evidence="4" type="ORF">ERS852478_00383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199591.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52942">
        <property type="protein sequence ID" value="CUN52942"/>
        <property type="gene ID" value="ERS852478_00383"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2909">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="764"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN52942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="838" mass="95096" checksum="E22EC25C02A63514" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XM88</accession>
    <name>A0A173XM88_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52350">
        <property type="protein sequence ID" value="CUN52350"/>
        <property type="gene ID" value="ERS852478_00363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN52350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="82" mass="9612" checksum="2DDDC83539BF26AF" modified="2016-09-07" version="1">MRRKRLAPFGMWIVFEIVAVTLWLTKDNLFYLLNFSYIGTSITVGLLLFQFNYKHARRIRSTSGWFVYADLSGTYMPGKHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XR73</accession>
    <name>A0A173XR73_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF3791)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00400</name>
        <name evidence="2" type="ORF">ERS852523_01590</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000013">
        <property type="protein sequence ID" value="CUP42751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53426">
        <property type="protein sequence ID" value="CUN53426"/>
        <property type="gene ID" value="ERS852478_00400"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP42751">
        <property type="protein sequence ID" value="CUP42751"/>
        <property type="gene ID" value="ERS852523_01590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024269">
        <property type="entry name" value="DUF3791"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12668">
        <property type="entry name" value="DUF3791"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN53426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP42751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="164" mass="18986" checksum="1C58696600A43FFD" modified="2016-09-07" version="1">MMADEKIKNSNELEFAVFCIENVAAKLGVDTERVYQAFTQKDDILNGYIVPEYKVLHTQSREYIVDDLLDVMKERNVEITHSNKNDQNEHSSAMTANPILLQKKYSRVIECFAKQHGLSLDAALDFFYRSEVYQLIRDGVSDMHCMSDAYLADELEQEYSQNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XSW9</accession>
    <name>A0A173XSW9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199611.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54056">
        <property type="protein sequence ID" value="CUN54056"/>
        <property type="gene ID" value="ERS852478_00421"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50328T3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN54056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="340" mass="38048" checksum="5B7DBCFE6BFFC767" modified="2016-09-07" version="1">MSVRSQSAFLRKAGTLTVWLIIFCIYFLGVYNYVQIRNDTAVSVFLSAAYPDRKGAENILKQERKSEKPYDVCFYADAGLREISAKEGNRQAQAMTVYLKGNPAGYDWQAAALTEGDPDGCVIDGTTAWELFGNKVPGGQILFQGRTYTVRKVADWGQKILVFGAASADDTETELFYNRLFIRRRNGETEESTVNGFLMKYGLQGTVVSSALPKNAGLAALLLLPAVLSGSLWTEISREKKNYTVKDAEYWFCNLLYSVMAGTVVWLLFTHLTWPEGWIPSRWSDFGFWKEKVDQAVAEFKLYLMLPKTVSQTEGMILGGKTVCAGGGSCFLYLLWKVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y0F2</accession>
    <name>A0A173Y0F2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Malonyl-CoA O-methyltransferase BioC</fullName>
            <ecNumber evidence="2">2.1.1.197</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bioC</name>
        <name evidence="2" type="ORF">ERS852478_00491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.197" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199673.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57133">
        <property type="protein sequence ID" value="CUN57133"/>
        <property type="gene ID" value="ERS852478_00491"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102130">
        <property type="term" value="F:malonyl-CoA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="27"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN57133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="177" mass="20137" checksum="CB5D1DFD1830ACC9" modified="2016-09-07" version="1">MNRHPGGEEQTIHLLKRIELKKGMKALDLGAGEGETVRIMKAFGLNVQGVDLAPRSSEVQRGDFLDLQYAADSMDLCISQCAFFVSRDQKKAVSECWRVLKKGGFLLLSDLDPGNLLEIVKETGFTILCQEDQTALWREYYLDAIWNDSFCCEDHKLLQKEYKGRKIGYIMIVGRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y5B4</accession>
    <name>A0A173Y5B4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-arabinose isomerase</fullName>
            <ecNumber evidence="6">5.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">araA</name>
        <name evidence="11" type="ORF">BWLFYP14_02120</name>
        <name evidence="8" type="ORF">ERS852478_00520</name>
        <name evidence="10" type="ORF">GT712_12405</name>
        <name evidence="9" type="ORF">GT728_11370</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 15">BIOML-A1</strain>
            <strain evidence="10 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of L-arabinose to L-ribulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>beta-L-arabinopyranose = L-ribulose</text>
            <dbReference type="Rhea" id="RHEA:14821"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:40886"/>
            <dbReference type="EC" id="5.3.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the arabinose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000026">
        <property type="protein sequence ID" value="MZL33779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000024">
        <property type="protein sequence ID" value="MZS89847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000038">
        <property type="protein sequence ID" value="VUX65641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708151.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58135">
        <property type="protein sequence ID" value="CUN58135"/>
        <property type="gene ID" value="ERS852478_00520"/>
    </dbReference>
    <dbReference type="GeneID" id="66492760"/>
    <dbReference type="eggNOG" id="COG2160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008733">
        <property type="term" value="F:L-arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00519">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024664">
        <property type="entry name" value="Ara_Isoase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038583">
        <property type="entry name" value="AraA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003762">
        <property type="entry name" value="Lara_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38464">
        <property type="entry name" value="PTHR38464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11762">
        <property type="entry name" value="Arabinose_Iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02610">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001478">
        <property type="entry name" value="L-ara_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arabinose_Iso_C" evidence="7">
        <location>
            <begin position="366"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN58135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS89847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX65641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="499" mass="56416" checksum="6FC5021BAAEF04CA" modified="2016-09-07" version="1">MKTGRNYKFWFCTGSQDLYGDECLRKVAEHSRIIVEELNKSGVLPFELVWKPTLITNELIRKTFNEANADEDCAGVITWMHTFSPAKSWILGLKEYRKPLCHLHTQFNEEIPYDTIDMDFMNENQSAHGGREYGHIVTRMGIERKVIVGHWADKDVQERLASWMRTAVGIMESSHIRVCRVADNMRNVAVTEGDKVEAQIKFGWEVDAYPVNEIADYVKDVAKGDVDALVDEYYSKYDILLEGRDPEEFKRHVAVQAQIEIGFEKFLEEKNYQAIVTHFGDLGALKQLPGLAIQRLMEKGYGFGAEGDWKTAAMVRLMKIMTAGVKDAKGTSMMEDYTYNFVPGKEGILQSHMLEVCPSVADGKIGIKVCPLSMGDREDPARLVFTSKTGPGIATSLIDLGDRFRLIINDVECKKVEKPMPKLPVGSAFWTPQPNLKTGAEAWILAGGAHHTAFSYDLTAEQMGDWAAAMGIEAVYIDKDTNIRDFKNELRWNELAFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y6L5</accession>
    <name>A0A173Y6L5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoesterase</fullName>
            <ecNumber evidence="4">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_00527</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199694.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58368">
        <property type="protein sequence ID" value="CUN58368"/>
        <property type="gene ID" value="ERS852478_00527"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="5">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN58368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="159" mass="18032" checksum="8C9B7B4702703161" modified="2016-09-07" version="1">MKVLIVSDTHGQDENLEETVLREAPFDYLIHCGDVEGREIFIEALAECPCTIVAGNNDFFTDLPYEEEVTLEGHKILVTHGHHYFVSRDYDKLVGNAQAKGCKIAMYGHTHMPVIENEDGILVINPGSLTYPRQRGRRPSYAVMQIEEGKDPQVEIRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y6W9</accession>
    <name>A0A173Y6W9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fluoroquinolones export ATP-binding protein Rv2688c/MT2762</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_00550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199704.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58977">
        <property type="protein sequence ID" value="CUN58977"/>
        <property type="gene ID" value="ERS852478_00550"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN58977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="201" mass="22145" checksum="93BEBDCDB12BFA5A" modified="2016-09-07" version="1">MDNMAIIVRNVTKKFGNVTVLDNVSLQVKKGTICGIIGRNGSGKTVLFKCICGLLQINEGSILVDKKEIGAIIEEPGFLKQYSGKQNLRLLASMSGKENIDIEKVLKVVGLECAGRKKVGKYSMGMRQRLGIAQAIMENQSILILDEPMNGLDNKGVDEIRKLILDLKKEGRSIILASHNREDIQILCDQVYEMDNGKIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YCD8</accession>
    <name>A0A173YCD8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA utilization protein GntX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706142.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60877">
        <property type="protein sequence ID" value="CUN60877"/>
        <property type="gene ID" value="ERS852478_00607"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044005">
        <property type="entry name" value="DZR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18912">
        <property type="entry name" value="DZR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZR_2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="104"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN60877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="234" mass="27308" checksum="C32D2F9BEDCF0EA2" modified="2016-09-07" version="1">MKRFLNMVADIFYPRCCPVCQKILADQRRMICPECEKELRPIGHPRCYKCGKPIETGEYCRDCQKHRHMYEQGRGIFVYDGIMRRSVTRYKYYGCREYGDFYARAMYRYAQKELREWKPDLIVPVPVHRSKERQRGFNQAAYLAEKLGHYTGISTDVNIVQKVLKTKSQKKLNALQRRKNLEKAFCVTGDVRGKNILVIDDVYTTGSTIDAMAGCLKRKGAGNVYFLTVCIGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YGB1</accession>
    <name>A0A173YGB1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fe(3+) ions import ATP-binding protein FbpC</fullName>
            <ecNumber evidence="5">3.6.3.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fbpC_1</name>
        <name evidence="6" type="synonym">fbpC_2</name>
        <name evidence="5" type="ORF">ERS852478_00648</name>
        <name evidence="6" type="ORF">ERS852523_01774</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
            <strain evidence="6 8">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.30" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN62287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000016">
        <property type="protein sequence ID" value="CUP48895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055151037.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPB010000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000063_gene711"/>
    <dbReference type="EnsemblBacteria" id="CUN62287">
        <property type="protein sequence ID" value="CUN62287"/>
        <property type="gene ID" value="ERS852478_00648"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP48895">
        <property type="protein sequence ID" value="CUP48895"/>
        <property type="gene ID" value="ERS852523_01774"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN62287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP48895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="352" mass="39787" checksum="913BF640994DC6C9" modified="2016-09-07" version="1">MAISVDIEKKLHGFTLKVKLESDGSPMGILGASGSGKSMTLRCIAGIQTPDSGRIVVNDKVLFDSEKKINLKPQERKVGYLFQNYALFPTMTVEKNIACGYRGDKKQLKAKVADYIERYQLNGLEKRYPGQLSGGQQQRVALARMMIGEPEVILLDEPFSALDGYLKDIMQRDMQNFLNEYTGDMILVTHSRDEAYKFCGHLTILDSGQALTTGETKKLFERPGILQAARLTGCKNFSTVQKMGKHSIYAVDWDLMLQTKDVVPDDVTHVGIRGHWMKGASEGGENHMEVEVVEYIETTFEHQYLLKNKKGGDCQPVWWMCPKGNFEEDPRAKVPKYIHFPEEHLMLLKEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YM70</accession>
    <name>A0A173YM70_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="8">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">mraY</name>
        <name evidence="13" type="ORF">BWLFYP14_01802</name>
        <name evidence="9" type="ORF">ERS852478_00706</name>
        <name evidence="10" type="ORF">ERS852523_00638</name>
        <name evidence="12" type="ORF">GT712_03160</name>
        <name evidence="11" type="ORF">GT728_03765</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP12737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578129.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000016_gene3651"/>
    <dbReference type="EnsemblBacteria" id="CUN65222">
        <property type="protein sequence ID" value="CUN65222"/>
        <property type="gene ID" value="ERS852478_00706"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12737">
        <property type="protein sequence ID" value="CUP12737"/>
        <property type="gene ID" value="ERS852523_00638"/>
    </dbReference>
    <dbReference type="GeneID" id="66493483"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN65222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP12737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL32333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS88111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX65030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="318" mass="34697" checksum="6AABEEBFBA151294" modified="2016-09-07" version="1">MEFQVVIPVLISFAISVVLGPVIIPFLRRLKMGQTERTEGVQSHLKKAGTPTMGGVIFLIATAITALFYVGDYPKIIPVLFLTLGFGIIGFLDDYLKVVLKRSDGLLPWQKFLLQVVLTAIFVFYIVKYTDISLTMRIPFWSGHFLNLGWLAVPVLFFAVIGTVNGVNFTDGLDGLASSVTLIVAVFFTVVSIGMKSGIEPITGAVVGGLMGFLLFNVYPAKVFMGDTGSLALGGFVAGTAYVMQMPLFILIVGLIYLIEVLSVIIQVTYFKATHGKRIFKMAPIHHHFELCGWSETRVVAVFSVITAVMCMVALLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YR38</accession>
    <name>A0A173YR38_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensory histidine kinase DcuS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199773.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65535">
        <property type="protein sequence ID" value="CUN65535"/>
        <property type="gene ID" value="ERS852478_00717"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="2">
        <location>
            <begin position="326"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN65535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="435" mass="49325" checksum="99C1BDACE82DF332" modified="2016-09-07" version="1">MLYQDIPRIYTAIAEWGSCLVYLYILKKENMKSVHFLIGSLFMLAMQSIFLTLTGSVTEILWIPCMMIAAGMMYGFLMVGGNMKPLGAAYCCARAFVLAEFAASLQWQMVSIVQAWGNQSLGVEILITMVVFGGCFTIDIYLEKDLLKQNYLEQMTVKEVAAAAIMAVAIFAFSNLSFLNENAPFASRERADIFSIRTLVDFGGIAILHAYQSRISEYVAEKELSVMNVMLKSQYDQYRNYQDSLDLIQMKYHDLKHQITGLRAESDEEKRKKWIDSMEKEIAAFENISRTGNQVLDTILAAKIFHCRKNHIQITCVADGKLLDHMHVTDICSIFGNALDNAIEHVILIPDSEKRLIHLTVSAQKGFVFIKIENYCEAEISKNEEDLITTTKKDSKNHGFGLKSIRKAVEKYDGSVVFGVQQNWFELKILLPRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YRB2</accession>
    <name>A0A173YRB2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arginine-binding extracellular protein ArtP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">artP</name>
        <name evidence="4" type="ORF">ERS852478_00748</name>
        <name evidence="5" type="ORF">ERS852523_00595</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
            <strain evidence="5 7">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP11586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055149499.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000016_gene3691"/>
    <dbReference type="EnsemblBacteria" id="CUN66712">
        <property type="protein sequence ID" value="CUN66712"/>
        <property type="gene ID" value="ERS852478_00748"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11586">
        <property type="protein sequence ID" value="CUP11586"/>
        <property type="gene ID" value="ERS852523_00595"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014250740" evidence="2">
        <location>
            <begin position="27"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN66712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP11586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="262" mass="28319" checksum="2332D97BE6D066AD" modified="2016-09-07" version="1">MKDQKRFAALALSAVMVFSMAGSVSAAQKVESKDDLAGATIGVQLGTTGDLDASDYEKDGSTVERYSKGSEAVQALKAGQIDCVIIDSQPAQKFAENNDDLKILDEPFEEEEYAICLKKGNDELLDKINGALKELKEDGTIDSIMDNYIGEDAGKTPYESPEDVDRSNGTLVMATNAEFEPYEYHEGDDIVGIDADIAQAICDKLGYELKIEDMEFDSILPAVQSGKADFGAAGMTVTEDRKSSVDFTDTYADASQVIIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YSK8</accession>
    <name>A0A173YSK8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">hflX</name>
        <name evidence="9" type="ORF">ERS852478_00761</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199790.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67182">
        <property type="protein sequence ID" value="CUN67182"/>
        <property type="gene ID" value="ERS852478_00761"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="8">
        <location>
            <begin position="199"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="205"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="230"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="252"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="318"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="340"/>
            <end position="342"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN67182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="411" mass="45912" checksum="D3317A67CEB26199" modified="2016-09-07" version="1">MEEFGKLEERVVLVGVQTDDHDNVEESLDELKELASTAGAVTVGRIIQNRESVHPGTYIGKGKIEEVRALVYAMDATGIICDDELSPAQLNNLERELDCKVMDRTLLILDIFAARAITSEGKIQVELAQLRYRSARLVGLRESLSRLGGGIGTRGPGEKKLETDRRLIRTRISALKQELSQVEKHRELIRSSRARGNMKTAAIVGYTNAGKSTLLNTLTGSEVLSEDKLFATLDPTTRLLNLKDGQQILLTDTVGFIHKLPHHLVEAFKSTLEEAKYADYIIHVVDSSNPQAEMQMHVVYETLKELGVMGKKIITLFNKQDAPGACVLRDFKSDYTLKVSAKTGEGLADLNDLLEKLLAEEQIYVERLFPYQEAGKIQLIREYGQLISEEYTEEGIDVKARVPKEIYARVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YVU5</accession>
    <name>A0A173YVU5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="10">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">thrS</name>
        <name evidence="15" type="ORF">BWLFYP14_01748</name>
        <name evidence="13" type="ORF">ERS852478_00773</name>
        <name evidence="14" type="ORF">GT712_02895</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="14 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199791.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67660">
        <property type="protein sequence ID" value="CUN67660"/>
        <property type="gene ID" value="ERS852478_00773"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="12">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="11">
        <location>
            <begin position="266"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN67660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS88058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VUX64922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="653" mass="75002" checksum="5509054F4EC363D9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YYY7</accession>
    <name>A0A173YYY7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbon starvation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cstA</name>
        <name evidence="11" type="ORF">ERS852478_00804</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706394.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68807">
        <property type="protein sequence ID" value="CUN68807"/>
        <property type="gene ID" value="ERS852478_00804"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
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                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
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                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="gene ID" value="ERS852478_01008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN76009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL34197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX64377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="286" mass="33671" checksum="9401681F8A7EE040" modified="2016-09-07" version="1">MEKNKLNILNKIFSRSTFRNCFDNGYDKTYSQVVRRYVDNGTGKQNSELISQIYNVLREGYRNEYYYKNTLLNKLLLGIHSVNTTTALTEIPIAKSKADFVLINGKAVVYEIKTELDNFDRLENQINDYYKAFDHVAVVTCKENLQVLKKKIEMIGKPVGIYILQKRGTITTIQKPQAYSVELDAEILFKILRKQEYEEILFNKYKHLPDVSEFKYYSECKKMFLEIPLEEAYLSVLKLLKKRSQIIKDEFSKIPYELKFLAYFMNLKSDDYKKITKFLNESYGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZZ10</accession>
    <name>A0A173ZZ10_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lysozyme M1</fullName>
            <ecNumber evidence="5">3.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acm_2</name>
        <name evidence="5" type="ORF">ERS852478_01131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199932.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81277">
        <property type="protein sequence ID" value="CUN81277"/>
        <property type="gene ID" value="ERS852478_01131"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C51" evidence="4">
        <location>
            <begin position="261"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN81277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="477" mass="53516" checksum="420B07B35F99D653" modified="2016-09-07" version="1">MEIRGIDVSAWQGKIDWKTVADYGMGFAILRITEAGNVIDSYFEQNFSECRKYNIPVGAYKYSYAMTVAEIQSEARKVVEVLNGQKLRYPVWLDLEWNNQRSLGAEQIHKLAEAFEKIITAAGYKFGIYCNVDWYLNVICSHLKKYDFWIARYPASDNGTLQERLRPDFGVGWQYSSKAKIPGISGTVDRNIFYKDYNEAKDIKKENTVMTKSEAINVVLGIAEEEIGYLEKKNNSQLDSKTGNAGSANYTKYWRDIKPSYQGQPWCAAFISWCFMKAFGLDNAKKLLKHWPYVYCPTLGVLFVKNANPKVGDIVIFKYGGTFTHTGFVTKVTGDRFWTIEGNTSGASGIVANGGGVCQKSYYNSNLPGTKFCTPDYSIVLSADKDETDKTTNPEGGGYMFNPETVKAGDKNTSVLLLQEILRARGFKGKNGKALKLTWTADANTIYALKAYQESRKEVLEVDGICGSATWKDLIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A120</accession>
    <name>A0A174A120_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkaline shock protein 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026648456.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82271">
        <property type="protein sequence ID" value="CUN82271"/>
        <property type="gene ID" value="ERS852478_01161"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN82271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="128" mass="13656" checksum="B6B53D19EF55CBC0" modified="2016-09-07" version="1">MAEKRITYKIQDLGGIGEVQIADEVVAIIAGLAATEVDGVASMAGNITNELVSKLGMKNLSRGVKVTVLEGVVTVDLNLNIEYGKNILETSKKVQEKVKSSIENMTGLEVADVNIHIASVDMENEKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A537</accession>
    <name>A0A174A537_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 8">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">spo0A_1</name>
        <name evidence="14" type="synonym">spo0A_2</name>
        <name evidence="14" type="ORF">BWLFYP14_03062</name>
        <name evidence="12" type="ORF">ERS852478_01172</name>
        <name evidence="13" type="ORF">ERS852523_00493</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">2789STDY5834863</strain>
            <strain evidence="13 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8 9">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP08156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704085.1">
        <property type="nucleotide sequence ID" value="NZ_WWVE01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2130"/>
    <dbReference type="EnsemblBacteria" id="CUN82636">
        <property type="protein sequence ID" value="CUN82636"/>
        <property type="gene ID" value="ERS852478_01172"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08156">
        <property type="protein sequence ID" value="CUP08156"/>
        <property type="gene ID" value="ERS852523_00493"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051606">
        <property type="term" value="P:detection of stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042173">
        <property type="term" value="P:regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014879">
        <property type="entry name" value="Spo0A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012052">
        <property type="entry name" value="Spore_0_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08769">
        <property type="entry name" value="Spo0A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002937">
        <property type="entry name" value="Res_reg_Spo0A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02875">
        <property type="entry name" value="spore_0_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 8" id="KW-0749">Sporulation</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
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        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR002937"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN82636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUP08156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX66786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="268" mass="30553" checksum="E9C5030B258903C2" modified="2016-09-07" version="1">MEKLNVAIADDNEKMVEVLGQIIEEDKDLELVGKAHNGEEICNIIREKEPDVVVLDIIMPKMDGLAVMEKFANDKSLKKIPSFIVVSAVGQERITENAFNLGADYYILKPFDNQMLLNRIKHVRRAGERRIRQIGRQPERTEDNPVPVRNLETDVTNIIHEIGVPAHIKGYQYLRDAIILSVNDMEMLNSITKILYPTIAKKHQTTASRVERAIRHAIEVAWSRGKMDTIDELFGYTVSTGKGKPTNSEFIALIADKIRLEYKNRSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A7K8</accession>
    <name>A0A174A7K8_9FIRM</name>
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        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">ERS852478_01192</name>
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    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN83368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="157" mass="18350" checksum="C9D2ECFE50A41470" modified="2016-09-07" version="1">MEIRKASVQDLGQIMQVYDKARKFMRENGNAEQWGEDYPSAELIEHDIDKMYLCMSEGRIACVFYYAAEEDEDYKEINGKWLNEEPYGVVHRVASTGIVRGAASFCLDWAYAQTQNLRMDTYNDNIPMQKLLEKCGFQYCGSFERLGMDKWMAYQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AEM5</accession>
    <name>A0A174AEM5_9FIRM</name>
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        <submittedName>
            <fullName evidence="3">TnpV protein</fullName>
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    <gene>
        <name evidence="4" type="ORF">BWLFYP14_01377</name>
        <name evidence="1" type="ORF">ERS852478_01262</name>
        <name evidence="2" type="ORF">ERS852523_03166</name>
        <name evidence="3" type="ORF">GT712_09665</name>
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    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
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            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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    <reference evidence="1 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 5">2789STDY5834863</strain>
            <strain evidence="2 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
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            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CUN87032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="VUX64387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="TnpV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14198">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN87032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP89148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS89330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="124" mass="14297" checksum="FA854553490FE66D" modified="2016-09-07" version="1">MAKSLFEELGGKYERQGDYLIPCLTVPAEEEQAIGIWGQRHLDYLKQYRKVTYTNLLTSGRLNAYLADINRQAQERFERLIEGMKQAQGITEQLKAENALEWTGCLNNIRACAREIVEKEIIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174APS2</accession>
    <name>A0A174APS2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding/permease protein CydD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cydD</name>
        <name evidence="10" type="ORF">ERS852478_01367</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
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            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200035.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90592">
        <property type="protein sequence ID" value="CUN90592"/>
        <property type="gene ID" value="ERS852478_01367"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="332"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="365"/>
            <end position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN90592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="580" mass="64523" checksum="AE7A7BC4BF20AEAB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AR15</accession>
    <name>A0A174AR15_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribose import ATP-binding protein RbsA</fullName>
            <ecNumber evidence="5">3.6.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rbsA_2</name>
        <name evidence="5" type="ORF">ERS852478_01379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.17" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN91062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379837.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91062">
        <property type="protein sequence ID" value="CUN91062"/>
        <property type="gene ID" value="ERS852478_01379"/>
    </dbReference>
    <dbReference type="GeneID" id="66494871"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="251"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN91062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="497" mass="55607" checksum="F72D0BC8D740B8B8" modified="2016-09-07" version="1">MAHLLEMKNICKSFSGVSVLKNNHLELEAGEVHALLGENGAGKSTLIKILGGVYTKDSGQILVDGQEVEITGVESAKEHGIRIIHQELMLIPDMTISENIFIGQEPKTKAGTVDKKKMNEMAQGFLDSMHLDLKSTQFIRDLNIAQQQMVEIIRAISFGAKIIVMDEPTSSLTENEVDALFEAIKALKAKNVGIIYISHRMAELDAITDRITVMRDGEYIDTVVTKETTHDDLVALMVGRKLGDLYQKHENYSDDIILKVEKLASGKEVKNVDFELRRGEVLGFSGLVGSGRSETMECIFGLRHKDSGHIYIENKEVDIKNVKTAINAGIGLVPEDRKQSGIYPIQGIRFNATIEILDKFLKKGRYNRKKEIELARKYVDEVMQTKYSSIEQEIGKLSGGNQQKVIISRWLLVTEKILILDEPTRGIDVKTKSDIYHLIDDLTATGLSIIFISSEMPELINMCDRIVVMNQGHTTGILNRNEFNQEKIMAFATKEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AT68</accession>
    <name>A0A174AT68_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-ribose-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rbsB_1</name>
        <name evidence="3" type="ORF">ERS852478_01380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN91099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379838.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91099">
        <property type="protein sequence ID" value="CUN91099"/>
        <property type="gene ID" value="ERS852478_01380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017899" evidence="1">
        <location>
            <begin position="30"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="44"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN91099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="316" mass="33702" checksum="C1949528DF3DFCA7" modified="2016-09-07" version="1">MKRRLVTKLMMAAGVAAMAVTTIPASVFAAEDGGQTYGVTYWCESDFFKTVADSITEEAEADGNKTVVVDAQQDSAKQIQIIEDFIAQGVSAVFLNPVDKDAIEPALQKLDEAGIPVVNFDTSVSNLDLVGSYVATDNYQAGALCAEAMIEDFPDGGEIAVLDYPANNACNDREQGFLDTIEGKGFDVVATFDAEGTVEKGQTITSDIIQANPDIKAIFSINDQAGMGAYAALTTAGKEVYVYGVDGAPEAKKVIAKDNSIYRMTAAQSPITIGKECYKAAKTLIAGEKPEEFEVDVPAFAIDSSNIDEYLDADWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B1E9</accession>
    <name>A0A174B1E9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200086.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94049">
        <property type="protein sequence ID" value="CUN94049"/>
        <property type="gene ID" value="ERS852478_01439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN94049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="144" mass="15580" checksum="992EA58FB19FCA31" modified="2016-09-07" version="1">MKLVANKPCNLNGKKYFIGEEVPVEEVVDYASLVKMGLLSVIHDAVPADNLEECVAMVGEVSFTVPIVKGHETIDLDVTEPQMQDAVKTMQMNADAAIAHIRGDVEDNITLIVINALDSRKTVKEAAESKAKALIEQEESTGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B4G1</accession>
    <name>A0A174B4G1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200115.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95293">
        <property type="protein sequence ID" value="CUN95293"/>
        <property type="gene ID" value="ERS852478_01475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN95293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="88" mass="10606" checksum="3587CB81E821B111" modified="2016-09-07" version="1">MENMHLEPITKEILEMLAKYTFTPERNFGIYDNISISGDGEYIEFYGETVNKEPVYDKHGELMDYNYSVKSMARRYRRDKFSGEYFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BH55</accession>
    <name>A0A174BH55_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4366 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_01594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00371">
        <property type="protein sequence ID" value="CUO00371"/>
        <property type="gene ID" value="ERS852478_01594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025376">
        <property type="entry name" value="DUF4366"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14283">
        <property type="entry name" value="DUF4366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018489" description="DUF4366 domain-containing protein" evidence="3">
        <location>
            <begin position="45"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4366" evidence="4">
        <location>
            <begin position="294"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO00371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="474" mass="52292" checksum="631FB43F42266657" modified="2016-09-07" version="1">MMNLEKMKQKKRTITKSRVKKGLLAATTFLCLTTPLLQTQTAYAAENTTPAITIEKPDGWKQGETTIAVTVDASHMPEGFSIAKIEAKAGKDGSWQDVTGSGSITITGNQTVYVRVTDGEGKVYEQNRSIKCYDTEKPTLSASLTDGVLTIQGNDTVSGITAVTVNGTTYTDLKDGMLRVQLTQKDFTTKQIEITVTDGAGNTSEKYVLQNPYYEWAKKQAEKQKTSSDSNGAMATTTSADATGTEKTTTSPLPQDAQASEPTDAKGTVDDRTVTGIEKQLNKEGETAESVTKTATEGTKEFYTISTKSGKIFYLIIDNSKSQDNVYFLTEVSEKDLMNFTLSNSVTLPEVDTVYAEPEKKAEEEKPETTESSEKYKVEDDIQMPEDKSSFGTYLLIVLVAVGAAAGGYYFKVYKPKHEYDDEDEMEEDEDESEDSESEKREVDDADEQEESAEPEILRDEDFNDDVLEDEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BJ36</accession>
    <name>A0A174BJ36_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maff2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_017144663.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00209">
        <property type="protein sequence ID" value="CUO00209"/>
        <property type="gene ID" value="ERS852478_01589"/>
    </dbReference>
    <dbReference type="GeneID" id="64113506"/>
    <dbReference type="GeneID" id="67479054"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024272">
        <property type="entry name" value="MAFF-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12750">
        <property type="entry name" value="Maff2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO00209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="71" mass="7210" checksum="6A23E73CA2448AF8" modified="2016-09-07" version="1">MAFFSSAITTLKTLVVAIGAGLGVWGVVNLLEGYGNDNPGAKSQGIKQLMAGAGIMLLGTTLIPQLATLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BNU3</accession>
    <name>A0A174BNU3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator immR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">immR_5</name>
        <name evidence="2" type="ORF">ERS852478_01637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008688152.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000124.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01889">
        <property type="protein sequence ID" value="CUO01889"/>
        <property type="gene ID" value="ERS852478_01637"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO01889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="105" mass="11507" checksum="E67E463D216DB6D2" modified="2016-09-07" version="1">MDLKAVGQRIKSAREAKNLTQEELAALVNLSPTHVSVIERGLKVTKLDTFVAIANALDVSADTLLIDVVAHSVTGVTNELTEKIEKLPIKEQKKIIKVIHTLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BPM9</accession>
    <name>A0A174BPM9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Relaxase/Mobilisation nuclease domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057329.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01506">
        <property type="protein sequence ID" value="CUO01506"/>
        <property type="gene ID" value="ERS852478_01623"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005094">
        <property type="entry name" value="Endonuclease_MobA/VirD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03432">
        <property type="entry name" value="Relaxase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO01506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="459" mass="52953" checksum="0064DB958123A8D7" modified="2016-09-07" version="1">MAYLKIFPVKVTDKKALDYITNPDKTAEKLLVSSFGCSPETADLEFSMTREMAKKNGMDKGDNLAFHLIQSFKPGEVDAETAHRLGQQFADEVLKGKYEYVISTHVDKNHIHNHILFNAASFVDHHKYVSNKRSYHKLCRISNRICHENGLATSMPTGEKGKNYKENMEYHRGTSWKAKLRVAVDKAIWVSINYEEFLQKMQLAGYEIRQGKHLSFRAPEQKNFTYMKSLGSYYSEENVRIRLAKNRSKVKAPKHLSREARLYINISTYVTTGNREGFERWAKLNNLKEAARTFNYLSENNLLNYDDFRQHVSDIEASVKVADQRIAQINSELSTQKVIQKHCDSYRLCRKVIEDCKSAKNPKAYRTKHQAEYQLHDSLKKELQDLGVTKIPSPNKVQKLIENLESEQAATVREKQELQKKQKTLEIIQQNFSVLLDAPEINSDLLPAKRESVSVTRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C4J9</accession>
    <name>A0A174C4J9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS-dependent dihydroxyacetone kinase, ADP-binding subunit dhaL</fullName>
            <ecNumber evidence="2">2.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dhaL</name>
        <name evidence="2" type="ORF">ERS852478_01759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200231.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06688">
        <property type="protein sequence ID" value="CUO06688"/>
        <property type="gene ID" value="ERS852478_01759"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012737">
        <property type="entry name" value="DhaK_L_YcgS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02365">
        <property type="entry name" value="dha_L_ycgS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="7"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO06688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="211" mass="23251" checksum="4D76418C9B387B22" modified="2016-09-07" version="1">MEKIKTDVLKQMFLDGARLIIEKEPYLTEIDSVIGDGDHGEGMKRGCEALIKILETENYVYVDELCRAVSIELIKTMGGASGIIFGTMFLGGISSLGHQEYATAPQIADYFWNGEQAIERRGKARPGQKTMLDALYPACVEMKKAVLETSNIIEVLKRGYQAAVQGVADCRNFQSGIGRSRNFKEKTLGIPDPGAVSVSLWFQAFCLSVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C5J2</accession>
    <name>A0A174C5J2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetolactate synthase large subunit</fullName>
            <ecNumber evidence="6">2.2.1.6</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ilvB_2</name>
        <name evidence="6" type="ORF">ERS852478_01774</name>
        <name evidence="7" type="ORF">GT712_12050</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705384.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07145">
        <property type="protein sequence ID" value="CUO07145"/>
        <property type="gene ID" value="ERS852478_01774"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="3">
        <location>
            <begin position="197"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="395"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO07145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS89785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="580" mass="63941" checksum="DB73BB6821160B47" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CE60</accession>
    <name>A0A174CE60_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein, YkwD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO09985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053670.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09985">
        <property type="protein sequence ID" value="CUO09985"/>
        <property type="gene ID" value="ERS852478_01840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013378">
        <property type="entry name" value="Listeria/Bacterioides_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042229">
        <property type="entry name" value="Listeria/Bacterioides_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09479">
        <property type="entry name" value="Flg_new"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02543">
        <property type="entry name" value="List_Bact_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019101" evidence="2">
        <location>
            <begin position="27"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="29"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="130"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO09985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="464" mass="50754" checksum="8559995199EF127B" modified="2016-09-07" version="1">MKRKRFSFLTLLVLAIMLLMPTSIQAAVKPGTVKLSSIKAVDYNKINIKWKKVSGATNYIVYYKKAGSGKWIKVKTLDNKKSSYTHTSSTKYPIVVGQKYQYTIKAYNKNTKKSGNYNKKGLTTRTIPATVYGLGAGLTGDNTVNVSWNPAGGTTHYVVYRKANDSVLIKIATVSSKYTKYEDKNPVEGTTNTYFVVGYNSKLKVYGDGSTGVSIKVKKNITPTPEPGDGNNNYGDNDDDFDDPVDPIAMASEVLRLTNIERAKEGVQPLKYNKTLQDAAMIRAKEISVKFSHTRPNGTDSSTAGIDVGASVISGENIAMGYGSPEDVVDGWMNSSGHRAALLKPDFSYMGVGFYESANGMYYWTQEFTCTNPDAKGSITFDANGGLINGKDAYTIYGCAGQRIWLYDAPDGSSVTNIPTPTKDNYSFGGWFTTRNPGENRKPIKGVAYATNGDTLYAKWVPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CGH8</accession>
    <name>A0A174CGH8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200419.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11289">
        <property type="protein sequence ID" value="CUO11289"/>
        <property type="gene ID" value="ERS852478_01882"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO11289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="166" mass="19839" checksum="33EE6E8D7CF2600D" modified="2016-09-07" version="1">MWVDVVSLSTYCKRGSGNIAFNWIIVELFPRKIKPKYDTDPDYNRYLTWLTAHEDMEKQRDSGFHGEKFLVLCDLYDKNKNKFTTHTVIAKKYWEPMEAYRPMEIKNPIDPEWEYRIRAVKKVNAKQIRYIVGHEYELEEKIRKNGRPTLRILGIEDGAPQSTKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CH62</accession>
    <name>A0A174CH62_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavodoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_01923</name>
        <name evidence="7" type="ORF">GT712_02715</name>
        <name evidence="6" type="ORF">GT728_10720</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">BIOML-A1</strain>
            <strain evidence="7 9">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Low-potential electron donor to a number of redox enzymes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the flavodoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000023">
        <property type="protein sequence ID" value="MZL33658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS88025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381341.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12652">
        <property type="protein sequence ID" value="CUO12652"/>
        <property type="gene ID" value="ERS852478_01923"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010087">
        <property type="entry name" value="Flav_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01753">
        <property type="entry name" value="flav_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO12652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL33658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS88025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="140" mass="14893" checksum="F3748C3F67A19F6F" modified="2016-09-07" version="1">MSKVAVVYWSSTGNTEAMANAVADGIREKGGEAVLHTCEDFDGSKVAEYDAIAFGCPAMGDEVLEDTEFEPMFDGCKGALKGKNIALFGSYGWGDGEWMRNWEESCKEAGANLVCDSVICQEEPDDEATDACKALGAALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CMJ2</accession>
    <name>A0A174CMJ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5 7">regulatory protein SoxS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">soxS_2</name>
        <name evidence="7" type="synonym">soxS</name>
        <name evidence="7" type="ORF">BWLFYP14_02192</name>
        <name evidence="5" type="ORF">ERS852478_01941</name>
        <name evidence="6" type="ORF">GT728_10645</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000023">
        <property type="protein sequence ID" value="MZL33643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060005.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13140">
        <property type="protein sequence ID" value="CUO13140"/>
        <property type="gene ID" value="ERS852478_01941"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="161"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO13140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL33643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX65827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="266" mass="30457" checksum="133E99F349CBC9FA" modified="2016-09-07" version="1">MQLKYVDTKEEIIAINRKSKHIEPHLHNALEIVCVTSGALEFGVGQELYHMEKGDIGFVFPDVIHHYQVLTPGVNKATYLIASPFTIAKFADIMQSMAPEYPIIKEEKVEPEVYRVINAILETEQSDITVAQAYLQIVLARCIGKLNLVEKSNVGSNDLIYQTVSYISANFKKKFSLEEMAKDLGVSKYVLSRLFSKTFHRNFNQYLNDARLNYACHRLENTSDSITNICLDSGFESQRTFNRVFKERYKISPSDYRSTCLKDMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CPS7</accession>
    <name>A0A174CPS7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200473.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15332">
        <property type="protein sequence ID" value="CUO15332"/>
        <property type="gene ID" value="ERS852478_01987"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="4"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO15332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="340" mass="39453" checksum="5C34B41DFC644E99" modified="2016-09-07" version="1">MRNKSLDAVKAIAACLVVCIHVSFPGQAGQLVKVLARCAVPFFFMVSGYFCYYQNCNASKRILSKILHIMKLFAVSVVFYFIWECFMKAWNGERVWTWIKGLVSTEHLKEFFVYNSTSPVRAHLWFLPALIYCYLLALLIEKWRMRRAAYCMAPVLLAILLWRAEFCVFFDRFYHTMEYRNFLFTGMSFFLTGQIIHEYQDKIVCKRLEQWMQWGLKAGMIFGVALSMMEYAFRGAGEIYTGNCVAVICLFLWLILYGREINFPSVLVETGRRYAFLIYLLHPAVSDLLKKCSEGLGVSNCQIYFWLRPVLVYMLTVVTVSGISAVSAYARQNILQNNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CWR5</accession>
    <name>A0A174CWR5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyguanosinetriphosphate triphosphohydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dgt</name>
        <name evidence="3" type="ORF">ERS852478_02054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dGTPase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200518.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17467">
        <property type="protein sequence ID" value="CUO17467"/>
        <property type="gene ID" value="ERS852478_02054"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016793">
        <property type="term" value="F:triphosphoric monoester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01212">
        <property type="entry name" value="dGTPase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023023">
        <property type="entry name" value="dNTPase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="75"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO17467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="335" mass="38924" checksum="753E78FB999D7DDB" modified="2016-09-07" version="1">MNIRESMEQREQKMLSPYAALSLCSRGRERQEEECDVRTVYQRDRDRILHSKAFRRMKDKTQVFVAPQGDHYRTRLTHTLEVSQIARTIAKALRLNEDLVEAIALGHDLGHTPFGHAGERALDAVNPDGFAHYKQSVRVAQVLEKNGEGLNLTWEVRDGILNHRTSGNPSTLEGQVVRLSDKIAYIHHDMDDAQRAGIISEDDIPVTLRMLLGYTTRERLNTFVHDVIENSLEQDTIKMSAEIYEAMMDLRALMFQNVYENPAAHKEEEKVVKMLTELYEYYVEYPEAMSTEYRELIVRGEKKEQAVCDYLSGMTDQYSIRKFREIYIPKAWEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CXT1</accession>
    <name>A0A174CXT1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
                <ecNumber evidence="11">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">ribF</name>
        <name evidence="13" type="ORF">ERS852478_02019</name>
        <name evidence="14" type="ORF">ERS852523_00062</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">2789STDY5834863</strain>
            <strain evidence="14 16">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO95785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577184.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000059.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2228"/>
    <dbReference type="EnsemblBacteria" id="CUO16386">
        <property type="protein sequence ID" value="CUO16386"/>
        <property type="gene ID" value="ERS852478_02019"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95785">
        <property type="protein sequence ID" value="CUO95785"/>
        <property type="gene ID" value="ERS852523_00062"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="171"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO16386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO95785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="298" mass="34210" checksum="C944B73FCB47F359" modified="2016-09-07" version="1">MEYLRIENDFPRISHSAVTLGKFDGIHRGHQKLVEKIIEQKQEGAQAVVLALGTASRTILTKEERCRILEEMGVDILLECPLTEKIRHMKAENFIKEILIGDLQVSYVAVGEDFRFGYERKGTPAMLKEFGKKYGFHTEVLPKEMDGRRKISSTFVREELNRGNMEKFRFLMGTDFSVEGIVEHGRGMGHKYLLPTTNLIPPVEKLMPPNGVYITVSHFRDRSYQGITNVGHKPTVGGEKFIGVETYLFDCNEDLYGEYCKVDFKKFLRPEQKFSSLEALKAQLERDAVKGQEYFETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DAP3</accession>
    <name>A0A174DAP3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YcxB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200581.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21105">
        <property type="protein sequence ID" value="CUO21105"/>
        <property type="gene ID" value="ERS852478_02150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025588">
        <property type="entry name" value="YcxB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14317">
        <property type="entry name" value="YcxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="YcxB" evidence="2">
        <location>
            <begin position="106"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO21105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="175" mass="20004" checksum="67DCC8D3D1389F2A" modified="2016-09-07" version="1">MVRYSIEIGQQEQDILKEIVLASDKNVKKRKFATGLSSVMAVIMLIYTILCFMNSRIGYGIIGLLFSVFFIWIIINGANTFQKKVINIVHSKMDNKLTSGKREYCFDTDGVAVSSDIGNGTNHWNAFKCWGIFRNYIYIRTIKNEMVLVNQSDLSENDVKELKSLLSQNLKEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DEB5</accession>
    <name>A0A174DEB5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CbbX protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22410">
        <property type="protein sequence ID" value="CUO22410"/>
        <property type="gene ID" value="ERS852478_02192"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO22410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="787" mass="89664" checksum="217B40D6C92D486A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DPV7</accession>
    <name>A0A174DPV7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-ribose-binding periplasmic protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rbsB_3</name>
        <name evidence="3" type="synonym">rbsB_2</name>
        <name evidence="2" type="ORF">ERS852478_02302</name>
        <name evidence="3" type="ORF">ERS852523_01639</name>
        <name evidence="5" type="ORF">GT712_12850</name>
        <name evidence="4" type="ORF">GT728_12185</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A1</strain>
            <strain evidence="5 8">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP44432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000029">
        <property type="protein sequence ID" value="MZL33937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380185.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000081_gene3046"/>
    <dbReference type="EnsemblBacteria" id="CUO26309">
        <property type="protein sequence ID" value="CUO26309"/>
        <property type="gene ID" value="ERS852478_02302"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP44432">
        <property type="protein sequence ID" value="CUP44432"/>
        <property type="gene ID" value="ERS852523_01639"/>
    </dbReference>
    <dbReference type="GeneID" id="66494419"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="46"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO26309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP44432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="325" mass="36111" checksum="DD84350C6E8A7F08" modified="2016-09-07" version="1">MKSHKKEIITVAILMAAAVVIFAGILKPEATQTKKCSLIYIPKIRDNTNDFWTSVISGCKMAAEEYESDLEILAPDKEENIEEQNKLLKKAIEQKPDAILFSPSSMDASDELLKEAKEKGIRITYIDSYTKEELQDLTVATDNVNAGRMLGEYARKLIDKDSKIAIVSHVKGVSTAVEREQGFREGLGDYADNIVDIVYCNSLYEKSYELAQELMRKYPDLELIAGMNEYSAVGVGRAVSDAGAKDKIAVVGVDCSQEAINLMEMGVYKGIIVQKAFRMGYIGVEETIHMLNGDAVEKNIDSGCELVTPENMYNSDIERLIFPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DQ34</accession>
    <name>A0A174DQ34_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02336</name>
        <name evidence="2" type="ORF">ERS852523_01605</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO27327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP43531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381071.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000118.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000136_gene978"/>
    <dbReference type="EnsemblBacteria" id="CUO27327">
        <property type="protein sequence ID" value="CUO27327"/>
        <property type="gene ID" value="ERS852478_02336"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP43531">
        <property type="protein sequence ID" value="CUP43531"/>
        <property type="gene ID" value="ERS852523_01605"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8PZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043740">
        <property type="entry name" value="DUF5685"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18937">
        <property type="entry name" value="DUF5685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO27327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP43531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="281" mass="33337" checksum="B1A90FD8BDF64E79" modified="2016-09-07" version="1">MFGYIVMNKPEIKFKDFDLYRSFYCGLCRELKSKYGISGQISLTYDMTFVVILLSALHEPHTQKGSTRCIIHPVCKQPVRRNTVTEYAADMNVLLTYYKCRDDWEDEKKVTALGYSKVLQGKVKKLDQKYPDKSRRIQKFLSELSEMEKSGEKDIDKMAGCFGKIMEEIFAWKQDVWEDTLRRMGFFLGKFIYLLDAYDDVEEDIKNKNYNPFSEQYIIEGFDEQVRRILIMMMAQTCREFEKLPIIKYTDILRNILYSGVWCRFEVIHKKRKEAGEKDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DWN3</accession>
    <name>A0A174DWN3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="7">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ftsH_1</name>
        <name evidence="7" type="synonym">ftsH</name>
        <name evidence="13" type="synonym">ftsH4</name>
        <name evidence="12" type="synonym">hflB</name>
        <name evidence="13" type="ORF">BWLFYP14_00140</name>
        <name evidence="11" type="ORF">ERS852478_02396</name>
        <name evidence="12" type="ORF">GT712_04505</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381485.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29864">
        <property type="protein sequence ID" value="CUO29864"/>
        <property type="gene ID" value="ERS852478_02396"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
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                <person name="Groussin M."/>
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                <person name="Avila-Pacheco J."/>
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                <person name="Kearney S.M."/>
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                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
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                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
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                <person name="Vlamakis H."/>
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                <person name="Scott J."/>
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                <person name="Raman A."/>
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                <person name="Gehrig J."/>
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        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO36899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS88901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX64612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="243" mass="26693" checksum="29F85DAFD1804A5A" modified="2016-09-07" version="1">MSGHSKFANIKHKKEKNDAKKGKIFTVIGRELVMAVKAGGPDPNNNSKLRDVIAKAKANNMPNDTIERGIKKAAGADSADNYEKAVYEGYGPNGVAIIVETLTDNKNRTAGNVRNAFTKGNGSIGTQGCVSYMFDQKGQIIIDKEECEMDADEIMMLALDAGAEDFSEEEDSYEILTAPDDFSAVREALEKAGLPIAEAQVAMIPQTYVELTDEQALKDLQRTLDLLDDDDDVTDYWTNWDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EP61</accession>
    <name>A0A174EP61_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Toxin A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">toxA_3</name>
        <name evidence="4" type="ORF">ERS852478_02676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO39261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39261">
        <property type="protein sequence ID" value="CUO39261"/>
        <property type="gene ID" value="ERS852478_02676"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018337">
        <property type="entry name" value="Cell_wall/Cho-bd_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01473">
        <property type="entry name" value="Choline_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19127">
        <property type="entry name" value="Choline_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51170">
        <property type="entry name" value="CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020926" evidence="3">
        <location>
            <begin position="24"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="Cell wall-binding" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO39261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="323" mass="36771" checksum="68C7677AF07AA029" modified="2016-09-07" version="1">MKKMTKWLAVCAVCVMGSVPAMAAEVPDVTVTPIPIETPAPDVTPIETPAPTPIPEVKNGWYEYGTKNKKYFKDGQYLTGMRKIYGEVYYFSPKGFMKTGWIKYNNKKYYFGSNGIRYSGVKKISGKYYYFSDKGVLRTKTVKVGNTIYYCTEKGILEAWKKGKTIYYPNGKKMNSTKAYEYETLQRAKDVVSKITKPSMSKSEKFETCFRWVMYQHYYDTRRIFYNQTAWPALYANDYLILSGKGGDCFSDACSFAYLAKALGYKNVYVCVDTTATDGSGHCWAEIGGRVYDPLFAEAKSYYGYFGVGYGSYGLYPERRVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EWU2</accession>
    <name>A0A174EWU2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable diguanylate cyclase YeaP</fullName>
            <ecNumber evidence="5">2.7.7.65</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yeaP</name>
        <name evidence="5" type="ORF">ERS852478_02766</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.65" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200910.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42433">
        <property type="protein sequence ID" value="CUO42433"/>
        <property type="gene ID" value="ERS852478_02766"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021122" evidence="3">
        <location>
            <begin position="28"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="580"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO42433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="748" mass="85741" checksum="CC9B722FB78AB388" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EY98</accession>
    <name>A0A174EY98_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200892.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41628">
        <property type="protein sequence ID" value="CUO41628"/>
        <property type="gene ID" value="ERS852478_02751"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
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        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="112"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO41628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="264" mass="28678" checksum="1420330210F62B8C" modified="2016-09-07" version="1">MKKQPKNKVLFLIPVGVILAGAVIFLCTRGNENDSVCKENVARLQALENSDISQTEEQLQALKQTTGISSGSDASDSSGSTLLSDVEIRQVFAGNVIIGDSITESIVEYGYLDTDVVVSKRGLNVGAADDQISTAIALNPSHVFMAFGSNDLEIYGSASSEFIDAYRTQIKKIQTALPDVPIYINCILPITDEAIAQTPDLGYYPDYNEGLIKLCQEMGCTFIDNSTIVTDSSENLYEPDGEHVIQDYYPKWLTNMAQIAGLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F0A5</accession>
    <name>A0A174F0A5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yheH</name>
        <name evidence="10" type="ORF">ERS852478_02786</name>
        <name evidence="11" type="ORF">GT728_15840</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000046">
        <property type="protein sequence ID" value="MZL34626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_WWVQ01000046.1"/>
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        <property type="protein sequence ID" value="CUO42987"/>
        <property type="gene ID" value="ERS852478_02786"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ABC-type transporter activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
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        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="31"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="388"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="421"/>
            <end position="428"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO42987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL34626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="627" mass="69885" checksum="D1EF1DA9D1C8C4F0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F362</accession>
    <name>A0A174F362_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfite reductase, dissimilatory-type subunit beta</fullName>
            <ecNumber evidence="8">1.8.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dsvB</name>
        <name evidence="8" type="ORF">ERS852478_02773</name>
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    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42615">
        <property type="protein sequence ID" value="CUO42615"/>
        <property type="gene ID" value="ERS852478_02773"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
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            <end position="216"/>
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    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO42615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="289" mass="31786" checksum="0E3117246F98B658" modified="2016-09-07" version="1">MAQKVDYAALKKGGYMRQKQKGYGSLRLAVVGGNLTAENIKTVAEVAEKYGRGYVHMTSRQGIEIPFIKVEELAEVKEALAKGGVGTGVCGPRVRTVTACQGSEVCPSGCIDTYTLAKELDERYFGRELPHKFKFGVTGCQNNCLKAEENDVGIKGGMNIEYKEDDCISCGVCVKACRQNALKMVDGKIELDAQKCNHCGRCVKSCPVDAWKGTPGYIVSFGGTFGNNIYKGEELLPLIPDKETLFRVTDAAINFFEKNANPSERFRKTLQRVGEEDFRSQLKDAYEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F443</accession>
    <name>A0A174F443_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380561.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45013">
        <property type="protein sequence ID" value="CUO45013"/>
        <property type="gene ID" value="ERS852478_02853"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="25"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO45013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="366" mass="42186" checksum="18633B4A103102C5" modified="2016-09-07" version="1">MEINREIKNITSAFVLEDNLTECIPYGSGHINDTYRLTYDTGKHYILQKMNKSIFTKPIELMENVSGVTAWLKKKIQENGGDVDRETLNLVMTKDGLPYYVDEDGEYWRVYLFIEDATCYDMVKDEEDFYQSAVAFGHFQRLLADYPAETLHETIVNFHNTVDRLDKFKTAVEKDICHRAADVEKEIQFVLDRTELAHVLCDMQDQGKLPLRVTHNDTKLNNIMIDNATGKAICVIDLDTVMPGLSVNDFGDSIRFGASTGAEDEKDLTKVSCDLHLYEVYVKGFIEGCGGALTETELDMLPMGAILMTFECGMRFLTDYLEGDHYFKIHREGHNLDRCRTQFKLVKDMEEKLSRMKEIVNKYKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F8G9</accession>
    <name>A0A174F8G9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltose-binding periplasmic proteins/domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45136">
        <property type="protein sequence ID" value="CUO45136"/>
        <property type="gene ID" value="ERS852478_02859"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021453" evidence="1">
        <location>
            <begin position="28"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO45136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="422" mass="47604" checksum="9C87B6BA4171FE02" modified="2016-09-07" version="1">MEKWRSIAAGMSCLSMLFATGAVTVSASDEITEIPEQSIVYWSMWEEDEPQADVIREAAEAYEEATGISVEIQWKGRGIRSLIEPALDAGEQIDLFDDDYQRMAQEHRDYLAELKGMADTVDYEKHIMPVLLEQVKNWGNGELLAMPYQPYITGVWYNKDLWEEAGLTEQDIPDTWEKLIRVCRKIKNSDSGLSAMTCDEEYVNLLYGYQLVRYLGQEKVQQLIRNCTWSQIPQAKEAADDIRILFFAGYMSQSAPAQHPEGQDEVGDGEAVMVLQGSWVPNEVTEATESDDSWGFFPWPAVKAGTDGTEGVMVGAQGFGVTKDSQMKQEAFDFAYSICTGETDMKMTDAVNSIPADTDNTQWPEVLADAVPYMKEMSKPYMWAAGLEANPDYKEQIQSELLKLTRLEETSDEFIENLSNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FA91</accession>
    <name>A0A174FA91_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable sensor-like histidine kinase YehU</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yehU_7</name>
        <name evidence="5" type="ORF">ERS852478_02874</name>
        <name evidence="6" type="ORF">GT728_17220</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000057">
        <property type="protein sequence ID" value="MZL34882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379823.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45579">
        <property type="protein sequence ID" value="CUO45579"/>
        <property type="gene ID" value="ERS852478_02874"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="504"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO45579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL34882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="608" mass="71043" checksum="E3F121A248EE4F30" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FC07</accession>
    <name>A0A174FC07_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">tuf</name>
        <name evidence="12" type="ORF">BWLFYP14_03392</name>
        <name evidence="10" type="ORF">ERS852478_02923</name>
        <name evidence="11" type="ORF">GT712_01155</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705156.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47097">
        <property type="protein sequence ID" value="CUO47097"/>
        <property type="gene ID" value="ERS852478_02923"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="82"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO47097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS87732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX67115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="397" mass="43774" checksum="8C9AC1DBA84A36B2" modified="2016-09-07" version="1">MAKAKFERTKPHCNIGTIGHVDHGKTTLTAAITKVLAERVAGNVVENFEDIDKAPEERERGITISTAHVEYQTEKRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGVMAQTKEHVLLARQVGVPYIVVFMNKCDMVDDEELLELVEMEIRELLSEYDFPGDDIPVIKGSALKALEDPNGEWGDKIMELMDAVDSYIPDPQRDTDKPFVMPVEDVFSITGRGTVATGRVEAGVLHVSDEVEIVGIKEETRKVVVTGIEMFRKLLDEAQAGDNIGALLRGVQRNEIERGQVLAKPGTLTCHTKFTAQVYVLTKDEGGRHTPFFNNYRPQFYFRTTDVTGVCNLPEGTEMCMPGDNIEMTIELIHPIAMSQGLTFAIREGGRTVGSGRVATIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FEF3</accession>
    <name>A0A174FEF3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cobalt-precorrin-2 C(20)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.151</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Precorrin-2 C(20)-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.130</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cbiL</name>
        <name evidence="11" type="synonym">cobI</name>
        <name evidence="13" type="ORF">BWLFYP14_03605</name>
        <name evidence="9" type="ORF">ERS852478_02945</name>
        <name evidence="10" type="ORF">ERS852523_01506</name>
        <name evidence="12" type="ORF">GT712_01900</name>
        <name evidence="11" type="ORF">GT728_07265</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.151" evidence="9"/>
    <dbReference type="EC" id="2.1.1.130" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO47947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP40282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000013">
        <property type="protein sequence ID" value="MZL33004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706308.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000028_gene218"/>
    <dbReference type="EnsemblBacteria" id="CUO47947">
        <property type="protein sequence ID" value="CUO47947"/>
        <property type="gene ID" value="ERS852478_02945"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP40282">
        <property type="protein sequence ID" value="CUP40282"/>
        <property type="gene ID" value="ERS852523_01506"/>
    </dbReference>
    <dbReference type="GeneID" id="66493646"/>
    <dbReference type="eggNOG" id="COG2243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043781">
        <property type="term" value="F:cobalt-factor II C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036427">
        <property type="entry name" value="Precrrn-2_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO47947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP40282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL33004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS87877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX67330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="231" mass="25441" checksum="91B7481AB0FBA54D" modified="2016-09-07" version="1">MRGILYGVGVGPGDPELMTLKAVRLIKENDIIAVPGAEVRETVAYKIAVQAVPELADKELLPIYMPMTHDKAELELNHEKGAKALEAALDTGKNVVFLTLGDPTIYSTFSYVQKRVEADGYETRLVSGITSFCATAARLNIPLTEWNQPLHVQPAVHRLDSELDQPGTYVLMKSGKKMNQVKEILAKSGRNIRMVENCGMPDEHIYNSVEEIPDDAGYYSLIIAKEQDGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FWH4</accession>
    <name>A0A174FWH4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sphR_2</name>
        <name evidence="10" type="synonym">sphR_1</name>
        <name evidence="10" type="ORF">BWLFYP14_00679</name>
        <name evidence="9" type="ORF">ERS852478_03142</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO54584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000015">
        <property type="protein sequence ID" value="VUX62930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201196.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54584">
        <property type="protein sequence ID" value="CUO54584"/>
        <property type="gene ID" value="ERS852478_03142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="127"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO54584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX62930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="230" mass="26067" checksum="528B487F17EF8096" modified="2016-09-07" version="1">MKQILIVEDDSFLNKMLDYNLTADGYGVTSALNARTAADAIRQREFDLVLLDINLPDGNGFELCKLIKPQHPDTIVIFLTANDQESDQIRGYEAGAVDYITKPFVIGALQRKIKAMFAMLEHHKPAKDIFDDGRLFLDFSEQTASLNGKPLTLSPMEYKMLNLFRKNPRQVLTRGQLLEKLWDIDERFVDEHTLTTSISRIRSKIESDGGAPYIKTVYGMGYQWTGGEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G4I7</accession>
    <name>A0A174G4I7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA ATPase containing von Willebrand factor type A (VWA) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201240.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57462">
        <property type="protein sequence ID" value="CUO57462"/>
        <property type="gene ID" value="ERS852478_03223"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="62"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO57462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="306" mass="34599" checksum="FD543C6BC04C31A1" modified="2016-09-07" version="1">MEELKFLEEQQVAPELIKRVEEFRSRYEVVPETADRIVKPSIPFYGKDILEMAIAGLLKGENLLLTGPKATGKNILAENLAYIFNRPAYNVSFHVNTNSGDLIGTDTFVDNEVKLRKGTIYQCAEYGGFGILDEINMAKNDAVSVLHATLDYRRSIDVPGYDKIDLHPAARFIGTMNYGYAGTKELNEALVSRFLVIDMPAQTEESLEFIFRRMFPNIKENARTQFIGVFLDLQLKATNSEISTKPLDLRGLLAAMKIVETGLSPRKAVTMGVVNKTFDIFEKEIVEDIVKTRIPADWTRDDVYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G5Y1</accession>
    <name>A0A174G5Y1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Coenzyme PQQ synthesis protein D (PqqD)</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">PqqD family peptide modification chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_00317</name>
        <name evidence="1" type="ORF">ERS852478_03220</name>
        <name evidence="3" type="ORF">GT712_16750</name>
        <name evidence="2" type="ORF">GT728_05025</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">BIOML-A1</strain>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000045">
        <property type="protein sequence ID" value="MZS90662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707355.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57381">
        <property type="protein sequence ID" value="CUO57381"/>
        <property type="gene ID" value="ERS852478_03220"/>
    </dbReference>
    <dbReference type="GeneID" id="66496189"/>
    <dbReference type="eggNOG" id="ENOG50330XY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO57381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL32581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX67472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="121" mass="14327" checksum="7AF93C60ABDA13EE" modified="2016-09-07" version="1">MSKKKKELQINYLDLIPERSAQLRWHTDIRGRMVLEIENKGAFNTIAQKLFGKPRYTKIHLDDNGTFIWPLIDGRKTVEDIAALVKDEFGEKAEPLYPRIVKYFQIMESYHFVNFINKPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G8T9</accession>
    <name>A0A174G8T9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein conserved in bacteria (DUF2179)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852478_03271</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO58854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381004.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58854">
        <property type="protein sequence ID" value="CUO58854"/>
        <property type="gene ID" value="ERS852478_03271"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="227"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO58854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="284" mass="31504" checksum="300176F832BE791B" modified="2016-09-07" version="1">MKKQLNYADIIKEALILTGAVAIIAAAVYFFLVPSHTSVSSISGLGIVLSNFVPLSLSAITMILNVVLLIIGFITCGREFGVKTVYTSIVLPLFLGLFEKVFPDFGSMTNSQELDVLCYILVVSVGLSILFNRNASSGGLDIVAKIMNKHLHMELGKAMSLSGMCVALSAALVYDKKTVVLSILGTYFNGIVLDHFIFDHNIKRRVCVITQKEEELRKFIIKDLHSGATIYEATGAYNMKKRNEIITIVDKTEYQKLMAYINHEDPKAFVTVYNVSDMRYQPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GCA3</accession>
    <name>A0A174GCA3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein MgsR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Regulatory protein spx</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spxA</name>
        <name evidence="4" type="synonym">mgsR</name>
        <name evidence="4" type="ORF">BWLFYP14_03511</name>
        <name evidence="2" type="ORF">ERS852478_03295</name>
        <name evidence="3" type="ORF">ERS852523_04100</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO59531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000080">
        <property type="protein sequence ID" value="CUQ13520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705078.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000010_gene2773"/>
    <dbReference type="EnsemblBacteria" id="CUO59531">
        <property type="protein sequence ID" value="CUO59531"/>
        <property type="gene ID" value="ERS852478_03295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ13520">
        <property type="protein sequence ID" value="CUQ13520"/>
        <property type="gene ID" value="ERS852523_04100"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006504">
        <property type="entry name" value="Tscrpt_reg_Spx/MgsR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01617">
        <property type="entry name" value="arsC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO59531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ13520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX67236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="117" mass="13816" checksum="B4E212C7DA2DD2D4" modified="2016-09-07" version="1">MKVLVYRKCSTCMKALKWLDEHNINYEERAIKEENPTYEELKKWYAKSGLPLKKFFNTGGMIYKEMGLKDKLKDMSEDEQLKLLATDGMLVKRPLVIGDDFVLTGFREKEWSEAMHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GGA3</accession>
    <name>A0A174GGA3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator immR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">immR_7</name>
        <name evidence="2" type="ORF">ERS852478_03303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO59980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201273.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59980">
        <property type="protein sequence ID" value="CUO59980"/>
        <property type="gene ID" value="ERS852478_03303"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO59980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="109" mass="12566" checksum="C016222BFCEB388F" modified="2016-09-07" version="1">MGNRIKIRRKELRIKQAELAERLNISNSHMSSIENGRQKPSLDIFIQICNLLNVTPDYLLLGSMHAYNIPQDIIDKLRLCNQSDIELAGDFIELLVKRNNKATHNEPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GKY5</accession>
    <name>A0A174GKY5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative UDP-N-acetyl-D-mannosaminuronic acid transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO62661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62661">
        <property type="protein sequence ID" value="CUO62661"/>
        <property type="gene ID" value="ERS852478_03379"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO62661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="177" mass="20190" checksum="EAC63B35F04846F9" modified="2016-09-07" version="1">MEYKRKVDKKCIPTCNIMGVNIAAINMEWLVDYLEKNISEIKGDYVCVSNVHTTVTSFEDADYCAIQNGGLMAIPDGGPLSTVGQKRGHKNMERTTGPSLMGEIFEISAKKGYRHYFYGSKEETLELLQKKLMEKYPEIQIAGMYSPPFRPLTEEEDKVIIERINETKLLRKQSELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GN94</accession>
    <name>A0A174GN94_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61915">
        <property type="protein sequence ID" value="CUO61915"/>
        <property type="gene ID" value="ERS852478_03361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO61915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="61" mass="7037" checksum="183FCFB7CF5A6D5A" modified="2016-09-07" version="1">MNREEKARQEDVYKCSLHGLYISVIYQHTYGTPQSVAGTAVSLDESIIYNRILQQNIYKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GTS2</accession>
    <name>A0A174GTS2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin reductase</fullName>
            <ecNumber evidence="4">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trxB_3</name>
        <name evidence="8" type="ORF">BWLFYP14_02359</name>
        <name evidence="7" type="ORF">ERS852478_03489</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201414.1">
        <property type="nucleotide sequence ID" value="NZ_WWVG01000122.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65913">
        <property type="protein sequence ID" value="CUO65913"/>
        <property type="gene ID" value="ERS852478_03489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="6">
        <location>
            <begin position="7"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO65913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX65989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="318" mass="34740" checksum="F6A369B9AEBD2183" modified="2016-09-07" version="1">MNENHVYDMIIVGGGPGGYTSALYAARAGFDTIVLEKLSAGGQMSLTWQIDNYPGFENGIDGFSLAEKMQKQAEKFGAKSEYAEVFNMNLTGKLKRVETSSGIYIGKTVVIATGANPRELGLAKEKELIGHGVAYCASCDGMFYKDKIVVVVGGGNSAVSDAVLLSRIAKKVIIVHRRDTLRATKIYHDQLLKTENIEFRWNNTVNELIYGERLTGVRLKDTVTGEENIIECDGLFVSIGRKPTTDFLDNQIELDNKGYIVAGENTETSIPGVYAVGDVRTKLLRQIVTAVADGAMAVHMAEKYMDLTVAMSKPYLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H432</accession>
    <name>A0A174H432_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69001">
        <property type="protein sequence ID" value="CUO69001"/>
        <property type="gene ID" value="ERS852478_03586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO69001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="37" mass="4314" checksum="174F7FDC5AF59F49" modified="2016-09-07" version="1">MDFTILAVVLLIGVGVPIRNKLIRKYRDKKKNDRNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H5N7</accession>
    <name>A0A174H5N7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type III restriction enzyme, res subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_03567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201441.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68299">
        <property type="protein sequence ID" value="CUO68299"/>
        <property type="gene ID" value="ERS852478_03567"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T5orf172" evidence="3">
        <location>
            <begin position="25"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="126"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO68299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1107" mass="126938" checksum="DEDFC032E9049C8E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H676</accession>
    <name>A0A174H676_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">YheO-like PAS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_00090</name>
        <name evidence="2" type="ORF">ERS852478_03635</name>
        <name evidence="3" type="ORF">ERS852523_03284</name>
        <name evidence="5" type="ORF">GT712_04130</name>
        <name evidence="4" type="ORF">GT728_01775</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000044">
        <property type="protein sequence ID" value="CUP92268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL31962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993722.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1173"/>
    <dbReference type="EnsemblBacteria" id="CUO70492">
        <property type="protein sequence ID" value="CUO70492"/>
        <property type="gene ID" value="ERS852478_03635"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP92268">
        <property type="protein sequence ID" value="CUP92268"/>
        <property type="gene ID" value="ERS852523_03284"/>
    </dbReference>
    <dbReference type="GeneID" id="66494332"/>
    <dbReference type="eggNOG" id="COG2964">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039446">
        <property type="entry name" value="DauR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039445">
        <property type="entry name" value="DauR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013559">
        <property type="entry name" value="YheO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35568">
        <property type="entry name" value="PTHR35568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13309">
        <property type="entry name" value="HTH_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08348">
        <property type="entry name" value="PAS_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="1">
        <location>
            <begin position="73"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO70492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP92268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL31962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="210" mass="23222" checksum="C096CC72ECFA73FD" modified="2016-09-07" version="1">MGRLTVLKQIAADLASQFGPDCEVVIHDLKTSEPEHSIVYIVNGHVTNRDIGDGPSNAVFDAIRNQEKGATPEDHTGYLMKTADGKILKCSTSYIHDDDGTLHYVFGINYDITKLTMIESALHSLVTPENKEEKPKEITHNVNDLLDHLIEESVALVGKPVPLMNKEDKVTAIQFLNDAGAFLITKSGDKVANYFGISKYTLYSYIDVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H8K9</accession>
    <name>A0A174H8K9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69538">
        <property type="protein sequence ID" value="CUO69538"/>
        <property type="gene ID" value="ERS852478_03608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO69538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="248" mass="28599" checksum="4D13BD771EBEB016" modified="2016-09-07" version="1">MKLEERKQNSFIQKSIFLLIIMTLWICLGTGFTVNAAQREDTKLLKIYDGKSIEASQIQFKAEVATPDSNRIDIYRSEKPVSQGGKLEKLDSFRVIGDFWEVLGDNLYMNYGDNFKVQCYSHDTCVEGNLTFVDTTAKAGHQYSYRLVYGDMVYDPDSGEYSVEIVSNIIDVKANLQTPELYKCYSTDNKTVNLSWSYIAQADGYRVYRYDNGKWSFLKNVKKRNVITTTDKNVQAGKTYQYRVLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HF23</accession>
    <name>A0A174HF23_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rod shape-determining protein RodA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_03740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000046">
        <property type="protein sequence ID" value="CUO73483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379876.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000071.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73483">
        <property type="protein sequence ID" value="CUO73483"/>
        <property type="gene ID" value="ERS852478_03740"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO73483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="510" mass="57119" checksum="7A7FC6035D9C78B6" modified="2016-09-07" version="1">MDEYLKTLLEQIRCKKARPYVKQEFQDHIEDQIEANMQAGMDREQAEREAVRDMGDPVETGISLDSVHRPQVAWKLLGIIVLISIAGVLIHAGIAGKISENAAAGSDRYVFHVVIGLAVMMILYLLDYTVLARFSKIIAVILLFACLVTLLGGYQLNGARYFIVLPGGRGISMQTLMLFYVPIYGAILYKYHGWGYKGLMRAIIWMIAPVILVYAMPALMPACMMLVSMLVMLTIAIQKNWFTVRKKKAICGIWAGFLAMPVAAFLIRYLSSSLTEYQIARLQAIFSDGGEEDYFTGMLHSFWQQNKWIGKSESDVMGNLPAFNADYILTYLSSVYGTIAAVLLCCVLAVLIFAVFNTSMRQKNQLGMMMGCGCGIVFLVNFSINILENLGVFPQSVTFLPFLSAGGSCIIVSYGLMGIVLSTYRYKNIYPRHLKIGFKFDKTKARKALYVSKMSMCILTGGTVAVMCIAIYWDLCKAYMNIPFKIIAIVLILLLVGNMRRIVQYNEMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HGW2</accession>
    <name>A0A174HGW2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arabinose operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">araC_4</name>
        <name evidence="5" type="ORF">ERS852478_03711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000044">
        <property type="protein sequence ID" value="CUO72606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201501.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72606">
        <property type="protein sequence ID" value="CUO72606"/>
        <property type="gene ID" value="ERS852478_03711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="190"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO72606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="291" mass="34256" checksum="A23CE53533F64644" modified="2016-09-07" version="1">MKDLFVNTQLPVVTSDRILYTPSNFARTSLLYLQEIGSLQVHKPHSTGRSNLSSYLFFTVTDGEGELICEGRTYSLRTGDCVFIDCRKQYAHSSSEKLWSLSWIHFYGPNMTAIYDKYLERGGRAVFHPVSVSGFLEICHRIYELADSDDYIRDMKINSELNYLLTLLMNESWHPGEKHRDADLKKQNVLPVKQYLDEHYQEKISLDFLAEHFFISKYYLTRVFREQLGVSISSYLMNRRVTKAKYMLRFSDEKIKTIGYKCGLGEPHYFSRVFRQMEGMSPLEYREKWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HK19</accession>
    <name>A0A174HK19_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03739</name>
        <name evidence="3" type="ORF">GT712_18725</name>
        <name evidence="2" type="ORF">GT728_19095</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 5 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A1</strain>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000046">
        <property type="protein sequence ID" value="CUO73460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000080">
        <property type="protein sequence ID" value="MZL35221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000063">
        <property type="protein sequence ID" value="MZS91016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059820.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73460">
        <property type="protein sequence ID" value="CUO73460"/>
        <property type="gene ID" value="ERS852478_03739"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO73460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL35221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS91016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="275" mass="31718" checksum="772A45EFEB15F63B" modified="2016-09-07" version="1">MANAKHEDAVMKMGFDYFRNTILKTLGIDYQYEEIGPTELVELTIQSLYMDFTFLTTGGFYIHTEFQTTDKKEADLRRFHAYDAVYSNKTGKKVITYVIYSGGITNVKSELDCGLYTYRVQPIYLKDKNADEVFRKLKQKQDNGDVFTEDDYAALSLTPLMSGKMSRKDMFKEAICLAKPNIELSAEKATAMLYTLADKFLDRAELDEIKEVMRMTRLGQMLMDEGMEKGIELKETDSIKKLMKNMNLTIDQAMNALEVPTDKREKYRKTITPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HKZ8</accession>
    <name>A0A174HKZ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydro-3-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">eda_2</name>
        <name evidence="2" type="ORF">ERS852478_03809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000052">
        <property type="protein sequence ID" value="CUO75602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75602">
        <property type="protein sequence ID" value="CUO75602"/>
        <property type="gene ID" value="ERS852478_03809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO75602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="207" mass="22419" checksum="2E7537CC019462AC" modified="2016-09-07" version="1">MDMYSVVKENPILAILRNIPLEYTVDYAQAIVDGGISFFEVALNSEHGLKQIAILRDRFGEKCMIGAGTAISVDLAKAAIGAGAQFLLTPGTPIDVLQYCAKKDIMLLPGVFTPGDVATSLEFGYKTMKLFPAGCAPKGYLKALKGPYDEANYIAIGGVTIDNINDYFKEGYMGVGLASNLMPLSVLKDKNWDLGVSYVQKYVSRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HMR4</accession>
    <name>A0A174HMR4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_03773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000048">
        <property type="protein sequence ID" value="CUO74380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704442.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74380">
        <property type="protein sequence ID" value="CUO74380"/>
        <property type="gene ID" value="ERS852478_03773"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="338"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO74380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="473" mass="53277" checksum="0516C152635C7976" modified="2016-09-07" version="1">MIGVIRKFKTASPAVKASMALLFANLILKGISLISGPIFTRIMSADQYGIVSTFQSWQSLLTVIVTLNLSQGVFNNGMLEFKENRNQFQFALVVITAVCTGLFFLIFEIFKTPLLNMFEIPPVMVYVMVLYFLFVPAYQFWSGRQRYEYKYKALSIITVCIGLFSLLLGVLFVLNASSENEAIARVCAMEGVNIVVGIFFFMIIAMKAQFKLRIDYCIYALKFNIPLIPHYMSMYILASSDRIMITKMIDTTSTAIYSVAYTVASVIQILWTSIEASLSPWIYERLDVQDEESVRKTSGQIMLTFAVFCLGCTLFAPEIMTILAPDSYKAGIYAIPAIAGGVYFTAVYSLYMRIELFYKKTTFATVASTIAAVSNIILNYIFIKLFGFVAAGYTTMVCYALLALLHYINVKNKKYDDAIDNKKILAISIVVIVVSILISILYSHRLLRYSFILIISLAAFIKRKAIIVMLRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HPQ1</accession>
    <name>A0A174HPQ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF4317 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03793</name>
        <name evidence="2" type="ORF">GT712_14645</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000050">
        <property type="protein sequence ID" value="CUO75060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000033">
        <property type="protein sequence ID" value="MZS90275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070100648.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75060">
        <property type="protein sequence ID" value="CUO75060"/>
        <property type="gene ID" value="ERS852478_03793"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9QV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025466">
        <property type="entry name" value="DUF4317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14199">
        <property type="entry name" value="DUF4317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO75060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS90275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="225" mass="25852" checksum="86710F3F4005DD84" modified="2016-09-07" version="1">MNKKDTKINRNDMLELTRRMTLSRNCFVRTAGAYIDDEGYIDNTFNVSFKNMSKHDQQVNLDLAKTIPFSKTNEQLKRYKFPEGDMAYDSIHKLLMALSQYGLKDDLLVQTLCEQLAEGICSTRDSSNGTNRLQGQEFGIYIYHGIYDIPKKGSDHSEQWESEEIYSFLICVVAPVDKDYNAGTPKCGFIFPAFEDRSAEPGKIDVFFEIPEHPDEGFLNRIIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HQP3</accession>
    <name>A0A174HQP3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolyl-tRNA deacylase proX</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Prolyl-tRNA synthetase associated domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">proX</name>
        <name evidence="3" type="ORF">ERS852478_03833</name>
        <name evidence="5" type="ORF">GT712_15320</name>
        <name evidence="4" type="ORF">GT728_21555</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A1</strain>
            <strain evidence="5 7">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRORSD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000057">
        <property type="protein sequence ID" value="CUO76521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000137">
        <property type="protein sequence ID" value="MZL35671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000037">
        <property type="protein sequence ID" value="MZS90402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704233.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000137.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76521">
        <property type="protein sequence ID" value="CUO76521"/>
        <property type="gene ID" value="ERS852478_03833"/>
    </dbReference>
    <dbReference type="GeneID" id="66494469"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040285">
        <property type="entry name" value="ProX/PRXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31423">
        <property type="entry name" value="PTHR31423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="2">
        <location>
            <begin position="45"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO76521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL35671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="183" mass="20973" checksum="8139166D47760A07" modified="2016-09-07" version="1">MELQKGRPENTDNRLDKEIRVYDFLDKLGVQYQRIDHEAAMTMEACEEIDHALGDNTTICKNLFLCNRQETDFYLLLMPGDKPFKTKDLSAQIHSARLSFAKPEYMEKYLDITPGSVSVLGLMNDSEKKVQLLIDEDVMKEPYFGCHPCINTSSLKFTTEDLMQKIIPALEHEPVTVTLPVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HRK2</accession>
    <name>A0A174HRK2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_03465</name>
        <name evidence="1" type="ORF">ERS852478_03806</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000052">
        <property type="protein sequence ID" value="CUO75529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000081">
        <property type="protein sequence ID" value="VUX67190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75529">
        <property type="protein sequence ID" value="CUO75529"/>
        <property type="gene ID" value="ERS852478_03806"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO75529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX67190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="62" mass="7377" checksum="FEE88693F37100E2" modified="2016-09-07" version="1">MLSSQLKLSLSYYSDLYDMIVPKDHILRKIRELVDFSFIYDELKNKYCLDNGRNAKNPYIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HUT2</accession>
    <name>A0A174HUT2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tnp_DDE_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000060">
        <property type="protein sequence ID" value="CUO76800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76800">
        <property type="protein sequence ID" value="CUO76800"/>
        <property type="gene ID" value="ERS852478_03836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13751">
        <property type="entry name" value="DDE_Tnp_1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="1">
        <location>
            <begin position="46"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO76800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="181" mass="21217" checksum="66082EE94681054A" modified="2016-09-07" version="1">MLKFLYILFYLAQQVKLISKLNPSIIKGTRSEEGFIFNKDADTMQCPAGHLAIKYRIDKRSNQKKNTRIKYFFDINKCHVCPYRNGCYKENAKNKTYSITIKSDYHKNQEAFQKTQYFKERFKTRYMIEAKNSELKNIHGYSRCDAAGLSNMQLQGAVSIFAVNLRRILKLKGEVCPNEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JRW8</accession>
    <name>A0A174JRW8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0102 protein BWLFYP14_02464</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02464</name>
        <name evidence="3" type="ORF">ERS852478_02596</name>
        <name evidence="4" type="ORF">ERS852523_00193</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000002">
        <property type="protein sequence ID" value="CUO99900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000050">
        <property type="protein sequence ID" value="VUX66092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000003_gene1610"/>
    <dbReference type="EnsemblBacteria" id="CUO36518">
        <property type="protein sequence ID" value="CUO36518"/>
        <property type="gene ID" value="ERS852478_02596"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99900">
        <property type="protein sequence ID" value="CUO99900"/>
        <property type="gene ID" value="ERS852523_00193"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00252">
        <property type="entry name" value="TIGR00252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO36518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO99900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="121" mass="14087" checksum="3054EB8657C9DAC6" modified="2016-09-07" version="1">MHKNTRSTGSCYERKAADYLKQQGLFILRYNYRCRFGEIDLIARDGEYLVFVEVKYRKDNSSGYSLAAVNPAKQKTICKVARYFLTVEYHNVDIPCRFDVAGIDGDEIHWVKNAFEYIAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KQ15</accession>
    <name>A0A174KQ15_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBS domain protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Predicted transcriptional regulator with C-terminal CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01777</name>
        <name evidence="3" type="ORF">ERS852478_00744</name>
        <name evidence="4" type="ORF">ERS852523_00599</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP11685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380489.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000016_gene3687"/>
    <dbReference type="EnsemblBacteria" id="CUN66569">
        <property type="protein sequence ID" value="CUN66569"/>
        <property type="gene ID" value="ERS852478_00744"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11685">
        <property type="protein sequence ID" value="CUP11685"/>
        <property type="gene ID" value="ERS852523_00599"/>
    </dbReference>
    <dbReference type="GeneID" id="66493519"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN66569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP11685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="141" mass="16177" checksum="5616716EDB42076C" modified="2016-09-07" version="1">MNILFFLTPKSDVAYIFENETLRQTLEKMEHRKFSCIPLLSLDGKYKGSISEGDLLWGMKTLNVPGLKEAESISIMAIPRRATYKAVHADSDMEDLLDKAINQNYVPVVDDQGYFIGIITRKEIIKYCYKELKKYIKASDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MG83</accession>
    <name>A0A174MG83_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anti-sigma F factor</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Stage II sporulation protein AB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">spoIIAB</name>
        <name evidence="8" type="ORF">BWLFYP14_00240</name>
        <name evidence="5" type="ORF">ERS852478_01575</name>
        <name evidence="6" type="ORF">ERS852523_01310</name>
        <name evidence="7" type="ORF">GT728_04620</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
            <strain evidence="6 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anti-sigma-factor family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP34101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994121.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000057_gene2525"/>
    <dbReference type="EnsemblBacteria" id="CUN99747">
        <property type="protein sequence ID" value="CUN99747"/>
        <property type="gene ID" value="ERS852478_01575"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP34101">
        <property type="protein sequence ID" value="CUP34101"/>
        <property type="gene ID" value="ERS852523_01310"/>
    </dbReference>
    <dbReference type="GeneID" id="66496106"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016989">
        <property type="term" value="F:sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030436">
        <property type="term" value="P:asexual sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042174">
        <property type="term" value="P:negative regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00637">
        <property type="entry name" value="Anti_sigma_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010194">
        <property type="entry name" value="Anti-sigma_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01925">
        <property type="entry name" value="spIIAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="4">
        <location>
            <begin position="37"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN99747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP34101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL32502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX67399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="141" mass="15749" checksum="025530CA63222FFF" modified="2016-09-07" version="1">MENTNEMKIIFDSRPENEGLARVAAAAFCTQLNPTLEEVADLKTAVSEAVTNCIIHAYEGQVQKIEIFCRREGQKLWVDVIDKGVGIRDVAKAMEPLFTTKPEKDRSGMGFTFMEAFMDEVTVESQVGYGTVVHMKKTIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MHH5</accession>
    <name>A0A174MHH5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="3">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Spermidine synthase</fullName>
            <shortName evidence="3">SPDS</shortName>
            <shortName evidence="3">SPDSY</shortName>
            <ecNumber evidence="3">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 9" type="primary">speE</name>
        <name evidence="12" type="ORF">BWLFYP14_02111</name>
        <name evidence="8" type="ORF">ERS852478_00511</name>
        <name evidence="9" type="ORF">ERS852523_01361</name>
        <name evidence="11" type="ORF">GT712_12450</name>
        <name evidence="10" type="ORF">GT728_11415</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 6">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000011">
        <property type="protein sequence ID" value="CUP35824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000026">
        <property type="protein sequence ID" value="MZL33788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000024">
        <property type="protein sequence ID" value="MZS89856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000038">
        <property type="protein sequence ID" value="VUX65632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708139.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000128_gene276"/>
    <dbReference type="EnsemblBacteria" id="CUN57809">
        <property type="protein sequence ID" value="CUN57809"/>
        <property type="gene ID" value="ERS852478_00511"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP35824">
        <property type="protein sequence ID" value="CUP35824"/>
        <property type="gene ID" value="ERS852523_01361"/>
    </dbReference>
    <dbReference type="GeneID" id="66492751"/>
    <dbReference type="eggNOG" id="COG0421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="PTHR11558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="7">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="3">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Spermidine binding" evidence="3">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN57809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP35824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL33788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS89856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX65632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="286" mass="33523" checksum="C0012770CC618D31" modified="2016-09-07" version="1">MELWYSEFHTGNVKLSVRINRQLFSGESEFQRIDVFESEEFGRFVALDGEIVFSDKDEFIYDEMVTHVPMTVHPNVKNVLIIGGGDGGVARELIHYPQIESIDVVESDKMFVDVCAEMFPDIAQGLKDERVNIYYEDGLRFLRNKKARYDLIINDSTDPLGHTEGLFTKEFYGSCYKALRDDGIMVYQHGSPFYDEDEVECRKMHRKVFRSFPVSRVYQAHIPTCPSGYWLFGFASKKYHPLEDFRPERFDNLNIETWYYTTNLHRGAFMLPKYVEDLLEEEENSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MUK6</accession>
    <name>A0A174MUK6_9FIRM</name>
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        <submittedName>
            <fullName evidence="4">DUF1294 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Protein of uncharacterized function (DUF1294)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_03593</name>
        <name evidence="2" type="ORF">ERS852478_02957</name>
        <name evidence="3" type="ORF">ERS852523_01494</name>
        <name evidence="5" type="ORF">GT712_01840</name>
        <name evidence="4" type="ORF">GT728_07325</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
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        </lineage>
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    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUP39963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZL33016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="ERS852478_02957"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP39963">
        <property type="protein sequence ID" value="CUP39963"/>
        <property type="gene ID" value="ERS852523_01494"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="DUF1294"/>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="57"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO48284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP39963.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZL33016.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZS87865.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VUX67318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="97" mass="10838" checksum="04205FFF41F89FBC" modified="2016-09-07" version="1">MTSTNLLYIYVIIINVVTFFIYGLDKSRAKAGQWRIPEAQLIFLAVIGGSVGALAGMKVFHHKTRKPKFKTGVPAILIIQLIIYFLFSGNEGIILRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NBY9</accession>
    <name>A0A174NBY9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon dioxide concentrating mechanism protein CcmL</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ethanolamine utilization protein EutN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ccmL</name>
        <name evidence="5" type="ORF">BWLFYP14_01559</name>
        <name evidence="1" type="ORF">ERS852478_02313</name>
        <name evidence="2" type="ORF">ERS852523_01628</name>
        <name evidence="4" type="ORF">GT712_12795</name>
        <name evidence="3" type="ORF">GT728_12240</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP44108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000029">
        <property type="protein sequence ID" value="MZL33948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000086_gene4010"/>
    <dbReference type="EnsemblBacteria" id="CUO26642">
        <property type="protein sequence ID" value="CUO26642"/>
        <property type="gene ID" value="ERS852478_02313"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP44108">
        <property type="protein sequence ID" value="CUP44108"/>
        <property type="gene ID" value="ERS852523_01628"/>
    </dbReference>
    <dbReference type="GeneID" id="66494430"/>
    <dbReference type="eggNOG" id="COG4576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01614">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004992">
        <property type="entry name" value="EutN_CcmL"/>
    </dbReference>
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        <property type="entry name" value="EutN_CcmL_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03319">
        <property type="entry name" value="EutN_CcmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159133">
        <property type="entry name" value="SSF159133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51932">
        <property type="entry name" value="BMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO26642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP44108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="88" mass="8947" checksum="197EF884FF5DB152" modified="2016-09-07" version="1">MIVGKVVGSVVSTRKSEKLIGSKFMIIEPVHHMKGDLSQLVAIDMIGAGVGEYVLVAQGSAARIGCGVETAPVDAAIVGIIDDGAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QPU5</accession>
    <name>A0A174QPU5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0297 protein BWLFYP14_00352</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BWLFYP14_00352</name>
        <name evidence="3" type="ORF">ERS852478_01072</name>
        <name evidence="4" type="ORF">ERS852523_02687</name>
        <name evidence="6" type="ORF">GT712_13585</name>
        <name evidence="5" type="ORF">GT728_14255</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0297 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000030">
        <property type="protein sequence ID" value="CUP75264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000037">
        <property type="protein sequence ID" value="MZL34329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000028">
        <property type="protein sequence ID" value="MZS90075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994102.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000035_gene3836"/>
    <dbReference type="EnsemblBacteria" id="CUN79139">
        <property type="protein sequence ID" value="CUN79139"/>
        <property type="gene ID" value="ERS852478_01072"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP75264">
        <property type="protein sequence ID" value="CUP75264"/>
        <property type="gene ID" value="ERS852523_02687"/>
    </dbReference>
    <dbReference type="GeneID" id="66496225"/>
    <dbReference type="eggNOG" id="COG4472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01507">
        <property type="entry name" value="UPF0297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009309">
        <property type="entry name" value="IreB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40067">
        <property type="entry name" value="PTHR40067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06135">
        <property type="entry name" value="IreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037258">
        <property type="entry name" value="DUF965_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN79139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP75264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL34329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS90075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX67507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="90" mass="10519" checksum="E6E08D03B8C0A405" modified="2016-09-07" version="1">MAENNLGNTQYFRTKPDQELQVKEVLDLVYTAMDEKGYNPVNQIVGYIMSGDPTYITSHKGARSMIMKVERDELVEELLNEYIKNKSWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QUU9</accession>
    <name>A0A174QUU9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inner membrane ABC transporter permease protein ycjP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ycjP_14</name>
        <name evidence="7" type="synonym">ycjP_4</name>
        <name evidence="7" type="ORF">ERS852478_00419</name>
        <name evidence="8" type="ORF">ERS852523_02752</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
            <strain evidence="8 10">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000031">
        <property type="protein sequence ID" value="CUP76992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000034_gene3889"/>
    <dbReference type="EnsemblBacteria" id="CUN53977">
        <property type="protein sequence ID" value="CUN53977"/>
        <property type="gene ID" value="ERS852478_00419"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP76992">
        <property type="protein sequence ID" value="CUP76992"/>
        <property type="gene ID" value="ERS852523_02752"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="94"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN53977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP76992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="295" mass="32852" checksum="F9A144E0D2D37BB7" modified="2016-09-07" version="1">MRKVMQIFRIRKIGSLLLVLLALVAIFPVFFSVTGSLMGQKELNDLLGAVLTADSGSASGQAVSYVFWRVLPLYPTLRSYVKVLLDSPEFFVMFWNSVKITVGVLAGQILVGVPAAWGFARYRFPGKNLLFMIYVALMMMPFQVMMLSNYLVLDQMKLLDHLWGIILPAAFSTFPVFIMYRFFESIPEALMESARLDGAGELLIFIRIGIPLGSAGIISALVLGFLEYWNLIEQPMAFLKTKSLWPLSLYLPQIDISQTGKAFAVSVLVLIPAVIVFLAGQDYLEQGIISTAIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SY18</accession>
    <name>A0A174SY18_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[Ribosomal protein S18]-alanine N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.266</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">paiA</name>
        <name evidence="3" type="synonym">paiA_2</name>
        <name evidence="5" type="synonym">rimI</name>
        <name evidence="7" type="ORF">BWLFYP14_02880</name>
        <name evidence="3" type="ORF">ERS852478_02833</name>
        <name evidence="4" type="ORF">ERS852523_03589</name>
        <name evidence="6" type="ORF">GT712_17625</name>
        <name evidence="5" type="ORF">GT728_14505</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acetylates the N-terminal alanine of ribosomal protein S18.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N-terminal L-alanyl-[ribosomal protein bS18] = CoA + H(+) + N-terminal N(alpha)-acetyl-L-alanyl-[ribosomal protein bS18]</text>
            <dbReference type="Rhea" id="RHEA:43756"/>
            <dbReference type="Rhea" id="RHEA-COMP:10676"/>
            <dbReference type="Rhea" id="RHEA-COMP:10677"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64718"/>
            <dbReference type="ChEBI" id="CHEBI:83683"/>
            <dbReference type="EC" id="2.3.1.266"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. RimI subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.266" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000056">
        <property type="protein sequence ID" value="CUQ00598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000038">
        <property type="protein sequence ID" value="MZL34378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000052">
        <property type="protein sequence ID" value="MZS90828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000064">
        <property type="protein sequence ID" value="VUX66503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705878.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000066_gene3221"/>
    <dbReference type="EnsemblBacteria" id="CUO44506">
        <property type="protein sequence ID" value="CUO44506"/>
        <property type="gene ID" value="ERS852478_02833"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ00598">
        <property type="protein sequence ID" value="CUQ00598"/>
        <property type="gene ID" value="ERS852523_03589"/>
    </dbReference>
    <dbReference type="GeneID" id="66494776"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO44506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUQ00598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL34378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS90828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="145" mass="16800" checksum="FEC04F97C6E0713E" modified="2016-09-07" version="1">MILREMLVDDLDQVMEIEQDLFHVPWTKEGFFTFLTRDDAMFLVVEEKEKILGYCGLLMVLDEGDITNVAVRRDRQKEGIGAFLMQSLIRLAAEREVTTIHLEVRVGNETAIRLYERMGFTGDGIRKAYYSDPVEDALLMTRHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WRE2</accession>
    <name>A0A173WRE2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN42083">
        <property type="protein sequence ID" value="CUN42083"/>
        <property type="gene ID" value="ERS852478_00047"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN42083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="233" mass="26378" checksum="47D3F2427FFC502A" modified="2016-09-07" version="1">MKDHNQHEIQMSEAFLNSAFLALSGGFQDAYTYNARNEVFCNAQTGNVVLMSQHFMAGEVTAGLGYFFPIISFALGVWVAEKIQANYKYAQKLHWRQGVLLAEILILFTVGFLPTEYNMLANAMASFACAMQVQSFRKVNGYSYASTMCIGNLRSGTAALSVYFREKKSKQLKQAMYYFGIILMFALGAGIGGNLSIRYGIRMIWVSCGFLMISFLLMFIEKYKHFHEEHEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WTY1</accession>
    <name>A0A173WTY1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative electron transport protein yccM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yccM_1</name>
        <name evidence="7" type="ORF">ERS852478_00075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199490.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN42982">
        <property type="protein sequence ID" value="CUN42982"/>
        <property type="gene ID" value="ERS852478_00075"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN42982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="258" mass="28723" checksum="1DC475F463BC1048" modified="2016-09-07" version="1">MKKKQRKVRLIRAAIQLIFFIAAPSLFSTAFAGVKSIFLAIGGQQSVTWNSFLDITALLLIITILFGRHFCGYACAFGSLGDALYELTAFIRAKCFGKKKKHGYPEEWVHRLQKVKYVLLTFLLLSCITGFYSKLQGMSPWDVFSMLTTGRLPKSTYIAGTVLLILIMVGMCTQERFFCQFLCPMGAVFAIMPIIPGALFKRNRPNCAQKCTLCKKRCPAHLDIDGDTAHSGECICCHACTAVCPRKNIHTGTVIDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WUZ1</accession>
    <name>A0A173WUZ1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gltA</name>
        <name evidence="6" type="ORF">ERS852478_00086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199496.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43303">
        <property type="protein sequence ID" value="CUN43303"/>
        <property type="gene ID" value="ERS852478_00086"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN43303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="461" mass="52457" checksum="F2750311C9B5197D" modified="2016-09-07" version="1">MEKHEMMSLEDSGQLRDKIRFFEQELLKNHHIDPNLYVEYNVKRGLRDSAGKGVLTGLTEISDVNGYNLINGRQIPADGRLYYQGINVQDIISGLNGRRFGFEETIYLLIFGKLPDKEELSRFLDMMSDMEELGGRFVRDVVMKGTNANIMNAMQRCVLALYTYDDNPEDISPENVLRQSLELIAKLPEIAVYSYHAYRHFRKDDTLFIRNPQKGLSLAENILLMLRPDGKYTELEAKVLDIALILHAEHGGGNNSTFTTHVVTSSGTDTYSSTAASIGSLKGPRHGGANLKVQNMFADLKSHVDQDHWDNEDEIIAYLQKVLNKEAFDHAGLIYGMGHAVYTLSDPREVILKRFAQALAEEKGMTEEFELYNRVENIAGKLIMEHRKLFKNVCANVDFYSGFVYSMLGIPEELFTPIFAIARMPGWSAHRLEELINANKIIRPAYKYVGHHTDFVAFDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WYS0</accession>
    <name>A0A173WYS0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tricarballylate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059503.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44759">
        <property type="protein sequence ID" value="CUN44759"/>
        <property type="gene ID" value="ERS852478_00139"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015030" evidence="1">
        <location>
            <begin position="23"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN44759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="396" mass="43369" checksum="8C2B96915E73C68E" modified="2016-09-07" version="1">MKKRQVVITGAGACGLMAAIMAARNGAAVTVLEQNEKPGKKICATGNGRCNFSNLARPDDAYRGEHPEFVEDALREFSVQNTIEFFKEIGIYPLNRNGYLYPRSNQAQSVVDVLCMEAASLGVKIKTNEQVTEIKTGTNGKNFQILTKGWHYDADALILANGSRASSVSGSDGSGYMLAESFHHRIVPVYPALTALKCKGSSFKAWAGVRTEGEISLFTDGKFCKSEHGELQLTEYGISGIPVFQLSTYAVRAVREGHKAELRINFMPELSEEELKKLLYARKKACPYKKEKELLVGLFPEKLIKILISQKQLVSAIREFPLEVQDGMSFSQAQVCSGGVDTSQVNSQTMESKLCRGLYFAGELLDIDGTCGGYNLQWAWSSGAVAGKNAAKEEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X140</accession>
    <name>A0A173X140_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation protein YqfD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45461">
        <property type="protein sequence ID" value="CUN45461"/>
        <property type="gene ID" value="ERS852478_00167"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010690">
        <property type="entry name" value="YqfD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06898">
        <property type="entry name" value="YqfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN45461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="393" mass="45691" checksum="25C3C6FE94921611" modified="2016-09-07" version="1">MKFLKLIYGYVIILVRGENLERFLNLCKSRKVYMEKIRYREDGQLMAQMQAADFFRLRPLRNKTGVHIQIIQKRGMPFFFLRNKKRKAFFTGMILGGILIFFLTGRIWNIHIEGNVRNSTGEILDFLDTQDINHGMSKKKINCSEVAAAVRKNFPEITWVSARIEGTRLILNIQEGIIPQKTNSNTSPCNLLADKDGVITDMIVRRGIPVKKPGDSCKKGELLVSGELHIMNDSQEVLRKEYVHADADIFISRQISYYQEFPLKYRTEIPAGKKKKEMYFRFGHWYLGLHPALHTGQKRITEEIPLRITENFILPVWIGWTETTDYTVKEETYTRKEAEKEAVRRFHQYEKKLLQNGIKISENHITTRLTESLCITGGTLLIIEQTGEKSRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X3G0</accession>
    <name>A0A173X3G0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2Fe-2S iron-sulfur cluster binding domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Carbon monoxide dehydrogenase small chain</fullName>
            <ecNumber evidence="3">1.2.99.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cutS</name>
        <name evidence="3" type="ORF">ERS852478_00194</name>
        <name evidence="4" type="ORF">GT712_00490</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.99.2" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381429.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46154">
        <property type="protein sequence ID" value="CUN46154"/>
        <property type="gene ID" value="ERS852478_00194"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN46154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS87605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="166" mass="18549" checksum="50C26306B03D94B8" modified="2016-09-07" version="1">MKKQMQLVRCTVNGREVEEYVDVRESLLDMLRNRLGLTSVKKGCEVGECGACTVIIDGETIDSCIYLAVWAEGKNIRTLEGLEKNGELTRIQEAFIEEGAIQCGFCTPGFIMSATVLLEHGEKLSRDAIRKHMAGNLCRCTGYENIVNAVEKVMDENETRRGKTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X3K1</accession>
    <name>A0A173X3K1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutamate synthase [NADPH] small chain</fullName>
            <ecNumber evidence="6">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gltD_1</name>
        <name evidence="6" type="ORF">ERS852478_00199</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052749.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46331">
        <property type="protein sequence ID" value="CUN46331"/>
        <property type="gene ID" value="ERS852478_00199"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017701">
        <property type="entry name" value="Se_rdtase_YgfK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03315">
        <property type="entry name" value="Se_ygfK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="902"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN46331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="999" mass="110077" checksum="52FB0252CD127869" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X442</accession>
    <name>A0A173X442_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GtrA family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">GtrA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_00206</name>
        <name evidence="9" type="ORF">GT712_00430</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381055.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46531">
        <property type="protein sequence ID" value="CUN46531"/>
        <property type="gene ID" value="ERS852478_00206"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="15"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN46531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS87593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="138" mass="15961" checksum="D3121A54A9ACFD00" modified="2016-09-07" version="1">MKQWIRKMYESSVIRYIFFGGCTTMVNLVSFFILRKLKVELNIANIISIILAILFAYVVNSKYVFQDKCETLKDHVQPFCKFVSARLITMVIEVGGVWLLVSVMGLNDMIGKFLTQFIVLILNYVFSKFFVFTTGKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X5H7</accession>
    <name>A0A173X5H7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">NlpC/P60 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_00225</name>
        <name evidence="7" type="ORF">GT712_00340</name>
        <name evidence="6" type="ORF">GT728_05865</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">BIOML-A1</strain>
            <strain evidence="7 9">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN47042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381033.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN47042">
        <property type="protein sequence ID" value="CUN47042"/>
        <property type="gene ID" value="ERS852478_00225"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252377" evidence="3">
        <location>
            <begin position="40"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="391"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN47042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL32744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS87575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="635" mass="68313" checksum="21699C4EB2BA1595" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X7K0</accession>
    <name>A0A173X7K0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pyruvate synthase subunit porA</fullName>
            <ecNumber evidence="14">1.2.7.1</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Pyruvate:ferredoxin (Flavodoxin) oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">porA</name>
        <name evidence="15" type="synonym">nifJ</name>
        <name evidence="14" type="ORF">ERS852478_00209</name>
        <name evidence="15" type="ORF">GT712_00415</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 3 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.1" evidence="14"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059496.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46615">
        <property type="protein sequence ID" value="CUN46615"/>
        <property type="gene ID" value="ERS852478_00209"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037112">
        <property type="entry name" value="Pyrv-flavodox_OxR_EKR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019456">
        <property type="entry name" value="Pyrv-flavodox_OxRtase_EKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011895">
        <property type="entry name" value="Pyrv_flavodox_OxRed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10371">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000159">
        <property type="entry name" value="NifJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00890">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02176">
        <property type="entry name" value="pyruv_ox_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="685"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="739"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="969"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="998"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="694"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="697"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="700"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="704"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="748"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="751"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="754"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="758"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="819"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="822"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="824"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="847"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1078"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009032"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN46615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZS87590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="1178" mass="127235" checksum="635F80F835DF2289" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XHN6</accession>
    <name>A0A173XHN6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ski2-like helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199560.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50516">
        <property type="protein sequence ID" value="CUN50516"/>
        <property type="gene ID" value="ERS852478_00306"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C"/>
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        <property type="entry name" value="DEAD"/>
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    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
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    <dbReference type="PROSITE" id="PS51192">
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    </dbReference>
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    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="107"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN50516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="773" mass="90099" checksum="D4AD0899FC58EF45" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XIQ6</accession>
    <name>A0A173XIQ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Energy-coupling factor transporter transmembrane protein NikQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nikQ</name>
        <name evidence="6" type="ORF">ERS852478_00345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199580.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51731">
        <property type="protein sequence ID" value="CUN51731"/>
        <property type="gene ID" value="ERS852478_00345"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN51731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="274" mass="30420" checksum="C85F9B4CCF3A9541" modified="2016-09-07" version="1">MNDHKKEETMLPDWMCSGETYVPSKDKEAFLTKSTKSVLSVLAKMRFYEGKDGKFSATPSLKLFYTLLYIVLTACSGNYLFTLIMCAAVTVRLAFFSAKAIRQILRGTAGAVLFSILILLPSVFMGTPQTLMNITSRVYVSVTLVGILSSGTSWNKLTGSMRTFRLPSIFIFTLDITLKYISVLGEMCAAILTSVRLRSVGKNPQKAKALSGVLGISFLKSGEMAEEMHTAMCCRGFTGEYKKKQKYTLCAADIFSTFIMAGCIVLFWYLNRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XJ78</accession>
    <name>A0A173XJ78_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Energy-coupling factor transporter probable substrate-capture protein NikMN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nikMN</name>
        <name evidence="9" type="ORF">ERS852478_00344</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199579.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51693">
        <property type="protein sequence ID" value="CUN51693"/>
        <property type="gene ID" value="ERS852478_00344"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025937">
        <property type="entry name" value="PDGLE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13190">
        <property type="entry name" value="PDGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="PDGLE" evidence="8">
        <location>
            <begin position="235"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN51693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="334" mass="35261" checksum="D9EE019DE7C15A0A" modified="2016-09-07" version="1">MHIPENYLSPSTCAVMTAAMLPVWGYSIHKIKTEIPKSKMPLLGIGAAFSFLGMMFNVPLPGGTTGHAVGGTLIAILTGSPAAGCISVSIALLIQALLFGDGGILAFGANCFNMAFILPYLGFFLYKLLLKKTGMRKLSAAIGSYIGINAAAFCAAVEFGIQPLLFKNAEGQALYCPYPLSVSIPAMMIGHITLFGLAEIILTVVVLTFVEKVTPKALDVVPDKTAFKPLYILMAVLIVLTPLGLLATGTAWGEWGADEIAGLVSGGSQLGYTPSGMTNGFELSTLFPDYSMSGLPEWTGYILSAIVGVALLVIIFKIISSMMKEKVDFKKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y5H2</accession>
    <name>A0A173Y5H2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Argininosuccinate synthase</fullName>
            <ecNumber evidence="2 9">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">argG</name>
        <name evidence="14" type="ORF">BWLFYP14_03312</name>
        <name evidence="10" type="ORF">ERS852478_00557</name>
        <name evidence="11" type="ORF">ERS852523_03060</name>
        <name evidence="13" type="ORF">GT712_13375</name>
        <name evidence="12" type="ORF">GT728_05100</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">2789STDY5834863</strain>
            <strain evidence="11 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 19">BIOML-A1</strain>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="2 9"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000038">
        <property type="protein sequence ID" value="CUP85900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000009">
        <property type="protein sequence ID" value="MZL32596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000027">
        <property type="protein sequence ID" value="MZS90037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX67035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706208.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000024_gene288"/>
    <dbReference type="EnsemblBacteria" id="CUN59169">
        <property type="protein sequence ID" value="CUN59169"/>
        <property type="gene ID" value="ERS852478_00557"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP85900">
        <property type="protein sequence ID" value="CUP85900"/>
        <property type="gene ID" value="ERS852523_03060"/>
    </dbReference>
    <dbReference type="GeneID" id="66493132"/>
    <dbReference type="eggNOG" id="COG0137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="8"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN59169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP85900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL32596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS90037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX67035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="408" mass="45411" checksum="2136C5EB8B9190B1" modified="2016-09-07" version="1">MKEKVVLAYSGGLDTTALIPWLKETFDYDVVCCCVNCGQGNELDGLDERAKLSGASKLYIEDIVDEFCDDFIVPCVQAGAVYEHKYLLGTSMARPAIAKKLVEIARKEGAVAICHGATGKGNDQIRFELGIKALAPDIKIIAPWRMTDKWTMQSREDEIAFCKAHGIDLPFDASHSYSRDRNLWHISHEGLELEDPSQAPNYDNMLVLGVTPEKAPDKETEVTMTFEQGVPKTLNGKEMKVSEIITELNKLGGENGIGIVDIVENRVVGMKSRGVYETPGGTILMAAHEQLEELTLDRETMETKKKLGSQFAQVVYEGKWYTPLREAIQAFVESTQKYVTGEVKFKLYKGNIIKAGTTSPYSLYNESLASFTTGDLYDHHDADGFITLFGLPLKVRAMMLKEVEQNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y7V0</accession>
    <name>A0A173Y7V0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="4">4.1.99.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">moaA_2</name>
        <name evidence="15" type="synonym">moaA</name>
        <name evidence="14" type="ORF">ERS852478_00581</name>
        <name evidence="15" type="ORF">GT728_05205</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000009">
        <property type="protein sequence ID" value="MZL32617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053031.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59974">
        <property type="protein sequence ID" value="CUN59974"/>
        <property type="gene ID" value="ERS852478_00581"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="4"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN59974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL32617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="324" mass="36131" checksum="4763992CB45A830E" modified="2016-09-07" version="1">MIDKYGREIDYLRISLTDRCNLRCIYCMPEEGVKSLSHAEILTYDEILRICRCAADLGIRKIKLTGGEPLVRKGCASLAKQIKAIPGIEKVTLTTNGILLAEQLDALLDAGIDAINISLDTLDPELFKKVARRDGLEKVFEGIEAALAHPGLSLKINSVPVIKEKENFIGIAGLAQKYPIHVRFIEMMPIGFGKQFPFQDEESIKAVLEEAYGPMHAVNERYGNGPCHYYEIAGFKGKIGFISAMTHKFCSQCNRVRLTSEGFMKGCLQYQKGTDLRGLMRGGCTDSELKKAIYQVIWNKPVSHNFYEAKTEQDEIRGMSQIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YAV0</accession>
    <name>A0A173YAV0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.87</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">arnB</name>
        <name evidence="4" type="ORF">ERS852478_00620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.87" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706122.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61321">
        <property type="protein sequence ID" value="CUN61321"/>
        <property type="gene ID" value="ERS852478_00620"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099620">
        <property type="term" value="F:UDP-4-amino-4-deoxy-L-arabinose aminotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012749">
        <property type="entry name" value="WecE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02379">
        <property type="entry name" value="ECA_wecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN61321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="376" mass="43202" checksum="4C8C9DB450DA986C" modified="2016-09-07" version="1">MIDFNRPAFTGREFDYIRDAVQRGMLCGDGEYTKRCSQWMMDKFHVNHVMLTTSCTHALEMAAHLCDIKPGDEVIMPSYTFVSTADAFVLKGAKIVFVDIRPDTMNIDEKLIEAAVTEKTKVIVPVHYAGVACEMDTIMEIAKKYNLKVVEDAAQGVDACYKGKALGTIGDFGCYSFHETKNYTMGEGGAILFNRDEYLEKAEILREKGTDRSKFFRGQIDKYRWIDYGSSYLPSELNAAYLYAQLEARDQIFAKRMEIYNYYHKNLAHLAQEGKIEQPYVPEECSHNAHMYYIKVRDIQVRTRLIAYLREKGICSVFHYVPLHSAPAGQKFGRFSGEDVYTTKESERLLRLPMFYNLDMEDVKYITDTIASFDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YCM6</accession>
    <name>A0A173YCM6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative serine protease HhoB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hhoB</name>
        <name evidence="7" type="ORF">ERS852478_00635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199729.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61872">
        <property type="protein sequence ID" value="CUN61872"/>
        <property type="gene ID" value="ERS852478_00635"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="362"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN61872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="471" mass="49684" checksum="4652E6B340C63D8B" modified="2016-09-07" version="1">MNDERNLGEKTDDSGQQPRYEHYQFHEEQGTVLKPSGPSGHRRNQNSFQKKAGATIALAVIFGLVAAVVFQAANFAADRFLNTGKSSVQIKTTDSVDLQETASDDSTADKVLSDSENGTVAAVAQASMPSVVAITTVSVQEIPSFFGYSSHQYKSASTGSGIIVGDNDDELLIATNNHVVDGATTLSVCFIGDDVANAETETVNAGDNGDLNVEDAVSAKIKGTDADNDLAVVAVKKSDIPEDTLNQIKIAQIGSSDDLAVGQQVVAIGNALGYGQSVTSGWISALNRTISTDDGTNSTGLIQTDAAINPGNSGGALLNMKGELIGINSAKYADSAVEGMGYAIPISKAKPILEELMNRETREKVDSSKKGYLGVSLANLTTEAIEMYNMPTGAFVRSVEDDSPAQEAGICKGDIIVKFDGQKVSDGDDLLDKLQYYKSGEKIEAVIARATNGEYEENTVELTLGTRPDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z7S0</accession>
    <name>A0A173Z7S0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199832.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71843">
        <property type="protein sequence ID" value="CUN71843"/>
        <property type="gene ID" value="ERS852478_00875"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8M5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016671" evidence="1">
        <location>
            <begin position="26"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN71843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="817" mass="92483" checksum="97F732429C845678" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZPG9</accession>
    <name>A0A173ZPG9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein YxdL</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Lipoprotein-releasing system ATP-binding protein LolD</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lolD_2</name>
        <name evidence="6" type="synonym">yxdL_1</name>
        <name evidence="6" type="ORF">BWLFYP14_00329</name>
        <name evidence="5" type="ORF">ERS852478_01049</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060446.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78322">
        <property type="protein sequence ID" value="CUN78322"/>
        <property type="gene ID" value="ERS852478_01049"/>
    </dbReference>
    <dbReference type="GeneID" id="66496201"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN78322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX67484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="255" mass="28050" checksum="8E546A69D78E54A0" modified="2016-09-07" version="1">MALLEVTNIKKIYSTRFGGNKVQALSNVTFSVEEGEFVAIMGESGSGKTTLLNILASLDRPTSGEVLLEGKNIVYLTEKEISAFRRKNLGFVFQDFNLLDTFSLRDNIYLPLVLTGEDYREMEQKIRPIAQALKITELLDKFPYEVSGGQKQRAAVARALITNPKLILADEPTGALDSKAASALLSVFGEINAEGQTILMVTHSAQAASHASRVLFIKDGEVFHQIYKGSKSRQEMYQMIADTLTILTTGGEQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZY29</accession>
    <name>A0A173ZY29_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mepA_6</name>
        <name evidence="6" type="ORF">ERS852478_01100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380904.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80135">
        <property type="protein sequence ID" value="CUN80135"/>
        <property type="gene ID" value="ERS852478_01100"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN80135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="453" mass="49128" checksum="11235E193BB8B45F" modified="2016-09-07" version="1">MQDNKNFLGTEPVGKLLLKLSIPTVIAQLINMLYNIVDRIYIGHIPGEGSLALTGVGVCMPIIMIVSAFAALVSSGGAPRASIYMGKQDNKSAENILGNCFILQIIISVILTAILLIWGRDLLLAFGASENTISYATDYMHIYAFGTLFVQLTLGMNAFITAQGFTTFSMVSVLIGAVCNIVLDPVFIFVFHMGVRGAALATVISQAISTLWVVLFLCGKKTQLHLRKKHLHLEAKVVLPCIALGLAAFIMQSSESIVTVCFNSSLLRYGGDIAVGAMTILTSVMQFAMLPLQGIAQGAQPISSYNYGAKNADRVKKTFRLLLITCLSYSVLLWAAVQLVPRVFVSIFTADTSLIEFTAPMLKIYLGGLFLFGIQIACQMTFTSLGKAVNSIIVAVVRKFVLLIPLIYIMPHMISDSTTGVYMAEPIADITAVIFTSVLFTFQFKKALAEIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZYI4</accession>
    <name>A0A173ZYI4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">T5orf172 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070102116.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80943">
        <property type="protein sequence ID" value="CUN80943"/>
        <property type="gene ID" value="ERS852478_01122"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T5orf172" evidence="2">
        <location>
            <begin position="345"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="241"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN80943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="468" mass="54460" checksum="6EE7136A97C35D2A" modified="2016-09-07" version="1">MGLFDIFRVGKIKAENNSLKQQLQELHADEYFQVKARLDSMTQEIVDNNALISKQHEELSSLTERSQKVSKQLNTQTSKINRYKELYKSIEYVLDNFLISDIQYSNCRLNPHDKKDLEALTPSISLCFHSLDVKELRKAYKENEKQIDQLMDLYKSRYTTKANKSIYSLVVIALRAELQNVLYNLKYDKLEKSIEDIKTICAKYLKIAAEGNQSIASTLTKFIGEMEYLFINTVKIEYSYYTKKEQARQEQLALKEQMRQEAEERKALETERKKIEKEETKYKIEIEKLQDSLNQSSSDTETQKLRARILELQQQLSNVIVKKDEITTLQNGKAGNVYIISNLGAFGKDVFKIGMTRRLDPQDRVNELGSASVPFKFDVHSFIFSQDAVGLEKQLHDILNEKRLNKVNLRKEFFRVDISELESIVTSIDPTAEFNKTMFAEEFHQSAEIDLSQPSNKTIWIDEEDNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A011</accession>
    <name>A0A174A011_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fabD</name>
        <name evidence="6" type="ORF">ERS852478_01141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199937.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81617">
        <property type="protein sequence ID" value="CUN81617"/>
        <property type="gene ID" value="ERS852478_01141"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="7"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN81617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="306" mass="33156" checksum="9D6E6A52FDA1B0AB" modified="2016-09-07" version="1">MSKIAFVFPGQGAQYTGMAKDFYEKYAVSRKVFENASKASGLDVEALCFEENDRLNITEYTQIAMLTAEIAILRAVEEAGIRSQVNAGLSLGEYGALVASGVMKEEDAFTVVRKRGIFMQEAYPTGGAMSAVLGTDAELIEKICNETQGIVSIANYNCPGQIVITGEETAVAAAGEALKAAGARHVIPLKVSGPFHCELLKGAGEKLGQELEKVEIQSFTVPYVTNVTAQYVTGPEQVKELLVSQVSSSVRWQQCVEQMIDDGVDTFIEIGPGKTLTGFLKKINRNVKALHVEKTEDLDEVRKECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ACJ8</accession>
    <name>A0A174ACJ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN85933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006857256.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000068.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN85933">
        <property type="protein sequence ID" value="CUN85933"/>
        <property type="gene ID" value="ERS852478_01232"/>
    </dbReference>
    <dbReference type="GeneID" id="61431738"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="4"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN85933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="61" mass="7237" checksum="4AABA861CA178741" modified="2016-09-07" version="1">MFEYMTAQEAAELWGISVRRVQRLCKENRIEGVLNINRVWLIPKSSKKPVDKRRKVTDYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AGM9</accession>
    <name>A0A174AGM9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199999.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87363">
        <property type="protein sequence ID" value="CUN87363"/>
        <property type="gene ID" value="ERS852478_01272"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN87363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="59" mass="7219" checksum="F7057E5E11C5D5A6" modified="2016-09-07" version="1">MREKFNHLYLDSHERKLLIHSLVELKNQLIQQDRYTDCIDELIFKVTNAPTKRMKIEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AH03</accession>
    <name>A0A174AH03_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5348 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01255</name>
        <name evidence="3" type="ORF">GT728_16820</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000053">
        <property type="protein sequence ID" value="MZL34808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002569164.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86778">
        <property type="protein sequence ID" value="CUN86778"/>
        <property type="gene ID" value="ERS852478_01255"/>
    </dbReference>
    <dbReference type="GeneID" id="56804008"/>
    <dbReference type="GeneID" id="62695352"/>
    <dbReference type="GeneID" id="63967684"/>
    <dbReference type="eggNOG" id="ENOG5032RXG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035255">
        <property type="entry name" value="DUF5348"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17295">
        <property type="entry name" value="DUF5348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5348" evidence="1">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN86778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="73" mass="8612" checksum="95E77394137B64A2" modified="2016-09-07" version="1">MAQKMTGALVFDERTDRYDIRFDLNSYYGGLHCGECFDVFVRGKWKPTRIEYGDNWYLVGIRAEDLNGLRVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AMB4</accession>
    <name>A0A174AMB4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Degradation activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">degA_2</name>
        <name evidence="6" type="ORF">ERS852478_01329</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200017.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89363">
        <property type="protein sequence ID" value="CUN89363"/>
        <property type="gene ID" value="ERS852478_01329"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN89363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="343" mass="39172" checksum="49768993C9DC46ED" modified="2016-09-07" version="1">MITIKEMAEMLGISTTTVSNVINGKTSEVSQKTAEKVQKLLDEYDYVPNMSAKNLAQNHSRLIGIVLKGRKDKYENIFADPFHGELLGALEAAIREHGYYMMLYTSEDINEIVRNVVSWNTEGLILIGMLHDDYLRIKSKYKNPVVLIDSYTPKNIAKYVNIGLDDEQGGYLMTKYLLECGHRKIAFLADNMEGVDYIRYTGHQRALQEYNIDVDLDNLIVIRPSKYERQGSMEEIYAVAHKFTAFMCCSDYYAVTLMKYLRERGIRFPEDLSITGFDDNLYAQVVSPPLTTIHQNISQRGTMAVEYLLRMIDGWAPKSTSITLPVKLVVRDSVKILNSDKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174APA7</accession>
    <name>A0A174APA7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oligo-1,6-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">malL_2</name>
        <name evidence="3" type="ORF">ERS852478_01328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200016.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89318">
        <property type="protein sequence ID" value="CUN89318"/>
        <property type="gene ID" value="ERS852478_01328"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="13"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN89318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="559" mass="65149" checksum="0734001EFB6C001C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AVL3</accession>
    <name>A0A174AVL3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator immR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">immR_3</name>
        <name evidence="2" type="ORF">ERS852478_01390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN92597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200049.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN92597">
        <property type="protein sequence ID" value="CUN92597"/>
        <property type="gene ID" value="ERS852478_01390"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN92597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="181" mass="20112" checksum="E09CD0131075DFA6" modified="2016-09-07" version="1">MTISKRIKSLRSESGLRQSELGKAVGVSSQVISNIERGYTRPSTELVNRCAKYFGVPADYLLGRTTEKYSTTEQKEAPTLSAKIKDRMDQLQLNQSDLITKSEISEDSFEGIMAGTVIPGIDVAGRLSKALDTSIDYLIGNSAFSCAIASEDEQDIILKFRKMSKRGKRLFLAMMEELEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AYC4</accession>
    <name>A0A174AYC4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN92979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704651.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN92979">
        <property type="protein sequence ID" value="CUN92979"/>
        <property type="gene ID" value="ERS852478_01403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025624">
        <property type="entry name" value="PcfK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14058">
        <property type="entry name" value="PcfK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN92979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="253" mass="28660" checksum="7764B1A39765E24D" modified="2016-09-07" version="1">MSEQLKQEVDTAEIDRLETETDVDSKTIGQDETELLESKLEDESGNEVKAEDTVYLGKASLAEILTGMADPTEEEIRAAEIENAKPVKQKAKEKLEAEKKKATQKNFAEPIIAYLLKRCEEDQGLAEDVMQEGKTWNKCFNYIVEQARKQSNGRSTAVEDQVVYEWAEDYYHKYEKPETAKKEKDKKPATTKKTEAPAKKVTEIKKDIQETKNDSKVSEKPEKKDAASKQRKTEKTSTKSSGLNGQISLFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B4P7</accession>
    <name>A0A174B4P7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ion-translocating oxidoreductase complex subunit C</fullName>
            <ecNumber evidence="9">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Rnf electron transport complex subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnfC_2</name>
        <name evidence="9" type="synonym">rnfC</name>
        <name evidence="14" type="synonym">rnfC_1</name>
        <name evidence="12" type="synonym">rsxC</name>
        <name evidence="14" type="ORF">BWLFYP14_00988</name>
        <name evidence="11" type="ORF">ERS852478_01490</name>
        <name evidence="13" type="ORF">GT712_13100</name>
        <name evidence="12" type="ORF">GT728_10955</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">BIOML-A1</strain>
            <strain evidence="13 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000024">
        <property type="protein sequence ID" value="MZL33702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000026">
        <property type="protein sequence ID" value="MZS89983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380991.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95807">
        <property type="protein sequence ID" value="CUN95807"/>
        <property type="gene ID" value="ERS852478_01490"/>
    </dbReference>
    <dbReference type="GeneID" id="66492612"/>
    <dbReference type="eggNOG" id="COG4656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00461">
        <property type="entry name" value="RsxC_RnfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010208">
        <property type="entry name" value="Ion_transpt_RnfC/RsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026902">
        <property type="entry name" value="RnfC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43034">
        <property type="entry name" value="PTHR43034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13375">
        <property type="entry name" value="RnfC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01945">
        <property type="entry name" value="rnfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN95807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL33702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS89983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX63502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="438" mass="47287" checksum="38CFC3FACBFD4E2A" modified="2016-09-07" version="1">MGILTFKGGVHPYDGKELSKNSPVVKYLPKGDMVYPLSQHIGAPAAAIVQKGDHVLAGQKIADAAGFVSSPIHSSVSGTVKGIEPRLTATGSMVNSIIIENDQQYESVEFTPARLEDLSKEEILARIKEGGVVGMGGAGFPTQVKLAPKEPEKIDHILVNGAECEPYLTSDYRRMLDDSEKLIEGLRVMLKLFDNAKGYICIEDNKPDCIAKLKEMVKDIPRIEVAELMTKYPQGGERFLIKAVTDREINSAMLPADAGCVVDNVDTVIAVYEAVILGKPVMDRIVTVTGQGIKNPQNFDVLSGTDMAELIEAAGGLTDNVSKVISGGPMMGFAMYDTHVPCIKTSSACLCLEKDDVADAEQTACINCGRCVGVCPGHVIPARLATFAEHGDMKSFQKFDGMECCECGCCSYICPAKRPLTQMIKSMRKMVLASRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B7C3</accession>
    <name>A0A174B7C3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yedK</name>
        <name evidence="8" type="ORF">ERS852478_01518</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704299.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000124.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96852">
        <property type="protein sequence ID" value="CUN96852"/>
        <property type="gene ID" value="ERS852478_01518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN96852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="192" mass="22516" checksum="14291FA52C8983F1" modified="2016-09-07" version="1">MCSRYYIDLDMMEEISRVVQNIDGRIRLTQGDIRPTDVAPVIGQSEHRLELGMCRWGYPLSKGKNPVINARVETVMDKPSFQNGILYHRLLIPAGGFYEWNSLKEKSTFTRPDSSVLYMAGFCDWFENERRFVILTTTANNSMKKIHDRMPLILEREQITDWFDNNKMPVLLRQTPTLLNRQTEYEQQSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BAW2</accession>
    <name>A0A174BAW2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA topoisomerase 3</fullName>
            <ecNumber evidence="3">5.99.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">topB_3</name>
        <name evidence="3" type="ORF">ERS852478_01546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.99.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97917">
        <property type="protein sequence ID" value="CUN97917"/>
        <property type="gene ID" value="ERS852478_01546"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Topoisom_bac" evidence="2">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN97917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="214" mass="23646" checksum="0EFD55778186A69A" modified="2016-09-07" version="1">MERAGADDLPEDAERQGLGTPATRASILEKLVQMGFVERRGKQLLPTKDGHNLACVLPEVLTSPQLTAQWETELTAIAKGQADPEGFMAGIAEMTRGLIANYSQISEDAQKLFQAERVVIGKCPRCGESVYEGKKNYYCGNRSCQFVMWKNDRFFEERGKAFTPKIAAALLKDGKAKVKGLRSMKTGKTYDGTVLLADTGGKYVNYRVEQRGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BN19</accession>
    <name>A0A174BN19_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008688169.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02037">
        <property type="protein sequence ID" value="CUO02037"/>
        <property type="gene ID" value="ERS852478_01641"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO02037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="59" mass="6911" checksum="F11CFB38E49E0B2D" modified="2016-09-07" version="1">MALKIVRRYDANGNVIEDKDLERFKLDSPVVRQILYQMNKEMGAVDNIKVDAAERRNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BQ95</accession>
    <name>A0A174BQ95_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_024720750.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01860">
        <property type="protein sequence ID" value="CUO01860"/>
        <property type="gene ID" value="ERS852478_01636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046191">
        <property type="entry name" value="DUF6219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19727">
        <property type="entry name" value="DUF6219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO01860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="68" mass="7629" checksum="2F8F2F75D1A6F1D3" modified="2016-09-07" version="1">MKSHKYWSLGALFCMLGCIYSGIKKSMTAHKYFAYSSLLCIGMSIYSGHKLVSPKKKKITESNNSENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BS47</accession>
    <name>A0A174BS47_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">rplQ</name>
        <name evidence="8" type="ORF">BWLFYP14_00283</name>
        <name evidence="4" type="ORF">ERS852478_01685</name>
        <name evidence="5" type="ORF">ERS852523_01267</name>
        <name evidence="7" type="ORF">GT712_08845</name>
        <name evidence="6" type="ORF">GT728_04835</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">2789STDY5834863</strain>
            <strain evidence="5 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 13">BIOML-A1</strain>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP32820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707287.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2955"/>
    <dbReference type="EnsemblBacteria" id="CUO03584">
        <property type="protein sequence ID" value="CUO03584"/>
        <property type="gene ID" value="ERS852478_01685"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP32820">
        <property type="protein sequence ID" value="CUP32820"/>
        <property type="gene ID" value="ERS852523_01267"/>
    </dbReference>
    <dbReference type="GeneID" id="66496149"/>
    <dbReference type="eggNOG" id="COG0203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO03584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP32820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL32545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS89174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX67442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="178" mass="20122" checksum="5AAD407A3707586F" modified="2016-09-07" version="1">MAKYRKLSRTSDQRKALLRSQVTSLLYHGKIVTTEAKAKEIRKIAEGLVAMAVREKDNFETVTVTAKVARKDAEGKRVKEVVDGKKKTVYDEVQKEIKKDAPSRLHARRQMMKVFYPVKEVPAKGAGRKKNTKDVDMVAKMFDEIAPKYADRNGGYTRIVKIGPRKGDAAMEVLIELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BUD9</accession>
    <name>A0A174BUD9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO04761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009247523.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO04761">
        <property type="protein sequence ID" value="CUO04761"/>
        <property type="gene ID" value="ERS852478_01700"/>
    </dbReference>
    <dbReference type="GeneID" id="61850124"/>
    <dbReference type="GeneID" id="66882334"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026989">
        <property type="entry name" value="TnpV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14198">
        <property type="entry name" value="TnpV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO04761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="125" mass="14664" checksum="DD88B26F395E6DD6" modified="2016-09-07" version="1">MTKTIFEEMGGTYRQVGDYLLPNITVPAEEEIEPIGLWGKRHARHLKEHYKVLYMNLLTSGKLHSYLAEVDKQAEDMFLRLVKEYADRQDVTEQLKKDNPYEWIGRMNNIQACVREVVGTELIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BWP4</accession>
    <name>A0A174BWP4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057780.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05214">
        <property type="protein sequence ID" value="CUO05214"/>
        <property type="gene ID" value="ERS852478_01712"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO05214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="103" mass="12290" checksum="31665F6568A16AC5" modified="2016-09-07" version="1">MEQILNKLSEIELTAQRIMEDCDRQKQQLSEEAEQKCKNYDEQLESRTTEQIQRIRQQLEEEKDSRLAQLRADTDATFSSLDAHYEQQHSQLSRELFEKILAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BWQ9</accession>
    <name>A0A174BWQ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gamma-D-glutamyl-L-lysine endopeptidase</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ykfC</name>
        <name evidence="5" type="ORF">ERS852478_01721</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05512">
        <property type="protein sequence ID" value="CUO05512"/>
        <property type="gene ID" value="ERS852478_01721"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018743" evidence="3">
        <location>
            <begin position="28"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="119"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO05512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="237" mass="25481" checksum="EBD89298BCE64349" modified="2016-09-07" version="1">MNNKIKTILMAAIMSSVVLTQGVCVSAAQFDDGASAFSDGTGSVSALASTLAKQTEEQTQEFVAKEEEAAQIREERRVEKAEKASEKAEQEKTAALESIQQTVEDTKKKIAEEAEAKRLAKRQEVVNFALQFEGNPYVYGGTSLTNGADCSGFVMSVFANFGYSLPRVAAAQCDASTKKDISQLEPGDLVFYGNGYIDHVALYIGDGKIIHASNAATGIKISDYDYEKPAAVGTFME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BXN6</accession>
    <name>A0A174BXN6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MOSC domain protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">MOSC domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Molybdenum cofactor biosynthesis protein MoaC /MOSC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_01172</name>
        <name evidence="2" type="ORF">ERS852478_01736</name>
        <name evidence="3" type="ORF">GT728_05780</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000009">
        <property type="protein sequence ID" value="MZL32729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705366.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05971">
        <property type="protein sequence ID" value="CUO05971"/>
        <property type="gene ID" value="ERS852478_01736"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO05971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX63813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="142" mass="15492" checksum="62D275F2AA42C4BD" modified="2016-09-07" version="1">MGKVIAVCTSERKGIQKTSVPEIKVIEDWGIEGDAHAGKWHRQVSLLSFDKIEDFRARGAEVEDGAFGENLVVQGIDFATLPIGTKFQCNDVVLELTQIGKECHSGCAIFKKMGECIMPKQGVFTKVLHGGVIHPGDELVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C2D2</accession>
    <name>A0A174C2D2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07661">
        <property type="protein sequence ID" value="CUO07661"/>
        <property type="gene ID" value="ERS852478_01790"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO07661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="45" mass="5251" checksum="97F7FC92003C89C3" modified="2016-09-07" version="1">MADYVLILGICQWQNGIQISVRHLDEISGVAEDDAMEVFENDYYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C6Z5</accession>
    <name>A0A174C6Z5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Shikimate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200276.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08049">
        <property type="protein sequence ID" value="CUO08049"/>
        <property type="gene ID" value="ERS852478_01802"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO08049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="204" mass="24397" checksum="27422B7E5EDEFAE9" modified="2016-09-07" version="1">MELKARCKERFEPVVQAIRQLQKEKEGLDEPLIVAIDGRCGSGKTTLGEYLEQVFDCNLFRMDDFFLRMEQRTPQRLKETGGNVDYERFEETVLRPIFQKQTVFYQPFSCRKWNLLEGYPVPYKKLNIIEGSYSMHPYFKNPYQLRVFLNISPKDQMENIKKRNGPEKAKQFQNMWIPKEEAYFKKFHVMDGAIQVMWNLKTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CAL4</accession>
    <name>A0A174CAL4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Domain of uncharacterized function (DUF3841)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200352.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10194">
        <property type="protein sequence ID" value="CUO10194"/>
        <property type="gene ID" value="ERS852478_01847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024211">
        <property type="entry name" value="DUF3841"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12952">
        <property type="entry name" value="DUF3841"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO10194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="182" mass="22077" checksum="0054A679585C7235" modified="2016-09-07" version="1">MRLWTTMPARVYKETIEKTGIYQCDPDKSEVLTWDDSGRQFANAYDWMSGYMTEKIGPPPEGIKYPVWAWYRLRTRQARPDLRWVEFRGAAKEMVLIELEKEDSQVVLSDEEIWPVAQLNDTAWCRNDEELDWYYNPDMEGKEKFKKESWYRVFEIDQAPHVQATFWELRKEEIKKIWKYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CPI0</accession>
    <name>A0A174CPI0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylserine decarboxylase proenzyme</fullName>
            <ecNumber evidence="5">4.1.1.65</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">psd</name>
        <name evidence="5" type="ORF">ERS852478_01978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.65" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707516.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15034">
        <property type="protein sequence ID" value="CUO15034"/>
        <property type="gene ID" value="ERS852478_01978"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0688">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PTHR10067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO15034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="304" mass="34934" checksum="7C02331431930DB0" modified="2016-09-07" version="1">MKYIDRKGNITIEENEQDKFLRHLYNDRGGRLCLKLLIRPFVSKAAGVLLNTRLSARFVPDFVKNNKIDLSIYEKQNFSSWNDFFIRRIRKEERPIDMRENILISPCDGKLSVHRISSDSRFSIKDTEYTAGQLLKNKAIAERYTGGYALIFRLTVDDYHHYCYVADGRKSANVTLPGVFHTVNPAANDVYPIYKENAREYTLLKTKQFGTILMMEVGAMMVGKITNLHKNPATVKKGQEKGNFEFGGSTIILLIQPGKVRIAYDLIENTEEGYETIVKMGERIGECRKLKNTKNHYEGTIENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CZ13</accession>
    <name>A0A174CZ13_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200496.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16826">
        <property type="protein sequence ID" value="CUO16826"/>
        <property type="gene ID" value="ERS852478_02034"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO16826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="207" mass="22788" checksum="B567C401D1175EF1" modified="2016-09-07" version="1">MTYIENVFLCMASPLLIAALCMGKRQRKFFLFCFAGMGVCLLSAYINTFFAALYKADTFAATTEIAPVVEEVMKLLPLLFYLLIFEPKREQIKNTAVVIALSFATFENVCYLIQNGAGHFSFIFFRGIGTGAMHVICGAIVGGDLAYVWQRTWLKIAGTCGLLGAAITFHAIYNLLIAYGSVAQYIAYLLPVLILAAGKLIFRSSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CZ66</accession>
    <name>A0A174CZ66_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200501.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16886">
        <property type="protein sequence ID" value="CUO16886"/>
        <property type="gene ID" value="ERS852478_02036"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO16886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="122" mass="13324" checksum="8F8882F47515C250" modified="2016-09-07" version="1">MLKNEERIAEVKRRIGEKERQQRLQHRRIVSAFCIAACFAVIVGVSFAMPGIIGRVEPGTSSGFETAATILGGSTALGYMVIGLLAFILGACVTILCFRIHQLNKEEQTEKQKEDNGDGADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CZB4</accession>
    <name>A0A174CZB4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MmcQ/YjbR family DNA-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02361</name>
        <name evidence="1" type="ORF">ERS852478_02084</name>
        <name evidence="3" type="ORF">GT712_14230</name>
        <name evidence="2" type="ORF">GT728_13930</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">BIOML-A1</strain>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO18397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000035">
        <property type="protein sequence ID" value="MZL34271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000030">
        <property type="protein sequence ID" value="MZS90194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707693.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18397">
        <property type="protein sequence ID" value="CUO18397"/>
        <property type="gene ID" value="ERS852478_02084"/>
    </dbReference>
    <dbReference type="GeneID" id="66493759"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35145">
        <property type="entry name" value="PTHR35145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO18397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL34271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="125" mass="14717" checksum="98D5E69F03EF23CF" modified="2016-09-07" version="1">MKRAELESFIMETYNAETDYPWLKYPNYEVFRHCNNRKWFALIMDVPKNKLGLQGEEMLKVVDFKCDPILIGTLREEPGFFPAYHMSKDSWITVALDGSVSDDKTKMLLDMSYEATIPKTCKKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D121</accession>
    <name>A0A174D121_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable aromatic acid decarboxylase</fullName>
            <ecNumber evidence="2">4.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pad1</name>
        <name evidence="2" type="ORF">ERS852478_02057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17556">
        <property type="protein sequence ID" value="CUO17556"/>
        <property type="gene ID" value="ERS852478_02057"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="1">
        <location>
            <begin position="3"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO17556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="58" mass="6538" checksum="9A7DC86E4BDBB8C8" modified="2016-09-07" version="1">MRKRLIIGMSGVSGAPLTIELLKQLQQYKEIIETHLIVTKGAEMTLEQIYALADEVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D5M2</accession>
    <name>A0A174D5M2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_02093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19308">
        <property type="protein sequence ID" value="CUO19308"/>
        <property type="gene ID" value="ERS852478_02093"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018337">
        <property type="entry name" value="Cell_wall/Cho-bd_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01473">
        <property type="entry name" value="Choline_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51170">
        <property type="entry name" value="CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019740" evidence="4">
        <location>
            <begin position="32"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="Cell wall-binding" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO19308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="328" mass="36882" checksum="ABC71175EB39B18F" modified="2016-09-07" version="1">MKRKRFTALKVTLTAMMLTAALTSGAGSAYAADLSQEGGSEPTVIITPSPEVTPELPLPTSTPKPTPVPKNGLLKEGKVYRYYVNNKPVRNKWKKINGKYYWFKSNGVAAHDGHYKIKGVFYLFNKNAQRIIPGKKSIVKVNGVKYFVDAKGRPVTGWNEFNGRMYYVHKNGKCATNETIGGIRFNKNGYASNLTQARCKLAARNFIARHSNANASNYEKFRSCFYYIMAYTNFVGYMDPTPQEFKTKDWVYKYSLQMFQNGLTGNCYGIASSVAAIAKELGYEPYVITIPDGHSFVMINGLYYDNMYGTLFGAATRPAYTIEHKIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D6H5</accession>
    <name>A0A174D6H5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02111</name>
        <name evidence="3" type="ORF">GT712_19610</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000084">
        <property type="protein sequence ID" value="MZS91174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055054270.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000149.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19889">
        <property type="protein sequence ID" value="CUO19889"/>
        <property type="gene ID" value="ERS852478_02111"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030KGY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038148">
        <property type="entry name" value="Tn1545/Tn916_Xis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="273"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO19889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS91174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="329" mass="38863" checksum="2666C1C212B5B8FD" modified="2016-09-07" version="1">MATAIMKQKEVPEMDDVAEIISKISEDSPYKRRPTQKRTWMTVPEMGKLLGLKKTDRYWLVHKNVFESKEIAGKIRINIASFEKWYANQIKYHKVTGEKPGKELKSWSYSVKEVADLLGVDEYLVYDLLKKNQMEAVIVDYWKRIPKESFQNWYKSQSQYRTKEDRKKDALLEDATITMPEMAQLLGTTRSAVYTILDNPKYSHFFEFIVIAEKKRITKESFQKFLEGQDRYMLDPSNDYEELAQEQNIALANFRRKKLSQTGIRGSNGNIKYLTFDEASYLAKVSRSMINKWADKGKFTVIKVGSRVRIRRDEFEDWMEQRDLERSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D9C0</accession>
    <name>A0A174D9C0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation initiation inhibitor protein soj</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">soj_3</name>
        <name evidence="2" type="ORF">ERS852478_02136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20650">
        <property type="protein sequence ID" value="CUO20650"/>
        <property type="gene ID" value="ERS852478_02136"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="2"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO20650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="275" mass="30508" checksum="503E6B82ECEE9906" modified="2016-09-07" version="1">MCKVISVVNQKGGVGKTTTTVNVGIGLAREGKKVLLIDADPQGSLTASLGYEEPDDLRITLATIMMDVINEEEISLEDGILHHQENVDFLPANIELSALEVTMGNVMSREMIMKEYIDAIRCRYDYILIDCMPSLGMMTINALVSSDSVLIPVQAAYLPMKGLQQLIKTILTVKKRLNRKLAIEGILLTMVDFRTNYARDIASRVHTTYGSQIEVFENVIPMSVKAAETSAEGKSFCLQNETRGHETPRFSDRLDFGTKCPKVQKNNGSNCGWDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DCH2</accession>
    <name>A0A174DCH2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">rsmG</name>
        <name evidence="3" type="ORF">ERS852478_02180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578457.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22029">
        <property type="protein sequence ID" value="CUO22029"/>
        <property type="gene ID" value="ERS852478_02180"/>
    </dbReference>
    <dbReference type="GeneID" id="66493372"/>
    <dbReference type="eggNOG" id="COG0357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="130"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO22029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="240" mass="26956" checksum="ABB05583ED606ECD" modified="2016-09-07" version="1">MPYNLTTLENGCRELGIELSQKQKNQFIQFYEFLVEKNKVMNLTGITEFEEVLTKHFLDSLACVKAIDMTKVKTIMDIGTGAGFPGVPLKIAFPHLEACLLDSLKKRVNFLEESFELLGLEGIKAIHGRAEEYAKNKEYREKYDLCVSRAVSNLATLSEYCLPYVKIGGTFISYKSGTVQEEAEEAEKAINILGGQVKDITYFKLPDSEIDRSLVIINKKKSTPGKYPRKAGTPLKEPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DE89</accession>
    <name>A0A174DE89_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate kinase</fullName>
            <shortName evidence="2">SK</shortName>
            <ecNumber evidence="2">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroK_2</name>
        <name evidence="2" type="synonym">aroK</name>
        <name evidence="5" type="ORF">BWLFYP14_02860</name>
        <name evidence="3" type="ORF">ERS852478_02199</name>
        <name evidence="4" type="ORF">GT728_11165</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000025">
        <property type="protein sequence ID" value="MZL33741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380404.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22629">
        <property type="protein sequence ID" value="CUO22629"/>
        <property type="gene ID" value="ERS852478_02199"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO22629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="170" mass="19055" checksum="3989F1A90A7ED982" modified="2016-09-07" version="1">MNNVTLIGMPGSGKSTIGVILAKALRYEFLDSDLLIQKQEKRKLSEIIEQDGPEKFKEIENQVNADIHVTDTVIAPGGSVIYCDEAMEHLKSIGKVIYLKLSLESLSKRLGNLKGRGVLLKDGQSLKDLYEERVPLYEKYADITIDEEGKDLDESLRAILEIIHIKEQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DFH4</accession>
    <name>A0A174DFH4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arginine decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">speA_2</name>
        <name evidence="5" type="ORF">ERS852478_02205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200610.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22795">
        <property type="protein sequence ID" value="CUO22795"/>
        <property type="gene ID" value="ERS852478_02205"/>
    </dbReference>
    <dbReference type="GeneID" id="66493396"/>
    <dbReference type="eggNOG" id="COG1982">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036633">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55904">
        <property type="entry name" value="SSF55904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="3">
        <location>
            <begin position="4"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="OKR_DC_1_C" evidence="4">
        <location>
            <begin position="361"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO22795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="488" mass="55051" checksum="7E66F72D657ADBB6" modified="2016-09-07" version="1">MERLYKKLESYGQSDYYPFHMPGHKRNRASSADDFLFERDITEISGFDNLHHAEGILKEAQEYAAQIYGTKKCFFSVNGSTAALLAAVSASVNKGGKILVARNCHKAVYHALYLRELQPVYIYPHEDQRLGINGGISPERVERYLEENTDVQAFLLTSPTYDGVVSDIKTIAEVVHRHKIPLIVDEAHGAHLHYSKYFPVSAADLGADIVIQSFHKTLPSMTQTAVLHICSDMADVEKIKRFMGIYQTSSPSYILMASMDACMDKLRKDGQQMFREFTFNLEKARQRLSKCEKIKLIEGSMIEGSGIYDFDRSKLLFSTVGTSVNGRLLHQILRDRYHIEMEMAAEKYVLGIAAVGDTEEGFERLCTAIEEIDAEIQQTDESEESQYHTSHARMTQLMTISQAVDAQQRRYSLKESVGKVSAEFAYLYPPGIPIIVPGEQITGQFVRNVRRYMEQGLEVQGLSDTSAETICVAARNEIGQEEYSPAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DID3</accession>
    <name>A0A174DID3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_01497</name>
        <name evidence="1" type="ORF">ERS852478_02268</name>
        <name evidence="3" type="ORF">GT712_11715</name>
        <name evidence="2" type="ORF">GT728_09280</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">BIOML-A1</strain>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000018">
        <property type="protein sequence ID" value="MZL33384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000022">
        <property type="protein sequence ID" value="MZS89722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705512.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25204">
        <property type="protein sequence ID" value="CUO25204"/>
        <property type="gene ID" value="ERS852478_02268"/>
    </dbReference>
    <dbReference type="GeneID" id="66493775"/>
    <dbReference type="eggNOG" id="ENOG5032ZV2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO25204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL33384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS89722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="85" mass="9537" checksum="90E6B2502A08914E" modified="2016-09-07" version="1">MFTEECINTFLENQEQLFPQAVAESYEAAEAFLEDCMAQVVDSIEEVREYLEESGADVEGMSDEELEDASEVFALPDGKYLIVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DJ45</accession>
    <name>A0A174DJ45_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mini-ribonuclease 3</fullName>
            <shortName evidence="2">Mini-3</shortName>
            <shortName evidence="2">Mini-RNase 3</shortName>
            <ecNumber evidence="2">3.1.26.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Mini-RNase III</fullName>
            <shortName evidence="2">Mini-III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">mrnC</name>
        <name evidence="4" type="ORF">ERS852478_02278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MrnC RNase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25513">
        <property type="protein sequence ID" value="CUO25513"/>
        <property type="gene ID" value="ERS852478_02278"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1939">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01468">
        <property type="entry name" value="RNase_Mini_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008226">
        <property type="entry name" value="Mini3_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="3">
        <location>
            <begin position="24"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO25513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="159" mass="17894" checksum="4F1F5AC79273F287" modified="2016-09-07" version="1">METSLNDMSGTNGLNEENLSSLKGMLHQLFHLEDKDLRTYSPLTLAYIGDGVYELVIRTILVKKGNCPVNQLHRKASSLVKAGTQSSMMEVIEPMLTEEEHSVYRRGRNAHSPTMAKHATMADYRRATGFEALMGYLYLKDDFSRIIELVRAGIGEDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DJW6</accession>
    <name>A0A174DJW6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyltransferase, YaeB/AF_0241 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059891.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25734">
        <property type="protein sequence ID" value="CUO25734"/>
        <property type="gene ID" value="ERS852478_02285"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09281">
        <property type="entry name" value="UPF0066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041369">
        <property type="entry name" value="TrmO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023368">
        <property type="entry name" value="UPF0066_cons_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040372">
        <property type="entry name" value="YaeB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818">
        <property type="entry name" value="PTHR12818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18389">
        <property type="entry name" value="TrmO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="SSF118196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00104">
        <property type="entry name" value="tRNA_TsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01318">
        <property type="entry name" value="TSAA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TsaA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO25734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="236" mass="26764" checksum="EA33536FBB5A94C1" modified="2016-09-07" version="1">MIPIAHIENDFPTKFGIPRQSGRVGALKARIVFEPEYRNVDACRGLEEFSHIWLIWEFSEAKRTKWSPTVRPPRLGGNVRKGVFATRSPFRPNSIGLSCVKLEKVALDEPDSPVLYVEGADLMNGTPIFDIKPYIPYADCHPEATGSFTEYSKDHHLNVEFPQELLERIPGESREALIAVLADDPRPAYQNDPERSYGMPFGEKDIHFRVDGDILRVYNVTEFVKKQQESSADCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DMC3</accession>
    <name>A0A174DMC3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor SigS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sigH</name>
        <name evidence="6" type="ORF">ERS852478_02276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-S contributes to the protection against external stress, thus playing a role in cellular fitness and survival.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25459">
        <property type="protein sequence ID" value="CUO25459"/>
        <property type="gene ID" value="ERS852478_02276"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016371">
        <property type="entry name" value="RNA_pol_sigma-H_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002939">
        <property type="entry name" value="RNA_polymerase_sigma-H_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="5">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO25459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="199" mass="23066" checksum="E7A946CA1D415349" modified="2016-09-07" version="1">MKQYDGIKDEELISRFKNGESEILDYLMEKYKNMVRKKARTMFLIGGENDDLIQEGMIGLFKAVRDYQPDRDAAFQTFASICVDRQIYNAIQSSNRQKHQPLNSYISLSEQDGENEEHLGDNWGENPESIIIDQENVQDLEQEITATLSPMENQVLEYYLAGNGYGEIAQIMGKTPKSIDNALQRIRIKIREQLEQYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DN08</accession>
    <name>A0A174DN08_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">ispF</name>
        <name evidence="13" type="ORF">BWLFYP14_01526</name>
        <name evidence="10" type="ORF">ERS852478_02280</name>
        <name evidence="12" type="ORF">GT712_11770</name>
        <name evidence="11" type="ORF">GT728_09225</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">BIOML-A1</strain>
            <strain evidence="12 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000018">
        <property type="protein sequence ID" value="MZL33374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000022">
        <property type="protein sequence ID" value="MZS89732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705528.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25588">
        <property type="protein sequence ID" value="CUO25588"/>
        <property type="gene ID" value="ERS852478_02280"/>
    </dbReference>
    <dbReference type="GeneID" id="66493764"/>
    <dbReference type="eggNOG" id="COG0245">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="34"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="100"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
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        </ligand>
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        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
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        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO25588.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZL33374.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZS89732.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VUX64672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="160" mass="17546" checksum="71B9982518A5E07C" modified="2016-09-07" version="1">MRVGMGYDVHRLTEDRDLILGGVKIDWEKGLLGHSDADVLIHAVMDALLGAAALGDIGKHFPDTDPAYKGISSILLLEHVTKLLREHHYEIGNIDATIIAQKPKMAPHIPQMRANMAKAMGINESQLNIKATTEEKLGFTGREEGIASQAICLLNERKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DSC2</accession>
    <name>A0A174DSC2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
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            <taxon>Clostridia</taxon>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27006">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="25"/>
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            <begin position="26"/>
            <end position="332"/>
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        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="303"/>
        </location>
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            <begin position="204"/>
            <end position="218"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="236"/>
            <end position="269"/>
        </location>
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        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO27006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="332" mass="35846" checksum="3697F6063C5B2DEE" modified="2016-09-07" version="1">MKRRFGGTVIAMVLCFILTVVSVYADDGKGQNPDYVTDYYMIVQSTQGGVDIYDEADTQSVKLNDSKISNGTAIHVLGEKNGADNKKWAYTQYHGMNGYVPMDDLDPASREEAANEEYRTFGGKDVDFEVKVHGNVSVYNGPGEKFDQVSGTEGIADGTTVHIFQHVQGEDGTNWGKTDTDGVTQGWLNLDRDTDYVNENVSADAPEATGTSGNVPVAAVTPTPEATPTPKATPTPEVTPTEKVTLTPEATPTEEATPTPEATPTEEATPTPEETEKPASTEDKESDDKQSQKTSGKNVKADSGMKNPVIWISGIGIIVIIILLIYFLKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E6Z0</accession>
    <name>A0A174E6Z0_9FIRM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32246">
        <property type="protein sequence ID" value="CUO32246"/>
        <property type="gene ID" value="ERS852478_02459"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO32246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="113" mass="13073" checksum="53830E68643A3A4A" modified="2016-09-07" version="1">MLLSPVMHTDCTNARENGKSCQVYVCATPDGKALYFARENMHNHLLFLHDIRVPATNNEAERLLKNYKRKQAQAVTFRSFENIAYLCQCMSMLVLMRLEDPANIYDRVSRIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E7S3</accession>
    <name>A0A174E7S3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
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            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578898.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33942">
        <property type="protein sequence ID" value="CUO33942"/>
        <property type="gene ID" value="ERS852478_02526"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033GEK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020521" evidence="3">
        <location>
            <begin position="43"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO33942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="501" mass="54017" checksum="1321906AAA374343" modified="2016-09-07" version="1">MSNNIRIRKNKLKGTGILAAAALTAALIAGNNIPGVTRQVSAAESQENTVSSLIPDNITLDKPVELADVELPATEYGTFEWADGSFVPAQRVQSCEVLLIPAEGQDLSHVDGWDPESGAVVGYINVIVNSITDSDNVDKTEGSGKTDPTENADPTETPETSSEKPAADENADTDNKEDKESKSDQDNKTDTDNEENKIEEDKTDNKNNKDNNSNADKTDKDTETTGKLEPADDMTQDKEDTKKDDEDGAGDNIFDNPVLPDDKDDRPTDAEDSLSDEEKEERAALNHTCDGITVSGVNLPWYVQFRVSSGDSYQFTNESDAMIFQSYEFELWDLKNNTEYEIPNGDYISVTVPVKSGYQYTIEHLLDNGATETIIPSVENGIMVFSTHSFSPFGIAGSRQLVGPDAGNDTDDTDAVTPAPASSDSQSSDSGKNNTVSVNDSSDSNNGSSSDQNDNSTENKAVKNNNTVNTGDTTSIMPFVILFVAAAVIAGVAVFIKKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E820</accession>
    <name>A0A174E820_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Sporulation-specific N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cwlC</name>
        <name evidence="4" type="ORF">BWLFYP14_00524</name>
        <name evidence="2" type="ORF">ERS852478_02529</name>
        <name evidence="3" type="ORF">GT728_13380</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO34022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000033">
        <property type="protein sequence ID" value="MZL34168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000004">
        <property type="protein sequence ID" value="VUX62659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703740.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34022">
        <property type="protein sequence ID" value="CUO34022"/>
        <property type="gene ID" value="ERS852478_02529"/>
    </dbReference>
    <dbReference type="GeneID" id="66495280"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPOR" evidence="1">
        <location>
            <begin position="180"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO34022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX62659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="254" mass="28468" checksum="362E02C8B8D9E8C4" modified="2016-09-07" version="1">MAYSIMLDAGHGGQDPGAVYKGRQEKNDNLKLALAVGEILKNKGIDISYTRTGDVYQTPFEKAQLANQAGVDYFISFHRNSSPKENQYNGAEVLIYDKSGIKYQMAENILGALGEVGFREIGVKERPGLVVLRRTRMPALLIETGFINSEEDNKLFDNKFSDIAQGIADAILGSLDEETVQEPLYYRVQTGAFRKKENADRMLYQLLEKGYPSFMLHENGLYKVQTGAYQQIGNAVNMEQRLRDDGYSTVIVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EFM1</accession>
    <name>A0A174EFM1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replication initiation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmid replication initiation factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35005">
        <property type="protein sequence ID" value="CUO35005"/>
        <property type="gene ID" value="ERS852478_02545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003916">
        <property type="term" value="F:DNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003491">
        <property type="entry name" value="Rep_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02486">
        <property type="entry name" value="Rep_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO35005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="241" mass="28693" checksum="F876BBB90319D390" modified="2016-09-07" version="1">MDALIDGGVMKRIDLAINDHTGILDIPELAEKCRKREYIGKSRSYKFYQSGELIKHREDDREYMGRTLYLGSLKSDVYFCIYEKDYEQYVKLGTPLEEADIINRFEIRLRNERAYYAVRDLLTYYDAEQTAFSIINQYVRFVDEEADKRKNDWKLNDRWAWFIGDNRQSLKLTTKPEPYTLDRTLRWVQRQVAPTLKMLKRIDKGNGTDYMKTIEQQAKLTEKHEMIIKQQTTPAKDLVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EGD0</accession>
    <name>A0A174EGD0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380780.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35616">
        <property type="protein sequence ID" value="CUO35616"/>
        <property type="gene ID" value="ERS852478_02566"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4908">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046283">
        <property type="entry name" value="DUF6320"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19845">
        <property type="entry name" value="DUF6320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO35616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="605" mass="70584" checksum="C9A7D9DFB3A4BA14" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EN67</accession>
    <name>A0A174EN67_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="9">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">lysS</name>
        <name evidence="16" type="ORF">BWLFYP14_00901</name>
        <name evidence="14" type="ORF">ERS852478_02638</name>
        <name evidence="15" type="ORF">ERS852523_02311</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">2789STDY5834863</strain>
            <strain evidence="15 18">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="16 19" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9 11">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9 11">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000023">
        <property type="protein sequence ID" value="CUP64509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707788.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000055_gene1907"/>
    <dbReference type="EnsemblBacteria" id="CUO38088">
        <property type="protein sequence ID" value="CUO38088"/>
        <property type="gene ID" value="ERS852478_02638"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP64509">
        <property type="protein sequence ID" value="CUP64509"/>
        <property type="gene ID" value="ERS852523_02311"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02800">
        <property type="entry name" value="tRNA_bind_EcMetRS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004495">
        <property type="entry name" value="Met-tRNA-synth_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="12">
        <location>
            <begin position="214"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="13">
        <location>
            <begin position="573"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO38088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUP64509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VUX63423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="678" mass="77263" checksum="0AC5A791287AFCC7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EU18</accession>
    <name>A0A174EU18_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200890.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41602">
        <property type="protein sequence ID" value="CUO41602"/>
        <property type="gene ID" value="ERS852478_02750"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO41602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="286" mass="32245" checksum="B46088476420D8D2" modified="2016-09-07" version="1">MGKKVSDFLKSEILSSVFYMAFGLCLLLVPDQTVNIICKIVFGLVMIASGIYHIVIYTAEKEKATILDLFTGVIVMVLGIFLFFTPQIVIKILPYLLGALILVDSIWKIKGSYRLKKAQRGRWKIILIGCLVFIALGVSMLLYSFLSVTRMILFSGIILTADGVADIVFLIMIRLGMKKSEKLCAEKEQEENDKEKPWDEPADPDLDEKVQDKSLNEDETEWKQDTDSQVQESEMEIETAKTADAADADAILDAEVQTPDEGVESPGREIREMLKNHDEPLEEWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EWA2</accession>
    <name>A0A174EWA2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379856.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42392">
        <property type="protein sequence ID" value="CUO42392"/>
        <property type="gene ID" value="ERS852478_02764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039444">
        <property type="entry name" value="SIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041486">
        <property type="entry name" value="STALD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011202">
        <property type="entry name" value="UCP014677"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13289">
        <property type="entry name" value="SIR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18185">
        <property type="entry name" value="STALD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014677">
        <property type="entry name" value="UCP014677"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIR2_2" evidence="1">
        <location>
            <begin position="104"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="STALD" evidence="2">
        <location>
            <begin position="249"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO42392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="472" mass="54776" checksum="B9071822C2341A20" modified="2016-09-07" version="1">MNSEINAFINKYVKEIRNNNAAFFAGAGFSKESGYVDWKTLLESIASELGLEVEKEHDLVALAQYCYNKHQNRGIINDVIFEEFSKQKEPTQNHRILARLPIGVIWTTNYDDLIEKAFDNVQKIVDVKSRNEHLSNTLANRECILYKMHGDKNNPNDAILIKDDYERYYKAHKQFLSALTGDLISKTFLFVGFSFQDPNLDYILSRIRVDYEENPRQHYAIMKSIDRKDYESDADYDYAKRRNDLFLEDLKRYRISALVIDDFSEITEILQEIERRLNQNNIFISGSAEEYGVFTKEEAENLIKLLSARLIQDEFNIISGFGVGVGSAVITGALEEIYMHNTRINNQRLLLRPFPQGKEARVLWQQYREDMISRAGISLYIFGNKKQDDNIVEANGVKTEFDIAIDAKHIVIPVGCTGYMAQKLWEQINLNIEEYYGKVNDEVRKTFQSLNTKMSNDEIVSNIVKLIKLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FCA2</accession>
    <name>A0A174FCA2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase LytC</fullName>
            <ecNumber evidence="3">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lytC_2</name>
        <name evidence="3" type="ORF">ERS852478_02928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.28" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705162.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47217">
        <property type="protein sequence ID" value="CUO47217"/>
        <property type="gene ID" value="ERS852478_02928"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="2">
        <location>
            <begin position="213"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO47217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="337" mass="36912" checksum="FBE87B8C86988839" modified="2016-09-07" version="1">MKKPSMISILLFLTGLLCIIALIFFNRTTLHQILTTEKEVDTISEQITAKHDEVKQAVDKYTTAIDTVQSNINRMKQKQQTATQKKTKEKAEIPEEASSKPSVFSQNSTSASSDSSASVFSSDAETDGHIIGIDPGHQSESVDMSAPEPNGPGSSEMKAKCTSGTQGTYSGVPEYQLNLEVSLQLKDELEQRGYQVVMTRTDNETAISNMERAQYAASQGAEIYVRIHANGDDSHTASGALTMSPSQNNPYIPQLFEQSDRLSRCIIDSYCAATGFQNLGIQYTDTMTGINWSTVPVTILEMGFMTSQNDDLKMNDAEFQKTMVQGIANGIDSYFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FDF8</accession>
    <name>A0A174FDF8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46978">
        <property type="protein sequence ID" value="CUO46978"/>
        <property type="gene ID" value="ERS852478_02918"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO46978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="77" mass="9413" checksum="239E8BBF63C1F383" modified="2016-09-07" version="1">MKNVMIPEELFGKIIKYHLLDQEQEADDIRKGLEKKLDAMVNREVYSKFKTAPTEEEREKFRQEYLDRKGMQESFRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FDG3</accession>
    <name>A0A174FDG3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058749.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPC010000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46709">
        <property type="protein sequence ID" value="CUO46709"/>
        <property type="gene ID" value="ERS852478_02907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO46709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="138" mass="15386" checksum="A8F8A9CC9060269B" modified="2016-09-07" version="1">MSKKRAPGRSLDEWMELVTECRQSGLTDAAWCNEHGISPSCFYNAVTRLRKKACQIPDPVGKASTLDLTSHKQDVVQIAIEPESSPAELIPDNGNRPMHLDNSHTIEIEADGLLIRMSNEIKPLLLKMLMDTLKESLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FEI4</accession>
    <name>A0A174FEI4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Multiple antibiotic resistance protein marA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">marA</name>
        <name evidence="5" type="ORF">ERS852478_02968</name>
        <name evidence="6" type="ORF">ERS852523_01482</name>
        <name evidence="7" type="ORF">GT712_01785</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">2789STDY5834863</strain>
            <strain evidence="6 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP39634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706276.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000028_gene194"/>
    <dbReference type="EnsemblBacteria" id="CUO48593">
        <property type="protein sequence ID" value="CUO48593"/>
        <property type="gene ID" value="ERS852478_02968"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP39634">
        <property type="protein sequence ID" value="CUP39634"/>
        <property type="gene ID" value="ERS852523_01482"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="183"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO48593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP39634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS87854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="286" mass="34297" checksum="E2659523CA88BB27" modified="2016-09-07" version="1">MLLSEQFYQTEKTGYLNEQFRLFHLKDQTRKEFSYHYHDFHKVVIFISGKAAYHIEGKAYQLKPWDILLVNRHAIHRPEIDPSVPYERFILWIQNDIPWQELLKCFQKANDRSYNLVRLNSALQEKMKDILFELENSAKSDEYGREILTQSLFLQFMVYLNRIFLEKQYIFDKKSYTFDSQIASILQYINHNLKEDLSVETLSARYYVSKYHLMRKFKQETGYTLHNYIVNKRLLMARTLISNGMPVTKAAQESGFAEYSTFSRAYRKQFKTNPSEELPHYSNPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FFT6</accession>
    <name>A0A174FFT6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="3">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">typA</name>
        <name evidence="3" type="synonym">bipA</name>
        <name evidence="5" type="ORF">ERS852478_02980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO49053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057893.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49053">
        <property type="protein sequence ID" value="CUO49053"/>
        <property type="gene ID" value="ERS852478_02980"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="6"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="18"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO49053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="610" mass="67893" checksum="4C8ADABB371BD5DF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FHD0</accession>
    <name>A0A174FHD0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO49644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49644">
        <property type="protein sequence ID" value="CUO49644"/>
        <property type="gene ID" value="ERS852478_02992"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO49644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="315" mass="36247" checksum="842456DA25A764F3" modified="2016-09-07" version="1">MRDETKMDVYTSGVTGAEYDAGMKQLMSNKEIIVPILQMTVPEFKTCSQEEILQCLDISSITKDDFVSDIPNVEKDLRLTKEDSELSSLVEKLVRFDIRFKIINPKLSTEKIRVNLHIDMEAQKSYRPSNPSYPILKRAVYYVARDLSSQLSTITQTTDYSKLEKCYSIWICAEDVPKKLQNTLTEYSFSKKDIIGVANEPEEDYDLLTVIIIRLGKETEEKGIFDYLKGLFTGDIKRIQRYSHIEWSEPFQEEASKMTGFGDMIYERGIQQGRHEGMILGALMSGKTPEEVSKMLNLPLEEIKKVQEQQMTVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FML6</accession>
    <name>A0A174FML6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201099.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51482">
        <property type="protein sequence ID" value="CUO51482"/>
        <property type="gene ID" value="ERS852478_03045"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7TS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025466">
        <property type="entry name" value="DUF4317"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14199">
        <property type="entry name" value="DUF4317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO51482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="398" mass="45449" checksum="48449ABCB75EB3E9" modified="2016-09-07" version="1">MNKKEISEIKKQFTPENCSLTRICGCYVDGEKNKKTELKEAFLSLSEEEMFKYFEIFRKSLSGTIGKNLMNMEFPLEQETEGGTQHFLMKLRESKLTDDALVESFYDKIIENYDYPENYYIILIHGVYDIPGKSSDGAEMFDASDEIYEHIMCCICPVKLSKAGLCYNAETNSIQDRIRDWIVELPDVAFLFPQFNDRSTDIHGVLYYSKNANELRDIFIDELLGCTAPLSAGGQRDSFNALVEDTLGDDCRYDTVLSIHEKLNDLIESQKDEPEPVVLTKSEVKRLFEECGVEDEKLQSFDEQYEITAGEKSSLVASNITNTKRFEIKTPDVVVHVDPERADLVETRIIDGRKCLVIPMEGEVELNGIRVHTGNENPSDDEFYDNTDTETEETSDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FSM4</accession>
    <name>A0A174FSM4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Putative bifunctional phosphatase/peptidyl-prolyl cis-trans isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_00796</name>
        <name evidence="1" type="ORF">ERS852478_03046</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000020">
        <property type="protein sequence ID" value="VUX63127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379956.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51520">
        <property type="protein sequence ID" value="CUO51520"/>
        <property type="gene ID" value="ERS852478_03046"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO51520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX63127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="266" mass="30340" checksum="5B998CC02C8D7838" modified="2016-09-07" version="1">MENNRKLLFFDIDKTLLTPYPWTVPDSAKQALKEARYNGHLLFINSGRTYTMIPEIIKEMGFDGYVCGCGSQIYMNEELLFSSSIPNPLCRKTTELLRECRIPAFFERPDKILYDSSSCAVPETVQKLKAEVIVEDLALYPPETYNHFTFDKFLAFPSADSDMETFRKFADEHFLCFIHEDKAWELTQKNLSKATGIRFLADRLGVPVKDTYAFGDSTNDLLMLQFAGNSIAMGDSDPLILPHCTYQTTNIEDNGIANALKHFHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FTC1</accession>
    <name>A0A174FTC1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1934 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Uncharacterized beta-barrel protein ywiB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ywiB</name>
        <name evidence="5" type="ORF">BWLFYP14_00782</name>
        <name evidence="1" type="ORF">ERS852478_03059</name>
        <name evidence="2" type="ORF">ERS852523_03130</name>
        <name evidence="4" type="ORF">GT712_15105</name>
        <name evidence="3" type="ORF">GT728_15290</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000040">
        <property type="protein sequence ID" value="CUP88255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000043">
        <property type="protein sequence ID" value="MZL34520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000035">
        <property type="protein sequence ID" value="MZS90360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000020">
        <property type="protein sequence ID" value="VUX63099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993305.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000091_gene2604"/>
    <dbReference type="EnsemblBacteria" id="CUO51869">
        <property type="protein sequence ID" value="CUO51869"/>
        <property type="gene ID" value="ERS852478_03059"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP88255">
        <property type="protein sequence ID" value="CUP88255"/>
        <property type="gene ID" value="ERS852523_03130"/>
    </dbReference>
    <dbReference type="GeneID" id="66493349"/>
    <dbReference type="eggNOG" id="COG4506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015231">
        <property type="entry name" value="DUF1934"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09148">
        <property type="entry name" value="DUF1934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO51869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP88255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX63099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="148" mass="16968" checksum="73F696AB269EB866" modified="2016-09-07" version="1">MDKEVLIHVRGLQTMDADGEQEPLEIVVPGQYYFRNGSHYLRYEEVMEDFAEPTVNYIKISRKGMEVRKKGVVNVHMVFEQGKKNMTYYTTPYGTIEMGIAATNLNLQESDGGLDMKVDYALDMNQEHVADCYLAIKAQPKDCKNFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FTW0</accession>
    <name>A0A174FTW0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacterial mobilisation protein (MobC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO52927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201137.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52927">
        <property type="protein sequence ID" value="CUO52927"/>
        <property type="gene ID" value="ERS852478_03089"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZTUJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008687">
        <property type="entry name" value="MobC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05713">
        <property type="entry name" value="MobC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobC" evidence="1">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO52927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="109" mass="12647" checksum="B43AD6C650095237" modified="2016-09-07" version="1">MNGRKRKVQIKFYVTEEERALIEQKMKLVPTRNMAAYLRKIAIDGYIIQTDHSDIKSMTAEIQKIGVNVNQIAKRVNTTGSVYQEDIEEIKGVLAEIWRLQRLSLLKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FWV4</accession>
    <name>A0A174FWV4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Antirestriction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_03095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201148.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53109">
        <property type="protein sequence ID" value="CUO53109"/>
        <property type="gene ID" value="ERS852478_03095"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009899">
        <property type="entry name" value="ArdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041895">
        <property type="entry name" value="ArdA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041893">
        <property type="entry name" value="ArdA_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013610">
        <property type="entry name" value="ArdC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025465">
        <property type="entry name" value="DUF4316"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040512">
        <property type="entry name" value="LPD15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025923">
        <property type="entry name" value="YodL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07275">
        <property type="entry name" value="ArdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08401">
        <property type="entry name" value="ArdcN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14195">
        <property type="entry name" value="DUF4316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18828">
        <property type="entry name" value="LPD15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14191">
        <property type="entry name" value="YodL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LPD15" evidence="5">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="ArdcN" evidence="3">
        <location>
            <begin position="409"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M78" evidence="2">
        <location>
            <begin position="582"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4316" evidence="4">
        <location>
            <begin position="1183"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO53109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1276" mass="145006" checksum="5C93CB243FDFD3D4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G1Z6</accession>
    <name>A0A174G1Z6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mepA_13</name>
        <name evidence="7" type="synonym">mepA_5</name>
        <name evidence="7" type="ORF">BWLFYP14_00689</name>
        <name evidence="6" type="ORF">ERS852478_03152</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO54859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000015">
        <property type="protein sequence ID" value="VUX62940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201205.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000091.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54859">
        <property type="protein sequence ID" value="CUO54859"/>
        <property type="gene ID" value="ERS852478_03152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
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        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="240"/>
            <end position="262"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="322"/>
            <end position="343"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="385"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="414"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO54859.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VUX62940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="458" mass="49145" checksum="8A7AF2AB998EB12D" modified="2016-09-07" version="1">MNERNNKLELLGSAPIPKALMALGIPIMIGMLINALYNLVDAYFVSGLGKSQMGAISVVFPLGQVVVGLGLMFGNGAASYLSRLLGRGDKDTADKVASTALYSSILIGAIIILLSAIFLKPILVMLGATETIMPYALTYARIYVLSCVFNVFNVTMNNIVSSEGAAKTTMCALLLGAVLNIGLDPLFIYTLDMGVEGAAIATAISQMVSTLVYLTYVLRKKSVFSFSIKEFSPTRQMITEILKIGVPTLVFQLLTSLSIALINRASSNYGDSVIAGMGAVTRVTSMGTLVVFGFLKGFQPIAGFSYGAKKFDRLREAIKTSIIWSTSFCLVVGLVMAVFSMQIISQFTEGDNQMILVGQKSLFANGITFILFGFYTVYSSLFLALGKGAAGFFLGACRQGVCFVPVILLLPMVWGMNGILYAQPIADVISVVITVFMALHLHRESSMAEKQAMSNSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G213</accession>
    <name>A0A174G213_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug export protein mepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_14</name>
        <name evidence="2" type="ORF">ERS852478_03179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55657">
        <property type="protein sequence ID" value="CUO55657"/>
        <property type="gene ID" value="ERS852478_03179"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:antiporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MATE_fam"/>
    </dbReference>
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        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
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            <begin position="196"/>
            <end position="217"/>
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            <end position="340"/>
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            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO55657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="452" mass="49297" checksum="198D1E8BDEC0F55A" modified="2016-09-07" version="1">MARSKEMDLTTGNPFRSLLKFAIPVILGNLFQLFYTLADSVIVGKTLGADSLAAVGSTSIIIYFVFCFINGFTGGFGICLGQKCGAKDEKGMRKSVAVSTLLSIAFTVVLTLTCCLLSHQILRWMQIPADISGEAYDYMFVVLLGTGATVFYNMISNMLRALGDSKTPLYFLVFSSVLNIFLDILFIVPFHMGVAGAAWATILSQFFSAVLSLVVGLKNFPILHLHREDFTDLKDTAILHLKTGFPMGFQMSVMCIGQLAMQAVVNSLGTAAVAGYTAASKADQLSVLVNNAMMTAISNYVAQNFGAGRWDRIRQGVRACLIQTEAFNLIMCIGILLLRHPIVRMFLSDPTKEIYHYSDMYLTIVAPFYFVLGLLAVYRTSIQSMQNGKAPFAACMIELVMRIAATVGLSGIIGYTSVCIASPMAWIGACALLIPVYYKMMKGNCAALLRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GMB4</accession>
    <name>A0A174GMB4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201301.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61585">
        <property type="protein sequence ID" value="CUO61585"/>
        <property type="gene ID" value="ERS852478_03348"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO61585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="257" mass="31260" checksum="0415B2DDF71B5517" modified="2016-09-07" version="1">MQINLLTDGFKDSEKFYQAFLDDTLQQSSFVSDAYVNIPTALPDFPIFFAIRDPKERENEYCKMIKIIAEYVINLDRDIFMDERFWHSWFSLYKREYLLNTYPQIKEDYNTFKNIVIKRFDWENYIYKAILIAQYVEENTLSDKHEYYYRLILRNMDMFNYIIKYEIFRNGQFLINIMDIIAETNLGPVLKAKIKNRPDLGKDERYGRRVIFELNKAYPIVMSPMLDKEMLKEYFLKYLGYYYDGNVEIDKEETLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GPG9</accession>
    <name>A0A174GPG9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cpsD</name>
        <name evidence="11" type="ORF">BWLFYP14_00004</name>
        <name evidence="10" type="ORF">ERS852478_03385</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CpsD/CapB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO62799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000001">
        <property type="protein sequence ID" value="VUX62144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059398.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITF010000157.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62799">
        <property type="protein sequence ID" value="CUO62799"/>
        <property type="gene ID" value="ERS852478_03385"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="AAA_31" evidence="9">
        <location>
            <begin position="47"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO62799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX62144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="236" mass="26463" checksum="A948593D8495BEB2" modified="2016-09-07" version="1">MKKLNLTDKRNPDYFYSEAIKTLRTNIQLSGQSIKTILVTSCYPNEGKSDIVLSLAQELGSIGKKVLLLDADIRKTAYAGRLGVEEEVKGLSQLLSGQVGLQEIIYSTNFPNMDIIFGGPSAPNPSGLLSENIFKVFLKEIREYYNYILIDTPPIGTVIDAAVIGRCCDGAVFLIEPGNVRYRDAQKAFKQLERSGCRILGAVMNKIDTSDDKYYSSYYKHYGEYYHRSDEEAQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZL4</accession>
    <name>A0A174GZL4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycerate dehydrogenase</fullName>
            <ecNumber evidence="7">1.1.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hprA</name>
        <name evidence="7" type="ORF">ERS852478_03495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.29" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060742.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPN010000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66259">
        <property type="protein sequence ID" value="CUO66259"/>
        <property type="gene ID" value="ERS852478_03495"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:glycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05299">
        <property type="entry name" value="CtBP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043322">
        <property type="entry name" value="CtBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="5">
        <location>
            <begin position="24"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="6">
        <location>
            <begin position="108"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO66259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="317" mass="34895" checksum="CA7083CCED4852A9" modified="2016-09-07" version="1">MKVVITDYQYENIDSERSIITGAGYELFDYQVKTTPDLIPVVKDADAVITQYSDINAEVIEHMQNCKIIIKYGIGVNNIDCEAASKKGIYVCNVPDYGVDEVSDHACTMLLALGKKLPILAKSFRKGEWGYSSVVPLLRLSECTLGLVGFGRIPKMVARKMSAFGMKVIAYDPYINETAAQELNVTPVTLEQLLKDSDLISVHCPLTKDTYHLIGKEEMTLLKPNAILVNTARGGIIDEAALIEALQNGKISGAGVDVFENEPVTPEHPLLHMDNVIATPHSAWYSETAIHTLQRKVAEEVVNVLNGNPPFNCVNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZN2</accession>
    <name>A0A174GZN2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201432.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68084">
        <property type="protein sequence ID" value="CUO68084"/>
        <property type="gene ID" value="ERS852478_03558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO68084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="140" mass="16112" checksum="086CF609DAD805D6" modified="2016-09-07" version="1">MRKFNEICKELDDKEAQKLLEKSYDAVVTTRTVFVNKLVESTKKMRENYTLFKTLADLINPENTVEDNTYNFSVIQLAAYIESENLAVERKIASKAVDTFISTLERLEEQSLMTKAEVERIKQIVLDEIKLTVSDLKNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HA51</accession>
    <name>A0A174HA51_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">xerC_2</name>
        <name evidence="6" type="ORF">ERS852478_03625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO70078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008394179.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70078">
        <property type="protein sequence ID" value="CUO70078"/>
        <property type="gene ID" value="ERS852478_03625"/>
    </dbReference>
    <dbReference type="GeneID" id="15232331"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="67"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="190"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO70078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="431" mass="49916" checksum="6A292F9D18E9B889" modified="2016-09-07" version="1">MAKGSVRKKGKKWYYRFYVEDASGNLVQKECVGTESKSETEKLLRQAMDDYEKKKFVAKAENLTVGQLLDVWAEEELKTGTLSNGTVENYLGTIRNIKKHPLAERKLKNVTSEHLQSFFDLLSFGGVHPDGKEKKGYSKDYIHSFSAVMQQSFRFAVFPKQYITFNPMQYIKLRYQTDEVDLFSDEDMDGNIQPISREDYERLLTYLQKKNPAAILPIQIAYYAGLRIGEACGLAWQDVNLEEQCLTIRRSIRYDGSKRKYIIGPTKRKKVRIVDFGDTLVEIFRNARKEQLKNRMQYGELYHTNYYKEVKEKNRVYYEYYCLDRTEEVPADYKEISFVCLRPDGCLELPTTLGTVCRKVAKTLEGFEGFHFHQLRHTYASNLLANGAAPKDVQELLGHSDVSTTMNVYAHSTRDAKRKSVRLLDKVVGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HBQ8</accession>
    <name>A0A174HBQ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Group II intron-encoded protein ltrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ltrA_5</name>
        <name evidence="2" type="ORF">ERS852478_03705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO72274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201496.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72274">
        <property type="protein sequence ID" value="CUO72274"/>
        <property type="gene ID" value="ERS852478_03705"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="261" mass="30284" checksum="3504B49395E74ABD" modified="2016-09-07" version="1">METKLERIAEISANSPGPEFTSLYHLINKEMLLQCHKESDGNKAVGVDEITKKEYGRNLEQNLDDLVERLKRKSYKPQPSIRVYIPKSNGKLRPLGIACYEDKIVQLALKKILEAIYEPRFLNCMYRFRPNRGCHNAIKELCKRLNNTKICYIVDTDIKGFFDHMKHEWIIKFLKLYIKDPNIIGLVKKYLKVGVLDNGELMANEEGSAQGNIISPILANIYMHNVLTLWYKFIITKECKGDNFLIVYADDCAPRRRKLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HFC7</accession>
    <name>A0A174HFC7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_03722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000045">
        <property type="protein sequence ID" value="CUO72971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72971">
        <property type="protein sequence ID" value="CUO72971"/>
        <property type="gene ID" value="ERS852478_03722"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040568">
        <property type="entry name" value="LPD16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041045">
        <property type="entry name" value="LPD25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025923">
        <property type="entry name" value="YodL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18830">
        <property type="entry name" value="LPD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18840">
        <property type="entry name" value="LPD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14191">
        <property type="entry name" value="YodL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LPD16" evidence="2">
        <location>
            <begin position="99"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="LPD25" evidence="3">
        <location>
            <begin position="420"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO72971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="649" mass="75526" checksum="1C45D1A595CB8821" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HIN1</accession>
    <name>A0A174HIN1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5714 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000049">
        <property type="protein sequence ID" value="CUO74764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201528.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000049.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74764">
        <property type="protein sequence ID" value="CUO74764"/>
        <property type="gene ID" value="ERS852478_03784"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043768">
        <property type="entry name" value="DUF5714"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18978">
        <property type="entry name" value="DUF5714"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5714" evidence="1">
        <location>
            <begin position="54"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO74764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="227" mass="25073" checksum="446D36C27F7A3044" modified="2016-09-07" version="1">MKEECIICKAPLIYLEKDEMMECVLCHKKELSKTRCEQGHYVCNECHTKGMDAIIEICLSETSKNPVEIIRRMMAQPFCHMHGPEHHVMVGSALLATYKNAGGEIDLPEALLEMMNRGKAVPGGTCGFWGACGAGISTGMFISIISGATPLKNEPWGLANKMTSKALDAIGSIGGPRCCKRDSYMAIISAIDYVAENFNIQMEKPVIKCIHSDKNNQCIKERCPFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HL39</accession>
    <name>A0A174HL39_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain of resolvase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03746</name>
        <name evidence="4" type="ORF">GT712_18760</name>
        <name evidence="3" type="ORF">GT728_19130</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000046">
        <property type="protein sequence ID" value="CUO73605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000080">
        <property type="protein sequence ID" value="MZL35228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000063">
        <property type="protein sequence ID" value="MZS91023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379881.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73605">
        <property type="protein sequence ID" value="CUO73605"/>
        <property type="gene ID" value="ERS852478_03746"/>
    </dbReference>
    <dbReference type="GeneID" id="66492559"/>
    <dbReference type="eggNOG" id="ENOG50306ZY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006120">
        <property type="entry name" value="Resolvase_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02796">
        <property type="entry name" value="HTH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_7" evidence="1">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO73605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL35228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS91023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="207" mass="24764" checksum="C6BB38526A653416" modified="2016-09-07" version="1">MNFQDQIQQIFGTTDIHELKQISRDADNYRCLNADMNNSIISEKKKNTGRKNSFTEEQLAHILALQDRGEKITDIARQYHVSRQTIYSQIKRAYNFSDDPDVKMRMNFMNHDDLCTTIDIDFRHEKIKIKNYTDQIIFRAFGVVTDPDWADFEYFLEERCFPRTRDHRKDILREMGLPFYDPLLIIEKTQGRMSDDHQWIMILKKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HNC7</accession>
    <name>A0A174HNC7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0178 protein ERS852478_03779</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yaiI</name>
        <name evidence="4" type="ORF">ERS852478_03779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0178 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000049">
        <property type="protein sequence ID" value="CUO74648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201523.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74648">
        <property type="protein sequence ID" value="CUO74648"/>
        <property type="gene ID" value="ERS852478_03779"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00489">
        <property type="entry name" value="UPF0178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003791">
        <property type="entry name" value="UPF0178"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35146">
        <property type="entry name" value="PTHR35146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02639">
        <property type="entry name" value="DUF188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO74648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="151" mass="16922" checksum="ABBE6BC05BCC598E" modified="2016-09-07" version="1">MQILVDADACPVVSIVERVAKEHNLPVTLLCDTNHVLSSDYSEVIVVGAGADAVDYKLISICHKGDIIVSQDYGVAAMVLGKGAYAIHQSGKWYTNENIDQMLMERHLNKKARRASGKNHLKGPRKRTSEDDEHFRESFEKMIHMAMDKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HS04</accession>
    <name>A0A174HS04_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xylose import ATP-binding protein XylG</fullName>
            <ecNumber evidence="5">3.6.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xylG_2</name>
        <name evidence="5" type="ORF">ERS852478_03812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.17" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000052">
        <property type="protein sequence ID" value="CUO75679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201536.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000052.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75679">
        <property type="protein sequence ID" value="CUO75679"/>
        <property type="gene ID" value="ERS852478_03812"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="17"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO75679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="264" mass="29200" checksum="E940442FA62F0372" modified="2016-09-07" version="1">MVVGKTIKNKYPKVRYEKGETLLRFEHITLKNHLNDISFELKRGEVLGIVGLLGAGKTEIAKALFGVYGKGNDKLTGNIWFNGKNARYASPVEAVNAGIGYISEDRGGEGLQVNQAIDFNISLAALKHIRRGVFLDLKKEKAVNQKLIEKLQVKCESMKQKVTNLSGGNQQKVVIAKWFASKARIIVLDEPTRGIDIGAKVEVYKLINEMVEAGIGVILLSSEVPEVFGMADRILVLKDGQITGEYGMDEINKINETDLQRLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HV12</accession>
    <name>A0A174HV12_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000061">
        <property type="protein sequence ID" value="CUO76890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060658.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000061.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76890">
        <property type="protein sequence ID" value="CUO76890"/>
        <property type="gene ID" value="ERS852478_03838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO76890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="157" mass="18464" checksum="C3C1374262483B84" modified="2016-09-07" version="1">MSTTTCKKRKPYKRGARNKTTKTSTLLKDYFNKNNIIFYQRTAEQNIEVFLVPYDIQKQDIKLHIRIIVIDDINLCNMSFSYELNKNTDYSKELLDMNSKLVNGRLSVEKDSNQVTYATNFRLHSNSDVQDIYNQHFESCVSTLASLYKRKIIKTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KN05</accession>
    <name>A0A174KN05_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">prfA</name>
        <name evidence="11" type="ORF">BWLFYP14_01755</name>
        <name evidence="8" type="ORF">ERS852478_00765</name>
        <name evidence="9" type="ORF">ERS852523_00577</name>
        <name evidence="10" type="ORF">GT728_03995</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">2789STDY5834863</strain>
            <strain evidence="9 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP11218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706449.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000036_gene2414"/>
    <dbReference type="EnsemblBacteria" id="CUN67408">
        <property type="protein sequence ID" value="CUN67408"/>
        <property type="gene ID" value="ERS852478_00765"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11218">
        <property type="protein sequence ID" value="CUP11218"/>
        <property type="gene ID" value="ERS852523_00577"/>
    </dbReference>
    <dbReference type="GeneID" id="66493540"/>
    <dbReference type="eggNOG" id="COG0216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="7">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="48"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN67408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP11218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL32379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX64936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="358" mass="40759" checksum="BF1DF4AAD9B1D1EC" modified="2016-09-07" version="1">MFDKLDDLLIRFEEVLNELGEPGVTDNQEHFQKLMKEQSDLQPIVDAYREYKKNKETIQDSLSMLEEEKDEDMREMLKEELSEAKKNVEELEHELKILLLPKDPNDNKNVIVEIRAGAGGDEAALFAAEIYRMYVKYAESRRWKTEMMSLNENGIGGFKEVTFMITGAGAYSRLKYESGVHRVQRVPETESGGRIHTSTCTVAIMPEAEEIDFHLDMNDCKFDVFRASGNGGQCVNTTDSAVRLTHIPTGIVISCQDEKSQLKNKDKALKVLRSRLYEMELAKQHDAEAEARRSQIGTGDRSEKIRTYNFPQGRVTDHRIKLTLHRLENVLNGDLDEIIDSLIAADQAAKLSNLQDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MAX2</accession>
    <name>A0A174MAX2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6 8">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">rplP</name>
        <name evidence="14" type="ORF">BWLFYP14_00262</name>
        <name evidence="10" type="ORF">ERS852478_01664</name>
        <name evidence="11" type="ORF">ERS852523_01288</name>
        <name evidence="13" type="ORF">GT712_08955</name>
        <name evidence="12" type="ORF">GT728_04725</name>
    </gene>
    <organism evidence="11 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">2789STDY5834863</strain>
            <strain evidence="11 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 19">BIOML-A1</strain>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707261.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2977"/>
    <dbReference type="EnsemblBacteria" id="CUO02820">
        <property type="protein sequence ID" value="CUO02820"/>
        <property type="gene ID" value="ERS852478_01664"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33454">
        <property type="protein sequence ID" value="CUP33454"/>
        <property type="gene ID" value="ERS852523_01288"/>
    </dbReference>
    <dbReference type="GeneID" id="66496127"/>
    <dbReference type="eggNOG" id="COG0197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="9">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO02820.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUP33454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL32523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS89196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX67421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="145" mass="16292" checksum="AEAF102DA8D7CB94" modified="2016-09-07" version="1">MLMPKRVKRRKQFRGSMRGKALRGNKINYGEFGLVATEPCWIRSNQIEAARVAMTRYIKRGGQVWIKIFPDKPVTAKPAETRMGSGKGALEYWVAVVKPGRVMFEIAGVSEEIAREALRLAMHKLPCKCKIVSRADLEGGDNSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MBR5</accession>
    <name>A0A174MBR5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_00290</name>
        <name evidence="1" type="ORF">ERS852478_01692</name>
        <name evidence="2" type="ORF">ERS852523_01260</name>
        <name evidence="4" type="ORF">GT712_08810</name>
        <name evidence="3" type="ORF">GT728_04870</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019162473.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03811">
        <property type="protein sequence ID" value="CUO03811"/>
        <property type="gene ID" value="ERS852478_01692"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP32591">
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        <property type="gene ID" value="ERS852523_01260"/>
    </dbReference>
    <dbReference type="GeneID" id="66496156"/>
    <dbReference type="eggNOG" id="ENOG5033JRI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CUO03811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP32591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX67449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="75" mass="9115" checksum="7993B6924A3DB24F" modified="2016-09-07" version="1">MKEYELIWEIFNKCPRNQMRDVFVEELELEDPEEYIRNKFKGKEVSYEKTVLEDGTIIFDITTSQIKQRCSFTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174Q632</accession>
    <name>A0A174Q632_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Rhomboid protease GluP</fullName>
            <ecNumber evidence="8 9">3.4.21.105</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gluP</name>
        <name evidence="9" type="ORF">BWLFYP14_01268</name>
        <name evidence="7" type="ORF">ERS852478_00886</name>
        <name evidence="8" type="ORF">ERS852523_02459</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
            <strain evidence="8 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="8 9"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000026">
        <property type="protein sequence ID" value="CUP68924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993258.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000023_gene1780"/>
    <dbReference type="EnsemblBacteria" id="CUN72172">
        <property type="protein sequence ID" value="CUN72172"/>
        <property type="gene ID" value="ERS852478_00886"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP68924">
        <property type="protein sequence ID" value="CUP68924"/>
        <property type="gene ID" value="ERS852523_02459"/>
    </dbReference>
    <dbReference type="GeneID" id="66493012"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="49"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN72172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP68924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX64169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
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    <sequence length="196" mass="21078" checksum="232C285B1879CD9B" modified="2016-09-07" version="1">MEELKKAPVTVLLILANILVFTAVEFTGGSEDTMHMLQCGAAYTPAIMQGEYYRIFTSMFLHFGPQHLGNNMLVLFVLGGRLERTVGKLKYLLIYLLGGMGGNLLCLFLELDSADFAVSAGASGAVFAVMGAMIYAVIRGRGHIEDLSARQVVIMAAFSLYFGFTSEGVDNAAHVGGLICGFLLAVLLYHPSQRAG</sequence>
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                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
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                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
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                <person name="Venkatesh S."/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="65" mass="7513" checksum="2AA3A140D8897DC7" modified="2016-09-07" version="1">MDKEKEIKAYLDGELLPEVRMKYEIAEEMGLLDRVLSDGWKSLSAKETGRIGGLMTKRKKEKLKK</sequence>
</entry>
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    <accession>A0A174S7J2</accession>
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                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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        <source>
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    <sequence length="352" mass="38221" checksum="8F14AF225D7A3A22" modified="2016-09-07" version="1">MKKKIVSALLTATMVCGMSVVPAVGVAAADDTITVGFSQVGAESDWRTANTESMKSTFSEENGYELIFDDAQQKQENQLTAIRNFIQQEVDYILLAPVTETGWDTVLQEAKDADIPVIIVDRMVDVSDDSLYTTWIGTDSLLEGRKAAEWLNAYTTAKGIDAKDVNIVDIQGTIGSTAQIGRSKGLEEGVDNYGWNLLAQQSGEFTQAKGQEVMESMLKQYDNINVVYCENDNEAFGAIDAIEAAGKTVGSDIANGEIMVMSFDTTNAGLTDTLAGKIACDVECNPLHGPRAEELIKALEAGEEVEKLNYVDEEIFATDDTVDKVKAVNSLDEEGEYDVTPITQEIIDGRAY</sequence>
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<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="4 10 11" key="2">
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                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CUO71411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000066">
        <property type="protein sequence ID" value="CUQ06604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000084">
        <property type="protein sequence ID" value="MZL35280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000010">
        <property type="protein sequence ID" value="MZS88794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580193.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000084.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000067_gene3467"/>
    <dbReference type="EnsemblBacteria" id="CUO71411">
        <property type="protein sequence ID" value="CUO71411"/>
        <property type="gene ID" value="ERS852478_03668"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ06604">
        <property type="protein sequence ID" value="CUQ06604"/>
        <property type="gene ID" value="ERS852523_03824"/>
    </dbReference>
    <dbReference type="GeneID" id="67481366"/>
    <dbReference type="eggNOG" id="COG4200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022294">
        <property type="entry name" value="ABC-transptr_permeasesu"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03733">
        <property type="entry name" value="lanti_perm_MutG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="163"/>
            <end position="186"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ06604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL35280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX63767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="247" mass="27130" checksum="FE1B7CC894902192" modified="2016-09-07" version="1">MVSVVRCWKAEYQKCKHSILLYMHSMIPIICAAIFAGYYHISRWELATKISAYLEVLAVAFPFLIGIIVGLVVQIENQAGHYQLLLGTIPSRMATYIGKLGFLMICAFGATFLALGTFAALYRDAPASLYLKAGILLLITMLPIYLIHLFVGMSFGKGASMGLGIAGSLIAALMITGLGDATWKYIPWAWGVRAMDYTVLAWDSPQLYAQVKTDFFSGMIISVCCTVCLLIASLVWFHGWEGGKNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WV51</accession>
    <name>A0A173WV51_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heavy-metal-associated domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Zinc/cadmium/mercury/lead-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00069</name>
        <name evidence="3" type="ORF">GT728_03095</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="MZL32206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN42806">
        <property type="protein sequence ID" value="CUN42806"/>
        <property type="gene ID" value="ERS852478_00069"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN42806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="72" mass="8214" checksum="8FE90FDF6507668A" modified="2016-09-07" version="1">MKKTYKIDVDCANCANKMEEATRNTAGVKDATVNFMMLKMIVEFEDGQDPKAVMKDVLKNCKKVEDDCEIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X062</accession>
    <name>A0A173X062_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Photosystem II S4 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059754.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43955">
        <property type="protein sequence ID" value="CUN43955"/>
        <property type="gene ID" value="ERS852478_00109"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR002942">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF01479">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17774">
        <property type="entry name" value="YlmH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="1">
        <location>
            <begin position="174"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN43955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="250" mass="28622" checksum="A6008CB4F581F23A" modified="2016-09-07" version="1">MEKDEFFLKRIRELANLSWQRDIVTFSDFLNLNEQNIVSSLKHQFPQIVMETSGGYENAERQMVAFHPDALAFTWEYPIDCLRIEPKALKFSEELSHRDYLGALLNLGVDRSVIGDIVVQKKAAWFFCQNKMTEFFLENLCRVRHTNILITKVEDSDEFPRPVLESVSGTCASVRLDSLISLAFKTSRSSMVSYIEGGQVFVNGKLITSNGYEPKDGDIISVRGKGRFIFDGISHQTKKGRCSVRIMRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X229</accession>
    <name>A0A173X229_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Staphylococcal virulence regulator protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_1</name>
        <name evidence="3" type="synonym">mepA_15</name>
        <name evidence="3" type="ORF">BWLFYP14_02655</name>
        <name evidence="2" type="ORF">ERS852478_00157</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45196">
        <property type="protein sequence ID" value="CUN45196"/>
        <property type="gene ID" value="ERS852478_00157"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN45196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="448" mass="49030" checksum="2756584921E42AA9" modified="2016-09-07" version="1">MKQNKYEIDMCNGTIMDKLISFSLPLMLSGILQLMFNAVDIIVVGRFSGSQALAAVGSTTALINVFTNLFIGISLGANVLAARFYAAGKDREMSDTVHTAVTLALVSGIVMAFVGLIFSRWALELMGTPDDVIGQSALYMKIYFLGMPFFMLYNYGAAILRAVGDTKRPLIFLVISGVVNAVLNLILVIMFHMDVAGVAIATVISQLISCILVLRCLRTSKTSYQLHFGKLRINTVYLKQIFQVGIPAGIQSTVINLSNALLQSSVNSFGSTAMAGYTAANNIFGFLYVAVNSVTQACMSFTSQNYGVHKFKRMDKVLVDCLIISVVTSFSLGCGAYFFGSEILKIYTADPEVIRCGLEILSYTTVPYFLCGIMDLFPGALRGMGHSGVPMILSVIGTVGTRIVWIFGIFPHHRSLAVLFISYPASWMLTIIMQVTCFYFVRRKVHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XCF6</accession>
    <name>A0A173XCF6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN48990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199530.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN48990">
        <property type="protein sequence ID" value="CUN48990"/>
        <property type="gene ID" value="ERS852478_00255"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN48990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="76" mass="9023" checksum="2A1F51BC4E674486" modified="2016-09-07" version="1">MDCKNRIIKLRESTGLNRKDFCKLVHIPYRTMTEWELDNRHAPDYVLWLLEYYIRNEGLMVKGMNEGGGDSEKETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XD03</accession>
    <name>A0A173XD03_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">regX3_1</name>
        <name evidence="11" type="ORF">ERS852478_00247</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN48757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199522.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN48757">
        <property type="protein sequence ID" value="CUN48757"/>
        <property type="gene ID" value="ERS852478_00247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN48757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="225" mass="25297" checksum="6548AAF4BD4B29EB" modified="2016-09-07" version="1">MEQLLIIEDDIGLNQGLSKALKADDRQIISCQDLKTAKEQLLCGGVSLILLDINLPDGSGLELLQEVKENLPGVPVILLTANDTDLDIVDGLERGADDYITKPFSLSVLRARVNTQLRKQASNHKNAPFHMDLFHFDFEAMTFYVGDSKVELSKTEQKLLRLLVENRGRTMTRGDLVDRIWTDGAEYVDENALSVTIKRLRDKLGAQKYIKTVYGIGYSWVTKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XE92</accession>
    <name>A0A173XE92_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Rhamnulokinase</fullName>
            <ecNumber evidence="1">2.7.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rhaB_1</name>
        <name evidence="1" type="ORF">ERS852478_00293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.5" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50101">
        <property type="protein sequence ID" value="CUN50101"/>
        <property type="gene ID" value="ERS852478_00293"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008993">
        <property type="term" value="F:rhamnulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN50101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="101" mass="11328" checksum="AEF4A36808B064BD" modified="2016-09-07" version="1">MAAYYLAVDIGASSGRHILGHMENGKMVLEEIYRFENGMIKKDGELCWEFDRLFKEVVNAGPGEAAAIGNITAQMLKAEEFKTIEEARTIIHESFGVKVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XGT3</accession>
    <name>A0A173XGT3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltose-binding periplasmic proteins/domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199539.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49588">
        <property type="protein sequence ID" value="CUN49588"/>
        <property type="gene ID" value="ERS852478_00275"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015407" evidence="1">
        <location>
            <begin position="32"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN49588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="616" mass="69492" checksum="F5CE70D7FD25E0D8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XHX3</accession>
    <name>A0A173XHX3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sucrose phosphorylase</fullName>
            <ecNumber evidence="2">2.4.1.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.7" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199564.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50910">
        <property type="protein sequence ID" value="CUN50910"/>
        <property type="gene ID" value="ERS852478_00318"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009018">
        <property type="term" value="F:sucrose phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="43"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN50910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="566" mass="65810" checksum="5BDB1F71972D7E53" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XII6</accession>
    <name>A0A173XII6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribose import ATP-binding protein RbsA</fullName>
            <ecNumber evidence="6">3.6.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rbsA_1</name>
        <name evidence="6" type="ORF">ERS852478_00297</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.17" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577582.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50238">
        <property type="protein sequence ID" value="CUN50238"/>
        <property type="gene ID" value="ERS852478_00297"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="240"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN50238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="504" mass="55593" checksum="BDEB28DF4D39D77B" modified="2016-09-07" version="1">MSEYVLELKGITKIFPGVKALNNVQFQLKPGEVHALMGENGAGKSTFIKVITGVHKAEEGEMYLFGEKVDFKGPKDAQAAGIAAVYQHPTSYPHLSVAENIFMGHEIIKHKMIQWKAMNEEANKLLKQLNADFDATAEMGTLSVAQQQMVEIAKALSTHAKIVILDEPTASLTRRESEELYRIVDQLREEGVSIIFISHRFEDMYRLASRVTVFRDSQYIGTYDVDGITNADLIKAMVGREIKDLFPKPEVEIGEEMLRIEGLSRTGYYKNVSFNVHAGEIVGLTGLVGAGRTEVVESVCGITRPDEGKVYLEGQEIHIKQPSDAMEKGIILLPEDRQKEGLIMSWGLGRNVTLPTISKYAKNGLNDEKTERDLAKKLLEEVDTKAVDIFQPASSLSGGNQQKVVVAKALSQEMKVVIMDEPTKGVDVGAKAEIYAIMGDLAKKGYAIILISSEMPEILGMSDRIIVMCNGRKTGELDKEEATQERILELAMEKSQNAGEGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y6Q5</accession>
    <name>A0A173Y6Q5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199701.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58836">
        <property type="protein sequence ID" value="CUN58836"/>
        <property type="gene ID" value="ERS852478_00545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN58836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="141" mass="16325" checksum="AA2E1EB278FC7880" modified="2016-09-07" version="1">MNNTKKNIYIVLLIISIISNMILLYKKISIKNYYKESYLVLQDGKQINIYSIDNSKKQRLKKIDNIQAMVGIVTKLEGKNNNFAVIFNEQRKCDYSVNLNQNNKVSINDKLIVFYSEESSKLISPKSFIVQYGYVILAKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YGM0</accession>
    <name>A0A173YGM0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type taurine transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN62397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199733.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPB010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN62397">
        <property type="protein sequence ID" value="CUN62397"/>
        <property type="gene ID" value="ERS852478_00651"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016161" evidence="1">
        <location>
            <begin position="27"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="49"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN62397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="336" mass="36957" checksum="CC68797FF357A812" modified="2016-09-07" version="1">MKNKKWISLATAVVLAVTALPLGVFAAKKDEAKLAKVTLNEVAHSIFYAPQYVAIEEGYFKDEGLDMTLITGFGADKTMTAVISGEADIGFMGAEASIYAYQEGATDPVVNFAQLTQRAGNFLVAREEMPDFKWEDLKGRKVLGGRKGGMPEMVFEYILKQNGLDPQKDLSIDQSIDFGATAAAFTGDDSADFTVEFEPSATALEKQGAGYVVASLGVDSGYVPYTSYSAKTSYMEKNPDIMQKFTDALQKGMDYVQSHTPEEIAEVIEPQFPETDLDTITAIVKRYYDQDTWKENLVFGQDGFELLQDILEDAGELKERTPYAELVNTEFAQNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YNK9</accession>
    <name>A0A173YNK9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional repressor AcrR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199776.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65741">
        <property type="protein sequence ID" value="CUN65741"/>
        <property type="gene ID" value="ERS852478_00724"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN65741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="215" mass="25321" checksum="9D4D53B1E299C263" modified="2016-09-07" version="1">MSEKTRKQDRRTRYTRQTIKDTFLELLKQKSFTKITVTEICKNAEINRGTFYLHYYDIHDVLSDIFNDMTQDMLTTVDHLFCLNQKSCSYPFCQKIQMESQYRALFLDDAIAPILLEKIAENTKEGYVTWLMSHSLLTFEQAESVFYFQMNGCLSINRLMLRNHCNDWKQIQTVIDKFIKSGLESFLIHDQREENASDNFCNKISPTVTASSTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YP18</accession>
    <name>A0A173YP18_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative HTH-type transcriptional regulator ywnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ywnA_2</name>
        <name evidence="1" type="ORF">ERS852478_00726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199778.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65882">
        <property type="protein sequence ID" value="CUN65882"/>
        <property type="gene ID" value="ERS852478_00726"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN65882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="149" mass="16595" checksum="41B0317A75A6EA9A" modified="2016-09-07" version="1">MKYSTKLSDTVHVMVLIAINQEKSLSSASIAESVHTNPSFVRQLMLKLKKAGLMTSVAGHAHPSLSKPADQITLLDIYKAVEGEKPLLHLDTHTNPDCGVGINIQLSLQGFYNEIQKNAEEKMNTITLQDIINTYYQRTSMQNDLQNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YWT1</accession>
    <name>A0A173YWT1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Recombinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Recombinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_01725</name>
        <name evidence="4" type="ORF">ERS852478_00796</name>
        <name evidence="5" type="ORF">GT728_12545</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000030">
        <property type="protein sequence ID" value="MZL34007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199804.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68444">
        <property type="protein sequence ID" value="CUN68444"/>
        <property type="gene ID" value="ERS852478_00796"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="13"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="178"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN68444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL34007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX64875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="557" mass="64930" checksum="E46E79214CBEA609" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z1G9</accession>
    <name>A0A173Z1G9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Riboflavin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ribU</name>
        <name evidence="9" type="ORF">ERS852478_00829</name>
        <name evidence="11" type="ORF">GT712_14290</name>
        <name evidence="10" type="ORF">GT728_07150</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">BIOML-A1</strain>
            <strain evidence="11 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000013">
        <property type="protein sequence ID" value="MZL32982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000031">
        <property type="protein sequence ID" value="MZS90206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058216.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69580">
        <property type="protein sequence ID" value="CUN69580"/>
        <property type="gene ID" value="ERS852478_00829"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032217">
        <property type="term" value="F:riboflavin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025720">
        <property type="entry name" value="RibU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38438">
        <property type="entry name" value="PTHR38438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037778">
        <property type="entry name" value="UCP037778_transp_RibU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN69580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL32982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS90206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="211" mass="22746" checksum="9C82741DAA851C5C" modified="2016-09-07" version="1">MSEQVLRNGNAMARSKTRTVTQIAMLGAIAGILMNLEFPLPFLAPTFYQLDFSEIPVLVGSFAMGPIAGVLIELVKILVHLVTKGSMTAGVGDVANFIFGCTFAVPAGLIYRYKSVKSRKHAVIGMAVGTVLTAVVACFINAFVLLPAYGKAFGMPVEAFIEMGSAVHSSVNNLLTFAAMIIFPFNIFKYALTSLIVFLIYKRIRVVLKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z807</accession>
    <name>A0A173Z807_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="10">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">murG</name>
        <name evidence="17" type="ORF">BWLFYP14_01264</name>
        <name evidence="13" type="ORF">ERS852478_00882</name>
        <name evidence="14" type="ORF">ERS852523_02463</name>
        <name evidence="16" type="ORF">GT712_08100</name>
        <name evidence="15" type="ORF">GT728_01145</name>
    </gene>
    <organism evidence="13 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 18">2789STDY5834863</strain>
            <strain evidence="14 19">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="15 21 22" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 22">BIOML-A1</strain>
            <strain evidence="16 21">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="17 20" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000026">
        <property type="protein sequence ID" value="CUP68989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS89031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706972.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000023_gene1784"/>
    <dbReference type="EnsemblBacteria" id="CUN72027">
        <property type="protein sequence ID" value="CUN72027"/>
        <property type="gene ID" value="ERS852478_00882"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP68989">
        <property type="protein sequence ID" value="CUP68989"/>
        <property type="gene ID" value="ERS852523_02463"/>
    </dbReference>
    <dbReference type="GeneID" id="66493008"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0133">Cell shape</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_28" evidence="11">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_tran_28_C" evidence="12">
        <location>
            <begin position="187"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetyl-alpha-D-glucosamine binding" evidence="10">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN72027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUP68989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL31837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZS89031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VUX64161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="356" mass="39299" checksum="40E4CC8A16A04BD2" modified="2016-09-07" version="1">MKHIVLTGGGTAGHVTPNIALIPRLKELGYEISYIGSYDGIEKKLIEEMNIPYYGISSGKLRRYFDLKNFTDPFRVLKGFGEAKKLLKQLKPDVVFSKGGFVTVPVVIAAGRRKIPTIIHESDMTPGLANKICIPSATKVCCNFPETVKSLPADKAVLTGTPIRQELLNGSKEAAREFCGFTDDKPVLMVIGGSLGAASVNENIRKILPELLKEFQVIHLCGKGKMDESLKDTKGYVQYEYIKQELADLFALSDIVISRAGANAICELNALKKPNLLIPLSANASRGDQILNARSFERQGFSMVLEEEEITESTLLNAIRELYQNRESYVHAMSESSHMNSIEKITGLIEDCVNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZFS7</accession>
    <name>A0A173ZFS7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Group II intron-encoded protein ltrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ltrA_1</name>
        <name evidence="2" type="ORF">ERS852478_00968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199856.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74613">
        <property type="protein sequence ID" value="CUN74613"/>
        <property type="gene ID" value="ERS852478_00968"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN74613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="429" mass="50188" checksum="4A8B5622D5459F8C" modified="2016-09-07" version="1">MQTNNSKEKVRQLQNKLYLTAKKCDSRRFHALYDKVYRDDVLFEAWKRVKANKGSSGVDGIKIEDVEAMGIEKYLSEIKSELMNGKYKPSPVKRVMIPKPDGSERPLGIPTIKDRIVQMATKIAIEPVFEADFRECSYGFRPKRSAKQALEVVRKACNNKGYYVVDADIEKFFDNVNQEKLMKLVEQRISDRRILKLIKQWLVSGVLYGNVLTISELGTSQGSVISPLLANIYLNTLDRLWEKYGLTHGILVRYADDTVIICKNKKSANHALNLLQYIMAKLDLKLHPVKTKIISMWDGKEGFDFLGMHHRRMTTETRKGQLYKETYQYPSRKAMKKMKAEVKRNVNRRSLLVAKEEDLIKNLNPKITGWKNYYSTKRNEKWMQALDWYIICTFTRWYNKKHQRRNRMSKVGFVRNSIYEKGLKKMARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZYB3</accession>
    <name>A0A173ZYB3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80225">
        <property type="protein sequence ID" value="CUN80225"/>
        <property type="gene ID" value="ERS852478_01102"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z86R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043774">
        <property type="entry name" value="DUF5717_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043775">
        <property type="entry name" value="DUF5717_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18983">
        <property type="entry name" value="DUF5717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18984">
        <property type="entry name" value="DUF5717_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5717_N" evidence="2">
        <location>
            <begin position="1"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5717" evidence="1">
        <location>
            <begin position="868"/>
            <end position="1173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN80225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1195" mass="140666" checksum="2CEAEC70C46BE0E4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A0Y9</accession>
    <name>A0A174A0Y9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein AG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01158</name>
        <name evidence="3" type="ORF">ERS852523_00479</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP07778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2144"/>
    <dbReference type="EnsemblBacteria" id="CUN82164">
        <property type="protein sequence ID" value="CUN82164"/>
        <property type="gene ID" value="ERS852478_01158"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07778">
        <property type="protein sequence ID" value="CUP07778"/>
        <property type="gene ID" value="ERS852523_00479"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50330Z5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014250839" evidence="1">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN82164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP07778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="116" mass="12765" checksum="412DF47722EB2077" modified="2016-09-07" version="1">MLIGVLLAVAAMPVSSKQQKKNTAGEQSEDMQKSVLEEKLEAFLENTEGVGKVQVILMTDEKKDRQSFYNSETIQVTGVLISAEGGGNPVVVQNIQEAVMALFQVDAHRIRIMKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A2T8</accession>
    <name>A0A174A2T8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="5">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroF_2</name>
        <name evidence="7" type="ORF">ERS852478_01180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199947.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82921">
        <property type="protein sequence ID" value="CUN82921"/>
        <property type="gene ID" value="ERS852478_01180"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0722">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DHAP_synth_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PTHR21225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="6">
        <location>
            <begin position="34"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN82921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="343" mass="38884" checksum="34791E818840E768" modified="2016-09-07" version="1">MGFDFIKKLPTPEEIRNQYPIDAEIQAVKDARDKELRDVFTGKSDKFLAIIGPCSADNEDAVLDYLTRLRNVQEKIADKVLIVPRVYTNKPRTTGEGYKGMVHQPDPEKQPNLLAGLVAIRKMHIHAIRTSGMTCADEMLYPENYRYLSDLLSYVAVGARSVEDQQHRLTVSGMEVPAGMKNPTSGDFAVMLNSVVAAQGGHRFIYRSWEVETTGNELAHTILRGAVNKHGEAIPNYHYEDLRLLWEKYQEKNLKNPAVIVDTNHSNSNKQYDQQVRIAKEVLHSRQIDPELHTLVKGLMIESYIEPGNQKIGCDHIYGKSITDPCLGWEESERLLYTIAEMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A410</accession>
    <name>A0A174A410_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptide chain release factor 3</fullName>
            <shortName evidence="6">RF-3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">prfC</name>
        <name evidence="8" type="ORF">ERS852478_01160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199943.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82245">
        <property type="protein sequence ID" value="CUN82245"/>
        <property type="gene ID" value="ERS852478_01160"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04169">
        <property type="entry name" value="RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00072">
        <property type="entry name" value="Rel_fac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004548">
        <property type="entry name" value="PrfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032090">
        <property type="entry name" value="RF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038467">
        <property type="entry name" value="RF3_dom_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041732">
        <property type="entry name" value="RF3_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556">
        <property type="entry name" value="PTHR43556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16658">
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    </dbReference>
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        <property type="entry name" value="prfC"/>
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    </dbReference>
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        <property type="entry name" value="small_GTP"/>
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        <property type="entry name" value="G_TR_1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="9"/>
            <end position="278"/>
        </location>
    </feature>
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        <location>
            <begin position="18"/>
            <end position="25"/>
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        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
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        <location>
            <begin position="86"/>
            <end position="90"/>
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        <ligand>
            <name>GTP</name>
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            <begin position="140"/>
            <end position="143"/>
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            <name>GTP</name>
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        </ligand>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUN82245.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="529" mass="59647" checksum="D8431E6964535F96" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A599</accession>
    <name>A0A174A599_9FIRM</name>
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        <submittedName>
            <fullName evidence="8">Sporulation protein ykvU</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="primary">ykvU</name>
        <name evidence="8" type="ORF">ERS852478_01181</name>
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        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CUN82950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
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        </location>
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            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
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        <location>
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            <end position="344"/>
        </location>
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        </location>
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            <begin position="360"/>
            <end position="433"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
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        </source>
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            <dbReference type="EMBL" id="CUN82950.1"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="438" mass="48380" checksum="5379C27CAE64277D" modified="2016-09-07" version="1">MSKKLFIKGTLLLTFAGLLSRLMGFFYRIFLSHTIGAHGLGIFQLILPLQILIMSICASGIQTAISRLTAAEKVSKNPSRHISDYFVVGTVFSVVFSLVFSWFLYSYADFWAVQILKESQTSGLIRILSLSIPLSTLHTCISSYYLGRKQAGFPAGVQLLEQLFRTGGCYILYLICASQGRNITPAIAVGGNLIGEIASSFISLFAVSMHFKVTHYNIRNIRRPLSVLRKLLHISVPLTMNKILLTLLGSIEVILIPARLQMSGLTPKDSLSVYGIFTGMALPLILFPATLTNSAAAMLIPSITQLQTLGYQKRIQYVIGRIFRYCLLLGGSCLVFFLFLGEFLGNFLFHSQTAGIYIHTMSYICPFLYLNTTLTSVLNGLGKSGLCLLHSVISVCIRISFVLFAIPVLGIRGYLYGILCSELVLSILHSLQILQKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AH66</accession>
    <name>A0A174AH66_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Periplasmic beta-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bglX</name>
        <name evidence="5" type="ORF">ERS852478_01291</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88051.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUN88051"/>
        <property type="gene ID" value="ERS852478_01291"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
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        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="617"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN88051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="706" mass="78208" checksum="0B411FDA0C06E193" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AIA4</accession>
    <name>A0A174AIA4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">23S rRNA (Uracil-C(5))-methyltransferase RlmCD</fullName>
            <ecNumber evidence="7">2.1.1.189</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rlmCD_3</name>
        <name evidence="7" type="ORF">ERS852478_01273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.189" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87400">
        <property type="protein sequence ID" value="CUN87400"/>
        <property type="gene ID" value="ERS852478_01273"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="2"/>
            <end position="60"/>
        </location>
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        <location>
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        </location>
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        <location>
            <position position="284"/>
        </location>
        <ligand>
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        <ligand>
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        <ligand>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUN87400.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
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    <sequence length="558" mass="63163" checksum="E06C90F85A161FA0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AWJ8</accession>
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        <name evidence="2" type="ORF">ERS852478_01402</name>
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            <strain evidence="2 3">2789STDY5834863</strain>
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        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="248" mass="28387" checksum="78EB675B423F8FFC" modified="2016-09-07" version="1">MWADLMAAMACTLANAVDKSLPRHTAREKEYAECIKRLGGVEKPAKCFAIVVEALERNPDQDFLGKLYMSLELGNHWKGQFFTPYNVCECMAGITINDNIQTLEKQEWISVNDPACGAGATLVATANIFRRKKINYQTRVLFTANDIDRVVAQMCYIQLSLLGCAGWVAVANTISNPVCGDPLMPDEKPGQEFWYTPFYFREEWCRRRQLKIFREQFGALVVPLRKIEAERTTFYFDFEKGEYKCQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AXR4</accession>
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            <strain evidence="1 2">2789STDY5834863</strain>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
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        </recommendedName>
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        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_008704624.1">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="90"/>
        </location>
    </feature>
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        <location>
            <begin position="156"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN93751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="217" mass="24597" checksum="C1EB596D2A1D22B6" modified="2016-09-07" version="1">MKVTIKKLSVLKHPEKNVRIHSEQQIRELKRSLEKFGQTRALVIDENNIILIGNGLYEAMVSLGYQEATVYVKAGLSENDKKKLMIADNKTYALGIDNLETLNEFLEELQGDLDIPGYDEEILQQMVADADEVTEKLSEYGTLDDSEIQKIKEANEKREQKAAVDTQSADNGESSPEKPNPQNEQPAEEQNATETEPEITETRRFVVCPKCGERIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B473</accession>
    <name>A0A174B473_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94408">
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        <property type="gene ID" value="ERS852478_01449"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010090">
        <property type="entry name" value="Phage_tape_meas"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1506"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="732"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1513"/>
            <end position="1530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN94408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1582" mass="165474" checksum="1ACDF6DE5F2B65FB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B5K9</accession>
    <name>A0A174B5K9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200110.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95036">
        <property type="protein sequence ID" value="CUN95036"/>
        <property type="gene ID" value="ERS852478_01467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN95036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="63" mass="7185" checksum="D5925786204355A7" modified="2016-09-07" version="1">MMRLLSNFIILLQNDGGKEMMAMLWAQQIMLGKKTYAEVPRLLKAKVKEILEDSGMGELAKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B7Q6</accession>
    <name>A0A174B7Q6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Multidrug export protein MepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_8</name>
        <name evidence="3" type="synonym">mepA_6</name>
        <name evidence="3" type="ORF">BWLFYP14_00956</name>
        <name evidence="2" type="ORF">ERS852478_01521</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96992">
        <property type="protein sequence ID" value="CUN96992"/>
        <property type="gene ID" value="ERS852478_01521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN96992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX63470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="463" mass="50582" checksum="74D49FB76CC62B80" modified="2016-09-07" version="1">MAAYEKSKSVKLKSISTMTEGTIWRQILLFSIPLILGNLLQQMYNTVDSIIVGNFVGSNALAAVGSSTSLICLLIAFSMGASAGAGVIVSQFYGAGDENGVQRSAHTALMLALILGIVLTIAGIVFSPAILRWMRTPEEVMNQSVLYLRIYSYGLVFNVIYNMAAGILNAVGNSRRSLMYLAVASFSNIFLDLWLIGGMHMGVEGAAIATDISQVLSCIFALWFLMRVPDIYRINPKKLSIDRTMAGRIIQVGLPTAIQNTVISFSNVLVQSGVNGFGASAMAGFGAYLKVDGFNILPVMSFSMAATTFTGQNYGAGKTDRIRKGLRVTLGMSVLYTIVTGILLLTFSRPIIGIFSSDKEVIYYGAQAMKYFCPFYFLLGIMHSLAGTIRGTGKTVPPMVVMLLALCLFRILWIQFVVPHFTSIDIIYVLYPVSWAVGMVLMLIYAWKGNWMPKKYQNINQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BA88</accession>
    <name>A0A174BA88_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5348 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003819042.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97099">
        <property type="protein sequence ID" value="CUN97099"/>
        <property type="gene ID" value="ERS852478_01524"/>
    </dbReference>
    <dbReference type="GeneID" id="62695841"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035255">
        <property type="entry name" value="DUF5348"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17295">
        <property type="entry name" value="DUF5348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5348" evidence="1">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN97099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="70" mass="8154" checksum="AC520E84ADAC8997" modified="2016-09-07" version="1">MKQGALIFDEQTDRYDIRFDLADYYGGLHCGETFDVMVGGRWRPTRIEMAENWYLVGIHADDLSGLRVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BEM3</accession>
    <name>A0A174BEM3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">macB_4</name>
        <name evidence="5" type="ORF">ERS852478_01565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99461">
        <property type="protein sequence ID" value="CUN99461"/>
        <property type="gene ID" value="ERS852478_01565"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN99461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="238" mass="26311" checksum="6942248045223124" modified="2016-09-07" version="1">MSEMTDAYVKLDKVSKIYGTKEVKIVAVDEISFEIAKGEFVVIVGPSGAGKTTVLNILGGMDQATSGEVLVDGRNIARYNSRQLTGYRRNDIGFVFQFYNLVPNLTALENVELALQICKNPLDAREVLEEVGLKDRLTNFPAQLSGGEQQRVSIARALAKNPKLLLCDEPTGALDYQTGKAILKLLQDMCRNRGMTVIVITHNSALTPMADRVIKIKNGKVSRMTMNDHPTPIEEIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BGH8</accession>
    <name>A0A174BGH8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF3801)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057305.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00141">
        <property type="protein sequence ID" value="CUO00141"/>
        <property type="gene ID" value="ERS852478_01587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024234">
        <property type="entry name" value="DUF3801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12687">
        <property type="entry name" value="DUF3801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO00141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="163" mass="19010" checksum="5977E68F637E3998" modified="2016-09-07" version="1">MQEEVTQKTVTFCIRATKITADLLKKVLVAYLRHQKQKSVEKKAQKNQPKQGKVTVKELAKQNAGMVNIEITNKNIKSFERYARKYGINYALKKDKSKEPPVYLVFFKGRDQDALNAAFREFSQKQIQKANKPSIHKRLAAYRAMMPKKTKDKVKNRHQEQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BI28</accession>
    <name>A0A174BI28_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugal transfer protein traG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">traG</name>
        <name evidence="3" type="ORF">ERS852478_01588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VirD4/TraG family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057306.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00173">
        <property type="protein sequence ID" value="CUO00173"/>
        <property type="gene ID" value="ERS852478_01588"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003688">
        <property type="entry name" value="TraG/VirD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02534">
        <property type="entry name" value="T4SS-DNA_transf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO00173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="628" mass="71497" checksum="77D812997978340C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BUI4</accession>
    <name>A0A174BUI4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmid recombination enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmid mobilization pre family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO04811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO04811">
        <property type="protein sequence ID" value="CUO04811"/>
        <property type="gene ID" value="ERS852478_01701"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001668">
        <property type="entry name" value="Mob_Pre"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01076">
        <property type="entry name" value="Mob_Pre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="220"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="318"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO04811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="386" mass="45108" checksum="628C66560DB3D449" modified="2016-09-07" version="1">MQRTISAMVGKGSVNHNSRKFRAENVDGTRTHLNIDYCNENIKTVYHELFDEALERYNAKQIRSDRKIKDYYEKIRSSKQEKPFHEIILQVGGKGNMNADTENGELAKQILDEYYQGFQERNPQLRVFSAHLHMDEATPHLHIDFVPFTTGSKRGLDTRVSLKQALATQGFKGGSRGDTEWSQWIQSEKEQLAAVMERYGIEWEHLGTHEKHLSVLDYKKQEREKEVAALGAKIEQKQIEFDVLSERVLNYDKAKDELSNLEIELDTAPKYQLPEPEKFMTAKAYKTKMAEPVVRKLKQLVKTVLARCFEGWDNYHRLNTANAQLYRTNQRLEKVNERLTEENKILKAENKDYSLLRKVFGRKQIDDLLEQARTVKGRKRDNTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BXH5</accession>
    <name>A0A174BXH5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Citrate lyase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200191.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05802">
        <property type="protein sequence ID" value="CUO05802"/>
        <property type="gene ID" value="ERS852478_01730"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039480">
        <property type="entry name" value="C-C_Bond_Lyase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15617">
        <property type="entry name" value="C-C_Bond_Lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO05802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="320" mass="36931" checksum="3ADC03AB83221987" modified="2016-09-07" version="1">MKNNVLYYSVGPLLYCPANRISITDSLINERFGNRFSLALCLEDTINDDHVEEAEQILISSLSQIFIQHEQKPFYLPKIFIRVRNPQQIQRLTKALGQSIKIVTGFIVPKFSPDNAQSYIEQMILVNELVAKKLYMMPIYESPSIIDLRNRIDILYLLRDSLARIEDLILNIRVGGNDLCHMFEFRRHANESIHSIRPVSDIFSDIITVYGMDYVISGPVWEYYAGDGWKEGMIQEIREDRLCGFIGKTVIHPSQIPVVNRAYQVSRNDYLDARAILNWNADSASLVAGSKTRERMNEYKTHLNWAKKTVYLSEVFGITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C096</accession>
    <name>A0A174C096_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TelA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TelA-like protein SA1238</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Toxic anion resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BWLFYP14_01164</name>
        <name evidence="4" type="ORF">ERS852478_01728</name>
        <name evidence="5" type="ORF">ERS852523_02346</name>
        <name evidence="7" type="ORF">GT712_12215</name>
        <name evidence="6" type="ORF">GT728_09985</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">2789STDY5834863</strain>
            <strain evidence="5 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 13">BIOML-A1</strain>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TelA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000024">
        <property type="protein sequence ID" value="CUP65641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000020">
        <property type="protein sequence ID" value="MZL33517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993224.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000018_gene47"/>
    <dbReference type="EnsemblBacteria" id="CUO05749">
        <property type="protein sequence ID" value="CUO05749"/>
        <property type="gene ID" value="ERS852478_01728"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP65641">
        <property type="protein sequence ID" value="CUP65641"/>
        <property type="gene ID" value="ERS852523_02346"/>
    </dbReference>
    <dbReference type="GeneID" id="66492346"/>
    <dbReference type="eggNOG" id="COG3853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008863">
        <property type="entry name" value="Toxic_anion-R_TelA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38432">
        <property type="entry name" value="PTHR38432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05816">
        <property type="entry name" value="TelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026508">
        <property type="entry name" value="TelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR026508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO05749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP65641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL33517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS89817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX63805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="384" mass="43751" checksum="BCB4B2FD6A2E08A3" modified="2016-09-07" version="1">MGLDFGKSSMGNPAQAGNGLQEKNEIEVVEKYDIVADRQQMNAELVNSKEVDDIVSTIEVYNMDTIVSFGAKAAEEISKASDVVLNSMNMSQLNETSEMLKSLAKIMDQFDINEIKDNPGLFGKLFGNFRKQLDKILAKYHTMGEEVDKIYVQLKGYESEIKQSNKKLDTMFKTNVDYYHELVKYILAGEQACKEIEAYIAQRQQDMENTGDQSIQFELTSLNQALMMLEQRTQDLRTAENVAMQSIPMIKTMEFSNYNLVRKINSAFIVTLPVFKQALAQAILLKRQKIQAESIAELDKKTNEMLLKNAQNTVDVSKMTAKMASGSSIQIETLEKTWATITNGIEETRRIQEDARKKRQEDQVRLEAIKQDFNKQYNVPPVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C4M1</accession>
    <name>A0A174C4M1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol-3-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tagD_1</name>
        <name evidence="4" type="ORF">BWLFYP14_01189</name>
        <name evidence="3" type="ORF">ERS852478_01777</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.39" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055054128.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07229">
        <property type="protein sequence ID" value="CUO07229"/>
        <property type="gene ID" value="ERS852478_01777"/>
    </dbReference>
    <dbReference type="GeneID" id="66493421"/>
    <dbReference type="eggNOG" id="COG0615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047348">
        <property type="term" value="F:glycerol-3-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="155"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO07229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX63830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="435" mass="50308" checksum="E1E0693481E8AB47" modified="2016-09-07" version="1">MKRVITYGTFDLFHKGHYNIIKRAKALGDYLIVGVTSESFDIERGKLNVRDSLIKRIENVRRTGLADEIIIEEYQGQKVNDIIKYDIDVLVVGSDWRGKFDYLKNYCDVVYLERTKNISSTKLRSEGVIFNMGIVTDDIRDNDFVEESKYVSGVHVERVFSEDHETAQRFCDKYELGSCWNSYDEFLADVDIVYIKTSLNRRAEYIERALKKGKYVISDSPMTLSSEKLRYLFQVARENNVVLIERTTLVYLRAFNQLVWLVHSNLVGDLVSVKCAISQDDFEGGRTFNETVCTAICAVLKLLGKKCQDINTNAVRNQEGRFVYDMISMKYAGALATIEIGTTVDIENELVIIGSNGRVTIPNDWWNTGYFEANISGKEFLKRYSFNFEGNGFRYLLQELMIMIRDKRTECTRLFYDESVRIIEILETINRKDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C590</accession>
    <name>A0A174C590_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">rplA</name>
        <name evidence="10" type="ORF">ERS852478_01767</name>
        <name evidence="11" type="ORF">GT712_12080</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200248.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06938">
        <property type="protein sequence ID" value="CUO06938"/>
        <property type="gene ID" value="ERS852478_01767"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO06938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS89791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="230" mass="24768" checksum="C395ED1B60166A3D" modified="2016-09-07" version="1">MKRGKKYVEAAKAVDRATLYDTAEAISLVKKAAVAKFDETIEVHIRTGCDGRHADQQIRGAVVLPHGTGKKVRVLVFAKDAKAEEAKAAGAEFVGAEDLIPKIQNEGWLDFDVVVATPDMMGVVGRLGRVLGPKGLMPNPKAGTVTMDVTKAVHDIKAGKIEYRLDKTNIIHVPVGKASFTEEQLSDNFQTLIDAIVKARPSTLKGQYLKSVVITPTMGPGVKINPMKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C9M7</accession>
    <name>A0A174C9M7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="8">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfp_1</name>
        <name evidence="8" type="synonym">pfp</name>
        <name evidence="10" type="ORF">ERS852478_01818</name>
        <name evidence="11" type="ORF">GT728_18330</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000069">
        <property type="protein sequence ID" value="MZL35082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200301.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000069.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08580">
        <property type="protein sequence ID" value="CUO08580"/>
        <property type="gene ID" value="ERS852478_01818"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01978">
        <property type="entry name" value="Phosphofructokinase_II_B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011404">
        <property type="entry name" value="PPi-PFK_XF0274"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036483">
        <property type="entry name" value="PFK_XF0274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="9">
        <location>
            <begin position="5"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="178"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="8">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO08580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL35082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="388" mass="42493" checksum="D95985359F43D699" modified="2016-09-07" version="1">MSQNVLVVHGGGPTAVINASLYGVIEEAKRNPEVGKVYGAIGGTGAIFSETFIDLTSFDDEKLKLLLHTPASAIGSSRYPLYEKDYEKMVDIFKKHDIKYVLLNGGNGTMDACGHIYEVCKDQDIKVVGIPKTIDNDIAMTDHSPGYGSAARFIAASTQEVGEDVKSLPIHVCIMEAMGRNAGWITAASALARRKQGDAPHLIYLPERNFNEDEFLEDVSRLQKKQGGVVVLVSEGLHDANGESIVPPIFKSERAVYYGDVSSHLANLVVKKLGVKARSEKPGLCGRASVALQSPVDREEARQAGTVALRSAVEGNSGVMVGFERVPGTVYQMKTKLVPIKEVMLYERKMPDNFINERGNDVTQEFVDWCRPLIGDPLPEFLNFKDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CD44</accession>
    <name>A0A174CD44_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11431">
        <property type="protein sequence ID" value="CUO11431"/>
        <property type="gene ID" value="ERS852478_01888"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO11431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="45" mass="5377" checksum="CD6B2B7E4A6E4BDD" modified="2016-09-07" version="1">MEAVQRIRLIRIIEKMEKNPEFCNKFGIKNTSEYIAEKESKKGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CDN3</accession>
    <name>A0A174CDN3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11641">
        <property type="protein sequence ID" value="CUO11641"/>
        <property type="gene ID" value="ERS852478_01895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO11641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="431" mass="47815" checksum="32671DB07ACA202E" modified="2016-09-07" version="1">MMMVLILEELREKRKKLKRSTDVALHNMHSIADESIRVAEVAHNSHQILEDLDAEFESQSGLKGNDIKFLFAAVGLQLARIVIVNELTKTEAAGSQNRNETKLHEFQEKLLKRFNTGGPVHERPYYASMEHIITKAGVPYDATAGLTDGALAGLLKKCRTWDFDISNMIPDEKLFLFKGANHRFATLGHDPILGLIFGTGNIMTNTITCVKTPAFLSGIPVLTTNHVVYTSDFKDPRIATYGSTAVMLQQAAERTKDQPGAFIASLIKQLIHIGTDFYTPCGIQIPGANLILSNTQVEKLTGYISSGDIFKVGTSAKLADLINLLISTLHMLMYDPSMNVSRNLYSARTRKIVLYSNMIATGSNVIWVGSNMYAGNEDAIRQLDIGGLIVTVQRLINDTEYIRRIKEEFVFGGFNKKIQGSGLELEDISWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CFY3</accession>
    <name>A0A174CFY3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11159">
        <property type="protein sequence ID" value="CUO11159"/>
        <property type="gene ID" value="ERS852478_01878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO11159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="113" mass="12363" checksum="171E5081D25FA40A" modified="2016-09-07" version="1">MVSFGCKEDVSWLFTFSGTGNSKYIAERIAGSLQEKLICMNERIKSGDTGSVKTGENLVVVVPTYAWRIPHVVSDWIGQTEFVGAKNVCYVMSCGSGIGGADIYDRKLSEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CUP3</accession>
    <name>A0A174CUP3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neu5Ac permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">siaT_1</name>
        <name evidence="4" type="ORF">ERS852478_01993</name>
        <name evidence="5" type="ORF">ERS852523_00090</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
            <strain evidence="5 7">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO96531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2255"/>
    <dbReference type="EnsemblBacteria" id="CUO15538">
        <property type="protein sequence ID" value="CUO15538"/>
        <property type="gene ID" value="ERS852478_01993"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96531">
        <property type="protein sequence ID" value="CUO96531"/>
        <property type="gene ID" value="ERS852523_00090"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011853">
        <property type="entry name" value="TRAP_DctM-Dct_fused"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02123">
        <property type="entry name" value="TRAP_fused"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="622"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="3">
        <location>
            <begin position="147"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO15538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO96531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="655" mass="69921" checksum="8823A0D58CEC3B90" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D124</accession>
    <name>A0A174D124_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cdsA</name>
        <name evidence="14" type="ORF">ERS852478_02063</name>
        <name evidence="15" type="ORF">GT728_13820</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="12"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000035">
        <property type="protein sequence ID" value="MZL34251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707654.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17740">
        <property type="protein sequence ID" value="CUO17740"/>
        <property type="gene ID" value="ERS852478_02063"/>
    </dbReference>
    <dbReference type="GeneID" id="66493737"/>
    <dbReference type="eggNOG" id="COG0575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO17740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL34251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="264" mass="28582" checksum="C07A3DD98A78D556" modified="2016-09-07" version="1">MFKTRLLSGILLVIIALATIISGDYVLFFTLLAVSLIGMRELYRAMKVQDEKINLLAAAGYLGAVLYYLAVLLDFERYGVLAIIFGLVLLMFVYVFTYPTYEAGQVMPALFGIVYVAVMLSFIYLTRELPGGKFHVWLIFLCSWGCDTCAYCVGMLIGKHKMAPVLSPKKSVEGAVGGVAGAALLGVIYAAATQGPMLEYAVICAIGALISMVGDLAASAIKRNQGIKDYGKLIPGHGGILDRFDSVIFTAPVIYFLSLVMIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D2S2</accession>
    <name>A0A174D2S2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fic/DOC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19834">
        <property type="protein sequence ID" value="CUO19834"/>
        <property type="gene ID" value="ERS852478_02109"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="3">
        <location>
            <begin position="108"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="201"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO19834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="348" mass="39702" checksum="9553BE805491D8D5" modified="2016-09-07" version="1">MRNFDYITNPAKLLTPEIVQMVGSIHEHKGKQELFLEANIDELKTLLEVALIQSTGASNRIEGIFTSDKRLEELVSQKAEPRNRSEQEIAGYREVLATIHESYEYITPRPNIILQLHRDLYSYSQGNIGGTYKNSDNVIAETDAEGHQKARFIPVPAFQTAEAIDELCARFLEAWEADRIDKLVLIPMFILDFLCIHPFNDGNGRMSRLLTLLLFYKAGYIVGKYVSMEMLIEKTKETYYEALQASSTGWHEGENSYEPFVKYYLGIMLKAYNEFESRVEHLKYHNLSKPDRIKAVIDNKVGKITKKEIMELCPDISKVTVERTLTDLVKSGYIAKVGAGPSTGYVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D594</accession>
    <name>A0A174D594_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglutaminase-like superfamily</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Transglutaminase-like superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02793</name>
        <name evidence="3" type="ORF">ERS852478_02091</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200548.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19235">
        <property type="protein sequence ID" value="CUO19235"/>
        <property type="gene ID" value="ERS852478_02091"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033T84">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033732127" evidence="1">
        <location>
            <begin position="26"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="169"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO19235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="262" mass="29654" checksum="1645C2E5C97726BC" modified="2016-09-07" version="1">MNRKKITALLLSSVMAFTPAMPAMAEQSTIIDYVDGTTDSTVETPDVTPTPLPEKKEGWETVDGVKYYYVNGEKITNKVEKIGKYTYCFDKTGKLVTNKPYYKVNAKTYYKIKKNGQATKLSAVETMAAVRLQKCKGNLKKAFNWSVSLQYAGNVKVSKKTPTEYGLYGFKTGSGDCYVMAATFYWMAKVAGYDAHYVKGYFQKSGGKKGAHAWVEIDQKVNGKKKTYVYDPNFQKEYKLNGYKLTYGAKRTLKYVNYKRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7E2</accession>
    <name>A0A174D7E2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21531">
        <property type="protein sequence ID" value="CUO21531"/>
        <property type="gene ID" value="ERS852478_02164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024760">
        <property type="entry name" value="HTH_dom_conjug_TS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12645">
        <property type="entry name" value="HTH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_16" evidence="1">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO21531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="80" mass="9469" checksum="ADF3C7C775148A63" modified="2016-09-07" version="1">MKQKRSYKKPSFYVISSAMDGDKISIDKILDFYDPYISKSCIRPLYDEYGNVYIAVDMELKGRIREAIMKMILEFDIKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D986</accession>
    <name>A0A174D986_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Domain of uncharacterized function (DUF3784)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200576.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20849">
        <property type="protein sequence ID" value="CUO20849"/>
        <property type="gene ID" value="ERS852478_02142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017259">
        <property type="entry name" value="UCP037672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12650">
        <property type="entry name" value="DUF3784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO20849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="110" mass="12053" checksum="6672E190960F78AD" modified="2016-09-07" version="1">MKLADLATGSDVTVWIVFVIFAVLSIILLSGHGSWFISGYNTASKEEKEKYDEKKLCRTMGLGMSIIAILLLTMGLLENILPAFFVYIASGIILVDVVVIIILGNTICRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DBX2</accession>
    <name>A0A174DBX2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200594.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21376">
        <property type="protein sequence ID" value="CUO21376"/>
        <property type="gene ID" value="ERS852478_02159"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025037">
        <property type="entry name" value="DUF3923"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13061">
        <property type="entry name" value="DUF3923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO21376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="71" mass="8288" checksum="FCCDC2667E3B3E78" modified="2016-09-07" version="1">MVSKSWKTFQIIQFVLFACVSVFLFTRTVDGHGAVQTLEVKLISFAVWGIFYLGVLAIEWLIYFIARRFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DKW5</accession>
    <name>A0A174DKW5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7 10">Ribose transport system permease protein RbsC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rbsC_3</name>
        <name evidence="10" type="ORF">BWLFYP14_01545</name>
        <name evidence="7" type="ORF">ERS852478_02299</name>
        <name evidence="9" type="ORF">GT712_12865</name>
        <name evidence="8" type="ORF">GT728_12170</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">BIOML-A1</strain>
            <strain evidence="9 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000029">
        <property type="protein sequence ID" value="MZL33934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705556.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26211">
        <property type="protein sequence ID" value="CUO26211"/>
        <property type="gene ID" value="ERS852478_02299"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO26211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL33934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX64691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="326" mass="34654" checksum="F0D6C990CCEEDD28" modified="2016-09-07" version="1">MTKKKKSILSDQRFIVLLVIIVLFAIFSFKSREFRQYTTILSMLDFSYYDLLMAIGVTFPLITGGVDLSIGTGMVCYALIAGSLVRNNNLPVVLAMLLCIVLGIIVGAANGVLIGIMNLPPFLATLCTCMITRGAGSLCSATPWPGLTQEGGWFHSIFKITVGTGRSASRYPIGFLWMIILVLVMEYVLNHTKFGRYTIAIGSNKEAAALSGINVKFYHVMVYVVCGLFTGLAAIAYAAVTPTVQPGTGAGLEMDAIGGVFVGGVAATGGYGSVIGTLAGIFVIMLLKTGLPYIGLQANWQQIITGAVLIIAVLIDIMKEKKAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DNA0</accession>
    <name>A0A174DNA0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable ATP-dependent helicase dinG homolog</fullName>
            <ecNumber evidence="7">3.6.4.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dinG</name>
        <name evidence="7" type="ORF">ERS852478_02283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.12" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200675.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25678">
        <property type="protein sequence ID" value="CUO25678"/>
        <property type="gene ID" value="ERS852478_02283"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="182"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO25678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="785" mass="90802" checksum="55123028141B38BE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DS71</accession>
    <name>A0A174DS71_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Staphylococcal virulence regulator protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_10</name>
        <name evidence="3" type="synonym">mepA_16</name>
        <name evidence="3" type="ORF">BWLFYP14_02927</name>
        <name evidence="2" type="ORF">ERS852478_02348</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000072">
        <property type="protein sequence ID" value="VUX66651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059423.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28323">
        <property type="protein sequence ID" value="CUO28323"/>
        <property type="gene ID" value="ERS852478_02348"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO28323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="454" mass="48945" checksum="36220894130AADEA" modified="2016-09-07" version="1">MSKAKTVDLTSGPILKTLAELALPIMISSMLGTAYSIMDMAWIGLLGAKAVAGVGVGGMYVWLSQGLASLSRMGGQVNTAQACGRKDYDQARSYAAGSLQLTALSGILFAAVCVIFIQPLLGFFNLTDAETYTAAKSYTLITCGLILFSYLNLTLTGLSTAQGDSRTPLLANFIGLAGNMILDPLLILGIGPFPRLEVAGAAIATVSSQILVFVVMVLRIRHSRLEPNVLQHLNLLSVFPKEYYKHIFRIGFPTAIQGSIYCFISMILTRMVSGYGAAAIATQRVGGQIESVSWNTADGFASALNAFIAQNYGARKKDRIRKGYSLSFRVLTIWGLFVTAAFVFLPEPIARLFFHEKEALDTAVNYLVIIGFSEVFMSIELMTVGALSGLGRTRLSSTISVILTGSRIPLALILTHAGMGLNGVWWALTISSIVKGIVFTLTFRHISRRLPEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DTX8</accession>
    <name>A0A174DTX8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">smc</name>
        <name evidence="5" type="ORF">ERS852478_02366</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200713.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28904">
        <property type="protein sequence ID" value="CUO28904"/>
        <property type="gene ID" value="ERS852478_02366"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="4">
        <location>
            <begin position="521"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="227"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="325"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="672"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="854"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO28904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1186" mass="136493" checksum="22E60383AECA7F1D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DZ36</accession>
    <name>A0A174DZ36_9FIRM</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cbiT</name>
        <name evidence="8" type="ORF">ERS852478_02428</name>
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        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
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            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
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    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30872">
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        <property type="gene ID" value="ERS852478_02428"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2099">
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
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        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
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        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003723">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF02571">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="355"/>
        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO30872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="683" mass="75524" checksum="862F789C105647FB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E4K7</accession>
    <name>A0A174E4K7_9FIRM</name>
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        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852478_02478</name>
    </gene>
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        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NatK_C"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HisKA"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47384"/>
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    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="143"/>
        </location>
    </feature>
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            <end position="195"/>
        </location>
    </feature>
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        </location>
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            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="416" mass="48233" checksum="90B82DC074395A99" modified="2016-09-07" version="1">MLSVTYFGGKGLLQRFFFRTGYVYAEETERAEELQEYVTQNKLSASDYKMLKKWGTERNIDDFTISRGKWLLFDISYNGKIMYGSREIPNLTWRMYHRISFKDGTADVYIYEGTADKYFNILMVFSVVLGVAVCIGIVVSGMYENVKYIQCLMKEVNIISRGNLQGNVTVQGTDEIAQLASGLEHMRQTLVKKEQIEYDLKSAQEKLVLGMSHDLRTPLTGLMAYLEILKKQQKEGAVTQEYINKAFDRVLQIRDLSEQMFEYFFVNSRHHIELEPAEDIMCAFGDYLSELCALLEYEGFKVNTDRLEWRQISVCINTDFIGRIMNNIISNIEKYGKHENEVCIQLCYGNEEVGISIQNSITRFDSEHQKTGIGLQNISIMMEQMDGRMEVNADDLTYCIVLYFPEKKEYHKISKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E5X0</accession>
    <name>A0A174E5X0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
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            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380897.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33322">
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        <property type="gene ID" value="ERS852478_02502"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020464" evidence="2">
        <location>
            <begin position="27"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO33322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="336" mass="38314" checksum="DE5FC11A4B7ECB63" modified="2016-09-07" version="1">MKKNHNRLWIVISVCLCLCLTSTISAMQMGGFDIDVGNGENSSWQWHEEQQWNQSSWENTWENNRQTGDNTSETPAQNDQTQDNGYQYDSDTGNGTQDNIQQWNGVQQNNTDWNNSSQWNNNSQNNNVQNNNAQNNNVQSNNARNNNSAWNAQPQTDNNMQITSRTDNESAVKISEKPTPTSIPVPTPKPAKNPKPTKTPKSTQPPTPKLSKKKNKKKQNKAKKTEKENKNTGNSKVFQNKENQGDTVEYTHVKDEAVKFHCTQNTDSFHTPRIQIISRGSVQILSFRLNKTECPWHWEGDWIIPDTEDENVKEIELLVISQGGKLIKMNPRIFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E6L5</accession>
    <name>A0A174E6L5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV domain-containing protein SAV1425</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">DegV family EDD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02505</name>
        <name evidence="4" type="ORF">GT712_02330</name>
        <name evidence="3" type="ORF">GT728_13255</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000033">
        <property type="protein sequence ID" value="MZL34143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703701.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33393">
        <property type="protein sequence ID" value="CUO33393"/>
        <property type="gene ID" value="ERS852478_02505"/>
    </dbReference>
    <dbReference type="GeneID" id="66495256"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO33393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS87959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="290" mass="32155" checksum="D067256197A5CE73" modified="2016-09-07" version="1">MGKIAIVTDSNSGITQDQARELGISVIPMPFYINEKLYLEGITLSQEEFYERLKNDEAISTSQPGPADVCGLWNTLLEKYDEVVHIPMSSGLSASCDTAMGLAQEYDGRVHVVDNQRISVTQRQSVLDALTLRDAGRNATQIKQVLEEQKLDSSIYITLETLKYLKKGGRITPAAAAIGTVLNLKPVLQIQGEKLDAYSKTRGKKQAKRVMLKAMQNDWENRFAEYVKRGEMCLQSAYTGNQEEAEEFKKEIAEVFPEIEIVQNPLSLSVACHIGHGAIAVACSRKVVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EAW9</accession>
    <name>A0A174EAW9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">relA_1</name>
        <name evidence="9" type="synonym">relA_2</name>
        <name evidence="8" type="ORF">ERS852478_02519</name>
        <name evidence="9" type="ORF">ERS852523_03684</name>
        <name evidence="11" type="ORF">GT712_02260</name>
        <name evidence="10" type="ORF">GT728_13325</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">2789STDY5834863</strain>
            <strain evidence="9 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">BIOML-A1</strain>
            <strain evidence="11 14">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate</text>
            <dbReference type="Rhea" id="RHEA:22088"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:142410"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000060">
        <property type="protein sequence ID" value="CUQ03222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000033">
        <property type="protein sequence ID" value="MZL34157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703728.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000029_gene640"/>
    <dbReference type="EnsemblBacteria" id="CUO33736">
        <property type="protein sequence ID" value="CUO33736"/>
        <property type="gene ID" value="ERS852478_02519"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ03222">
        <property type="protein sequence ID" value="CUQ03222"/>
        <property type="gene ID" value="ERS852523_03684"/>
    </dbReference>
    <dbReference type="GeneID" id="66495270"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="6">
        <location>
            <begin position="86"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="7">
        <location>
            <begin position="433"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="5">
        <location>
            <begin position="702"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO33736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUQ03222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL34157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS87945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="776" mass="88712" checksum="E29B05C8FF128E77" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EBD0</accession>
    <name>A0A174EBD0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5'-nucleotidase</fullName>
            <ecNumber evidence="1">3.1.3.5</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="2">HAD-IA family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02501</name>
        <name evidence="2" type="ORF">GT712_02350</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.5" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380896.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33300">
        <property type="protein sequence ID" value="CUO33300"/>
        <property type="gene ID" value="ERS852478_02501"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO33300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS87963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="215" mass="24272" checksum="A1BF8A5CDBB02C80" modified="2016-09-07" version="1">MYKVILFDLDGTLTESGEGITKSVQYALERIGKPEPDLEKLKVFIGPPLMEMFMQYAQIDEATAKQAVEIYRERYSVTGIFENAVYPGIENMLAQLEKKGYILAVASSKPEVYVRQILDHFGLTRYFTEIGGSELNGRRTNKTEVIEDVLKRLNMDKHRDQVIMVGDKEHDVYGARKAGLECIAVSFGYGTEEELKQAEPLKIVDSAEGIVDFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EE09</accession>
    <name>A0A174EE09_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35913">
        <property type="protein sequence ID" value="CUO35913"/>
        <property type="gene ID" value="ERS852478_02574"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020647" evidence="2">
        <location>
            <begin position="30"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="LYZ2" evidence="3">
        <location>
            <begin position="149"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO35913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="282" mass="30089" checksum="CB2B189A42A2102C" modified="2016-09-07" version="1">MKKVLGKYFWLLMTITGALMFGAPALVSASEGTASTDTENSAADNAADTPDDDTIAKTTDSAEKNSQETDHSGEGQISKPKYLENAENNGEEIISDEDPTDNTYGYYTIMGGTTVSVDEMCSLYNSQGCTYPSEELSGGGASDIDTFCNIIVEEANAENVRGEVVFAQAMLETGWLSFGGDAGIDQFNFAGLGTTGGGVKGIAFPDVRTGIRAQVQHLKAYASTDSLNQECVDERFDYVARETAPYVEWLGIQENPYGGGWAAGKDYGSKLRKILADLKSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EEA1</accession>
    <name>A0A174EEA1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Na(+)-translocating NADH-quinone reductase subunit F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380769.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36041">
        <property type="protein sequence ID" value="CUO36041"/>
        <property type="gene ID" value="ERS852478_02578"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027980">
        <property type="entry name" value="RACo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040506">
        <property type="entry name" value="RACo_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041414">
        <property type="entry name" value="Raco_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042259">
        <property type="entry name" value="Raco_middle_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14574">
        <property type="entry name" value="RACo_C_ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17650">
        <property type="entry name" value="RACo_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17651">
        <property type="entry name" value="Raco_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO36041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="646" mass="70367" checksum="49067FA38B090136" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EFG8</accession>
    <name>A0A174EFG8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Ribosome biogenesis GTPase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rbgA</name>
        <name evidence="7" type="synonym">ylqF</name>
        <name evidence="8" type="ORF">BWLFYP14_02466</name>
        <name evidence="5" type="ORF">ERS852478_02598</name>
        <name evidence="6" type="ORF">ERS852523_00195</name>
        <name evidence="7" type="ORF">GT712_07365</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
            <strain evidence="6 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000002">
        <property type="protein sequence ID" value="CUO99963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000011">
        <property type="protein sequence ID" value="MZS88889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000050">
        <property type="protein sequence ID" value="VUX66094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994042.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000003_gene1612"/>
    <dbReference type="EnsemblBacteria" id="CUO36564">
        <property type="protein sequence ID" value="CUO36564"/>
        <property type="gene ID" value="ERS852478_02598"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99963">
        <property type="protein sequence ID" value="CUO99963"/>
        <property type="gene ID" value="ERS852523_00195"/>
    </dbReference>
    <dbReference type="GeneID" id="66494115"/>
    <dbReference type="eggNOG" id="COG1161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019991">
        <property type="entry name" value="GTP-bd_ribosome_bgen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016478">
        <property type="entry name" value="GTPase_MTG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006230">
        <property type="entry name" value="MG442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03596">
        <property type="entry name" value="GTPase_YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="4">
        <location>
            <begin position="10"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="58"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="130"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006230-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO36564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO99963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS88889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="281" mass="31997" checksum="72C6ED691455DCA6" modified="2016-09-07" version="1">MNVQWYPGHMTKAKRQMQEDIKLIDLIIELVDARVPLSSRNPDIDELGKNKSRLILLNKSDLADERQNEAWKTYFQAKGFYVVKVDSRNGSGMKAINNVIQEACKEKIERDRRRGIKNRPIRAMVVGIPNVGKSTFINTFAGRACAKTGNKPGVTKGKQWIRLNKGVELLDTPGILWPKFEDQQVGIRLACVGSIKDDILNMEELALWLIDYLRENYKGILAERYQITEEGTSVEVLEAIARARGCLKKQEELDYAKASLILFDDFRSGKMGRITLEWAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EHH3</accession>
    <name>A0A174EHH3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methenyltetrahydrofolate cyclohydrolase</fullName>
            <ecNumber evidence="2">3.5.4.9</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Sugar ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fchA</name>
        <name evidence="6" type="ORF">BWLFYP14_02445</name>
        <name evidence="2" type="ORF">ERS852478_02576</name>
        <name evidence="3" type="ORF">ERS852523_00174</name>
        <name evidence="5" type="ORF">GT712_07260</name>
        <name evidence="4" type="ORF">GT728_02625</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.4.9" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000002">
        <property type="protein sequence ID" value="CUO99400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000011">
        <property type="protein sequence ID" value="MZS88868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000050">
        <property type="protein sequence ID" value="VUX66073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703872.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000003_gene1590"/>
    <dbReference type="EnsemblBacteria" id="CUO35976">
        <property type="protein sequence ID" value="CUO35976"/>
        <property type="gene ID" value="ERS852478_02576"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99400">
        <property type="protein sequence ID" value="CUO99400"/>
        <property type="gene ID" value="ERS852523_00174"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007044">
        <property type="entry name" value="Cyclodeamin/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036178">
        <property type="entry name" value="Formintransfe-cycloase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04961">
        <property type="entry name" value="FTCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101262">
        <property type="entry name" value="SSF101262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FTCD_C" evidence="1">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO35976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO99400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="209" mass="22504" checksum="76C284229F9A4107" modified="2016-09-07" version="1">MGFSTSTCTEFVEVLASKAPVPGGGGASALVGAVGTALGNMVGSLTVGKKKYADVEDEMYELKAKCDQLQKDFLRLIERDAEVFEPLSKAYGMPKETEEEKAEKARVMEIVLKDACSVPMEIMEKCCEAIELIVEFGAKGSKLAISDAGVGAAFCKAALQGASLNVYINTKSMADREYAEELNRKADAMLEKYTKIADDTFNSVLGRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EWU0</accession>
    <name>A0A174EWU0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BMP family ABC transporter substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Purine-binding protein BAB2_0673</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02728</name>
        <name evidence="5" type="ORF">ERS852523_02530</name>
        <name evidence="7" type="ORF">GT712_09815</name>
        <name evidence="6" type="ORF">GT728_09550</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">2789STDY5834863</strain>
            <strain evidence="5 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">BIOML-A1</strain>
            <strain evidence="7 10">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000027">
        <property type="protein sequence ID" value="CUP70676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000019">
        <property type="protein sequence ID" value="MZL33436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000017">
        <property type="protein sequence ID" value="MZS89358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707919.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000058_gene2546"/>
    <dbReference type="EnsemblBacteria" id="CUO40979">
        <property type="protein sequence ID" value="CUO40979"/>
        <property type="gene ID" value="ERS852478_02728"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP70676">
        <property type="protein sequence ID" value="CUP70676"/>
        <property type="gene ID" value="ERS852523_02530"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014251180" evidence="2">
        <location>
            <begin position="24"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="3">
        <location>
            <begin position="47"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO40979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP70676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL33436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS89358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="392" mass="41876" checksum="CCDD2293C187BD22" modified="2016-09-07" version="1">MKKALAIGLAAVMAVSMSAPVFAEDEGKGIAKEDLKVGVIYIGDENEGYTAAHMKGIDEMEEKLGLDDSQIIEKTLIGEDEGCYDAAADLADQGCQIIFANSFGHETYILEAAGEYPEVQFCHATGTQAASSGLSNMHNYFTNIYEARYVSGVVAGLKLNEMIEDGTVKEDACKMGYVGAFPYAEVISGYTAFYLGAKSVCPSVTMEVKYTNSWASFDLEKECADALISDGCVLISQHADTTGAPTACEAAGVPCVGYNIDMTSVAPNTALTSASMDWGVYYTYAVQCMLDGTAIDTDWCKGFAEGADKITALNDKTVAEGTEEKVKEVEDALIDGSLHVFDTSAFTVDGKELDTYKKGDTEYISDGYFHESEYGSAPAFDIAIDGITSITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F0U5</accession>
    <name>A0A174F0U5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacteriophytochrome cph2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cph2_3</name>
        <name evidence="2" type="ORF">ERS852478_02770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42528">
        <property type="protein sequence ID" value="CUO42528"/>
        <property type="gene ID" value="ERS852478_02770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO42528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="259" mass="29861" checksum="668617E9856F6C86" modified="2016-09-07" version="1">MSKKPPLQNLGFKWWEHVTAFFQPKYDMCTDRVIGAEALVRWEHPEKGLLPPGIFIPVLEKNGYIAKVDLYIYEETCIFLKKCMDEGIPLHPVSVNLSRVGFYNPNLFQTLCEIAERYQIPRKYLELEITETAYATDSEMIFSVVEKLRQGGFRILMDDFGSGYSSLNMLKEAPVDEIKLDMRFLSAADPYGRAEEILHMIITMGNHMKLSIIAEGVETEQQKVMLQGFGCNKAQGYFYARPMREAEYTELLKKEKAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F1A8</accession>
    <name>A0A174F1A8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate kinase</fullName>
            <ecNumber evidence="5">2.7.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glxK</name>
        <name evidence="5" type="ORF">ERS852478_02801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.31" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200936.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43337">
        <property type="protein sequence ID" value="CUO43337"/>
        <property type="gene ID" value="ERS852478_02801"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO43337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="373" mass="38810" checksum="6680395244A58738" modified="2016-09-07" version="1">MKVVVVVDSFKGSMTSMEAGMAVKEGILAAKKDAEVVVKPLADGGEGTTDALIEGLKGERVDVTVTGPYYEPVQAYYGYLRESNTAVMEMATAAGITLSDKKDPMTATTCGVGELILHAISRGIRNFIIGIGGSATNDGGVGMLKALGYRFLDEKGEDAGEGGQALARIASVEISDKKELLSQCNFRIACDVTNPLCGSQGATYIYGPQKGVTPDMLPVLDAGMKNYAEVTAKVIGKDNQNAAGAGAAGGLGFAFLNYLDGELTPGIQLILNAVHVEDEMKDADVVVTGEGCLDHQTAMGKAPVGVAKLGKKYGAKTIAFAGSVTKEAVACNEAGIDAFFPIIRGISTLEEAMDLDTAKTNMAATAEQVFRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F638</accession>
    <name>A0A174F638_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Propanediol utilization protein PduB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial microcompartment</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200939.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43625">
        <property type="protein sequence ID" value="CUO43625"/>
        <property type="gene ID" value="ERS852478_02811"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044870">
        <property type="entry name" value="BMC_CP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009193">
        <property type="entry name" value="EutL_PduB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030984">
        <property type="entry name" value="PduB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012290">
        <property type="entry name" value="EutL_PduB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04501">
        <property type="entry name" value="microcomp_PduB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51931">
        <property type="entry name" value="BMC_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC circularly permuted" evidence="3">
        <location>
            <begin position="11"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO43625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="238" mass="24765" checksum="DCF87B4BA078312C" modified="2016-09-07" version="1">MIDIKNISTHCTRSEFVGTAVLDTIGLVISGIDDTLLETMNVGMKYRCLGLFSSRTGAAGQITAIDDAVKATNTEVLSIELPRDTKGWGGHGNYIVLGGTDVSDVRHAISMALELTNKNAGEVYISESGHLEFAYSASAGQVLNKAFGVPMGEAFGFMAGSPAAIGLVMADTAMKSASLSIAKYMTPDKGTSHSNEVILAVAGDASAAKTAVLNARQIGLELLIAMGSYPETPGVPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FB75</accession>
    <name>A0A174FB75_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2116 family Zn-ribbon domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_03420</name>
        <name evidence="2" type="ORF">ERS852478_02887</name>
        <name evidence="3" type="ORF">GT712_19800</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000093">
        <property type="protein sequence ID" value="MZS91208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705137.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000153.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46218">
        <property type="protein sequence ID" value="CUO46218"/>
        <property type="gene ID" value="ERS852478_02887"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019216">
        <property type="entry name" value="DUF2116_Zn-ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09889">
        <property type="entry name" value="DUF2116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO46218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS91208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX67143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="114" mass="12789" checksum="E4625F172AD15FBC" modified="2016-09-07" version="1">MKKCRYCGKELDSNLEFCSSECENSYRKIIEKDRHKIKYFISSIILGFLAMFYGVVSSRNCMIGSGIIVMGVTVVLLPFTTSETTALFGNKKARFIGRILGMILIAVGIWVGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FDS6</accession>
    <name>A0A174FDS6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="5 11">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">hom_2</name>
        <name evidence="15" type="ORF">ERS852478_02964</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 11"/>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201033.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48472">
        <property type="protein sequence ID" value="CUO48472"/>
        <property type="gene ID" value="ERS852478_02964"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0460">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="NAD_binding_3" evidence="14">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine_dh" evidence="13">
        <location>
            <begin position="132"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO48472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="404" mass="44056" checksum="E8B3EA7FE3444D95" modified="2016-09-07" version="1">MINVAILGYGTVGSGVFEVLNENKESISRRAGQELHVKYVLDLRDFPGQPVEKVLVHDYEQIVSDPEVDIVVEVMGGVEPAYTFVKKALLAGKNVCTSNKALVAKHGRELMDIAKEKSINFLFEASCGGGIPIIRVINSSLTGDEIDEVTGILNGTTNYMLYKMSTEGCEFDTVLKEAQQKGYAEADPTADVEGYDACRKIAILSSLAYERYFDFEDIYTEGITKITPEDMAYAAKLGRTIKLLGTSRRLADGTCYAMVAPFMLGQNSPLYSVNDVFNAVFVHGNMLGDAMFYGSGAGKLPTASAVVGDIVDAAKHLHVNIVTNWNSTPAVLKPLDEVTGKFFVRIKKEAAEEAKKVFGDVEIISLGQLPQECAFITDEMTQGAFEEKLAQIGDQVLAKIRVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FEW3</accession>
    <name>A0A174FEW3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTH-type transcriptional repressor glcR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glcR_3</name>
        <name evidence="4" type="ORF">ERS852478_02950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48077">
        <property type="protein sequence ID" value="CUO48077"/>
        <property type="gene ID" value="ERS852478_02950"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO48077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="260" mass="29203" checksum="991812981492C428" modified="2016-09-07" version="1">MDEERGAMFTEERQSAIENCLRENGKVKVKELSEMFQVTEDCIRKDLKTLENAGKLKRTYGGAILSQDYPLKRDVVDRRQFNLDKKRTIAAKAFKLIKNNETIFLDISTTNIELAKLLATSNMRVVVVSNMIDILQILATNPSITAIGTGGTMYQTVNGFMGAATIEVIKQYSFDRAFIGSCGVDMTDCAITTLGVEDGLTKKAAVHSSRHKYVVMERDKFYFNDSYKYAYFDDISGIVTDEFPDDTIVSTLERAGVKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FFU2</accession>
    <name>A0A174FFU2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldehyde-alcohol dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">adhE_3</name>
        <name evidence="5" type="ORF">ERS852478_02981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO49084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201047.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49084">
        <property type="protein sequence ID" value="CUO49084"/>
        <property type="gene ID" value="ERS852478_02981"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08178">
        <property type="entry name" value="AAD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034789">
        <property type="entry name" value="AAD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012079">
        <property type="entry name" value="Bifunc_Ald-ADH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000111">
        <property type="entry name" value="ALDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="3">
        <location>
            <begin position="15"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-ADH" evidence="4">
        <location>
            <begin position="463"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO49084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="885" mass="96834" checksum="46ECFC686741210B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FG21</accession>
    <name>A0A174FG21_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional repressor DicA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_03393</name>
        <name evidence="2" type="ORF">ERS852478_02922</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47075">
        <property type="protein sequence ID" value="CUO47075"/>
        <property type="gene ID" value="ERS852478_02922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO47075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX67116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="204" mass="23911" checksum="0704F1AE248C10A7" modified="2016-09-07" version="1">MQESSISEKIKELRTDLKMNQKNFSAAIGIRQSTLSSYENGVVTPSNDVLLTIAQKFHVSLDWLFGLSENKVQISTLSDILWVLLQMNESNELRYELDINNKLPGDIETETQKWYAGLRFYGNDPEHSLNADMCNFLADLQENRESLESYFTGKDMFDMWKKQTLEYYTSKPVTHKEIEELDFETRIRKRDELLTQKFSNNEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FXC5</accession>
    <name>A0A174FXC5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF3847)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO54087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579837.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54087">
        <property type="protein sequence ID" value="CUO54087"/>
        <property type="gene ID" value="ERS852478_03131"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031UPX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024215">
        <property type="entry name" value="DUF3847"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12958">
        <property type="entry name" value="DUF3847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO54087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="98" mass="11767" checksum="056DBD67D5D3D4E8" modified="2016-09-07" version="1">MPDTSKLEKLNRELEKSEKKLRKAINDEKVLQHQLKQLTRKERTHRLCTRGGMLESFLQEPERLTDDDVMLLLKLIFHRKDTQELLKTMLEREKPETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G1X9</accession>
    <name>A0A174G1X9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">glgB_2</name>
        <name evidence="12" type="ORF">ERS852478_03196</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381049.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56463">
        <property type="protein sequence ID" value="CUO56463"/>
        <property type="gene ID" value="ERS852478_03196"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="6" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="238"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO56463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="766" mass="87028" checksum="67D4E2799F1B2679" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GF57</accession>
    <name>A0A174GF57_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO59560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201266.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59560">
        <property type="protein sequence ID" value="CUO59560"/>
        <property type="gene ID" value="ERS852478_03296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="12"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO59560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="134" mass="15989" checksum="6FAB2DE41592BC50" modified="2016-09-07" version="1">MDYRYNRHNRRKYSLKVHIVLVTKYRKQLLKGSIADDVKQKILDIANTRGYEIIAMETDKDHIHFLLSYDTTDRVCDIVKIVKQETTYYLWQKYNSVLSKQYWKKKIFWSDGYFACSIGEVSSATIQKYIESQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GJM9</accession>
    <name>A0A174GJM9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Capsular polysaccharide type 8 biosynthesis protein cap8A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cap8A</name>
        <name evidence="8" type="ORF">ERS852478_03386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO62822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201392.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62822">
        <property type="protein sequence ID" value="CUO62822"/>
        <property type="gene ID" value="ERS852478_03386"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="7">
        <location>
            <begin position="25"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO62822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="259" mass="28341" checksum="10D05A95047742B4" modified="2016-09-07" version="1">MLDNLNSNFESSKAQRADANDDEVEIDLLEIFYALKKKILLVLMVALAGGCIAAAYTQFLMTPIYSSTSSILVLSKETTLTSLADLQLGASLTSDYTVLITSTPVMEQVISDLNLDMTAEQLKESVSINNPTDTRILEITVNNTDSKMAKKIVDEIANVSSSYIGDKMEVIPPKIIEVGKIATVRTSPSVKKNAALGFLLGFLACAAIVVVYAVMDDTIKTEEDIEKYLGVSVLAKVPDRKDFINSKNRKSKNKNKKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GLV5</accession>
    <name>A0A174GLV5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Toxin A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">toxA_4</name>
        <name evidence="5" type="ORF">ERS852478_03413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63534">
        <property type="protein sequence ID" value="CUO63534"/>
        <property type="gene ID" value="ERS852478_03413"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018337">
        <property type="entry name" value="Cell_wall/Cho-bd_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011105">
        <property type="entry name" value="Cell_wall_hydrolase_SleB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042047">
        <property type="entry name" value="SleB_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01473">
        <property type="entry name" value="Choline_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19127">
        <property type="entry name" value="Choline_bind_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07486">
        <property type="entry name" value="Hydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51170">
        <property type="entry name" value="CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022642" evidence="3">
        <location>
            <begin position="30"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="Cell wall-binding" evidence="2">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_2" evidence="4">
        <location>
            <begin position="327"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO63534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="457" mass="51681" checksum="E62803CB53D6E7BA" modified="2016-09-07" version="1">MKKHGKLLLKYLLLFVMTVFVMGCFSVSAATKTGFVTQKGKTYYINKDGSKQKGWLELKGKKYYFDKKTGVQVKGWVKDSSGQAIRYFTRGAGYMVTGFITDSNGNTRHFDETTGLLTRGWLTDTDEYKYYFYSGSGVMAKGWVENKKEQKRYFSQANGRMCTGWVKSSAGNYRYFKPSNGIMYTGLEKIDSDYYYFSKSTGVRYQKGFGTVGSKKYYFNPSDGKAKTGWLELDGKKYYFDTSGVMLANTIASIDGTTYRFDSDGAATKTSGNDYTVEGKYVKVFDAKNNKYYYMEEEFLEHPGIADGKVSDLDLLAAVCDAEAGDQGVVGMEAVALCVLNCTIDQYKEFPSQIRYVVYQGKPTQYAVVTDGALLKRLKGQFEDRTNAYAAAKAAMEVFSNYVNHGTKRTLPGFKTKDFNYKFFMTPAAFKAQNLNFSKLEYEQYKGHVFFVDWISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GQI5</accession>
    <name>A0A174GQI5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_00067</name>
        <name evidence="2" type="ORF">ERS852478_03453</name>
        <name evidence="3" type="ORF">ERS852523_02905</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO64962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000035">
        <property type="protein sequence ID" value="CUP81603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000045">
        <property type="protein sequence ID" value="VUX65953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64962">
        <property type="protein sequence ID" value="CUO64962"/>
        <property type="gene ID" value="ERS852478_03453"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP81603">
        <property type="protein sequence ID" value="CUP81603"/>
        <property type="gene ID" value="ERS852523_02905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045532">
        <property type="entry name" value="DUF6467"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20071">
        <property type="entry name" value="DUF6467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO64962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP81603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="164" mass="17018" checksum="4FE67825BE177294" modified="2016-09-07" version="1">MVTPVAMEPLLGYHPCSIGFLTSRRDPAVGQCQTGSLTGAVASERVSEAPKGSLRMDGNHSKSAKAEGSLTATPTGGAGTKVGLSDPVVLSGNAIAQRIKATLGITGLSLPRVHIDGVVWHLDVGSSHPGAVVGPKGWAVRPLKRYASWVQNVVRQFGPYPAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GSD5</accession>
    <name>A0A174GSD5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF134 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Nitrogenase cofactor biosynthesis protein NifB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02262</name>
        <name evidence="3" type="ORF">ERS852478_03428</name>
        <name evidence="4" type="ORF">GT728_10880</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0251 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580427.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64078">
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        <property type="gene ID" value="ERS852478_03428"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1342">
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00851">
        <property type="entry name" value="MTH1175"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
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        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
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        <property type="entry name" value="MTH1175_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR37478">
        <property type="entry name" value="PTHR37478"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF134"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53146"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="134"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO64078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="257" mass="27912" checksum="44E34F7523A8A028" modified="2016-09-07" version="1">MPRPIKCRKVCHFPNVLEFLPADDTEKKAPIILTVDEYETIRLLDKKGYSQEQCAVSMQIARTTVQRIYEIARKKIADALIDGHPLRIEGGDFRICDGQSSDCNLGGCYKQELYQKYAVEKGEGIMRIAVTYENGQIFQHFGHTETFKIYDVEEGKVVHSEVVDTNGSGHGALAGVLNALNADVLICGGIGGGAQTALAAAGIKLFGGVSGDADEAVEAFINETLAYNPNVKCSHHEHNHGEGHTCGEHGCVSHSCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GTZ7</accession>
    <name>A0A174GTZ7_9FIRM</name>
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        <submittedName>
            <fullName evidence="2">Helix-turn-helix</fullName>
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        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02282</name>
        <name evidence="2" type="ORF">ERS852478_03448</name>
        <name evidence="3" type="ORF">GT712_16200</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000042">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704385.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000068.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64568">
        <property type="protein sequence ID" value="CUO64568"/>
        <property type="gene ID" value="ERS852478_03448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="41"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO64568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="99" mass="11565" checksum="967A3E31716A1954" modified="2016-09-07" version="1">MQENMKEYLTEKEAKEKRLEVYTEKIQEKVLSRSSETIRQLVEERHRQKMTQQEIADITGIKPSNMARFESGGRVPTLVVLEKYANALGKHIEIKICDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GUZ5</accession>
    <name>A0A174GUZ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bioY_2</name>
        <name evidence="4" type="ORF">ERS852478_03457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65047">
        <property type="protein sequence ID" value="CUO65047"/>
        <property type="gene ID" value="ERS852478_03457"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="BioY"/>
    </dbReference>
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        <property type="entry name" value="PTHR34295"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO65047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="146" mass="16272" checksum="404D8E6C263B0792" modified="2016-09-07" version="1">MISVVAYMLLGLAGLPIFSEGGGIWYIFKPSFGYIIGFCLGTYVTGLIAERLKQKTVFHYLLANLAGLMIVYACGMVYYYVICNYVIDTPIGIWPLILYCFLLAVPGDIALSVLGAVIAKRVRPVVLQYLFDSKSNVRLEREELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZN1</accession>
    <name>A0A174GZN1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lyase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_03468</name>
        <name evidence="2" type="ORF">ERS852478_03496</name>
        <name evidence="3" type="ORF">GT712_19580</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000082">
        <property type="protein sequence ID" value="MZS91170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000081">
        <property type="protein sequence ID" value="VUX67193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704394.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000133.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66290">
        <property type="protein sequence ID" value="CUO66290"/>
        <property type="gene ID" value="ERS852478_03496"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08352">
        <property type="entry name" value="VOC_Bs_YwkD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037478">
        <property type="entry name" value="YwkD-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO66290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS91170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX67193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="127" mass="14841" checksum="612CE92A76B63B00" modified="2016-09-07" version="1">MNLSKIHHIAIIVSDYEVAKDFYVNKLGFSVIRENYRPERKDWKLDLRVNEHTELEIFAEENPPKRANRPEACGLRHLAFCVESVEQTVNELAEVGIECEPIRMDDYTGKKMTFFHDPDGLPLELHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H273</accession>
    <name>A0A174H273_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67149">
        <property type="protein sequence ID" value="CUO67149"/>
        <property type="gene ID" value="ERS852478_03524"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO67149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="204" mass="23277" checksum="BCC1426414789EE5" modified="2016-09-07" version="1">MQNNQSIMQISENKDGSAKVLFRIRKAEMADVDEIMAVMHEAKNDKEHPDWFVSDDEEYVRTHIEEQGFVIVAQTADGSVAGFFLIKYPENREDNLGTYLDFDEEQLSHVAVMDSAVVCCAYRGNGLQGHMLEEAERLLDTDQYYYLMCTIHPDNQFSRHNMEIHGYEVKRTALCYGGLPRCILLKDLTESGKSPAQVVKSSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H5P1</accession>
    <name>A0A174H5P1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO70213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026649178.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000072.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70213">
        <property type="protein sequence ID" value="CUO70213"/>
        <property type="gene ID" value="ERS852478_03632"/>
    </dbReference>
    <dbReference type="GeneID" id="66495481"/>
    <dbReference type="eggNOG" id="ENOG5033ZIT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO70213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="84" mass="9566" checksum="B5BB4548751FBF29" modified="2016-09-07" version="1">MLFDSRTVYLGASRDKYEQYCKALDSEKIKYKTKRVNHEEKMTAPGRGTVRSMGGNFGTDKTLYEIMVGEKDYDNAMGILTALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HBF6</accession>
    <name>A0A174HBF6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Excisionase from transposon Tn916</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_00532</name>
        <name evidence="1" type="ORF">ERS852478_03700</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO72213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000004">
        <property type="protein sequence ID" value="VUX62675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579822.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72213">
        <property type="protein sequence ID" value="CUO72213"/>
        <property type="gene ID" value="ERS852478_03700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032W5T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038148">
        <property type="entry name" value="Tn1545/Tn916_Xis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015122">
        <property type="entry name" value="Tn916-Xis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09035">
        <property type="entry name" value="Tn916-Xis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO72213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX62675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="69" mass="7966" checksum="DD843C7B86CD27AE" modified="2016-09-07" version="1">MNHTEKTIPVWEKYSLNVSEAAEYYGIGEKRLRQIAGENEGADFILEVGSHIRFKRKLFEDYLDTASTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HCV9</accession>
    <name>A0A174HCV9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000044">
        <property type="protein sequence ID" value="CUO72664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201503.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72664">
        <property type="protein sequence ID" value="CUO72664"/>
        <property type="gene ID" value="ERS852478_03714"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="300" mass="33057" checksum="7525E14CD214B246" modified="2016-09-07" version="1">MKTTLLIMAAGIGSRFGTGIKQLEPVDDTDHIIMDYSIHDAIEVGFNHVVFIIRKDIEKEFKDVIGDRIASVCSAHDVTVDYVFQDIKDIPGTLPEGRTKPWGTGQAVLAAKKVIKTPFIVINADDYYGREGFKAVHEYLMNGGKSCMAGFVLSNTLSDNGGVTRGICKMDENGNLTEIVETKNIVKTADGAEAGGVSVDVNSLVSMNMWGLTPGFLDVLENGFKEFFDKEVPSNPLKAEYLLPVFIGELLEQGKMSVKVLKTNDTWYGMTYHEDVASVKDSFRKMQENGVYKADLFSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HD18</accession>
    <name>A0A174HD18_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">strL</name>
        <name evidence="4" type="ORF">ERS852478_03717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000044">
        <property type="protein sequence ID" value="CUO72724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201504.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72724">
        <property type="protein sequence ID" value="CUO72724"/>
        <property type="gene ID" value="ERS852478_03717"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO72724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="304" mass="34033" checksum="FF3AF00837AE3BD3" modified="2016-09-07" version="1">MKFFVTGVGGQLGHDVMNELLKRGHEGVGSDIQENYSGVADDSAVTKAPYIALDITDKDAAEKVITEVNPDAVIHCAAWTAVDMAEDDDKVAKVRAINAGGTQNIADVCKKLNCKMTYISTDYVFDGQGTEPWQPDCKDYKPLNVYGQTKLEGELAVSQTLEKYFIVRIAWVFRLNGKNFIKTMLNVGKTHDTVRVVNDQIGTPTYTYDLARLLVDMNETEKYGYYHATNEGGYISWYDFTKEIYHQAGYKTAVLPVSTEEYGLSKAARPFNSRLDKSKLVEAGFTPLPTWQDALSRYLKEIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HDH9</accession>
    <name>A0A174HDH9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">Int-Tn_11</name>
        <name evidence="1" type="ORF">ERS852478_03720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000045">
        <property type="protein sequence ID" value="CUO72894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72894">
        <property type="protein sequence ID" value="CUO72894"/>
        <property type="gene ID" value="ERS852478_03720"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO72894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="146" mass="16715" checksum="7DF25F156F13383B" modified="2016-09-07" version="1">MISLRKRDIKKALKAGAKAGGVSLADVRADIEATIDEAMDSADPEVQTNFKKYFGNKRPTPEEYIYKTMSDEVYQAFQNILKHRRKQKNLVIDGYSVFLFINRNGNPQVAVNYEAVFRKLVDKYNSKHEEPLPKITPHGRVIIRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HFD1</accession>
    <name>A0A174HFD1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03747</name>
        <name evidence="3" type="ORF">GT712_18765</name>
        <name evidence="2" type="ORF">GT728_19135</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 5 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A1</strain>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000046">
        <property type="protein sequence ID" value="CUO73632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000080">
        <property type="protein sequence ID" value="MZL35229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000063">
        <property type="protein sequence ID" value="MZS91024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379882.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73632">
        <property type="protein sequence ID" value="CUO73632"/>
        <property type="gene ID" value="ERS852478_03747"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0400">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO73632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL35229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS91024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="184" mass="21056" checksum="C165F606046530C4" modified="2016-09-07" version="1">MKAAVFFPGIGYHCDKPLLYYSRKLAQECGYEETIALSYTYDGGNIRGNEEKMQQAFESLYEQAEKSLSAIDFDKYDEILFVAKSVGTIIASAYAEKHSIRCRQILYTPLKYTYNFVHRDAIAFIGTSDPWSIVPEVQALSQKQQVPMYTYKNANHSLETTDTLENLKILQDVMGKTKGFLERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HHW7</accession>
    <name>A0A174HHW7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000045">
        <property type="protein sequence ID" value="CUO72987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72987">
        <property type="protein sequence ID" value="CUO72987"/>
        <property type="gene ID" value="ERS852478_03723"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO72987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="56" mass="6591" checksum="366EF89DA4511E42" modified="2016-09-07" version="1">MITWLPALLRIVGRIINGIMNVNAIKECRLLCDFQMRKVCYSEIKQEANRVRRVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HLD5</accession>
    <name>A0A174HLD5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH dehydrogenase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_03768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZN01000048">
        <property type="protein sequence ID" value="CUO74266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704448.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74266">
        <property type="protein sequence ID" value="CUO74266"/>
        <property type="gene ID" value="ERS852478_03768"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007516">
        <property type="entry name" value="Co_F420_Hydgase/DH_bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007525">
        <property type="entry name" value="FrhB_FdhB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04432">
        <property type="entry name" value="FrhB_FdhB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04422">
        <property type="entry name" value="FrhB_FdhB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO74266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="418" mass="47093" checksum="3A2BF3B494A0D3B9" modified="2016-09-07" version="1">MIEINDKVNCSGCTACYAVCPQSAIEMKLDEEGFKYPRVDKNRCVECGLCNSVCPILNKRKIGEETTSGYIVQNKNDSIRLKSTSGAAINAIAEYVISCGGVVFGCEFSDDRVCRHTMATDISDLGKFQGSKYVQSELGDCFKSIKEQLDADKKVLFIGMPCQVAGLESYIKRNKENLYLIDLACHGVPSPGVFKDFIQFLEHKYKGKISNFVFRDKTYGYSATNIKVYFANGKTIDCRNDIKTFTRLMFKGITLRPSCYECAFKTKHRVSDITIFDCALVGSYNKDMDDDIGTTSILCHSDKGKKLLEQPDVIDKMRIKSVDSEELILTEGSMLIASAKKSENREAFFHDRELMTYEQLTNKYAPITLKMIIGDIVKRSLRYTGPIGKAVILYNKKKSIEKYQREFMGRSGENETAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HMI1</accession>
    <name>A0A174HMI1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide pyruvyl transferase CsaB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000048">
        <property type="protein sequence ID" value="CUO74358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201519.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74358">
        <property type="protein sequence ID" value="CUO74358"/>
        <property type="gene ID" value="ERS852478_03772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="14"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO74358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="388" mass="45166" checksum="F8916F269C8D6F93" modified="2016-09-07" version="1">MIIGLFGFDFISSNKGCEALTYTFLSMMERICDEKKLYVYNFTYNKTLGRIPEQFPEIEFKQCNINLKNLRYWKNAFKLLKTCDVFFDATFGDGFSDIYGKKWNIKTDLIKQMVIWSGTPLVLVPQTYGPYNNLVLKKWAMRLIRKADLVYSRDNLSAKVIKEQSGVEIKVGSDMAFKLPYDRTKYKIDNERINIGINVSSLLWDSQWAKENHFGLTVDYKQYHIKILEWLIEQSKYKIHIIPHVIDLEQPNARENDYRVCLQLKKKYGDKIEIAPPFNTPIEAKSYIANMDVFIGSRMHATIGSISSGVATIPFSYSRKFEGLFGNLEYPYVISARNFSLEEALEKSKSWIQNYEILKGCGQKSVVESYAKLELLENDIRCLLEKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K893</accession>
    <name>A0A174K893_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_03104</name>
        <name evidence="2" type="ORF">ERS852478_01130</name>
        <name evidence="3" type="ORF">ERS852523_00451</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP07051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2171"/>
    <dbReference type="EnsemblBacteria" id="CUN81254">
        <property type="protein sequence ID" value="CUN81254"/>
        <property type="gene ID" value="ERS852478_01130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07051">
        <property type="protein sequence ID" value="CUP07051"/>
        <property type="gene ID" value="ERS852523_00451"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SA4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032111">
        <property type="entry name" value="Clostridium_phage_holin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16079">
        <property type="entry name" value="Phage_holin_5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN81254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP07051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="97" mass="10401" checksum="9E04A18DD74B6FA3" modified="2016-09-07" version="1">MEQITNYVKPELIVVAIALYFVGMALKQAQAVKDKYIPLILGGISIAICAIYVFATCTCGTGQDIAMAIFTAITQGILIAGLSTYVNQIVKQANKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174N3T8</accession>
    <name>A0A174N3T8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative manganese efflux pump MntP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yebN</name>
        <name evidence="8 13" type="synonym">mntP</name>
        <name evidence="13" type="ORF">BWLFYP14_01587</name>
        <name evidence="9" type="ORF">ERS852478_03526</name>
        <name evidence="10" type="ORF">ERS852523_01599</name>
        <name evidence="12" type="ORF">GT712_12655</name>
        <name evidence="11" type="ORF">GT728_12385</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probably functions as a manganese efflux pump.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MntP (TC 9.B.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP43384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000029">
        <property type="protein sequence ID" value="MZL33977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705613.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000119_gene3269"/>
    <dbReference type="EnsemblBacteria" id="CUO67190">
        <property type="protein sequence ID" value="CUO67190"/>
        <property type="gene ID" value="ERS852478_03526"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP43384">
        <property type="protein sequence ID" value="CUP43384"/>
        <property type="gene ID" value="ERS852523_01599"/>
    </dbReference>
    <dbReference type="GeneID" id="66494459"/>
    <dbReference type="eggNOG" id="COG1971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01521">
        <property type="entry name" value="MntP_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003810">
        <property type="entry name" value="Mntp/YtaF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022929">
        <property type="entry name" value="Put_MntP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35529">
        <property type="entry name" value="PTHR35529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02659">
        <property type="entry name" value="Mntp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO67190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP43384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL33977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS89897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX64733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="184" mass="19691" checksum="8857FF513369D737" modified="2016-09-07" version="1">MNIFELFILAIGLSMDAFAVSVCKGLSLGRINAKHMCIAGAWFGGFQALMPLVGYFGGRFFADKVTRYSHWVAFVLLVFIGAGMIKESKEEEHVNADMDIKSMFILAVATSIDALAVGVTFAFLKVEIVSAVSFIGVITFVCSAAGVKIGSLFGMKYKSKAELCGGIILILIGTKILLEGLGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NJ06</accession>
    <name>A0A174NJ06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavin reductase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Flavoredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">flr</name>
        <name evidence="2" type="synonym">flr_1</name>
        <name evidence="5" type="synonym">flr_2</name>
        <name evidence="5" type="ORF">BWLFYP14_02859</name>
        <name evidence="2" type="ORF">ERS852478_02198</name>
        <name evidence="3" type="ORF">ERS852523_01700</name>
        <name evidence="4" type="ORF">GT712_11330</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000015">
        <property type="protein sequence ID" value="CUP46510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707992.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000021_gene1706"/>
    <dbReference type="EnsemblBacteria" id="CUO22607">
        <property type="protein sequence ID" value="CUO22607"/>
        <property type="gene ID" value="ERS852478_02198"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP46510">
        <property type="protein sequence ID" value="CUP46510"/>
        <property type="gene ID" value="ERS852523_01700"/>
    </dbReference>
    <dbReference type="GeneID" id="66493390"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="11"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO22607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP46510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="196" mass="21985" checksum="D09E74E463D0A635" modified="2016-09-07" version="1">MEKETWKAGNMLYPLPAVMVSVSDGEGNDNIITVAWAGTVCTNPPMVSISVRPSRFSYDMLRKTGEFVINLTTEKLAYATDYCGVRSGRDVDKFKEMKLTKEKADFVKVPMIAESPVSIECKVRQVLELGSHHMFLADVLAVHADPQYMDEKKKFHLNDAKPLVYSHGEYLGIGKKLGTFGYSVKKKKKKSGKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174P027</accession>
    <name>A0A174P027_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="8">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pfp_1</name>
        <name evidence="8" type="synonym">pfp</name>
        <name evidence="14" type="synonym">pfp_2</name>
        <name evidence="10" type="synonym">pfp_3</name>
        <name evidence="14" type="ORF">BWLFYP14_02767</name>
        <name evidence="10" type="ORF">ERS852478_03183</name>
        <name evidence="11" type="ORF">ERS852523_01919</name>
        <name evidence="13" type="ORF">GT712_14485</name>
        <name evidence="12" type="ORF">GT728_04450</name>
    </gene>
    <organism evidence="11 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">2789STDY5834863</strain>
            <strain evidence="11 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 19">BIOML-A1</strain>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000018">
        <property type="protein sequence ID" value="CUP53176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000007">
        <property type="protein sequence ID" value="MZL32469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000032">
        <property type="protein sequence ID" value="MZS90244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703460.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000009_gene1470"/>
    <dbReference type="EnsemblBacteria" id="CUO56113">
        <property type="protein sequence ID" value="CUO56113"/>
        <property type="gene ID" value="ERS852478_03183"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP53176">
        <property type="protein sequence ID" value="CUP53176"/>
        <property type="gene ID" value="ERS852523_01919"/>
    </dbReference>
    <dbReference type="GeneID" id="66495750"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01978">
        <property type="entry name" value="Phosphofructokinase_II_B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011404">
        <property type="entry name" value="PPi-PFK_XF0274"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036483">
        <property type="entry name" value="PFK_XF0274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="9">
        <location>
            <begin position="7"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="191"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="8">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="8">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO56113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP53176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL32469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS90244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX66393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="418" mass="45954" checksum="EE7B2465F4A021CD" modified="2016-09-07" version="1">MAKKRNIIVGQSGGPTAVINSSLAGVYKNAIERGFDKVYGMLHGIQGLLDEQYIDLSTQIHSELDIELLKRTPSAFLGSCRYKLPEIHEDKAIYEKIFEILNKLDIYAFIYIGGNDSMDTIKKLSDYAILTGQTQKFLGVPKTIDNDLALTDHTPGFGSAAKYIGASTKEVIRDALGLTYKKNMITIMEIMGRNAGWLTGATALAKSEDCDGPDLIYLPEVPFDVEKFLAKVKDLLNKKASIVIAVSEGIKLADGRYVCELGSVGDYVDAFGHKQLQGTATYLANFLAAECGCKTRAVELSTLQRSASHMASRVDIDEAFMVGGAAVKAADEGDTGKMVVIDRVSDDPYMAATGIYDVHRIANEEKLVPREWMNKDATNVTKDFVDYIKPLIQGDYQPIMVNGMPRHLVLNMKKGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174P6X8</accession>
    <name>A0A174P6X8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 14">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">hemB</name>
        <name evidence="20" type="ORF">BWLFYP14_00130</name>
        <name evidence="16" type="ORF">ERS852478_02407</name>
        <name evidence="17" type="ORF">ERS852523_01992</name>
        <name evidence="19" type="ORF">GT712_04425</name>
        <name evidence="18" type="ORF">GT728_02010</name>
    </gene>
    <organism evidence="17 22">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 21 22" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 21">2789STDY5834863</strain>
            <strain evidence="17 22">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="18 24 25" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 25">BIOML-A1</strain>
            <strain evidence="19 24">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="20 23" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 14"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000019">
        <property type="protein sequence ID" value="CUP55281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL32009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704753.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1134"/>
    <dbReference type="EnsemblBacteria" id="CUO30172">
        <property type="protein sequence ID" value="CUO30172"/>
        <property type="gene ID" value="ERS852478_02407"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP55281">
        <property type="protein sequence ID" value="CUP55281"/>
        <property type="gene ID" value="ERS852523_01992"/>
    </dbReference>
    <dbReference type="GeneID" id="66494294"/>
    <dbReference type="eggNOG" id="COG0113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8 14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="11">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="11">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUO30172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUP55281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MZL32009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MZS88357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VUX66577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="327" mass="36384" checksum="547D6A830045A743" modified="2016-09-07" version="1">MDLIQRPRRLRGSENLRKMVRETRMDKSSLIYPLFVKEGTGIEEEIPSMEGQFRYSVDRLPFELERLQNAGVNSIMLFGIPDHKDEVGSGAYDPNGIVQKALREAKKQFPDMYYITDVCMCEYTSHGHCGVLCGHDVNNDATLELLAKTAVSHVEAGADMVAPSDMMDGRVRAIREALDANGHYGAPIMSYAVKYASAFYGPFRDAAGSAPSFGDRKSYQMDFHNRREGMKEALTDVEEGADIIMVKPAMSYLDMVSEVSKAVNVPVATYSVSGEYAMVKAAAKMGWIDEERIMCEMAVSAYRAGAQIYLTYYAKELAKCMDEGRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174PTX0</accession>
    <name>A0A174PTX0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_00904</name>
        <name evidence="1" type="ORF">ERS852478_02641</name>
        <name evidence="2" type="ORF">ERS852523_02308</name>
        <name evidence="4" type="ORF">GT712_04975</name>
        <name evidence="3" type="ORF">GT728_06975</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
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    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CUO38181">
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        <property type="gene ID" value="ERS852478_02641"/>
    </dbReference>
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    </dbReference>
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    </evidence>
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            <dbReference type="EMBL" id="CUP64423.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZL32948.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZS88457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX63426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="121" mass="14010" checksum="D2230CD2A8D09966" modified="2016-09-07" version="1">MYQDNITLCGASAYEKKFYFNQDFNALPDHVKKELQIMCVLYTEDVGGILTLEFDENGRLQFKTEALEADARYDEIGSGLKIKQLQQDKKELLESLEMYYKVFFLGDIPEEELKKTSGSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174UJ63</accession>
    <name>A0A174UJ63_9FIRM</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00409</name>
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        <name type="scientific">Blautia wexlerae</name>
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            </authorList>
        </citation>
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        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
            <strain evidence="4 6">2789STDY5834911</strain>
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    </reference>
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    </dbReference>
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        <property type="gene ID" value="ERS852478_00409"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ20771">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
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        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN53655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUQ20771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="193" mass="23018" checksum="79227B23F687469E" modified="2016-09-07" version="1">MLLSDRQRLRGEVQKFIEEMHRLKTELSETQKLNQSLQQSNDDLRNRNGLMSRSEQEQIEKEIEDDVIDFFRIPFMWYIRFCEWLVFPTYDNAFKQKIAYTGGRTWIIRILAIIVVFFILAIVTLIITEGIRQYEKMWDEISQMFLVGSLSGISVLGDAIREYLPVNLILLFGFVNTGIMLLKMYFRKKFDYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WU81</accession>
    <name>A0A173WU81_9FIRM</name>
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        <submittedName>
            <fullName evidence="3">47 kDa membrane antigen</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">ERS852478_00077</name>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="CUN43041">
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    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
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    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
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        <property type="entry name" value="PBP-Tp47_A"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF82220"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008014922" evidence="1">
        <location>
            <begin position="29"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="2">
        <location>
            <begin position="474"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="2">
        <location>
            <begin position="554"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN43041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="629" mass="66536" checksum="13EAD3B99B8EF5D0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X2Z4</accession>
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        </submittedName>
        <submittedName>
            <fullName evidence="3">NTP transferase domain-containing protein</fullName>
        </submittedName>
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    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02687</name>
        <name evidence="2" type="ORF">ERS852478_00191</name>
        <name evidence="4" type="ORF">GT712_00505</name>
        <name evidence="3" type="ORF">GT728_06040</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZL32778.1"/>
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    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46073">
        <property type="protein sequence ID" value="CUN46073"/>
        <property type="gene ID" value="ERS852478_00191"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2068">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
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    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN46073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS87608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="228" mass="25735" checksum="EC9E56837E4516C4" modified="2016-09-07" version="1">MKIAMIMLAAGNSRRFGANKLLYEIDGIPMYRHVLEQLDDTKKKIENIYSEYSDITEDNNNDNNSDIVQLNNLYRNNITAKIICNIIVITQYDAIAEAVKTKEIQVLYNPHPEDGISSSVKIGLNASLDADAVLFTVSDQPWLTSETICELIHVFLNTSKGIACVSCQGKMGNPCIFDRKYYNELLSLEGDKGGKKVIMKHLDDTQIYEIEAGRELEDIDYYESIAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X4L7</accession>
    <name>A0A173X4L7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.177</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (pseudouridine1915-N3)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m3Psi1915 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (pseudouridine-N3-)-methyltransferase RlmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">rlmH</name>
        <name evidence="5" type="ORF">BWLFYP14_02668</name>
        <name evidence="2" type="ORF">ERS852478_00170</name>
        <name evidence="3" type="ORF">ERS852523_00327</name>
        <name evidence="4" type="ORF">GT728_06140</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10221"/>
            <dbReference type="Rhea" id="RHEA-COMP:10222"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74486"/>
            <dbReference type="EC" id="2.1.1.177"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase RlmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.177" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000003">
        <property type="protein sequence ID" value="CUP03712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381411.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000032_gene387"/>
    <dbReference type="EnsemblBacteria" id="CUN45525">
        <property type="protein sequence ID" value="CUN45525"/>
        <property type="gene ID" value="ERS852478_00170"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03712">
        <property type="protein sequence ID" value="CUP03712"/>
        <property type="gene ID" value="ERS852523_00327"/>
    </dbReference>
    <dbReference type="GeneID" id="66495853"/>
    <dbReference type="eggNOG" id="COG1576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070038">
        <property type="term" value="F:rRNA (pseudouridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18081">
        <property type="entry name" value="RlmH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00658">
        <property type="entry name" value="23SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003742">
        <property type="entry name" value="RlmH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33603">
        <property type="entry name" value="PTHR33603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02590">
        <property type="entry name" value="SPOUT_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004505">
        <property type="entry name" value="MT_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00246">
        <property type="entry name" value="tRNA_RlmH_YbeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="1">
        <location>
            <begin position="127"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN45525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP03712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="159" mass="18178" checksum="68A41B5E3FC42213" modified="2016-09-07" version="1">MEIRIVTVGKIKEKYLCDGIAEYAKRLSRYCKLTFCQVADEKTPDKASEALNTQIKNTEGERLMKHIREQDYVIALAIDGKTPDSVELSQKIEKLGVSGISSIAFVIGGSLGLSESVLKRADYKLSFSRMTFPHQLMQMILLEQIYRSYRIMNHEPYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X4N0</accession>
    <name>A0A173X4N0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein involved in cytokinesis, contains TGc (Transglutaminase/protease-like) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381207.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46769">
        <property type="protein sequence ID" value="CUN46769"/>
        <property type="gene ID" value="ERS852478_00214"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="159"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN46769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="392" mass="45085" checksum="88DE6F0B060981F3" modified="2016-09-07" version="1">MSKKRFSGLRLILMVPVVVLLAGGLIIGGRALQEPGEVRTLKRQEVAQTDEGHQEYYFGLLNENEQRGYREILEGIRSFEDKFYLSLSGDNEIDRVYHAVLKDHPELFWVHNREKVYKTTYSGRDYCQFSPGYTYTEEQRQEITQAMENAYQEVLSQIPDGADDYTKVMTVYTYVIDNTEYVISDDDQSIAGAFWKKQAVCAGYAGAVQYLLERLDIPCIYVEGDAANSTQGHAWNIVELNGQYYYVDATNGDQPDFLEGDATLLAEHKTTIYDYLCPFPQEYEENYTASDEFPVPACTATDMNFYVRNGACFDTYDWSSVYDLCRLRIDSDAAVVRFKFGSQGAYDEAYMDLIDSNHIQDIAKYYMEVHGLSQISYHYGVIDNMKTLYFMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XDH9</accession>
    <name>A0A173XDH9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized hydrolase YxeP</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yxeP</name>
        <name evidence="2" type="ORF">ERS852478_00279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199542.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIOY010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49704">
        <property type="protein sequence ID" value="CUN49704"/>
        <property type="gene ID" value="ERS852478_00279"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="182"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN49704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="389" mass="43915" checksum="0EDD1AE242BC1856" modified="2016-09-07" version="1">MNIEKYTEELITLRHYFHQHPELALQEVETSAYIRKYLEKLGYEIVPIEPTGLIAELSSLRNREKLVVLRAEMDALPIQEQTNLPYASVNQGCMHACGHDMILAAALILAKIVAEEQRMQENFPVRLRFLFEPAEEIGEGAKRMLQAGALENPKADAFLMFHYAADMTFGMAVHQGQASSMINSMQIHVHGKSSHWCEADKGIDAIYAAAQVISAIHDLNESFGKQHPDAGKYIVGTGTIHGGEYTNIIADHVVLNGNIRAVHEETYMALEHELERNLQEIEKQTGTQIRMEFPKDPVYAFANDEELTETAKAVGEEVFGDKFVLEGEDELFLSGDNAYRYFRETRGLFTVFLAGIPGENHPLHHPKFQLDERILPYSVEALYKIITTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XH76</accession>
    <name>A0A173XH76_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199557.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50366">
        <property type="protein sequence ID" value="CUN50366"/>
        <property type="gene ID" value="ERS852478_00301"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025159">
        <property type="entry name" value="AbiEi_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13338">
        <property type="entry name" value="AbiEi_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN50366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="201" mass="23040" checksum="FAD9246F15F03FC1" modified="2016-09-07" version="1">MSKKEILKTVIENNGGIAKTSDFAANGINKYEVAAFCKEGVIERIRRGFYQLPQSKSITEEQLIRELLPQGIICVESALFHYGYSDFSPREWSIAVPRTASRAVKNIEEFPMKAYYIQKDFLDIGKSTSNFNGIILPVYDRERTICDCFKYRTKLDNEIFNKAVNAYAADEKKNLVNLSKYAKEMKLYTKVMNVMEVLLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XIS7</accession>
    <name>A0A173XIS7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Autoinducer 2-binding protein lsrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lsrB</name>
        <name evidence="3" type="ORF">ERS852478_00300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577577.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50328">
        <property type="protein sequence ID" value="CUN50328"/>
        <property type="gene ID" value="ERS852478_00300"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015445" evidence="1">
        <location>
            <begin position="25"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="34"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN50328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="342" mass="35882" checksum="B02D49E1C4DCECE8" modified="2016-09-07" version="1">MNKKLVSAILCGAMVLAAATPVMADGGVADGKKIALVGKSAGNAFFEIAANSFKETVEAEGGSVDVVYPEAATADAQIKVLDNLISQKPDAICISANDVNALQAKLEEAMDAGIKVSSFDSAPNKDSRQVFVNQAGTKQVGQALLDAVLDISGGEGQWAVLSATSQAANQNAWIDAMKSIMEGDDKYSKLELVEVAYGDDEPQKSTDQTAALLEKYPDLKVICAPTTVGIAAAAKYLQDNGSACKLTGLGLPSEMQEYTGDDDAHSCPYFYLWDMQGLGKLSAYATAALINGDITGALDETFTAGDLGDYTITEADDGGTEIVLGEPLQFNTENIEEMAKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XMU1</accession>
    <name>A0A173XMU1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutathione import ATP-binding protein GsiA</fullName>
            <ecNumber evidence="1">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gsiA_3</name>
        <name evidence="1" type="ORF">ERS852478_00352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577511.1">
        <property type="nucleotide sequence ID" value="NZ_AXVN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51975">
        <property type="protein sequence ID" value="CUN51975"/>
        <property type="gene ID" value="ERS852478_00352"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN51975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="64" mass="7449" checksum="574AD4F0B0AAA732" modified="2016-09-07" version="1">MVFQMPMESFDPRCTLGDGIGESLRNMGISRTETRRKVEELLERCGLEKEYADRYPQIVYLSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XPR9</accession>
    <name>A0A173XPR9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase factor sigma-70</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00410</name>
        <name evidence="5" type="ORF">ERS852523_04382</name>
        <name evidence="6" type="ORF">GT728_06260</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
            <strain evidence="5 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000111">
        <property type="protein sequence ID" value="CUQ20784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000011">
        <property type="protein sequence ID" value="MZL32820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055154175.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53689">
        <property type="protein sequence ID" value="CUN53689"/>
        <property type="gene ID" value="ERS852478_00410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ20784">
        <property type="protein sequence ID" value="CUQ20784"/>
        <property type="gene ID" value="ERS852523_04382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="125"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN53689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUQ20784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL32820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="186" mass="22028" checksum="68F030F6613439C1" modified="2016-09-07" version="1">MEDTYIIELFWSRDESAIQLVDKKYNSTCYSIAWKILMNREDSEECVNDTWFAAWRYIPPKRPPKLVAFLGKITRGFAIDMLRKKHAAKRTDMHIADITEDVESLNIAIMHNLDEHMEAEKLIEIINRFLGGLSDRDRDIFVQRYWVMESIKNIATRHKMSEGAIKQNLLRNKRKLKKILEKEGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XY29</accession>
    <name>A0A173XY29_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional RNase H/acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199668.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56942">
        <property type="protein sequence ID" value="CUN56942"/>
        <property type="gene ID" value="ERS852478_00485"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="213"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN56942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="357" mass="40281" checksum="9B58A4213168E03F" modified="2016-09-07" version="1">MRSLYLVRHGKPQYPDEHSYCVGQTDFSLSMLGHLQAVLLNEELSDKISRIYCSPLLRAVETAGHMAPELPHIIVSDLSERNLGEWDGLSFDKIRQRWPDIYKARENNPDHPIPGAETPAASGFRFSQAVHKILCASEGDIAVVAHTDVISSYIYALHSGMYSRQRFRLPCGSYYHLEVNEKNNISFSDPSYILPHPELNDGLCLRLRNAVSLPRHVQAHSDAVTGLACCLCNMLESNGYIFDQKLVRSGALLHDIARLQRNHTKTGGELFLQLGYPEISQIISQHHGLLETRLNEAAIVFLADKLIQETQRVTIEKRFADSMSKCKSPEACKAHEQQLEQARKLQDMIQSLCHITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y0F0</accession>
    <name>A0A173Y0F0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted phosphoesterase or phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199678.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57394">
        <property type="protein sequence ID" value="CUN57394"/>
        <property type="gene ID" value="ERS852478_00498"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014578">
        <property type="entry name" value="Pesterase_CT488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033094">
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    </dbReference>
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        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="2"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN57394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="232" mass="27268" checksum="66D21425698AF4EC" modified="2016-09-07" version="1">MSLYAIGDFHLSFTVNKPMDVFDKRWKNHVVKIEKYWKKKVTENDTVVITGDHSWGRDLAECQADLDFIMALPGRKILLRGNHDMFWDAKKTENLNEMFRGKLEFLQNNFYTYEDYALVGTKGYCYEGKDSYEHFLKIRERELGRLRCSFEAAKAAGYEKFIMFLHYPPTSIGEMESPFTLMAQEFGAEKVIYSHCHGEKRYDDSFKGYVDGIEYKLVSGDYLNFKPELVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y0X0</accession>
    <name>A0A173Y0X0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory protein soxS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">soxS_1</name>
        <name evidence="4" type="ORF">ERS852478_00503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57544.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_055199683.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57544">
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        <property type="gene ID" value="ERS852478_00503"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="173"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN57544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="282" mass="33725" checksum="CB83547F5B79268F" modified="2016-09-07" version="1">MEFQHELIIPNEGFPFKVFLFEGGNGNYVREKHWHTSVEIFAVMEGRLDFFVNKDEYPLKAGEQIIINSNEIHSIHAVEKNKTVVLQIPLKQFENYFTAQRYIRFRGQEELVDKKLVSLLRKLYHVYSERKIGYEFRTISIFYEIMYILVKDYRVTETREKDIRHSRRLDALSKITTYMREHYREELKLSDVAATFGYSEAYLSRMFQKYAKINYKTYLQDIRMAYAYRDLLNTDHTISQIALDNGFCSSRGFSREFQKRYGVLPSEMRKQINEKGQKNAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y1F6</accession>
    <name>A0A173Y1F6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase family associated with various cellular activities (AAA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199681.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57483">
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        <property type="gene ID" value="ERS852478_00501"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
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    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="32"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN57483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="517" mass="59853" checksum="2F71721C0521C47C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y667</accession>
    <name>A0A173Y667_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="5">AGPR</shortName>
            <ecNumber evidence="5">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="5">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">argC</name>
        <name evidence="8" type="ORF">ERS852478_00558</name>
        <name evidence="9" type="ORF">GT712_13370</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000027">
        <property type="protein sequence ID" value="MZS90036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380055.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59203">
        <property type="protein sequence ID" value="CUN59203"/>
        <property type="gene ID" value="ERS852478_00558"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="4 5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="7">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN59203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS90036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="346" mass="38386" checksum="72A4F44D39F556EC" modified="2016-09-07" version="1">MIKAGIIGATGYAGNEIVRLLLGHKDVEVAWYGSRSYIDQKYADVYQNFFKLVDAKCMDDNMEALADEVDVIFTATPQGLCASLINEGILSKAKVIDLSADFRIKDVKKYEKWYGIEHKAPQFIDEAVYGLCEINREEIKKARLIANPGCYPTCSTLSIYPLIKEGLIDPSTIIIDAKSGTSGAGRGAKVANLFCEVNENIKAYGVATHRHTPEIEDQLGYACGKEVLINFTPHLIPMNRGILVTAYASLTKDVSYEEVKAVYDKYYENETFVRVLDKDVCPQTKCVEGSNYVDVNFKIDPRTHRVIMMGAMDNLVKGAAGQAVQNMNLMFGFKEAEGLLQVPMCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YCL6</accession>
    <name>A0A173YCL6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <shortName evidence="10">DAC</shortName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">disA</name>
        <name evidence="10" type="synonym">dacA</name>
        <name evidence="13" type="ORF">BWLFYP14_03246</name>
        <name evidence="12" type="ORF">ERS852478_00610</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably a homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate cyclase family. DacA/CdaA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX66969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380116.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60967">
        <property type="protein sequence ID" value="CUN60967"/>
        <property type="gene ID" value="ERS852478_00610"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01499">
        <property type="entry name" value="DacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014046">
        <property type="entry name" value="C-di-AMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034701">
        <property type="entry name" value="CdaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045585">
        <property type="entry name" value="CdaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19293">
        <property type="entry name" value="CdaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004793">
        <property type="entry name" value="UCP004793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00159">
        <property type="entry name" value="TIGR00159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="92"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN60967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX66969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="296" mass="33305" checksum="57F07EF698D17026" modified="2016-09-07" version="1">MQDFSGNLIETLSRLAFPKIGIIDIIQIALIAFFVYQFMVWIKYTHAYTLLKGILVVLLFILIAYIFRMNTILWIFSNLASTLIVGVIVIFQPELRKVLEQLGQKRIMASLIPFDAGKEVKERFTDKTISELVKACFDMGEVKTGALIVIEQNELLTDYIRTGINLDAILTSQLLINIFEHNTPLHDGAVIVRENRIVAATCYLPLSDNMELSKQLGTRHRAGVGISEQTDSVTIIVSEETGQVSVAQGGKLTRSVNSAKLREILVRAQNKQVVDNSKLRHLLKGRVKHEEAKNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YE49</accession>
    <name>A0A173YE49_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="13">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">carB_2</name>
        <name evidence="13" type="synonym">carB</name>
        <name evidence="17" type="ORF">ERS852478_00642</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="13"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN62079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057581.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN62079">
        <property type="protein sequence ID" value="CUN62079"/>
        <property type="gene ID" value="ERS852478_00642"/>
    </dbReference>
    <dbReference type="GeneID" id="66492539"/>
    <dbReference type="eggNOG" id="COG0458">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_A">
        <property type="entry name" value="CPSase_L_chain_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="133"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="675"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="16">
        <location>
            <begin position="934"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="13">
        <location>
            <begin position="934"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="824"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="836"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="838"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUN62079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1071" mass="118242" checksum="99DF35165E886577" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YG54</accession>
    <name>A0A173YG54_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exoglucanase B</fullName>
            <ecNumber evidence="3">3.2.1.91</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbhB</name>
        <name evidence="3" type="ORF">ERS852478_00639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.91" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61985">
        <property type="protein sequence ID" value="CUN61985"/>
        <property type="gene ID" value="ERS852478_00639"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016154" evidence="1">
        <location>
            <begin position="30"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="122"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN61985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="375" mass="42974" checksum="38165EFF75D1EFCE" modified="2016-09-07" version="1">MKYIRKSFSLFWLIAVMLFGTVSASAASAKPETPVLSGTAAGNRVTLNWNKVKKASGYQIFLYYKAYGKYKCVGRIKNRNITSFTLTGSEDKLYTYKIRSYLKQGNKTLYSPSSKALEIKTAPGKPVITRIRVREESGTLIKWKKIKTAEGYQIFRSESEDRGYKRINIVSGNTTFSYTDTGTVSGKTYYYRIRAYVRNQGNVVYSELSDPAEAVMRKTIMIGDSRTDMMKDVVENDNITWICEVGMGYKWLRDTALKTLQEQMKGNEDIFVWLGVNDVYNISNYISLLNEEIPKWKAQGADVYIVALGQVTKDPYVTNEEIEDFNARMKKEVAGAKYADLYSYLKKQGYKTTDGTHYDNETTWKIYRYLMSFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YKH8</accession>
    <name>A0A173YKH8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclodextrin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cycB_2</name>
        <name evidence="2" type="ORF">ERS852478_00672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64093">
        <property type="protein sequence ID" value="CUN64093"/>
        <property type="gene ID" value="ERS852478_00672"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016234" evidence="1">
        <location>
            <begin position="30"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN64093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="421" mass="47307" checksum="767224DA3F4E0E8E" modified="2016-09-07" version="1">MRKNMKKLTVATVIGAMTVTALAPVSAQAKDKTLTVAIWDNGQKAGLQEIMDEFTKETGIKTELQVVEWSSYWTLLEAGASGGDMPDVFWMHSNEAVRYMSNDILLDLTDKVADSDKLEMDKFPEDIKEMYQWDGKTYAVPKDIDTIAMWYNKDMFDEAGIDYPDGSWTWDEFYDIAEKLTKEDGSQYGFAANPSNEQDTWMNIIYSMGGCVLTDDNKSGFDDPNTIKAMEFVDKCVKNVMPPASTMSETGTDVLFGSGKVAMISQGSWMVSGFKDNDYIKEHCDVARLPKDAETGRSVSLYNGLGWAASANTDMPDEAFQLIEWFGTKDMQQKQADLGVTMAAYEGMSDGWVNSVDCFNLQPYMDAMDDIVFRPHTNATLAWWNPMCEELKKPWNDEESMDDACKNIVTIMNDAIAEESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YPM0</accession>
    <name>A0A173YPM0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidylate kinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Cytidylate kinase-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00691</name>
        <name evidence="3" type="ORF">GT712_03235</name>
        <name evidence="2" type="ORF">GT728_03690</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 5 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A1</strain>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706532.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64738">
        <property type="protein sequence ID" value="CUN64738"/>
        <property type="gene ID" value="ERS852478_00691"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN64738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL32318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS88126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="207" mass="23360" checksum="AE960F2A5667A7F7" modified="2016-09-07" version="1">MENFVITIARQYGSGGRTVGKMLAEKLGVSFYDKQIIQMASDESGIDVKLFGQVEEGSSVKASLFNKTGLYKGDLIAPDQKGFVSDENIFNYQAKIATDLAEKESCVIVGRCVNYVFKDRPNTLRVFVHAPWEFRVEKSREKISGSDEEIEKFLRRDDKRKQDYYRKFAGGDWSDATNYDLCLNAGKLGFEKCVDAILAQMNVMGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YV72</accession>
    <name>A0A173YV72_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_01769</name>
        <name evidence="2" type="ORF">ERS852478_00752</name>
        <name evidence="3" type="ORF">GT728_03930</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706471.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66865">
        <property type="protein sequence ID" value="CUN66865"/>
        <property type="gene ID" value="ERS852478_00752"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013378">
        <property type="entry name" value="Listeria/Bacterioides_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042229">
        <property type="entry name" value="Listeria/Bacterioides_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09479">
        <property type="entry name" value="Flg_new"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033732626" evidence="1">
        <location>
            <begin position="34"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN66865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="334" mass="38026" checksum="DE4D781542E511CB" modified="2016-09-07" version="1">MRKQKRQMCVRRMLLFFLACVLICAAPPSAAQAAIMQTAKNSTVQKKKTSTKTVTIETSGGITKKKVKSGGSVILPVEVNKRGYTFLGWSTVPGQTCNPMYQAYQKIQVTKNIHLYPVKYKWNQEPDIYAGGLADSVEKYDKIIFVGDSRTAMLRSTLKQQCSSDSLKKVGFVCKTGEGLDWMKKYGEKELLNEISGMDDNAKPVAVIFNLGVNDLIHKNRESISYDSVASDYASYMNGLSRKLTARNCELFYMSVNPCNTAMKSTRKESEIRGFNNRLRQRLNGNFTWINSYSYLMRCGYTTRCEFRGYTDDGVHYSMRTYKRIYAYAIKQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YW61</accession>
    <name>A0A173YW61_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Lactose transport system permease protein LacF</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Maltose transport system permease protein malF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">malF_1</name>
        <name evidence="10" type="synonym">lacF_6</name>
        <name evidence="10" type="ORF">BWLFYP14_01744</name>
        <name evidence="7" type="ORF">ERS852478_00777</name>
        <name evidence="9" type="ORF">GT712_02875</name>
        <name evidence="8" type="ORF">GT728_04050</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">BIOML-A1</strain>
            <strain evidence="9 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579256.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67787">
        <property type="protein sequence ID" value="CUN67787"/>
        <property type="gene ID" value="ERS852478_00777"/>
    </dbReference>
    <dbReference type="GeneID" id="66493551"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN67787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL32390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS88054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX64913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="302" mass="34078" checksum="111722778372981A" modified="2016-09-07" version="1">MAKNNNHKAVSYNKWGYIFLIPFVVVYLIFQLVPLISTIYNSFFENYRSGLTQIGPNFVGLANYAKLFQGGDIWIYFKNTMIMWVMGFIPQILVSLLLAAWFSNPSLRLKGQRFFKTVIYLPNLIMASAFAMLFFTLFADGGPINAMLMQSGILKQAYSFFSHAWSARTLVAVLNFLMWFGNTTILLMAGMMGIDSSLYEAAEVDGATSSQIFRKITLPLLRPILIYVMITSLIGGMQMFDVPQILTNGTGDPMRSTMTLIMFLNKHLFSKNYGMGGALSVFLFIITGVLSLIVFRFNKIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YX69</accession>
    <name>A0A173YX69_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription termination factor Rho</fullName>
            <ecNumber evidence="6">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rho</name>
        <name evidence="13" type="ORF">BWLFYP14_01751</name>
        <name evidence="10" type="ORF">ERS852478_00769</name>
        <name evidence="11" type="ORF">ERS852523_00573</name>
        <name evidence="12" type="ORF">GT728_04015</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">2789STDY5834863</strain>
            <strain evidence="11 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 17">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP10937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055149491.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000036_gene2418"/>
    <dbReference type="EnsemblBacteria" id="CUN67555">
        <property type="protein sequence ID" value="CUN67555"/>
        <property type="gene ID" value="ERS852478_00769"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10937">
        <property type="protein sequence ID" value="CUP10937"/>
        <property type="gene ID" value="ERS852523_00573"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="9">
        <location>
            <begin position="93"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="209"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="221"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN67555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP10937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL32383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX64928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="465" mass="52649" checksum="5F6FC3E0EC1E3B0A" modified="2016-09-07" version="1">MREKYESLSLATLKDLAKARGLKGVSALRKPELIERMLHEDELEGETKKQETVREKPQQSEVEGNGERIPQYNKTPERTQYHAPAEAVQLDSGERADGILEVLPDGYGFIRCENYLPGENDIYVSPSQIRRFNLKTGDIIKGNIRIKTQGEKFSALLYVTSINGFHPSEGQRRHNFEDMTPIFPNERLIMERPGGTVAMRIVDLISPIGKGQRGMIVSPPKAGKTTLLKDVAKSILRNNPDMHLIILLIDERPEEVTDIREAICGDNVEVIYSTFDELPEHHKRVSEMVIERARRLVEHKKDVTILLDSITRLARAYNLIIPPSGRTLSGGLDPAALHMPKRFFGAARNMREGGSLTILATALVDTGSKMDDVIYEEFKGTGNMELVLDRKLQEKRVFPAIDIQKSGTRREDLLLSKEEQEAVYIMRKALNGMKSEDAVEQILNMFTRTKNNAEFVQTVKKQKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YZ22</accession>
    <name>A0A173YZ22_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thermostable beta-glucosidase B</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bglB_3</name>
        <name evidence="3" type="ORF">ERS852478_00825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199815.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69442">
        <property type="protein sequence ID" value="CUN69442"/>
        <property type="gene ID" value="ERS852478_00825"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="2">
        <location>
            <begin position="353"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN69442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="806" mass="89621" checksum="055F8699AA506202" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z1S1</accession>
    <name>A0A173Z1S1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted DNA-binding protein with PD1-like DNA-binding motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199810.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69115">
        <property type="protein sequence ID" value="CUN69115"/>
        <property type="gene ID" value="ERS852478_00815"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN69115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="145" mass="16503" checksum="F9202E55A17E71DE" modified="2016-09-07" version="1">MDYRKFGECYYIRMDRDDEIISTILKICKKENIRSATFSGIGGCKDAEIQTFIPETGSFEEQRISGMLELVSLNGNVVTGENNTCYHHTHAVFFYKDGERHCMAAGHMKSITVLYTAEIELHPVTGGTIRRKYVPETGTGFWDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z5C2</accession>
    <name>A0A173Z5C2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Colicin V production protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_00842</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN70973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN70973">
        <property type="protein sequence ID" value="CUN70973"/>
        <property type="gene ID" value="ERS852478_00842"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RY3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN70973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="232" mass="26301" checksum="C57258E4B478DF88" modified="2016-09-07" version="1">MALTWAGVITILFLAAACVRGYRRGLIKELVSLVCVFLSMAIVWLINPYVNEFIRENTSIYEKVQESCREFVGEEYSTWTGSGESQTEFINEMNLPELLRNGLVQNNNSDSYQYLAVTTFSDYIAQYLARMAVNGISFLISLLMSTIMVRSITWMLNLVTRLPVLHGMNKVAGALLGAVKFLIVIWIIFLALTIVCNTKAGEAALQIIKKDCILSFIYDRDILIRIFMSIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z7Q2</accession>
    <name>A0A173Z7Q2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">recR</name>
        <name evidence="13" type="ORF">BWLFYP14_01235</name>
        <name evidence="9" type="ORF">ERS852478_00850</name>
        <name evidence="10" type="ORF">ERS852523_02495</name>
        <name evidence="12" type="ORF">GT712_07950</name>
        <name evidence="11" type="ORF">GT728_00995</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000026">
        <property type="protein sequence ID" value="CUP69531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS89003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706922.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000122_gene2851"/>
    <dbReference type="EnsemblBacteria" id="CUN71228">
        <property type="protein sequence ID" value="CUN71228"/>
        <property type="gene ID" value="ERS852478_00850"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP69531">
        <property type="protein sequence ID" value="CUP69531"/>
        <property type="gene ID" value="ERS852523_02495"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="81"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN71228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP69531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL31809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS89003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX64105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="199" mass="22037" checksum="BD36D7B19FB7B632" modified="2016-09-07" version="1">MEYYSSHINKLIEQLSHLPGIGAKSAQRLAFHIMNMPKDQVEQLTSSITGARENVQYCKCCCTLTDREICPICSNDKRDHSVIMVVENTRDLAAYEKTGKFDGVYHVLHGAISPMLGIGPDDIKLKELMQRLAKDEVKEVIIATNSSLEGETTAMYISKLIKPTGIKVSRIASGVPVGGDLEYIDEVTLLRALEGRVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z981</accession>
    <name>A0A173Z981_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flp pilus assembly protein, protease CpaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72240">
        <property type="protein sequence ID" value="CUN72240"/>
        <property type="gene ID" value="ERS852478_00889"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="3">
        <location>
            <begin position="11"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN72240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="141" mass="15510" checksum="88B52CFBD3892FB4" modified="2016-09-07" version="1">MEMNGVKEICVLGFLGINSWIDIRKKQVALLLIIIFAVCGTVWTIYSRRNVPEVLMCVGTGFLFVLISILTEGAVGMGDGWLLMALGTVLYPEEFFSTLFMGMICSAVWSGIMMMGFCRKGSTEIPFVPFLLAGYLGGFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZAV4</accession>
    <name>A0A173ZAV4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-xylosidase</fullName>
            <ecNumber evidence="4">3.2.1.177</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yicI_3</name>
        <name evidence="4" type="ORF">ERS852478_00907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.177" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72780">
        <property type="protein sequence ID" value="CUN72780"/>
        <property type="gene ID" value="ERS852478_00907"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061634">
        <property type="term" value="F:alpha-D-xyloside xylohydrolase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="171"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN72780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="619" mass="70664" checksum="FBCA4426876CB455" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZBL2</accession>
    <name>A0A173ZBL2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059457.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73812">
        <property type="protein sequence ID" value="CUN73812"/>
        <property type="gene ID" value="ERS852478_00941"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031552">
        <property type="entry name" value="ParE-like_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15781">
        <property type="entry name" value="ParE-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN73812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="98" mass="11616" checksum="CA7F4677CEC06076" modified="2016-09-07" version="1">MTQVQILPPAAKFLKKLKDKKLKSLYKEAIEMICEDYSIGEEKTGDLAGMYGYDIYYNKTNYELAYRVRQLDDLIIIIIMAGTRENFYEELKRYIRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZIP8</accession>
    <name>A0A173ZIP8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_8</name>
        <name evidence="7" type="ORF">ERS852478_00998</name>
        <name evidence="8" type="ORF">GT728_13475</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000034">
        <property type="protein sequence ID" value="MZL34187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577888.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75663">
        <property type="protein sequence ID" value="CUN75663"/>
        <property type="gene ID" value="ERS852478_00998"/>
    </dbReference>
    <dbReference type="GeneID" id="66493229"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN75663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL34187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="276" mass="31136" checksum="965A2155882D1D75" modified="2016-09-07" version="1">MKIKKIKVNEIVGTAVTVLIAVLILFPLIWLLVSSFKSDADVIKWPPIFFPTQWLTAQYKYVVDAIPILSMLKNTVVFSVGVTVVSLFFDSMAAYAFSRMHFKGKNLIFGIILLTMMVPFQIIMIPLYIEEYKFKILDTYLGLILPRASSAYGIFMLTSFFENIPKSLDEAARIDGMKEKQIYSRIILPLAKPAFITLGIYHFMNNWNDLIYPMMLTSSVEKRTLSAGLAILVGSNSIKYGPTLAATVISIAPLMILFLFCQRFFMEGIATSGMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZMJ5</accession>
    <name>A0A173ZMJ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative mRNA interferase YoeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yoeB</name>
        <name evidence="5" type="ORF">ERS852478_01022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YoeB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199882.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76415">
        <property type="protein sequence ID" value="CUN76415"/>
        <property type="gene ID" value="ERS852478_01022"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN76415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="88" mass="10513" checksum="E71511013A07BCFA" modified="2016-09-07" version="1">MSNISFSEDAWEDYLYWQLQDKKTLKKINELLKEIQRTPFSGKGEPEKLRGDLNGKWSRRINFKDRLVYEISDETIIVIQCKGHYSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZTD6</accession>
    <name>A0A173ZTD6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HPr family phosphocarrier protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">PTS HPr component phosphorylation site</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Phosphocarrier protein Chr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_00350</name>
        <name evidence="2" type="ORF">ERS852478_01070</name>
        <name evidence="4" type="ORF">GT712_13595</name>
        <name evidence="3" type="ORF">GT728_14265</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000037">
        <property type="protein sequence ID" value="MZL34331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000028">
        <property type="protein sequence ID" value="MZS90077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707401.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79083">
        <property type="protein sequence ID" value="CUN79083"/>
        <property type="gene ID" value="ERS852478_01070"/>
    </dbReference>
    <dbReference type="GeneID" id="66496223"/>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN79083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX67505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="78" mass="8540" checksum="9BDA9E2A50A11B51" modified="2016-09-07" version="1">MKTVKISLNSIDKVKAFVNEISKFDCDFDLVSGRYVIDAKSIMGIFSLDLSKPIDLNIHADGAALDTVMAIVGKYVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZW48</accession>
    <name>A0A173ZW48_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79830">
        <property type="protein sequence ID" value="CUN79830"/>
        <property type="gene ID" value="ERS852478_01092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN79830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="94" mass="11384" checksum="8826BBFB28EF5512" modified="2016-09-07" version="1">MKTCCLVWEIPVIEGEHYNPIMNVIYMQKAKKFLNQLNRYFQDENMDWKCVLDHSACTYNEIFSSEHQAVIFAPEAKTRQWLYKKDFQKKDKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A1X7</accession>
    <name>A0A174A1X7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease Z</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_03099</name>
        <name evidence="2" type="ORF">ERS852478_01135</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704134.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81408">
        <property type="protein sequence ID" value="CUN81408"/>
        <property type="gene ID" value="ERS852478_01135"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="48"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN81408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="266" mass="30798" checksum="7324BAC78A7456C6" modified="2016-09-07" version="1">MKLTILGTGNAKVTKCYNTCFALNEDKEYFMIDGGGGNTILKQLEDAGISWKEIRTIFVTHKHIDHLLGIIWMLRMYCQGMARGQFGGEVTIYGHDEVISLLKQMAEMLLTPKETKFIGDKVHLEEVKDGEDRTILGHRVTFFDILSTKAKQFGFCMEYAEGKKLTCCGDEPYNECEQKYAKNSTWLLHEAFCLFSQADKFKPYEKHHSTVKDACELAQKLEAENLILYHTEDKNISRRKELYTEEGRQYYKGNLWIPDDLEIYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A5W1</accession>
    <name>A0A174A5W1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellobiose phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN84092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199962.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84092">
        <property type="protein sequence ID" value="CUN84092"/>
        <property type="gene ID" value="ERS852478_01209"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd11755">
        <property type="entry name" value="GH94N_ChBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009342">
        <property type="entry name" value="Carb-bd_put_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033432">
        <property type="entry name" value="GH36_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037828">
        <property type="entry name" value="GH94N_ChBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010383">
        <property type="entry name" value="Glyco_hydrolase_94"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17167">
        <property type="entry name" value="Glyco_hydro_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06165">
        <property type="entry name" value="Glyco_transf_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01068">
        <property type="entry name" value="CBM_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBM_X" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN84092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="803" mass="89982" checksum="33C0AF9865FE8A17" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A7A6</accession>
    <name>A0A174A7A6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lon protease 1</fullName>
            <ecNumber evidence="4">3.4.21.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lon1_1</name>
        <name evidence="4" type="ORF">ERS852478_01219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.53" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN84404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199970.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84404">
        <property type="protein sequence ID" value="CUN84404"/>
        <property type="gene ID" value="ERS852478_01219"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="266"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN84404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="496" mass="55107" checksum="84F9F1A5F451B81D" modified="2016-09-07" version="1">MPVFDFSGASDKKPGVQSECTYTTFQSNETETAPEKPIMILDNSSRQWKHHSCGIFTNPIKRTSFEFKEDDGVFSADIISIDSRFVSLLKWLGENHINVRLSGENKENGYAVYKIRETAFGGGTKLSAEDGFLQFMIERLLASSAPAEIVEDEDEEETGDEMKLTSIQSITDFMTCAGRTLPDNIRLWARRNLAVARSHEVSPEERRHAQRALSIMMNIQWKNNYFEAIDPQEARRILDEELYGMESVKQRIIETIIQINRTHTLPAYGLLLVGPAGTGKSQIAYAVARILKLPWTTLDMSSINDPEQLTGSSRIYANAKPGIIMEAFSAAGESNLVFIINELDKAASGKGNGNPADVLLTLLDNLGFTDNYMECMVPTVGVYPIATANDKSQISAPLMSRFAVIDIPDYTSEEKKIIFSKYVLPKVLKRMSLKAEECVVTEAGLNAIVELHKNTSGIRDLEQAAEHIAANALYQIEVDHLTGVTFNADMVRGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ALA3</accession>
    <name>A0A174ALA3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP-sensing transcriptional pleiotropic repressor CodY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">codY</name>
        <name evidence="14" type="ORF">BWLFYP14_01651</name>
        <name evidence="10" type="ORF">ERS852478_01311</name>
        <name evidence="11" type="ORF">ERS852523_00903</name>
        <name evidence="13" type="ORF">GT712_09460</name>
        <name evidence="12" type="ORF">GT728_08175</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">2789STDY5834863</strain>
            <strain evidence="11 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 19">BIOML-A1</strain>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CodY family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000007">
        <property type="protein sequence ID" value="CUP20995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000015">
        <property type="protein sequence ID" value="MZL33176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705703.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000047_gene1262"/>
    <dbReference type="EnsemblBacteria" id="CUN88679">
        <property type="protein sequence ID" value="CUN88679"/>
        <property type="gene ID" value="ERS852478_01311"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20995">
        <property type="protein sequence ID" value="CUP20995"/>
        <property type="gene ID" value="ERS852523_00903"/>
    </dbReference>
    <dbReference type="GeneID" id="66494931"/>
    <dbReference type="eggNOG" id="COG4465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00621">
        <property type="entry name" value="HTH_type_CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014154">
        <property type="entry name" value="CodY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010312">
        <property type="entry name" value="GTP_sensing_CodY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013198">
        <property type="entry name" value="GTP_sensing_HTH_CodY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40062">
        <property type="entry name" value="PTHR40062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06018">
        <property type="entry name" value="CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08222">
        <property type="entry name" value="HTH_CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011572">
        <property type="entry name" value="GTP_sensing_CodY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CodY" evidence="8">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_CodY" evidence="9">
        <location>
            <begin position="195"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN88679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP20995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL33176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS89290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX64795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="261" mass="29110" checksum="A780A4CEDAFECDAE" modified="2016-09-07" version="1">MSVQLLDRTRKINKLLHNSSSSKVVFNDICQVLMETLSSNILVLSKKGKVLGVSLCPGVEEITELIEDKVGGYVDSLLNERFLGVLSTKENVNLQTLGFEHVSSSYQGIINPIDIAGERLGTVFMYRYEKPYDIEDIIVSEYGTTVVGLEMMRAVHEENAEEDRKQQVVKSAFNTLSFSELEAIIHIFDELDGDEGILVASKIADRVGITRSVIVNALRKFESAGVIESRSSGMKGTYIKVLNEVIFDELEEIKAQRNKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AWY8</accession>
    <name>A0A174AWY8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Holliday junction resolvase RecU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852478_01408</name>
        <name evidence="11" type="ORF">ERS852523_00988</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
            <strain evidence="11 13">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RecU family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP24194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055149917.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93142">
        <property type="protein sequence ID" value="CUN93142"/>
        <property type="gene ID" value="ERS852478_01408"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP24194">
        <property type="protein sequence ID" value="CUP24194"/>
        <property type="gene ID" value="ERS852523_00988"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004612">
        <property type="entry name" value="Resolv_RecU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03838">
        <property type="entry name" value="RecU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN93142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP24194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="183" mass="21724" checksum="6D0590155534E899" modified="2016-09-07" version="1">MDTYNRSIRGLKSRSNGEYFERMIIAASRFYEDRGIAVIDKTPEAFKVIKPYNRDRGQFICCFTQQAQPDFKGALMDSTMVLFDAKHTDKGQISRNVVTEEQEECFERYMKMGAMCFLVISLEFEEFYRVPWIVFRDMKKIYGHKYMNREELAPYRVKYNNGVVKYLDGITLRERNEDESTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B3N6</accession>
    <name>A0A174B3N6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage XkdN-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94370">
        <property type="protein sequence ID" value="CUN94370"/>
        <property type="gene ID" value="ERS852478_01448"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014986">
        <property type="entry name" value="XkdN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038559">
        <property type="entry name" value="XkdN-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08890">
        <property type="entry name" value="Phage_TAC_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN94370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="184" mass="20664" checksum="F8620F9FAD0EF060" modified="2016-09-07" version="1">MARTANIENEEPRTTEIDMTEAEADEVLKADMAANEAGYLAGLLDAAENAEEETKKIEIVRNGKLYFVFSIHALADETLYEIRKKYTKYAKNKRTGTKVAEGVDNAKLRSSMIYNATIAEDQEKLWNNKQVQEALRRRGKHIINALDVIDAVLLPGEKENVLAVLDELSGYDTEETKVETAKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B4A9</accession>
    <name>A0A174B4A9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Surfactin synthase subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">srfAA_2</name>
        <name evidence="5" type="synonym">srfAA_1</name>
        <name evidence="5" type="ORF">BWLFYP14_00992</name>
        <name evidence="4" type="ORF">ERS852478_01486</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95667">
        <property type="protein sequence ID" value="CUN95667"/>
        <property type="gene ID" value="ERS852478_01486"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="514"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="1520"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="2517"/>
            <end position="2591"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="1555"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="2552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN95667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX63506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="2994" mass="337062" checksum="AFE7F784E9B0A985" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B522</accession>
    <name>A0A174B522_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704579.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94836">
        <property type="protein sequence ID" value="CUN94836"/>
        <property type="gene ID" value="ERS852478_01461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN94836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="109" mass="12747" checksum="F8FC243803BBC691" modified="2016-09-07" version="1">MRTVIIKVDSKEAEYIERLDYERGFTKDVLQRIIESHMEDPDVINSPAFKAYQKQGAELDAQFSMAVAELEKKYIPEILKHHKTKWNLEYKTGELKVDILCNCEIEGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B5V1</accession>
    <name>A0A174B5V1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retron-type reverse transcriptase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200108.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94968">
        <property type="protein sequence ID" value="CUN94968"/>
        <property type="gene ID" value="ERS852478_01465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN94968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="425" mass="49617" checksum="7D392449C1745818" modified="2016-09-07" version="1">MKKCCKNVNILADDFIEDSIYEALDEKWKRSDVAKYLHGRTSSMSLQAMKRLLRNTDERDLMVSGLVHTVAESLRYEIQNRCLKVEPIQYSWRQDGVNGKIREIGVESVKQLILDEIASEGLDELWRRKLGYHQYASIKGKGQLGGKKAIEHQIRKKYSMSRYAWKGDVKKCYPSVDTRKLKRMLEHDVKNEVLLYLVYFLIGTYKQGLNIGSGLSQFLCNYYLAKAYVYVLGLHKVRKHRDGATESKRLVYFCIMYMDDILLIGAREADVKRAARALEKYLLKEYGLTIKPDADLFPIDYRIKTGNKYENYREKDKAERRGKPIDMMGYVIYREHTEIRNKIFLRARKAYSVAWYCMKNKKEIPLHTAYKCTSYYGWFKHTDSKYVKDKYNIDAVCAAAKRRISKHAKSEIYGTSARSALAACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BCD3</accession>
    <name>A0A174BCD3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hhaIM</name>
        <name evidence="8" type="ORF">ERS852478_01532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200128.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97376">
        <property type="protein sequence ID" value="CUN97376"/>
        <property type="gene ID" value="ERS852478_01532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN97376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="306" mass="33669" checksum="0287DD6197F5A376" modified="2016-09-07" version="1">MSALTHFSLFSGIGGIDLAAEAAGFTTVCQCEWADFPMEVLKKHWPQVPKFRDITTVTKEAFFEKTGQETTTLISGGFPCQPFSSAGKQRGFEDERYLWPEMLRVIRELHPSWVLGENVAGFIHLGLDKTVFDLEQAGYAVRVFVLPAVAVGAWHERKRTFIIGHAASHAPCQRHGGCGENCRCADDPDRELPKIQSQRNRMDGAAVMGGLQTAGQPAGGCETEPRLGGMADGIPPEMDGHSMWAKEPAQIPYLISDPPANVAKRLKTLGNAVVPPQVYPILRYIAEIETGRCRNRQQGGDRIWNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BIH6</accession>
    <name>A0A174BIH6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057311.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00504">
        <property type="protein sequence ID" value="CUO00504"/>
        <property type="gene ID" value="ERS852478_01598"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043743">
        <property type="entry name" value="DUF5688"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18941">
        <property type="entry name" value="DUF5688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO00504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="362" mass="41056" checksum="51F0B3C9140E34FF" modified="2016-09-07" version="1">MMNRKEFYEYVKDNVKEYLPESYKDAEIKLQEVEKNNGLKLTGITIPNGDQRIVPTVYLDSLYQEYIHGKDVDSCVGDVADMRIEAQGKAEFFDMGVTDILDYEKMKDKLQMRICDKEWNTDLLADKVVTEHGDFAAYYAVNLEENGEGISSIPVTVSLMNEWGVSAEQIQANAMVADRKRGVTLMDMNEIIKSMIFGEEPENLLNEKMDMEAMENPMFCLTNKAKMNGASLLLQEDIRKQIGECLGSDYFVIPSSIHEVLILPDNGIFQVPELNAMVQEVNETQVERQEQLSDKVQFCDKKTAVMENAERREARLEKEKAAEKVEVKGGIHGRLEKAKAEIKAKEGDKVPKNKSKELATAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BUR7</accession>
    <name>A0A174BUR7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">rplO</name>
        <name evidence="14" type="ORF">BWLFYP14_00274</name>
        <name evidence="10" type="ORF">ERS852478_01676</name>
        <name evidence="11" type="ORF">ERS852523_01276</name>
        <name evidence="13" type="ORF">GT712_08895</name>
        <name evidence="12" type="ORF">GT728_04785</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">2789STDY5834863</strain>
            <strain evidence="11 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 19">BIOML-A1</strain>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707274.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2965"/>
    <dbReference type="EnsemblBacteria" id="CUO03276">
        <property type="protein sequence ID" value="CUO03276"/>
        <property type="gene ID" value="ERS852478_01676"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33079">
        <property type="protein sequence ID" value="CUP33079"/>
        <property type="gene ID" value="ERS852523_01276"/>
    </dbReference>
    <dbReference type="GeneID" id="66496139"/>
    <dbReference type="eggNOG" id="COG0200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="28"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO03276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP33079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL32535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS89184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX67433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="146" mass="15502" checksum="06793DA216C5B5BF" modified="2016-09-07" version="1">MELSNLRPAEGSKHSDNFRRGRGHGSGNGKTAGKGHKGQLARSGHKKPGFEGGQMPLYRRLPKRGFKNRNTKEIIAINVDVLNRFEDGAEVTAESLLASGAISKIADGVKILGNGELTKKLNVKVNAVSETAKSKIEAAGGTVEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BWJ9</accession>
    <name>A0A174BWJ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacterial protein of uncharacterized function (DUF885)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200315.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05541">
        <property type="protein sequence ID" value="CUO05541"/>
        <property type="gene ID" value="ERS852478_01722"/>
    </dbReference>
    <dbReference type="GeneID" id="66492352"/>
    <dbReference type="eggNOG" id="COG4805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010281">
        <property type="entry name" value="DUF885"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33361">
        <property type="entry name" value="PTHR33361"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05960">
        <property type="entry name" value="DUF885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO05541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="586" mass="66697" checksum="DDA87E25A04A5474" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BX20</accession>
    <name>A0A174BX20_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">trmB</name>
        <name evidence="2" type="ORF">ERS852478_01711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05177">
        <property type="protein sequence ID" value="CUO05177"/>
        <property type="gene ID" value="ERS852478_01711"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
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        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO05177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="221" mass="25897" checksum="B7F65B4E9877D94D" modified="2016-09-07" version="1">MRLRNIPGAQDAILESPYVVQEPQTKKGHWGEVFAKKQPLHIEVGMGKGRFLMDLARLHPDINYIGIEMYDSVLLRALQKREELEENGEVYSNLFFMRVDARLLPEIFEKGEVDKIYLNFSDPWPKARHAKRRLTSREFLARYDQILVPDGKVEFKTDNKELFEFSLEEVEEAGWNLEASTFDLHHNEEMVQGNVMTEYEEKFSSMGNPICKMVISRECHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BX57</accession>
    <name>A0A174BX57_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">V-type ATP synthase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_01717</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
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    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05374.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_055200177.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05374">
        <property type="protein sequence ID" value="CUO05374"/>
        <property type="gene ID" value="ERS852478_01717"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
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    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO05374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="195" mass="22214" checksum="1221C52627F5FB53" modified="2016-09-07" version="1">MTIDEKLSHFYDITVEEAHEKAAAILDEHKAALEKMAEEHKTLSEENAQTQIKAETARARREINKALSAEQLTIKRDWTRKQNELKEKIFSEVKGLLESFTKTPEYENYLTAKIKEALDFAGNDEITIYLSPEDRSLAEKLQHTTDTAIQLAKDSFLGGIRATIPQKNILIDHSFAGNFEAAYKEFKFDGGPEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C486</accession>
    <name>A0A174C486_9FIRM</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01794</name>
        <name evidence="4" type="ORF">ERS852523_03621</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
            <strain evidence="4 6">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="ERS852478_01794"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ01478">
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        <property type="gene ID" value="ERS852523_03621"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PsiE"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO07783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUQ01478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="148" mass="16625" checksum="A893BB66B721D19F" modified="2016-09-07" version="1">MSPKRQVNHNIRKHFNTIIYNISRYAEIALSMVILLVIALAGFRLIMEVADTSVMSMDTEFFSTFLSQALSLVVGVEFVKMLCQHSAQTVVEVLMFATARQMVVEHLGPAETLLGVLSIAVLFAIRKYLMTDNDDMNAHNCPKNTEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C7U3</accession>
    <name>A0A174C7U3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Redoxin domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Stage IV sporulation protein H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">stoA</name>
        <name evidence="5" type="ORF">ERS852478_01832</name>
        <name evidence="6" type="ORF">GT728_18270</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO09033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000069">
        <property type="protein sequence ID" value="MZL35070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577995.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000069.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09033">
        <property type="protein sequence ID" value="CUO09033"/>
        <property type="gene ID" value="ERS852478_01832"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252666" evidence="3">
        <location>
            <begin position="31"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="243"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO09033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL35070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="400" mass="43755" checksum="8889DC4A64D2D181" modified="2016-09-07" version="1">MKNRRMRLMAIFAAGVLSVTSMGGIVTAHAEETLSVPAEEAGAGAVQMDGKDAQAAEDGSVAASEGLIAGSFKPSEIAQPAQDTYEYPFLGMKLGISKDLKEQMEKKNISMFTDERWNDNADAVTYATASWCTLTDEQKDAEVDKMGTGYDDWLKSLSRVGVIGMYDEESQKDLDRITGCTEHKELGTSSDGKYKYYLSTNKDADADLLKDVEGIEVTLTEMTPFQMLSAFDQPQDTSDSTEATEGTNVGKFETTGVDGKTYTQDIFSKYDLTMVNIFTTWCSPCVNEIPDLEKLYQEMKDKGVGVVGVTLDTVGSGGKQDQEAVKKAQVLQKKTKASYPFLIPDSGMMNGRLNGISAFPETFFVDKNGNIVGETYSGSHSLDEWKEIVEKELENVTEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CRR2</accession>
    <name>A0A174CRR2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3343 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF3343)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01974</name>
        <name evidence="4" type="ORF">GT712_18340</name>
        <name evidence="3" type="ORF">GT728_09060</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO14899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000059">
        <property type="protein sequence ID" value="MZS90952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707504.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO14899">
        <property type="protein sequence ID" value="CUO14899"/>
        <property type="gene ID" value="ERS852478_01974"/>
    </dbReference>
    <dbReference type="GeneID" id="66495592"/>
    <dbReference type="eggNOG" id="ENOG5033A63">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021778">
        <property type="entry name" value="Se/S_carrier-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11823">
        <property type="entry name" value="DUF3343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3343" evidence="1">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO14899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="78" mass="9008" checksum="DE23352D2D34257F" modified="2016-09-07" version="1">MKEKVLTTVVTFETTTQAIAMERECKKNKFTGRLIPVPREISASCGLAWKCGEQNEEETASYMKEQDLEYEKIYRILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CT77</accession>
    <name>A0A174CT77_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200491.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16771">
        <property type="protein sequence ID" value="CUO16771"/>
        <property type="gene ID" value="ERS852478_02032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025584">
        <property type="entry name" value="Cthe_2159"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14262">
        <property type="entry name" value="Cthe_2159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019475" evidence="2">
        <location>
            <begin position="27"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO16771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="391" mass="38956" checksum="7F2242469E4DF439" modified="2016-09-07" version="1">MKKKLLAGILALALCSTNMPPQTIFAGEFTSGNPDVVSEEEIPEIFTNEEQEAAGETDEELSVFSSEEVPEFNDAPDEAMAAAENAQNREIDLTTDVTAGVYTISSAGNYKFTCSNNEPTGNRIVINGAGIPAQHKINIYLNNVNINTSDDPALQIQSSVQAQVYIYLEGINNLNSEKRAALQTDNAAKLTIDNSPDNSPNTTGELIATGSFGAGIGGDQWKSSSDITIRGGSVTATSSYGAGIGGGRGQTNGNITIRGGSVTATSGSGAGIGGGQGNNGSNITIRGGSVTATSDSGAGIGGGSNGGDGSDITIRGGSVTATSDSGAGIGGGSNWGDGSDITISGGSVTATSDSGAGIGGGSKGAGRNIAISGGSVKAYSDKRPGINCPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DAX2</accession>
    <name>A0A174DAX2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 17" type="primary">metK</name>
        <name evidence="17" type="ORF">ERS852478_02202</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380675.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22694">
        <property type="protein sequence ID" value="CUO22694"/>
        <property type="gene ID" value="ERS852478_02202"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="123"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="242"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="254"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUO22694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="393" mass="43173" checksum="F6472167AE7279D9" modified="2016-09-07" version="1">MEKILFTSESVTEGHPDKMCDAISDAILDALMEKDPMSRVACETATTTGLVLVMGEITTNAYVDIQKIVRDTIREIGYTRGKYGFDADTCAVITAIDEQSADIALGVDKALEAKMGEDEIDAIGAGDQGIQFGYASNETEEYMPYAINMAHKLARQLTKIRKDGTLKYLRPDGKTQVTVEYDEAGKPIRIDAVVCSTQHDPDVTQEQIHEDIKKYVFDEIIPADMVDENTKYFINPTGRFVIGGPHGDSGLTGRKIIVDTYGGTGRHGGGAFSGKDCTKVDRSAAYAARYVAKNIVAAGLADKCEIQLSYAIGVAHPTSIHVETFGTGKLSDTKLVEIVRENFDLRPAGIIKMLDLRRPIYRQTAAYGHFGRTDVDLPWEHLDKVDDLKKYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DIV3</accession>
    <name>A0A174DIV3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in cyanobacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705519.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25423">
        <property type="protein sequence ID" value="CUO25423"/>
        <property type="gene ID" value="ERS852478_02274"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO25423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="169" mass="19904" checksum="635E3373198409A6" modified="2016-09-07" version="1">MSNALPIEDLSKTYLEHSMVINNFVIKIGSQIKDSLCRVFGDGVQYEWRENDDKVIIPDVSIICNLRDRKNISFTGIPRFVMEVLSNATEEYDRHEKMNIYCKVGVSEYWIVDWRKKSVEIYLFDFKEDGTGYPYLYKTVTAQNKEDLHLVMFPNLKITFDELFDIGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DLM6</accession>
    <name>A0A174DLM6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bacillibactin transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">btr_3</name>
        <name evidence="5" type="ORF">ERS852478_02307</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705564.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26471">
        <property type="protein sequence ID" value="CUO26471"/>
        <property type="gene ID" value="ERS852478_02307"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="184"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO26471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="282" mass="33608" checksum="9AD8F009FA6BAABA" modified="2016-09-07" version="1">MHDLDHNEDRPRGTYEFPFEFHHIDHTHPRYVMSYHWHVEYEIIRILEGSLTVTLDEKSFTAVKNDVIFVHSGILHSGIPHDCVYQCIVFDMNTFLKNNPVCGEYIQKILHQETMLFPHFSDEHPQILNCISVLFDAMYEKDTGYELTVFGQFYHFFGLIFSNHYFIENPTRTRRDYKRILQLKQVLEFIEKNYANPITLQELSASVSMSPKYFCRFFSEMTHQTPVDYLNRQRIEEACLQLAATDDSITEIAYRNGFNDLSYFIRTFKKYKGMTPGKYKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DMM4</accession>
    <name>A0A174DMM4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993370.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25355">
        <property type="protein sequence ID" value="CUO25355"/>
        <property type="gene ID" value="ERS852478_02272"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033UBB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO25355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="131" mass="14408" checksum="19A3AAA0B5C00A4E" modified="2016-09-07" version="1">MAKINKYWGYVAIGALTAAAAGAVAALIAKKGSCKEDFDFEDDFDDFDLTDEKETAKEDQEPAEDFQSWEHTGEQSATDDTENEEAADTDDSEKSSDKAAEVEIKDAEEEEDADEPENFEETMDAASESEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DNI2</accession>
    <name>A0A174DNI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino-acid carrier protein AlsT</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Na+/alanine symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">alsT_2</name>
        <name evidence="10" type="ORF">BWLFYP14_01532</name>
        <name evidence="9" type="ORF">ERS852478_02286</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053744.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000023.1"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DPU9</accession>
    <name>A0A174DPU9_9FIRM</name>
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        <name evidence="2" type="ORF">ERS852478_02289</name>
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        <name type="scientific">Blautia wexlerae</name>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 6">2789STDY5834863</strain>
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        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
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            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 9">BIOML-A1</strain>
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        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        </location>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="340" mass="36366" checksum="D64EBBD056561ACA" modified="2016-09-07" version="1">MKKRVLAIAATAMATMMMASPVMAQDFKIGICNYVDDASLNQIVDNIQSRLEEIGKEKDVNFDVSYDNCNADANVMEQIISDFQADNVDLMVGIATPVAMRMQSATEGTDTPVVFSAVSDPVGSGLVEDLDAPGANITGTSDYLDTASIMKLIQAVNPDVKKIGLLYDIGQDSSTTAIQEAKDYLDKEGIEYVERTGTTTDEVQLAADALVADGVDAVFTPTDNTIMTAELSIYEKFIDAGIPQYTGADSFALNGAFVGYGVDYANLGQKTADMIADILMNDADPATTSVETFDNGTATVNTETCEGLGLDLETVKKDFEPLCTQVNEIVTAESFDDVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E2U0</accession>
    <name>A0A174E2U0_9FIRM</name>
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        <name evidence="6" type="primary">cobQ_2</name>
        <name evidence="4" type="synonym">cobQ</name>
        <name evidence="7" type="synonym">cobQ_1</name>
        <name evidence="7" type="ORF">BWLFYP14_00112</name>
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        <name type="scientific">Blautia wexlerae</name>
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    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053407.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30769">
        <property type="protein sequence ID" value="CUO30769"/>
        <property type="gene ID" value="ERS852478_02424"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="251"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO30769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="502" mass="55013" checksum="9583E504AEB88296" modified="2016-09-07" version="1">MAKAIMVQGTMSNAGKSLLAAGLCRIFKQDGYRVAPFKSQNMALNSFITEEGLEMGRAQVMQAEAAGIKPSVLMNPILLKPTNDVGSQVIVNGEVLGTMSARDYFKYKKKLVPDIMKAYDKLASENDIIVIEGAGSPAEINLKTEDIVNMGMAKMAKAPVLLVGDIDRGGVFAQLIGTVELLEADEREMVKGLIINKFRGDKTILDPGVQMLEERSHIPVVGVAPYLDIQVEDEDSLTERFDRKQEVDLIDIAVIRVPRISNFTDFNPLESIPGVSLRYVQHVSELKNPDMIILPGTKNTMEDLLWMRANGLEAAVLKEAAKGKIIFGICGGYQMLGETLSDPHHVEAGGTIKGMGLLPMDTVFAEKKTRTRVSGRFLELEGELQALSGAELEGYEIHMGETVLKGEAGHSVSIEDQVSGECKEDGAYRKNVCGTYVHGVFDREDVAEAVIRVLGEKKGIDVSQMTGIDFAAFKETQYDILAAELRKHLDMKKIYDILEQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E3S5</accession>
    <name>A0A174E3S5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="2">PPIase</shortName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ppiA</name>
        <name evidence="7" type="ORF">BWLFYP14_00097</name>
        <name evidence="5" type="ORF">ERS852478_02439</name>
        <name evidence="6" type="ORF">GT728_01810</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO31158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL31969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993724.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31158">
        <property type="protein sequence ID" value="CUO31158"/>
        <property type="gene ID" value="ERS852478_02439"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034048213" description="Peptidyl-prolyl cis-trans isomerase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="110"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO31158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL31969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="272" mass="28819" checksum="C1AC53125B79E9F5" modified="2016-09-07" version="1">MKRKLLAALCVTAMSAGLLAGCGSSDKTEESTKTEETAKEETSSQEETETKAASSDSDNVASEEEAEKAGFSDGSDEKSDSADTDSENKDSSDSSTTSVLLDTSKELTGIHHAEIEVKDYGTIDVELDADTAPITVTNFVKLAQEGFYDGLTFHRIMDGFMIQGGDPNGDGTGGSEENIKGEFSNNGVDNDISHTRGTISMARASDPDSASSQFFIVQADSTFLDGDYAGFGHVTEGMDIVDKICEDAKPTDDNGTIPSDQQPVIEKITITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E4T1</accession>
    <name>A0A174E4T1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_C39_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02140</name>
        <name evidence="3" type="ORF">ERS852478_02480</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32773">
        <property type="protein sequence ID" value="CUO32773"/>
        <property type="gene ID" value="ERS852478_02480"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252901" description="Peptidase_C39_2 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_C39_2" evidence="2">
        <location>
            <begin position="98"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO32773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="258" mass="29466" checksum="431C791399DDA794" modified="2016-09-07" version="1">MGKSCSKIILLILILAAWIVVTVRAKKTEEGIILTDAYKKQIMESAEWKKIFLHTENYPDILLEDLKRNPEMLEFVEGYNDVHKKSSEGLTFEEQKKKVPLFIQWDKRWGYEPYGTSDIGISGCGPTCMAMVIYSLTRNTEAIPPVLAQKSMNEGYYVDGIGTSWKFMREAALDYGVIASQFDMLGEQEMADRLKDGNLIICAMGPGDFTNSGHFIVIYDYSRKKFSVNDPFSYTNSSKKWEYTTLISQCQQIWVYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E710</accession>
    <name>A0A174E710_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="7">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="7">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">aspS</name>
        <name evidence="9" type="ORF">ERS852478_02514</name>
        <name evidence="11" type="ORF">GT712_02285</name>
        <name evidence="10" type="ORF">GT728_13300</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">BIOML-A1</strain>
            <strain evidence="11 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000033">
        <property type="protein sequence ID" value="MZL34152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703718.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33574">
        <property type="protein sequence ID" value="CUO33574"/>
        <property type="gene ID" value="ERS852478_02514"/>
    </dbReference>
    <dbReference type="GeneID" id="66495265"/>
    <dbReference type="eggNOG" id="COG0173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="151"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="7">
        <location>
            <begin position="206"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="542"/>
            <end position="545"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO33574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL34152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS87950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="598" mass="67749" checksum="ECB99AA1DF97D182" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E7M4</accession>
    <name>A0A174E7M4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02159</name>
        <name evidence="2" type="ORF">ERS852478_02461</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703633.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32295">
        <property type="protein sequence ID" value="CUO32295"/>
        <property type="gene ID" value="ERS852478_02461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO32295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="96" mass="11285" checksum="4BC169F36A80E5F1" modified="2016-09-07" version="1">MDGSTIPYYVVEERKKLNRCIEEAPNDYEKEIYRAIRNMPVPYEKLNEILENSRDIITSKQNRKAKNRKFFATGIPIIFMILVVAVYTLLNKQGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EC02</accession>
    <name>A0A174EC02_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmid mobilization relaxosome protein MobC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mobC</name>
        <name evidence="4" type="ORF">BWLFYP14_02420</name>
        <name evidence="2" type="ORF">ERS852478_02552</name>
        <name evidence="3" type="ORF">GT728_02285</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000050">
        <property type="protein sequence ID" value="VUX66048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703806.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35211">
        <property type="protein sequence ID" value="CUO35211"/>
        <property type="gene ID" value="ERS852478_02552"/>
    </dbReference>
    <dbReference type="GeneID" id="66495296"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008687">
        <property type="entry name" value="MobC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05713">
        <property type="entry name" value="MobC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobC" evidence="1">
        <location>
            <begin position="62"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO35211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="113" mass="13634" checksum="782FF69FE87E6ECA" modified="2016-09-07" version="1">MSKRTRIHPVQFYLNDDEQYILEEKYRLSRMKSKSAFLRKMILYGFVYEVDYSHIRKMNTLLGNISSNLNQITHRINSSNTVYQKDLDDIKELMEKIWQLQKSMVSKQPLIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EF94</accession>
    <name>A0A174EF94_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">der</name>
        <name evidence="11" type="ORF">ERS852478_02592</name>
        <name evidence="12" type="ORF">GT728_02705</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057462.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36411">
        <property type="protein sequence ID" value="CUO36411"/>
        <property type="gene ID" value="ERS852478_02592"/>
    </dbReference>
    <dbReference type="GeneID" id="66494121"/>
    <dbReference type="eggNOG" id="COG1160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="4"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="178"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="231"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="296"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO36411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL32129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="441" mass="49233" checksum="0C1D8969F18F1548" modified="2016-09-07" version="1">MSKPVVAIVGRPNVGKSTLFNALAGEKISIVKDTPGVTRDRIYADVTWLDKTFTMIDTGGIEPDSSDIILSQMREQAQIAIDTADVIIFITDVHQGLVDSDAKVADMLRRSGKPVVLVVNKVDSIQKFMMDVYEFYNLGIGEPIPISAANRMGLGDMLDEVAKHFPEDADTDEEDEIPRIAIVGKPNVGKSSLVNKLLGEDRVIVSDIAGTTRDAVDTRVKWQGKDYIFIDTAGLRRKGKVKEEIERYSVIRTVTAVERADVVIVMIDASEGVTEQDAKIAGIAHERGKGVIIAVNKWDAIEKNDKTIYKHTNRIREVLAYMPYAELVFISAKTGLRISRMFETIDAVIENQTLRIQTGVLNEILSEAVAMQQPPSDKGKRLKIYYMTQVAVKPPTFVIFVNDKELMHFSYTRYLENKIRDAFGFAGTSLKFIIRERGEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EJ12</accession>
    <name>A0A174EJ12_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <ecNumber evidence="3">5.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gpmA</name>
        <name evidence="3" type="ORF">ERS852478_02604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379995.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000136.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36708">
        <property type="protein sequence ID" value="CUO36708"/>
        <property type="gene ID" value="ERS852478_02604"/>
    </dbReference>
    <dbReference type="GeneID" id="66494109"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO36708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="204" mass="23418" checksum="09676CB30EA67ECD" modified="2016-09-07" version="1">MLIYVLRHGITQWNKLKKVQGAMDIPLAPEGIELAKRTGEALKDVPFDICFTSPLARARQTAHYVLGNRQIPVIEDKRIQEIDFGVLEGSRFKDEQGKIISHEMEIFFEEPQKFERPQNGENISDILKRTREFWVEKTTDPALADKTILVSSHGCAVRALLQNVYQDPEHFWHGCVPPNCSINLLEVKDGKARFLEEDKVYSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EKY0</accession>
    <name>A0A174EKY0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">phoR_5</name>
        <name evidence="9" type="synonym">phoR_4</name>
        <name evidence="9" type="ORF">BWLFYP14_00920</name>
        <name evidence="8" type="ORF">ERS852478_02657</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993325.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38662">
        <property type="protein sequence ID" value="CUO38662"/>
        <property type="gene ID" value="ERS852478_02657"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="677"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="706"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO38662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX63442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="891" mass="99897" checksum="049CD5905B82EF31" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ELR6</accession>
    <name>A0A174ELR6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_01457</name>
        <name evidence="2" type="ORF">ERS852478_02620</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO37165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000033">
        <property type="protein sequence ID" value="VUX64603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37165">
        <property type="protein sequence ID" value="CUO37165"/>
        <property type="gene ID" value="ERS852478_02620"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033732860" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO37165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX64603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="55" mass="6259" checksum="6377E3375DFA508A" modified="2016-09-07" version="1">MTALLLILVFLLFQTFVLLCCVAAGNDAASQEISDQEQMEFIREWKKIHCSSPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EQY4</accession>
    <name>A0A174EQY4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-binding protein HU 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">HB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">HU family DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hupA</name>
        <name evidence="9" type="ORF">BWLFYP14_00595</name>
        <name evidence="5" type="ORF">ERS852478_02709</name>
        <name evidence="6" type="ORF">ERS852523_02549</name>
        <name evidence="8" type="ORF">GT712_18380</name>
        <name evidence="7" type="ORF">GT728_09460</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000027">
        <property type="protein sequence ID" value="CUP71109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000019">
        <property type="protein sequence ID" value="MZL33418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000060">
        <property type="protein sequence ID" value="MZS90959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707945.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000099_gene778"/>
    <dbReference type="EnsemblBacteria" id="CUO40512">
        <property type="protein sequence ID" value="CUO40512"/>
        <property type="gene ID" value="ERS852478_02709"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP71109">
        <property type="protein sequence ID" value="CUP71109"/>
        <property type="gene ID" value="ERS852523_02549"/>
    </dbReference>
    <dbReference type="GeneID" id="66495151"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO40512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP71109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS90959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX62817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="92" mass="10017" checksum="711FEC8D97CE0A68" modified="2016-09-07" version="1">MNKTELVAAMAKETNLSKKDVEDVLKSFVDVVSKELKNGGKIQLVGFGTFEVSERAAREGRNPQTGETMKIEASKSPKFKAGKALKDMVNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ETT6</accession>
    <name>A0A174ETT6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_02694</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379942.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40078">
        <property type="protein sequence ID" value="CUO40078"/>
        <property type="gene ID" value="ERS852478_02694"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="403"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO40078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="512" mass="60744" checksum="6990C4F746ABE0E9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EVU8</accession>
    <name>A0A174EVU8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose-5-phosphate isomerase B</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Sugar phosphate isomerase YwlF</fullName>
            <ecNumber evidence="5">5.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpiB</name>
        <name evidence="5" type="synonym">ywlF</name>
        <name evidence="5" type="ORF">BWLFYP14_00590</name>
        <name evidence="4" type="ORF">ERS852478_02715</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EC" id="5.3.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200857.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40639">
        <property type="protein sequence ID" value="CUO40639"/>
        <property type="gene ID" value="ERS852478_02715"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="7"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="65"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO40639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX62812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="143" mass="15602" checksum="BEC80DED8BF9F1FA" modified="2016-09-07" version="1">MIALGCDHGGYELKQEIKKYLDEKGIEYKDYGCDSLDSVDYPVYAKKVAHAILDGECEKGILICGTGIGISITANKIKGIRAAVCTDCFTAEATRLHNDANILALGGRVVGPGLALKIVDTFLNTPFSNDERHIRRINQIETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F5E5</accession>
    <name>A0A174F5E5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02823</name>
        <name evidence="4" type="ORF">GT712_17425</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000050">
        <property type="protein sequence ID" value="MZS90788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059736.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000118.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43969">
        <property type="protein sequence ID" value="CUO43969"/>
        <property type="gene ID" value="ERS852478_02823"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033731602" evidence="2">
        <location>
            <begin position="30"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO43969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="260" mass="28260" checksum="EB4FF3019482C7E5" modified="2016-09-07" version="1">MIFTKKYRTGQIVLTACIAAVCMFSDVHGAEVAGPPAPKSKSALTQKPEATPMPEATPIPASTPTPEQETETDKQNPADQGTLSKPDHPDTISADKLVFIGDSRTEGLRDAVNDDSIWSCLSSMGYDWMVSTGVPQVEDQIEDNTAVIILMGVNDLYHVNDYISYINSKAAEWGNRGAQTYFVSVGPVQNDPYCSNAEIESFNAAMQASLSGVTYIDVYSHLVSEGFSTVDGTHYPDSVSVDIYNYILDHLEEQMSGIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FC68</accession>
    <name>A0A174FC68_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plasmid recombination enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_03412</name>
        <name evidence="4" type="ORF">ERS852478_02900</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmid mobilization pre family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46538">
        <property type="protein sequence ID" value="CUO46538"/>
        <property type="gene ID" value="ERS852478_02900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001668">
        <property type="entry name" value="Mob_Pre"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01076">
        <property type="entry name" value="Mob_Pre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="433"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="214"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="350"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO46538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX67135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="471" mass="55662" checksum="61C77EAF68543248" modified="2016-09-07" version="1">MIKRTISGMIGVGSLAHNRRDFVAENVNPDRVQLNICYKNENLKEVYKELFDDAVERYNVGKRKDRQIANYYEKIRQGKQEKLFHEVIFQIGNREDMAVGTTEGDLAVRVLDEYMKDFQKRNPSLRVFSCYLHQDEATPHLHIDFVPYVTNWKGKGMDTRVSLKQALKSLGFQGGNKHDTELNQWINHEKEVLAEIAKQHGIEWEQKGTHEEHLDVYNFKKKERKKEVQELEQEKEYLTAENEGLTSQIADARADIKLLEEEKIQFQKDKETAEKRAGKAEMELKKLEDRREFLQPVMDNVSKEIKEYGMIKTFLPEATTLERAVTYRDKKIKPLFIEMKNKIGAMAVQVKELTRERDSWKSKFQKKKQEHEKTKKELAEVQKDYQKLSGEKEILQELADRYNRLLRMLGKDMVERLVQDDIRIQAELEAKKQKEQMPKKISDRIPWAKERSEEHNAQIKKNKAKYRGMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FE14</accession>
    <name>A0A174FE14_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_03400</name>
        <name evidence="1" type="ORF">ERS852478_02915</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201005.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46909">
        <property type="protein sequence ID" value="CUO46909"/>
        <property type="gene ID" value="ERS852478_02915"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026989">
        <property type="entry name" value="TnpV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14198">
        <property type="entry name" value="TnpV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO46909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX67123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="124" mass="14897" checksum="B8069007848E64D7" modified="2016-09-07" version="1">MKKQIYDEKNGMSYTLHGDYYLPDLVLREEEPTYGKYGMLRKQFLKEHRSARYQYLLLTGKLNEHLNQIDQESRKQMEMLMGQMVERQGVTEELKVQDQMKWVRLMNNIKASAEEIVLKNMVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FEK1</accession>
    <name>A0A174FEK1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5348 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_03411</name>
        <name evidence="2" type="ORF">ERS852478_02901</name>
        <name evidence="3" type="ORF">GT712_17985</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000055">
        <property type="protein sequence ID" value="MZS90886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705148.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46555">
        <property type="protein sequence ID" value="CUO46555"/>
        <property type="gene ID" value="ERS852478_02901"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035255">
        <property type="entry name" value="DUF5348"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17295">
        <property type="entry name" value="DUF5348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5348" evidence="1">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO46555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX67134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="75" mass="8707" checksum="CD68DCCCCFF9EB94" modified="2016-09-07" version="1">MKQGRLGYNSSNDRYGLLSSDLWIDTGFHCGEGLEVLVDDKWIRTRMEMNSAREWYLVGTPYCGDLEYVQARIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FFQ2</accession>
    <name>A0A174FFQ2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5348 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201008.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46955">
        <property type="protein sequence ID" value="CUO46955"/>
        <property type="gene ID" value="ERS852478_02917"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035255">
        <property type="entry name" value="DUF5348"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17295">
        <property type="entry name" value="DUF5348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5348" evidence="1">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO46955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="75" mass="8709" checksum="CFF2D44ED60D54D4" modified="2016-09-07" version="1">MKQGRLGYNSSNDRYGLLASDLWIDTGFHCGEGLEVLVHDKWVRTRMEMNPAREWYLVGTPYCGDLEYVQARIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FIL0</accession>
    <name>A0A174FIL0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thermostable beta-glucosidase B</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bglB_5</name>
        <name evidence="5" type="ORF">ERS852478_03005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201068.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50013">
        <property type="protein sequence ID" value="CUO50013"/>
        <property type="gene ID" value="ERS852478_03005"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="310"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO50013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="921" mass="101985" checksum="0B99B90D0F333D77" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FJJ3</accession>
    <name>A0A174FJJ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-proFAR isomerase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisA</name>
        <name evidence="10" type="ORF">BWLFYP14_03577</name>
        <name evidence="8" type="ORF">ERS852478_02973</name>
        <name evidence="9" type="ORF">GT712_01760</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706264.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48799">
        <property type="protein sequence ID" value="CUO48799"/>
        <property type="gene ID" value="ERS852478_02973"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO48799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS87849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX67302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="255" mass="28077" checksum="679246B4B0D1008D" modified="2016-09-07" version="1">MKFRPCIDIHNGKVKQIVGGSLTDVQDQASENFVSEQDASFYAELYKKAGIKGGHVILLNGHDSPYYESTKEQAILALHTYPGGLQIGGGVNPENAGEYLSAGASHVIVTSYVFKDGRISWENLNKMKETVGKEKLVLDLSCRRKDGKYYIVTDRWQKFTDVTMTLDIMKELGSYCDEFLVHAVDVEGKARGVETELASLLGEYKGNPVTYAGGVGSMKDIEDLRKYGKDRLDVTVGSALDLFGGNISFSELIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FKI8</accession>
    <name>A0A174FKI8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ytfT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ytfT</name>
        <name evidence="7" type="ORF">ERS852478_03013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201073.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50221">
        <property type="protein sequence ID" value="CUO50221"/>
        <property type="gene ID" value="ERS852478_03013"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO50221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="351" mass="36832" checksum="9F4524FF57BCD36B" modified="2016-09-07" version="1">MNKSKLKKITSARLFLPIVCLIAVLLLNVIRTPDFFNVSIRNGVLYGYIVDVINRASELVILAIGMTLVTAASGGQDISVGAIMAVAAAVCCQILSGGQVSVNDYQNPVILAVIAALLASALCGAFNGFLVSKLNIQPMVATLILYTAGRGIAQLITNGQITYIRVDSFKMAGGYIGKCPIPTPIFFAIITVVIVYLILKKTALGLYIESVGINGKAARLVGLNSTMIKFLTYVICGVLAGIAGIVASSRIYSADANNIGLNLEMDAILAVALGGNFLGGGKFSLIGSVIGAYTIQALTTTLYAMNVKADQLPVYKAIVVVIIVTLQSDVFKKYIANLKAKKSVAAEGGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FTN7</accession>
    <name>A0A174FTN7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH deoR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_03113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005335900.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53614">
        <property type="protein sequence ID" value="CUO53614"/>
        <property type="gene ID" value="ERS852478_03113"/>
    </dbReference>
    <dbReference type="GeneID" id="43514871"/>
    <dbReference type="GeneID" id="64114872"/>
    <dbReference type="GeneID" id="66495701"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO53614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="113" mass="12429" checksum="245CF9A9E38539BE" modified="2016-09-07" version="1">MNFEFMTIDTPLPPCMPFPRALTGFPVSSTAKVMYCRMLDAMLFRGQADENGILFVCFPITAIAAVLSRSLMTVKRSLNELETAGLIMRVRQGVGEPNRIYVLIPGKEGATLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FZ77</accession>
    <name>A0A174FZ77_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipoprotein-releasing system ATP-binding protein LolD</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lolD_4</name>
        <name evidence="5" type="ORF">ERS852478_03157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO54991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201214.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000075.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54991">
        <property type="protein sequence ID" value="CUO54991"/>
        <property type="gene ID" value="ERS852478_03157"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO54991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="227" mass="25329" checksum="145DA1AEAAE72DB0" modified="2016-09-07" version="1">MNLLEVKNICKTYGSGETAVKALRNVSFSVPKGEYVAIVGESGSGKSTLLNMIGALDMPTSGKVLIDGKDIFSMNDRKLTVFRRRNIGFIFQAFNLIPELTVEQNMIFPLLLDYQKPDKRYLEELLTVLNLKDRRNHLPSQLSGGQQQRVAIGRALITRPSLILADEPTGNLDSQNSSEVIALLKETSKKYEQIIIMITHNRSIAQTADRVLQVSDGTLTDFGRCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G5Z7</accession>
    <name>A0A174G5Z7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="8">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">potA_1</name>
        <name evidence="8" type="synonym">potA</name>
        <name evidence="12" type="ORF">BWLFYP14_02775</name>
        <name evidence="10" type="ORF">ERS852478_03191</name>
        <name evidence="11" type="ORF">ERS852523_01927</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">2789STDY5834863</strain>
            <strain evidence="11 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000018">
        <property type="protein sequence ID" value="CUP53397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000009_gene1462"/>
    <dbReference type="EnsemblBacteria" id="CUO56330">
        <property type="protein sequence ID" value="CUO56330"/>
        <property type="gene ID" value="ERS852478_03191"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP53397">
        <property type="protein sequence ID" value="CUP53397"/>
        <property type="gene ID" value="ERS852523_01927"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015594">
        <property type="term" value="F:ABC-type putrescine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03300">
        <property type="entry name" value="ABC_PotA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017879">
        <property type="entry name" value="PotA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO56330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP53397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX66401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="348" mass="39256" checksum="5ED5C40CD3332E2D" modified="2016-09-07" version="1">MMNKLIELKNLTKNFDDQQVLRGINLDIYEKEFLTLLGPSGCGKTTTLRIIAGFEEPSDGEVLFNGIEISKLPPYKREVNTVFQKYALFPHLNVAENIGFGLNLKKVDKTVIAQKVERMLKMVGLEGFGKRDVTLLSGGQQQRVAIARALVNEPKVLLLDEPLGALDAKIRKQMQVELKKIQQEVGITFIYVTHDQEEALSMSDTVVVMNNGEIQQIGSPTDIYNEPENRFVAGFIGESNIIEGTMIRDYLVAFDGFEFECVDKGFEDNEEIEVVLRPEDLDIVDPGQAKIRGIVRNITFKGVHYEILIETELRTYMVHTTDYAEVGREVGLKFGPEDIHVMCKMGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G9S8</accession>
    <name>A0A174G9S8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_03482</name>
        <name evidence="2" type="ORF">ERS852478_03265</name>
        <name evidence="3" type="ORF">GT712_16840</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO58691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000046">
        <property type="protein sequence ID" value="MZS90679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705124.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58691">
        <property type="protein sequence ID" value="CUO58691"/>
        <property type="gene ID" value="ERS852478_03265"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8CD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX67207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="544" mass="65058" checksum="0A5263D74CCD41CC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GAS2</accession>
    <name>A0A174GAS2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_03483</name>
        <name evidence="1" type="ORF">ERS852478_03266</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO58727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705122.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58727">
        <property type="protein sequence ID" value="CUO58727"/>
        <property type="gene ID" value="ERS852478_03266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045707">
        <property type="entry name" value="DUF6063"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19539">
        <property type="entry name" value="DUF6063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO58727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX67208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="246" mass="28579" checksum="3C78848E7DFAF509" modified="2016-09-07" version="1">MAYEAEEIRTSQEIFYYLLEHHELREEDDQLLYKAYTEEESIRNLVKSQGEIAGSNVERYGNVIYLIPKEENNFLGFSKQQLKGTLCKSGATDKDYYLSQFVILTLLVEFFDGQGSSSKSREYMRVGELMNCLSARLKEGAAEETTTEEEEDGKNPKDTAGISFKILYETYEALKSDDRGSRMKTTKEGFIYNILMFLQKQGLIEYVVQDEMIKTTRKLDNFMDWNLLNQNNYQRVLRVLGVAKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GEI7</accession>
    <name>A0A174GEI7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="6">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="6">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">gatC</name>
        <name evidence="8" type="ORF">ERS852478_03329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380268.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60863">
        <property type="protein sequence ID" value="CUO60863"/>
        <property type="gene ID" value="ERS852478_03329"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="PTHR15004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO60863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="97" mass="11024" checksum="46C3BA60C7B001A3" modified="2016-09-07" version="1">MAKIIDDETMENVCILSKLSLSEEEKEKAKAEMQKMLDYVEKLDELDTSEVEPMSHIFQDENVFREDVVTNGDNKEAMLANAPKAKEGQYQVPKTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GVI9</accession>
    <name>A0A174GVI9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02281</name>
        <name evidence="1" type="ORF">ERS852478_03447</name>
        <name evidence="2" type="ORF">GT712_16205</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000042">
        <property type="protein sequence ID" value="MZS90560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704384.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000068.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64545">
        <property type="protein sequence ID" value="CUO64545"/>
        <property type="gene ID" value="ERS852478_03447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO64545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS90560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="188" mass="22085" checksum="81377C99AF39FAD2" modified="2016-09-07" version="1">MIESELYYLVKSYRDAIEQAHKKNRFCKWPFNQFPEACCGQASDILARFLGEQGIYTKVVSGSDSNTTHAWLVLDDSILQKNIQRAEEATDYEEVNKMNRILEGYGYNKEINIYPYCDLDSILRGCTIIDITGSQSQFRLDSKYFNYNIPIYIGEMDDFHNLFDINSINEFRNDDKLDNIYRIVQQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GY26</accession>
    <name>A0A174GY26_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4825 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_01606</name>
        <name evidence="3" type="ORF">ERS852478_03546</name>
        <name evidence="5" type="ORF">GT712_09260</name>
        <name evidence="4" type="ORF">GT728_08375</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">BIOML-A1</strain>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000015">
        <property type="protein sequence ID" value="MZL33212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705641.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67652">
        <property type="protein sequence ID" value="CUO67652"/>
        <property type="gene ID" value="ERS852478_03546"/>
    </dbReference>
    <dbReference type="GeneID" id="66494972"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032250">
        <property type="entry name" value="DUF4825"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16107">
        <property type="entry name" value="DUF4825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252941" evidence="1">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4825" evidence="2">
        <location>
            <begin position="33"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO67652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX64752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="126" mass="14036" checksum="2DFEBD2A938E4E54" modified="2016-09-07" version="1">MKKKVLAIMLIAMSIMLISACGKKEKLYEIPDLSQYKTDYVGDSSNVINIVSGQEYPAGYSYDSIEIQSETEPYGLTVFLKDEPSAAKLEDELQVNADMTFDLIGNLGTIDYKTADSKEIIASYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZA5</accession>
    <name>A0A174GZA5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trxA_6</name>
        <name evidence="8" type="synonym">trxA_5</name>
        <name evidence="8" type="ORF">BWLFYP14_02358</name>
        <name evidence="7" type="ORF">ERS852478_03488</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005330449.1">
        <property type="nucleotide sequence ID" value="NZ_WWVP01000127.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65885">
        <property type="protein sequence ID" value="CUO65885"/>
        <property type="gene ID" value="ERS852478_03488"/>
    </dbReference>
    <dbReference type="GeneID" id="42420898"/>
    <dbReference type="GeneID" id="67479307"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO65885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX65988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="107" mass="12197" checksum="21426896ED42DF78" modified="2016-09-07" version="1">MTSININKEKFGQLIHKEKPVLVDFWAPWCGYCRRIGAAYEKISEEYSDILIAGKVNIDEEPQIAEAEKIEIIPTLVLYRDGKAIDSIVAPESKIMIENFINEALEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZK3</accession>
    <name>A0A174GZK3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201421.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000052.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67421">
        <property type="protein sequence ID" value="CUO67421"/>
        <property type="gene ID" value="ERS852478_03537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046191">
        <property type="entry name" value="DUF6219"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19727">
        <property type="entry name" value="DUF6219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO67421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="72" mass="8173" checksum="B130CB9C84CD6D22" modified="2016-09-07" version="1">MKAHKYWSLGALAAMIGIFYTGYKNMKSAHKYFACSSLFCMIIAIYSGHEMISGKSKKRKTLFPMENSKPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HT88</accession>
    <name>A0A174HT88_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cph2_5</name>
        <name evidence="7" type="ORF">ERS852478_03821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000054">
        <property type="protein sequence ID" value="CUO76075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76075">
        <property type="protein sequence ID" value="CUO76075"/>
        <property type="gene ID" value="ERS852478_03821"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="6">
        <location>
            <begin position="543"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="5">
        <location>
            <begin position="679"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO76075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="933" mass="108748" checksum="D45A37D7E218417C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JAN1</accession>
    <name>A0A174JAN1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01986</name>
        <name evidence="4" type="ORF">ERS852523_00097</name>
        <name evidence="5" type="ORF">GT728_09000</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO96734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707524.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2262"/>
    <dbReference type="EnsemblBacteria" id="CUO15299">
        <property type="protein sequence ID" value="CUO15299"/>
        <property type="gene ID" value="ERS852478_01986"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96734">
        <property type="protein sequence ID" value="CUO96734"/>
        <property type="gene ID" value="ERS852523_00097"/>
    </dbReference>
    <dbReference type="GeneID" id="66495605"/>
    <dbReference type="eggNOG" id="ENOG50333Z5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO15299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO96734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL33330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="246" mass="28118" checksum="FBBDA22CE1600A60" modified="2016-09-07" version="1">MADKNQDKNQSKNRAEQAEEHDESVLNPEIKNESDLSKKERRLIEKEKLKGMGPKKKLEYIWMYYKPAIFGVIAVIALIFGIKDYYEQSKIKTVLSMTVVNSMANDTETPEQKIKETLGYKDDPYSKVEIGVNLTTDSEMAEFDYNAQMAYVAQIQAGSIDIMVMPEKLYQTLKKNEPFADLKELMGEEAFEKFGMQTDTTHISITDSELEQELGVIYDPVCIAVPYSAPNQENAVKWIKSLDSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JTL3</accession>
    <name>A0A174JTL3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02156</name>
        <name evidence="1" type="ORF">ERS852478_02464</name>
        <name evidence="2" type="ORF">ERS852523_00302</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000003">
        <property type="protein sequence ID" value="CUP03102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32375">
        <property type="protein sequence ID" value="CUO32375"/>
        <property type="gene ID" value="ERS852478_02464"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03102">
        <property type="protein sequence ID" value="CUP03102"/>
        <property type="gene ID" value="ERS852523_00302"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO32375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP03102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="235" mass="26370" checksum="D39E7B79AB1C2EA1" modified="2016-09-07" version="1">MKRKKIDSFTLFVILLLALILTLLGMLLAGMKEEKRQFTVLLPLGDLAYDEDFLQKAKKIKGIKEIWPVIEVPVVIKIEDYTETTTFSGIDMNAFGKNPTQNELGKMPLLLLGNGSLRDMKDYNNHAISKKQQEKFLEMGENLNIFYSLDEKEKDTSKATDDLTTLSGNSARGPQTSYMPCKATVVTEGNEIYIPISQAQDLCREIGEPSEISKVYLKINGKNNLENAKKILSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M861</accession>
    <name>A0A174M861_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional sulfur carrier protein/thiazole synthase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_01329</name>
        <name evidence="1" type="ORF">ERS852478_00959</name>
        <name evidence="2" type="ORF">ERS852523_01187</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000009">
        <property type="protein sequence ID" value="CUP30185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707075.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000012_gene3091"/>
    <dbReference type="EnsemblBacteria" id="CUN74375">
        <property type="protein sequence ID" value="CUN74375"/>
        <property type="gene ID" value="ERS852478_00959"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP30185">
        <property type="protein sequence ID" value="CUP30185"/>
        <property type="gene ID" value="ERS852523_01187"/>
    </dbReference>
    <dbReference type="GeneID" id="66493257"/>
    <dbReference type="eggNOG" id="COG2104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34472">
        <property type="entry name" value="PTHR34472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN74375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP30185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX64291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="67" mass="7501" checksum="48FDEF7CC34422EA" modified="2016-09-07" version="1">MLITVNGKTKELQNTLTIGQYLEENSYVPSQIAVELNERILSKAEYSTTVLHENDILEIVSFMGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MH39</accession>
    <name>A0A174MH39_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsH</name>
        <name evidence="11" type="ORF">BWLFYP14_00269</name>
        <name evidence="7" type="ORF">ERS852478_01671</name>
        <name evidence="8" type="ORF">ERS852523_01281</name>
        <name evidence="10" type="ORF">GT712_08920</name>
        <name evidence="9" type="ORF">GT728_04760</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707269.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2970"/>
    <dbReference type="EnsemblBacteria" id="CUO03040">
        <property type="protein sequence ID" value="CUO03040"/>
        <property type="gene ID" value="ERS852478_01671"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33245">
        <property type="protein sequence ID" value="CUP33245"/>
        <property type="gene ID" value="ERS852523_01281"/>
    </dbReference>
    <dbReference type="GeneID" id="66496134"/>
    <dbReference type="eggNOG" id="COG0096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO03040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP33245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL32530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS89189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX67428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="133" mass="14506" checksum="5B4BC50C149AC0FB" modified="2016-09-07" version="1">MTMSDPIADMLTRIRNANTAKHDTVDVPASKMKTAIANILVDEGYIAKYDLVEDGVVKTLHITLKYGEDKNEKIITGLKRISKPGLRIYAGKDQLPKVLGGLGIAILSTNKGVITDKEARKLQVGGEVLAFVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174Q1J4</accession>
    <name>A0A174Q1J4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Orotate phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_00922</name>
        <name evidence="1" type="ORF">ERS852478_02659</name>
        <name evidence="2" type="ORF">ERS852523_02290</name>
        <name evidence="4" type="ORF">GT712_04890</name>
        <name evidence="3" type="ORF">GT728_07060</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000023">
        <property type="protein sequence ID" value="CUP63969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000012">
        <property type="protein sequence ID" value="MZL32965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000007">
        <property type="protein sequence ID" value="MZS88440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707815.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000031_gene341"/>
    <dbReference type="EnsemblBacteria" id="CUO38730">
        <property type="protein sequence ID" value="CUO38730"/>
        <property type="gene ID" value="ERS852478_02659"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP63969">
        <property type="protein sequence ID" value="CUP63969"/>
        <property type="gene ID" value="ERS852523_02290"/>
    </dbReference>
    <dbReference type="GeneID" id="66492679"/>
    <dbReference type="eggNOG" id="COG0461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO38730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP63969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX63444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="214" mass="23559" checksum="BF68FAC9CD9558F0" modified="2016-09-07" version="1">MNLENMTKIYARGDSRIQLKVIPGHFVTSQSHITHYLDLTTMKSRTAEAQNIAHELAANYEVSTPVDTIICMDGLEVIGAYLSEELTKAGIFSLNAHQTIYVITPESSNSGQIIFRDNFQPMIKGKNVLILNGSITTGSTLSKAIESILYYGGTIRGIAAIFSRVDSVASLPVYSIFNTKDIPDYHSYSSTKCPMCQRQQKIDAIVSSYGYSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174S3Z4</accession>
    <name>A0A174S3Z4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inner membrane protein ypdA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Sensor histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ypdA_6</name>
        <name evidence="5" type="synonym">ypdA_5</name>
        <name evidence="5" type="ORF">ERS852478_03001</name>
        <name evidence="6" type="ORF">ERS852523_03205</name>
        <name evidence="7" type="ORF">GT728_10070</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">2789STDY5834863</strain>
            <strain evidence="6 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO49890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000042">
        <property type="protein sequence ID" value="CUP90165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000021">
        <property type="protein sequence ID" value="MZL33534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577753.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000010_gene2783"/>
    <dbReference type="EnsemblBacteria" id="CUO49890">
        <property type="protein sequence ID" value="CUO49890"/>
        <property type="gene ID" value="ERS852478_03001"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP90165">
        <property type="protein sequence ID" value="CUP90165"/>
        <property type="gene ID" value="ERS852523_03205"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="4">
        <location>
            <begin position="371"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="3">
        <location>
            <begin position="467"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="335"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO49890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP90165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="577" mass="66595" checksum="C8BD795A7BE0DBC3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SSQ5</accession>
    <name>A0A174SSQ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HPr kinase/phosphorylase</fullName>
            <shortName evidence="10">HPrK/P</shortName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
            <ecNumber evidence="10">2.7.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HPr(Ser) kinase/phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 14" type="primary">hprK</name>
        <name evidence="17" type="ORF">BWLFYP14_02887</name>
        <name evidence="13" type="ORF">ERS852478_02840</name>
        <name evidence="14" type="ORF">ERS852523_03596</name>
        <name evidence="16" type="ORF">GT712_17590</name>
        <name evidence="15" type="ORF">GT728_14470</name>
    </gene>
    <organism evidence="14 19">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 18">2789STDY5834863</strain>
            <strain evidence="14 19">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="15 21 22" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 22">BIOML-A1</strain>
            <strain evidence="16 21">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="17 20" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46600"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr protein]-L-serine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:46604"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The Walker A ATP-binding motif also binds Pi and PPi.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the HPrK/P family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="EC" id="2.7.4.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000056">
        <property type="protein sequence ID" value="CUQ00773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000038">
        <property type="protein sequence ID" value="MZL34371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000052">
        <property type="protein sequence ID" value="MZS90821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000064">
        <property type="protein sequence ID" value="VUX66510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705888.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000066_gene3228"/>
    <dbReference type="EnsemblBacteria" id="CUO44671">
        <property type="protein sequence ID" value="CUO44671"/>
        <property type="gene ID" value="ERS852478_02840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ00773">
        <property type="protein sequence ID" value="CUQ00773"/>
        <property type="gene ID" value="ERS852523_03596"/>
    </dbReference>
    <dbReference type="GeneID" id="66494769"/>
    <dbReference type="eggNOG" id="COG1493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01918">
        <property type="entry name" value="HprK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01249">
        <property type="entry name" value="HPr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003755">
        <property type="entry name" value="HPr(Ser)_kin/Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011104">
        <property type="entry name" value="Hpr_kin/Pase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011126">
        <property type="entry name" value="Hpr_kin/Pase_Hpr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF1">
        <property type="entry name" value="PTHR30305:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07475">
        <property type="entry name" value="Hpr_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02603">
        <property type="entry name" value="Hpr_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00679">
        <property type="entry name" value="hpr-ser"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 10 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 10 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hpr_kinase_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Hpr_kinase_C" evidence="12">
        <location>
            <begin position="131"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of both phosphorylation and dephosphorylation" evidence="10">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of dephosphorylation" evidence="10">
        <location>
            <begin position="265"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity" evidence="10">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="154"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO44671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUQ00773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL34371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZS90821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VUX66510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="311" mass="35277" checksum="F41036A4047058F7" modified="2016-09-07" version="1">MKGVQLTKLVQELGLHNLTPEIDLSEIVIKTAEINRPALQLTGYLEHFANERVQIIGYVEYTYLMQLSDEERKFKYERFISSKIPCVIFSTMTRPSQDMIDLAVKYNVPTFVTERTTSSFMAEIIRWLGVQLAPCISIHGVLVDVYGEGVLITGESGIGKSEAALELIKRGHRLVSDDVVELRKVSDVTLVGSAPDITRHFIELRGIGIIDVKTLFGVESVKDTQSVDLVIKLEEWDRDKEYDRLGLHEEYTEYLGNKIVCHSLPIRPGRNLAIIVESAAVNHRQKKMGYNAAEELYKRVQANLAKKREEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174T166</accession>
    <name>A0A174T166_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Ribose transport system permease protein RbsC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rbsC_5</name>
        <name evidence="9" type="synonym">rbsC_2</name>
        <name evidence="9" type="ORF">BWLFYP14_01039</name>
        <name evidence="7" type="ORF">ERS852478_02808</name>
        <name evidence="8" type="ORF">ERS852523_03634</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
            <strain evidence="8 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000058">
        <property type="protein sequence ID" value="CUQ01857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059727.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43533">
        <property type="protein sequence ID" value="CUO43533"/>
        <property type="gene ID" value="ERS852478_02808"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ01857">
        <property type="protein sequence ID" value="CUQ01857"/>
        <property type="gene ID" value="ERS852523_03634"/>
    </dbReference>
    <dbReference type="GeneID" id="66494719"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO43533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUQ01857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX63666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="312" mass="33424" checksum="D8F846208B2C223C" modified="2016-09-07" version="1">MKKLKQSQYYGIGLLVLMLVVFWAVFKVLAPTTFGSPEKLATYMKSALIYAVGGCGLYFICVMGPFDMSVGANIVLSSIIACNASEKFGYAGLIIAPLICGTIIGLINGIVYIKLHISSLIVTCALSLIYEAFSVYATNGKNVILSADYRAFGDYPVNLILALIAYLLCAFILKYTKIGTYTYAIGSNEVVAKNMGVNVPKYKIVAFTLAGFFFGLQAILTISFGTSMTSASNLSSMSRNFTPLMGTFFGLAFKKYGHPVIAIVIGEMIIQLMFNGFVALGAPTTIQNVVTGVALLVIVALTTKPVKGLVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174TW58</accession>
    <name>A0A174TW58_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Urease subunit gamma</fullName>
            <ecNumber evidence="4 5">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Urea amidohydrolase subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ureA_1</name>
        <name evidence="4 8" type="synonym">ureA</name>
        <name evidence="10" type="ORF">BWLFYP14_03499</name>
        <name evidence="6" type="ORF">ERS852478_03283</name>
        <name evidence="7" type="ORF">ERS852523_04088</name>
        <name evidence="9" type="ORF">GT712_01225</name>
        <name evidence="8" type="ORF">GT728_13070</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the urease gamma subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="4 5"/>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO59156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000080">
        <property type="protein sequence ID" value="CUQ13316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000032">
        <property type="protein sequence ID" value="MZL34106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705098.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000010_gene2761"/>
    <dbReference type="EnsemblBacteria" id="CUO59156">
        <property type="protein sequence ID" value="CUO59156"/>
        <property type="gene ID" value="ERS852478_03283"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ13316">
        <property type="protein sequence ID" value="CUQ13316"/>
        <property type="gene ID" value="ERS852523_04088"/>
    </dbReference>
    <dbReference type="GeneID" id="66495408"/>
    <dbReference type="eggNOG" id="COG0831">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00739">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012010">
        <property type="entry name" value="Urease_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001223">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="SSF54111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO59156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUQ13316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL34106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS87744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX67224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="100" mass="11180" checksum="B39365D23945FB1A" modified="2016-09-07" version="1">MRLNPKEQEKLMLHMAGNLAKERKERGLKLNYVEALAYISSELLELARDGKTVVELMQLGTKILTKDDVMDGVADMIGEVQVEATFPDGTKLVTVHNPIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WME8</accession>
    <name>A0A173WME8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SSP-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sspC2</name>
        <name evidence="4" type="ORF">ERS852478_00002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">SASP are bound to spore DNA. They are double-stranded DNA-binding proteins that cause DNA to change to an a-like conformation. They protect the DNA backbone from chemical and enzymatic cleavage and are thus involved in dormant spore's high resistance to UV light.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha/beta-type SASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN40672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN40672">
        <property type="protein sequence ID" value="CUN40672"/>
        <property type="gene ID" value="ERS852478_00002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001448">
        <property type="entry name" value="SASP_alpha/beta-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018126">
        <property type="entry name" value="SASP_alpha/beta-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038300">
        <property type="entry name" value="SASP_sf_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00269">
        <property type="entry name" value="SASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00304">
        <property type="entry name" value="SASP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00684">
        <property type="entry name" value="SASP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN40672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="109" mass="11924" checksum="49F895A4E62BDFE8" modified="2016-09-07" version="1">MSNTKSSNQTAVPEAKGALDRFKFEVANELGVPLTDGYNGNLTSKQNGSVGGYMVKKIVSEQPLNFNSIFYIIPRVIVNYRTTFPGISLLIFLFHPLLKASLVAQSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WMW4</accession>
    <name>A0A173WMW4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytosol non-specific dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pepD</name>
        <name evidence="2" type="ORF">ERS852478_00008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.13.18" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN40843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993878.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN40843">
        <property type="protein sequence ID" value="CUN40843"/>
        <property type="gene ID" value="ERS852478_00008"/>
    </dbReference>
    <dbReference type="GeneID" id="66492923"/>
    <dbReference type="eggNOG" id="COG2195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103046">
        <property type="term" value="F:alanylglutamate dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03890">
        <property type="entry name" value="M20_pepD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001160">
        <property type="entry name" value="Peptidase_M20C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43501">
        <property type="entry name" value="PTHR43501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016599">
        <property type="entry name" value="Xaa-His_dipept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00934">
        <property type="entry name" value="XHISDIPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01893">
        <property type="entry name" value="aa-his-dipept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="209"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN40843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="483" mass="53052" checksum="C143418EA422AA09" modified="2016-09-07" version="1">MAVLENCEPKRVFHYFEEICKIPHGSGNTKQISDYLVQFAKDHDLKYVQDEMNNVVIYKPGTAGYENAPVVIIQGHMDMVCEKRPDVEHDFTKDGLNLSVEGDYVSANGTTLGGDDGIAVAYGLALLESDTIAHPPLEVFITVDEEIGLLGAVGFDCSVLKGRRFINLDSEAEGSLWISCAGGLSGVSHIPVTRLDAEGEKLTVKISGLMGGHSGAEIDKNRANANSLLGKFLHGLDEKTDFELISVQGGQKDNAITREATAEILVLEENVDAVREYAASVQGAWREEYAGTDEGITVTVEDEGKQEVRVLHPTSKEKVIFFLVNVPYGVQKMSGTIKGLVETSTNIGILKTSENEVMGSSSIRSSVETARDSLSDKIAYLTEFLGGEYERQGVYPAWEYRKDSPLRDKMVEVYEEMYGQKPNVVAIHAGLECGLFYKKMEGLDCVSLGPDMKDIHTSEEVLSISSTERVWKYLVKVLEALKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WN64</accession>
    <name>A0A173WN64_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Signal peptidase I</fullName>
            <ecNumber evidence="4 6">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lepB</name>
        <name evidence="8" type="ORF">ERS852478_00013</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 6"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41009">
        <property type="protein sequence ID" value="CUN41009"/>
        <property type="gene ID" value="ERS852478_00013"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="7">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN41009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="174" mass="19859" checksum="1A82F1DFF9046215" modified="2016-09-07" version="1">MIIIVVVTVTLVNSVVLINAKIPSESMEKTIMTGDRIFGFRLAYGLNLDFFGHEISKKIKDPERFDIVIFKYPDDESKLFIKRVIGLPGEKVQIKDGKVYINDSEIPLDDSFVPEKPRGSFGPYEVPENSYFVLGDNRNHSKDSRCWKSTSFVTFDEIVGKAVIRYYPSVKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WSD6</accession>
    <name>A0A173WSD6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stage IV sporulation protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">spoIVA</name>
        <name evidence="1" type="ORF">ERS852478_00051</name>
        <name evidence="2" type="ORF">ERS852523_00716</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP15550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055149629.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1415"/>
    <dbReference type="EnsemblBacteria" id="CUN42234">
        <property type="protein sequence ID" value="CUN42234"/>
        <property type="gene ID" value="ERS852478_00051"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15550">
        <property type="protein sequence ID" value="CUP15550"/>
        <property type="gene ID" value="ERS852523_00716"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014201">
        <property type="entry name" value="Spore_IV_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09547">
        <property type="entry name" value="Spore_IV_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007466">
        <property type="entry name" value="SpoIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02836">
        <property type="entry name" value="spore_IV_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN42234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP15550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="489" mass="55423" checksum="C59949FB5F1E48C3" modified="2016-09-07" version="1">MENFQVYRDIQARTGGDIYIGVVGPVRTGKSTFIRRFMELVALPQMSDTKQAEIRDQLPLSGSGKIITTAETKFIPKEAVPITLGEDQQVKIRLIDSVGFLVKGASGQTEDGKERMVKTPWFEQAIPFREAARIGTQKVIQEHSTIGIVVTTDGSFGELPRDNFPEAEEKTIQELKKQQKPFIVLVNSQMPYKDAALKTAEEIQQKYKVTALTVNCDQLRKEDIARILEKVLYEFPVSQIQFFIPRWVEMLPLEHELKQQILSQIRDKMKSMQHIRDITKESVKLSGPYVQDSLLEDVGLSDGTVKIRIRIKEEYYYRMLSQMSGIEMESEYELIHTMQELVHMKEEYVKVQAALEAVRGTGYGVVVPNLDEIEIAQPEVIRQGNKYGVKIKSKSPSIHMIKANIETEIAPIVGTEQQAKDLIQYIDEGSQRGESIWETNIFGKSIEQLVQDGIRSKIAAISEESQVKLQDTMQKIVNDSKGGLVCIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WYY4</accession>
    <name>A0A173WYY4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Chaperone protein dnaK</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mreB_1</name>
        <name evidence="10" type="ORF">ERS852478_00136</name>
        <name evidence="11" type="ORF">GT712_00780</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379976.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000078.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44691">
        <property type="protein sequence ID" value="CUN44691"/>
        <property type="gene ID" value="ERS852478_00136"/>
    </dbReference>
    <dbReference type="GeneID" id="66495888"/>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN44691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS87659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="337" mass="37948" checksum="9C3ECF6408681567" modified="2016-09-07" version="1">MLFEKTYGIDLGSSSVKVYSFFRNKTYIEKNMIASKGHTIIAMGNEAYDMFEKSPTDITVTSPMTFGMIANLELQEIVLYSMIRKIDHILGFGATMYFTVPLDMTAVEKRAYFHVANGHWLKKNRVFMVEAPIADAIAMGVNLEDPEGNMIVNIGAQSTEVSIITGGKIIISRKIPLGGRQMNESVCSEIRKRYNLQIGTRTAKRLKMVMGRLSDPKKEVRKVVGIDCISGLPREEIISSYVVNDGIMNCLNEIAAEMKTFLERIPPQISYHIAKQGIYITGGSTRLPYIDKYLASYTGFTFNLSDFYETSAVTGLEKIIRNKELREWAVPVTQRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WZ82</accession>
    <name>A0A173WZ82_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplU</name>
        <name evidence="10" type="ORF">BWLFYP14_02595</name>
        <name evidence="6" type="ORF">ERS852478_00097</name>
        <name evidence="7" type="ORF">ERS852523_01893</name>
        <name evidence="9" type="ORF">GT712_00980</name>
        <name evidence="8" type="ORF">GT728_02960</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP52213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000005">
        <property type="protein sequence ID" value="MZL32179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993901.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000020_gene129"/>
    <dbReference type="EnsemblBacteria" id="CUN43625">
        <property type="protein sequence ID" value="CUN43625"/>
        <property type="gene ID" value="ERS852478_00097"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP52213">
        <property type="protein sequence ID" value="CUP52213"/>
        <property type="gene ID" value="ERS852523_01893"/>
    </dbReference>
    <dbReference type="GeneID" id="66495928"/>
    <dbReference type="eggNOG" id="COG0261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN43625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP52213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL32179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS87698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX66223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="101" mass="11059" checksum="7EBF05233AE41164" modified="2016-09-07" version="1">MYAIIATGGKQYKVAEGDVIRVEKLGVEAGETVTFDNVIAVSNDGLKAGEDVKDASVTATVVENGKAKKVIVYKYKRKTGYHKKNGHRQQYTKVKIEKING</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X5G3</accession>
    <name>A0A173X5G3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cryptic beta-glucoside bgl operon antiterminator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">PRD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bglG</name>
        <name evidence="2" type="ORF">ERS852478_00221</name>
        <name evidence="3" type="ORF">GT728_05885</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46941">
        <property type="protein sequence ID" value="CUN46941"/>
        <property type="gene ID" value="ERS852478_00221"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.24.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004341">
        <property type="entry name" value="CAT_RNA-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="CAT_RNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011608">
        <property type="entry name" value="PRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036634">
        <property type="entry name" value="PRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03123">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01061">
        <property type="entry name" value="CAT_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50151">
        <property type="entry name" value="SSF50151"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF63520"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="67"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="PRD" evidence="1">
        <location>
            <begin position="173"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN46941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="277" mass="31505" checksum="9E9AA6ED8C6F5F46" modified="2016-09-07" version="1">MYRVSKVLNNNGVIAIDMDENKEYVILGKGVGFGKKVSQRFDKPEGCTTYRLEQETERGSAKELVKGIEPEYLEIADAILTESQKVFGDSIDRGILFPLADHISFAVARIRRNEQISNPLTEDIKVLFYSEFKVAETLKTILRERLQIEIDDHEVGYVALHIHSAIGDEKVSVAMQTARAVRECIDMLEKATGKPIDVLSLSYNRLMNHMKYMVARASTGEKLNLDMNEYMLDQYPQAYKVATDICKNLEECIGHKLDETETGYLAMHIQRVYKDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X685</accession>
    <name>A0A173X685_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uma2 family endonuclease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in cyanobacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00228</name>
        <name evidence="4" type="ORF">GT712_00325</name>
        <name evidence="3" type="ORF">GT728_05850</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN47124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703326.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN47124">
        <property type="protein sequence ID" value="CUN47124"/>
        <property type="gene ID" value="ERS852478_00228"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN47124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS87572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="185" mass="21460" checksum="0B10FD6A10115C30" modified="2016-09-07" version="1">MPLLEEEYRKEEKINGVIYDMSPSPNYQHGLVDGNIYRIISTGLQGTLCLAFMENLDYKYHAQENNDYVIPDVMIICDRKHLKGGSYTGTPRFIVETLSPATALRDMTVKKEIYQAAGVEEYWIISPKERAVQIYYLEDGKYDLKYSYILQDDPEEEHYNADTVVTLKDFPKISMTLAEMFENVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XG80</accession>
    <name>A0A173XG80_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199551.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50026">
        <property type="protein sequence ID" value="CUN50026"/>
        <property type="gene ID" value="ERS852478_00290"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4684">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN50026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="211" mass="22222" checksum="7CDFA1E2EA771AA8" modified="2016-09-07" version="1">MNTTTTTTTAAAKRSSTLYMVELAMMIAIILLMSFTPLGYLRTPGLSITLLTIPVAVGAIILGPKGGAVCGLAFGATSFYMAVTGSSAFAAALFNINPFGTFIVCIVARVLEGWLTGLIFAALYKSPAKKFSYYIASLACPLLNTFFFMGFLCLFFYNTDYIQGIVSSLGVSNPVVFVAAFVGVQGLIEAGFCFVVGSIVSKALSVALKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XGX5</accession>
    <name>A0A173XGX5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50550">
        <property type="protein sequence ID" value="CUN50550"/>
        <property type="gene ID" value="ERS852478_00307"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026989">
        <property type="entry name" value="TnpV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14198">
        <property type="entry name" value="TnpV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN50550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="71" mass="8292" checksum="1D14AAB2E8F17193" modified="2016-09-07" version="1">MNLLINGRLNSYLADINQQAEDMFFRLVEQMAEREGVTEQLKANNQMKWGARMNTIQSRATEIVNQDIIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XHE5</accession>
    <name>A0A173XHE5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ilvH_1</name>
        <name evidence="14" type="synonym">ilvH_3</name>
        <name evidence="12" type="synonym">ilvN</name>
        <name evidence="14" type="ORF">BWLFYP14_01941</name>
        <name evidence="10" type="ORF">ERS852478_00322</name>
        <name evidence="11" type="ORF">ERS852523_03655</name>
        <name evidence="13" type="ORF">GT712_05800</name>
        <name evidence="12" type="ORF">GT728_20365</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">2789STDY5834863</strain>
            <strain evidence="11 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 19">BIOML-A1</strain>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000059">
        <property type="protein sequence ID" value="CUQ02442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000100">
        <property type="protein sequence ID" value="MZL35457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000009">
        <property type="protein sequence ID" value="MZS88612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381366.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000100.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000008_gene2689"/>
    <dbReference type="EnsemblBacteria" id="CUN51043">
        <property type="protein sequence ID" value="CUN51043"/>
        <property type="gene ID" value="ERS852478_00322"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ02442">
        <property type="protein sequence ID" value="CUQ02442"/>
        <property type="gene ID" value="ERS852523_03655"/>
    </dbReference>
    <dbReference type="GeneID" id="66495955"/>
    <dbReference type="eggNOG" id="COG0440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN51043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUQ02442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL35457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS88612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX65308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="169" mass="19303" checksum="A163A3DAC219DE29" modified="2016-09-07" version="1">MDKGMKKRWISLYVENQVGVLSKISGLFSGKSYNLDSLTVGTTEDPTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSKEDKVELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIESISMMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XP51</accession>
    <name>A0A173XP51_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-L-fucosidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Alpha-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_01993</name>
        <name evidence="2" type="ORF">ERS852478_00374</name>
        <name evidence="3" type="ORF">GT712_06045</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000009">
        <property type="protein sequence ID" value="MZS88660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706707.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000095.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52657">
        <property type="protein sequence ID" value="CUN52657"/>
        <property type="gene ID" value="ERS852478_00374"/>
    </dbReference>
    <dbReference type="GeneID" id="66496004"/>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN52657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS88660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="474" mass="54278" checksum="3D631484F0CDA66F" modified="2016-09-07" version="1">MPTDQELIKIVPSSRQLAYQATEFYAFFHFGMNTYTNREWGDGTETPQIFNPTEFVADQWVSAAQNAGMKGVILTCKHHDGFCLWPTRYTSHSVVSSPWKNGRGDVVWEVSEACRRYGMKFGIYLSPWDRNKPCYGSGKEYDDYYLAQLTELLTGYGDIFSVWLDGACGEGPNGKKQIYDWKRYYECVRKYQPDACICVCGPDIRWCGNEAGDVRKSEWSVVPARTALAESVQERSQQTDDKEFRMRRITSDMEDLGSRRALEGETNLIWYPAEVNTSIRPGWFYHPEEDDQVKSLEELIYIYIGAVGGNATFLLNIPPMPNGLLHENDVKRLEEFGSWKKKSFTHNLMSTAHIFSENEDPTHPVSDLTDDTSETWFQPESSELPVEITICLDGSYNLGYLVLKEAVCYSQRVEKFEIFVKEGEIWNSIYTGTVIGYKKIISVKGQKAQKVKIVLHDFRVLPLLSFVGIYPESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XP87</accession>
    <name>A0A173XP87_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjO</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Putative multiple-sugar transport system permease YteP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjO_2</name>
        <name evidence="8" type="synonym">ycjO_7</name>
        <name evidence="11" type="synonym">yteP_1</name>
        <name evidence="11" type="ORF">BWLFYP14_01997</name>
        <name evidence="7" type="ORF">ERS852478_00378</name>
        <name evidence="8" type="ORF">ERS852523_01567</name>
        <name evidence="10" type="ORF">GT712_06060</name>
        <name evidence="9" type="ORF">GT728_06440</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000013">
        <property type="protein sequence ID" value="CUP42133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000011">
        <property type="protein sequence ID" value="MZL32849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000009">
        <property type="protein sequence ID" value="MZS88662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706704.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000060_gene472"/>
    <dbReference type="EnsemblBacteria" id="CUN52766">
        <property type="protein sequence ID" value="CUN52766"/>
        <property type="gene ID" value="ERS852478_00378"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP42133">
        <property type="protein sequence ID" value="CUP42133"/>
        <property type="gene ID" value="ERS852523_01567"/>
    </dbReference>
    <dbReference type="GeneID" id="66496008"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="89"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN52766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP42133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL32849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS88662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX65406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="312" mass="35213" checksum="CF142A38834F459D" modified="2016-09-07" version="1">MKTVQNQAKPVSKQTWRNKVTYVKKNWQLYLFFLMPGLLLTIIFKYLPMGGLLIAFEDYNVIKGVLGSPWVGLEYFRRFLSSPDFMNYLMNTLKLSIYGLLWGFPVPIILALLMNRIQKTGIKKKVQLLIYMPNFISVIVLCGMVRMLLSPVGPLNRLLGISTNWMTMPSAFRTIYIASGIWQTAGWASIMYTAALSNASKELEEAAVMDGANLLQQIWYVELPAIKNIIVIQFILQAGNIMSIGFEKAYALQTDMNLPASEILSTYVYRIGLLNGDYGYSTAVGLFNSVVNVILLIFVNWVVKKLNDGEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XXB5</accession>
    <name>A0A173XXB5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized HTH-type transcriptional regulator ydfH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ydfH_1</name>
        <name evidence="5" type="ORF">ERS852478_00464</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199647.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56249">
        <property type="protein sequence ID" value="CUN56249"/>
        <property type="gene ID" value="ERS852478_00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN56249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="218" mass="25541" checksum="C80A3A7C60FD958B" modified="2016-09-07" version="1">MKKETLKQHAYNIIKDKIINCEYAPSALLNEEMLKEDVQASRTPIRDALGRLEQEGLVTILPKKGIMVAPLTIREINMVHEARTLIEPFSILHYGNKISDEIYQNYFRIFQRDTTNVSDLNEYYETDKQFHQMFIDATGNDYLISTYERIAQQNTRLRIYSGRKSRNRLLASQQEHLKIVEYCLKQDWTLASKAMEEHLYHSKEASFEAAFHADSMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XYU1</accession>
    <name>A0A173XYU1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molybdenum cofactor biosynthesis protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">moaA_1</name>
        <name evidence="6" type="ORF">ERS852478_00493</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199675.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57212">
        <property type="protein sequence ID" value="CUN57212"/>
        <property type="gene ID" value="ERS852478_00493"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1964">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034474">
        <property type="entry name" value="Methyltransferase_Class_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43306">
        <property type="entry name" value="PTHR43306"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01100">
        <property type="entry name" value="methyltransferase_(Class_D)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="85"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN57212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="441" mass="49672" checksum="676F36A9038B7505" modified="2016-09-07" version="1">MITIGKTKSVCPECMKVVPAKKCIGEDGIYLVKECNVHGKFQTLIWEGNAADYLSWGRENLSAEIPVNPKIKEKSCPDNCGLCEEHERKGCCMILEVTKRCNMHCPVCFASAGEGGEKGNLPICEIEKQYDFLMAHGGPFNIQLSGGEPTMRDDLPDIIHMGREKGFTFFQLNTNGIRLAREDGYARKLKKAGLNTVFLQFDGVTDQVYETLRGQAMMELKKKAVLNCSEAELGIALVPVIAPGVNDMQVGDILKFGLDHMPFVRGVHFQPISYFGRCSQKRPTNPITIPKMLRLIEEQTEGLMKIEDFAGGGAENPYCSFHASYLRKGERELKLLEKKSGKGCCCTTSDDSRQYVENQWSYSTKNYDEGEMTQTDALDEFLTRIHNETFAVSGMIFQDAWNLDLDRLKRCYICEVDPDYGMVPFCAYNLTNLKGTYLYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XZK1</accession>
    <name>A0A173XZK1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative glutamate synthase (NADPH) small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_00489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199672.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57069">
        <property type="protein sequence ID" value="CUN57069"/>
        <property type="gene ID" value="ERS852478_00489"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="354"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN57069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="764" mass="86170" checksum="0406E2DA52D1BD62" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y823</accession>
    <name>A0A173Y823_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">arcA</name>
        <name evidence="8" type="ORF">ERS852478_00563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199709.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59377">
        <property type="protein sequence ID" value="CUN59377"/>
        <property type="gene ID" value="ERS852478_00563"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="130"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN59377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="238" mass="27470" checksum="E5FA1BE76FE279B2" modified="2016-09-07" version="1">MRIAIVDDISEERTLLRNRLESQFSRRNVHVDIFEYENGETFLTAAKECPFTVVFLDIYMNGSNGIDTAKELRRSDTDCLLVFTTTSTDHALEGFQVRALHYLVKPYSENDISVLADEILSRIPDSGKYIDVKVNGSNIQIPFRKIIYAEHFSHMIHIHTAGERELVTRQSFDSFITSLKMDSRFYRCNRGVVINLEHAVDFDGSGFRLDNGSNVPVSRKLLKNARQTFMEFLFQRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YAY9</accession>
    <name>A0A173YAY9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199715.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60316">
        <property type="protein sequence ID" value="CUN60316"/>
        <property type="gene ID" value="ERS852478_00591"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5401">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016050" evidence="1">
        <location>
            <begin position="28"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="2">
        <location>
            <begin position="64"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="2">
        <location>
            <begin position="205"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN60316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="313" mass="35514" checksum="38C452B4E62BC004" modified="2016-09-07" version="1">MKKKLSIIITALILSILMAGCSVEVHEDPGKQDAKYYLYDISPDETQLQKESYSPEETTADYMLKDMMQRMNSQQTDSQNRISLLPEGVQMNYSIEEDVLVVNFNSQYSSMSRARELLVRAGVVKTFLQVPGINSVRFTIENEDLTDSRGQAVGNMTADTFAEFTGTEPDAYCSNTFTLYFTDKSGQKLVKEQRTVRYKRSIPKERIVLEQLMKGPLEKGHYPTIPENAEVLDVTIADRICYVAFDGVFSSYALDVSEKIPVYSVVNSLLDALDADKVQITVGGKDRLDTFGEKMELYHFYEKNDKLVVKEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YDJ2</accession>
    <name>A0A173YDJ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chondroitin polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kfoC_1</name>
        <name evidence="2" type="ORF">ERS852478_00627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199723.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61600">
        <property type="protein sequence ID" value="CUN61600"/>
        <property type="gene ID" value="ERS852478_00627"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="283"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="542"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN61600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="814" mass="93873" checksum="737DD671DA2CA980" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YTZ3</accession>
    <name>A0A173YTZ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Cysteine synthase</fullName>
            <ecNumber evidence="5 11">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cysK1</name>
        <name evidence="13" type="ORF">ERS852478_00757</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5 11"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706459.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67040">
        <property type="protein sequence ID" value="CUN67040"/>
        <property type="gene ID" value="ERS852478_00757"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="11"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="9">
        <location>
            <begin position="181"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN67040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="309" mass="32746" checksum="6521F463CC4AFBE0" modified="2016-09-07" version="1">MAKIYKNAAELVGNTPLLEVGNLEKELGLEARILVKLEYFNPAGSAKDRIALSMIEDAEERGVLKPGAVIIEPTSGNTGIGLASLAAIKGYRVILTMPETMSVERRNILKAYGAEIVLTDGTKGMNGAIAKANELAKEYENSFIPGQFDNPANPAIHKRTTGPEIWRDTDGQVDVFVAGVGTGGTITGVGEYLKSQNPDVKVVAVEPATSPVLSQGKSGPHKIQGIGAGFVPKALNTEVYDEVFPVENEDAFTVGKLIAKHEGILVGISSGAALYAAIQLAKRPENKGKTIVALLPDSGDRYYSTPLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YV31</accession>
    <name>A0A173YV31_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Inner membrane protein YgaZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ygaZ</name>
        <name evidence="9" type="ORF">ERS852478_00751</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AzlC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199787.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66825">
        <property type="protein sequence ID" value="CUN66825"/>
        <property type="gene ID" value="ERS852478_00751"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011606">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34979">
        <property type="entry name" value="PTHR34979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03591">
        <property type="entry name" value="AzlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN66825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="241" mass="25901" checksum="36CB92F3E7430F10" modified="2016-09-07" version="1">MRSESFRKGVKDGIPIGLGYFAVSFTFGMMAVADGLSIWQAVLISLTNVTSAGQFAGLEIMVMSGSYWEMALTQLIINLRYCLMSFSLAQKFRRDESLVHRYIAAFGVTDEIFGISASQPGKVSAFYNYGAMCVAIPGWVLGTLAGAISGNLLPNFMMSALSVAIYGMFLAIIIPPAKQNKAVLAVVVAAMLISTLFKVIPFLSEVSSGFVIIITTLIVAGAAAYFCPIEDEKEEEGVHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZAQ7</accession>
    <name>A0A173ZAQ7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpC_1</name>
        <name evidence="6 12" type="synonym">atpC</name>
        <name evidence="13" type="ORF">BWLFYP14_01283</name>
        <name evidence="10" type="ORF">ERS852478_00910</name>
        <name evidence="11" type="ORF">ERS852523_01113</name>
        <name evidence="12" type="ORF">GT712_08190</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">2789STDY5834863</strain>
            <strain evidence="11 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000009">
        <property type="protein sequence ID" value="CUP28202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS89049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706997.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000124_gene3946"/>
    <dbReference type="EnsemblBacteria" id="CUN72883">
        <property type="protein sequence ID" value="CUN72883"/>
        <property type="gene ID" value="ERS852478_00910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP28202">
        <property type="protein sequence ID" value="CUP28202"/>
        <property type="gene ID" value="ERS852523_01113"/>
    </dbReference>
    <dbReference type="GeneID" id="66493026"/>
    <dbReference type="eggNOG" id="COG0355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036794">
        <property type="entry name" value="ATP_F1_dsu/esu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020547">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00401">
        <property type="entry name" value="ATP-synt_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46604">
        <property type="entry name" value="SSF46604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6 7" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="9">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_DE" evidence="8">
        <location>
            <begin position="88"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN72883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP28202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS89049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX64199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="137" mass="15405" checksum="BA04368143D1DCC3" modified="2016-09-07" version="1">MADTFGLEIYASNKLAFAGRAKTLTIPAVDGEQAFLAQHENIVAAIIPGEMRFEEADGTKHVLAVSSGFVEMINNRVKLFCLTAESPEEIDIRRAQEAKERAEEQMRQKQSIQEYHMNQLALSRAMARLRVTSHKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZC91</accession>
    <name>A0A173ZC91_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">atpE_1</name>
        <name evidence="13 17" type="synonym">atpE</name>
        <name evidence="19" type="ORF">BWLFYP14_01289</name>
        <name evidence="15" type="ORF">ERS852478_00916</name>
        <name evidence="16" type="ORF">ERS852523_01119</name>
        <name evidence="18" type="ORF">GT712_08220</name>
        <name evidence="17" type="ORF">GT728_01265</name>
    </gene>
    <organism evidence="15 20">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 20 21" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 20">2789STDY5834863</strain>
            <strain evidence="16 21">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="17 23 24" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 24">BIOML-A1</strain>
            <strain evidence="18 23">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="19 22" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000009">
        <property type="protein sequence ID" value="CUP28379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS89055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707007.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000124_gene3952"/>
    <dbReference type="EnsemblBacteria" id="CUN73066">
        <property type="protein sequence ID" value="CUN73066"/>
        <property type="gene ID" value="ERS852478_00916"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP28379">
        <property type="protein sequence ID" value="CUP28379"/>
        <property type="gene ID" value="ERS852523_01119"/>
    </dbReference>
    <dbReference type="GeneID" id="66493032"/>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUN73066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUP28379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MZL31861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MZS89055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="VUX64211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="72" mass="7070" checksum="2F6A917828011F7A" modified="2016-09-07" version="1">MLVAIGAGIAVLTGIGAGIGIGMATSKAVEAIARQPEAESKISKSLLLGCALAEATAIYGFVIGLLIVIMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZVF9</accession>
    <name>A0A173ZVF9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase subunit P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79609">
        <property type="protein sequence ID" value="CUN79609"/>
        <property type="gene ID" value="ERS852478_01086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025487">
        <property type="entry name" value="DUF4379"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14311">
        <property type="entry name" value="DUF4379"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DUF4379" evidence="1">
        <location>
            <begin position="10"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4379" evidence="1">
        <location>
            <begin position="79"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4379" evidence="1">
        <location>
            <begin position="148"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN79609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="234" mass="26491" checksum="9274C04E87CFF1B2" modified="2016-09-07" version="1">MNNSLAEVHPELVSEWSEKNLPLTPDDITFGSNKKVWWKGTCGHEWQTSVKARLNGEKCPICSGARVIAGINDLATLEPLLVKQWSKKNKIKPTEVSIGSHKKVIWRCKKGHEWEAAVKSRTINKTGCPYCSHNKVLAGFNDFATLLPDIAAEWSDRNYPLLPTQVTVFANRKAWWKCKDCGREWNTLISTRSGGSKCPYCSGYIFSKGFNDLQTTHPEIQKSWLLSQEVPMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZYT2</accession>
    <name>A0A173ZYT2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted metal-binding protein related to the C-terminal domain of SecA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SEC-C domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secA_1</name>
        <name evidence="3" type="ORF">BWLFYP14_03122</name>
        <name evidence="1" type="ORF">ERS852478_01111</name>
        <name evidence="2" type="ORF">GT728_00895</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057400.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80556">
        <property type="protein sequence ID" value="CUN80556"/>
        <property type="gene ID" value="ERS852478_01111"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN80556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL31789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="171" mass="19822" checksum="8D3A9465351811CF" modified="2016-09-07" version="1">MSDKTILEQWRAIAYDQQADRNKLQRFWANYFNIEKGIYEQLLSNPDEVVTGTVKELAEKYGQEVLTMVGFLDGINDSLKIPNPIETMDENTKVSLCFDKELLYKNMVDARADWLYELPQWDEIFTPEKRKELYLEQKKSGTVVKAKKIGRNDPCPCGSGKKYKYCCGKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ABT1</accession>
    <name>A0A174ABT1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006857252.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86071">
        <property type="protein sequence ID" value="CUN86071"/>
        <property type="gene ID" value="ERS852478_01236"/>
    </dbReference>
    <dbReference type="GeneID" id="61431734"/>
    <dbReference type="eggNOG" id="ENOG5032SVB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045721">
        <property type="entry name" value="DUF6075"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19552">
        <property type="entry name" value="DUF6075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN86071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="134" mass="15987" checksum="3089F8FF46A54889" modified="2016-09-07" version="1">MADIKFRDTAHRDFFLENMMKCRVNDCYHRAFFYVMGIASETRANINQMFNFKEDCIEPEGMHGGWQTSGTVKVCHLAFNLWNGYAEEGRERYFTPEELFCCEFAPYFMEGIKVRYPEYCWELPAPRKQTEISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AFW7</accession>
    <name>A0A174AFW7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome-partitioning protein parB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">parB_1</name>
        <name evidence="3" type="ORF">ERS852478_01270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199997.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87287">
        <property type="protein sequence ID" value="CUN87287"/>
        <property type="gene ID" value="ERS852478_01270"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="33"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN87287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="311" mass="36158" checksum="641A74F9D6EF0462" modified="2016-09-07" version="1">MARSRETKIELTAYDDLFQTDESREEAKLSKIRDIPISEIDEFPDHPFKVLMDEDMEQLVESIKRNGVMTPATVRLKEDGRYELISGHRRKKACELAGLETLKCEVKELTRDEAIIVMVESNLQRSVILPSEKAFAYKMRLEAMKRQGERSDLTSSPMGTKLRSDAELAEKVGESRNQIQRYIRLTELVPEILQMVDERQIAFRPAVEVSYLTEEQQYTLLEAMEYNDATPSLAQAIKMKKYNQDGKLTSEVIQSIMEEEKPNQKEKPAFRDERITKLIPKTVPRGQETDFVVKALEFYNRHLQRNKAHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AIM7</accession>
    <name>A0A174AIM7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bacterial regulatory proteins, tetR family</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Probable dihydroxyacetone kinase regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_01624</name>
        <name evidence="3" type="ORF">ERS852478_01282</name>
        <name evidence="4" type="ORF">ERS852523_00874</name>
        <name evidence="5" type="ORF">GT728_08310</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
            <strain evidence="4 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000007">
        <property type="protein sequence ID" value="CUP20306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000015">
        <property type="protein sequence ID" value="MZL33200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380387.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000052_gene882"/>
    <dbReference type="EnsemblBacteria" id="CUN87749">
        <property type="protein sequence ID" value="CUN87749"/>
        <property type="gene ID" value="ERS852478_01282"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20306">
        <property type="protein sequence ID" value="CUP20306"/>
        <property type="gene ID" value="ERS852523_00874"/>
    </dbReference>
    <dbReference type="GeneID" id="66494958"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN87749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP20306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL33200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX64769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="189" mass="22161" checksum="1E0AD52FC2701C3B" modified="2016-09-07" version="1">MPNTTKAALEESLKRLLLKKPLDKITITDITTDCGISRMAFYYHFKDIYDLVEWSCVEDGTKALQGKKTSESWTEGLTQIFEAVLENKPFIMNVYRNVDRERIENYLFKLTYDLIVGVVEEKSKGLNITEEDKKFIADFYKYGFVGIMLEWIREGMKENIEDLVRMMDLTLHDTVTTSIHNFQKNNMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AKP9</accession>
    <name>A0A174AKP9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yehU_3</name>
        <name evidence="10" type="ORF">ERS852478_01293</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200006.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88115">
        <property type="protein sequence ID" value="CUN88115"/>
        <property type="gene ID" value="ERS852478_01293"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="313"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="477"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN88115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="595" mass="68275" checksum="550759D7351517C5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AMU0</accession>
    <name>A0A174AMU0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Competence protein ComM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">comM_1</name>
        <name evidence="4" type="ORF">ERS852478_01314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200045.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88788">
        <property type="protein sequence ID" value="CUN88788"/>
        <property type="gene ID" value="ERS852478_01314"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="213"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN88788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="510" mass="56071" checksum="A27845788623E26D" modified="2016-09-07" version="1">MFASVLSAAIFGVEVCPVQVEADVSNGLPSFIMVGFPSAQVKEAQERVRTALKNNGYQFPPKRITVNFAPADMKKEGAGFDVPVAAAVLAAFEMISPQVVSRVMMAGEIGLDGEIHGISGILPIVLCARSLGSRFCVVPYENLKEGRLIRDVPVAGVKNLQELVECLKNPEPYLTREIQEEIPSIINTDMGMDFSDIEGQEGAKRAAEIAVSGFHNLLLIGPPGTGKTMLARRLPTIMPGLGFEEKLELTRIYSIAGLLSREHPLIDERPFRSPHHTSTPQAIAGGGRNPRPGEITLAHKGVLFLDEMPEFSRASLELLRQPMEDKVIQIARASGTYSFPADFMLCAAMNPCPCGYYPDLNRCTCTAGEITHYMGKISRPLLDRIDISTEVPPVSFAQLHCGRKGENSAAIRKRVEKVQKIQEERYKDEKINFNGQLKSSLIDKFCPLTDSASRLLARAFEKIAFSARSYHRILKVARTIADMEGEEMIAGHHIGEALSYRAFDKDSVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AX52</accession>
    <name>A0A174AX52_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-clamp processivity factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">DNA polymerase III beta sliding clamp subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">DNA polymerase III subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">dnaN_1</name>
        <name evidence="17" type="ORF">ERS852478_01409</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93167">
        <property type="protein sequence ID" value="CUN93167"/>
        <property type="gene ID" value="ERS852478_01409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="14">
        <location>
            <begin position="3"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="15">
        <location>
            <begin position="121"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="16">
        <location>
            <begin position="242"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUN93167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="354" mass="39540" checksum="19EBEF0D2E644ED6" modified="2016-09-07" version="1">MKVQKYEISRTIDKLKSIVQKNDQFPALGGVLVKDGYLTASNTEMTMQLKLEASKGSYFIIPMKAFDVIKNLPDGEVDIDTEGENIVVIKTKAIKNKYQSYPPEDFSFDITENPDASGVVINGKSLMEAIGHVIYAAADSSSSTQMMGVYFEGGENKIKLVALDGHVVAVDSIPTDGTADMKLIVPKTVAKKLVSMGIIDDVAVTYTKNRAVFKSKEYTIYTRLIEGKYFDYNRFFMAGKMKTYVSRLELVAAMTRAKMCTEEKKPAVFEMNEDQLNIRIADRLTDYQEEMKLQDPLPEPLKIGFDSKLVLETLKAFTCENIAMNFSGPKMPAVVEAEDSDMKAIVLPVMIREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AX85</accession>
    <name>A0A174AX85_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200063.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93064">
        <property type="protein sequence ID" value="CUN93064"/>
        <property type="gene ID" value="ERS852478_01406"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN93064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="74" mass="8364" checksum="AC640FAE9DEC1D38" modified="2016-09-07" version="1">MIAMKPVSKTGIVIRYNFVKLEHEYHYCPVCGGALNAGPDYYPDFCEKCGQALDFSGTEWKEDRQIGFVEPEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B0F5</accession>
    <name>A0A174B0F5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01447</name>
        <name evidence="2" type="ORF">ERS852523_01028</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP25260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055150020.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94342">
        <property type="protein sequence ID" value="CUN94342"/>
        <property type="gene ID" value="ERS852478_01447"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP25260">
        <property type="protein sequence ID" value="CUP25260"/>
        <property type="gene ID" value="ERS852523_01028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038628">
        <property type="entry name" value="XkdM-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN94342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP25260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="151" mass="16454" checksum="131B791E0362B0ED" modified="2016-09-07" version="1">MLNTSAATDARHSRSGKDAMLYNADGVPFAQVSSFQSKTSFNNTKYQPLGQNRELETNNTIGVTITISEIVVLDGELFNNVVSAVNKGESPVMTLDGVIEGRNGSQERITYRECIFSGDQDLQNVSTGDTLSRSYNLHCNGEVEPRSSLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B459</accession>
    <name>A0A174B459_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacteriophage peptidoglycan hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95193">
        <property type="protein sequence ID" value="CUN95193"/>
        <property type="gene ID" value="ERS852478_01472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="218"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN95193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="456" mass="51158" checksum="7DD0AD566F5B9BF8" modified="2016-09-07" version="1">MDKQNITVLRKILYAVESGNQIYGEQDYAAFAEVGANCSNEKAITIGAGQWYADEAKELLYRIQRGNPKLFKDMDTENLEADLLKKSWATYAVSKDSAKGRLIISIISMELGKKCQDQYMEDQIAAYAKSIEKTYGSMPDTAMMECINILHQGGFDALKRILSKTPEPYTADKIYATLCRDPADPTPNQVGDYTDRQKTVINMIHTYADNTEKEGIAMTKTEKAIRQMETWAKDDSHGYDQDYRWGEKGDYDCSSAVIQAWQNAGVPVKSGGATYTGDMKNVFLKNGFVDVTSKVNVATGSGLLRGDVLLNEAHHVAMYCGNGKEVEASINEKGTAHGGKPGDQTGKEFLIRSYRNYPWNCVLRYRGNIFSASDTEKKQNTVAYVARFTKDCKCYSAAGKTQAKMFPVIKKNAVVDVMKYTETVKGKRWYFIRIPYPNDEGFVREFVPAGYFKKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B5F0</accession>
    <name>A0A174B5F0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion-translocating oxidoreductase complex subunit E</fullName>
            <ecNumber evidence="7">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Rnf electron transport complex subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nqrD</name>
        <name evidence="7 11" type="synonym">rnfE</name>
        <name evidence="11" type="ORF">BWLFYP14_00985</name>
        <name evidence="8" type="ORF">ERS852478_01493</name>
        <name evidence="10" type="ORF">GT712_13085</name>
        <name evidence="9" type="ORF">GT728_10970</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 15">BIOML-A1</strain>
            <strain evidence="10 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000024">
        <property type="protein sequence ID" value="MZL33705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000026">
        <property type="protein sequence ID" value="MZS89980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380993.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95954">
        <property type="protein sequence ID" value="CUN95954"/>
        <property type="gene ID" value="ERS852478_01493"/>
    </dbReference>
    <dbReference type="GeneID" id="66492609"/>
    <dbReference type="eggNOG" id="COG4660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00478">
        <property type="entry name" value="RsxE_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010968">
        <property type="entry name" value="RnfE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30586:SF0">
        <property type="entry name" value="PTHR30586:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01948">
        <property type="entry name" value="rnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN95954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS89980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX63499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="236" mass="24656" checksum="D4683A530AFC5BE2" modified="2016-09-07" version="1">MKPNTPAERLYNGIIKENPTFVLMLGMCPTLAITTSATNGIGMGLTTTVILAASNLMISLLRNFIPDRVRMPAFIVVVASFVTVVQLLLQGFIPSLYDSLGIYIPLIVVNCIILGRAEAYASKNKPIASLFDGIGMGLGFTLSITCIGAVRELIGAGSLFGHQILPLADATAGKAGYEPITIFILAPGAFFVLAALSALQNKFKIGAAKRGIDPSNPDCGGSCAACGNTMCKGKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B8U5</accession>
    <name>A0A174B8U5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ion-translocating oxidoreductase complex subunit B</fullName>
            <ecNumber evidence="5">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Rnf electron transport complex subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rnfB</name>
        <name evidence="12" type="ORF">BWLFYP14_00983</name>
        <name evidence="9" type="ORF">ERS852478_01495</name>
        <name evidence="11" type="ORF">GT712_13075</name>
        <name evidence="10" type="ORF">GT728_10980</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 16">BIOML-A1</strain>
            <strain evidence="11 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 3 [4Fe-4S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000024">
        <property type="protein sequence ID" value="MZL33707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000026">
        <property type="protein sequence ID" value="MZS89978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380994.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96035">
        <property type="protein sequence ID" value="CUN96035"/>
        <property type="gene ID" value="ERS852478_01495"/>
    </dbReference>
    <dbReference type="GeneID" id="66492607"/>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2878">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
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</entry>
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        <source>
            <dbReference type="Pfam" id="PF18830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN97953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1554" mass="174553" checksum="4679A52F1DF48274" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BHZ1</accession>
    <name>A0A174BHZ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008688092.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00612">
        <property type="protein sequence ID" value="CUO00612"/>
        <property type="gene ID" value="ERS852478_01601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO00612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="79" mass="8807" checksum="E263E641E0676C57" modified="2016-09-07" version="1">MDIKTAVIYRLNDLIKQKDITVNEAAVRSGVPPSTLKNILYGQSRNAGVVTIKKICDGLDITIQEFFEDPIFADLEPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BIF7</accession>
    <name>A0A174BIF7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200152.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99406">
        <property type="protein sequence ID" value="CUN99406"/>
        <property type="gene ID" value="ERS852478_01563"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN99406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="594" mass="66904" checksum="6D1269FEE77B66F3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BIK0</accession>
    <name>A0A174BIK0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008688068.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00343">
        <property type="protein sequence ID" value="CUO00343"/>
        <property type="gene ID" value="ERS852478_01593"/>
    </dbReference>
    <dbReference type="GeneID" id="67479048"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025464">
        <property type="entry name" value="DUF4315"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14193">
        <property type="entry name" value="DUF4315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO00343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="100" mass="11602" checksum="1C609F03BAC765EA" modified="2016-09-07" version="1">MKSLEKATADYEKAKEKMEASKARYEADLKRFKAAEIAKTEAENLEIVRIIRAMDMSIPELEAFKKRMKNELPGRVEIQKEETKADDESGKNETEEENNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BLE3</accession>
    <name>A0A174BLE3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">topB_4</name>
        <name evidence="12" type="ORF">ERS852478_01595</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057309.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00406">
        <property type="protein sequence ID" value="CUO00406"/>
        <property type="gene ID" value="ERS852478_01595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005738">
        <property type="entry name" value="TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01056">
        <property type="entry name" value="topB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO00406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="690" mass="78670" checksum="3AB0B51363247C3A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C4A8</accession>
    <name>A0A174C4A8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit dhaK</fullName>
            <ecNumber evidence="2">2.7.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dhaK</name>
        <name evidence="2" type="ORF">ERS852478_01760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200233.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06720">
        <property type="protein sequence ID" value="CUO06720"/>
        <property type="gene ID" value="ERS852478_01760"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="1">
        <location>
            <begin position="6"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO06720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="315" mass="34603" checksum="6E0F6595CDC843A3" modified="2016-09-07" version="1">MRLWNSRETALNEALNGIKRACPGKYTRLETEYGYGLYRNNISSNRVRIIVDGGGGYGHMWSAFAEEGLADAMVHGNFDSAPNAYVLYEMAKNIDCGKGILFLTNHYMGDYLNNDMAVELLAHDNINAAMCCISDDILSCEGEIAENRGGLHGIGQICKICAGAAREGYNLEQLSKLASKSNSRVRSVSLNVREGKLFFGEGFSGEPAVKEKVFESVDQMFSDAVDILLSELGLWKDCPMYLSVNNHCNVGFTESMVLLESAAKQIEERKIKLCGCAAGTYFDVFDGKGCILSLIACDEEMQKYIAPVNGYGYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C6Q2</accession>
    <name>A0A174C6Q2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glgC_4</name>
        <name evidence="3" type="ORF">ERS852478_01782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057948.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000089.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07386">
        <property type="protein sequence ID" value="CUO07386"/>
        <property type="gene ID" value="ERS852478_01782"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011832">
        <property type="entry name" value="GlgDAde_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523:SF6">
        <property type="entry name" value="PTHR43523:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02092">
        <property type="entry name" value="glgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO07386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="371" mass="41967" checksum="5FC732D7E53A4E8E" modified="2016-09-07" version="1">MYKAFGIVSSSGRNIYVDGMQDYRPIGAFSFLGRYRVIDFPISNMTNSDIDRIQVYINNKPRSVVEHVGTGRHYNINSKSGKLQLLFSEHNNDNDIYNTDISCYLDNMESLSRMYHPYVVIAPSYMVYSIDFDQFLHTHIDSGADVTLLYHAVDNAKEAYLTCNVLGLNRQKGVESIEPNHGNKKNQYVYMDTCVMKTELFISLIKEAKNLSSMYTLTDILNDKCETLDIRGVAHKGFFASITDFPSYYAANMALLNYKSAQELFHENWPIYTRTNDSCPTQYFNTADVKNSVISNGCQIEGTVENSVIGRGCIIKKGAVVRNSVVLAEATVGEGVHVENEVVDKWAKLVHKKEIVSPTEQPGYIRRNDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CHY6</accession>
    <name>A0A174CHY6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">sbcD_2</name>
        <name evidence="9" type="synonym">sbcD</name>
        <name evidence="12" type="ORF">ERS852478_01926</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SbcD family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200442.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12744">
        <property type="protein sequence ID" value="CUO12744"/>
        <property type="gene ID" value="ERS852478_01926"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004593">
        <property type="entry name" value="SbcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026843">
        <property type="entry name" value="SbcD_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12320">
        <property type="entry name" value="SbcD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00619">
        <property type="entry name" value="sbcd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="10">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="SbcD_C" evidence="11">
        <location>
            <begin position="262"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO12744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="378" mass="43606" checksum="E8D502BC3A9F577B" modified="2016-09-07" version="1">MKFGHIGDLHIGKRVHDFSMLEDQRYILDQMIKIFEEQKVDGVLIAGDVYDKTVPSAEAVQLFDEFITGLSKAEIPVYMISGNHDSAERLSFGAKLFESSDIYISQVYDGEMKRIVLEDQYGPISVYLLPFLKPAAVRHALQRDDINTYEEGVMAALQECEIDRTQRNVLVAHQFVTGADRSDSEETWVGGLDNVSAEVFKNFDYAALGHIHRPQKMGRETLRYSGTPLKYSFSEADHKKSVTIVELLEKGNVRVSTVPLIPRRDMRKLRGTYMDVTAKDHYTAENKMDYLQITLTDEEDVPGALQKLRTVYPNLMRLEYDNKRTRENREVQAVEAQEQKSELELFEEFYELLNNEPMKEEQTEFVEKLIQNLKEVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CUU0</accession>
    <name>A0A174CUU0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200494.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16797">
        <property type="protein sequence ID" value="CUO16797"/>
        <property type="gene ID" value="ERS852478_02033"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO16797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="106" mass="12090" checksum="1ED3F3ADC3BCE7CF" modified="2016-09-07" version="1">MYDTEKRIELVKKRMYEYHRRQERRTVRRLSVLCTLLFLSLVGAMGIMQSRPINATGMYGTILLHEGAGGYVLVAVISFTVAVVITALCIKFRNRGQKSQDAEDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CUW2</accession>
    <name>A0A174CUW2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uridine kinase</fullName>
            <ecNumber evidence="3">2.7.1.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">udk</name>
        <name evidence="3" type="ORF">ERS852478_02049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.48" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200516.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17271">
        <property type="protein sequence ID" value="CUO17271"/>
        <property type="gene ID" value="ERS852478_02049"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="289"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO17271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="555" mass="63465" checksum="65581D89677CE312" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D349</accession>
    <name>A0A174D349_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Predicted hydrolase of the alpha/beta superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_02364</name>
        <name evidence="1" type="ORF">ERS852478_02081</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO18286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18286">
        <property type="protein sequence ID" value="CUO18286"/>
        <property type="gene ID" value="ERS852478_02081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO18286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX65994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="224" mass="24849" checksum="EEEDC3C6BD3D124A" modified="2016-09-07" version="1">MTSLTIEQKRVDIYPSAKPGSPVIYLNTFSNAVNSVYKNLMALGCPDFCLVAVSNLKWDHDMTPWYMGPISKHDTPCTGGADDYLKLLLDEIMPEAEALLPGAPAWRGLAGYSLAGLFALYALYQTDVFARAASMSGSFWFEGIMEYVCSHEMKRKPDCLYFSLGDKESSTDNPILNVVQQNTQEIETLCHGKGIETTFVLNSGSHYQACNKRTAAGIHWILNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D5Q5</accession>
    <name>A0A174D5Q5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005334885.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20961">
        <property type="protein sequence ID" value="CUO20961"/>
        <property type="gene ID" value="ERS852478_02146"/>
    </dbReference>
    <dbReference type="GeneID" id="43514232"/>
    <dbReference type="GeneID" id="64114161"/>
    <dbReference type="GeneID" id="66495340"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO20961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="137" mass="15706" checksum="5F4EC2ECEFD00EA8" modified="2016-09-07" version="1">MIRKRTIIIVITILLLLAGILFYLQWGRQMDVSSSSGSGSDNHYELRVSVILNTLVVTDQQKCAEQIFEKCRDNSFHSVRFSYDIQIPHALSVTVYKNQKDAESGNSAFSFSYRQENQIDGTYNIVDNPEKFTLEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DBY6</accession>
    <name>A0A174DBY6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA binding domain, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21558">
        <property type="protein sequence ID" value="CUO21558"/>
        <property type="gene ID" value="ERS852478_02165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO21558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="66" mass="7502" checksum="7FEE4A3D7509FCA4" modified="2016-09-07" version="1">MISDTSNTETPKKEKKTYTVEEIAEQLCVSKKVAYALVKSGQFAYVRAGRAIRVSKDSFDKWLNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DC12</accession>
    <name>A0A174DC12_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Haloalkane dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379903.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21859">
        <property type="protein sequence ID" value="CUO21859"/>
        <property type="gene ID" value="ERS852478_02175"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019908" evidence="1">
        <location>
            <begin position="33"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="65"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO21859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="317" mass="35977" checksum="4C0729D863829009" modified="2016-09-07" version="1">MSKNKHKFFTFAALMTGATVAVHFINHTIATAAQLKQMLHISNDNYFEWRFGNIYYTKKGTGSPILLIHDTLPGASGYEWNKIEDELAIDHTVYTVDLLGCGRSDKSSITYTNFVYVQMISDFIKKIIGQKTDVITSGFSGSFVTMACHNEKELFNKIMLVNPPSLTQLKQMPNRKDRLLKAALEIPIFGTLVYHMIVSRDNINNLFIEKMYYNPFHVDNQMSDAYYEAAHKGGYYTRFLYSSLAAKYMNVNICHALKALDNSIYIVEGETEPNGKAVTDDYCASNPAIEVSVLKETKHLPHVEAPEAFLEQVKIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DJ42</accession>
    <name>A0A174DJ42_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DegV domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DegV domain-containing protein SAV1425</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_01492</name>
        <name evidence="2" type="ORF">ERS852478_02239</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705503.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24359">
        <property type="protein sequence ID" value="CUO24359"/>
        <property type="gene ID" value="ERS852478_02239"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO24359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX64639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="279" mass="30874" checksum="80D3C62CC03AC711" modified="2016-09-07" version="1">MRYKIIIDSCGELLDEWKKDECFESIPLTLMVGAEQIIDDETFDQAEFINKVAACPECPKSACPSPERYMRAYDCEAEHIYAVTLSSELSGSYNSALLGRDLIMEDHPDKKIHVFNSRSASIGESLIGMKIQECEEAGMSFEEVVSTVEHYIEGQHTFFILENLDTLRKNGRLSKVKALVASALKIKPVMGSTDDGNICQLDQARGMNRALIKLVEQVIEKTPDSAEKVLAISHCNCPARAQVLKEAFEERMKLAKIVVLDTAGVSSMYANDGGVIVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DJ56</accession>
    <name>A0A174DJ56_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pyrE</name>
        <name evidence="6" type="ORF">ERS852478_02232</name>
        <name evidence="7" type="ORF">GT728_09340</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000018">
        <property type="protein sequence ID" value="MZL33396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705489.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24175">
        <property type="protein sequence ID" value="CUO24175"/>
        <property type="gene ID" value="ERS852478_02232"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="44"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="128"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO24175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="226" mass="25274" checksum="8A1A6AB6E45397A9" modified="2016-09-07" version="1">MEQYKQEFIEFMVDSEVLKFGEFTLKSGRKSPFFMNAGGYVTGSQLKKLGEYYAHAIHDKYGDDFDVLFGPAYKGIPLSVVTAIAFSELYGKEIRYCSDRKEEKDHGADKGSFLGSKLKDGDRVVMIEDVTTSGKSMEETVPKVKGAADVEIVGLMVSLDRMEVGKGGVKCALDEVHDLYGFETNAIVTMREVIEHLYNKEYKGKVIIDDTLKAAIDAYYEQYGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DWW7</accession>
    <name>A0A174DWW7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">ffh</name>
        <name evidence="9" type="ORF">ERS852478_02362</name>
        <name evidence="10" type="ORF">GT728_07925</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000014">
        <property type="protein sequence ID" value="MZL33134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704686.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28769">
        <property type="protein sequence ID" value="CUO28769"/>
        <property type="gene ID" value="ERS852478_02362"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
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        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
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        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="191"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="249"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO28769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL33134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="451" mass="49096" checksum="5306F96600205568" modified="2016-09-07" version="1">MAFESLTDKLQNVFKKLRSKGRLTEEDVKLALKEVKMALLEADVNFKVVKQFTKSVQEQAIGQDVMSGLNPGQMVIKIVNDELVKLMGSETTDLPLRPGNEITVFMMAGLQGAGKTTTVAKLAGKLKSKGKKPLLVACDVYRPAAITQLQVNGEKQGVEVFSMGDKQKPVDIAKAAIEHAKANQQNVVLIDTAGRLHVDEDMMQELADIKANIQVDATILIVDAMTGQDAVNVASTFADKVGIDGVILTKMDGDTRGGAALSIKAVTGKPILYVGMGEKLSDLEQFYPERMASRILGMGDVMSLIEKAEASIDKEQAQDMQKKLKKMDFDFNDYLTSMEQMNKMGGIGSILNMLPGMGGKMKDIEGMIDEKAMDRTKSIILSMTPQERSNPSILNISRKNRIARGAGVDVSEVNRLVKQFEQSKKMMKQMPGLMGGKAGKRGGGFKLPFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E083</accession>
    <name>A0A174E083_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ion channel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_02384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29490">
        <property type="protein sequence ID" value="CUO29490"/>
        <property type="gene ID" value="ERS852478_02384"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO29490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="424" mass="46009" checksum="5275B244D67F9A0F" modified="2016-09-07" version="1">MNNTKSSKNVSLKNQLELWLFCALIGAVAGALVWILLKIMAVGTEFLWKWLPGKTSFPYYTILICVAGAAIIGIFRKIFGDYPEDLETVMGKVRTEKRYEYKNMLVMMVAALLPLLIGSSVGPEAGLTGIIVGLCYWAGDNLKFAKQNTRNYSQIGAAVSMSVLFHAPLFGIFEVEENSEEDLAALTKGSRLFIYGIALAAGTGIYAGLSALFGAGLSGFPSFDMVEIQRKDYLLMILYILCGLILAYFYQATHKLTGNISNRFPAVVREIFAGLCLGIAGSFLPALMFSGEEQMGTLMKTYTSYLPLALIGIAFFKLLLTNLCIQFGLKGGHFFPVIFAGVCMGYGVAMLTCGPDGGHVVFGAAIVTASLLGGIMKKPLAVTMLLFLCFPVKMFIWIFIAAAVGSKLITLKPEQEPSANYSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E1T2</accession>
    <name>A0A174E1T2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">kdpD</name>
        <name evidence="12" type="synonym">kdpD_1</name>
        <name evidence="12" type="ORF">BWLFYP14_00122</name>
        <name evidence="10" type="ORF">ERS852478_02414</name>
        <name evidence="11" type="ORF">GT712_04385</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053412.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30409">
        <property type="protein sequence ID" value="CUO30409"/>
        <property type="gene ID" value="ERS852478_02414"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="300"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO30409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS88349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX66569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="521" mass="58344" checksum="777160A617F1E3F5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E2M9</accession>
    <name>A0A174E2M9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">xerD_4</name>
        <name evidence="6" type="ORF">ERS852478_02451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32041">
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        <property type="gene ID" value="ERS852478_02451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
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        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="128"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO32041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="325" mass="37213" checksum="A329EEF79B121A59" modified="2016-09-07" version="1">MQKFDPLKKYSFRKARDWKYPLWCSLAVNAYLDWLRRSFHSEGTIRSYKYVVYNFCDFLLLKKLSSFEDLNRNLINEFLRIDLHSTVNGTSGRNSVLRQFITFLEDNNYLADQTIHGVIPAKLAHHRKIITILSDEQISCINEYRKTCNSPIELRDAAMVMIGLKLGFRSSNVINLKLSDIDWMNKKISITQYKTKVSISLPLSVDVGNAVFRYMKYGRPECDDPHVFVRHKAPYGILSGKICSNALNRVLSTVSDGSSVKFHTLRKTFATSILKNNAGVERVIDALGNRDSTTVNVYLTYDELHMRKCALSLKEMSIPMGGATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E3W1</accession>
    <name>A0A174E3W1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative rRNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_00098</name>
        <name evidence="1" type="ORF">ERS852478_02438</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO31129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704818.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31129">
        <property type="protein sequence ID" value="CUO31129"/>
        <property type="gene ID" value="ERS852478_02438"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010719">
        <property type="entry name" value="rRNA_methylase"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35276">
        <property type="entry name" value="PTHR35276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06962">
        <property type="entry name" value="rRNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO31129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX66545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="187" mass="20787" checksum="E67DB5CF4611C748" modified="2016-09-07" version="1">MKNYQITQWCAAFIRQQVQEGDFCIDATMGNGNDTLLLSQLCGESGKVLAFDIQEQALTATQKRLNAGHVPENYRLLLESHANMAEYATPDSVSCIVFNFGYLPGGDHSLATRGKTSIQALTQALTLLKKGGMISLCIYSGGDSGFEERDQILDWLKNLDPHQYLVIKSEYYNRPNNPPIPVLIIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E9L6</accession>
    <name>A0A174E9L6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Elongation factor Ts</fullName>
            <shortName evidence="6">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">tsf</name>
        <name evidence="10" type="ORF">ERS852478_02494</name>
        <name evidence="11" type="ORF">GT712_02385</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703687.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33159">
        <property type="protein sequence ID" value="CUO33159"/>
        <property type="gene ID" value="ERS852478_02494"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF_TS" evidence="9">
        <location>
            <begin position="72"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="6">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO33159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS87970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="312" mass="34047" checksum="DB51CEB084014645" modified="2016-09-07" version="1">MAITAAQVKELREMTGAGMMDCKKALTATEGDMDKAVEFLREKGLATAQKKASRVAAEGLCKTLVSEDGKKAVVVEVNAETDFVAKNEKFQNYVADVAAQAMNTTAADIDAFLAEAWALDTTKTVKEALAAQIAVIGENMNIRRFAQVTEENGFVASYTHMGGKIGVLVDVETDVVNDAVKEMAKNVAMQIAALKPQYTSDSEVSAEYIEHEKEILMAQIQNDPKESQKPAKVIEGMITGRIKKELKEICLLDQTYVKAEDGKQSVAKYVEQVAKENGAKITVKGFVRYETGDGIEKKEENFAEEVAKQMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EBY0</accession>
    <name>A0A174EBY0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillinase repressor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Regulatory protein BlaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">blaI_5</name>
        <name evidence="3" type="synonym">blaI_4</name>
        <name evidence="3" type="ORF">BWLFYP14_02424</name>
        <name evidence="2" type="ORF">ERS852478_02555</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000050">
        <property type="protein sequence ID" value="VUX66052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005426520.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000069.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35294">
        <property type="protein sequence ID" value="CUO35294"/>
        <property type="gene ID" value="ERS852478_02555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO35294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="123" mass="14439" checksum="523EE0710EEA543A" modified="2016-09-07" version="1">MSLPQISEAEFEVMKIVWKYAPINTNEITEKLTLTTSWSPKTIQTLIKRLVSKKALSYEKQSRVFVYTPLVQEDEYIRQESNSFLKRYYNGNLSSMLASYLEDDKLSSTEIDNLRHLLSKHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EC97</accession>
    <name>A0A174EC97_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02560</name>
        <name evidence="2" type="ORF">GT712_19000</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000067">
        <property type="protein sequence ID" value="MZS91068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703846.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000067.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35444">
        <property type="protein sequence ID" value="CUO35444"/>
        <property type="gene ID" value="ERS852478_02560"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032XC6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025468">
        <property type="entry name" value="TTRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041965">
        <property type="entry name" value="TTRAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14203">
        <property type="entry name" value="TTRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO35444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS91068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="81" mass="9317" checksum="888FDE85BA4ED15A" modified="2016-09-07" version="1">MMNLAMNFDTDECSVTAMFDKGNRNDTMEAIDHIIPFLKGDADMIVLVCNTLRKLFCMSDEGYETFLMDLEDYKSELEEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EGV3</accession>
    <name>A0A174EGV3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Magnesium/cobalt efflux protein CorC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ytfL</name>
        <name evidence="11" type="ORF">ERS852478_02612</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0053 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36931">
        <property type="protein sequence ID" value="CUO36931"/>
        <property type="gene ID" value="ERS852478_02612"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="216"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="286"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO36931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="437" mass="49350" checksum="B1E5B1A27BB98E13" modified="2016-09-07" version="1">MEDGSSMPLWGLFVLLLLLWLNGIFYGFAAALRNISENDTQKKAEEGDKKAQMLMTLIDKPAQFVNAIPLIVMACGICFGTFLVPYVVDVFYPYIKHVPALILVMALCVIFLAAIGILAFRRVGTYHPEAYAYKYLNLVHFWLNLLKPFTVSVTWIARLAAVPFGVEINRTEKSVTEEEIISIVDEAHEQGVIQENEAEMIQNIISFNETEAHDIMTHRKNVVAFDEEILLKNMIDTMLEEGNSRYPVYEENIDNIKGIVHYKDALKFMTQNPWAKFKPLKELPGIIRQASLIPETRGIGDLFHTMQARKIHMAIVVDEYGQTAGIVTMEDILEEIVGDILDEYDEDEITIRAQKDNSLIIDGLAYLEDVEEELDVDFGDTEFETLNGYLTNILGHIPADKDVDTSIKAIGYCFTILSIGNKTIGKVKVERDNNVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EQX3</accession>
    <name>A0A174EQX3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Beta-galactosidase</fullName>
            <shortName evidence="5">Beta-gal</shortName>
            <ecNumber evidence="3 5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">bglY</name>
        <name evidence="11" type="ORF">ERS852478_02667</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 42 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 5"/>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO39006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200821.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39006">
        <property type="protein sequence ID" value="CUO39006"/>
        <property type="gene ID" value="ERS852478_02667"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003476">
        <property type="entry name" value="Glyco_hydro_42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36447">
        <property type="entry name" value="PTHR36447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001084">
        <property type="entry name" value="B-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="9">
        <location>
            <begin position="13"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42M" evidence="10">
        <location>
            <begin position="396"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO39006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="674" mass="76961" checksum="5225A4A074211C3E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZ75</accession>
    <name>A0A174EZ75_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized ATPase YjoB</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjoB</name>
        <name evidence="2" type="ORF">ERS852478_02741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200877.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41340">
        <property type="protein sequence ID" value="CUO41340"/>
        <property type="gene ID" value="ERS852478_02741"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="32"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO41340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="516" mass="58663" checksum="890D0B20D2183EE4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F1D8</accession>
    <name>A0A174F1D8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydrogen peroxide-inducible genes activator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Morphology and auto-aggregation control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">oxyR</name>
        <name evidence="5" type="ORF">BWLFYP14_01045</name>
        <name evidence="3" type="ORF">ERS852478_02802</name>
        <name evidence="4" type="ORF">GT728_08470</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000016">
        <property type="protein sequence ID" value="MZL33228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380974.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43367">
        <property type="protein sequence ID" value="CUO43367"/>
        <property type="gene ID" value="ERS852478_02802"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO43367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX63678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="311" mass="35102" checksum="EFCB179204ACDA81" modified="2016-09-07" version="1">MTLTQMNYIITISETGSLNKAAEALYISQPSLTNAVKELEKELGIIIFNRSGRGVTLTNDGTEFLMYARQIYGQYESVVEKYSEGGSYKKKFGVSTQHYSFAVKAFVDMVQKFDVSEYEFAIRETKTADVISDVSTMKSEVGVLYLSDFNRKALLKLLHSANLEFHHLIDCQAYVYLWKNHPLANEKSISYSQLAKYPCLSFEQGDKSSFYLSEEILSTNEYSRTVKASDRATMLNLMVGLNGYTLCSGIICEELNGSDYLAIPFEGDEQNQNSDMEIGYITRKNSILSKVGNLYVSSLKKYLEQNTVSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F1Y5</accession>
    <name>A0A174F1Y5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate transport system permease protein CysT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysW_1</name>
        <name evidence="11" type="ORF">ERS852478_02814</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200949.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43711">
        <property type="protein sequence ID" value="CUO43711"/>
        <property type="gene ID" value="ERS852478_02814"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011865">
        <property type="entry name" value="CysT_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406:SF8">
        <property type="entry name" value="PTHR30406:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02139">
        <property type="entry name" value="permease_CysT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="59"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO43711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="278" mass="29976" checksum="3B253F825BC83B62" modified="2016-09-07" version="1">MKKRNKPVIPGFGLSMGITISILSLVVLIPLASLVVYTAKLSFKDFIETITRARVLASFYTSFVCAFAAAVINGIMGTILAWVLVKYDFPGKRLMDGVIELPFALPTAVAGIALTSLTSDSGIVGSFFAGFGIKIAYTRIGITVAMIFVGIPFVVRSVQSVLEKMDNSYSEAAGVLGAKKTTIFWKVIFPELKPAIFAGIGLAFGRCLGEYGSVVFIAGNKPYYTEITPLVIMSKLQEFDYSSATAIALVMLAVSFFILFLNSMIQQRNARILRGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F3J1</accession>
    <name>A0A174F3J1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol-3-phosphate transporter periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02845</name>
        <name evidence="3" type="ORF">ERS852523_03601</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000056">
        <property type="protein sequence ID" value="CUQ00874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379915.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44803">
        <property type="protein sequence ID" value="CUO44803"/>
        <property type="gene ID" value="ERS852478_02845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ00874">
        <property type="protein sequence ID" value="CUQ00874"/>
        <property type="gene ID" value="ERS852523_03601"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014251230" evidence="1">
        <location>
            <begin position="26"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO44803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ00874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="443" mass="48332" checksum="5551657D8ABBF2BF" modified="2016-09-07" version="1">MKRKLAVLLTAATVFSAILPTTCMAAEKKADIPEGTTISFWHAMGGVNGEALDYLVNKFNEENEYGIKVDSQYQGEYDDEINKLKSAQLGNMGADLVQIYDIGTRFMIDSGWVIPMQDMIDSEGYDVSDLEPNITAYYTVDDKLYSMPFNSSTPILYYNKDMFDKAGVTEVPTSLEGIAEVADDLVNKGGAGEALSMGIYGWFFEEFMCKQGLPYVDNGNGREAAATKVAFDENGGALNILNEWKKLYDAGYAPNVGRGGDSGLADFSSGKAAMTLGSTASLKQILQDVNGSFEVGTAYFPSITDDDKGGVSIGGASLWMLDNQDDAKKAATWEFVKYLVSAESQAYWNAQTGYFPVTTAAHDEQVFKDNIAKYPQFQTAIDQLHDSAPEYAGALLSVFPEARAIVETEIENMLNGKESAEDAVSKMASDMNKSIEDYNLLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F6B8</accession>
    <name>A0A174F6B8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysN</name>
        <name evidence="8" type="ORF">ERS852478_02820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070102132.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43890">
        <property type="protein sequence ID" value="CUO43890"/>
        <property type="gene ID" value="ERS852478_02820"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2895">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="2"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO43890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="546" mass="60441" checksum="7497EE4A6B1FB991" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F7Y0</accession>
    <name>A0A174F7Y0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">MEP cytidylyltransferase</fullName>
            <shortName evidence="7">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ispD</name>
        <name evidence="8" type="ORF">ERS852478_02830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200951.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44430">
        <property type="protein sequence ID" value="CUO44430"/>
        <property type="gene ID" value="ERS852478_02830"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO44430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="230" mass="25942" checksum="F6F24EBCE31A85AE" modified="2016-09-07" version="1">MSERNTAIVLAAGQGKRMHSKVQKQFLEIQGYPVLYYSLRCFQESPLIQDIILVTGEESISYCKEEIVKKYGFTKVSAVIPGGKERYDSVYAGLCECRDCEYVLIHDGARPFVTEEILKRGLQKVKETGACVIGMPSKDTVKLSDEEGYVKETPNRKCVWTIQTPQIFLYSLIREAHDSIRQKDMSKITDDAMVVEQETGAKVALAEGSYQNIKITTPEDLDIAEAFLKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FAB8</accession>
    <name>A0A174FAB8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_02875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058545.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45609">
        <property type="protein sequence ID" value="CUO45609"/>
        <property type="gene ID" value="ERS852478_02875"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="417"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO45609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="517" mass="61104" checksum="E806FC5A6D6E8309" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FE11</accession>
    <name>A0A174FE11_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aminopeptidase YwaD</fullName>
            <ecNumber evidence="8 11">3.4.11.6</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Arginyl aminopeptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">M20/M25/M40 family metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ywaD</name>
        <name evidence="11" type="ORF">BWLFYP14_03589</name>
        <name evidence="8" type="ORF">ERS852478_02961</name>
        <name evidence="10" type="ORF">GT712_01820</name>
        <name evidence="9" type="ORF">GT728_07345</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 15">BIOML-A1</strain>
            <strain evidence="10 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.11.6" evidence="8 11"/>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000013">
        <property type="protein sequence ID" value="MZL33020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201029.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48394">
        <property type="protein sequence ID" value="CUO48394"/>
        <property type="gene ID" value="ERS852478_02961"/>
    </dbReference>
    <dbReference type="GeneID" id="66493662"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039866">
        <property type="entry name" value="CPQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053">
        <property type="entry name" value="PTHR12053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="7">
        <location>
            <begin position="215"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO48394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS87861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX67314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="426" mass="47404" checksum="E00BBBAAF4F912B0" modified="2016-09-07" version="1">MNTNEISGKRQMEFLAEFDYIREAGTVGEEKAATIIQETLNSFGVENHLEEFCFETFQVKKAKLTITEPYAKEYIVTGYGRCANTDENGRNESFLYVENADEISLANARGKIVMVNDPVRKELYQKLVKAGVAGFISIAGSPLDEGVDLTPRAYSLPKNLPGEEKKAAGIEAANYDNRIPGVSIHYKDAVELVTRGAAKACLSVEQETVTRTSRNVVARIKGTDKAEEILTLTAHYDSVPEGPGAYDNMSGAAIIMELCRYFKEHRPRRTMEFVWFGAEEKGLLGSRNYIKEHETELPAHRFNMNVDLAGQLVGGTVVGVTGDASICNMITYMAHETGIGMSTKNQIWGSDSNTFAWKGIPAMTLNRDGFGMHTRHDTIALLSDWSLERSAILLGHIADRLGNIEIFPFERKVPEEFIRQLDEYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FJS1</accession>
    <name>A0A174FJS1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="2 3">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">murF</name>
        <name evidence="6" type="ORF">ERS852478_03024</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="2 3"/>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053789.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50494">
        <property type="protein sequence ID" value="CUO50494"/>
        <property type="gene ID" value="ERS852478_03024"/>
    </dbReference>
    <dbReference type="GeneID" id="66495462"/>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 3" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="5">
        <location>
            <begin position="110"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="4">
        <location>
            <begin position="318"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="112"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO50494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="456" mass="50344" checksum="13DC9914053E4571" modified="2016-09-07" version="1">MKNLTLENIARVCGGTYYGPADKLQEEVMSVITDSRKAEEGCLFVPIVGERVDAHKFIPQVMEAGALATLSERVLDNADFPYIAVESSLQAVKDIAEFYLKQLQIPVVGITGSVGKTSTKEVIASVLNQKYHTLKTQGNFNNELGLPLTVFRLRDGDEIAVLEMGISDFGEMTRLAQIARPDTCVITNIGTCHLENLGDRNGVLKAKTEIFKFLRPEGHIVLNGDDDKLITVKEYEKIKPVFFGMSNECQVYGDKIVSRGLKGMTCTIHLGDTAFTVDIPMPGRHMVYNALAAAAVGNIYGLTTEQIKAGIESLEPISGRFRMIETDKFLIVDDCYNANPMSMKASLDVLQDGAGRRIAVLGDMGELGENEVQLHEEVGEHAGKCDIDVLICTGKLCRNMAERAQRTNPDLKVIYEPDRESLLEHLEGYVQDGDTILVKASHFMKFEEVVTKLENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FJV5</accession>
    <name>A0A174FJV5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50524">
        <property type="protein sequence ID" value="CUO50524"/>
        <property type="gene ID" value="ERS852478_03025"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033QM6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO50524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="198" mass="23238" checksum="2C746F99B5EC8EE5" modified="2016-09-07" version="1">MLEKVMELHFLLYAMMLMGGLGALGMLTTHLTYRRMIRKNTEVKSNLKEKWTNLWKTRDRLLNRMNRFVWYPSLFCIAFLGLAFFLYSKDARWDGMPLAYLYVAAIIPTALLLLRQALDFTYREELLMNSFSDYVEHARTWVEEVPVPEKADEAVKEEIVEHIADSIRQTAAAGSHFSGMLTPEEDEIMREIIREFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FPJ0</accession>
    <name>A0A174FPJ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO52123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52123">
        <property type="protein sequence ID" value="CUO52123"/>
        <property type="gene ID" value="ERS852478_03069"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Recombinase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO52123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="386" mass="44654" checksum="52262E05EA009865" modified="2016-09-07" version="1">MLNICIVFAQLERETIQKRVSDAYYSRSQKGFRMGGKPPYGYRLEEILMEGIHTKKLVEEPGEAAIVREIFDMYEQPDTSYGDITRYYAEKGVQFYGKELIRSMLAQLLRNPVYVRADMDVYRFFRSHGTNIVSSPEQFDGIHGCYLYQGRDAQTDKLQNLKGHMLVVAPHEGLVSSEQWLNCRIKLMRNKTIQANRKAVNTWLAGKVKCGNCGYALMSIKIQSGKQYLRCTKRLNNKACPGCGKVYTEDVENYVYKEMVRKLREGQSPATYTKLNENPQVKQIYREIEEMEKEISLLVDSLAGAGETLTDYINQRVEEIDQMHQLKLEKLSVLAENHATPEQMEKVASNISLWGEIDFEEKRFTVDKMIRSLKVFPGLVQIQWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FRM8</accession>
    <name>A0A174FRM8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator sinR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sinR_2</name>
        <name evidence="2" type="ORF">ERS852478_03088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO52894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201135.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52894">
        <property type="protein sequence ID" value="CUO52894"/>
        <property type="gene ID" value="ERS852478_03088"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041511">
        <property type="entry name" value="DBD_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18430">
        <property type="entry name" value="DBD_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO52894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="119" mass="13455" checksum="28C12B4B2FAEBA2C" modified="2016-09-07" version="1">MKQDKVKYDFKAFGQAIKAARKAKGISRNQLADTLNIAPRYIASIENSGQHPSLQILYELVTLLDVSVDQFFFPEREQEKSTRRRQLDTMLDTMSETDLKIMSATAKGIEEANNDRTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G6E4</accession>
    <name>A0A174G6E4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase YbjI</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybjI_2</name>
        <name evidence="1" type="ORF">ERS852478_03226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381376.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57551">
        <property type="protein sequence ID" value="CUO57551"/>
        <property type="gene ID" value="ERS852478_03226"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO57551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="264" mass="29526" checksum="8DE7076DD5A6D8B3" modified="2016-09-07" version="1">MIKLIASDIDGTLVKDGTLAIDREYMEVIGRLIDKGIVFVACSGRQYRSERKLFTPVADRLLYISDGGTVVRTPKEILKVDTLPDEIWKGMCSMVRENMPSCDYFISTPERCFAEDGGSQMFHWLRDSYGYDIHEVPEMLKLEGQQVNKFAVYHPNACEEMCAPLFTPTWKDKTVMAAAGKEWMDCTAPGSGKGPSVAFLQEYLGISPDETCTFGDNLNDIEMLQNAGLSYAVSNSRPEVRAAAKNTCPPYWENGVLQILKSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G8U7</accession>
    <name>A0A174G8U7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sigM_4</name>
        <name evidence="6" type="synonym">ylaC_2</name>
        <name evidence="6" type="ORF">BWLFYP14_03486</name>
        <name evidence="4" type="ORF">ERS852478_03269</name>
        <name evidence="5" type="ORF">GT712_16855</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO58803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000046">
        <property type="protein sequence ID" value="MZS90682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381006.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58803">
        <property type="protein sequence ID" value="CUO58803"/>
        <property type="gene ID" value="ERS852478_03269"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO58803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX67211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="169" mass="20372" checksum="BE04760B2BC50804" modified="2016-09-07" version="1">MEKSEIETIYRKYFHDVFLYIRALSENESLAEEITQETFLKAMNNIEKFDGRKDIRAWLFVIAKNTYFRYCRRNKIYVGEEFSEIMQDPMQDTSPAVLDQIVQDETVRNLKRYAELIPEPYREVFHLRIYGELSFEQIGKCYQKSAGWARVTYHRARQMIRAQISQEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GCT4</accession>
    <name>A0A174GCT4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper export regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional regulator CueR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">MerR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cueR_2</name>
        <name evidence="5" type="ORF">BWLFYP14_03490</name>
        <name evidence="3" type="ORF">ERS852478_03273</name>
        <name evidence="4" type="ORF">GT712_16875</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO58896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000046">
        <property type="protein sequence ID" value="MZS90686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060018.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58896">
        <property type="protein sequence ID" value="CUO58896"/>
        <property type="gene ID" value="ERS852478_03273"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO58896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX67215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="213" mass="24556" checksum="83F4CFAC8D3A48A1" modified="2016-09-07" version="1">MKIKQVEELVGITRKNIRFYEEQGLLNVERAENGYREYHTADIARLQEIKLFRKMDISIEEMRALFEKRKSLQFCLEQHLGELERRREGLVKMQEMCERLIAEHQSLDTLNAENCLEEIEQMEKEGARFMDIKKTDIRKKRRTGAIIGAVVMILLMGFTIGLMLWANTQDPIPTGLLIFLIAIPVVIIGGILAALAGRMKEIEGGEEDEASKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GHC8</accession>
    <name>A0A174GHC8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201327.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61974">
        <property type="protein sequence ID" value="CUO61974"/>
        <property type="gene ID" value="ERS852478_03364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO61974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="196" mass="22751" checksum="FF565EAE00730690" modified="2016-09-07" version="1">MIVNKCSENLLKKSKKLYENYRDNCTVVQRMLEKYKKIYPNISDYSIMHFIDIAEFCDLIMDRQKLEDLNGDECYCLLMAALFAHTGFGLNQEIMNKYINKLGIQKQTQSLTFLQIMSKYHVLFSACLIEEYGDIFEFPSEKHKYAITSMLYFIGGNSDDINQLEEILVLDNKNTVRLKDLAAVLVVGNQLAELKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GLG5</accession>
    <name>A0A174GLG5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpsU</name>
        <name evidence="11" type="ORF">BWLFYP14_02944</name>
        <name evidence="7" type="ORF">ERS852478_03409</name>
        <name evidence="8" type="ORF">ERS852523_01089</name>
        <name evidence="10" type="ORF">GT712_13890</name>
        <name evidence="9" type="ORF">GT728_07770</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP26892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000014">
        <property type="protein sequence ID" value="MZL33103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000029">
        <property type="protein sequence ID" value="MZS90135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000072">
        <property type="protein sequence ID" value="VUX66668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004222305.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1050"/>
    <dbReference type="EnsemblBacteria" id="CUO63462">
        <property type="protein sequence ID" value="CUO63462"/>
        <property type="gene ID" value="ERS852478_03409"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26892">
        <property type="protein sequence ID" value="CUP26892"/>
        <property type="gene ID" value="ERS852523_01089"/>
    </dbReference>
    <dbReference type="GeneID" id="61849545"/>
    <dbReference type="GeneID" id="67481657"/>
    <dbReference type="eggNOG" id="COG0828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018278">
        <property type="entry name" value="Ribosomal_S21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01181">
        <property type="entry name" value="RIBOSOMAL_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO63462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP26892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS90135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX66668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="58" mass="6948" checksum="15B6073BE2D0D114" modified="2016-09-07" version="1">MSNVIVKENETLDSALRRFKRSCAKAGIQQEIRKREHYEKPSVRRKKKSEAARKRKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GRN9</accession>
    <name>A0A174GRN9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02939</name>
        <name evidence="2" type="ORF">ERS852478_03415</name>
        <name evidence="3" type="ORF">GT712_13865</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000029">
        <property type="protein sequence ID" value="MZS90130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000072">
        <property type="protein sequence ID" value="VUX66663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059418.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63590">
        <property type="protein sequence ID" value="CUO63590"/>
        <property type="gene ID" value="ERS852478_03415"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50348MK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO63590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="61" mass="7208" checksum="76C5BC8780028F12" modified="2016-09-07" version="1">MGSESEEKKEMLIINGNAFYEIDLECVKKKKQCAQTVHPEKKTDRINSRNMKDKDNIRQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GRQ8</accession>
    <name>A0A174GRQ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201400.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63610">
        <property type="protein sequence ID" value="CUO63610"/>
        <property type="gene ID" value="ERS852478_03416"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50324I6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO63610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="121" mass="13584" checksum="FD196389734C1073" modified="2016-09-07" version="1">MNEEQISQTLLDQMVSSDRGQMIKAAIPYLPPKGQQIFSVYEKAVEFINTVSVFSKRSSGSDLCAMSMPAQNPVDIVNDIRSFCYGPSRDKLDQMVNMMAMVQMLQLMNQPADGEKEDSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GW48</accession>
    <name>A0A174GW48_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Biotin synthase</fullName>
            <ecNumber evidence="3 13">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">bioB_2</name>
        <name evidence="13" type="synonym">bioB</name>
        <name evidence="16" type="ORF">ERS852478_03458</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13 14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3 13"/>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201410.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65069">
        <property type="protein sequence ID" value="CUO65069"/>
        <property type="gene ID" value="ERS852478_03458"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 13 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 13" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="44"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUO65069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="330" mass="36882" checksum="58E907889057FE92" modified="2016-09-07" version="1">MNPLILAQEIIDGRRITREDDLSFFLTCDLDELCEGADRIREAYIGDKVDLCSIINGRSGRCPEDCKYCAQSIHHHTSCEIYDFLPEEKILEACKMNEEEGVDRFSIVTAGKALTGKEFDQAIHAYETMYKECNIDLCASMGFLSSEQLHRLHEAGVTSYHHNIETSRRNFPNICTTHTYDMKIETLKKVKAEGMCACSGGIIGMGETWEDRLDMAVSLAELGIDSIPINALMPIPGTPLEHLDQLSEQDILRTIAFFRYINPEANIRLAAGRALLTNDGETAFKSGASATITGNMLTTVACATIRSDRKMLSDMGRNVTPEYWKEVEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GXT4</accession>
    <name>A0A174GXT4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cssS_2</name>
        <name evidence="10" type="ORF">ERS852478_03542</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004844683.1">
        <property type="nucleotide sequence ID" value="NZ_WWVM01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67552">
        <property type="protein sequence ID" value="CUO67552"/>
        <property type="gene ID" value="ERS852478_03542"/>
    </dbReference>
    <dbReference type="GeneID" id="57435255"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="179"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO67552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="392" mass="45679" checksum="354C548C1937E13A" modified="2016-09-07" version="1">MEKIRNLSLKKTILLYFVISLTAAFLLSGFTVHFARNMQNKIWEKYIDYADYTDVFQQYGKKYEIEISRPNQSQMNRLDYHLSEMCDFMETYSVLIFSIVGSVAAVFFFYKNKLKTPLQELKDASQMIADNELDFHVSYENKDEMGTLCKEFEMMRSALADNNRKMWRMIDDEKALRNAIAHDIRSPLSILRGYQEMLLEFVSAESIKTEDVIDILQTGMYQIDRIEHFTENMRKMSHLEQRELQCSEIELSELAKKIEAEAAMLSKKESKLCKVERVQEQNIVKVDEELVMEVTDNLLENAVRYAQKSIALQIKKKDGFLIISVEDDGIGFVDTEEKVTEPFYHKNPQDDLKHFGLGMYISRIFCEKHGGNLKIYNARQGGAHVEALFKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H2J9</accession>
    <name>A0A174H2J9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FtsX-like permease family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_03589</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201453.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69073">
        <property type="protein sequence ID" value="CUO69073"/>
        <property type="gene ID" value="ERS852478_03589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="574"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO69073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="676" mass="75018" checksum="A45984BDAFF6E7B6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H682</accession>
    <name>A0A174H682_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposon Tn7 transposition protein tnsC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tnsC</name>
        <name evidence="2" type="ORF">ERS852478_03576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68519">
        <property type="protein sequence ID" value="CUO68519"/>
        <property type="gene ID" value="ERS852478_03576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008868">
        <property type="entry name" value="TniB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05621">
        <property type="entry name" value="TniB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO68519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="429" mass="48430" checksum="DF8115A40AAD0ADA" modified="2016-09-07" version="1">MNEIIKLIPEMKTGQELMECMGEYPDYLPEVREKSSAERLIALSDIYDIYIPSQMSVEIYHKLYMGLMRSLQKKSSIQAVHQQYENCKGVRGRKYQGGILGGSDSFSIIGASGIGKSSTVFRAVRLITEKEVIEMETPYLKIAPCIVVQCPFDSSVKGLLWEILRKVDEVLGSRYYHNAVRARATTDMLIGNVSQVALQHIGLLVVDEIQNVVNSRNGKQLVGMLTQLINNSGISICMVGTPESIVFFEQAMQLARRSLGLQYEAMEFDKDFIVICKVLWGYLYTKSGVTLTDGIIEWLYEHSGGNISILVALIHDAQEISILEGRDVLDMTALEQAYQKRMAMLHDYLEPSVRRKKQTSAKKKKELITEMEDMGNQEKTGRTGDSDSVRMDMDGQEISLEELVADAKVRNLNIVEIFQKHFAVEEVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HAG7</accession>
    <name>A0A174HAG7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conjugative transposon protein TcpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO71904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201491.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71904">
        <property type="protein sequence ID" value="CUO71904"/>
        <property type="gene ID" value="ERS852478_03681"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8HY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16428">
        <property type="entry name" value="TcpC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024735">
        <property type="entry name" value="TcpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035628">
        <property type="entry name" value="TcpC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12642">
        <property type="entry name" value="TpcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="303" mass="34199" checksum="D8CFCE45753D18E0" modified="2016-09-07" version="1">MFKKNKKQTETIKEPKEKKVRTVKVGTHKKTVIALWVVLIASVSFGVYKNFTAIDQHTTHEKEIIELRLQDTNGIENFVKNFAKSYYTWNNSKEAIEARTQAINGYLTKELQDLNVDTIRTDIPTSSTVTNVIVWSIEQSGTDTFSATYEVDQQIKEGEQTSNVKATYTVKVHVDADGDMVIVQNPTLAPAIEKSDYEPKTPEADASVDADAVNDATSFLETFFKLYPTATEKELAYYVSGNVLEPIGRDYFYSELVNPIFIKDGDNVKVKVAVKFLDNQTKATQVSQYELVLHKDSNWKIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HBF9</accession>
    <name>A0A174HBF9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6430 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03676</name>
        <name evidence="4" type="ORF">GT712_06805</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000010">
        <property type="protein sequence ID" value="MZS88786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201487.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000072.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71611">
        <property type="protein sequence ID" value="CUO71611"/>
        <property type="gene ID" value="ERS852478_03676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045535">
        <property type="entry name" value="DUF6430"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20016">
        <property type="entry name" value="DUF6430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6430" evidence="2">
        <location>
            <begin position="85"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO71611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="297" mass="33980" checksum="B8D251CA82A050B0" modified="2016-09-07" version="1">MNKVNVIKQNLEFIGKTWIKYIGTFASILSLFFLFWTWDDIRITSTQYKCVIIILLCVLALILAILWTCIFKRTKTIWESPSGKIKVCYSDIMKDGFDKRNKEEKLFVIPVNSCFDTIVDEDISTCSKPLVSPNSLHGRWIKTMVNKGFTIEEIDNKIHNCLEMQNLVPKSIIADEDKERGKREVYELGTVAMIRGNNNSTFLLLAISEYDKDNIAHTSVDDLEMCIKSLLNFYDQHGQGHRLVIPLMGTNLSRAGLSHNDSLRVITSLFQLYGDKIHGEVDVVIYKGDKDKVTLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HCE5</accession>
    <name>A0A174HCE5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Dihydropteroate synthase</fullName>
            <shortName evidence="8">DHPS</shortName>
            <ecNumber evidence="4 8">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">folP</name>
        <name evidence="10" type="ORF">ERS852478_03648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DHPS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="4 8"/>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381441.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPF010000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70830">
        <property type="protein sequence ID" value="CUO70830"/>
        <property type="gene ID" value="ERS852478_03648"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="9">
        <location>
            <begin position="14"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO70830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="269" mass="29658" checksum="A8B90488C8905CB4" modified="2016-09-07" version="1">MKIGNRFFDTKNHTYIMGILNVTPDSFSDGGKWNHMDEALKHTEAMIADGADIIDIGGESTRPGHTPVSADEEAQRVLPVIEAVKKHFDIPVSVDTFKSSVAESSIQAGADLVNDIWGLKYDPKMAAVIAKYDVACCLMHNKSNTEYQNFVIDMLAETQECVNLARQAGIKDEKIMLDPGIGFGKTFEMNLEAMNHLELFQNLGFPVLLGTSRKSMIGLALDLPVDQRVEGTLATSVIGVMKGCSFVRVHDVKENKRVIQMTEAILGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HL45</accession>
    <name>A0A174HL45_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">H(+)/Cl(-) exchange transporter ClcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">clcA</name>
        <name evidence="6" type="ORF">ERS852478_03754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000047">
        <property type="protein sequence ID" value="CUO73878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201509.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73878">
        <property type="protein sequence ID" value="CUO73878"/>
        <property type="gene ID" value="ERS852478_03754"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
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        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO73878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="444" mass="47894" checksum="E14A9712E0DD0C51" modified="2016-09-07" version="1">MEKEEKRADQENDTEEQSTEAKSLLKKKLQYYSSEIQRDVGNLVKWLMIAVLVGCITGAASTLFSFVLKSVTNCRKENEWMFYLLPVMGLIIVYLYEKFGKDDGGTNQVLSTVRSQDDVPILSAPLIFISTALTHLAGGSAGREGAAIQLGGSIANQLGRWIHLDEEDRHVIVMCGMSAAFSALFGTPMAAAVFALEVVSVGVMYYTALMPCMIASLVASGFAAGMGVTPETFHVVDIPKLTIETGLKMGAIAVGCAVISIVFCMVLNGVAGVYGRWFKNPYVRVVVGSCLVIGITLLLGTSDYMGAGAELIEKAVEEGQARPLDFFWKLVLTALTMRAGFRGGEIVPSFCIGATLGCVMGNWLGFSPSICAACGMTAVFCGVTNCPITSILIAFEMFGFKGVPFYLIAVSISYAASGYYGLYKDQTIVYSKYKAKYVNKPTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HMT3</accession>
    <name>A0A174HMT3_9FIRM</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03777</name>
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    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000049">
        <property type="protein sequence ID" value="CUO74587.1"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CUO74587">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000095431">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO74587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="137" mass="15497" checksum="6E85C6B7ECA5524A" modified="2016-09-07" version="1">MKNNSYDDIINLPHPVSKNHPQMPLRDRAAQFAPFAALTGHDAAIKETARLTDERLELSEEVIAQLNEKINIIRNNIGIEQKVSITYFIPDAKKAGGSYVTCSGIVKKIDEYEHTMIMTDQTVIPIEQISDIKCEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HN97</accession>
    <name>A0A174HN97_9FIRM</name>
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        <submittedName>
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    <gene>
        <name evidence="2" type="ORF">ERS852478_03830</name>
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    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000056">
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76384">
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        <property type="gene ID" value="ERS852478_03830"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO76384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="140" mass="16444" checksum="70A82400C71BFF73" modified="2016-09-07" version="1">MNQDERRFDFHGLGLALKQAREEKGWTQAYVAELVGKTDRTIMNIENKGQRPSFNLFFKLVTLFDISVYQFFYTEGQRGENSCRKHIDVLLSSMNEKELVVMEATAEGLKKARETEVQEVWLFCVSSMYWWKQSKHGLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J7N1</accession>
    <name>A0A174J7N1_9FIRM</name>
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        <submittedName>
            <fullName evidence="4">DUF448 domain-containing protein</fullName>
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        <submittedName>
            <fullName evidence="3">Protein of uncharacterized function (DUF448)</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="5" type="ORF">GT712_10180</name>
        <name evidence="4" type="ORF">GT728_08805</name>
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    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
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    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO95633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000018">
        <property type="protein sequence ID" value="MZS89425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707588.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2222"/>
    <dbReference type="EnsemblBacteria" id="CUO16572">
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        <property type="gene ID" value="ERS852478_02025"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95633">
        <property type="protein sequence ID" value="CUO95633"/>
        <property type="gene ID" value="ERS852523_00056"/>
    </dbReference>
    <dbReference type="GeneID" id="66495645"/>
    <dbReference type="eggNOG" id="COG2740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
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    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF448"/>
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        <property type="entry name" value="YlxR"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO16572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO95633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX62372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="91" mass="10543" checksum="F654C58A5D1D334A" modified="2016-09-07" version="1">MKTKNKIPMRQCTGCREMKSKKEMLRVLKTTEDEIVLDTTGKKNGRGAYLCLSRECLDKAIKNHGLERSLKTAVPDEVYERLKKELEDIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JY01</accession>
    <name>A0A174JY01_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-responsive transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02706</name>
        <name evidence="1" type="ORF">ERS852478_00210</name>
        <name evidence="2" type="ORF">ERS852523_00367</name>
        <name evidence="3" type="ORF">GT712_00410</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
            <strain evidence="2 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000003">
        <property type="protein sequence ID" value="CUP04654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703296.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000025_gene947"/>
    <dbReference type="EnsemblBacteria" id="CUN46648">
        <property type="protein sequence ID" value="CUN46648"/>
        <property type="gene ID" value="ERS852478_00210"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04654">
        <property type="protein sequence ID" value="CUP04654"/>
        <property type="gene ID" value="ERS852523_00367"/>
    </dbReference>
    <dbReference type="GeneID" id="66495814"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN46648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP04654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS87589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="135" mass="15459" checksum="86AAC238CAC5C3E4" modified="2016-09-07" version="1">MFITRECDYAVRVVRALWGESRLSVSDICEKEAITAPFAYKILKKLQKAEIVKGYRGVHGGYSLNRGLDELTLYEVYSAIDPDMFIIECLDPKYNCVRDGQDGLPCLVHRELLSVQDELISLLKRKTIQQIMEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K164</accession>
    <name>A0A174K164_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Undecaprenyl-diphosphatase BcrC</fullName>
            <ecNumber evidence="4">3.6.1.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bcrC</name>
        <name evidence="5" type="ORF">BWLFYP14_02738</name>
        <name evidence="3" type="ORF">ERS852478_00242</name>
        <name evidence="4" type="ORF">ERS852523_00421</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.27" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN47518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000003">
        <property type="protein sequence ID" value="CUP05853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703344.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000017_gene262"/>
    <dbReference type="EnsemblBacteria" id="CUN47518">
        <property type="protein sequence ID" value="CUN47518"/>
        <property type="gene ID" value="ERS852478_00242"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05853">
        <property type="protein sequence ID" value="CUP05853"/>
        <property type="gene ID" value="ERS852523_00421"/>
    </dbReference>
    <dbReference type="GeneID" id="66495780"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="57"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN47518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP05853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="180" mass="19985" checksum="29F5B87822F680E9" modified="2016-09-07" version="1">MATLQQLDMNILLWIQEHLRVDALTPFWRAVTFLGNGGWFWIVLCVLLICFGKTRKTGVTAALSLLSGFLITNLLIKNAVARPRPFDTYTQIIPLITRPKDYSFPSGHTCASFAVALVCLRMLPGKWGILPVVLAGMIAFSRLYLGVHYPGDVLAGFLVALLTSTVACRLMRRTFSPQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NAK3</accession>
    <name>A0A174NAK3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Meso-diaminopimelate D-dehydrogenase</fullName>
            <shortName evidence="10">DAPDH</shortName>
            <shortName evidence="10">Meso-DAP dehydrogenase</shortName>
            <ecNumber evidence="5 10">1.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ddh</name>
        <name evidence="16" type="ORF">BWLFYP14_01579</name>
        <name evidence="13" type="ORF">ERS852478_02334</name>
        <name evidence="14" type="ORF">ERS852523_01607</name>
        <name evidence="15" type="ORF">GT728_12345</name>
    </gene>
    <organism evidence="14 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">2789STDY5834863</strain>
            <strain evidence="14 18">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="15 20" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 20">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="16 19" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L-tetrahydrodipicolinate, to generate the meso compound, D,L-2,6-diaminopimelate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + meso-2,6-diaminoheptanedioate + NADP(+) = (S)-2-amino-6-oxoheptanedioate + H(+) + NADPH + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13561"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58556"/>
            <dbReference type="EC" id="1.4.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the diaminopimelate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.16" evidence="5 10"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO27264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP43588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000029">
        <property type="protein sequence ID" value="MZL33969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705602.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000136_gene980"/>
    <dbReference type="EnsemblBacteria" id="CUO27264">
        <property type="protein sequence ID" value="CUO27264"/>
        <property type="gene ID" value="ERS852478_02334"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP43588">
        <property type="protein sequence ID" value="CUP43588"/>
        <property type="gene ID" value="ERS852523_01607"/>
    </dbReference>
    <dbReference type="GeneID" id="66494451"/>
    <dbReference type="eggNOG" id="COG1712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047850">
        <property type="term" value="F:diaminopimelate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010190">
        <property type="entry name" value="Diaminopimelate_DH_Ddh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032094">
        <property type="entry name" value="Meso-DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16654">
        <property type="entry name" value="DAPDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025648">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAPDH_C" evidence="12">
        <location>
            <begin position="122"/>
            <end position="277"/>
        </location>
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        <location>
            <begin position="10"/>
            <end position="13"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
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        <location>
            <begin position="69"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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        <location>
            <begin position="92"/>
            <end position="94"/>
        </location>
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            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
        <ligand>
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        </ligand>
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        <ligand>
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        <ligand>
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        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001376"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004896"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007442"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR025648"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO27264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUP43588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL33969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VUX64725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="328" mass="36155" checksum="41DFED1740637BB4" modified="2016-09-07" version="1">MSIRIGILGYGNLGRGVECAIKHNPDLELVAVFTRRAPETVKILTETAAVYSVNDAEKMKDKIDVLIICGGSATDLPKQTPEYAKMFNVIDSFDTHARIPEHFDSVDAAAKESGHIGIISVGWDPGMFSLNRLYANAILTNGKDYTFWGKGVSQGHSDAVRRIKGVKDAKQYTIPVEAALEAVRNGENPDLTTRQKHTRECFVVAEEGADLAQIENDIKTMPNYFSDYDTTVHFISEEELKRDHSGIPHGGFVIRSGKTGWNDENNHVIEYSLKLDSNPEFTSSVLVAYARAAYRMNKEGQSGAKTVFDVAPAYLCAADGAELRKHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174P3H5</accession>
    <name>A0A174P3H5_9FIRM</name>
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        <submittedName>
            <fullName evidence="9">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Spermidine/putrescine transport system permease protein PotB</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="8" type="ORF">ERS852523_01926</name>
        <name evidence="10" type="ORF">GT712_14520</name>
        <name evidence="9" type="ORF">GT728_04485</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
            <strain evidence="8 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
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            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BIOML-A1</strain>
            <strain evidence="10 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="5">Multi-pass membrane protein</topology>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZS90251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CUO56305">
        <property type="protein sequence ID" value="CUO56305"/>
        <property type="gene ID" value="ERS852478_03190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP53370">
        <property type="protein sequence ID" value="CUP53370"/>
        <property type="gene ID" value="ERS852523_01926"/>
    </dbReference>
    <dbReference type="GeneID" id="66495743"/>
    <dbReference type="eggNOG" id="COG1176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="MetI-like"/>
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        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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        </location>
    </feature>
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        <location>
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            <end position="264"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO56305.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUP53370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS90251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="271" mass="30565" checksum="DE454197F4B5B240" modified="2016-09-07" version="1">MKQYRNLIKPYLVWAFVVIVIPLILIALYAFTEDGNEVLTFSFTLENFRKFLEATYMSVIFKSFKLGILTTVICLGLGYPLAYIISKCPEKSQSLLILLVTIPEWINMLLRTYAWMNLLSDNGIINHLLGLLGISPVTMMYTDFSVVVGLVCNFMPFMIIPIHTSLSKMDKSFIEAAYDLGANKFQTFTKVIWKLSIPGVLNGIMMVFLLSISTFVIPKLLGGGQYMLIGNLIESQFISVGDWNFGSAISLILAVLILIFMSLMKKMDKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174RH90</accession>
    <name>A0A174RH90_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5,10-methylene tetrahydromethanopterin reductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Methylene-tetrahydrofolate reductase C terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01741</name>
        <name evidence="2" type="ORF">ERS852478_00780</name>
        <name evidence="3" type="ORF">ERS852523_02961</name>
        <name evidence="4" type="ORF">GT712_02860</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000036">
        <property type="protein sequence ID" value="CUP83157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706433.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000011_gene3446"/>
    <dbReference type="EnsemblBacteria" id="CUN67892">
        <property type="protein sequence ID" value="CUN67892"/>
        <property type="gene ID" value="ERS852478_00780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP83157">
        <property type="protein sequence ID" value="CUP83157"/>
        <property type="gene ID" value="ERS852523_02961"/>
    </dbReference>
    <dbReference type="GeneID" id="66493554"/>
    <dbReference type="eggNOG" id="COG4656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
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    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
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    </dbReference>
    <dbReference type="InterPro" id="IPR022026">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12225">
        <property type="entry name" value="DUF5981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5981" evidence="1">
        <location>
            <begin position="109"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN67892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP83157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="206" mass="22760" checksum="013ED2F536404D2E" modified="2016-09-07" version="1">MLITQLKAKEAITSLTAGKKVFIINCHGCKEVRFPEKEAARLQKELAAEGNVTGIMTTDYICNPENMELRLKKHMSKIQEADLVLVFSCGVGVQTVSEYLEDKMVCAACDTYPVPGFQGVTPLEYKCDQCGECYLNLTGGICPITACSKSLVNGQCGGSKNGKCEVDSEMECGWERIYRRLKEIGRLDALKCPTQIHNFATDDELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174TGU7</accession>
    <name>A0A174TGU7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03091</name>
        <name evidence="3" type="ORF">ERS852523_03866</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO52993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000050_gene3087"/>
    <dbReference type="EnsemblBacteria" id="CUO52993">
        <property type="protein sequence ID" value="CUO52993"/>
        <property type="gene ID" value="ERS852478_03091"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ07721">
        <property type="protein sequence ID" value="CUQ07721"/>
        <property type="gene ID" value="ERS852523_03866"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503150Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024760">
        <property type="entry name" value="HTH_dom_conjug_TS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12645">
        <property type="entry name" value="HTH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_16" evidence="1">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO52993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ07721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="89" mass="10554" checksum="5BF677AC86348568" modified="2016-09-07" version="1">MADQTIPDYETIRAAVAGETWAVEKVLMCYKDEIDRQATVKKRQPDGTFKLEIDEDMRQYITMKLIEALPQFPLEEMEREEKRNRDKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WPY7</accession>
    <name>A0A173WPY7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Collagen triple helix repeat (20 copies)</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Collagen-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00031</name>
        <name evidence="3" type="ORF">GT712_07750</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025576995.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41602">
        <property type="protein sequence ID" value="CUN41602"/>
        <property type="gene ID" value="ERS852478_00031"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0176">Collagen</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN41602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS88965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="166" mass="15342" checksum="0113A42922E1AA26" modified="2016-09-07" version="1">MLFSRHTSDDPELSGTSCCNNNNRCSCDCQGPQGPRGCPGPTGPRGCPGPVGPMGPQGPQGEPGLQGYPGPVGPVGATGATGPVGATGATGPAGPSGAIGPTGPAGPIGPTGAAGPAGPTGATGATGPAGTVAPAAAVADATGQTDIVTQFNQLLANLRAAGLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WW63</accession>
    <name>A0A173WW63_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">RNA-binding protein HI_1333</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Ribosome assembly RNA-binding protein YhbY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yhbY</name>
        <name evidence="8" type="ORF">BWLFYP14_02599</name>
        <name evidence="4" type="ORF">ERS852478_00101</name>
        <name evidence="5" type="ORF">ERS852523_01889</name>
        <name evidence="7" type="ORF">GT712_00960</name>
        <name evidence="6" type="ORF">GT728_02940</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">2789STDY5834863</strain>
            <strain evidence="5 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 13">BIOML-A1</strain>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP52120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000005">
        <property type="protein sequence ID" value="MZL32175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703127.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000020_gene125"/>
    <dbReference type="EnsemblBacteria" id="CUN43743">
        <property type="protein sequence ID" value="CUN43743"/>
        <property type="gene ID" value="ERS852478_00101"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP52120">
        <property type="protein sequence ID" value="CUP52120"/>
        <property type="gene ID" value="ERS852523_01889"/>
    </dbReference>
    <dbReference type="GeneID" id="66495924"/>
    <dbReference type="eggNOG" id="COG1534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001890">
        <property type="entry name" value="RNA-binding_CRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017924">
        <property type="entry name" value="RNA-binding_YhbY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035920">
        <property type="entry name" value="YhbY-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01985">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01103">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75471">
        <property type="entry name" value="SSF75471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00253">
        <property type="entry name" value="RNA_bind_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51295">
        <property type="entry name" value="CRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN43743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP52120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL32175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS87694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="98" mass="10976" checksum="4E7DA3754576DC22" modified="2016-09-07" version="1">MTSKQRAYLKGLAMTMDPILQLGKGGLTPENTAAVDEALAARELIKISVLQNCLEDPRQMAEVLAERTRSQIVQVIGKKIVLYREGKNEKKKIELPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WZ78</accession>
    <name>A0A173WZ78_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="6">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="6">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="6">IPP transferase</shortName>
            <shortName evidence="6">IPPT</shortName>
            <shortName evidence="6">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">miaA</name>
        <name evidence="10" type="ORF">ERS852478_00141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6 8">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6 9">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379971.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44791">
        <property type="protein sequence ID" value="CUN44791"/>
        <property type="gene ID" value="ERS852478_00141"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="6">
        <location>
            <begin position="35"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="6">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="6">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN44791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="314" mass="36425" checksum="DA0C7CF88950CC07" modified="2016-09-07" version="1">MKKPLIVLTGPTAAGKTHLSIALAKAVNGEIISADSMQVYKYMDIGSAKIRPEEMQGVKHYLVDELLPQEEFHIVKFQQMAKAAMKEIYAKGKIPVLVGGTGFYIQAITKDIDFTQAEQEDGYRQELEQLAAEKGNEYLHQMLLDVDPVSAGEIHANNVKRVIRALEFYHQNQSPISAHNQEQKEHETPYNLAYFVLNVPRELLYKRIDDRIDEMLKEGLLEEVQKLKDMGYHRGMVSMQGLGYKEILAYLDGEYPLEEAVRILKRDTRHFAKRQLTWFRREKDTIWMNKDEFDYNEDRILDEMLKVCRDRGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X0K0</accession>
    <name>A0A173X0K0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper-exporting P-type ATPase</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Copper-exporting P-type ATPase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Cu(+)-exporting ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">copA_2</name>
        <name evidence="17" type="ORF">ERS852478_00155</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + Cu(+)(in) + H2O = ADP + Cu(+)(out) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052770.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45134">
        <property type="protein sequence ID" value="CUN45134"/>
        <property type="gene ID" value="ERS852478_00155"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00003">
        <property type="entry name" value="TIGR00003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0187">Copper transport</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="815"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUN45134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="884" mass="94347" checksum="55BDCEECB9E55E88" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X178</accession>
    <name>A0A173X178_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02619</name>
        <name evidence="1" type="ORF">ERS852478_00121</name>
        <name evidence="3" type="ORF">GT712_00855</name>
        <name evidence="2" type="ORF">GT728_15990</name>
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    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">BIOML-A1</strain>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000047">
        <property type="protein sequence ID" value="MZL34654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379980.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44315">
        <property type="protein sequence ID" value="CUN44315"/>
        <property type="gene ID" value="ERS852478_00121"/>
    </dbReference>
    <dbReference type="GeneID" id="66495903"/>
    <dbReference type="eggNOG" id="ENOG5033RFH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN44315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL34654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS87674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="165" mass="19255" checksum="B40605E4EB85B8BB" modified="2016-09-07" version="1">MNEKFRTIGLDTEDKITEFIDYIDDLEDTEEIKSDVYGFFEEESSYNENHIPAYVVMTKYKGKYIVWVEDQCCDFAISYPPYNLCDIFSTYDEANEYYKSLAHSGIKPLSEQVEECKSQLIDEVDLRVSTMVPNVLNIKVWYKNCLIIEHLTQFDVQYINNGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X1K3</accession>
    <name>A0A173X1K3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Aldose 1-epimerase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mro</name>
        <name evidence="11" type="ORF">ERS852478_00175</name>
    </gene>
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        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4 7"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381415.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45652">
        <property type="protein sequence ID" value="CUN45652"/>
        <property type="gene ID" value="ERS852478_00175"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="179"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN45652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="353" mass="39071" checksum="9B9B150012AB34E6" modified="2016-09-07" version="1">MSVSERKFGILQTGETVKIFHLENKSGAYAEVTDFGAILVKVCVPDKDGTLTDVVLGYDDLASYEVNGCFFGSTIGRNGNRIGGAKFSVNGKEVVLAQNENDNNLHSGPDGFEKKLWKVAEISDDKNSVIFNRISPDGENGFPGEFDVSVKYEFTEDNELRIHYQGICDEPTVANMTNHSYFNLNGEGSGTAMDQYLTIHAKYYTPVADSHSIPTGVYGEVAGTPMDFRTAKKIGQDIEAEFDQLKFTGGYDHNYVTDNYAKGNRRLIATAYSDKTGIAMDVTSDCPCVQFYAANFVENEHGKNGHTYNKRDAFCLETQVEPNAVNVEDFHSPILNAGEQYDSVTAYHFYIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XEY8</accession>
    <name>A0A173XEY8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00262</name>
        <name evidence="3" type="ORF">GT712_15845</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000040">
        <property type="protein sequence ID" value="MZS90498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49195">
        <property type="protein sequence ID" value="CUN49195"/>
        <property type="gene ID" value="ERS852478_00262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN49195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="127" mass="14785" checksum="E70727C346774F57" modified="2016-09-07" version="1">MIEQSIDDGEAYRIVLDGKKVGGVVIKVEGEKGDLDLLFVAPSVHSKGIGYAAWCEVEKLHPEVKVWETVTPYFEQRNIHFYVNRCGFRIVEFFDKYHQDPNDPEMNAEKQDEQFPDGMFRFEKVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XFZ6</accession>
    <name>A0A173XFZ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577570.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50659">
        <property type="protein sequence ID" value="CUN50659"/>
        <property type="gene ID" value="ERS852478_00310"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006938">
        <property type="entry name" value="DUF624"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04854">
        <property type="entry name" value="DUF624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN50659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="214" mass="24501" checksum="B4F99A59B16A2759" modified="2016-09-07" version="1">MKRFFGTDSPSFRFMTILLELAEINLLFLLCSIPIVTIGAAYSAMLHSLYGMHKYGEGCFSVKMFFRVFRRSLKPLIPAWCVIVICYILLGCNINYIINNTQGMIRFIGCGVYIVLLLFVSGIMQYLSIFVALSEKWNRDFLKNSFLLTLAKFPVVILTSLLSMSVFIVALFPVSMMLRLLPLVILFWIVCPAYVCVGIHMRVLKPLFPELFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XI76</accession>
    <name>A0A173XI76_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Predicted membrane protein, putative toxin regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852478_00333</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199572.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51333">
        <property type="protein sequence ID" value="CUN51333"/>
        <property type="gene ID" value="ERS852478_00333"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13303">
        <property type="entry name" value="PTS_EIIC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="PTS_EIIC" evidence="9">
        <location>
            <begin position="22"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN51333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="363" mass="37575" checksum="BA45991A9419FAEC" modified="2016-09-07" version="1">MEKFKAFLRRKDIEISIKRYGIDALGAMAQGLFCSLLIGTIINTLGTQFHISFLTTAVATVNDTQYTVGSLASAMSGPAMAVAIGYALHCPPLVLFSLITVGFASNALGGAGGPLAVLFVAIFASEIGKAVSKETKIDILVTPLVTIGVGVALSAWWAPALGSAAMKVGNIIMWATNLQPFLMGILVSVFVGIALTLPISSAAICAALGLTGLAGGAAVAGCCAQMVGFAVMSFRENKWGGLVSQGIGTSMLQMGNIVKNPRIWIAPILTSAITGPLATCLFKLQMNGTPVSSGMGTCGFVGQIGVYTGWMNDIAAGTKTAVTGWDWAGLLLISFILPAILCPLINMFARKLGWVKDGDMTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XIF9</accession>
    <name>A0A173XIF9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-serine deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">sdhB</name>
        <name evidence="13" type="ORF">BWLFYP14_01952</name>
        <name evidence="11" type="ORF">ERS852478_00336</name>
        <name evidence="12" type="ORF">ERS852523_01528</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">2789STDY5834863</strain>
            <strain evidence="12 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000013">
        <property type="protein sequence ID" value="CUP41184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577539.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000050.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000008_gene2679"/>
    <dbReference type="EnsemblBacteria" id="CUN51424">
        <property type="protein sequence ID" value="CUN51424"/>
        <property type="gene ID" value="ERS852478_00336"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP41184">
        <property type="protein sequence ID" value="CUP41184"/>
        <property type="gene ID" value="ERS852523_01528"/>
    </dbReference>
    <dbReference type="GeneID" id="66495966"/>
    <dbReference type="eggNOG" id="COG1760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004643">
        <property type="entry name" value="Fe-S_L-Ser_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036692">
        <property type="entry name" value="SDH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00719">
        <property type="entry name" value="sda_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="150"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR036692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN51424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP41184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX65330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="222" mass="24597" checksum="41CD68D52C2C8244" modified="2016-09-07" version="1">MSFISVFDVMGPNMIGPSSSHTAGAARISYLAQKMIEGPLKRADFILYGSFAKTYHGHGTDRALLGGIMGFSTDDMRIRNSFDIAHEKGLKFSFTPNEQETDIHPNTVDICMENEKGQKMTVRGESLGGGKVRIVDINHVQVDFTGEYSAVIVIHQDTPGVVAYITKCLSDRNINIAFMRLFRESKGEIAYTIVESDGKLPENIVPAIRENPNIHEVMIVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XJS0</accession>
    <name>A0A173XJS0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0597 protein BWLFYP14_01969</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_01969</name>
        <name evidence="3" type="ORF">ERS852478_00349</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0597 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577516.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51883">
        <property type="protein sequence ID" value="CUN51883"/>
        <property type="gene ID" value="ERS852478_00349"/>
    </dbReference>
    <dbReference type="GeneID" id="66495980"/>
    <dbReference type="eggNOG" id="COG3681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01845">
        <property type="entry name" value="UPF0597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021144">
        <property type="entry name" value="UPF0597"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30501">
        <property type="entry name" value="PTHR30501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006054">
        <property type="entry name" value="UCP006054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_alpha" evidence="2">
        <location>
            <begin position="139"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN51883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="425" mass="45804" checksum="C2B4242458DCCD6D" modified="2016-09-07" version="1">MLDERIYESYIGILKEEMVPAMGCTEPIALAYGAARAREVLGKEPEHITAKCSGNIIKNVRCVIIPNSGGLTGIEAGVVLGAVAGNASLNMEVLSNVNEFERKRCRELLDKKICKVELLDSPVVLHFIIEMQAGDDTVSLEIKYDHINVTKIVKNQEVLLDSDHKSGETPAAADRTLLNLEDIKTFADTVEIDDVKEIIENQIRSNMAIAHEGMTGKYGLGIGRIIRETYSNDMLTKMRSLTAAASEARMGGCDMPVVINSGSGNQGIACSVPLIVYAREMELPDYVLYRALVFSNLLTVYQKQYIGKLSAFCGAVSASCAAGAGITYMGGGELSVIKKTIENTLANIPGIICDGAKISCAAKIAASLDAAFLAHHLAMNGQSYAPYTGILKEEAGETISCVGQIGKEGMKETDKEILRIMLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XNY3</accession>
    <name>A0A173XNY3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, y4mF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00406</name>
        <name evidence="3" type="ORF">ERS852523_04333</name>
        <name evidence="4" type="ORF">GT728_06285</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000103">
        <property type="protein sequence ID" value="CUQ19412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000011">
        <property type="protein sequence ID" value="MZL32823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055154121.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53602">
        <property type="protein sequence ID" value="CUN53602"/>
        <property type="gene ID" value="ERS852478_00406"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ19412">
        <property type="protein sequence ID" value="CUQ19412"/>
        <property type="gene ID" value="ERS852523_04333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ19412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="67" mass="7811" checksum="AB3FE9F77B172D15" modified="2016-09-07" version="1">MEAKFVCNLKKYRVAQELTQEQLADIVGVRRETIMRLEKAQYNPSLKLAIDISRVVKAPIEDIFIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XSJ1</accession>
    <name>A0A173XSJ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Autolytic lysozyme</fullName>
            <ecNumber evidence="4">3.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lyc_1</name>
        <name evidence="4" type="ORF">ERS852478_00450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199630.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54922">
        <property type="protein sequence ID" value="CUN54922"/>
        <property type="gene ID" value="ERS852478_00450"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NlpC/P60" evidence="2">
        <location>
            <begin position="27"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="3">
        <location>
            <begin position="247"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN54922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="295" mass="31648" checksum="9E2E675AF9BAC3D6" modified="2016-09-07" version="1">MTKTEKAVTWAIEIANDPAHGYDQDNRWGPDYDCSSLVISAWQQAGVPVKTKGATYTGNMKSVFLSCGFKDVTSKVNLSTGSGMKRGDVLLNIASHTVMHIGNGQVVSASKNENNGYHGGKPGDQSGKEIKLQNYYNFPWDCVLRYTEDSSTTDPEPQPTTGNAKIRKGQSYANKFANAGISITGKRDAATKKAGIKVLQTALNRDYGAGLDVDGIWGTNTSDALGKHYVKSGETQYMVTAAEILLLLRAYDPNGVEIPGTFGSGLLSAVKAFQKAQGLTVSGTCDRNTFLKLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XU30</accession>
    <name>A0A173XU30_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199620.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54426">
        <property type="protein sequence ID" value="CUN54426"/>
        <property type="gene ID" value="ERS852478_00434"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033PYD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015672" evidence="2">
        <location>
            <begin position="28"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN54426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="381" mass="40195" checksum="425165D2CD4E341D" modified="2016-09-07" version="1">MKNKRVLMLLAVTTVLSVSMTACFGGGSDEDSSVVQVTPTPEPTKAAKATPTPAPANAQNTTYTSKNKAVSIKLPDATWANKSDSDDMLSFESPKQGKLLILHGSGEEDMSVAIIPSSQDTASALVKADNLVEGTDFEIQDYKSEEVSGVNVYSYTVHYLTDKSDYKYVVNKYFTDNTTEFYSVAGSVKDEKALAEIKTSVDSFTISGDSVLKAAATGKTSGTTAGTTADGTSGTTGTAAAGTDTTASGSSSDGSSSAGTDGSYNGTSSDGSSDYSSSDYTSDGSSDGSYDYDDGSSNGYYADGTPVGTDDPDYDTDQTRTIYRNSDGYPLVIYPNGDGTWCDDDGNTYDFANGEDVYDENGVDYYYHGEPAYVRYMPKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XUT3</accession>
    <name>A0A173XUT3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">clpB</name>
        <name evidence="12" type="ORF">ERS852478_00424</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199614.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54138">
        <property type="protein sequence ID" value="CUN54138"/>
        <property type="gene ID" value="ERS852478_00424"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="11">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="404"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN54138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="863" mass="97489" checksum="3BE660FC5C33CAED" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XXE0</accession>
    <name>A0A173XXE0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199643.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56113">
        <property type="protein sequence ID" value="CUN56113"/>
        <property type="gene ID" value="ERS852478_00460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN56113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="64" mass="7692" checksum="C8DEA0E1F6E6639A" modified="2016-09-07" version="1">MTKDFIVRPKYTDKKEDKSITMTIRLERELQEEYDKLSAKSGRSRNELMCMALRYALENLKFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XZJ5</accession>
    <name>A0A173XZJ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable ABC transporter permease protein HI_1471</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_00481</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199664.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56823">
        <property type="protein sequence ID" value="CUN56823"/>
        <property type="gene ID" value="ERS852478_00481"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN56823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="347" mass="37627" checksum="DDC744D74B1D28D3" modified="2016-09-07" version="1">MNLTANEKNAAAARQRRYVLLLAVMLVLLFIIIVLSFWVGYYPLTPVQVLNAFLSKFGFKGDILPQAVTIFWNIRLPRILSALFIGASLSVAGATYQGMFRNPLVSPDILGVSSGASLGAAFAILNGASNWMIQLSAFAGGVATVAASYLISRKSAHSQTLSLVLTGTMIMSLCNAGVTMIKYVADPNDVLQQITFWLMGSLTKATTKSFCWSVLPMIIGLSLIFIFRWQINLLTLDEEEAKSLGINVRKYRLIFIVASTLLSAAAVCLGGLIGWVGLMIPHLARALVGVDYRRLIPASAILGGGYLILVDDISRSLLSMELPLGVVTSIMGAPFFIYLIIKRKERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y1N7</accession>
    <name>A0A173Y1N7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arabinose metabolism transcriptional repressor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">araR</name>
        <name evidence="3" type="synonym">araR_1</name>
        <name evidence="5" type="synonym">araR_2</name>
        <name evidence="5" type="ORF">BWLFYP14_02119</name>
        <name evidence="2" type="ORF">ERS852478_00519</name>
        <name evidence="3" type="ORF">ERS852523_01352</name>
        <name evidence="4" type="ORF">GT728_11375</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000011">
        <property type="protein sequence ID" value="CUP35577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000026">
        <property type="protein sequence ID" value="MZL33780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000038">
        <property type="protein sequence ID" value="VUX65640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708150.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000106_gene670"/>
    <dbReference type="EnsemblBacteria" id="CUN58102">
        <property type="protein sequence ID" value="CUN58102"/>
        <property type="gene ID" value="ERS852478_00519"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP35577">
        <property type="protein sequence ID" value="CUP35577"/>
        <property type="gene ID" value="ERS852523_01352"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01541">
        <property type="entry name" value="PBP1_AraR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033532">
        <property type="entry name" value="AraR_ligand_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN58102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP35577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="363" mass="41322" checksum="5A3B3F7800D94FA1" modified="2016-09-07" version="1">MTDNGKPKYFSLMEQLRSDIMSGAIRPGEKLPSENELSQKYSLSRHTVRKALGILEQDGYVEAFHGRGTYCSENMRHIKNSKNIAVVTTYISDYIFPRLIQGMDNVLSESGYSIILKNTANSRQKEARCLEELLKKDIDGLIIEPSKSEMICKHRNLYQNLDKFEIPYVFIQGIYSEMRDKPHILMDDAQGGYLVTKYLLELGHKKIKGFFKADDMQGLERHKGYVKALQESGIAYDPDDVVWFHTEDRKVKPALMAKEMVQSGQLPDGIVCYNDQIAVQVMEELEKMGVRIPDDISITGYDNSLYAQRGSGITTIAHPQEKLGEMAAELILEKINGVPEEESKVERLIYPELIIRGSCRKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y452</accession>
    <name>A0A173Y452_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00549</name>
        <name evidence="3" type="ORF">ERS852523_03068</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000038">
        <property type="protein sequence ID" value="CUP86052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055152703.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000024_gene280"/>
    <dbReference type="EnsemblBacteria" id="CUN58952">
        <property type="protein sequence ID" value="CUN58952"/>
        <property type="gene ID" value="ERS852478_00549"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP86052">
        <property type="protein sequence ID" value="CUP86052"/>
        <property type="gene ID" value="ERS852523_03068"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZMBN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN58952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP86052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="278" mass="31654" checksum="D765EC8A804F1575" modified="2016-09-07" version="1">MKVLSQARRICGYQLRILRGNYKLYLIPVCLFVYMLNELIPIRDFLFSVNEKASPFLLPFIFNDVMLTASIFVAAMLFFIDAPFYDKYQLFVIMRGGTSEWVLGHIMYIFSVSILYMLCLTGISILIIFPNVCLSGEWGRIWTTLALTDAGEQFGLSFGVSGYLIFEYRPLEAMFLVGGLGFFICSFYGLCLWCLNLCVGKIISFVTVSASIILVTRIKYLPEWIMYLTPSAWMDLNNLSKYARYEIDVVRAFIILVLGCLCLSGIAYYVTVHSDISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YBG3</accession>
    <name>A0A173YBG3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rpsT</name>
        <name evidence="9" type="ORF">ERS852478_00598</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199717.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60547">
        <property type="protein sequence ID" value="CUN60547"/>
        <property type="gene ID" value="ERS852478_00598"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016069" description="30S ribosomal protein S20" evidence="8">
        <location>
            <begin position="38"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN60547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="87" mass="9281" checksum="C59A477E279B3B74" modified="2016-09-07" version="1">MANIKSAKKRILVNRTKAARNKAIKSAVKTSMKKVEAAVANKDKAAAEVALKDAVSTISKATSKGVYHKNNCARKVARLSKAVNSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YQJ7</accession>
    <name>A0A173YQJ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Domain of uncharacterized function (DUF3786)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199777.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65850">
        <property type="protein sequence ID" value="CUN65850"/>
        <property type="gene ID" value="ERS852478_00725"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033JQC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024264">
        <property type="entry name" value="DUF3786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12654">
        <property type="entry name" value="DUF3786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3786" evidence="1">
        <location>
            <begin position="29"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN65850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="208" mass="23768" checksum="91AC29B885F76726" modified="2016-09-07" version="1">MEYKNQTENRAFQEMLQAAVKRLQNRSGEDIAAKSGAVFHSSRNVLEVRSFYETIEIQLPEFRINSDMDEWHYLTLLHYLDMADGTEGSQKLITFGNLKDGLIRGTKFDRTAEQKLEKLLQDKDPEKIQKACKNLGAEFTETKADLCAVFPVLPRYPVTLKIWFADEEFPASGKIFLQDHADHYLSVEDAVTVGEILLQKLSEAFSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZJA7</accession>
    <name>A0A173ZJA7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_7</name>
        <name evidence="7" type="ORF">ERS852478_00986</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75245">
        <property type="protein sequence ID" value="CUN75245"/>
        <property type="gene ID" value="ERS852478_00986"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="86"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN75245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="290" mass="32431" checksum="8A03701E6B545B9D" modified="2016-09-07" version="1">MAKTAAPKTMESNHKIATVLSTGLFAILGVLIAFPLLAGFFASFQEGREVVMKGMSLNLDFSKMHLDNYKYLFSGNEDSRKYFMWYKNSLILTLITVVLTLLVCYFIAYGLTMYKFKLQGFLFFLVIATMCVPFEILMLPLYNEVTSLGIINTRAGVILPGLCGASTIFFFKQYMQSLPKELLDAGRIDGCTEYGISVKIMMPITKPAFASMAILCAMGSWNNMLWPMLVFRDTSKFTLQIGLNTLLTPYGNNYNLLIAGSMFGILPILIIYLIFQRYLIDGMTSGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZLE9</accession>
    <name>A0A173ZLE9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactaldehyde reductase</fullName>
            <ecNumber evidence="3">1.1.1.77</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fucO</name>
        <name evidence="3" type="ORF">ERS852478_01023</name>
        <name evidence="4" type="ORF">GT712_17275</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.77" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000049">
        <property type="protein sequence ID" value="MZS90760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199902.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76450">
        <property type="protein sequence ID" value="CUN76450"/>
        <property type="gene ID" value="ERS852478_01023"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008912">
        <property type="term" value="F:lactaldehyde reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013460">
        <property type="entry name" value="Lactal_redase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02638">
        <property type="entry name" value="lactal_redase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="11"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN76450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="381" mass="41201" checksum="7A4D5177A46BAED7" modified="2016-09-07" version="1">MANRINLNQTSYHGAGAIEEIANEAKAHGFKKAFVCSDPDLVKFHVTSKVTDILEKNGLAYELYSDIKPNPTIENVQHGVQAFKDSEADYLIAIGGGSSMDTSKAIGIIIANPEFEDVRSLEGTAPTRKPCVPIIAVPTTAGTAAEVTINYVITDVERKRKFVCVDPHDMPIIAVIDPEMMSSMPKGLTASTGMDALTHAIEGYTTKAAWEMTDMFHLKAIELISKSLRGAVENTKEGREGMALGQYIAGMGFSNVGLGIAHSMAHTLGAVYDTPHGVACAMMLPIVMEYNQECTGEKYREIARAMGVKGVDEMSQDEYRKAAIEAVKKLSVDVGIPTKLEAIKEEDLQFLAESAHADACAPGNPKDASVEDLKDLFRKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZTZ4</accession>
    <name>A0A173ZTZ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stage 0 sporulation protein A homolog</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">luxQ_2</name>
        <name evidence="15" type="ORF">ERS852478_01059</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707383.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78668">
        <property type="protein sequence ID" value="CUN78668"/>
        <property type="gene ID" value="ERS852478_01059"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
            <end position="927"/>
        </location>
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        <location>
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            <end position="530"/>
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    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="552"/>
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        <location>
            <begin position="800"/>
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        <location>
            <position position="852"/>
        </location>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
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        <source>
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        </source>
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            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUN78668.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="927" mass="105342" checksum="EC3C8C78F72B67ED" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZVB4</accession>
    <name>A0A173ZVB4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug-efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mdtK_2</name>
        <name evidence="2" type="ORF">ERS852478_01084</name>
    </gene>
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        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="matE"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
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        </location>
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            <end position="199"/>
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        </location>
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        </location>
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            <begin position="423"/>
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        </location>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="453" mass="49040" checksum="128A920045C3BAD2" modified="2016-09-07" version="1">MCENEKKKYHSIEMTTGSLWKNILLFSLPLMGSQVLEVLFNLSDVAVVGRFADYMALGAVGSTTLLVTLFTGILIGMGAGVNVRVAHELGAGNKKGTEETIHTSLLLCAITGLLVCTICLLFSGRMLSMMNTKPELIDQAILYMKIYSLGMPAMAVYNFGNGVLSAIGDTKRPLIYLSIAGVVNVLLNLFFVIVCHMAAAGVATASAISLYISASLVMIHLLRRTDDCKVSLRKIRLHPKACKAVLMLGIPTGLQNGIFAIANLFVQTGVNSFDAVMVSGNAAAANADSLIYNVMFSFYTACASFIGQNWGAGNKKRMLKSYRVSLTYAFIFGAILGGLLLVFGPQFLSLFATEPTVIDAGMQRIRIMAFSYAFSCFMDGSIAASRGIGKSIPPTIIVILGSCVFRIVWIYTVFAHFQTISSLYLLYIFSWGITGLAETLFFVVSFKKIWAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A008</accession>
    <name>A0A174A008_9FIRM</name>
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        <submittedName>
            <fullName evidence="7">Anaerobic ribonucleoside-triphosphate reductase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_01116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80738">
        <property type="protein sequence ID" value="CUN80738"/>
        <property type="gene ID" value="ERS852478_01116"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="PTHR43075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="77"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN80738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="323" mass="36793" checksum="7156830076C73359" modified="2016-09-07" version="1">MKVNKIQTEENKDKTLRHDTESCILADCSLCPRNCHVDRTAGKTGYCGMDQKVKIARAALHMWEEPCISGTRGSGAVFFTGCNLRCCFCQNREIAIGDSGLEITEERLAEIFLELQEKDAANINLVTGTHYIPQIIAALDCAKKHGLNIPVVYNCGGYENTETLKLLDGYVDIYLPDYKYAESELAVKFSHANDYPERAMEAVNEMVRQTGMPQFDAEGYMKRGTIVRHLILPGHTRNSKKVLKLLHKTFGKQIYISIMNQYTPVFEQKEYTELNRCVTRREYEKVLDYAFELGIENGFFQDGETARESFIPAFDYEGVRKMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A2D3</accession>
    <name>A0A174A2D3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">recX</name>
        <name evidence="6" type="ORF">ERS852478_01175</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82751">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00003529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN82751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="195" mass="23133" checksum="736922E9BD529E2E" modified="2016-09-07" version="1">MGNSSGDLREFLRNAEALKRQTVQKQQKNLTEEPEEYRDARRKAMRLLEHMDRTEKGLREKLRQAGFTSQAVDHALTYVEAYGYIDDERYARTYIAYRMDTKSRQKIIRELMGKGIDRKTAINAWEEEAALNMPDEKEILYRTIEKKYPPDTELDEKKMRRLYGYLVRRGFGYSDIADTLENMNIRLVHTYSDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A8D2</accession>
    <name>A0A174A8D2_9FIRM</name>
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        <submittedName>
            <fullName evidence="4">Cellobiose phosphorylase</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">ERS852478_01210</name>
    </gene>
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        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84119">
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        <property type="gene ID" value="ERS852478_01210"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR037018">
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    </dbReference>
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        <property type="entry name" value="Glyco_hydrolase_94"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_transf_36" evidence="2">
        <location>
            <begin position="116"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_36" evidence="3">
        <location>
            <begin position="624"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN84119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="900" mass="101753" checksum="171554E2AB1F9E91" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ABF5</accession>
    <name>A0A174ABF5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852478_01228</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
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            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN85737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006857260.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN85737">
        <property type="protein sequence ID" value="CUN85737"/>
        <property type="gene ID" value="ERS852478_01228"/>
    </dbReference>
    <dbReference type="GeneID" id="61431742"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="655"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="289"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="684"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN85737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="784" mass="86645" checksum="F0DA487B506D1B4F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AND0</accession>
    <name>A0A174AND0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF5067 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_01344</name>
        <name evidence="6" type="ORF">GT712_17820</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000054">
        <property type="protein sequence ID" value="MZS90859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025581289.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89947">
        <property type="protein sequence ID" value="CUN89947"/>
        <property type="gene ID" value="ERS852478_01344"/>
    </dbReference>
    <dbReference type="GeneID" id="66494898"/>
    <dbReference type="eggNOG" id="ENOG5032XM9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031989">
        <property type="entry name" value="DUF5067"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16729">
        <property type="entry name" value="DUF5067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5067" evidence="4">
        <location>
            <begin position="218"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN89947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS90859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="353" mass="39232" checksum="488136EACAC816AB" modified="2016-09-07" version="1">MTKGNKKGHAGLIIFILILVLVIGGGTGFYFYQRQQPRKAVENFLDSMKKMDFNAMESMIQSSDLTALDNADIRDAAYTDFFSEINKKMTYKITRNRFDIQNGTASVTAHITYIDGTNIYKATITEFLRQIVSNAYAGNQLTEEETQAKLASILNEQAKKVEKDVFSETDITYPVIKTDSGWKIVSLDDETVKIMSANFKSVEEEINNSLNNMDNEDSSGSSSNAPEASADDTLNLTTEKFTIKYTKHTITKDFAGNPCIMVYYDYTNNSSSASSAMVDVSLKAYQHGESCEAAIPENNDDAIDHFTAEIQPGQTVNVCQAFTLTDESDVTVQAQEAFSFDEDANARQILKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AQ28</accession>
    <name>A0A174AQ28_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein HflK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hflK</name>
        <name evidence="8" type="ORF">ERS852478_01375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">HflC and HflK could encode or regulate a protease.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">HflC and HflK may interact to form a multimeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the band 7/mec-2 family. HflK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90891">
        <property type="protein sequence ID" value="CUN90891"/>
        <property type="gene ID" value="ERS852478_01375"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03404">
        <property type="entry name" value="SPFH_HflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010201">
        <property type="entry name" value="HflK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF2">
        <property type="entry name" value="PTHR43327:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01933">
        <property type="entry name" value="hflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="7">
        <location>
            <begin position="37"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN90891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="340" mass="38065" checksum="BE9020787F11AFB9" modified="2016-09-07" version="1">MNERVNPFKKLQKPGKHVKRIVIGAAGLVIIAGLAGDATYQIQEQEQAVLTTFGVPKAVAETGLHFKIPFIQKVQKVNTTIQGFPIGYSMGDNSVVENEGIMITSDYNFIDVDFFVEYRILEPVKYLYNSEEPEDILKNISQSCIRTVIASYDVDEVLTTGKGEIQSKIKEMILKQMEEQDLGIQLVNITIQDSEPPTQEVMKAFKAVETAKQGKETALNNANKYRNEKLPEAEAEADQIIQDAEAQKQVRINEAEAEVARFNAMYEEYVKNPEITKKRMFYEAMEDVLPGMKIVIDNGDGVQKVLPLDSFTGNSSENPAETLNTDPAQDTQDLNDSENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ASH4</accession>
    <name>A0A174ASH4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4179 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200032.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90398">
        <property type="protein sequence ID" value="CUN90398"/>
        <property type="gene ID" value="ERS852478_01361"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBJ9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025436">
        <property type="entry name" value="DUF4179"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13786">
        <property type="entry name" value="DUF4179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4179" evidence="2">
        <location>
            <begin position="91"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN90398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="584" mass="66121" checksum="80F587E12072889E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B1T0</accession>
    <name>A0A174B1T0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93585">
        <property type="protein sequence ID" value="CUN93585"/>
        <property type="gene ID" value="ERS852478_01422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046053">
        <property type="entry name" value="DUF6011"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19474">
        <property type="entry name" value="DUF6011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN93585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="66" mass="7454" checksum="C266313905CC3C6F" modified="2016-09-07" version="1">MYSKCQKCGRKLTDPESIERGYGPECWGSILPHYSIEQEEPEESIPGQMTIEDFLGGLKNGEKDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B994</accession>
    <name>A0A174B994_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type IV secretory pathway, VirB4 components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200127.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97357">
        <property type="protein sequence ID" value="CUN97357"/>
        <property type="gene ID" value="ERS852478_01531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN97357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="801" mass="90520" checksum="D801F912DD94F65B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BKL8</accession>
    <name>A0A174BKL8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Energy-coupling factor transporter transmembrane protein EcfT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ecfT_1</name>
        <name evidence="6" type="ORF">ERS852478_01617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057326.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01294">
        <property type="protein sequence ID" value="CUO01294"/>
        <property type="gene ID" value="ERS852478_01617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO01294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="245" mass="26655" checksum="E8BFA7EECDB64009" modified="2016-09-07" version="1">MSRELLASQKSNSGIILDPRTKLAVLITIAVFILGGSYEGIMQYYIIVLAAIPLLLLLAAKKWKDSVLYILIFGGSLCLKMFGLSRLTGVLNYIAVAVVGILLRFTPGIVMGYFVVTTTTVSEFVAAMERIHLPKQITIPMSVMFRFFPTVAEEWSAIGDAMRMRGVRFGGGKAGTILEYRMVPMMICSVKIGEELSAAALTRGLGGPVKRTNICKLGFHVQDVILLLICIGAFAAQIYVLVARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BUU4</accession>
    <name>A0A174BUU4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="6">6.3.5.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purL</name>
        <name evidence="6" type="ORF">ERS852478_01696</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.3" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380650.1">
        <property type="nucleotide sequence ID" value="NZ_JAAINB010000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03929">
        <property type="protein sequence ID" value="CUO03929"/>
        <property type="gene ID" value="ERS852478_01696"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0046">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010141">
        <property type="entry name" value="FGAM_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01857">
        <property type="entry name" value="FGAM-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="5">
        <location>
            <begin position="180"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="443"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO03929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1254" mass="138714" checksum="3BC0E1BB47F36EF4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BYJ1</accession>
    <name>A0A174BYJ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized ABC transporter ATP-binding protein YheS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yheS_2</name>
        <name evidence="5" type="ORF">ERS852478_01699</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO04720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009247522.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO04720">
        <property type="protein sequence ID" value="CUO04720"/>
        <property type="gene ID" value="ERS852478_01699"/>
    </dbReference>
    <dbReference type="GeneID" id="61850123"/>
    <dbReference type="GeneID" id="66882333"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="321"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="356"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO04720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="514" mass="59308" checksum="D956DF50901F02EF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C0E5</accession>
    <name>A0A174C0E5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Inner membrane symporter yicJ</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yicJ_1</name>
        <name evidence="9" type="ORF">ERS852478_01748</name>
        <name evidence="10" type="ORF">GT712_12125</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200221.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06337">
        <property type="protein sequence ID" value="CUO06337"/>
        <property type="gene ID" value="ERS852478_01748"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001927">
        <property type="entry name" value="Na/Gal_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018043">
        <property type="entry name" value="Na/Gal_symport_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00792">
        <property type="entry name" value="gph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00872">
        <property type="entry name" value="NA_GALACTOSIDE_SYMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO06337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS89800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="456" mass="49705" checksum="31B214110F6AC12B" modified="2016-09-07" version="1">MEEKKYLKWYNKVGYGSGDIAGNVVFAFLSSFIMIYLTNTVGLNAGVIGSLIAVSKVLDGISDVIFGSMIDKTHTKMGKARPWMLGAYFGCAITLIAAFSVPTTMGRTSQYIWFFITYLLLNAGFYTANNIAYSTLTALITKNGKERVQMGSIRFMFAFGTSFIIQTITVDLVQKLGGGAAGWRTIAIIYAIIGLISNTITVFSVKELPEEELRDGNTEKAEEKYSLIGSIKMLIHNKYYLVILVVDILRQTYSAIINMGIFYMTYVLGKAELLGTFSGAINLALIVGLAFLPSLVAKFKGYYKLNFSGYLVAAAGRGIVIVAGYMGNVPLMLAGTAIGAIGMAPWQGNLNALVAECSEHTFLQYGKRIDGTMFSCTSMGLKIGSGLGTAIVGWLLDFGGFNGKLAVQSQSCINMLHFMYLWLPMLINILVALLLTQLNVEKANEKLRAQKAIKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C0H5</accession>
    <name>A0A174C0H5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852478_01714</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057778.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05278">
        <property type="protein sequence ID" value="CUO05278"/>
        <property type="gene ID" value="ERS852478_01714"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1269">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="PTHR11629"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO05278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="646" mass="73605" checksum="8EF9F805A2119E00" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C3R9</accession>
    <name>A0A174C3R9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxide-responsive repressor perR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">perR</name>
        <name evidence="3" type="ORF">ERS852478_01754</name>
        <name evidence="4" type="ORF">GT712_12100</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200226.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06520">
        <property type="protein sequence ID" value="CUO06520"/>
        <property type="gene ID" value="ERS852478_01754"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO06520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="137" mass="15642" checksum="76985B202AB95B27" modified="2016-09-07" version="1">MATLKYSRQRESIKEFLRTRKDHPTADVVYENMKLIYPNISLGTVYRNLSLLADLGEIKKLSSFAGADHFDGRTERHCHFMCTRCERIIDLESEGIHHIMELAGENFGGKITDYSARFFGLCEDCLKEAEGNSDSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CA39</accession>
    <name>A0A174CA39_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein, YkwD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053669.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10014">
        <property type="protein sequence ID" value="CUO10014"/>
        <property type="gene ID" value="ERS852478_01841"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013378">
        <property type="entry name" value="Listeria/Bacterioides_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042229">
        <property type="entry name" value="Listeria/Bacterioides_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02543">
        <property type="entry name" value="List_Bact_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019037" evidence="2">
        <location>
            <begin position="28"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="265"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO10014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="469" mass="51712" checksum="18D4735AF62B31DB" modified="2016-09-07" version="1">MKRKRFSFLALLVLAVMLLMPASTQAAAKLGTVKLSSIKAVDYNKINIKWKKTSGATNYIVYYKKSGDKKWIKVKTLDNKKTSYTHTSSSKYPIVVGQKYTYTIKSYNKNTKKSGNYNKNGLTTKTIPATVYGLGAGLTGDNTVNVSWNPAGGTTHYVIYRKANDSTPIKIATVSSKYTKYEDKNPVEGATNTYFVFGYSSKFKVYGDGSNTGVSIKVKKKVTPTPEPTSKPENPGDDNNDNNHGDNDDDFDDPVDPIAMASEVLRLTNIERAKEGAQPLKYNKTIQDAAMIRAKEISVKFSHERPNGTSYKTILGCVNGENIAMGYGDAESVVEGWMSSSGHKVTMLDNRYQYLGVGFYESDNGNYYWVQDFSTGNPDASGSIVFNANGGLINGKSSYTISGSAGSQVWLYDAPEQFEVTNIPVPIRDGFTFAGWYDTLTPSSNRKPLKMAIYTSNGMMLYAKWIPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CF05</accession>
    <name>A0A174CF05_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02231</name>
        <name evidence="1" type="ORF">ERS852478_01898</name>
        <name evidence="3" type="ORF">GT712_19515</name>
        <name evidence="2" type="ORF">GT728_10845</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">BIOML-A1</strain>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000023">
        <property type="protein sequence ID" value="MZL33683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000078">
        <property type="protein sequence ID" value="MZS91158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11743">
        <property type="protein sequence ID" value="CUO11743"/>
        <property type="gene ID" value="ERS852478_01898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO11743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL33683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS91158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="47" mass="5228" checksum="301525DA09BB62DF" modified="2016-09-07" version="1">MRVNGADSVTTAVLIGNTPEVNENFYTYDVSESDYKKELIRKVSLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CGT9</accession>
    <name>A0A174CGT9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trxA_3</name>
        <name evidence="4" type="ORF">ERS852478_01864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200381.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10726">
        <property type="protein sequence ID" value="CUO10726"/>
        <property type="gene ID" value="ERS852478_01864"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO10726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="107" mass="11885" checksum="2B50808FF2EBD4E5" modified="2016-09-07" version="1">MAAMNMNQEQFKQLIREEKPVLVDFWAPWCSYCRRIGPAYEKIGEEYADSLAVGKINIDEEPQLAGAEGIKVIPTLVLFRNGKAVGSITAPGSKAEIDRFIQEALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CGV6</accession>
    <name>A0A174CGV6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">kpsM</name>
        <name evidence="11" type="synonym">tagG_1</name>
        <name evidence="11" type="ORF">BWLFYP14_02213</name>
        <name evidence="8" type="ORF">ERS852478_01917</name>
        <name evidence="10" type="ORF">GT712_17460</name>
        <name evidence="9" type="ORF">GT728_10750</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 15">BIOML-A1</strain>
            <strain evidence="10 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000023">
        <property type="protein sequence ID" value="MZL33664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000051">
        <property type="protein sequence ID" value="MZS90795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703542.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12334">
        <property type="protein sequence ID" value="CUO12334"/>
        <property type="gene ID" value="ERS852478_01917"/>
    </dbReference>
    <dbReference type="GeneID" id="66493877"/>
    <dbReference type="eggNOG" id="COG1682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="17"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO12334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS90795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX65848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="258" mass="30015" checksum="37AF7D2D291EA463" modified="2016-09-07" version="1">MKKYVDNFMQYRFLLSELVKKGIKLKYRRSYLGMIWSMLEPLLTMIVLTIVFGTLYGNTDRTFPVYILTGRLLYSFFSQSTKAALKSIRQNSAMIKKVYVPKYLYPLSSVLFNYVIFLISLIVLAMVSVILGVKPTFYLLQAPIALILILIMSYGCGMILATIGVFFRDMEYLWSVALMLVMYTCAIFYYPEKLLKSGWAWILKYNPLYCVIDIFRCSVFGKAMNIHYFAYALIFSVVAMVIGLFCFKKKQDDFILYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D2D6</accession>
    <name>A0A174D2D6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Periplasmic pH-dependent serine endoprotease DegQ</fullName>
            <ecNumber evidence="7">3.4.21.107</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">degQ</name>
        <name evidence="7" type="ORF">ERS852478_02096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.107" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19417">
        <property type="protein sequence ID" value="CUO19417"/>
        <property type="gene ID" value="ERS852478_02096"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="333"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="429"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO19417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="502" mass="53240" checksum="D8FFC997CA3523F5" modified="2016-09-07" version="1">MMNKDNRNDKIRKIAKKGLTLSLCAVLAGGLAAGSFEGVNKLAGWSGATTVEAASNKDETTLTYAKSEKKDADTSDSKSDTGKDTGSTAKGNLDVSEIASEALPSIVSITTKSVQEVQNYFGMYGMYGYAPQQQEQEVEGSGSGIIVGKNDDELLIATNYHVVEGADTLSVAFTDGNAVEASVKGFDEERDLAVVSVSLDDVKDDTMDAISIAKIGSSDDLKVGEQVIAIGNALGYGQSVTTGIVSAKNRRMDSDNNTVTDGSDDSSDGVNLIQTDAAINPGNSGGALLNMEGEVVGINSAKLASTEVEGMGYAIAISDVTDILQNLMNETSRDKLDDSEHGVLGIEGSSVSSEAVQMYGIPAGVFVKKVTEGGAADKAGLKANSVITEFNGKTVSSINQLIEYLSYYEPDEEVELTVQVPHGTSYKEETVKVTLDENTDADDSDDNDKDSKKSKKDSKKSSKDADEDVDEDTDSEDSMDSDDTEESENPFIQYFENQGFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D488</accession>
    <name>A0A174D488_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MarR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02818</name>
        <name evidence="1" type="ORF">ERS852478_02127</name>
        <name evidence="2" type="ORF">GT712_11525</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006858455.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20344">
        <property type="protein sequence ID" value="CUO20344"/>
        <property type="gene ID" value="ERS852478_02127"/>
    </dbReference>
    <dbReference type="GeneID" id="61435045"/>
    <dbReference type="GeneID" id="64113476"/>
    <dbReference type="GeneID" id="66881510"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO20344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS89685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="141" mass="16514" checksum="912936BA3AC6A3D3" modified="2016-09-07" version="1">MGAGTSAEEFFLKSINVESIFEFVERTDYLFLYSIKECVEKSDCHEGVYLSEVAEYMKLSIPETSKMVKSLENKGYIIWKLDEKKERTYLVLTNKAIELSNCQKEKMIEAYEKIISNIQEDDLAVTRCTLRKIRQLMEEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DII4</accession>
    <name>A0A174DII4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase YbjI</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybjI_1</name>
        <name evidence="1" type="ORF">ERS852478_02269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200667.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25254">
        <property type="protein sequence ID" value="CUO25254"/>
        <property type="gene ID" value="ERS852478_02269"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO25254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="267" mass="30466" checksum="38010E866DD43625" modified="2016-09-07" version="1">MIKLVASDLDGTLLLHKAQSLPEEIFSLIRQLEELGIMFVAASGRQYPNMTKLFAPVASEISYISENGALAVDHGEVLYQDSFDRKLAGEIISAILEKKDAEFTCSAKDYHYLMPKTKRFHDHMLYEVKNECRFVNSMEEMTAPIMKLAVFEPAGLTEESVKYWMDRFGKECVVVTSGNEWIDFIPFGTNKAKGIREYQKRYHISPEECIAFGDEYNDIEMLKAVKYGFAMEHSKEGVRAATSYMTKQVELVLEKLIRAKGKIEEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DKI7</accession>
    <name>A0A174DKI7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Excisionase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02241</name>
        <name evidence="3" type="ORF">ERS852523_04456</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000125">
        <property type="protein sequence ID" value="CUQ22764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002347229.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000125.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000025_gene941"/>
    <dbReference type="EnsemblBacteria" id="CUO24410">
        <property type="protein sequence ID" value="CUO24410"/>
        <property type="gene ID" value="ERS852478_02241"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ22764">
        <property type="protein sequence ID" value="CUQ22764"/>
        <property type="gene ID" value="ERS852523_04456"/>
    </dbReference>
    <dbReference type="GeneID" id="61927983"/>
    <dbReference type="eggNOG" id="ENOG5032S7G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038148">
        <property type="entry name" value="Tn1545/Tn916_Xis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015122">
        <property type="entry name" value="Tn916-Xis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09035">
        <property type="entry name" value="Tn916-Xis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004323">
        <property type="entry name" value="Tn916-Xis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO24410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ22764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="67" mass="7967" checksum="8D38478AE3DAF419" modified="2016-09-07" version="1">MNNTDVPIWEKYTLTIEEASKYFRIGEKKLRKLAEENLDAGWVIVNGNRIQIKRKQFEKIIDTLDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DMK0</accession>
    <name>A0A174DMK0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="2">dTTPase/UTPase</shortName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">maf</name>
        <name evidence="3" type="ORF">ERS852478_02271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705516.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25325">
        <property type="protein sequence ID" value="CUO25325"/>
        <property type="gene ID" value="ERS852478_02271"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO25325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="197" mass="21706" checksum="EF6F574AA60BCBD8" modified="2016-09-07" version="1">MRKIILASASPRRKELLERAGVDFEVLPASGDENRISDNPGEAVKQLASDKAASVIRTMKDSADGTIVIGSDTVVVFENVILGKPHDTEDAVNTLKKLQASTHQVYTGVSVWEKKEKVWTEHTFYESTDVTFYPVSDEEIREYVATGEPMDKAGSYGIQGLFGIYVKGINGDYNNVVGLPVARLFYEMKKSGINLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DNZ5</accession>
    <name>A0A174DNZ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Toxin A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">toxA_2</name>
        <name evidence="5" type="ORF">BWLFYP14_01578</name>
        <name evidence="4" type="ORF">ERS852478_02333</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO27174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381073.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27174">
        <property type="protein sequence ID" value="CUO27174"/>
        <property type="gene ID" value="ERS852478_02333"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018337">
        <property type="entry name" value="Cell_wall/Cho-bd_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01473">
        <property type="entry name" value="Choline_bind_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19127">
        <property type="entry name" value="Choline_bind_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51170">
        <property type="entry name" value="CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252862" evidence="3">
        <location>
            <begin position="36"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="Cell wall-binding" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO27174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="490" mass="54633" checksum="6BD74B4D03A84591" modified="2016-09-07" version="1">MQNVNRKFKIWGALLFLLFFAVGVSMYFTAANVQAATKTGFVTINGDSYYINKDGSKQKGWLELEGKKYYFNTKTGVQVKGWVTDSKGRKRYFSKQAGIMMTGWVTDSKDQKRYFNPSTGFMQTKWLTLKGKRYYFYSNSGVAACKTFLTDSKKNTRYFTSACYMLTGWTKNSSNEYRYFETEDGIMAKGFQTLDGKKYYFNTGSGKMAVGWTTIDGNKYYFDKETGVMATGDVTIDGQKYHFNSNGILSNTTSPTGSRTIKNYLAGALQPVGQALYVWGGGWNDSTRKGTSQTMTDFYNSQSSSYDYNNYRDLSTANRAKGFDCSGFVGWSAYQVMQSKSGVGSGYTVVSGEIGSYYKSMGWGSILTQANLASDDWTVYPGDVGYDSGHTWIILGQCADKSAVIVHSTPNAGVQIAGTPTPSGGYSSQAIALAQKYMSRYPGYTKYDYHTSSGNYIRRGNYLRWNRSTLSDPDGYMNMTADQILADLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DX56</accession>
    <name>A0A174DX56_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BWLFYP14_00135</name>
        <name evidence="6" type="ORF">ERS852478_02402</name>
        <name evidence="8" type="ORF">GT712_04450</name>
        <name evidence="7" type="ORF">GT728_02035</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">BIOML-A1</strain>
            <strain evidence="8 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL32014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381481.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30034">
        <property type="protein sequence ID" value="CUO30034"/>
        <property type="gene ID" value="ERS852478_02402"/>
    </dbReference>
    <dbReference type="GeneID" id="66494289"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO30034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL32014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS88362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="292" mass="33754" checksum="05FCE58CA75E4228" modified="2016-09-07" version="1">MKFIDKLERKFGNRGIENLTIYIIVSYVLGYALMYINPGALSMLSLNVSEILHGQIWRLVTWIIYPPSTSSALWFVIAILFFYYPISASLERTWGSFRFTVYILSGMIFTVISAFILYFITGGVLDAYLNGSQFSTYYISLSIFLAYALTYPDMKVLLYFVIPIKMKWMAIVYAALVVYDIVRYFMGGAWFMALPIIASLLNFIIFFLGTRNLNRYNPKEIHRRNQFKRAMGESKTVPFPGGSKSGEVTKHKCAVCGRTEKDDPNLEFRFCSKCNGNYEYCQDHLYTHIHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DZI0</accession>
    <name>A0A174DZI0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluD_3</name>
        <name evidence="7" type="synonym">rluD_1</name>
        <name evidence="7" type="ORF">BWLFYP14_00102</name>
        <name evidence="5" type="ORF">ERS852478_02434</name>
        <name evidence="6" type="ORF">GT728_01830</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO31022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL31973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704813.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31022">
        <property type="protein sequence ID" value="CUO31022"/>
        <property type="gene ID" value="ERS852478_02434"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="89"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO31022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL31973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="299" mass="33814" checksum="AD97174BBC83B53A" modified="2016-09-07" version="1">MQRILKYIISENTTPVTILDFLKKEGFSRHILSSMKNTPNTIILNGERGFGRSVLKPQDHLIVTVPETESGENIIRTKMDLNIIYEDEDILVINKPADMPVHPSAGNYENTLANGIAWYFAEKGEDFVYRCINRLDRDTTGALILAKNPLSAAILSVQMKKRQILRTYLALVDGLLPDSGTINAPIARMEGSVITREVNFGTGESAITHYERLAAGKEYSLAELHLETGRTHQIRVHMKYIGHPLPGDYLYNPDYRRINRQPLHSYQLEFTHPTTGKVMLFTAPLPIDFISAFYSNPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DZQ8</accession>
    <name>A0A174DZQ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">HTH-type transcriptional regulatory protein GabR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gabR</name>
        <name evidence="5" type="ORF">BWLFYP14_00114</name>
        <name evidence="4" type="ORF">ERS852478_02422</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060046.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30707">
        <property type="protein sequence ID" value="CUO30707"/>
        <property type="gene ID" value="ERS852478_02422"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO30707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="441" mass="50150" checksum="F7E694AE9A94B444" modified="2016-09-07" version="1">MELILDKNKKREHLYLEVFHYYRELIMEKKLPPGSRMPSLRKCSQELKLSRTTIENAYLQLAAEGYIISKAQSGYYVTDIADRQHTSVRKTEKHAQTPCRFDFASSGVDRESFRFDLWRRYIKSALRQDERLLSYGEPQGEADLRDTLADYVRERRNVLCSGEDIVIGAGIQSLLHILCPLLDQRRTVSFPNSSFVQGSTVFHDYGFQVDYRNKDCDIIYVSPAHMTKWGDIMPVSRRLELVNYSAAHGSLVIEDDFENEFVYLQKPTPSLFGLAGGQNVVYLGTFSRLLLPSIRISFMVLPPELSALYRKKADQYNQTASKAEQIALCQFIRDGHLAAQTRKLKRLYSVKLKALRSAVREVFGKDSQIQTGAAGTSLALTLSTTLTWQELQKKAQTNGLRLQLLREAPGKITLILSCSSMPVADFVPACKLLKNISQIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E2W9</accession>
    <name>A0A174E2W9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="3">6.3.5.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cobyrinic acid a,c-diamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cobB_1</name>
        <name evidence="3" type="synonym">cbiA</name>
        <name evidence="6" type="ORF">ERS852478_02427</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine = 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:26289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="ChEBI" id="CHEBI:58894"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobB/CbiA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.11" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053404.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30848">
        <property type="protein sequence ID" value="CUO30848"/>
        <property type="gene ID" value="ERS852478_02427"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="4">
        <location>
            <begin position="6"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="5">
        <location>
            <begin position="254"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="3">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO30848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="464" mass="51987" checksum="5C5B3A280DC3F8AF" modified="2016-09-07" version="1">MDIPRILLAAGASGSGKTLITCGLLQALVNRKMKVASFKCGPDYIDPMFHSRVIGTKSRNLDTFFTDAETTRYLLGKNAADCDIAVMEGVMGYYDGVGGISTKASAYDLADTTDTPVILVVNSRGMSISLAAYIKGFMEYKEKSHIKGVIFNQMSPMLYPRMKKLVEEQLEVEVLGYVPKVEDCVIESRHLGLVLPEEISDLRERLQKLAGILEDTLEIDRILGLAKNAEELQVPESLIQKDRTYGYCLPQKLRIGVAKDEAFCFFYEDNFRLLQEMGAELVDFSPIHDEHLPADLDGILLYGGYPELNGEALERNASMKEEIAQAVKQGMPCMAECGGFMYLHEQMEDMGGVFRKTCGVIPGKCFRTPRLTRFGYITLTARKPVFGRSAEEIGEIPAHEFHYFDSENCGSDFHAAKPLSKRGWDCIHSSSNLLAGYPHIYYYGNPQIPRAFLMKCLEYHNKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E5C3</accession>
    <name>A0A174E5C3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable endopeptidase p60</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Putative endopeptidase p60</fullName>
            <ecNumber evidence="4 5">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">iap_5</name>
        <name evidence="5" type="synonym">iap_1</name>
        <name evidence="5" type="ORF">BWLFYP14_00095</name>
        <name evidence="4" type="ORF">ERS852478_02441</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="4 5"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO31230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704825.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31230">
        <property type="protein sequence ID" value="CUO31230"/>
        <property type="gene ID" value="ERS852478_02441"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033732836" evidence="2">
        <location>
            <begin position="17"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="73"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO31230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="171" mass="17401" checksum="8B3B948A6B8BC320" modified="2016-09-07" version="1">MKKSLWLVLVLGLAFAAQGCGFDPTIDSSVMIVKVTPTPEVTPTPEASEATPTPEATPTPAAEQTASGVKVEVKSGTYYASSELNLRSDASSDADLISSVAAGTQLNSTGVCENGWIRVDYNGQTCYASGDFVTTTAPAADAGETAADTSADAGETAADTSADTSYDESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E6H4</accession>
    <name>A0A174E6H4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV secretion system component VirD4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993989.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32019">
        <property type="protein sequence ID" value="CUO32019"/>
        <property type="gene ID" value="ERS852478_02450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032689">
        <property type="entry name" value="TraG-D_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12696">
        <property type="entry name" value="TraG-D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TraG-D_C" evidence="1">
        <location>
            <begin position="29"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO32019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="231" mass="27042" checksum="FB3D5ED01329DF21" modified="2016-09-07" version="1">MLATLFTSFLSIKLVRLADRTEERVLPVPISFILDEFPNIGVVPDFKKKLATARSRRIGMSILFQNIPQLQNRYPDNQWEEILGGCDFSIFLGCNDMTTATYYSDRIGEITVSVASIRKNFFTIRATDYVPEYSESRSIGKRQLLLPDEILRYPLDQGILIIRGHNVLRFKKMDYTEHADAGKLKMEKVVDHIPDWYRKWEKQQQEFQILDEQVYEAMDSEFCLPRNLDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EBQ9</accession>
    <name>A0A174EBQ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">Int-Tn_4</name>
        <name evidence="6" type="ORF">ERS852478_02535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO34208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200767.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34208">
        <property type="protein sequence ID" value="CUO34208"/>
        <property type="gene ID" value="ERS852478_02535"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008907">
        <property type="term" value="F:integrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075713">
        <property type="term" value="P:establishment of integrated proviral latency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044826">
        <property type="term" value="P:viral genome integration into host DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004191">
        <property type="entry name" value="Integrase_Tn916-type_DNA-bd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02920">
        <property type="entry name" value="Integrase_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="SSF54171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0229">DNA integration</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1179">Viral genome integration</keyword>
    <keyword evidence="4" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="186"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO34208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="399" mass="46678" checksum="D13535BAB6B26893" modified="2016-09-07" version="1">MSGKRRDSKNRVLRNGESQRRDGRYAFKYIDTTGKPQFVYSWKLEKTDKTPQGKRDDLSLREKEKQIMKAIDDEIVPRGGEMTVLELVKKYLMQKTGVRHNTEANYNFVLNIIKKEDFGKKRIDKVKLSDAKCWLIKLQQDGRGYSSIHSIRGVVRPAFQMAVDDDLIRKNPFEFQLATVVVNDSVTREAITRKQERAFLEFVVNDKHFCRYYEGIFILFKTGLRISEFVGLTLSDLDMQNRKISVNHQLQRKRNMEYVIEDTKTSCGTREIPMTDEVYECFQRIISSRKKPRVEPIVGGKCGFLYLDKNDMPMVALHWEKYFQHICEKYNSIYRVQMPKVTPHVCRHTFCSNMAKSGMNPKTLQYLMGHSDISVTLNTYTHIGYDDAKEELKRVVNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EEW9</accession>
    <name>A0A174EEW9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 15" type="primary">gpsA</name>
        <name evidence="15" type="ORF">ERS852478_02590</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703894.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36354">
        <property type="protein sequence ID" value="CUO36354"/>
        <property type="gene ID" value="ERS852478_02590"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="13">
        <location>
            <begin position="3"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="14">
        <location>
            <begin position="178"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="253"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO36354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="339" mass="36637" checksum="85EB0CBE2A3E5D21" modified="2016-09-07" version="1">MAKISVLGAGSWGTALSILLYNNGHEVILWSALGEEITTLREKREHVSKLPGVKIPEPIDITIDLERSLRDADVAILAVPSPYTRSTCKRMAPFVKNGQKIVNVAKGVEEKTLLTLSEIIEQELPQANVSVLSGPSHAEEVGKGLPTTCVVSSHQRETAEYLQGIFMSPVFRVYTTPDMLGVELGAALKNVIALAAGTADGLGYGDNTKAALITRGIAEISRLGVKMGARMETFYGLSGIGDLIVTCASVHSRNRKAGYLMGKGYTMEQAMAEVKMIVEGVYSAKAAKELAEKYDVEMPIITEINKVLFEGKSAAEAVIDLMVRDKKVETPMLPWEDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EGM0</accession>
    <name>A0A174EGM0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200787.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35345">
        <property type="protein sequence ID" value="CUO35345"/>
        <property type="gene ID" value="ERS852478_02557"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8XY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045714">
        <property type="entry name" value="DUF6070"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19546">
        <property type="entry name" value="DUF6070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO35345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="415" mass="47843" checksum="273EFB92E987DCB0" modified="2016-09-07" version="1">MEIIDMITKRKLKKMMSVLFISGCFFIGNTKCKGADLEYISQETANYAVQERGYDLPVDEVVKEEAIEDCKNVMNQMKVIYQKADKGTSSNIVVSETVMEEMQEVLKEKNVPVITSAPYSNMANYSKMEEFLFRAEQDLTGDIVLYRINRDGGIERLKFNYDGTDMYLLAAKAVWGMNDNPSIVYVSYTRIEEWKYTEKGWFGYTLCVPKYPEVSEAVDGSSMIRIKPLSDECREVSKRCVYLLGYQGNNLLCSDWDRSDMEGLDYNGLYEYLYRMKYGERYEFSGNSSGIPAEEFENLIMEFLPITADQIKKWAVFDSEHQTYDWERLGCLNYSPTYFGTSLPEVVEIRDSGEGNSVLVVDAVCDTFICNDAVITSELTVKFNDDKSFKYMGNKILNNGTKEVPKYQYRIKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EH21</accession>
    <name>A0A174EH21_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Signal peptidase I</fullName>
            <ecNumber evidence="4 5">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sipT_2</name>
        <name evidence="8" type="synonym">sipT_1</name>
        <name evidence="8" type="ORF">BWLFYP14_02467</name>
        <name evidence="7" type="ORF">ERS852478_02599</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 5"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000050">
        <property type="protein sequence ID" value="VUX66095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703909.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36587">
        <property type="protein sequence ID" value="CUO36587"/>
        <property type="gene ID" value="ERS852478_02599"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="6">
        <location>
            <begin position="32"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO36587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="201" mass="22276" checksum="3000E451487E8F63" modified="2016-09-07" version="1">MNIRKWKDSPALKETRDMLEIKLEDKKVRGILNWIFQIAVVLIFGILAGIALFQSVTVQESTMEPTLQVGERFFVNRAVYKVSSPERGDIIVYKTSGSDDAALHIGRVIGLPGETVQISNGAVLINGEVYNENKNFPEISNAGLASDGVSLESGEYFVLGDNRNNSEDSRYGDIGNINKKYIVGKVWFVISPKDKFGFLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ETZ0</accession>
    <name>A0A174ETZ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">H-34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO39445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580989.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39445">
        <property type="protein sequence ID" value="CUO39445"/>
        <property type="gene ID" value="ERS852478_02682"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013486">
        <property type="entry name" value="SpoIID/LytB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013693">
        <property type="entry name" value="SpoIID/LytB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30032:SF4">
        <property type="entry name" value="PTHR30032:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08486">
        <property type="entry name" value="SpoIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="SpoIID" evidence="2">
        <location>
            <begin position="36"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO39445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="277" mass="31392" checksum="ED627DD1092C919D" modified="2016-09-07" version="1">MRKSFFPGTTGIFALFFVPYIVTIIFNGANTTLINKKFNVEMLLPVIVSSQIEDKYELETIKAQTIIARSNFYRTMKEEKNLAITLCQIKEEMEGKSLACVILQNKYEKAVTETEGKVIVWNKELKLVPYHELSAGQTRDGMEVFHNEDDSYLRSVHSLVDKNAKDYLNSVYINKNILPERIEIKSRDSAGYVTEILADGKVLEGEAFRKGMGLTSSNFTIQKSGKEVRFLCRGKGHGLGFSQYGGNEMAKESANAKEILQYYFPEMDVLNIKSVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EVQ0</accession>
    <name>A0A174EVQ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proline--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="8">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">proS</name>
        <name evidence="10" type="ORF">ERS852478_02712</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200855.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40589">
        <property type="protein sequence ID" value="CUO40589"/>
        <property type="gene ID" value="ERS852478_02712"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="SSF64586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="45"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO40589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="479" mass="54770" checksum="0D124FC2B4AB038A" modified="2016-09-07" version="1">MANNKKLVEAITSMEEDFAQWYTDVVKKAELCGYTSVKGCMAIKPAGYAIWENIQHELDRRFKETGVQNVYMPIFIPESLLQKEKDHVEGFAPEVAWVTHGGLDPLQERLCVRPTSETLFCDFYAKEIQSHRDLPKVYNQWCSVVRWEKTTRPFLRSREFLWQEGHTAHATAEEAEERTIQMLNLYADFCEEVLAIPVIKGQKTDKEKFSGAEATYTIESLMHDGKALQSGTSHNFGDGFARAFGIQYTDKENKLQYVHQTSWGMTTRMIGAIIMVHGDNSGLVLPPRIAPTQAVIIPIQQRKEGVLEKADEMFAALKAAGVRVKVDDTDKSPGFKFAEQEMRGIPIRIECGPKDIENGQAVICRRDTREKYTVTFDELVEKVQEILETIQKDMLERARKHRDSHTYVATNYEEFKDTIVNKPGFVKAMWCGDRACEDKIKEDVQATSRCMPFEQEHLSDVCVCCGKPAKKMVYWGRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EXU5</accession>
    <name>A0A174EXU5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator SlyA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42932">
        <property type="protein sequence ID" value="CUO42932"/>
        <property type="gene ID" value="ERS852478_02784"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO42932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="182" mass="21566" checksum="AD793AA4114D0554" modified="2016-09-07" version="1">MDSNLTIIWLCNSMGTDFRRCGEIDEEMKQKLNEMHVGRLIHILSHTMKRHNPAEVMENDDLTTMQKHVLKFILLETMHRDLYQKDIEEEFQIRKPTVTGILKLMEKNGYIYRESAKQDARLKQIIPTEKAEKIRPAILKSIEEGEAKMLRGIPKEDVELCKQVLWQMYENRKKSCDSRNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F7V8</accession>
    <name>A0A174F7V8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized hydrolase yutF</fullName>
            <ecNumber evidence="1">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yutF</name>
        <name evidence="1" type="ORF">ERS852478_02849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44906">
        <property type="protein sequence ID" value="CUO44906"/>
        <property type="gene ID" value="ERS852478_02849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO44906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="281" mass="31150" checksum="79484616DCEE11E3" modified="2016-09-07" version="1">MTIKSNIVKKEERNINNMQNNLASMIKEKKLFLLDIDGTVALGSELLPGAADFLQTVKENGGIFRFLTNNSSKAASDYVEQFHDWGIETTEEEFITAGIYARDFMKKYYGNEKILVAATETYCSELRKAGLNITDQAGDDVDCVLCAYDTELTYEKLVQVCKQLTETKVPWFATNPDLRCPIDFGMIPDCGSICRMITASVGREPEYIGKPAPGMVYACLEETGCTPKQTLLIGDRIYTDMECGKLAGIDSCLVLTGEASAEEWKNGFRCQSLGKLAGYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F998</accession>
    <name>A0A174F998_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plasmid recombination enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmid mobilization pre family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46932">
        <property type="protein sequence ID" value="CUO46932"/>
        <property type="gene ID" value="ERS852478_02916"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001668">
        <property type="entry name" value="Mob_Pre"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01076">
        <property type="entry name" value="Mob_Pre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="214"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="343"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO46932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="472" mass="55487" checksum="2DF14791F98E009F" modified="2016-09-07" version="1">MMKRTISGMIGAGSLAHNRRDFVAENVDPDRVQLNICYKNENLKEVYKELFDDAAERYNVGKRKDRQIANYYEKIRQGKQEKLFHEIIFQIGNREDMAVGTLEGNLAVKVLDEYVKDFQKRNPTLRVFSCYLHQDEATPHLHIDFVPYVTNWKGKGMDTRVSLKQALKSLGFQGGNKHDTELNQWINHEKEVLAEIAKQHGIEWEQKGTHEEHLDVYNFKRKERKKEVQELEKEKEYLTVENEELTAQIAESRADIQILKDDKKQAIREKQEAEQRAEDAEKELKSLEDRRNVLQPIMDNASKEIKEYGMIKTFLPEAGTFERAAPYRENKIKPLFIKMKNQIAALAGKVVELNKTIESWKNKYQKSTEKCDDIQKQLDDVRKENGKLSNDNQRLQEISDRYDRVVRILGSETVEDVVQQDIKEQRTLEEKRRMEQMPKGSVLKQLEWATQKSQIENQQRKKNKTKYKGLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F9E0</accession>
    <name>A0A174F9E0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ugpQ_2</name>
        <name evidence="2" type="ORF">ERS852478_02844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200963.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44765">
        <property type="protein sequence ID" value="CUO44765"/>
        <property type="gene ID" value="ERS852478_02844"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="9"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO44765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="247" mass="27950" checksum="AC736BC8CAA89811" modified="2016-09-07" version="1">MTETTKRTTKVWAHRGASGYRPENTLEAFELAIRQGADGIEMDVHTSADGELIVMHDENVDRVTDGTGLIKDMTLAQLKELKVSTPAEPSGIYHIPTLAEVLELMRTTDMMINIELKNSICFYPGMEEKILKLVKEMNMEDQLIYSSFNHYSLLQLKQLNDHVQTGILFSDGWVNPAMYAKNLGINAVHPAVYHLKYPQFIKEVKRAGLKMHVWTANKPEHIQLVKDAGAEAVITNYPDRAIEIIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FPD2</accession>
    <name>A0A174FPD2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription-repair-coupling factor</fullName>
            <shortName evidence="9">TRCF</shortName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">mfd</name>
        <name evidence="12" type="ORF">ERS852478_03048</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379954.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51571">
        <property type="protein sequence ID" value="CUO51571"/>
        <property type="gene ID" value="ERS852478_03048"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="578"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="748"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO51571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1105" mass="127383" checksum="158CDACD343FC221" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FR95</accession>
    <name>A0A174FR95_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">FMN reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.5.1.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nfrA2</name>
        <name evidence="2" type="ORF">ERS852478_03044</name>
        <name evidence="3" type="ORF">GT728_15365</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.5.1.39" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000043">
        <property type="protein sequence ID" value="MZL34535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379958.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51366">
        <property type="protein sequence ID" value="CUO51366"/>
        <property type="gene ID" value="ERS852478_03044"/>
    </dbReference>
    <dbReference type="GeneID" id="66494653"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052874">
        <property type="term" value="F:FMN reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052873">
        <property type="term" value="F:FMN reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008752">
        <property type="term" value="F:FMN reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO51366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="172" mass="18738" checksum="6F190CD0B0D911AC" modified="2016-09-07" version="1">MNETIKNLLERRSVRGYKEDLVPEEVLNEILEAGEYAPSGMGQQGTLMVVTQNPELVAKLSKMNADVMGTESDPFYGAPTVVVVFADSNMPTCVENGSLVMGNLMNAAHALGVDSCWIHRAREVFASEEGKALKAEWGVPESYVGIGHCVLGYRSGEYPKAKARKDGFVIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FWD1</accession>
    <name>A0A174FWD1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell division ATP-binding protein FtsE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsE_1</name>
        <name evidence="5" type="ORF">ERS852478_03139</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO54513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201188.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54513">
        <property type="protein sequence ID" value="CUO54513"/>
        <property type="gene ID" value="ERS852478_03139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO54513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="221" mass="24423" checksum="BC98B432426C2EBB" modified="2016-09-07" version="1">MSVLQTIDLKKYYGTKPNITRALDGVNFSVNDGEFVAVVGTSGSGKSTLLHMMGGLDTPTSGNVIVRDKELSKMNDEQLTIFRRRNIGFIFQNYNLVPILNVYENIVLPVELDGDTVDQKFLDEIVHLLGLEDKLKNMPNNLSGGQQQRVAIARALITKPAIVLADEPTGNLDSKTSAEVLGLIKRTSAEFRQTVVMITHNDDIARLADRIVRIEDGKIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FWW9</accession>
    <name>A0A174FWW9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_00686</name>
        <name evidence="2" type="ORF">ERS852478_03149</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO54782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000015">
        <property type="protein sequence ID" value="VUX62937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54782">
        <property type="protein sequence ID" value="CUO54782"/>
        <property type="gene ID" value="ERS852478_03149"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="80"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO54782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX62937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="182" mass="21933" checksum="91290C894603FD59" modified="2016-09-07" version="1">MKKVNLRDLYPDVYKNDYFVEVTEDVLETIRAAERAEAAYDRRMYRYKAYYSLNCDNGIENAILMKPQTPEMLLEEKQLREQLYAAVMALPEKQAKRIYARYYLGMRVSEIATAEGVDQSRVRDSIRRGLKQLAKYFRIELQMGRKVSKCFWHRALRPICTLVFFEQRKYNKPYWRETIWII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G335</accession>
    <name>A0A174G335_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Energy-coupling factor transporter ATP-binding protein EcfA2</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ecfA2</name>
        <name evidence="9" type="ORF">ERS852478_03167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cell membrane</location>
            <topology evidence="2 6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55249">
        <property type="protein sequence ID" value="CUO55249"/>
        <property type="gene ID" value="ERS852478_03167"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030946">
        <property type="entry name" value="EcfA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04521">
        <property type="entry name" value="ECF_ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="289"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO55249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="358" mass="39489" checksum="B404C253C8D9504B" modified="2016-09-07" version="1">MSIELKNVTYTYSPGTAYEIHALKDINLSIPDGQFIGIIGHTGSGKSTLIQHFNALIRPTSGTITYNGEDIWGEKYDRRALRSEVGLVFQYPEHQLFENDVLSDVCFGPMNQGLSREEAEVEAKKALQHVGFKEKNFSKSPFELSGGQKKRVAIAGVLAMNPKILILDEPTAGLDPKGRDDILDQIAELHKVRGITIILVSHSMEDIAKYAERLIVVNDGEIAYDDAPKAVFAHYRELEAMGLAAPQITYIMHALKEKGLDVDVTATTVDEAKENILAVLRKCNLGKLSGNRQSVSDSQSKKENAKAETLISEMEADLTKDGTKESHSDVPDEDLSIQKETMDKKSAEQEENEGGQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G6S1</accession>
    <name>A0A174G6S1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO58192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201255.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58192">
        <property type="protein sequence ID" value="CUO58192"/>
        <property type="gene ID" value="ERS852478_03253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO58192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="140" mass="15789" checksum="03FBA38D732E096F" modified="2016-09-07" version="1">MKSLPELIHDYKSGVPGTDAKILQRMQPLIKGTAAKIHCMEREDSQQELYLSLLQAIPYLNEDSSEGECVKYIQTVIQNRYKSLCRCNLSAPETDDIDSSTAILTAPDTFDDSYYDIAAFIASLPEKSIKQEIMTLFFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G842</accession>
    <name>A0A174G842_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">crcB</name>
        <name evidence="12" type="ORF">BWLFYP14_03478</name>
        <name evidence="10" type="ORF">ERS852478_03260</name>
        <name evidence="11" type="ORF">GT728_12935</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO58594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000032">
        <property type="protein sequence ID" value="MZL34082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58594">
        <property type="protein sequence ID" value="CUO58594"/>
        <property type="gene ID" value="ERS852478_03260"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO58594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL34082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX67203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="121" mass="12760" checksum="7320D6F080CFBA3D" modified="2016-09-07" version="1">MMNCLAVGLGGFAGAVLRYLIGLIPTGETMIFPVKTFCINVIGCIVIGAITVLAAKLSVPPRMILFLKVGVCGGFTTFSTFALESSDLIRDGHMGIALCYVLLSVLVGVLAIFAVEYLTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GER8</accession>
    <name>A0A174GER8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative accessory gene regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03305</name>
        <name evidence="4" type="ORF">GT728_14685</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000039">
        <property type="protein sequence ID" value="MZL34410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381202.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60047">
        <property type="protein sequence ID" value="CUO60047"/>
        <property type="gene ID" value="ERS852478_03305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006741">
        <property type="entry name" value="AgrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04647">
        <property type="entry name" value="AgrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0673">Quorum sensing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO60047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="194" mass="21649" checksum="3C59632D0419C6D5" modified="2016-09-07" version="1">MEKCTDTVVNWMIRCNAINEADKELYKYALYSFFLLVSPLILAGVIGFGLGSVKHGVALIFPFVVLRKFSGGYHAKNLHTCILGSGFLLFLCIMLSMHVQCDLKLAIATVIASVSLITFSPIDSENRRLDTNEKRTYKKTTVFFVILFGLLDIALFLLGKYIYTICFSVGILLTAGLQVPCIVKKMCKSTKNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GFZ5</accession>
    <name>A0A174GFZ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201344.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61484">
        <property type="protein sequence ID" value="CUO61484"/>
        <property type="gene ID" value="ERS852478_03344"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="192"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO61484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="281" mass="33458" checksum="8C0C6338FB47BE81" modified="2016-09-07" version="1">MESENYVYKKEIDWSTLMEGFTLPLDNQVIFLRNMENFLQRGQSKIIHFFMNGKTYDAKIVNMNNSVEKRKKDAYQIRYPRNGELSQALQQYFFKSMSYIKMIRESRDPKDRSYIKVPDGLKEYLAIYTTEYEDTFLLEPIAQDDFQVMKKAIQGMRERTVENEIEYEMEDKSSGIEKKLQIVKIRKLNRKIGENLKLLYGYRCQICGQVIGEKYGSHIAEAHHIDYFVNSLNNDANNQMIVCPNHHSVIHDANPVFDRRRMVYRFDNGVEERIRLNKHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GPB9</accession>
    <name>A0A174GPB9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO62770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62770">
        <property type="protein sequence ID" value="CUO62770"/>
        <property type="gene ID" value="ERS852478_03384"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO62770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="312" mass="34804" checksum="30EC85BF8E9BD18E" modified="2016-09-07" version="1">MSKIRKKKIKKTNILLGFICILLAVLLGFILVTSYKSEQKESRHLSEIADDQQSGIEDYEAVKERAKELEEISSEEAEDTEDTKDTEKTDTADTEDADKTEDTKDKTTAASGIVCWGDDLINGEESNTYSYMTVLQKLLTDNGYNMTVINKTLQGGGTLSMMKMAGVSDETIQSYITKHQQAANGAQLNVTETGIRDLTEEQTTRNDMDCIPVIFMGYYGGWNHDPAELADQQEQILNTFQNKNQFIVVGTRPMDGSVTSEALDQVLSQKWGEHYISLADVTAQPSSTYEAQQAMAEAILQKLQELNYISKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GRV2</accession>
    <name>A0A174GRV2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter glutamine-binding protein GlnH</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Sulfate starvation-induced protein 7</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Transporter substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fliY_3</name>
        <name evidence="8" type="synonym">glnH</name>
        <name evidence="8" type="ORF">BWLFYP14_02336</name>
        <name evidence="5" type="ORF">ERS852478_03467</name>
        <name evidence="7" type="ORF">GT712_16595</name>
        <name evidence="6" type="ORF">GT728_16120</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">BIOML-A1</strain>
            <strain evidence="7 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708207.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65304">
        <property type="protein sequence ID" value="CUO65304"/>
        <property type="gene ID" value="ERS852478_03467"/>
    </dbReference>
    <dbReference type="GeneID" id="66493940"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252881" evidence="3">
        <location>
            <begin position="29"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="4">
        <location>
            <begin position="49"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO65304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL34677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS90633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX65966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="330" mass="35662" checksum="67A39EE8948B4D0E" modified="2016-09-07" version="1">MKKKILAVLLATGVAATTLLGGSILVSAADDGGNTAQARTLDEIKKDGKIKIGVFSDKNPFGYVDENGDVQGYDIYFGKRLAKDLLGSEDDAEFTYVEAASRVEYLQSAKVDVILANFTVTDDRAEKVDFALPYMKVALGVVSPDDALIKDVKDLEGKKLIVVKGTTAETYFTDNYPDIELVKFDEYQEAYDALLDGRGDAFSTDNTEVLAWAQQNEGFSVGIESLGDIDTIAPAVQKGNTDLLNAINDEIKSLADEQFFHKDFEETLKPVYGDNINPDDLVVEGGVVDSEEKAEDADAAATEDSDAASDDTKDAETTEEPEETEAADAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H2W9</accession>
    <name>A0A174H2W9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201448.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68581">
        <property type="protein sequence ID" value="CUO68581"/>
        <property type="gene ID" value="ERS852478_03578"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO68581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="115" mass="13561" checksum="966CDF35FF08ED68" modified="2016-09-07" version="1">MIKKNFKGRCRKWKLKKCKDVMRAYSDIQAAYAERLEKDDGVKEFQCNVLLDGLEEGEYTSDFLCVKADGDFMVRECVERKFLMKPRTVKLLDASRDYWLRHGVKDWGLVIDAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H3C1</accession>
    <name>A0A174H3C1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA interferase</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ndoA_3</name>
        <name evidence="4" type="ORF">ERS852478_03554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PemK/MazF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006857263.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67826">
        <property type="protein sequence ID" value="CUO67826"/>
        <property type="gene ID" value="ERS852478_03554"/>
    </dbReference>
    <dbReference type="GeneID" id="61431746"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO67826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="118" mass="13082" checksum="881CA47648C0DA77" modified="2016-09-07" version="1">MERIIKRGDIYYAELNPVIGSEQGGTRPVLIISNDIGNKHSPTVIIAAITSRVHTKAKLPTHTAVSNYEGLDKDSVILLEQIRTIDKQRLKQYMGMMPNSIMARVNKALAISVALKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HAW2</accession>
    <name>A0A174HAW2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PLDc_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_03691</name>
        <name evidence="9" type="ORF">ERS852523_03755</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
            <strain evidence="9 11">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO72052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000063">
        <property type="protein sequence ID" value="CUQ04865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008393108.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72052">
        <property type="protein sequence ID" value="CUO72052"/>
        <property type="gene ID" value="ERS852478_03691"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ04865">
        <property type="protein sequence ID" value="CUQ04865"/>
        <property type="gene ID" value="ERS852523_03755"/>
    </dbReference>
    <dbReference type="GeneID" id="15230407"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="7">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO72052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUQ04865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="67" mass="7724" checksum="13317805509F916E" modified="2016-09-07" version="1">MNNVTEFLPFLVPLVISELALLAYTLYHILTHKSYKRGNRTLWLIVVIVGMQFIGPILYFLLGKEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HB26</accession>
    <name>A0A174HB26_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, y4mF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO70239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_049946900.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000072.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70239">
        <property type="protein sequence ID" value="CUO70239"/>
        <property type="gene ID" value="ERS852478_03633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO70239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="236" mass="26779" checksum="50AC19A325F65A0C" modified="2016-09-07" version="1">MVDTQKVGAFIAQCRKEHNWTQKELGEKLGVTDKAVSKWENGRSFPDITLLESLCETFDITVSELLSGKKIESEDYKRETERLLIQCIGEKRLRGFQIGIYLLGLVTIILGGIGFGIWGTHISWKIGSVPIKWILLAAALITFGVMAYFDRNLPGKNYRSSIIWLECIVEAFTLACIFGNSIISFWDIDNMTESIVFILITAVIMLCLFAARIIAARTNREEYEMQKNADKHETEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HCT7</accession>
    <name>A0A174HCT7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381436.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70960">
        <property type="protein sequence ID" value="CUO70960"/>
        <property type="gene ID" value="ERS852478_03654"/>
    </dbReference>
    <dbReference type="GeneID" id="66494350"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO70960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="327" mass="37503" checksum="985E4EEE1A2D954A" modified="2016-09-07" version="1">MKGSHRIIVESRKVKYDFVIHRNITIITGDSGSGKTVLIDLIHDYGRYGADSGVFLSCDCPCKVIDSEDWERKIEETTGSIIFIDEGNRFLVSKKFAQLVQGSDNYFVLATREKLPALPYSVSEIYGFRKSGKFHDAKQKYNEIYHLYGEISEEKNINPKLVITEDSNSGFEFFKEMSRQKGVNCFSAGGKSNIIRQLEQRPNEEGTILVIVDGAAFGSEMKDISECIKTQGNIVLYAPESFEWLLLSTKEIPEVKVETILQNPEEYIDSKEYVSWERYFTDLLIESTSKNFIWAYSKKRLTKAYFAPRIVNAVKTIMKLVDWEKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HDF3</accession>
    <name>A0A174HDF3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000045">
        <property type="protein sequence ID" value="CUO72864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72864">
        <property type="protein sequence ID" value="CUO72864"/>
        <property type="gene ID" value="ERS852478_03719"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="208" mass="22987" checksum="14A2F9F0E83821BA" modified="2016-09-07" version="1">MILGFLYTFALIAYAGGEVDAIEFSTYENIWTLINALQTVAYAVLISVMFSTFIIKEYAGKLNLLLFTYPVDKSTLLKAKVLLVAFSGIGGMLLGSALIFLIFFITERIFPLVPDTFSFGNIIKIWSELLLCSVYALCVGIVATKIGFIKMSVQTTIVSAIIIASCSANVISTMSYTNFPFLFLWGIMAIISIISYCNIVHKTIRMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HIK1</accession>
    <name>A0A174HIK1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">arlS</name>
        <name evidence="10" type="ORF">ERS852478_03763</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000047">
        <property type="protein sequence ID" value="CUO74061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201515.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74061">
        <property type="protein sequence ID" value="CUO74061"/>
        <property type="gene ID" value="ERS852478_03763"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="112"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="173"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO74061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="386" mass="43145" checksum="B7FC186CEC174675" modified="2016-09-07" version="1">MKFYSEKLSPRRLSLQWRLTLLISGLVITACALMYFFISRSAVTGLEGISDYVVLVTPDNSNPISINVDPKILIPDLENQIQNTKNNFLFQSMIATGIIILLSSICTWFVTRRALTPLRRFSDRIRQVQAQNLSEPLEVPLSEDEISRLTRSFNDMLARLDNAFSAQKRFVASAAHELRTPLAVMQTNLEVFYKKPEHAPQEYDRLFTMLQEQTGRLSHLAEILLDMTGLQTVERSDTISLAALTEEVFCDLDPVAEKHQVRLIQTDGDCTVTGSYILLYRAVYNLVENAIKYNRPSGSVTVSIHTAESAVLEVTDTGIGISPENQEKIFDPFYRVDKSRSRAMGGAGLGLALVSEIARQHNGQVKVTQSSEKGSTIALMLPVTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HK69</accession>
    <name>A0A174HK69_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000046">
        <property type="protein sequence ID" value="CUO73548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379879.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000113.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73548">
        <property type="protein sequence ID" value="CUO73548"/>
        <property type="gene ID" value="ERS852478_03743"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50346TK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO73548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="71" mass="8129" checksum="48D5382C9A0E3A4C" modified="2016-09-07" version="1">MSKVVKLSSVMEREEKLKEIYEGLEEIKDQLTALIDEYEEEETHTGKADELIEALDALEDASETIEDVLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HM85</accession>
    <name>A0A174HM85_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coenzyme F420-reducing hydrogenase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000048">
        <property type="protein sequence ID" value="CUO74397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993807.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74397">
        <property type="protein sequence ID" value="CUO74397"/>
        <property type="gene ID" value="ERS852478_03774"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007516">
        <property type="entry name" value="Co_F420_Hydgase/DH_bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045220">
        <property type="entry name" value="FRHB/FDHB/HCAR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007525">
        <property type="entry name" value="FrhB_FdhB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31332">
        <property type="entry name" value="PTHR31332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04432">
        <property type="entry name" value="FrhB_FdhB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04422">
        <property type="entry name" value="FrhB_FdhB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FrhB_FdhB_N" evidence="1">
        <location>
            <begin position="46"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="FrhB_FdhB_C" evidence="2">
        <location>
            <begin position="129"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO74397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="368" mass="41860" checksum="83C1C79990EB7AB2" modified="2016-09-07" version="1">MIDGGFPNVDVKKGESLEFYHSVCPVFYYKGKQKHDIWGNIEKALIGYSSNKKIRFKAASGGALTEICCYLLENKKVDAIIHTTYDPDDQTKTISCVSTTVEEVISRCGSRYGISVPLKDILQIVQSDKKYAFVGKPCDVMALRRYLNKNEKLTKNIIYLLSFFCAGEPSVNAQDELLKKMGTSRQGCDTLVYRGNGWPGFTTVNTKDGRELKMEYKVAWGQYLGRDIRYICRFCMDGTGELADIVCADFWQLDNNNHPDFSEHEGRNIIIARNELGKQLLDATVKSGRINVEEDFTTKIDSEFYLYQPAQLKRKGTMKTTITAMKLCGRDTPKYSKSFLNKYASHVDLKVKFDFFIGIIKRVIKGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HMA7</accession>
    <name>A0A174HMA7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rmlA1_2</name>
        <name evidence="7" type="ORF">ERS852478_03775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="CYZN01000048">
        <property type="protein sequence ID" value="CUO74417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704440.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74417">
        <property type="protein sequence ID" value="CUO74417"/>
        <property type="gene ID" value="ERS852478_03775"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO74417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="298" mass="33465" checksum="7AA92A9278674895" modified="2016-09-07" version="1">MKGIILAGGSGTRLYPLTKVTSKQLLPIYDKPMIYYPMSVLMNAGIRDILIISTPQDTPRFENLLGDGHQFGVNLTYAVQPSPDGLAQAFIIGADFIGDDSVAMVLGDNIFAGHGLKKRLQAAVQNAENGKGATVFGYYVDDPERFGIVEFDKNGKAISIEEKPEHPKSNYCVTGLYFYDNRVVEFAKNLKPSARGELEITDLNRIYLEDGTLNVELLGQGFTWLDTGTHESLVDATNFVKTVEQHQHRKIACLEEIAYLNGWICRDELMEVYEVMKKNQYGQYLKDVMDGKYQEHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HUG9</accession>
    <name>A0A174HUG9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000057">
        <property type="protein sequence ID" value="CUO76495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76495">
        <property type="protein sequence ID" value="CUO76495"/>
        <property type="gene ID" value="ERS852478_03832"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO76495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="302" mass="35416" checksum="E2359C3A9883452C" modified="2016-09-07" version="1">MNLEANTFDTFKVEPSLMTVFEQSHTWDELIQHFVDSYVMETDKKAVSAFYDRDYIAERLKGLETELSLECRITLNGEERWVRNVIIRGEIEDSEYAMIFLRDITEAKVESARHLQMAADNASMEQLIQSIVRLVDRFVVCDLENDRYESYNLNGQMIYKPLGFYHDFQMQVLERYKTLEAIDILIAPDNIRKKLKSENDIYKFEYCSLDEKTYKIASYIPLEWKNGKLEKVLLASMDVTQEKKAEIESRQALKEAYRSAENANRAKTEFLSNMSHVLLCLDWLYLIDAAEVDKKGRINLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K1A5</accession>
    <name>A0A174K1A5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA family ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">PhoH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybeZ</name>
        <name evidence="8" type="ORF">BWLFYP14_02664</name>
        <name evidence="4" type="ORF">ERS852478_00166</name>
        <name evidence="5" type="ORF">ERS852523_00323</name>
        <name evidence="7" type="ORF">GT712_00625</name>
        <name evidence="6" type="ORF">GT728_06160</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">2789STDY5834863</strain>
            <strain evidence="5 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 13">BIOML-A1</strain>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000003">
        <property type="protein sequence ID" value="CUP03628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703224.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000032_gene391"/>
    <dbReference type="EnsemblBacteria" id="CUN45437">
        <property type="protein sequence ID" value="CUN45437"/>
        <property type="gene ID" value="ERS852478_00166"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03628">
        <property type="protein sequence ID" value="CUP03628"/>
        <property type="gene ID" value="ERS852523_00323"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="3">
        <location>
            <begin position="112"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN45437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP03628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL32800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS87630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="336" mass="37523" checksum="DF653D1DACE69A9A" modified="2016-09-07" version="1">MAGNIIELHTEVPAELEANVFGQFDEHLKLIERTLNVTVISRDGILKILGNEQNAASAKKLIEELTVLAKRGNTITKQNVNYALSLAMEQRNEVLTEIDKDFICNTIQGRPIKPKTLGQKDYVEQIRKKMIVFGVGPAGTGKTYLAMAMAVTAFRNEEVSRIILTRPAIEAGEKLGFLPGDLQSKVDPYLRPLYDALYQIMGADSFAKNMERGLIEVAPLAYMRGRTLDNAFIILDEAQNTTPAQMKMFLTRIGFGSKVIITGDASQKDLPRDTTSGLDVAMKVLKKIDDIGFCQLTSKDVVRHPLVQQIVQAYDAYEKKQKPERPARRRNGVNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KDS7</accession>
    <name>A0A174KDS7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyacyl-[acyl-carrier-protein] dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fabZ</name>
        <name evidence="14" type="ORF">BWLFYP14_03089</name>
        <name evidence="10" type="ORF">ERS852478_01145</name>
        <name evidence="11" type="ORF">ERS852523_00466</name>
        <name evidence="13" type="ORF">GT712_03490</name>
        <name evidence="12" type="ORF">GT728_00730</name>
    </gene>
    <organism evidence="11 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">2789STDY5834863</strain>
            <strain evidence="11 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 19">BIOML-A1</strain>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP07450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704118.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2157"/>
    <dbReference type="EnsemblBacteria" id="CUN81766">
        <property type="protein sequence ID" value="CUN81766"/>
        <property type="gene ID" value="ERS852478_01145"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07450">
        <property type="protein sequence ID" value="CUP07450"/>
        <property type="gene ID" value="ERS852523_00466"/>
    </dbReference>
    <dbReference type="GeneID" id="66493981"/>
    <dbReference type="eggNOG" id="COG0764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010084">
        <property type="entry name" value="FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01750">
        <property type="entry name" value="fabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN81766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP07450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL31758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS88175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX66813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="143" mass="15359" checksum="1F748D5302ECE9CD" modified="2016-09-07" version="1">MKLTTKEIMEIIPHRHPFLLIDTIEELVPGVKATGKKCVTYNEPHFAGHFPQEPVMPGVLIVEALAQTGAVAILSKPENKGKIAYFASINNAKFKNKVVPGDTLTLEVEIIKEKGPMGVGKAKATNQDGKVAVIAELTFAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LWI5</accession>
    <name>A0A174LWI5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sigV_1</name>
        <name evidence="5" type="ORF">ERS852478_00926</name>
        <name evidence="6" type="ORF">ERS852523_01128</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
            <strain evidence="6 8">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000009">
        <property type="protein sequence ID" value="CUP28584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000054_gene1895"/>
    <dbReference type="EnsemblBacteria" id="CUN73332">
        <property type="protein sequence ID" value="CUN73332"/>
        <property type="gene ID" value="ERS852478_00926"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP28584">
        <property type="protein sequence ID" value="CUP28584"/>
        <property type="gene ID" value="ERS852523_01128"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="116"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN73332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP28584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="168" mass="19502" checksum="5E7203EED9BCEE1B" modified="2016-09-07" version="1">MITEKQYLEYLIKQYQNLIYSICLKSVGNPFDAEDLTQEVFLSAYKNLSRFDGNYEKAWLSKIAVRKCLDYLKAAGRRSIPTEDTYFSQIPDRQSSPEDEYMKTASNTHVEALCMQLKSPYKEVAYAHFCKELSVPEIAQQTGKNPKTIQTQLYRARAMLKKMLERGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MRN2</accession>
    <name>A0A174MRN2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02089</name>
        <name evidence="1" type="ORF">ERS852478_00490</name>
        <name evidence="2" type="ORF">ERS852523_01383</name>
        <name evidence="4" type="ORF">GT712_12560</name>
        <name evidence="3" type="ORF">GT728_11525</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000011">
        <property type="protein sequence ID" value="CUP36485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000026">
        <property type="protein sequence ID" value="MZL33810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000024">
        <property type="protein sequence ID" value="MZS89878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000038">
        <property type="protein sequence ID" value="VUX65600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005427475.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000030_gene3625"/>
    <dbReference type="EnsemblBacteria" id="CUN57102">
        <property type="protein sequence ID" value="CUN57102"/>
        <property type="gene ID" value="ERS852478_00490"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP36485">
        <property type="protein sequence ID" value="CUP36485"/>
        <property type="gene ID" value="ERS852523_01383"/>
    </dbReference>
    <dbReference type="GeneID" id="67480452"/>
    <dbReference type="eggNOG" id="ENOG5033A2R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN57102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP36485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="73" mass="8217" checksum="C85206F11AB04093" modified="2016-09-07" version="1">MAVERTYYTIDPEGKLTCMKCKVPLVKGKAKFMYLENGFPVEMPVCPKCGFVYVPEELALGKVLAVERALEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174P3V0</accession>
    <name>A0A174P3V0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ilvD_1</name>
        <name evidence="15 16" type="synonym">ilvD</name>
        <name evidence="16" type="ORF">ERS852478_03201</name>
        <name evidence="17" type="ORF">ERS852523_01940</name>
        <name evidence="19" type="ORF">GT712_14575</name>
        <name evidence="18" type="ORF">GT728_18240</name>
    </gene>
    <organism evidence="17 21">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 20 21" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 20">2789STDY5834863</strain>
            <strain evidence="17 21">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="18 22 23" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 23">BIOML-A1</strain>
            <strain evidence="19 22">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000018">
        <property type="protein sequence ID" value="CUP53727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000068">
        <property type="protein sequence ID" value="MZL35064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000032">
        <property type="protein sequence ID" value="MZS90261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380362.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000004_gene1928"/>
    <dbReference type="EnsemblBacteria" id="CUO56621">
        <property type="protein sequence ID" value="CUO56621"/>
        <property type="gene ID" value="ERS852478_03201"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP53727">
        <property type="protein sequence ID" value="CUP53727"/>
        <property type="gene ID" value="ERS852523_01940"/>
    </dbReference>
    <dbReference type="GeneID" id="66493906"/>
    <dbReference type="eggNOG" id="COG0129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
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        </location>
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        <location>
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        <ligand>
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            <position position="120"/>
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        <ligand>
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        <ligand>
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        </ligand>
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            <position position="442"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="121"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO56621.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUP53727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MZL35064.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZS90261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
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    </evidence>
    <sequence length="557" mass="58917" checksum="B2EFB2E1B7A2DD2C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QDR7</accession>
    <name>A0A174QDR7_9FIRM</name>
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        <submittedName>
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    <gene>
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        <name evidence="2" type="ORF">ERS852478_00879</name>
        <name evidence="3" type="ORF">ERS852523_02466</name>
        <name evidence="5" type="ORF">GT712_08085</name>
        <name evidence="4" type="ORF">GT728_01130</name>
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        <lineage>
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            <taxon>Clostridia</taxon>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
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            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 10">BIOML-A12</strain>
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    </reference>
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                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="ERS852478_00879"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="6">
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
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    </evidence>
    <sequence length="81" mass="8778" checksum="433ED270301CC6CE" modified="2016-09-07" version="1">MTYKTKGVCASHIEFEVDDNKKVHNVRFIGGCSGNTQGVASLVEGMDAEEVISRLKGIKCGFKNTSCPDQLSTALEEVLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QWA6</accession>
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        </submittedName>
    </protein>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
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                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000042">
        <property type="protein sequence ID" value="MZS90573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704367.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000094.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64236">
        <property type="protein sequence ID" value="CUO64236"/>
        <property type="gene ID" value="ERS852478_03434"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP77474">
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        <property type="gene ID" value="ERS852523_02762"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <location>
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            <end position="23"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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            <dbReference type="EMBL" id="CUO64236.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUP77474.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90573.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="69" mass="7717" checksum="1BA81125916E09B3" modified="2016-09-07" version="1">MKAHKYWSLGALAAMIGTFYTGYKNMKTAHKYFACSSLLCMIMAIYSGHKMISGKSRKKKNSVSKESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174S706</accession>
    <name>A0A174S706_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uma2 family endonuclease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein conserved in cyanobacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_02187</name>
        <name evidence="2" type="ORF">ERS852478_01946</name>
        <name evidence="3" type="ORF">ERS852523_03232</name>
        <name evidence="5" type="ORF">GT712_02610</name>
        <name evidence="4" type="ORF">GT728_10615</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000043">
        <property type="protein sequence ID" value="CUP90970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000023">
        <property type="protein sequence ID" value="MZL33638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS88005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703578.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13283">
        <property type="protein sequence ID" value="CUO13283"/>
        <property type="gene ID" value="ERS852478_01946"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP90970">
        <property type="protein sequence ID" value="CUP90970"/>
        <property type="gene ID" value="ERS852523_03232"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO13283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP90970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="171" mass="20402" checksum="E01F9737A89F4437" modified="2016-09-07" version="1">MDWNLKITDMAGATPEHSSVIVNFVAAVRYQLKNSTCYVYSDNVQYRFKDAEGNNKIVIPDASINCRTKSRRGNTFTDAPRFVMEVLSPSTEKYDRTEKMELYAQQEIEEYWIVDWRTKTIEIYELDYDENDIPKYYLWKTISEENKDELRLVHFPNIKITFEDLFDEIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174T1H8</accession>
    <name>A0A174T1H8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ppiB</name>
        <name evidence="11" type="ORF">BWLFYP14_02883</name>
        <name evidence="7" type="ORF">ERS852478_02836</name>
        <name evidence="8" type="ORF">ERS852523_03592</name>
        <name evidence="10" type="ORF">GT712_17610</name>
        <name evidence="9" type="ORF">GT728_14490</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000056">
        <property type="protein sequence ID" value="CUQ00659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000038">
        <property type="protein sequence ID" value="MZL34375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000052">
        <property type="protein sequence ID" value="MZS90825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000064">
        <property type="protein sequence ID" value="VUX66506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993454.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000066_gene3224"/>
    <dbReference type="EnsemblBacteria" id="CUO44575">
        <property type="protein sequence ID" value="CUO44575"/>
        <property type="gene ID" value="ERS852478_02836"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ00659">
        <property type="protein sequence ID" value="CUQ00659"/>
        <property type="gene ID" value="ERS852523_03592"/>
    </dbReference>
    <dbReference type="GeneID" id="66494773"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PTHR45625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO44575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUQ00659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL34375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS90825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX66506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="172" mass="18917" checksum="5970721105F12827" modified="2016-09-07" version="1">MANPIVTITMDNGDVMKAELYPEIAPNTVNNFISLVKKGFYDGLIFHRVINGFMIQGGCPDGTGMGGPGYSIKGEFTQNRFKNDLKHTAGVLSMARAMHPNSAGSQFFIMHKDAPHLDGAYAAFGKITEGMDVVNRIAEEDTDYSDRPLDEQKIKSMTVETFGVDYPEPEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174TVP0</accession>
    <name>A0A174TVP0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PadR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator YqjI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yqjI</name>
        <name evidence="2" type="ORF">ERS852478_03741</name>
        <name evidence="3" type="ORF">ERS852523_04015</name>
        <name evidence="5" type="ORF">GT712_18735</name>
        <name evidence="4" type="ORF">GT728_19105</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A1</strain>
            <strain evidence="5 8">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000046">
        <property type="protein sequence ID" value="CUO73504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000075">
        <property type="protein sequence ID" value="CUQ11480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000080">
        <property type="protein sequence ID" value="MZL35223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000063">
        <property type="protein sequence ID" value="MZS91018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379877.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000080.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000079_gene2734"/>
    <dbReference type="EnsemblBacteria" id="CUO73504">
        <property type="protein sequence ID" value="CUO73504"/>
        <property type="gene ID" value="ERS852478_03741"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ11480">
        <property type="protein sequence ID" value="CUQ11480"/>
        <property type="gene ID" value="ERS852523_04015"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO73504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ11480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL35223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS91018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="109" mass="12440" checksum="70F6E7DD371C423D" modified="2016-09-07" version="1">MAIEKSLVSGSMTMLILKLLSEKDMYGYEMIDTLRQKSQNVFELKAGTLYPLLHSLEDKGFLTVYEQEAAGKTRKYYSLTGQGRGFLEKKVEEWKEYSAAVTNVLVMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174U4S2</accession>
    <name>A0A174U4S2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01097</name>
        <name evidence="4" type="ORF">ERS852523_04206</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
            <strain evidence="4 6">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000091">
        <property type="protein sequence ID" value="CUQ16336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052610.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000045_gene2057"/>
    <dbReference type="EnsemblBacteria" id="CUN80013">
        <property type="protein sequence ID" value="CUN80013"/>
        <property type="gene ID" value="ERS852478_01097"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ16336">
        <property type="protein sequence ID" value="CUQ16336"/>
        <property type="gene ID" value="ERS852523_04206"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12837">
        <property type="entry name" value="Fer4_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN80013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUQ16336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="239" mass="26017" checksum="DBDF218F5CC7C54B" modified="2016-09-07" version="1">MIRKIIRIDKEKCNGCGACADACHEGAIDIINGKAELVREHFCDGLGDCLPECPTGAISFEEREAPEYDEAAVKEAQKKIFAKNQAITAHAGCPGSKSMQIQRSEIPKSEKPSSTTGQVSNLQNWPVQIKLAPVSAPYFNGAKLLIAADCTAYAYAGFHQDFIRNKVTLIGCPKLDQVDYSEKLTAIIQNNDIQSVTIVRMEVPCCGGLEMATRKALQNSGKFIPWQVITIGIDGNIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WRE0</accession>
    <name>A0A173WRE0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH-quinone oxidoreductase subunit 1</fullName>
            <ecNumber evidence="13">1.6.5.11</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="14">NADP-reducing hydrogenase subunit HndC</fullName>
            <ecNumber evidence="14">1.12.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nqo1_1</name>
        <name evidence="14" type="synonym">hndC_1</name>
        <name evidence="14" type="ORF">BWLFYP14_02550</name>
        <name evidence="13" type="ORF">ERS852478_00049</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="13"/>
    <dbReference type="EC" id="1.12.1.3" evidence="14"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199478.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN42149">
        <property type="protein sequence ID" value="CUN42149"/>
        <property type="gene ID" value="ERS852478_00049"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050583">
        <property type="term" value="F:hydrogen dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="565"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="595"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN42149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX66178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="623" mass="67994" checksum="8FF60327EC5431B9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WW24</accession>
    <name>A0A173WW24_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703089.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43126">
        <property type="protein sequence ID" value="CUN43126"/>
        <property type="gene ID" value="ERS852478_00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN43126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="128" mass="14606" checksum="34473BBB146ABE2D" modified="2016-09-07" version="1">MKKKIELVCWILFTVFSGIGFFINFMSKPPVNDTHTFTLYMIGAAVVSLLYPASMFVLGLRNRYLYDKLNELAEEKGETEVAKSAHTFRSSASGYTVPDMDILVSALTSDQKLTEEEKEYLLEYIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WWR8</accession>
    <name>A0A173WWR8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199497.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43366">
        <property type="protein sequence ID" value="CUN43366"/>
        <property type="gene ID" value="ERS852478_00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13751">
        <property type="entry name" value="DDE_Tnp_1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF772" evidence="2">
        <location>
            <begin position="53"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Tnp_DDE_dom" evidence="3">
        <location>
            <begin position="341"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN43366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="493" mass="57822" checksum="2464DD6E0D18343B" modified="2016-09-07" version="1">MMTKNADKKREQMMMFSMDDMVPQNHMLRLIDKAINWNFIYDLVEEKYCSDNGRPSMDSVMLIKIPFIQYLYGIKSMRQTMKEIEVNVAYRWFLGLDMLDPIPHFSTFGKNYTRRFKDTDLFEQIFSKILEDCMKYNLVNTGQIFVDATHVKACANSKKMRKRVAHEQALWYEEELNKEIEEDRLAHGKKPLKKKDDNQPPASGGTGNDKDSISEELPENVKTQKCSISDPESGWFRKGEHKHVFAYAVETACDKHGWILGYTVHPGNEHDSRTFKALYDKISKLNPQMVVADAGYKTPAIAHQLLEDGIQPLFPYTRPKTKEDFFGKHEFAYDEYYDCYICPGAHILTYSTTNRSGYKEYKSCGEHCAECQYLSKCTESKDHIKLITRHVWEEYMEVAEDIRHTIGNRQIYQLRKETIERIFGTAKEQHGFRYTQYVGKARMEMKAGLTFACMNLKKLAKILEKRGWNTARFLLILKKIKRKEVLKEKWCWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WZ53</accession>
    <name>A0A173WZ53_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonuclease G</fullName>
            <ecNumber evidence="7">3.1.26.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rng</name>
        <name evidence="7" type="ORF">ERS852478_00096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.26.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199502.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43595">
        <property type="protein sequence ID" value="CUN43595"/>
        <property type="gene ID" value="ERS852478_00096"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="45"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN43595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="404" mass="46223" checksum="0E1C75A61DFFCFF3" modified="2016-09-07" version="1">MKKLSKLIITQMNIRQISCYVCAYEEDGKVMELRFEPVGEKSSLGNIYVGQIENIAANIGAAFVQISAGEKCYLQLSDAPNAIYASVKKGDRPLKAGDEILVQISREAMKGKLPAVTTNLNFTGKYLVLTTGDKKFGLSSKLSNDDRSRISKWMEAEVNRPDKEFGIIVRTNAADASKEEILKELEYLKGLYHKAAVDGRSRTCFSCVYRTEPFYISAVRDANSRNLEEIITDIPEISRQISDYLNSNSPEEKEKLRFYDDKLLPLYKLYRLETVLEEIQHEKVWLNSGGFLVIQQTEAFVSIDVNSGKFTGKKKMQETYRKINLEAAKEIVRQLRLRNLSGIILIDFINMENQDHQDELFHVLQKYLRKDPVKAKAVDITPLHILELTRKKVRKPVIEEIREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X5K9</accession>
    <name>A0A173X5K9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diaminopropionate ammonia-lyase</fullName>
            <ecNumber evidence="4">4.3.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dpaL</name>
        <name evidence="6" type="ORF">BWLFYP14_02683</name>
        <name evidence="4" type="ORF">ERS852478_00187</name>
        <name evidence="5" type="ORF">GT712_00525</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.3.1.15" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381424.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45905">
        <property type="protein sequence ID" value="CUN45905"/>
        <property type="gene ID" value="ERS852478_00187"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008838">
        <property type="term" value="F:diaminopropionate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010081">
        <property type="entry name" value="DiNH2opropionate_NH3_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019871">
        <property type="entry name" value="DiNH2propionate_NH3-lyase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03528">
        <property type="entry name" value="2_3_DAP_am_ly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01747">
        <property type="entry name" value="diampropi_NH3ly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="40"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN45905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS87612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="409" mass="44823" checksum="350F0971F37EF373" modified="2016-09-07" version="1">MTEGLKWTVNEVPKSDDKHLELMSEENVKKANEFHRSFPQYSVTPLQNLSSLAKYLGVKNIFCKDESYRFGLNAFKVLGGSYAMGRYIAKELGRDISELPYNVLSSDKLREEFGQATFFTATDGNHGRGVAWAANRLGQKAVVRMPKGTTKTRFDNIAKEGATVTIEEVNYDDCVRMAAAEAAKTEHGIIVQDTAWDGYEEIPSWIMQGYGTLVLEADQQLKEMGVERPTHVFVQAGVGSLAGAVVGYFAHKYKDNPPVMAVCEASAADCLYRSAVAKTGNLVNVTGDLQTIMAGLACGEGNMIGWDILKNHVDVFASCPDWMSAKATRIYANPLGDDPHVVSGESGSVPLGFCFTALHDEDAKDLKEALKLDENSVVLVISTEGDTDPVRYREIVWDGLYGTNESLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XCY8</accession>
    <name>A0A173XCY8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hisJ_1</name>
        <name evidence="4" type="ORF">ERS852478_00273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199537.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49513">
        <property type="protein sequence ID" value="CUN49513"/>
        <property type="gene ID" value="ERS852478_00273"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015352" evidence="2">
        <location>
            <begin position="24"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="3">
        <location>
            <begin position="37"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN49513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="271" mass="30442" checksum="846366ACABB170FF" modified="2016-09-07" version="1">MKGKRVIAGILLVGIIAASLAGCKNTNITKKEREKPVITLGSDSYPPYNYLNEDGIPTGIDVELATEAFRRMGYQVDVVQINWEEKKELVESGEIDCIMGCFSMEGRLDDYRWAGPYIASRQVVAVNESSDIYKLSDLEGKNLAVQSTTKPEGIFLNRTDERIPKLGNLISLGHRELIYTFLGKGYVDAVAAHEESIVQYMKDYDASFRILEEPLMVVGIGVAFAKEDDRGICEQMDQTLEEMRQDGTSLKIIKKYLDDPQKYLEVDDLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XNE6</accession>
    <name>A0A173XNE6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_00365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52397">
        <property type="protein sequence ID" value="CUN52397"/>
        <property type="gene ID" value="ERS852478_00365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015548" evidence="3">
        <location>
            <begin position="29"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="753"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN52397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="846" mass="91759" checksum="91186765A8A843DF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XS92</accession>
    <name>A0A173XS92_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phage shock protein C</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">PspC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pspC</name>
        <name evidence="12" type="ORF">BWLFYP14_02059</name>
        <name evidence="8" type="ORF">ERS852478_00445</name>
        <name evidence="9" type="ORF">ERS852523_02728</name>
        <name evidence="11" type="ORF">GT712_06560</name>
        <name evidence="10" type="ORF">GT728_14845</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000031">
        <property type="protein sequence ID" value="CUP76352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000040">
        <property type="protein sequence ID" value="MZL34442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000009">
        <property type="protein sequence ID" value="MZS88741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706626.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000051_gene804"/>
    <dbReference type="EnsemblBacteria" id="CUN54771">
        <property type="protein sequence ID" value="CUN54771"/>
        <property type="gene ID" value="ERS852478_00445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP76352">
        <property type="protein sequence ID" value="CUP76352"/>
        <property type="gene ID" value="ERS852523_02728"/>
    </dbReference>
    <dbReference type="GeneID" id="66496076"/>
    <dbReference type="eggNOG" id="COG1983">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN54771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP76352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL34442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS88741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX65468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="61" mass="6682" checksum="295614C6F126E930" modified="2016-09-07" version="1">MGDKRLYKSSENSMLCGVCGGIAEYFDIDPTLVRLAWVILTCFGGAGIWAYIIAAIIIPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XV54</accession>
    <name>A0A173XV54_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized oxidoreductase ycjS</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ycjS</name>
        <name evidence="3" type="ORF">ERS852478_00447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199627.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54816">
        <property type="protein sequence ID" value="CUN54816"/>
        <property type="gene ID" value="ERS852478_00447"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="134"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN54816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="322" mass="35838" checksum="31539B7C756E9449" modified="2016-09-07" version="1">MKLGILGAGGIASTMAKTVAGMKDVEAYAVAARDLERARVFAQKYEVKKAYGSYEEMLADDEVGLVYIATPHSHHYLHAKMCLEAGKHVLCEKAFTVNAEQAQKLFDLAKEKKLLITEAIWTRYMPSRKMINDIIESGVIGEVTAVTANLSYTVSHVERIRKPELAGGALLDVGVYPINFASMVLGDKVKDVKATAIFQNGVDILDSIAMVFEGDRMATLQCGAREISDRMGSIFGTRGYMQVQNINNPEKITVFDTEHKEVASYVVPEQISGYEYEVESCKKAIHEGKPECPEMPHAETIRIMKIMDDIRKSWNYEIPCIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XZ19</accession>
    <name>A0A173XZ19_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine dehydrogenase accessory protein XdhC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199667.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56909">
        <property type="protein sequence ID" value="CUN56909"/>
        <property type="gene ID" value="ERS852478_00484"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="15"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="186"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN56909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="341" mass="37468" checksum="DD848F15B4B78317" modified="2016-09-07" version="1">MRTLFQTIKQQFLEGNDLVLVSVTASSGSTPRGAGSRMLVGKNGRISGTIGGGAVEYRAECMALDILEKKESCQHEFRLNHKDVENIGMICGGDVTAFFQYLNHNDPIIMEITETAEKFYEKRKDFWLICDLLTTSGVSLYSPACGLIGTANVPSSVLSSLSAKPHRYHSEDYDLFSEQIGTSGTVYVFGGGHVSQKLVPILASVDFRCVVLDDRPEFTDPALFPGAVETILCDFNHLKQYVSITAADYCCVMTRGHSYDTIVQAQLLATPACYIGVIGSRTKKAAVFRRLIEEYNINEQDLNRIISPIGLEIKAETPAEIAISITGQMIQVRADRKATSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y120</accession>
    <name>A0A173Y120_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylacetate-coenzyme A ligase</fullName>
            <ecNumber evidence="2">6.2.1.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">paaK</name>
        <name evidence="2" type="ORF">ERS852478_00494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.30" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57250">
        <property type="protein sequence ID" value="CUN57250"/>
        <property type="gene ID" value="ERS852478_00494"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047475">
        <property type="term" value="F:phenylacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="93"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN57250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="398" mass="44600" checksum="5E2E2A90012E8352" modified="2016-09-07" version="1">MKRSNIDAMICKQERITDITREAINKIQLDKLNAVLKREKEREGFYRNLPERLESLADLKALPFTTESDLAQKGGRMLLCSQGEIQRIISEQTSGTTGAGKRVFYTEGDCEHTIELFMAGLGEFIYPGSRTMVAMPFSGPFGLGELIAEAIRRIGAHPLLTGNSKTYGELKTILEEEQPDTYVGMPTALLSMLRMCGKGSIKRALVSGDACPETVMKEIEKILGTPLWPHYGSREMGLGGAICCQAHEGMHMRENHCITEIIDKEGNVLPDGQWGELVITTIGMEAQPLIRYRTGDHTRIIPGKCICGSEVRRLDFVRRIDQSKSMREMDELLFQFPELVDYCVRSVGGKKEITALFTSDNGEELIRNVCAEKNIISLDCRKAEWSDRALYPAKRIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y183</accession>
    <name>A0A173Y183_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199670.1">
        <property type="nucleotide sequence ID" value="NZ_JAAINB010000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57006">
        <property type="protein sequence ID" value="CUN57006"/>
        <property type="gene ID" value="ERS852478_00487"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503094H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN57006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="86" mass="9575" checksum="5B17955893EF8F77" modified="2016-09-07" version="1">MDKIFEITAKEVTVQVKDERTGVVYSRTLPIDYYENANVLKLSGENLDGSSSSIVFYSARGIERLKDLTGKGADHDPCGVHKPEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y4W0</accession>
    <name>A0A173Y4W0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58590">
        <property type="protein sequence ID" value="CUN58590"/>
        <property type="gene ID" value="ERS852478_00537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN58590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="111" mass="13557" checksum="F24984754A919699" modified="2016-09-07" version="1">MRDFSFLYPQYYSSEKEWNDHRNLIKISIFLFGKNATTPDIKDDLVYLAESMIEYKPEVNHKLQFVNDPKVEKYYLHRDSHRTEFVNYMFSLCEQNEDLNFEKDAFNHLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y8R8</accession>
    <name>A0A173Y8R8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5071 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_03267</name>
        <name evidence="2" type="ORF">ERS852478_00589</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX66990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578529.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60249">
        <property type="protein sequence ID" value="CUN60249"/>
        <property type="gene ID" value="ERS852478_00589"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038692">
        <property type="entry name" value="Cthe_2751_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031837">
        <property type="entry name" value="DUF5071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16804">
        <property type="entry name" value="DUF5071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5071" evidence="1">
        <location>
            <begin position="52"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN60249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="150" mass="18092" checksum="6CE71BDDC7E39528" modified="2016-09-07" version="1">MGTDIDTIFKMLSWNSSEKEQLRGIDEAKKIEYLSVLFQPIEDKSVWENCAKVISSKSDNELKKYMNNMFEWIKDMNWPGAFDIYARIKRMNVDCIMENYIYAIKIALKYQDINWLDYLSGLIENPEVYKLLPEEYQKLMTKYYNDFWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YK49</accession>
    <name>A0A173YK49_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacillibactin transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">btr_1</name>
        <name evidence="3" type="ORF">ERS852478_00673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199753.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64119">
        <property type="protein sequence ID" value="CUN64119"/>
        <property type="gene ID" value="ERS852478_00673"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="187"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN64119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="301" mass="34184" checksum="70E34D5CF4B264D0" modified="2016-09-07" version="1">MPNVKYTDSATFRCLENLKEGSLDISLIHTGKEHCPPGHICSMPRDEFIIHFVLDGTGFYSAGGQTRSLTPGQMFVIYPNEPVTYGADETHPWTYAWIGFRGIRAHSLVRECGFSKNQLVLPAPDQKIILKHIDYMLDHKQLSKANDLRRQAYLILLLAELADFHEKQSAQSRKNAKYAYNTSVYVELAIEYIKDMYQKGIGISDIADNIGISRAYLNSSFQKELGMSAQTFLIDYKMHKAASLLVSTSLSVKEIANNVGYEDQLVFSKAFKKKFGMSPKNYKTHKEMMDKFNEKQVDDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YLA7</accession>
    <name>A0A173YLA7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Branched-chain amino acid ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">High-affinity branched-chain amino acid transport system permease protein LivH</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">LIV-I protein H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">livH</name>
        <name evidence="11" type="ORF">BWLFYP14_01813</name>
        <name evidence="7" type="ORF">ERS852478_00695</name>
        <name evidence="8" type="ORF">ERS852523_00649</name>
        <name evidence="10" type="ORF">GT712_03215</name>
        <name evidence="9" type="ORF">GT728_03710</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP13060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706530.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000015_gene3705"/>
    <dbReference type="EnsemblBacteria" id="CUN64872">
        <property type="protein sequence ID" value="CUN64872"/>
        <property type="gene ID" value="ERS852478_00695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13060">
        <property type="protein sequence ID" value="CUP13060"/>
        <property type="gene ID" value="ERS852523_00649"/>
    </dbReference>
    <dbReference type="GeneID" id="66493472"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN64872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP13060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL32322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS88122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX65052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="295" mass="30167" checksum="9EDA591658A37716" modified="2016-09-07" version="1">MSSFISYLISGISLGSVYAIIALGYTMVYGIAKMLNFAHGDVIMVGSYVVYVAVSGMGLNPILAILLSIIICTLMGVVIEGVAYRPLRNAASPLAVLITAIGVSYLLQNVALLIWGADTKSFSNVISLPSLKLAGGSIVITGVTIVTIIGGILIMAGLMLFISKTKTGQAMLAVSEDKGAAQLMGINVNKTISITFAIGSGLAAIAGVLLCSAYPSLTPYTGAMPGIKAFVAAVFGGIGSIPGAFIGGVVLGILEIFGKAYISSQMADAIVFGVLIVVLVVKPTGILGKNIQEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YN82</accession>
    <name>A0A173YN82_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00720</name>
        <name evidence="2" type="ORF">ERS852523_00624</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP12382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055149523.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65621">
        <property type="protein sequence ID" value="CUN65621"/>
        <property type="gene ID" value="ERS852478_00720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12382">
        <property type="protein sequence ID" value="CUP12382"/>
        <property type="gene ID" value="ERS852523_00624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN65621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP12382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="64" mass="7107" checksum="24C130D4A9161080" modified="2016-09-07" version="1">MGKIEFANCQDVRNQKRIQELDCPHCHEPGGIEAFVKDGILAEDGVCDNCGYILPEGTELEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YXZ8</accession>
    <name>A0A173YXZ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="5">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">hisC</name>
        <name evidence="9" type="ORF">BWLFYP14_01749</name>
        <name evidence="7" type="ORF">ERS852478_00771</name>
        <name evidence="8" type="ORF">ERS852523_00571</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
            <strain evidence="8 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP10886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055149489.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000036_gene2428"/>
    <dbReference type="EnsemblBacteria" id="CUN67628">
        <property type="protein sequence ID" value="CUN67628"/>
        <property type="gene ID" value="ERS852478_00771"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP10886">
        <property type="protein sequence ID" value="CUP10886"/>
        <property type="gene ID" value="ERS852523_00571"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 5 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="6">
        <location>
            <begin position="24"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN67628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP10886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX64924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="351" mass="40463" checksum="F0658968FBC3FABC" modified="2016-09-07" version="1">MSRWEENIRKVIPYTPGEQPNQPDMIKLNTNENPYPPAPGVEKALREMDTDTMRLYPDPTAGELVHAIAKNYGLKDEQVFVGVGSDDVLAMSFLTFFNSQKPVLFPDITYSFYDVWADLFRIPYERPALDENFHIRTEDYFRENGGIVFPNPNAPTGVEMPLEEVEDIIRHNPDVIVIVDEAYVDFGSQSALPLIEKYDNLLVVQTFSKSRSMAGMRIGFACGNEKLIRFLNDVKYSFNSYTMDRTAIAAGVAAVEDKAYFDETCNKIIETREWTKKELKALGFSFQDSMSNFIFATHKTCPAKELFEALRGQHIYVRYFQKDRIDNFLRITVGTKEEMQKFIDFLKDYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YZB6</accession>
    <name>A0A173YZB6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_01724</name>
        <name evidence="1" type="ORF">ERS852478_00797</name>
        <name evidence="3" type="ORF">GT712_02785</name>
        <name evidence="2" type="ORF">GT728_12540</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">BIOML-A1</strain>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000030">
        <property type="protein sequence ID" value="MZL34006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706404.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68566">
        <property type="protein sequence ID" value="CUN68566"/>
        <property type="gene ID" value="ERS852478_00797"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032TFN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN68566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL34006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS88036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="81" mass="9201" checksum="9964A7B1C89C5956" modified="2016-09-07" version="1">MVNQSVIDSSVNLEQLKDIEDLIPNIDKAISEKVETFLDKSGDQPYAHMNEGYVVVVEMTGEMDATDAISDYLRKRTELMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z6H6</accession>
    <name>A0A173Z6H6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenosylhomocysteine nucleosidase</fullName>
            <ecNumber evidence="2">3.2.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mtnN</name>
        <name evidence="10" type="ORF">BWLFYP14_01260</name>
        <name evidence="7" type="ORF">ERS852478_00878</name>
        <name evidence="9" type="ORF">GT712_08080</name>
        <name evidence="8" type="ORF">GT728_01125</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">BIOML-A1</strain>
            <strain evidence="9 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.9" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS89027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706966.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71921">
        <property type="protein sequence ID" value="CUN71921"/>
        <property type="gene ID" value="ERS852478_00878"/>
    </dbReference>
    <dbReference type="GeneID" id="66493004"/>
    <dbReference type="eggNOG" id="COG0775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008782">
        <property type="term" value="F:adenosylhomocysteine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008930">
        <property type="term" value="F:methylthioadenosine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010049">
        <property type="entry name" value="MTA_SAH_Nsdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01704">
        <property type="entry name" value="MTA/SAH-Nsdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="6">
        <location>
            <begin position="4"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN71921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL31833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX64153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="232" mass="25182" checksum="37A670CF56FC8EDB" modified="2016-09-07" version="1">MKCIGIIGAMEQEVAKIKEKMQDVTITSRARMDFYEGTLEGKKVVVVRSGIGKVNAGMCTQILADVFGVEAVINTGIAGSLNNDVNIGDIVLSTDVLHHDMDAIGFGYKKGQIPQMDEFSFPADEKLRKLAAKVCKEVNPEISVFEGRICSGDQFISDKSVKDAIISEFGGFAVEMEGAAIGQAAYLNHIPFLVVRAISDKADGSAHMDYAEFEMAAIEHSVKLTVRMIQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZDF2</accession>
    <name>A0A173ZDF2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199845.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73218">
        <property type="protein sequence ID" value="CUN73218"/>
        <property type="gene ID" value="ERS852478_00922"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN73218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="65" mass="7573" checksum="3AD5EA2962BFB02A" modified="2016-09-07" version="1">MSEICKNNCQNPYNICYDNYLNTNACTECTGLICTPAKDNDEWESYRKIFDFIPEPPESNIPPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZFS0</accession>
    <name>A0A173ZFS0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methylphosphotriester-DNA--protein-cysteine S-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">adaA_1</name>
        <name evidence="5" type="ORF">ERS852478_00946</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380938.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73975">
        <property type="protein sequence ID" value="CUN73975"/>
        <property type="gene ID" value="ERS852478_00946"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="195"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN73975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="295" mass="34130" checksum="2139F070E3B01B87" modified="2016-09-07" version="1">MPVTPTIEVDDTLKERSSHGSFELPIETYTDNCEIFHSLYNHWHDEMELIYIESGSGLVRLNKEILRVKAGDLIIVNRGVLHGIKTDLKNILYFRSIVFDLNFLSGPAGDLCQERVISLLMDNQAEFTHIISRSDDNYGNICLLFDRIHSCHKEKKPYYFVKLKALFFSFFYEMLMGNYITPADKEENKSLASIKKILDYINLNYSQSLTAAELTALSNYSEYYFMKLFKQYTGKTLIAYINDLRIEKAKPLLLHSDSSVTEIALEVGFNNTSYFIKKFQQATGMSPHKFRRNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZGP2</accession>
    <name>A0A173ZGP2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-N-arabinofuranosidase</fullName>
            <ecNumber evidence="5">3.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">abfA_2</name>
        <name evidence="5" type="ORF">ERS852478_00995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199879.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75562">
        <property type="protein sequence ID" value="CUN75562"/>
        <property type="gene ID" value="ERS852478_00995"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="4">
        <location>
            <begin position="303"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN75562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="500" mass="57436" checksum="7DFBD0390E120036" modified="2016-09-07" version="1">MTKLVINPSKKQSKINKEIYGHFSEHLGRCIYEGIYVGEDSQIPNKNGMRTDVVEALKHIRIPVLRWPGGCFADEYHWKDGIGPKETRKKMINTHWGGVVEDNSFGTHEFFELCEQLGCEAYVNGNLGSGTVQEMSEWVEYITFEGVSPMADLRKKNGHEKPWKLDFFGVGNENWGCGGNMNPDFYANEYRRYQTYVRNYHPDHPIHKVCCGANVDDYEWTSEVLKTTHNHCLKELHGNMDGLSLHYYVHPEGWEIKGSATDFDDKVWYKSLNKALFMETLIERHGHIMDEYDPEKKIGMIVDEWGAWYTVEPGTNPGFLYQQNTMRDALIAGITLNIFNKHSDRVKMANLAQIVNVLQSVILTDGADMILTPTYHVFDMYKYHQDAMLVDSSIETETIGVEDEWQVPNLTESVSVAEDGAVHITLTNLSLDKDYEIRTILTDYQVNEVKGEIVHGEMHEMNTFETPDQVRVKEFNEVEKTAEGIKFTIPKCSVLHLEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZN34</accession>
    <name>A0A173ZN34_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Colanic acid biosynthesis glycosyltransferase WcaL</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">DUF3492 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01037</name>
        <name evidence="4" type="ORF">GT712_17230</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000049">
        <property type="protein sequence ID" value="MZS90752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199904.1">
        <property type="nucleotide sequence ID" value="NZ_JADPFJ010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76856">
        <property type="protein sequence ID" value="CUN76856"/>
        <property type="gene ID" value="ERS852478_01037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022622">
        <property type="entry name" value="DUF3492"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11997">
        <property type="entry name" value="DUF3492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3492" evidence="2">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="292"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN76856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="480" mass="55797" checksum="10DD006983951D3B" modified="2016-09-07" version="1">MRICLVLEGCYPYVHGGVSTWMHQYITVMKEHEFVLWVIGAHACDRGKFVYELPDNVVEVHEVFLDDALKLKEHGNQKGQLHRINRFSEEETKSLRELMECSHPDWEVLFHLYHDRKMNPMSFLKSEQFLNILTESCLEKYPYIAFADAFHTMRSMLLPVLYLLGSEVPLADTYHAISTGYGGLLACLGGYVYRRPVLLTEHGIYTREREEEIIRAKWVIPSFKKQWISFFYMLSEAIYKRAFRVTSLFTNAMLTQIQIGCDAEKCRVIENGINYDRLSQIPLKEEDGWVDIGAVVRLAPIKDIKTMIYAFYELSSRMENVRLHILGGVDDEEYADECYALVKQLDIKNLVFTGRVDIVQYMRKLDFTILTSISEGQPLSVLESFAARRPCVTTDVGCCRELLNGKEGDDFGCAGYCVPPMYRDGLAAAMEKMCESRRRRIRMGKSGQARTKAYYRHERMISEYRKLYREVEEAYGRDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZSU8</accession>
    <name>A0A173ZSU8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA 5-hydroxyuridine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ho5U methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trmR</name>
        <name evidence="9" type="ORF">BWLFYP14_00358</name>
        <name evidence="5" type="ORF">ERS852478_01078</name>
        <name evidence="6" type="ORF">ERS852523_02693</name>
        <name evidence="8" type="ORF">GT712_13555</name>
        <name evidence="7" type="ORF">GT728_14225</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-hydroxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:60524"/>
            <dbReference type="Rhea" id="RHEA-COMP:13381"/>
            <dbReference type="Rhea" id="RHEA-COMP:15591"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:136877"/>
            <dbReference type="ChEBI" id="CHEBI:143860"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000030">
        <property type="protein sequence ID" value="CUP75404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000037">
        <property type="protein sequence ID" value="MZL34323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000028">
        <property type="protein sequence ID" value="MZS90069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707426.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000035_gene3830"/>
    <dbReference type="EnsemblBacteria" id="CUN79351">
        <property type="protein sequence ID" value="CUN79351"/>
        <property type="gene ID" value="ERS852478_01078"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP75404">
        <property type="protein sequence ID" value="CUP75404"/>
        <property type="gene ID" value="ERS852523_02693"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016300">
        <property type="term" value="F:tRNA (uracil) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02217">
        <property type="entry name" value="TrmR_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043675">
        <property type="entry name" value="TrmR_methyltr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN79351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP75404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL34323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS90069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX67513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="214" mass="24911" checksum="67A89E5B5AAFF255" modified="2016-09-07" version="1">MIVDERMRTYINSLDMGNTPFLEELEQYAIRERVPIIRREMQSFIKMFLAVNRPKRILEVGTAIGFSTLLMCEYGPEDLEIVTIENYEKRIPIAKENFRRAGREAQITLLEGDAGQILKELEDSFDMIFMDAAKGQYINWLPDVMRLMKNGGVLISDNVLQEGDIIESHYLVERRNRTIYKRMREYLYELKHNPSLITSIIPLGDGVTVSVKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A207</accession>
    <name>A0A174A207_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative HTH-type transcriptional regulator YvdT</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Uncharacterized HTH-type transcriptional regulator yvdT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yvdT</name>
        <name evidence="4" type="ORF">BWLFYP14_03098</name>
        <name evidence="3" type="ORF">ERS852478_01136</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199933.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81438">
        <property type="protein sequence ID" value="CUN81438"/>
        <property type="gene ID" value="ERS852478_01136"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN81438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="219" mass="25385" checksum="ED632258743D975C" modified="2016-09-07" version="1">MGKLELNKKKKKDALFNTAFELFTTKGLTKTTISDIVDQAGVAKGTFYLYFKDKYDIRNKLVSHKTGELFFWAHKAVQNAHISEFDRQVHFIIDYILTELNKDRTLLLFISKNLAWGVFKGAFEEKMPDDEYNFYQSYLDMLAQSGLHYKNPELMLFTIIELVGSTCYSCILYQQPVSLAEYRPYLHRTISGIMETFSQDHTTCEILSSDTKTHVDHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AGM8</accession>
    <name>A0A174AGM8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_01263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199993.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87069">
        <property type="protein sequence ID" value="CUN87069"/>
        <property type="gene ID" value="ERS852478_01263"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041045">
        <property type="entry name" value="LPD25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18840">
        <property type="entry name" value="LPD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="1764"/>
            <end position="2035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1882"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN87069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="2302" mass="262026" checksum="4B78B86CC5766E37" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ALZ8</accession>
    <name>A0A174ALZ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Melibiose operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">melR_2</name>
        <name evidence="5" type="ORF">ERS852478_01331</name>
        <name evidence="6" type="ORF">GT728_08080</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000015">
        <property type="protein sequence ID" value="MZL33158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057250.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89437">
        <property type="protein sequence ID" value="CUN89437"/>
        <property type="gene ID" value="ERS852478_01331"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="207"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN89437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL33158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="311" mass="36506" checksum="F7150375FEAA3189" modified="2016-09-07" version="1">MQNQQPSTLKEIRVHGTQDFPCAFYQTGTRIKGNMVKHHWHEEVELLYFSGGEFCLEVNMERFNISEECFYFINPGELHSISVEKNGGCVENAVVFHMDMLSSAYALDQIQTNLIQPVQNGSIQFPRCLRKNEPAFEPVRKSYEEIRNVFGGDSFRENYYDGEAVTDDITRQLFIKSALLRILAVLSANNLFEVTEKNHDHRIETIKTTLTYIQENYKEKIYIRDLAGLIGMNEQYFCRFFKKVIGRSPMEYVNEYRIKRAIHYLKESDLTVTEICLECGYNNLGNFLREFRKYTSTTPLQYRRHSLKETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ANM9</accession>
    <name>A0A174ANM9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cysE</name>
        <name evidence="10" type="ORF">ERS852478_01350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200027.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90057">
        <property type="protein sequence ID" value="CUN90057"/>
        <property type="gene ID" value="ERS852478_01350"/>
    </dbReference>
    <dbReference type="GeneID" id="66494894"/>
    <dbReference type="eggNOG" id="COG1045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010493">
        <property type="entry name" value="Ser_AcTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06426">
        <property type="entry name" value="SATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SATase_N" evidence="9">
        <location>
            <begin position="93"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN90057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="308" mass="34866" checksum="5E57263BEFB5F9DB" modified="2016-09-07" version="1">MTEKKKIILEAVEKLTDTYRKEELFLGKDRERLPNKKEIINFIKDMRSIIFPGYFSVDSSASVFPEHYVAYRLNDLYDCLQEQIEIAFLYQGEEEQKAKEHAERITERFFANVPEIQRMLLTDLQAGFDGDPAAKSKEEIIFSYPGFYAIYVYRLAHVLYLENVPFIPRIMSEYAHGYTGIDINPGATIGEYFFIDHGTGVVIGETTEIGRNVKLYQGVTLGALSTRQGQLLANVKRHPTIRDNVTIYSNSSVLGGETVIGENTIIGGNTFITASIPANTKVSAKSPELVIKKPKSEVEATNVWDWEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ANR2</accession>
    <name>A0A174ANR2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Branched-chain-amino-acid transaminase</fullName>
            <ecNumber evidence="9">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ilvE</name>
        <name evidence="18" type="ORF">BWLFYP14_01663</name>
        <name evidence="14" type="ORF">ERS852478_01323</name>
        <name evidence="15" type="ORF">ERS852523_00915</name>
        <name evidence="17" type="ORF">GT712_09520</name>
        <name evidence="16" type="ORF">GT728_08115</name>
    </gene>
    <organism evidence="14 19">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 19 20" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 19">2789STDY5834863</strain>
            <strain evidence="15 20">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="16 22 23" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 23">BIOML-A1</strain>
            <strain evidence="17 22">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="18 21" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000007">
        <property type="protein sequence ID" value="CUP21511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000015">
        <property type="protein sequence ID" value="MZL33165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705724.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000047_gene1250"/>
    <dbReference type="EnsemblBacteria" id="CUN89128">
        <property type="protein sequence ID" value="CUN89128"/>
        <property type="gene ID" value="ERS852478_01323"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21511">
        <property type="protein sequence ID" value="CUP21511"/>
        <property type="gene ID" value="ERS852523_00915"/>
    </dbReference>
    <dbReference type="GeneID" id="66494919"/>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="PTHR42825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN89128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUP21511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZL33165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MZS89302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VUX64807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="341" mass="37701" checksum="0055E6C1B36F5FEC" modified="2016-09-07" version="1">MEKKNIDWSSLGFGYVQTDYRYVSKFKDGAWDAGELTTDPNVTLNECAGVFQYAQTVFEGMKAYTTEDGHIVTFRPDLNAERMANSAKRLEMPVFPEDRFVDAIVQTVKANAAYVPPYGSGATLYVRPYMMGTNPVIGVKPADEYMFRVFTTPVGPYFKGGAKPITIRVSDFDRAAPHGTGHIKAGLNYAMSLHAIVDAHKNGFDENMYLDAATRTKVEETGGANFIFVTKDGKVVTPKSNSILPSITRRSLIYVAKEYLGLEAEEREIYFDEVKDFAECGLCGTAAVISPVGKIVDHGKEICFPSGMEKMGPVIQKLYDTLTGIQMGRIQAPEGWLKVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AP77</accession>
    <name>A0A174AP77_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">sn-glycerol-3-phosphate transport system permease protein ugpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ugpA_4</name>
        <name evidence="7" type="ORF">ERS852478_01357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058735.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90257">
        <property type="protein sequence ID" value="CUN90257"/>
        <property type="gene ID" value="ERS852478_01357"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="121"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN90257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="350" mass="38354" checksum="64520DA28AB41642" modified="2016-09-07" version="1">MNTNSASKKAISMVCLIAGIILLAAALIQDISGSGAGWRGPALIIGAIGILLGMYLFPTLKHHRSIVNFIFVFPLLFTFVVTVIIPLCLGVFYSFTDWNGIKMTGFIGFANYKAMFSEPSFLWSLIITILFVVLNMVLVNVVAFMLALLCTSKIKGLSFFRASYFLPNLIGGIVLGYVWQFVFNNVLIKMTNNISLLSKTNTAMMAIIVVYIWQYAGYIMLIYVTGLTQVPKDVLEASQIDGANAVTTLFKIKIPMIAATITICTFLTLTSAFKQFDVNMALTNGTGSVASFFGNYLTNGTQMLALNIYNTAISKNNYALGQAKAILFFIILAAVSIIQVRISNKKEVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B143</accession>
    <name>A0A174B143_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_S78_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01435</name>
        <name evidence="3" type="ORF">ERS852523_01016</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP24928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055149986.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93949">
        <property type="protein sequence ID" value="CUN93949"/>
        <property type="gene ID" value="ERS852478_01435"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP24928">
        <property type="protein sequence ID" value="CUP24928"/>
        <property type="gene ID" value="ERS852523_01016"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027924">
        <property type="entry name" value="XkdF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14550">
        <property type="entry name" value="Peptidase_S78_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S78_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN93949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP24928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="158" mass="18124" checksum="B49EC635B764C8BF" modified="2016-09-07" version="1">MKSFNEIMKIRDEPESKDIPVEKRKFQIKKSDDEKMQAFGWANISITADGEVLEDLQHDIIEPEELEQAAYKFVDLYREGGEMHIRGGVARLIESAVFTKEKMEAMGIPEGTLPTGWWIGFQVTDADVWEKVKDGTYSMFSIEGEAKRVEVEDEESDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BBI8</accession>
    <name>A0A174BBI8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CysJI operon transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cysL_2</name>
        <name evidence="2" type="ORF">ERS852478_01522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200121.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97028">
        <property type="protein sequence ID" value="CUN97028"/>
        <property type="gene ID" value="ERS852478_01522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="1">
        <location>
            <begin position="28"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN97028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="241" mass="27467" checksum="9EB5A9FBD5263855" modified="2016-09-07" version="1">MVYQLYDSAFRILDIRNNLLENFTGSRKQIIDLAASTIPSSYLLPELLAGFGRMYPDVYFHSWQTDSSGAINRVLDGTVDLALTGQNTGDDSYVFIPFCQDNMVIATPVNDHYLNLKQKEQPVVFQDFIKDPVIIREKGSGTKKEMDIFLENAGIEPSSLNVVARMNDLESIKKSIVNGLGFSILSARSVVDLQKTKQILLFPLEESAHKHSFYIVYSKNRILKSHVRQFIHYVKEYYQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BC06</accession>
    <name>A0A174BC06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN98297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005361149.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98297">
        <property type="protein sequence ID" value="CUN98297"/>
        <property type="gene ID" value="ERS852478_01558"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN98297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="117" mass="14348" checksum="9260F7722B611376" modified="2016-09-07" version="1">MKKAETQEQEFLEVCSSYDHDLLTGKKEMTLKDYERITYLVSSLGYSQYLQFLIGKYMDLAQADEEREEREHEIYLEYPEYYEDEGILEEEEKWLEEFLNQLPEKKREYFEKLIKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BKI2</accession>
    <name>A0A174BKI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Linear gramicidin synthase subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lgrD</name>
        <name evidence="6" type="ORF">ERS852478_01614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057324.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01167">
        <property type="protein sequence ID" value="CUO01167"/>
        <property type="gene ID" value="ERS852478_01614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="14"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_4" evidence="5">
        <location>
            <begin position="129"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO01167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="497" mass="57800" checksum="CA1876AAEAF438A0" modified="2016-09-07" version="1">MDEKRKEQFYQNIVYDAWKDTLQDNTFDIDDNFFDLGGSSLQAIAIISKLSERFEVDIPQFFANPTIRNIAANLKEDANIMLRKFEQTFAFKQLKEINETEKREYQKKYAKVNNVKKEDDKYKDVLLLGATGFLGIYLLHQLLLESVATITLLIRADSMRQAQNRIKKHYEYYFGNGSYDQYSHRIKIIIGDLTLDMFGLTENEYKELANHIEAIINSAALVKHMGKNSEFELINVKIVENIVDFAKNGINKDIHHMSTIGIVYGANMEKSKTIFTEYDESTLDGLENQYLRSKVKAEKVLKNAKNQGVQSSIYRMSGILFDSKTGKYQINVNESSAYIYYRNLYRLRIVPSEIQRKMDISCVDKISEAVVKLILSDDRSNDVYHVINPNGLTIKEILNCFKDCENNKDIIMKELSVEEIYNYYKKTDTKEQELFKQLVFECEIVNDIGKCDLNIGGDRTIFILEQLGFKWEKVGREEIIRAYHAIRESKKSGKKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C0H1</accession>
    <name>A0A174C0H1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Citrate lyase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200193.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05829">
        <property type="protein sequence ID" value="CUO05829"/>
        <property type="gene ID" value="ERS852478_01731"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028157">
        <property type="entry name" value="PELOTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011215">
        <property type="entry name" value="PRTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15608">
        <property type="entry name" value="PELOTA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11202">
        <property type="entry name" value="PRTase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020979">
        <property type="entry name" value="UCP020979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PELOTA_1" evidence="1">
        <location>
            <begin position="265"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO05829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="350" mass="39572" checksum="4F0C6A44005517AD" modified="2016-09-07" version="1">MRSSYSEEDVILLLKDITGMVEPQPAKVREKLIQSGKHYSEMLPVEYVPTDQYMQVYHNALKHYAKPVANAVGMLADKIIENKGKKIVLVSLARAGIPIGILVKRYIKFKYDINVPHYSISIIRGRGIDDNAMKYLLEKYRPQQILFVDGWIGKGAILNELKKDISAYEGVSADIAVVADPANVTELCGTHEDILIPSSCLNSTVSGLISRTFLRDDIIGRDDFHGAVYYGELTDSDLSYDFIETIEKEFNMENTPDLEKRVESQGIDEVINIGKNFGVDDINLIKPGIGETTRVLLRRIPWKVLIDERYKGNPQLEHIVRLAEEKHTPVEYYPLTHYKCCGIIKKLADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C3Y7</accession>
    <name>A0A174C3Y7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nudC</name>
        <name evidence="9" type="ORF">BWLFYP14_01215</name>
        <name evidence="8" type="ORF">ERS852478_01796</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026649297.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07854">
        <property type="protein sequence ID" value="CUO07854"/>
        <property type="gene ID" value="ERS852478_01796"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000210">
        <property type="term" value="F:NAD+ diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="zf-NADH-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="152"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO07854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX63864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="282" mass="32932" checksum="50CE29466A5DC5D0" modified="2016-09-07" version="1">MIQDIAPHTYHNEYKPSAPDKNSFILAYEKGSILLPHQEREADIYFPRFQDLEEKVSDLYSKYIYLFSIDDQRFYLIPELDTTLLPDYEFQDIRNLRTARPQHLAFAGVTGHQLFQWYSKRRFCGCCGKPMLHSQKERMMECPSCGNQEYPVLCPAVIVGITNGDKIILSKYEGRRFKRYALIAGFAEIGETIEETVHREVMEEVGLKVKNLRYYKSQPWSFSGTLLFGFFCDVDGDDTLTVDHEELSMAQWVERDKIPDQGNNISLTKEMMMLFRDGKEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C431</accession>
    <name>A0A174C431_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_01806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200282.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08172">
        <property type="protein sequence ID" value="CUO08172"/>
        <property type="gene ID" value="ERS852478_01806"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO08172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="256" mass="27982" checksum="66E6BB287F4E0AB0" modified="2016-09-07" version="1">MKWQNAIVRDFDQKGYVNEMYILTALVAFAGSFVQSSSGFGYAIICMAIWPMFMPFYTASILEAIAAFFMVIYIAVRLWKFIDWKLLLPPVIMATVTSFLGVNTLMALDEDVLSKIMGTVLLILAVYFIFFSSKVHLKASLVSGLVAGAISGFCGGLFNIGGPPMVAYFLSVTDDKEKYNATLQMFFTINTISIFLIHVFQGHVSGSMLPLVGAALAGTAVGTAGGMFLFRRLTMAGIKKTVYIFMICAGSYLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C4A7</accession>
    <name>A0A174C4A7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01800</name>
        <name evidence="4" type="ORF">GT728_05530</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000009">
        <property type="protein sequence ID" value="MZL32680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200272.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07984">
        <property type="protein sequence ID" value="CUO07984"/>
        <property type="gene ID" value="ERS852478_01800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="215"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO07984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="401" mass="47370" checksum="6DA7FAB67246D10F" modified="2016-09-07" version="1">MIIERKEYLEKLIAWKDKQLIKIVTGVRRCGKSMLLEIYRNYLKEHGIEEEQIISINFEDLDYEELTDYRKLYKYLKERLIDGKMTYIFLDEIQNVTDFPKVLDSLYIKKNIDIYVTGSNAYMLSSEIATMISGRYIQIEMLPLSFKEYMESTGSMNDRGIKYAEYLQNSSFPFTLELKNQPDEIRDYLEGIYNTIVVKDIINRKKITDTMMLKSVLRFVFDNIGNPLSSKKIADTMTSEGRKIDTKTVEKYLEAFSESYIIYQAKRYNIKGKQYLKTLEKYYIVDIGMRYMLLGSRQADAGHVLENIVYLELLRRGYDVYVGKINSYEVDFVAQNKKGTVYFQVALTVRDENTLLRELRPLQAIRDHYPKIILTMDEEPEEQYEGIRRINARDWLLGIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C5S5</accession>
    <name>A0A174C5S5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fabG_2</name>
        <name evidence="3" type="ORF">ERS852478_01773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200253.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07108">
        <property type="protein sequence ID" value="CUO07108"/>
        <property type="gene ID" value="ERS852478_01773"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO07108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="245" mass="27564" checksum="232030AB6BE96897" modified="2016-09-07" version="1">MSKVTVITGGTSGIGRGIVEKILANSAEDDLIFATYAHNAYKANEFWDSLKPEDQEKLIILKADMSSYDDMMNFVGEVKEKAGHVDWLISNAGISTYDKFQDYTFEEWNKIVNTNLSVPVFMIKEFMPVMTEGGRVLFMGSYAGQQAYSSSLVYGVTKAAIHFLTKSLVKEFEPKGITVNAIAPGFIQTPWHENRTPESYERINRKIALHRFGEIKDVADMAYSILTNNYMNGSIVDIHGGYDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C632</accession>
    <name>A0A174C632_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="9">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">glgC_3</name>
        <name evidence="9" type="synonym">glgC</name>
        <name evidence="11" type="ORF">ERS852478_01781</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057949.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000089.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07350">
        <property type="protein sequence ID" value="CUO07350"/>
        <property type="gene ID" value="ERS852478_01781"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-D-glucose 1-phosphate binding" evidence="9">
        <location>
            <begin position="181"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="9">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO07350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="379" mass="41446" checksum="34A665BA9DB27B78" modified="2016-09-07" version="1">MKQNSMLAMILAGGRGSRLHDLTNKVAKPAVSYGGKYRIVDFPLSNCANSGVDVVGVLTQYESIQLNSYVAAGGRWGLDAKNSGVYVLPPREKADENLNVYRGTADAISQNIDFIDKFDPEYVLVLSGDHIYKMNYDKMLAAHKEAKADATIAVIGVPMKEASRFGIMNTDESGRIVEFEEKPEHPKSNLASMGIYIFTWKLLRKMLMADIKNPDSSHDFGKDIIPTMLNDNRTLYAYKFEGYWKDVGTIDSLWEANMDLLSSKNELDLGDPSWKIYTEDVAALPQYISAEADVKDAYITQGCVVQGEVKHSVLFTGVKIGAGARIIDSVLMPGVVVEEGAVVQRALVADGIRIGKGAVVGAADSEHIELVAKRVKGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CB79</accession>
    <name>A0A174CB79_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10283">
        <property type="protein sequence ID" value="CUO10283"/>
        <property type="gene ID" value="ERS852478_01849"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO10283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="99" mass="10963" checksum="FA5A0F0A4735F965" modified="2016-09-07" version="1">MVPEVKGLSLPEIEDCIEKTELNVSIYPGLSNLDQIQGIDTESAIGEEGKATFDVRTYIMVVIAWFTGLNQQIRIPAWTAILIILVVLPSLYETLLGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CHF6</accession>
    <name>A0A174CHF6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0246 protein ERS852478_01880</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yaaA_1</name>
        <name evidence="2" type="ORF">ERS852478_01880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0246 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200417.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11218">
        <property type="protein sequence ID" value="CUO11218"/>
        <property type="gene ID" value="ERS852478_01880"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00652">
        <property type="entry name" value="UPF0246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO11218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="253" mass="29339" checksum="BE66ED675EAD3C6B" modified="2016-09-07" version="1">MKIILSPAKKMITDTDSIAPDGLPEFIEKTTEIQSWLKSKSKEELKTIWKCNDKITEQNFNRLENMDLYHLLTPAVLSYEGIAFQYMAPSVFEDSQLEYVQNHLRILSAFYGVLKPLDGVTPYRLEMQAKVGIGDAKNLYEYWGDMLYCSVIDNSRIIINLASKEYSKSIEKYLTLRDKYITIVFCELSGDKLVTKGTYAKMARGEMVRFMAENSIENPEDIKKFDRLGYAFRHDLSSDTEYIFERRIEITSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CIC0</accession>
    <name>A0A174CIC0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3793 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF3793)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01924</name>
        <name evidence="3" type="ORF">GT712_02710</name>
        <name evidence="2" type="ORF">GT728_10715</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 5 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A1</strain>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000023">
        <property type="protein sequence ID" value="MZL33657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS88024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060011.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12677">
        <property type="protein sequence ID" value="CUO12677"/>
        <property type="gene ID" value="ERS852478_01924"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SGE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024523">
        <property type="entry name" value="DUF3793"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12672">
        <property type="entry name" value="DUF3793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO12677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL33657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS88024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="183" mass="20973" checksum="FCB5E319CABF27DA" modified="2016-09-07" version="1">MLEKSVIEHCSPTLASIKTGNLFTYKYESEEELWKSVEGFNECVREKGVSLTVLRRSEKKALIYVCRFSSLERDLKKPGVANFIKKYGYESTDPAYALERLRSRLAQREDFPHEIGLFLGYPLGDVIGFIKNAGQNCKCVGCWKVYCNECEAIKAFARFKKCTSVYVRLWNQGRTVRQLTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CJR8</accession>
    <name>A0A174CJR8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">General stress protein 69</fullName>
            <ecNumber evidence="6">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yhdN</name>
        <name evidence="6" type="ORF">ERS852478_01900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577088.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000156.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11796">
        <property type="protein sequence ID" value="CUO11796"/>
        <property type="gene ID" value="ERS852478_01900"/>
    </dbReference>
    <dbReference type="GeneID" id="66493894"/>
    <dbReference type="eggNOG" id="COG1453">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO11796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="335" mass="37157" checksum="6902C36932EF7719" modified="2016-09-07" version="1">MEYVTLGKTGLRVSRMGLGGIPIQKIDAEGTKTLLHKLADRGVNYIDTARGYTVSEEYLGYALEGIRDRFIIATKSMARTKEAMAEDIEKSLHNLRTDHIELYQVHNPSMEQLDQVQAAGGALEALQEARAAGKIGHIGLTAHSVEVFARALELDWVETIMFPYNIVESQGEELISKCEEKNIGFIDMKPLAGGAIENGTLALRYVCSNKNVTIVIPGMAEEKEIEENIKACLDDSPLSEKELEEVQTVRNQLGTNFCRRCNYCAPCSVGIDISGVFLFAGYLNRYGLGDWARNRYSSLAVKASACIECGKCETRCPYHLPIREMLKECAQQFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CN92</accession>
    <name>A0A174CN92_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Argininosuccinate synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">GMP synthase subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02193</name>
        <name evidence="3" type="ORF">ERS852478_01940</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200460.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13116">
        <property type="protein sequence ID" value="CUO13116"/>
        <property type="gene ID" value="ERS852478_01940"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01990">
        <property type="entry name" value="Alpha_ANH_like_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005232">
        <property type="entry name" value="LarE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43169:SF2">
        <property type="entry name" value="PTHR43169:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006661">
        <property type="entry name" value="PP-lp_UCP006661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00268">
        <property type="entry name" value="TIGR00268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile and sulfur donor" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006661-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO13116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="282" mass="31702" checksum="E46EF888FF806C8D" modified="2016-09-07" version="1">MENKLEHLKEYLKGLGSVAVAFSSGVDSTFLLKVAHDVLGDKAIAITAQSCSFPKRELNEAKAFCEKEGIQHVICQSEELEIEGFSKNPPNRCYLCKKELFEKIGDIAKKNGIEYIAEGSNMDDNGDYRPGLIAVKELGVKSPLCEAKLTKAEIREYSKELGLPTWDKQSFACLSSRFVYGETISEEKLGMVEKAEQLLLDYGFHQVRVRIHGSLARIEIMPEEFPKLLEKNVREDIAKKFKEYGFTYVTMDILGYRMGSMNETLGENDKTTADSSLKGKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CPE0</accession>
    <name>A0A174CPE0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02178</name>
        <name evidence="2" type="ORF">ERS852478_01955</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13595">
        <property type="protein sequence ID" value="CUO13595"/>
        <property type="gene ID" value="ERS852478_01955"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032HW3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO13595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="481" mass="53951" checksum="E65F4F5A043C400A" modified="2016-09-07" version="1">MRLEDMKKDIPETPEFIHTMIQSEVKKQLQDTKVVNIQTRRVKKWTGARVAAAIAVCVLATSTIVYAGTKLYHMFLEKQGAYSIVTGIKADGSTGKINLPERIHDIDISAGYIPEGMEWIDEFHLEYPEHDRTGGFSFASVLLDEDDLSKVMQDKNVVDCEERTFGNYEGVYLKYNDLAEDGSFNQRIYLLRPDVYRVITVYIGDDISKEDAIKVVENLVITENDTMIETAGLYTWSEMVSPEESSGEAVMTSIADNKLLMHQIGEVFDISASGEDRDGNYIENDKISVCVDAVQVEDNLQLLGQNNVPEEWTDAVGTDGNLVNNTLSYIKSGNGIDSVDEIVKTESVKQKLVYATVTYTNKSDEEINHMLYIGTLLLMDHEDGSYQIYDPTEQSGDDYDRVIWDGVARTAEMTYNSISEDYGNGGNYISSLKPGESIQVNMAWIVNENDLNNMYLNLNGDGAAYEFSDSMLKTGLVDIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CT66</accession>
    <name>A0A174CT66_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Epoxyqueuosine reductase QueH</fullName>
            <ecNumber evidence="5 12">1.17.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Queuosine biosynthesis protein QueH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">queH</name>
        <name evidence="13" type="ORF">ERS852478_01977</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:32159"/>
            <dbReference type="Rhea" id="RHEA-COMP:10345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82831"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="1.17.99.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the QueH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.99.6" evidence="5 12"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15008">
        <property type="protein sequence ID" value="CUO15008"/>
        <property type="gene ID" value="ERS852478_01977"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052693">
        <property type="term" value="F:epoxyqueuosine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02089">
        <property type="entry name" value="QueH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003828">
        <property type="entry name" value="QueH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36701">
        <property type="entry name" value="PTHR36701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02677">
        <property type="entry name" value="QueH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="195"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO15008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="208" mass="24706" checksum="F9F6696515EBCC3A" modified="2016-09-07" version="1">MNKRNYQKELEKLIDQAQKDNKIPSLFLHSCCAPCSSYVLEYLSKYFNITVFYYNPNIYPEEEYRKRVHEITRLVNSMEFEHPVKLIEGHYDPQEFFQMAKGLEDVPEGGERCFKCYRLRMEEAAKLAEEGGYDYFTTTLSISPLKNAAKINEIGQELAEIYHVQHLPSDFKKKNGYKRSIELSHEYDLYRQNYCGCVYSRREAENRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CZM4</accession>
    <name>A0A174CZM4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted ATPase (AAA+ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200509.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17056">
        <property type="protein sequence ID" value="CUO17056"/>
        <property type="gene ID" value="ERS852478_02041"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008533">
        <property type="entry name" value="DUF815"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05673">
        <property type="entry name" value="DUF815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF815" evidence="1">
        <location>
            <begin position="185"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO17056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="435" mass="49643" checksum="CE167A640446E076" modified="2016-09-07" version="1">MARLNECILYRNFEHGEILDKMAELMNAWEQNAPDLKEKEGLFFECANGLVETAGSYGFSGNLWHCYLTFLLVNNENAFSTACEIRGAVNGSINELALNDFGVFKELYDFDLTVLDEAFGISCCKVLGDYTNTGSNSKMFNSRIRDRICDLSKTLAAAESTEEFMKDMVQFYKDFGVGKLGLHKAFRVGHDENDNVEIQPITRIAHVKLEDLVGYEIPKQKLIENTEAFVRGRKANNCLLFGDAGTGKSSSIKGILNRYYDEGLRIIEVYKHQFQDLNDVIAQIKNRNYKFIIYMDDLSFEEFEIEYKYLKAVIEGGLEKKPDNILIYATSNRRHLVREKSSDKLEIMDDDDLHSSDTVQEKLSLVYRFGVRIYYGAPSKKEFQTIVKALAERNGITMPEDELLLEANKWELSHGGLTGRTAQQFIDHLLGVEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D1Y0</accession>
    <name>A0A174D1Y0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02097</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200559.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19453">
        <property type="protein sequence ID" value="CUO19453"/>
        <property type="gene ID" value="ERS852478_02097"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043780">
        <property type="entry name" value="DUF5722"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013378">
        <property type="entry name" value="Listeria/Bacterioides_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042229">
        <property type="entry name" value="Listeria/Bacterioides_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18989">
        <property type="entry name" value="DUF5722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09479">
        <property type="entry name" value="Flg_new"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02543">
        <property type="entry name" value="List_Bact_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019648" evidence="2">
        <location>
            <begin position="29"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5722" evidence="3">
        <location>
            <begin position="441"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO19453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="829" mass="91780" checksum="460E4F7C07ABC2FE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D2D3</accession>
    <name>A0A174D2D3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200565.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19811">
        <property type="protein sequence ID" value="CUO19811"/>
        <property type="gene ID" value="ERS852478_02108"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO19811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="442" mass="51615" checksum="56DA14B8E1D5A3DF" modified="2016-09-07" version="1">MQIISSYGVELRKQNIPIRQTLEIYRSAVSYLIGIYVQVWEELAEIPDAKRRFNAAEHLVHTTKKNHACFDFDIRFPKMPSYLRRSAIQHALGTVSSYKTRLDLWEKTDGKSGKPKLVYENHAMPVFYRDVMYREGAEGKDEAYLKLYDGHDWKWSCVRLDHTDMEYLRKCWSGKKASAPTLEKRHQKYFLRFSYKEEVTLTKTPVKEQIICSVDLGINTDAVCTIMRADGTVLGRRFIDHPSEKDRMYRTLGRIRRSQREHGSAQTQGRWAYTKRLNTELGKKTAGAIVRYAEENHADVIVFEYLEMQGKISGKKKQKLHLWRKRDIQKCCEHQAHRKGMRVSRICAWNTSRLAYDGSGTVTRDRENHSLCTFQTGKRYNCDLSASYNIGARYFIRELLKPLPATERSLLEAKVPPVKRRTSCVYADLRKLYSEMERLKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D566</accession>
    <name>A0A174D566_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200543.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19148">
        <property type="protein sequence ID" value="CUO19148"/>
        <property type="gene ID" value="ERS852478_02088"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO19148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="326" mass="37878" checksum="87754BA73B00F9F7" modified="2016-09-07" version="1">MHNFKKVLKTFLVLVVCVALLAALDLALYPCTFMRNDVHAVVTQQFDDIIVGTSHGKMDIDPEVMQEVTGHSGHNLCVGGEYGIDAYYLTKLIKEKQNPKRIIYEVDPGYFVSEKEEGNNYLLFYHEFPFSKAKVEYFWNSIAKCNFRTVLFPWYEYSLSYELPKVKDTFTQKVTGDYDVSHLKSDSQEYHESGFIERYPVDVTKLKKSEPKLYEEGKVNEENMEYLKKLITFCKENDIEFVAVTTPIPINTLKDYSDSYNAAWKYFGQFFEEQGVEYLNFNTQYFKAFTHDLKAYTDYDGHMNGDAAKEYSEVLAQVLESAGQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D591</accession>
    <name>A0A174D591_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cardiolipin synthase</fullName>
            <ecNumber evidence="14">2.7.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cls_3</name>
        <name evidence="15" type="synonym">cls</name>
        <name evidence="14" type="ORF">ERS852478_02129</name>
        <name evidence="15" type="ORF">GT712_11515</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="14"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060226.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20407">
        <property type="protein sequence ID" value="CUO20407"/>
        <property type="gene ID" value="ERS852478_02129"/>
    </dbReference>
    <dbReference type="GeneID" id="66495356"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022924">
        <property type="entry name" value="Cardiolipin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04265">
        <property type="entry name" value="bac_cardiolipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO20407.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZS89683.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="519" mass="59433" checksum="F6CA20CE5A63ECF4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D8E5</accession>
    <name>A0A174D8E5_9FIRM</name>
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        <name type="scientific">Blautia wexlerae</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
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            </authorList>
            <dbReference type="PubMed" id="31477907"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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        <location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="477" mass="55397" checksum="0CF23E97CD6FCFE5" modified="2016-09-07" version="1">MKKHKICKILLVILAIFLCVAFYELLGICVAYKKQPEVSNTTKKETKNGLWNECSENTERAVIIEKNPEALLQRVRLIKNAKKEIILSTFAFQSDESGKLILGALHDAADRGVHIRLLVDGMESWIDMEGNPYFYGLSSHENVEIKLYNKANPLKPWKMMGRMHDKYLIADGKRYILGGRNTYNYFLGDFPGHKNYDRDVLVVCDEPEKENSVNQLSEYFETIWNQEDSGYFHNNKKLANRKSVKNAVLELQNSYQKYFEENKERICETDYTDETFETEKITLVSNPIHTGSKEPVVWYQLGELMKNAKNRVKIHTPYIICNDMMYNTWEEIAENVSDFSIMTNSVANNGNPFGAADYAKNRNRILSTGINIWEYEGGYSYHGKSILIDDDLSVIGSFNMDMRSAYLDTELMLVIRSKDINKQLEEGMMEYEKVSRQILEGGTYNDPYHVEPIELTKKRQRKIFLVQHLLGWARYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D9P8</accession>
    <name>A0A174D9P8_9FIRM</name>
    <protein>
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        <name evidence="11" type="ORF">BWLFYP14_02848</name>
        <name evidence="7" type="ORF">ERS852478_02187</name>
        <name evidence="8" type="ORF">ERS852523_01711</name>
        <name evidence="10" type="ORF">GT712_11385</name>
        <name evidence="9" type="ORF">GT728_11225</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
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            </authorList>
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            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CUO22264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUP46804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZL33753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="CABHOF010000060">
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    </dbReference>
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        <property type="gene ID" value="ERS852478_02187"/>
    </dbReference>
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        <property type="gene ID" value="ERS852523_01711"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="MZS89658.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VUX66473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="44" mass="5065" checksum="8040C44EDE2EC5CF" modified="2016-09-07" version="1">MKMTFQPKKRSRAKVHGFRARMSTKGGRKVLAARRLKGRKHLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DAI6</accession>
    <name>A0A174DAI6_9FIRM</name>
    <protein>
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        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
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        <name evidence="7" type="synonym">murA</name>
        <name evidence="13" type="ORF">BWLFYP14_02861</name>
        <name evidence="9" type="ORF">ERS852478_02200</name>
        <name evidence="10" type="ORF">ERS852523_01698</name>
        <name evidence="12" type="ORF">GT712_11320</name>
        <name evidence="11" type="ORF">GT728_11160</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000015">
        <property type="protein sequence ID" value="CUP46458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000025">
        <property type="protein sequence ID" value="MZL33740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707990.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000021_gene1708"/>
    <dbReference type="EnsemblBacteria" id="CUO22661">
        <property type="protein sequence ID" value="CUO22661"/>
        <property type="gene ID" value="ERS852478_02200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP46458">
        <property type="protein sequence ID" value="CUP46458"/>
        <property type="gene ID" value="ERS852523_01698"/>
    </dbReference>
    <dbReference type="GeneID" id="66493392"/>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetylglucosamine binding" evidence="7">
        <location>
            <begin position="122"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO22661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP46458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL33740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS89645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX66486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="430" mass="46155" checksum="73882FD739BDCCF0" modified="2016-09-07" version="1">MEQYVIKGGNPLVGEVEIAGAKNAALAILAAAIMTDETILIENLPDVRDINVLLEAIAGIGAQVDRIDKSTVKINGSTIGDVSVDYEYIKKIRASYYLLGALLGKYKHAEVPLPGGCNIGSRPIDQHLKGFRALGADVDIMHGAIVAKADELHGSHIFLDVVSVGATINIMMAASLAPGRTILENAAREPHVVDVANFLNSMGANIKGAGTDVIRIKGVEKLHRTEYSIIPDQIEAGTFMFAAAATGGDVTVKNVIPKHLEATTAKLEEIGCEVEEFDDAVRVRAPKRLHRTHVKTLPYPGYPTDMQPQIAVTLALAEGTSIVTESIFENRFKYADELSRMGANIKVEGNSAIIDGVKKLTGARVSAPDLRAGAALVIAGLAADGITVVDDIVYIQRGYENFEDKLRSLGAEIERVSNEKEIQKFRLRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DGZ2</accession>
    <name>A0A174DGZ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02253</name>
        <name evidence="3" type="ORF">ERS852523_03983</name>
        <name evidence="4" type="ORF">GT712_19855</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000073">
        <property type="protein sequence ID" value="CUQ10587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000095">
        <property type="protein sequence ID" value="MZS91219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002323342.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000162.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24723">
        <property type="protein sequence ID" value="CUO24723"/>
        <property type="gene ID" value="ERS852478_02253"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ10587">
        <property type="protein sequence ID" value="CUQ10587"/>
        <property type="gene ID" value="ERS852523_03983"/>
    </dbReference>
    <dbReference type="GeneID" id="61927964"/>
    <dbReference type="GeneID" id="64195709"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO24723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ10587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS91219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="73" mass="8007" checksum="E8C74943DCE2A9B8" modified="2016-09-07" version="1">MNFGQNLYQWFLSNAQSLVLMAIVVIGIYLGFKREFSKLIGFLVVALIAVGLVFNAGGVKDVLLELFNKIIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DK99</accession>
    <name>A0A174DK99_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-xylosidase</fullName>
            <ecNumber evidence="4">3.2.1.177</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yicI_5</name>
        <name evidence="4" type="ORF">ERS852478_02287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.177" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200677.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25864">
        <property type="protein sequence ID" value="CUO25864"/>
        <property type="gene ID" value="ERS852478_02287"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061634">
        <property type="term" value="F:alpha-D-xyloside xylohydrolase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="48"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO25864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="650" mass="74298" checksum="3D9AD201452A0F30" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DLE0</accession>
    <name>A0A174DLE0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Ribose import ATP-binding protein RbsA</fullName>
            <ecNumber evidence="5">3.6.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rbsA_3</name>
        <name evidence="6" type="synonym">rbsA_2</name>
        <name evidence="9" type="ORF">BWLFYP14_01546</name>
        <name evidence="5" type="ORF">ERS852478_02300</name>
        <name evidence="6" type="ORF">ERS852523_01641</name>
        <name evidence="8" type="ORF">GT712_12860</name>
        <name evidence="7" type="ORF">GT728_12175</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.17" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP44491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000029">
        <property type="protein sequence ID" value="MZL33935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705558.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000081_gene3048"/>
    <dbReference type="EnsemblBacteria" id="CUO26244">
        <property type="protein sequence ID" value="CUO26244"/>
        <property type="gene ID" value="ERS852478_02300"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP44491">
        <property type="protein sequence ID" value="CUP44491"/>
        <property type="gene ID" value="ERS852523_01641"/>
    </dbReference>
    <dbReference type="GeneID" id="66494417"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="254"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO26244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP44491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS89938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX64692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="503" mass="55951" checksum="A833498BBE43BF73" modified="2016-09-07" version="1">MGEVILTMKDIDKSFPGVHALDHVNFEVKRGEVHALMGENGAGKSTLMKVLTGIYQKDSGSITYKGKETEFHNTREAQDAGVVIVHQELNMVGDLTVAQNIFIGREPKKGFSIDDKKMIEDSKKLFQELNIEINPKEKMNNLTVGKQQMCEIAKAISHKAEVIIFDEPSAALTEKEIADLFEIIRDLRKKGLGIVYISHRMDEIKTITDRVTVMRDGGYVGTLITADSTKEDIINMMVGRVIYEDPKEHSMVAPDAPVVLKVENLNAGKMVQNVSFELRKGEILGFSGLMGAGRTETARALFGADPKQSGKISIRGKDGQLREVTINSPQDAVKYGIGYLSEDRRRYGCVVQKSVTENTTLATMEEFTSGIFINKSKEKEVSEKYVKELATKTPNCEQLVVNLSGGNQQKVVIAKWLTRDSEILIFDEPTRGIDVGAKNEIYKLMNRLAAEGKSIIMISSEMTEVLRMSDRIIVMCEGKITGNIDISEATQEHIMNHATRNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DSV7</accession>
    <name>A0A174DSV7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13 15">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="6 13 15">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">trmD</name>
        <name evidence="17" type="ORF">ERS852478_02358</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13 15">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 15">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 15">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13 15">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="6 13 15"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200709.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28641">
        <property type="protein sequence ID" value="CUO28641"/>
        <property type="gene ID" value="ERS852478_02358"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 13 15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA_m1G_MT" evidence="16">
        <location>
            <begin position="23"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="13 14">
        <location>
            <begin position="133"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUO28641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="252" mass="29072" checksum="708E1A7850A1A9EC" modified="2016-09-07" version="1">MNFHVLTLFPEMIENGMNTSITGRAITKGLLTLEAVNIRDYAFNKHQKVDDYTYGGGAGMLMQAEPVYLAYEAIANRTEKKPRVVYLTPQGQVFNQAMAREMAQEEDLVFLCGHYEGIDERVLEEIVTDYVSIGDYVLTGGELPAMVMMDSISRMVPGVLNNQESGETESFAGNLLEYPQYSRPEEWHGKKVPEVLMSGHHANIEKWRREQSIYRTAKRRPDLLKKADLTNKEWNYVRQLRKQWKEEEEQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DSY9</accession>
    <name>A0A174DSY9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rimM</name>
        <name evidence="6" type="ORF">ERS852478_02359</name>
        <name evidence="7" type="ORF">ERS852523_00966</name>
        <name evidence="9" type="ORF">GT712_13750</name>
        <name evidence="8" type="ORF">GT728_07910</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">2789STDY5834863</strain>
            <strain evidence="7 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">BIOML-A1</strain>
            <strain evidence="9 12">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP23516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000014">
        <property type="protein sequence ID" value="MZL33131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000029">
        <property type="protein sequence ID" value="MZS90107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704681.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1078"/>
    <dbReference type="EnsemblBacteria" id="CUO28671">
        <property type="protein sequence ID" value="CUO28671"/>
        <property type="gene ID" value="ERS852478_02359"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23516">
        <property type="protein sequence ID" value="CUP23516"/>
        <property type="gene ID" value="ERS852523_00966"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="5">
        <location>
            <begin position="93"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO28671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP23516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL33131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS90107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="167" mass="19285" checksum="59E6901679C538A0" modified="2016-09-07" version="1">MEDLLKVGVITTTHGIRGEVKVYPTTDADRFLDLEYVLLDTGREKRKLEIENVKYFKNLVILKFRGIDNINDIEMYKKRELWIPREEAQELEEDEYYIADLIGMDVVLEDGSKFGTLKDVMETGANDVYVVEDAKGEEILLPAIRECILDVDVEKNVMTIHLMKGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DUC1</accession>
    <name>A0A174DUC1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200725.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29161">
        <property type="protein sequence ID" value="CUO29161"/>
        <property type="gene ID" value="ERS852478_02374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO29161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="761" mass="85051" checksum="DCE8BAE6E9C13004" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E941</accession>
    <name>A0A174E941_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Low molecular weight protein-tyrosine-phosphatase yfkJ</fullName>
            <ecNumber evidence="5">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yfkJ</name>
        <name evidence="5" type="ORF">ERS852478_02534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO34173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380367.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34173">
        <property type="protein sequence ID" value="CUO34173"/>
        <property type="gene ID" value="ERS852478_02534"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="4">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO34173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="158" mass="18155" checksum="04384AA1666D46F2" modified="2016-09-07" version="1">MIRVLFICHGNICRSPMAEFIFKDMVSKQGLSDRFYIASAATSTEEIWNGIGNPVYPPAREELAKHGIDCKGKRAVQLTKADYDKYDYILGMDHWNLKNMLRILKSDPEDKVKLLLDYSDDPRDIADPWYTGGFDVTYSDVVEGCEAFLEYLKDKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EAD8</accession>
    <name>A0A174EAD8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TcpE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO34802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003061368.1">
        <property type="nucleotide sequence ID" value="NZ_WWVP01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34802">
        <property type="protein sequence ID" value="CUO34802"/>
        <property type="gene ID" value="ERS852478_02538"/>
    </dbReference>
    <dbReference type="GeneID" id="61850943"/>
    <dbReference type="GeneID" id="64112564"/>
    <dbReference type="eggNOG" id="ENOG502Z89W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025608">
        <property type="entry name" value="TcpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12648">
        <property type="entry name" value="TcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO34802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="132" mass="15284" checksum="D68BF9411D308640" modified="2016-09-07" version="1">MKKIKSYTGIWNVEKVLYAINDFNLPFPVTFTQITWFVITEFIIILFGDIPPLSMIEGAFLKYFGIPVALTWFMSQKTFDGKKPYSFLKSQITYALRPKITYAGKAVKLHKQILNETITAVRSVNYVPDKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EAQ4</accession>
    <name>A0A174EAQ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33529">
        <property type="protein sequence ID" value="CUO33529"/>
        <property type="gene ID" value="ERS852478_02512"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033VY0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020577" evidence="2">
        <location>
            <begin position="29"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO33529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="403" mass="44926" checksum="DDC365E60E0C2915" modified="2016-09-07" version="1">MNINKHLILLFSVLFFLFAVSVSSGCFRKNESDVKSVVRNELDQLKNLDSETTQKYIPYTELFPDATENTDLTDEINKTFSLFFRKFNYKISDVIVGTTNHSATVSVKLTTIDSKVLARDFKAELLRTQITESAQAQKGNIKDSSRSLEAHYLILNHLLNTNDYDTAETDCNIQLVNTGNDKKEKWKIQRTNSLEDDLVGGLIADLADPDILSPEDTLTVYLDTLQKLDLKEMTSYLGVVNIMNTSDTAKNSIASALAEQIHKNFNYVIKSSSENGYNATVTTEITTFDSDSILADYQEKLDKYLASADAVIDGSQKRYEKSFEILLNSINDNTVTTVNDVDFVLINDGVSWKLQDEGNTLGNAIFGTLTDSPLETSDSEDENISADTDKQTDDNTSTESSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EHV8</accession>
    <name>A0A174EHV8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA decarbonylase/synthase complex subunit delta</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">C/Fe-SP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">acsD</name>
        <name evidence="2" type="ORF">ERS852478_02581</name>
        <name evidence="3" type="ORF">GT728_02650</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380766.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36116">
        <property type="protein sequence ID" value="CUO36116"/>
        <property type="gene ID" value="ERS852478_02581"/>
    </dbReference>
    <dbReference type="GeneID" id="66494132"/>
    <dbReference type="eggNOG" id="COG2069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016041">
        <property type="entry name" value="Ac-CoA_synth_d_su_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03599">
        <property type="entry name" value="CdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CdhD" evidence="1">
        <location>
            <begin position="17"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO36116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="314" mass="33059" checksum="BB77C2C48EB03E42" modified="2016-09-07" version="1">MPFNQKLQKFNAKINTVTIGSGDKTVTIGGDSTYPFYSFDAPSENAPKIGVEISDMGLENIVSEGIKAYYDGASTIGEMAKKAAAMEGADFVALILEGGDPNGVNKSVDELIAVVKEVADAIDAPLVVEGCKNVEKDAELLPKVAEALQGRNVLILSEKEENYKAIGAAAGLAYDQIVGAESAVDINLAKQLNVVTTQLGVNAQKIVMNIGSAAAGYGYEYVVSTMDRIKGAALSQNDNMLQMPIITPVSAETWGVKEATASEKDMPEWGPEEERGIDMEVMTAAADLAAGSDAVILRHPEAVAAISRMIKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ETY9</accession>
    <name>A0A174ETY9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Putative multidrug export ATP-binding/permease protein SAV1866</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852478_02744</name>
        <name evidence="11" type="ORF">GT728_09625</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000019">
        <property type="protein sequence ID" value="MZL33451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060236.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41433">
        <property type="protein sequence ID" value="CUO41433"/>
        <property type="gene ID" value="ERS852478_02744"/>
    </dbReference>
    <dbReference type="GeneID" id="66493305"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="338"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="372"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO41433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL33451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="573" mass="65016" checksum="639E4ECBE92A513C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZ72</accession>
    <name>A0A174EZ72_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin reductase</fullName>
            <ecNumber evidence="5">1.8.1.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trxB_2</name>
        <name evidence="5" type="ORF">ERS852478_02772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CUO42587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CYZN01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42587">
        <property type="protein sequence ID" value="CUO42587"/>
        <property type="gene ID" value="ERS852478_02772"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="3"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO42587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="299" mass="31737" checksum="F60D90B5D2825436" modified="2016-09-07" version="1">MKYDVGIIGSGPAGLSAAIYAKRANLSAVVIEKEYEGTGQIAESGQVDNYPGFPGISGYDLGENFREHAVKLGVSFMEQEVTEIKKEASSDFELVFADGSQVEAKTVIYAAGATPQRANIPGEQEYAGKGVSYCAICDGSFYRGKSVAVLGGGDTALDDAVYLADVAEKVYVIHRRKEFRGAAVTVAKLREKENVIFVLEHQVKEIIGEQKVTGVVLEDAAVIDVNGVFVAYGAVPQTDLLKKFAVLDDSGYVRAGETGETALEGLYVAGDARTKKLRQVVTAVSDGANAATAVAEYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZD3</accession>
    <name>A0A174EZD3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_00559</name>
        <name evidence="1" type="ORF">ERS852478_02743</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="VUX62781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993445.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41400">
        <property type="protein sequence ID" value="CUO41400"/>
        <property type="gene ID" value="ERS852478_02743"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO41400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX62781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="102" mass="12523" checksum="05EBF67FA03B3F09" modified="2016-09-07" version="1">MQDRKLEQALEIYFQENPDRESDKYQEIQKYLKLRIRSVMELLIENEDTERMEQIEKCGWFSANELENFIRCAQEKAKLRSLVWLLHLKDKKYGYQKKDFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F257</accession>
    <name>A0A174F257_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized GTP-binding protein YjiA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjiA_1</name>
        <name evidence="2" type="ORF">ERS852478_02787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200922.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43018">
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        <property type="gene ID" value="ERS852478_02787"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="1">
        <location>
            <begin position="6"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO43018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="335" mass="38102" checksum="7341DD28D6B78346" modified="2016-09-07" version="1">MVKIDLITGFLGSGKTTFIRKYAQYLMDAGNNIGILENDYGAVNVDMMLLQDLMGENCELEMISGGCDKDCHRRRFKTKLIAMGMCGYDRVIVEPSGIFDVDEFFDILHEEPLNRWYQIGNVIAIVDPKLERDLSEEADFILASEVADAGCIVMSKSQDASPEEIQGTIEHVNQALEKVHCSRRFHCEMNGVDTANVIHKNWDEMSKEDFDRIASCGYVMASYRKPEFEAEGAFTSLYFMNVKMTEKELREAAEKILSDPECGRVFRMKGFMRVDSDSEDGSGLSAWAECDRRQWIELNATKNEITIRPLHVGQEVLIVIGEELHEEKIKSYLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F9B3</accession>
    <name>A0A174F9B3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type transporter ATP-binding protein EcsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ecsA_2</name>
        <name evidence="5" type="ORF">ERS852478_02911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201019.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46813">
        <property type="protein sequence ID" value="CUO46813"/>
        <property type="gene ID" value="ERS852478_02911"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO46813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="251" mass="28665" checksum="CCE55BFAECA98122" modified="2016-09-07" version="1">MYVNVENVNFAYDKKPILHDINFGMNKGEITGLIGPNGAGKSTMLKLMIKKMKPNNGKIIIGDNDIFSIKRENNPVTFIPDIPVYYEELTVWEHLQFIKALYPENSVTVDSLIREFNLNQHLNKIPSALSKGTLQKLMIALALLRQYDVLLADEPFNGLDPAQTYKFKNTLKNLKKQDKTILISTHLLSLAEDFCDRYIFLYDGRIVEQGTKAEILQKQQMNKETSLEQIYMSLIGEGEHYAGVQKTVMCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FKC7</accession>
    <name>A0A174FKC7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">atpB_2</name>
        <name evidence="11" type="synonym">atpB</name>
        <name evidence="15" type="ORF">BWLFYP14_03547</name>
        <name evidence="12" type="ORF">ERS852478_03032</name>
        <name evidence="14" type="ORF">GT712_01540</name>
        <name evidence="13" type="ORF">GT728_10225</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="13 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 19">BIOML-A1</strain>
            <strain evidence="14 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000021">
        <property type="protein sequence ID" value="MZL33565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993166.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50712">
        <property type="protein sequence ID" value="CUO50712"/>
        <property type="gene ID" value="ERS852478_03032"/>
    </dbReference>
    <dbReference type="GeneID" id="66495470"/>
    <dbReference type="eggNOG" id="COG0356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO50712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL33565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS87807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VUX67272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="252" mass="27083" checksum="0121E6342336EE7A" modified="2016-09-07" version="1">MELDISGARIFFTLPIDVPVLGPLRISETMVVSWIVMILITGLCIWLTHDLKEENISKRQAVAELIVEKANSFVIGNMGEKFRYLIPFVAALFATSVVSNLISLIGLRSPTADLSTEAAWAVVVFIMITAQKIKTSGFGGYLKGFTTPIAVMTPFNILSELATPVSMACRHFGNILSGVVINGLIYGALAVASSALLGLIPGALGDVLSKIPILDVGVPAITSVYFDWFSGVMQAFIFCMLTVMYIANAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FSG2</accession>
    <name>A0A174FSG2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">tig_1</name>
        <name evidence="11" type="ORF">ERS852478_03055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379936.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51776">
        <property type="protein sequence ID" value="CUO51776"/>
        <property type="gene ID" value="ERS852478_03055"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021950" description="Peptidylprolyl isomerase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="10">
        <location>
            <begin position="104"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO51776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="426" mass="46748" checksum="68421B2DDAD946E9" modified="2016-09-07" version="1">MKKKIYLAMLAVCFALTASACGDDGAVITDGTKTEGAADGKKAETGTTRLVSVENVEKYITIGEYKGLTLDNTVDAITDDDVQAQIDEDLKDKAEPVSDAAKEGDLVTVNYTGTKDGQTFDGGTANNYDFVIGDGQMFEEFENGVIGMKKGDTKEIKIDFPSDYADETLAGEEVIYKVTVQNVRREGELTDEWVAKNTDYTTVDDYRESIRSELEKNAKESAQEVLKNTAWSTVLENSEVKEYPQEDVDKAVSEFKKSMEVYAKQADMTLEEFTDSQGISQDDFDEQCQQYAEGKVKQNLIVQGIMDAEGLSLDDKESLQLQDKLVEQMGVSSIAELVGTYGQDYVDESVGLLRVEEFIIKNASVSEKVANGDVLADDADAVAENAEQDSDQNVSDEDTDDSGQDNSDVDENLEEELGTEDVDQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FW66</accession>
    <name>A0A174FW66_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA binding domain, excisionase family</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03126</name>
        <name evidence="2" type="ORF">GT712_02030</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_016218019.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53971">
        <property type="protein sequence ID" value="CUO53971"/>
        <property type="gene ID" value="ERS852478_03126"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030HYC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038148">
        <property type="entry name" value="Tn1545/Tn916_Xis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015122">
        <property type="entry name" value="Tn916-Xis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09035">
        <property type="entry name" value="Tn916-Xis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO53971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS87900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="77" mass="9154" checksum="68C954A65441CDCC" modified="2016-09-07" version="1">MANNKMNIEGKNYSDIPVWRRYTLTIEEAARYYHIGEGKLRTLIDTHPNEDFYVMNGNRALIKREKFERYLDQATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FWY5</accession>
    <name>A0A174FWY5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">graR_2</name>
        <name evidence="10" type="ORF">BWLFYP14_00684</name>
        <name evidence="9" type="ORF">ERS852478_03147</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO54724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000015">
        <property type="protein sequence ID" value="VUX62935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201200.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000098.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54724">
        <property type="protein sequence ID" value="CUO54724"/>
        <property type="gene ID" value="ERS852478_03147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="127"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="127"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO54724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX62935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="223" mass="25102" checksum="D1F79FC9403E8639" modified="2016-09-07" version="1">MKLSKIMIIEDDPVIQGELQTLLNGNGYTTLGVRNFSTVTEQIQDEKPHLILLDIKLPGENGFALCSKIRTFSEVPIIFVTSCNTDMDELNSIMLGGDAFITKPYNTAILLAKIASLLKKTYPAQQQEKIVYGDAVLHLESSSLDYNGRSVELTKNELKILYYLFKNGGKICSRGDMIEYLWDNQLYVDDNALSVNINRIREKLAGIGLTDFIKTKHRQGYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G6H3</accession>
    <name>A0A174G6H3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Autolytic lysozyme</fullName>
            <ecNumber evidence="2">3.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lyc_2</name>
        <name evidence="2" type="ORF">ERS852478_03250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO58112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201250.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58112">
        <property type="protein sequence ID" value="CUO58112"/>
        <property type="gene ID" value="ERS852478_03250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SH3b" evidence="1">
        <location>
            <begin position="396"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="595" mass="63628" checksum="EAC12A4E2A3C7789" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G996</accession>
    <name>A0A174G996_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-fructosidase</fullName>
            <ecNumber evidence="5">3.2.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bfrA_2</name>
        <name evidence="5" type="ORF">ERS852478_03278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO59042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59042">
        <property type="protein sequence ID" value="CUO59042"/>
        <property type="gene ID" value="ERS852478_03278"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="4">
        <location>
            <begin position="111"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO59042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="549" mass="63497" checksum="122DE39F5F21D800" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GCJ5</accession>
    <name>A0A174GCJ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glnA_2</name>
        <name evidence="3" type="ORF">ERS852478_03312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201275.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60234">
        <property type="protein sequence ID" value="CUO60234"/>
        <property type="gene ID" value="ERS852478_03312"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040577">
        <property type="entry name" value="Gln-synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022147">
        <property type="entry name" value="GSIII_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18318">
        <property type="entry name" value="Gln-synt_C-ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12437">
        <property type="entry name" value="GSIII_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="165"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO60234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="699" mass="77595" checksum="95BA53FC3F901F26" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GHA9</accession>
    <name>A0A174GHA9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calcium-transporting ATPase lmo0841</fullName>
            <ecNumber evidence="9">3.6.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852478_03363</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.8" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201326.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61954">
        <property type="protein sequence ID" value="CUO61954"/>
        <property type="gene ID" value="ERS852478_03363"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="667"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="741"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="808"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="839"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO61954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="873" mass="95258" checksum="191563032AEE53AD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H381</accession>
    <name>A0A174H381_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Auxin efflux carrier</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Membrane transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BWLFYP14_00953</name>
        <name evidence="6" type="ORF">ERS852478_03605</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704291.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69472">
        <property type="protein sequence ID" value="CUO69472"/>
        <property type="gene ID" value="ERS852478_03605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO69472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX63467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="309" mass="33751" checksum="3BE98E8B8EB576FC" modified="2016-09-07" version="1">MNVLEIVLPVLVMIVVGMLCRKWKILTRDGINNMKVLVTNVMLPVAIFHALATAEYNKETGILILIMFVMLVVSFGLGFLLKPFLKGTYQKYLPFMVSVYEGGLMAYPLYTSLCGSENLSRIAVLDIAGLLFGFSVYMGMLGQVENGEKIDVKKLFFSALKTPAFIASILGIIAGLSKVILAVLDSPFGGVYQSVENILTTSVTAIILLVVGYSMELNAKLLKPCIATIILRVLLQAVMIAGVLVAVHYLVGDDRLVNLAIISYMSAPATFSMQTFMKDEEGSAYVSTTNSMYCLVSILVYIIMAVTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H8K5</accession>
    <name>A0A174H8K5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sphR_3</name>
        <name evidence="10" type="ORF">ERS852478_03593</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69175">
        <property type="protein sequence ID" value="CUO69175"/>
        <property type="gene ID" value="ERS852478_03593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="97"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="9">
        <location>
            <begin position="221"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="221"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO69175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="324" mass="37065" checksum="1C0E71901DEF9D9A" modified="2016-09-07" version="1">MNWLTIWVFLKGLFQNGKREFPIVKDTTPNMMNPRLYTTSYNKPQGQQFDTAVLAFIKLQYTEKSCKMINIFVLVTILGHLPVILFAKRKGSEDMKQILIVEDDSFLNKMLAYNLTTDGYGVTSALNARTAAEAIRQREFDLVLLDINLPDGNGFELCKLIKPQHPDTIVIFLTANDQESDQIRGYEVGAVDYITKPFVIEALQRKIKAMFAMLEHHKPAKDIYDDGRLFLDFSEQTASLNGKPLTLSPMEYKMLNLFRKNPRQVLTRGQLLEKLWDIDEKFVDEHTLTTSISRIRSKIESDGGAPYIKTVYGMGYQWTGGEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H9N6</accession>
    <name>A0A174H9N6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4869 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_00073</name>
        <name evidence="1" type="ORF">ERS852478_03655</name>
        <name evidence="2" type="ORF">ERS852523_01680</name>
        <name evidence="3" type="ORF">GT728_01690</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
            <strain evidence="2 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP45600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL31945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704863.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70971">
        <property type="protein sequence ID" value="CUO70971"/>
        <property type="gene ID" value="ERS852478_03655"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP45600">
        <property type="protein sequence ID" value="CUP45600"/>
        <property type="gene ID" value="ERS852523_01680"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032360">
        <property type="entry name" value="DUF4869"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16163">
        <property type="entry name" value="DUF4869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO70971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP45600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL31945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="152" mass="17240" checksum="D5A466E3F0042892" modified="2016-09-07" version="1">MLNIIYGDVKNSIYNTNVYFKNSYEPEWLDAELAKKMIKDIDDSEVLSGECINSPVLGQIPPERLSGGVKTLLLILNEPDRIFNASTCGDNCAKWILEIGRIKDVTINLRHMMSFGKDTKFEIKVQNGGETVHSMKELVPIANKYLNEMKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HGF0</accession>
    <name>A0A174HGF0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">graR_3</name>
        <name evidence="9" type="ORF">ERS852478_03687</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO71985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009264385.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71985">
        <property type="protein sequence ID" value="CUO71985"/>
        <property type="gene ID" value="ERS852478_03687"/>
    </dbReference>
    <dbReference type="GeneID" id="61850956"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="123"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="123"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO71985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="219" mass="25910" checksum="8B8F1E4FDC5CD31F" modified="2016-09-07" version="1">MRIAIIEDDEITRLELSKLLNTQGYETVLLTNFENLTEELKQYCVELVLLDINLPYENGYEVCRKIKQAMPVPIIFVTSRDTNADELKSIQVGGIDFITKPYDTLILLEKIKRALQLSNPNNFRELVKKDCTLDLHLSILKYQEKSIELTRNEFRILYYFFMNEDKVISKEELLEKLWNDKYYLDENVLLVNMTRLKKKMKEIGIVHLLENIRGKGWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JM19</accession>
    <name>A0A174JM19_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative basic amino acid antiporter YfcC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Putative p-aminobenzoyl-glutamate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yfcC</name>
        <name evidence="7" type="ORF">ERS852478_02569</name>
        <name evidence="8" type="ORF">ERS852523_00167</name>
        <name evidence="9" type="ORF">GT712_07225</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
            <strain evidence="8 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000002">
        <property type="protein sequence ID" value="CUO99206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000011">
        <property type="protein sequence ID" value="MZS88862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380777.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000003_gene1583"/>
    <dbReference type="EnsemblBacteria" id="CUO35723">
        <property type="protein sequence ID" value="CUO35723"/>
        <property type="gene ID" value="ERS852478_02569"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99206">
        <property type="protein sequence ID" value="CUO99206"/>
        <property type="gene ID" value="ERS852523_00167"/>
    </dbReference>
    <dbReference type="GeneID" id="66494144"/>
    <dbReference type="eggNOG" id="COG1288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018385">
        <property type="entry name" value="C4_dicarb_anaerob_car-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018387">
        <property type="entry name" value="YcgA/YfcC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43652:SF6">
        <property type="entry name" value="PTHR43652:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03606">
        <property type="entry name" value="DcuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO35723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO99206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS88862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="506" mass="53927" checksum="0183AFD343866559" modified="2016-09-07" version="1">MSKKEGKGLKSFNKGFQVPDTYIIIFLVVVVAALLTFLVPKGFYETQDISYMINGVEKTRTVIKDGSFQYLTDDAGNVVTEGVALFSGDGGTGFFNYMYNGIVSSSAIEIIAFLMVVGGAFGIMIRTGAIESGLIGLIRKAKGAEKLLIPILFVLFSLGGAVFGMGEEALPFTMILCPLFVAVGYDSVIAVLVTYVATQIGFGSSWMNPFSVGIAQGIAGIDVFSGAGFRMVMWVVFTALGCGMTMFYASKIKKTPTISIAYKTDAYFREQNEKTGIDEGHSFGLGHILVLLTLAATVVWVVWGVMTQGYYMPEIATQFFIMGIVSGVIGVIFKLNDMKLNDIATSFKDGAKDLIGAALVVAMAQGIMQVLGGSDPTTPTVINTIMYNISNALSGVSGAVAAVLMYLFQSVFNFFVVSGTGQAAITMPIMAPLSDLLGVSRQTAVVAFQLGDAFTNLIVPTSGCLIGSLAIAKIEWSNWIKFMWKFLGVLMIGAIITILIAVGIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K3D1</accession>
    <name>A0A174K3D1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="4">SDH</shortName>
            <ecNumber evidence="1 4">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroE_1</name>
        <name evidence="4 7" type="synonym">aroE</name>
        <name evidence="10" type="synonym">aroE_3</name>
        <name evidence="10" type="ORF">BWLFYP14_03120</name>
        <name evidence="7" type="ORF">ERS852478_01113</name>
        <name evidence="8" type="ORF">ERS852523_00435</name>
        <name evidence="9" type="ORF">GT712_10550</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
            <strain evidence="8 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="1 4"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP06653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000019">
        <property type="protein sequence ID" value="MZS89497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577361.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2186"/>
    <dbReference type="EnsemblBacteria" id="CUN80628">
        <property type="protein sequence ID" value="CUN80628"/>
        <property type="gene ID" value="ERS852478_01113"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06653">
        <property type="protein sequence ID" value="CUP06653"/>
        <property type="gene ID" value="ERS852523_00435"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="5">
        <location>
            <begin position="13"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="SDH_C" evidence="6">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate binding" evidence="4">
        <location>
            <begin position="21"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="132"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN80628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP06653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX66844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="290" mass="31599" checksum="B821F18F4DCD2DE3" modified="2016-09-07" version="1">MNNITGHTGLTALLGSPVAHSISPLMHNESFRLLGLDYVYLCFDVNEETLPAAVAGLKTCGIRGFNLTMPNKNKIVELLDELSPEAQLIGAVNTVLNDNGKLIGYNTDGYGFMQSVRDAGHDITGKNITVMGVGGASMAICAQSALDGAASVHIFARRTSRYWNRTQKFAENLSAKTGCQVCLFDNDDHTALRDSIAQSYLLINATSVGMVPDIDDTIIKDTSLFHPELVVADVVYEPQETRLLREAKAAGCQTFNGMYMLLHQGAKAFQIWTGQEMPVSVIKEKYFSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K7S7</accession>
    <name>A0A174K7S7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 13" type="primary">recA</name>
        <name evidence="16" type="ORF">BWLFYP14_03060</name>
        <name evidence="12" type="ORF">ERS852478_01174</name>
        <name evidence="13" type="ORF">ERS852523_00495</name>
        <name evidence="15" type="ORF">GT712_03635</name>
        <name evidence="14" type="ORF">GT728_00320</name>
    </gene>
    <organism evidence="13 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 17">2789STDY5834863</strain>
            <strain evidence="13 18">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="14 20 21" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 21">BIOML-A1</strain>
            <strain evidence="15 20">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="16 19" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP08213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381059.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2128"/>
    <dbReference type="EnsemblBacteria" id="CUN82700">
        <property type="protein sequence ID" value="CUN82700"/>
        <property type="gene ID" value="ERS852478_01174"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08213">
        <property type="protein sequence ID" value="CUP08213"/>
        <property type="gene ID" value="ERS852523_00495"/>
    </dbReference>
    <dbReference type="GeneID" id="66494010"/>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="10">
        <location>
            <begin position="37"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="11">
        <location>
            <begin position="201"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN82700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUP08213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZL31677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZS88204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VUX66784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="354" mass="38142" checksum="1AE74B31603CFF14" modified="2016-09-07" version="1">MINEEKQKALEAALGQIEKHYGKGSVMKLGESGANMQVETVPTGSLSLDIALGVGGVPKGRIIEIYGPESSGKTTVALHMVAEVQKRGGIAGFIDAEHALDPVYAKNIGVDIDNLYISQPDNGEQALEITETMVRSGAVDIVIVDSVAALVPKAEIDGDMGDSHVGLQARLMSQALRKLTAVISKSNCVVIFINQLREKVGVMFGNPETTTGGRALKFYSSIRMDVRRVETLKQGGEMVGNHTRIKVVKNKVAPPFKQAEFDIMFGTGISKEGDILDLAAECGIVNKSGAWYAYNGDKIGQGRENAKIFLKEHTDICDEIEKQVRIHYHLLPDEEGQAKEPVPATGDAPDASEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K8N3</accession>
    <name>A0A174K8N3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bacterial SH3 domain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Bacterial SH3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_02728</name>
        <name evidence="4" type="ORF">ERS852478_00232</name>
        <name evidence="5" type="ORF">ERS852523_00411</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
            <strain evidence="5 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN47241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000003">
        <property type="protein sequence ID" value="CUP05630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000017_gene253"/>
    <dbReference type="EnsemblBacteria" id="CUN47241">
        <property type="protein sequence ID" value="CUN47241"/>
        <property type="gene ID" value="ERS852478_00232"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05630">
        <property type="protein sequence ID" value="CUP05630"/>
        <property type="gene ID" value="ERS852523_00411"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4991">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="241"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN47241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP05630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="301" mass="32827" checksum="BE861BBED6452B7C" modified="2016-09-07" version="1">MDDFREWLSDNLRYFMLGGAILIIVVVLFCGIRACSGSNKGNSGDEQKTTSEDQGNVPSSPISEGESDEKKEDANPMETADADVTALITSYYQALGEKDIATLKTLEDDFTPSDESKVTNLKDYIEGYEVGDVYTKKGMTDDSYVVYACFSYICQGVETKAPALTQFYVYKNSEGNWVINNGALQDSEISAYMEKQLSDSDVSALIKKVQNELDQAQQSDPSLEEFLNGLGEEAGVSTEAEDGTMLTASEECNVRAEASTDADILGVISAGDQVQKTGTDGEWVQIDYDGQTGYIRGDLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LR37</accession>
    <name>A0A174LR37_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01419</name>
        <name evidence="2" type="ORF">ERS852523_00999</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP24488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055149948.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93497">
        <property type="protein sequence ID" value="CUN93497"/>
        <property type="gene ID" value="ERS852478_01419"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP24488">
        <property type="protein sequence ID" value="CUP24488"/>
        <property type="gene ID" value="ERS852523_00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN93497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP24488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="183" mass="20838" checksum="067096947A8833C4" modified="2016-09-07" version="1">MTRAETTKFLGQLLISTRFNGAGKHWASEVSIDPWGRDAKRVDYMQFSPADQCSISGIEKGIFTCYEVKSCKEDVYSGNGLNFLGEKNYIVTTMECYKDILPDFRSGKLAKHMRDQFPESSNYFGVMVAIPYWAEITDEFENPTPIDGNTERSWKLAAILSCRQGPRKRSMSELLFCMLRSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LTL6</accession>
    <name>A0A174LTL6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02446</name>
        <name evidence="2" type="ORF">ERS852523_01056</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO31366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP25997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000051_gene813"/>
    <dbReference type="EnsemblBacteria" id="CUO31366">
        <property type="protein sequence ID" value="CUO31366"/>
        <property type="gene ID" value="ERS852478_02446"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP25997">
        <property type="protein sequence ID" value="CUP25997"/>
        <property type="gene ID" value="ERS852523_01056"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO31366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP25997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="132" mass="15240" checksum="01DD7808E0384D08" modified="2016-09-07" version="1">MLRRYELTDEEWLRIEPLLPPENTGKQGRPRKDNRIIMNGIVWLARSGAPWRDLPERYGSWKTVYSRFRKWIDDGILDNIFRILSLEAELEELSIDASIIQAHQHSAGAKKGGLQMKSGIAVEEPAPKSMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LW74</accession>
    <name>A0A174LW74_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">atpH_1</name>
        <name evidence="6 9" type="synonym">atpH</name>
        <name evidence="10" type="ORF">BWLFYP14_01287</name>
        <name evidence="7" type="ORF">ERS852478_00914</name>
        <name evidence="8" type="ORF">ERS852523_01117</name>
        <name evidence="9" type="ORF">GT728_01255</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
            <strain evidence="8 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000009">
        <property type="protein sequence ID" value="CUP28333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380458.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000124_gene3950"/>
    <dbReference type="EnsemblBacteria" id="CUN73007">
        <property type="protein sequence ID" value="CUN73007"/>
        <property type="gene ID" value="ERS852478_00914"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP28333">
        <property type="protein sequence ID" value="CUP28333"/>
        <property type="gene ID" value="ERS852523_01117"/>
    </dbReference>
    <dbReference type="GeneID" id="66493030"/>
    <dbReference type="eggNOG" id="COG0712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN73007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP28333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL31859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX64207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="167" mass="19460" checksum="DDAA02E743EF8949" modified="2016-09-07" version="1">MTETSINYAKALYELSVPEEAVLETEKIFRSTPQLKGALENPLVSLKEKEHVIDRVFPQEMKNFLKVTCKYQKISSIYDILEAYGNYSRKQKGILKAVLTYVTKPEEAQKEKMEDFLRREFGAKEVILTLREDKSLIGGFILSAGDKEFDWSLRGRYNNLRQKLTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174N101</accession>
    <name>A0A174N101_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Glutathione transport system permease protein gsiD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gsiD_2</name>
        <name evidence="7" type="synonym">gsiD_4</name>
        <name evidence="7" type="ORF">ERS852478_02953</name>
        <name evidence="8" type="ORF">ERS852523_01498</name>
        <name evidence="9" type="ORF">GT712_01860</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
            <strain evidence="8 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP40080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993648.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000028_gene210"/>
    <dbReference type="EnsemblBacteria" id="CUO48164">
        <property type="protein sequence ID" value="CUO48164"/>
        <property type="gene ID" value="ERS852478_02953"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP40080">
        <property type="protein sequence ID" value="CUP40080"/>
        <property type="gene ID" value="ERS852523_01498"/>
    </dbReference>
    <dbReference type="GeneID" id="66493654"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO48164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP40080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS87869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="299" mass="32187" checksum="CE598BA1C3513C08" modified="2016-09-07" version="1">MADKNTTSNINLAAAEELPKAQSKFKEFVKKFMKRKTAVISLAFIVFIILMAIIGPYVVPYDPQAPDYTAMMQGPSAAHIWGTNEYGQDVFSRLMVGTRLSLTCALTATIIGTAIGVVLGLIAGFYGGIIDSLIMRCCDVLFAFPDILLAIAVVAIIGQGMVNVMIAVAVFTVPSFARIIRSATISVKQAPYVEVARSLGCSNTRILFVHIFPGTIQSMIVNFTMRVGTAILAASSLSFLGFGANVTEPDWGSMLSTGRNYLNTAPHMVLFPGILIFLTVLAFNLLGDGLRDTLDPKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NDF4</accession>
    <name>A0A174NDF4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">recF_1</name>
        <name evidence="7 10" type="synonym">recF</name>
        <name evidence="14" type="ORF">BWLFYP14_02852</name>
        <name evidence="10" type="ORF">ERS852478_02191</name>
        <name evidence="11" type="ORF">ERS852523_01707</name>
        <name evidence="13" type="ORF">GT712_11365</name>
        <name evidence="12" type="ORF">GT728_11205</name>
    </gene>
    <organism evidence="11 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">2789STDY5834863</strain>
            <strain evidence="11 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 19">BIOML-A1</strain>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the RecF family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000015">
        <property type="protein sequence ID" value="CUP46702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000025">
        <property type="protein sequence ID" value="MZL33749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708000.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000021_gene1699"/>
    <dbReference type="EnsemblBacteria" id="CUO22384">
        <property type="protein sequence ID" value="CUO22384"/>
        <property type="gene ID" value="ERS852478_02191"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP46702">
        <property type="protein sequence ID" value="CUP46702"/>
        <property type="gene ID" value="ERS852523_01707"/>
    </dbReference>
    <dbReference type="GeneID" id="66493383"/>
    <dbReference type="eggNOG" id="COG1195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="9">
        <location>
            <begin position="2"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO22384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP46702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL33749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS89654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX66477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="361" mass="41240" checksum="797BEBFAE544B4CE" modified="2016-09-07" version="1">MYIESVQLKNFRNYDSLELDLAQGTNIFYGNNAQGKTNILEALYLCGTTKSHKGSRDKDMIQFGKDESHIRMMVKRDELSYRIDMHLKKNKAKGVAINGLPIRKASELFGVVNLVFFSPEDLNIIKNGPGERRRFLDLELCQLDKIYLTDLASYNHIVNQRNKLLKDLSVQPSLKDTLDIWDIQMAEYGRKIIDKRSEFIKELNETVRKIHGNLTGGLEELNVIYEPDCTAEKLESTICANRERDMRMRLTSAGPHRDDLCVMANGIDIRKYGSQGQQRTAALSLKLSEIYIVKRKIKDTPVLLLDDVLSELDSSRQNYLLDSISDIQTLITCTGLDDFISHQFQINKVFQVVQGTVSQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NDG3</accession>
    <name>A0A174NDG3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Propanediol utilization protein PduA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pduA_2</name>
        <name evidence="4" type="synonym">pduA_1</name>
        <name evidence="6" type="ORF">BWLFYP14_01561</name>
        <name evidence="4" type="ORF">ERS852478_02315</name>
        <name evidence="5" type="ORF">ERS852523_01626</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
            <strain evidence="5 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP44059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000086_gene4008"/>
    <dbReference type="EnsemblBacteria" id="CUO26716">
        <property type="protein sequence ID" value="CUO26716"/>
        <property type="gene ID" value="ERS852478_02315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP44059">
        <property type="protein sequence ID" value="CUP44059"/>
        <property type="gene ID" value="ERS852523_01626"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020808">
        <property type="entry name" value="Bact_microcomp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01139">
        <property type="entry name" value="BMC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="3">
        <location>
            <begin position="71"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO26716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP44059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX64707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="158" mass="16612" checksum="84D2AC3B62C7B888" modified="2016-09-07" version="1">MAEEKKPEADKNAPKKAAAPRRTKAKTSSKPEVKAQTADTAAETANKTESQKEQIKETVSHKEEKVMTQEALGMVETRGLTAAIEAADQMCKAANVALVGTEKIGSGLVTVMVRGDVGAVKSAVESGSAAASRLGELVATHVIPRPHTDVEKILPVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174PZY9</accession>
    <name>A0A174PZY9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_00942</name>
        <name evidence="2" type="ORF">ERS852478_02683</name>
        <name evidence="3" type="ORF">ERS852523_02266</name>
        <name evidence="5" type="ORF">GT712_04740</name>
        <name evidence="4" type="ORF">GT728_17825</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO39474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000023">
        <property type="protein sequence ID" value="CUP63399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000063">
        <property type="protein sequence ID" value="MZL34981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000007">
        <property type="protein sequence ID" value="MZS88411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993336.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39474">
        <property type="protein sequence ID" value="CUO39474"/>
        <property type="gene ID" value="ERS852478_02683"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP63399">
        <property type="protein sequence ID" value="CUP63399"/>
        <property type="gene ID" value="ERS852523_02266"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO39474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP63399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX63463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="81" mass="9720" checksum="BBB06E8DD77C650C" modified="2016-09-07" version="1">MKSPLKNLKKYFQLIMTALICFVMGVIEDKKRICIKDTDSKKDRTVLRPDDKKNNRKNKIIYWNEPRIQNRINRAVYFNTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174RT54</accession>
    <name>A0A174RT54_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 17" type="primary">rpoB</name>
        <name evidence="20" type="ORF">BWLFYP14_03381</name>
        <name evidence="16" type="ORF">ERS852478_02934</name>
        <name evidence="17" type="ORF">ERS852523_03109</name>
        <name evidence="19" type="ORF">GT712_01100</name>
        <name evidence="18" type="ORF">GT728_08610</name>
    </gene>
    <organism evidence="17 22">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 21 22" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 21">2789STDY5834863</strain>
            <strain evidence="17 22">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="18 24 25" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 25">BIOML-A1</strain>
            <strain evidence="19 24">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="20 23" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000039">
        <property type="protein sequence ID" value="CUP87221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000016">
        <property type="protein sequence ID" value="MZL33256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705171.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000068_gene3399"/>
    <dbReference type="EnsemblBacteria" id="CUO47400">
        <property type="protein sequence ID" value="CUO47400"/>
        <property type="gene ID" value="ERS852478_02934"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP87221">
        <property type="protein sequence ID" value="CUP87221"/>
        <property type="gene ID" value="ERS852523_03109"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="13">
        <location>
            <begin position="31"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="12">
        <location>
            <begin position="144"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="12">
        <location>
            <begin position="402"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="14">
        <location>
            <begin position="496"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="15">
        <location>
            <begin position="574"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="10">
        <location>
            <begin position="705"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="11">
        <location>
            <begin position="1134"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1236"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1236"/>
            <end position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUO47400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUP87221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MZL33256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MZS87721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VUX67104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="1286" mass="145352" checksum="134C463F08C41E1A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174S4R0</accession>
    <name>A0A174S4R0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_03535</name>
        <name evidence="1" type="ORF">ERS852478_03020</name>
        <name evidence="2" type="ORF">ERS852523_03224</name>
        <name evidence="4" type="ORF">GT712_01480</name>
        <name evidence="3" type="ORF">GT728_10165</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000042">
        <property type="protein sequence ID" value="CUP90638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000021">
        <property type="protein sequence ID" value="MZL33553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50399">
        <property type="protein sequence ID" value="CUO50399"/>
        <property type="gene ID" value="ERS852478_03020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP90638">
        <property type="protein sequence ID" value="CUP90638"/>
        <property type="gene ID" value="ERS852523_03224"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZQ5H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO50399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP90638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS87795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX67260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="48" mass="5353" checksum="A0D8FE33BF2B669F" modified="2016-09-07" version="1">MSMFIHAIIVILLAVLAMGIGLLILVCWALAACASRRDSYLEKDYRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174S7S6</accession>
    <name>A0A174S7S6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inner membrane ABC transporter permease protein yjfF</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Sugar ABC transporter permease YjfF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yjfF</name>
        <name evidence="7" type="ORF">ERS852478_03014</name>
        <name evidence="8" type="ORF">ERS852523_03218</name>
        <name evidence="9" type="ORF">GT728_10135</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
            <strain evidence="8 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000042">
        <property type="protein sequence ID" value="CUP90479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000021">
        <property type="protein sequence ID" value="MZL33547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705029.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000010_gene2796"/>
    <dbReference type="EnsemblBacteria" id="CUO50248">
        <property type="protein sequence ID" value="CUO50248"/>
        <property type="gene ID" value="ERS852478_03014"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP90479">
        <property type="protein sequence ID" value="CUP90479"/>
        <property type="gene ID" value="ERS852523_03218"/>
    </dbReference>
    <dbReference type="GeneID" id="66495452"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO50248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP90479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="340" mass="36243" checksum="386C052D4CE491D9" modified="2016-09-07" version="1">MKANVQKKKITGNGFLLLITIALFVVMYVAGMIVFADKGFAKPQMFLNLFVSNAGLLVIACGLTIVMITGGIDISVGSVTALVCMVLADLMENKGVNAYAAVLVALLIGVAFGIVQGFLVAYLDIQPFIVTLAGMFFGRGLTAIISTDMISIKNELFLKWANYRFYMPFGSTSKKGKFIPAYIPPTVVIALIVVILIAVLLKYRKFGRKLYAIGGSRQSALMMGLNVKKTIFNAYVLDGFLAGLGGFLFCLNSCAGFVEQAKGLEMDAISSAVIGGTLLSGGVGTPIGTLFGVLIKGTISSLITTQGTLSSWWTRIILSALLCFFIVIQSVVASMKKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WW74</accession>
    <name>A0A173WW74_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="6">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">nadD</name>
        <name evidence="8" type="ORF">ERS852478_00102</name>
        <name evidence="9" type="ORF">GT712_00955</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381239.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43772">
        <property type="protein sequence ID" value="CUN43772"/>
        <property type="gene ID" value="ERS852478_00102"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="7">
        <location>
            <begin position="10"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN43772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS87693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="211" mass="24784" checksum="D2EDE1D3F06D39B1" modified="2016-09-07" version="1">MADIKHRIGIMGGTFDPIHMGHLILGEKAYEQFRLEKVLFMPSGNPPHKRNRQGRATDEERVEMVRRAITGNPHFELSLTEMHENGYTYTYHTLEMLKEKNPDTDYYFIIGADSLYDFDTWREPERICRNCILVTAVRNHSTIAELEAEMNRLSLKYNGTFLTLNTTNLDVSSEMLRNWIREDKSVRYYIPDPVIEYIRENQIYSLAEKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WYH9</accession>
    <name>A0A173WYH9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">D-alanyl-D-alanine carboxypeptidase dacB</fullName>
            <ecNumber evidence="12">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dacB_1</name>
        <name evidence="12" type="ORF">ERS852478_00129</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="12"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44523">
        <property type="protein sequence ID" value="CUN44523"/>
        <property type="gene ID" value="ERS852478_00129"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="11">
        <location>
            <begin position="157"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN44523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="399" mass="43832" checksum="AD6ECAE6448A9CDA" modified="2016-09-07" version="1">MRTKKKSSGKIPEKKSAVPYKSTAPHRHKPSRPLQTVKLPKSQMPSRQTEEHQALLRTKYHKKRQRLKHIFRILVGVFVILAAAGGVFYGWNILSGNYFGTPEQAFDSSEVFTNALAAKENMRTESFAQKLCVSPKGNVDRIKNAQLEDGQKGLLFSLSNHKVLYANGIYDKVYPASITKIMTAMLALQSGKLNDTVTITQDNVTLEDGSQVCGFVAGDQVTLDQLLHCLLVYSGNDAASAIAEYVGGNTENFVQMMNDYAAKLGCTGTHFSNPHGLQDENHYTTPYDIYLMLNEAFTYPEFTEITELPSYTVTYTGSDGTEKSTTLTATDHYLTGEATAPKDVTILGGKTGTTEVAGNCLAILTQNAYGKTFVSIVMGAATKELLYQEMNSLLQNINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WZR3</accession>
    <name>A0A173WZR3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02647</name>
        <name evidence="2" type="ORF">ERS852478_00149</name>
        <name evidence="3" type="ORF">GT712_00710</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993917.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44991">
        <property type="protein sequence ID" value="CUN44991"/>
        <property type="gene ID" value="ERS852478_00149"/>
    </dbReference>
    <dbReference type="GeneID" id="66495874"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN44991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS87647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="114" mass="13057" checksum="BD5FF4ABD4B0FAE9" modified="2016-09-07" version="1">MYDTEKRIELVKKRMHEYHRRQERRTVCRLSVLCTLLFLSLVGTMGMMQSQPIDITGMYGTILLHEDAGGYVLVAVISFTVAVVITALCIKFRKRGQKSQDVEDHVLKKGKVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X5T2</accession>
    <name>A0A173X5T2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="20" type="ORF">ERS852478_00203</name>
        <name evidence="22" type="ORF">GT712_00445</name>
        <name evidence="21" type="ORF">GT728_05980</name>
    </gene>
    <organism evidence="20 23">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="20 23" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 23">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="21 24 25" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 25">BIOML-A1</strain>
            <strain evidence="22 24">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703284.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46446">
        <property type="protein sequence ID" value="CUN46446"/>
        <property type="gene ID" value="ERS852478_00203"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CUN46446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="MZL32766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="MZS87596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="258" mass="28408" checksum="6CAE1E873AD086A6" modified="2016-09-07" version="1">MKSLWNNFKVAFAMFSKIPMPRADWTKENMKYMFCFFPFIGTVIGGLTMLVAYLGLRFGYQPGFVTAVLVLVPVFVTGGIHVDGLLDTSDALSSWQERSRRLEILKDSHAGAFAVITAAVYFIAWYGAYSQLFNSAENMRAIGILSLGFMVSRCLSGIGVITFPKAKADGTVAEFSRNSSDVLSRNVLIVYLVLLAAGMILIRPVWGSLAFVGALLIFWYYHHIAMKYFGGTTGDISGFFLCICEVGMALILAVVSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XAK3</accession>
    <name>A0A173XAK3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN48819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199524.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN48819">
        <property type="protein sequence ID" value="CUN48819"/>
        <property type="gene ID" value="ERS852478_00249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN48819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="235" mass="26303" checksum="EDDACCE863676A64" modified="2016-09-07" version="1">MAQKYDLTDIGNALSRVMDNPMTKIIRSGSIGVLGVVNPVAGIVGGIGNDLLSEYNTFKLGHLLNGLASGFNLERRLNELYNYVNSSPEKAIIVANLFKQTVNAECPKVCVIYGLILANHLETLTEFTHEELIVCKALENATDYDLKNFKEIMENYLKPTSNGRRIVFPKDFADIAAFTTTCDWCVYNRIFVSRTAEWGEMEEGVLDMSTYYYEANPASVLLDNINAARQTWNYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XAY0</accession>
    <name>A0A173XAY0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MATE family efflux transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Multidrug-efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mdtK_1</name>
        <name evidence="2" type="ORF">ERS852478_00243</name>
        <name evidence="3" type="ORF">GT712_00245</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN47548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN47548">
        <property type="protein sequence ID" value="CUN47548"/>
        <property type="gene ID" value="ERS852478_00243"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN47548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS87558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="460" mass="50160" checksum="B4A292DF9CAF4BFC" modified="2016-09-07" version="1">MINTLSAGKDNFYRQMLKLTIPIIIQNLLSAAVNSADVIMLNYVGQSAISAVSLAANYSNILFMVYYGLGTGASLLCAQYFGKNNMQAIHAIEGIALRFSIIISGIVALIAFTAPQLMMKIFTSDQELISIGSSYLRIMGITYLCWGITEIYLAILRSIGRVTISMALNMLAFILNIILNATFIFGLFGAPKLGATGVAIATAASRLIELAACVIVSFLSKDVKLNLTFMFIRSKVLFGDFVRLSLPALGNDISWSVAFSMYSVILGHLGTDAVAANSLVTVVRNIGSVFCFAIASAGTILLGNVMGKGDLEKSKVYASRMLKMTIIAGAIGGVIVFAITPLVLRFASLNDGAMHYLKYMLLINTYYIMGSAVNTALIAGVFRAGGDTKFGLICDTIDMWVYAVPLGFFAAFVLKLPVLWVYFLLCTDEFVKWPWVFHHYRQGKWAQNITREDLFEQKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XBL3</accession>
    <name>A0A173XBL3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993600.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49043">
        <property type="protein sequence ID" value="CUN49043"/>
        <property type="gene ID" value="ERS852478_00257"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN49043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="80" mass="9075" checksum="77360B620BD20B9D" modified="2016-09-07" version="1">MDITSAETKATYDEIKKYVAEHNAGMKVSNLYISQVKRKCGIEVGKNYNLPKNEDSRQPQCPEDKESAIVEAVKHCKMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XD63</accession>
    <name>A0A173XD63_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Diflavin flavoprotein A 1</fullName>
            <ecNumber evidence="8">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dfa1</name>
        <name evidence="8" type="ORF">ERS852478_00280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mediates electron transfer from NADH to oxygen, reducing it to water. This modular protein has 3 redox cofactors, in other organisms the same activity requires 2 or 3 proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the flavodoxin reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199633.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49732">
        <property type="protein sequence ID" value="CUN49732"/>
        <property type="gene ID" value="ERS852478_00280"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="6">
        <location>
            <begin position="243"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="7">
        <location>
            <begin position="559"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN49732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="596" mass="66962" checksum="32348237DD07D872" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XQS4</accession>
    <name>A0A173XQS4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Degradation activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">degA_1</name>
        <name evidence="5" type="ORF">ERS852478_00395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199600.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53286">
        <property type="protein sequence ID" value="CUN53286"/>
        <property type="gene ID" value="ERS852478_00395"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN53286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="336" mass="38531" checksum="BC44FFDD8B606B8A" modified="2016-09-07" version="1">MTQNRVRIVDVADALGLSTATVSKVIHGKTEKISDETVKRVQQELERSGYIPNMAGILLARNNSRIIGVVVNDHEKYEGRVLEDGFVMSSLNALSHEVNEKGYFLMIKTTSDIREIPVFASMWNMDGLILIGFCEADYESLRNQMRISFVVYDGYFEKCSKVVNLVIDHYNGGYQAGKYLKELGHKKALCIADNFICMDKERIEGFRKAFEPGETYRWEIPKTERERMCFYEDNYMQLPENSVTAVFAVSDFYALEFMRFLQGKNFRIPEDIQIIGFDDNMASRESNPSLTTIHQEANLRAKAAIKCLEAMRDGAEYKTEIVLPVDLIKRESTRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XW48</accession>
    <name>A0A173XW48_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199644.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56141">
        <property type="protein sequence ID" value="CUN56141"/>
        <property type="gene ID" value="ERS852478_00461"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN56141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="108" mass="12839" checksum="732C37428F7D3581" modified="2016-09-07" version="1">MKSIIQKLYNLYMEENDRTDIERLRTQGDDLCKKKREDAYQSYQKLRSRLTGNLAEELDILMDKHLEIFPQELENSFEAGFKTGAKLMCEIFSEEAETIKRYGSFRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XXQ6</accession>
    <name>A0A173XXQ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-dehydro-3-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">eda_1</name>
        <name evidence="5" type="ORF">ERS852478_00468</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:17089"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57569"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199651.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56389">
        <property type="protein sequence ID" value="CUN56389"/>
        <property type="gene ID" value="ERS852478_00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031337">
        <property type="entry name" value="KDPG/KHG_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00159">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN56389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="214" mass="23009" checksum="0559C368BFBE6123" modified="2016-09-07" version="1">MNKILKKLEQFGIVPVVVLEDDKDAALLAKALCDGGLACAEVTFRTAAAEESIRIMSEKFPEMVVGAGTVLTVEQVDRAVKAGAQFIVSPGFNPVVVKYCIDHEIPITPGVVTPSEMEQAIAMGLEVVKFFPAEPSGGLDMIKAVAAPYTTLRFMPTGGINPENIVPYLQYDKILACGGSWMVKGNLVARGDFDQITELTKEAVSLVYSAREVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y560</accession>
    <name>A0A173Y560_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sortase (Surface protein transpeptidase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58075">
        <property type="protein sequence ID" value="CUN58075"/>
        <property type="gene ID" value="ERS852478_00518"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05826">
        <property type="entry name" value="Sortase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009835">
        <property type="entry name" value="SrtB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03064">
        <property type="entry name" value="sortase_srtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN58075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="295" mass="33945" checksum="68CD32381797EAA6" modified="2016-09-07" version="1">MKKLRTFAVSMIIAAIGLLIYCAGFYIKSYEQNLAARQEYAELSQMAGVKNREGAGLLADGKKTDEDSSTKNSEKKRRKKQRRSSESKNKNCTDEIRESFGISWENLRKINSQTVAWITVPGADISYPVVQAADDEYYLKHNFRGEEDLFGCIFLEHDIKKNFTDSHSILYGHNIEGNMMFANLNRYEQPEFLKKCPEIEITTPKRKFLYKIFSVEQASSKSPAFEYGYKLSSPAYRRQLSILKNNSMYDTGVEPDERERMVTLITCNSRLDKEIRMAVHGICHECYGIEKAEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y5C5</accession>
    <name>A0A173Y5C5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted signal transduction protein with a C-terminal ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199708.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59342">
        <property type="protein sequence ID" value="CUN59342"/>
        <property type="gene ID" value="ERS852478_00562"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="3">
        <location>
            <begin position="336"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="228"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN59342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="439" mass="49920" checksum="B5CADE8DDDAEA0D5" modified="2016-09-07" version="1">MTDILCPVLELSVIIPGILLAYLPVKNYLRQTPLKLTAWLLPLLLGICILGGAVCCALQIPTRWFLFPLLPVIMLIYHKTLKISVWKSVSIFLAVFAVFTCVKSLSRAVNALMTADLHITENELWLHTGAGIFYNVICLLFVLAAWYPALHGVQTMVADENFAQTWYVFWILPVIFIGVNLFMIPKYRSTLYTGRVLQCYIVFSLVLLIILLLFYVLFLMMAVSLNRNARLQQENHFLSLQQERYENLCMAIEEARQARHDIRHHFVRLSALAEQGDIEKIKEYLSAATGKISDYNLHFCENQAVDSVFGYYSTIAERENIPFHALVSLPADLSIDEINLCLVFSNLLENAIQASVKTVPARRKINVEVYPHHNHLLLIHVENTFDGKIQQKNNIFQSSKRSGNGIGIESVRHIIDKNGGACDFTYKDGIFSAKIMLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y7Y1</accession>
    <name>A0A173Y7Y1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetylglutamate kinase</fullName>
            <ecNumber evidence="7">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">NAG kinase</fullName>
            <shortName evidence="7">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">argB</name>
        <name evidence="9" type="ORF">ERS852478_00560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053055.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59266">
        <property type="protein sequence ID" value="CUN59266"/>
        <property type="gene ID" value="ERS852478_00560"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN59266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="298" mass="32845" checksum="05325A94DD0ADFF4" modified="2016-09-07" version="1">MVNQKYLDKAEVLIEALPYIQRFNRKIVVVKYGGSAMLDDELKKNVIKDVVLLKLVGFKPIIVHGGGKEISRWVGKVGMEPKFINGLRVTDKDTMEIAEMVLAKVNKELVAMVESLGVNAVGISGKDGGLLKCRKKQTEGGDIGFVGEVTKVEPKILEDLLEKDFLPIIFPVGYDDEFATYNINADDAACAIAEAVHAEKLAFLSDIEGVYKDKDDSSSLISELHVDEAQKLIDDGYVGGGMIPKLKNCIDAIEEGVNRVHILDGRIPHSLLLEIFTNKGIGTAILREDGEKYYNEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y8B1</accession>
    <name>A0A173Y8B1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199710.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59467">
        <property type="protein sequence ID" value="CUN59467"/>
        <property type="gene ID" value="ERS852478_00566"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015994" evidence="1">
        <location>
            <begin position="29"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN59467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="688" mass="75561" checksum="0EC391ACCA00E619" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YB55</accession>
    <name>A0A173YB55_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-aspartate oxidase</fullName>
            <ecNumber evidence="4">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">nadB</name>
        <name evidence="11" type="ORF">ERS852478_00593</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053024.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPC010000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60386">
        <property type="protein sequence ID" value="CUN60386"/>
        <property type="gene ID" value="ERS852478_00593"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0029">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="10">
        <location>
            <begin position="6"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN60386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="429" mass="48488" checksum="EC9FDA4B3DC8387C" modified="2016-09-07" version="1">MKEHYDVIIVGTGAAGLYCALNLPEKMKILLITKQEADQSDSFLAQGGICMLRGEDDYENYFEDTMRAGHYENNKRAVDLMIRSSNDIIRDLLRYHVDFTRDGLGNLAFTREGAHSQPRILFHEDITGKEITQTLLTAAKIKENIEICEYMTMVDLISKDNTVCGIIAMDRNDQAFPVYSQYVVLACGGIGGLFKNSTNFSHIAGDGVGIAMKHHVEMENLDYIQIHPTTLYSKKPGRRFLVSESVRGEGALLYDKNGQRFTNELQPRDLLSQKISAQMEKDGTEFVWEDMRPLGEKTILEHFPHIYEQCVEEGFDPRKEPIPVVPAQHYFMGGIKVNLGSKTSMKGLYACGETSCNGVHGRNRLASNSLLESLVFARKAADDMIFGQTPEYVRADAIDMNMYESREELLNACHETVLKEIERMKKSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YEF1</accession>
    <name>A0A173YEF1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">EamA-like transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">arnE_2</name>
        <name evidence="5" type="ORF">BWLFYP14_03240</name>
        <name evidence="2" type="ORF">ERS852478_00616</name>
        <name evidence="3" type="ORF">ERS852523_01807</name>
        <name evidence="4" type="ORF">GT712_08520</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000016">
        <property type="protein sequence ID" value="CUP49759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000014">
        <property type="protein sequence ID" value="MZS89114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX66963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706128.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000022_gene1730"/>
    <dbReference type="EnsemblBacteria" id="CUN61168">
        <property type="protein sequence ID" value="CUN61168"/>
        <property type="gene ID" value="ERS852478_00616"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP49759">
        <property type="protein sequence ID" value="CUP49759"/>
        <property type="gene ID" value="ERS852523_01807"/>
    </dbReference>
    <dbReference type="GeneID" id="66492513"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN61168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP49759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="116" mass="13379" checksum="7E17BB822EFECEF9" modified="2016-09-07" version="1">MSKLKDYIQLHLNILLFSLTSVFSKAASVQYNKHGLSSPLLYLFLFLMVANCGIYAITWQQVIKKFSLSTAYANKSVYLLWSQIWAVLIFHENLSIQNIIGILVVLFGVWTVQRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YJA6</accession>
    <name>A0A173YJA6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Beta-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Lactase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lacZ</name>
        <name evidence="10" type="ORF">ERS852478_00676</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 8"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199755.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64222">
        <property type="protein sequence ID" value="CUN64222"/>
        <property type="gene ID" value="ERS852478_00676"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023232">
        <property type="entry name" value="Glyco_hydro_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023230">
        <property type="entry name" value="Glyco_hydro_2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00719">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00608">
        <property type="entry name" value="GLYCOSYL_HYDROL_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bgal_small_N" evidence="9">
        <location>
            <begin position="776"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN64222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1060" mass="121759" checksum="143394C4F770A051" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YWZ5</accession>
    <name>A0A173YWZ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted metal-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058123.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67485">
        <property type="protein sequence ID" value="CUN67485"/>
        <property type="gene ID" value="ERS852478_00767"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3872">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010787">
        <property type="entry name" value="DUF1385"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07136">
        <property type="entry name" value="DUF1385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN67485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="322" mass="36235" checksum="577E538279EFE4DB" modified="2016-09-07" version="1">MKSSNIGGQAVMEGIMMRHKDKYSIAVRRPDNEIELKVEDYKCVFGNAKFLKYPLIRGVVSFVDSLVVGTKCLMYSAEIAGDEEDEEDKQKNAALSEEELAAKKAKEDKQFKWLLYVTVAVSIVVSVAAFMLLPYALASLCRRGGASEFAVTIVEAFVKLALFMGYMLLISRMKDIQRTFMYHGAEHKCINCVEHGLPLTVDNVLASSRLHKRCGTSFLFLVMLVSIFLHFIFVLVPFYWVRLFGRLLMVPVVAGISFEIIQWAGRSDSKLADFFSKPGLAMQKLTTKEPTADMAEVAIRAVEAVFDWKAYLKEEFGVEAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z7T4</accession>
    <name>A0A173Z7T4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glgC_1</name>
        <name evidence="7" type="ORF">ERS852478_00864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026648773.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71536">
        <property type="protein sequence ID" value="CUN71536"/>
        <property type="gene ID" value="ERS852478_00864"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011832">
        <property type="entry name" value="GlgDAde_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02092">
        <property type="entry name" value="glgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN71536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="372" mass="42551" checksum="CF975EA53E454E7C" modified="2016-09-07" version="1">MRAIGIILAGGNNNRMRELSNKRAIAAMPIAGSYRSIDFALSNMASSHIQRVAVLTQYNARSLNEHLSSSKWWDFGRKQGGLFVFTPTITKENSLWYQGTADAIYQNLEFLKSSHEPYVVIASGDCVYKMDYNKVLEYHIAKRADVTVVCTTCDDPSEIERFGVLRMNEDCRIEEFEEKPMVSSYNTISTGIYVIRRRQLIELIERAALEGRHDFVKDILIRYKNLKRIYGYKIDTYWSNISTAEAYYKTNMDFLKPEIRNYFFKQEPTIKTKIDDLPPAKYNPGAQVKNSLVASGCIINGTVENSVLFKDVFVGNNCVIKNSVILNNVYLGDNTHIENCIVESRDTIRANSYYCGDGEVKIVVEKNDRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z9P7</accession>
    <name>A0A173Z9P7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72637">
        <property type="protein sequence ID" value="CUN72637"/>
        <property type="gene ID" value="ERS852478_00902"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN72637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="183" mass="20557" checksum="EDFA2B256A39B25F" modified="2016-09-07" version="1">MLDKGCTTIKGALNELDAAGLLERRRMGFSAANRLYVKVPPIPVVQFSDQLTDKKPTLIRAGNRPTDSRKTDLMTDGKPSPNQTNINNLIESQTKRASEGQPPAAYGRYKNVFLSDAELMELEQDFPGKWEYYLDRLSCHIASTGKQYQNHAATIYKWAQEDAAKEKPKKGIPDYSFKEGESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZB48</accession>
    <name>A0A173ZB48_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV secretion system protein virB11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199838.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72405">
        <property type="protein sequence ID" value="CUN72405"/>
        <property type="gene ID" value="ERS852478_00895"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4962">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="68"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN72405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="396" mass="44684" checksum="823A0AD840069095" modified="2016-09-07" version="1">MNKDVFRKLRQMLMEELDLSRELSDKEILDVIDELILNQIKDVRLALKEKVQLRQELFYSVRKLDVLQELVDDETVTEIMVNGPDTIFVERAGKLMKWHKSFTSAEKLEDVIQQIVGKCNRVINESMPIVDARLENGSRVNAVIYPVALNGPILTIRRFPEHPITMEKLIALGSITQECAEFLEKLVKARYSMVIGGGTGSGKTTFLAAMSEYIPKDERLITIEDNAELRIRGIDNLVRLEAKMANMEGAVSVTIRDLIKSALRMRPDRIIVGEVRGGEAMDMLQALNTGHEGSLSTAHANSARDMLSRLETMVLMGVDLPLEAIRRQIASGVDILVHLGRMRDKSRKLLEVTEVCGFENGEIRIRPLYQWQEGKGLVKTASLLHVEKLERAGIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZDE4</accession>
    <name>A0A173ZDE4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease III</fullName>
            <ecNumber evidence="1">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pdg</name>
        <name evidence="1" type="synonym">nth</name>
        <name evidence="6" type="ORF">BWLFYP14_01320</name>
        <name evidence="3" type="ORF">ERS852478_00949</name>
        <name evidence="4" type="ORF">ERS852523_01177</name>
        <name evidence="5" type="ORF">GT712_09565</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
            <strain evidence="4 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000009">
        <property type="protein sequence ID" value="CUP29967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579857.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000054_gene1870"/>
    <dbReference type="EnsemblBacteria" id="CUN74067">
        <property type="protein sequence ID" value="CUN74067"/>
        <property type="gene ID" value="ERS852478_00949"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP29967">
        <property type="protein sequence ID" value="CUP29967"/>
        <property type="gene ID" value="ERS852523_01177"/>
    </dbReference>
    <dbReference type="GeneID" id="66493064"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="2">
        <location>
            <begin position="39"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN74067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP29967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX64273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="215" mass="23952" checksum="990E83A268DC20D3" modified="2016-09-07" version="1">MTKQELALEVIERLKKEYPDADCTLDYDNAWKLLVSVRLAAQCTDARVNVVVQDLYAKFPTVEALANADVADIEAIVRPCGLGKSKARDISACMKILHEQYHDNVPGDFDALLKLPGVGRKSANLIMGDVFGKPAIVTDTHCIRLSNRIGLVDNMKEPKKVEMALWKIIPPEEGNDLCHRLVNHGRDVCTARTKPYCDRCCLNDICEKNGVDSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZG91</accession>
    <name>A0A173ZG91_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Beta-glucoside kinase</fullName>
            <ecNumber evidence="1">2.7.1.85</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bglK</name>
        <name evidence="1" type="ORF">ERS852478_00971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.85" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199859.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74689">
        <property type="protein sequence ID" value="CUN74689"/>
        <property type="gene ID" value="ERS852478_00971"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047700">
        <property type="term" value="F:beta-glucoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN74689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="292" mass="31226" checksum="982A7188C49478BA" modified="2016-09-07" version="1">MKILVFDIGGTAIKYGICQDGHLMETSECPTEAYKGGPHILETICTLAEQSLPFDAIGISTAGQVNPEEGYIIYANSNIPDYTGTQFQKILQERFHVPVAVENDVNSAALGEAIFGAGKGKDSFLCLTYGTGVGGAIIENKQVYHGSSFSAGEFGAIITHAEEKLAGTDPFDGCYERYASATALVKMVSAVDPSLTNGRQIFANLERPEIKAVVNKWIDEIVLGLATLIHIFNPSCVVLGGGIMVQPYILEQIHARIPQMVMSSFAHVQISSAELGNSAGLLGAYYLASQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZMK0</accession>
    <name>A0A173ZMK0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76889">
        <property type="protein sequence ID" value="CUN76889"/>
        <property type="gene ID" value="ERS852478_01038"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018695">
        <property type="entry name" value="DUF2194"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09960">
        <property type="entry name" value="DUF2194"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN76889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="612" mass="69498" checksum="E77A8627A2A82A56" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZU49</accession>
    <name>A0A173ZU49_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">hrcA</name>
        <name evidence="8" type="ORF">ERS852478_01061</name>
        <name evidence="9" type="ORF">ERS852523_02676</name>
        <name evidence="10" type="ORF">GT728_14310</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
            <strain evidence="9 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000030">
        <property type="protein sequence ID" value="CUP75010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000037">
        <property type="protein sequence ID" value="MZL34340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707388.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000035_gene3847"/>
    <dbReference type="EnsemblBacteria" id="CUN78745">
        <property type="protein sequence ID" value="CUN78745"/>
        <property type="gene ID" value="ERS852478_01061"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP75010">
        <property type="protein sequence ID" value="CUP75010"/>
        <property type="gene ID" value="ERS852523_02676"/>
    </dbReference>
    <dbReference type="GeneID" id="66496214"/>
    <dbReference type="eggNOG" id="COG1420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005104">
        <property type="entry name" value="WHTH_HrcA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03444">
        <property type="entry name" value="HrcA_DNA-bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HrcA_DNA-bdg" evidence="7">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="104"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN78745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP75010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL34340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="346" mass="38491" checksum="0F57B357E2F383EE" modified="2016-09-07" version="1">MDQELDDRKKKILKAIIKTYMETGEPVGSRTISKFADLNVSSATIRNEMSDLTDMGYIVQPHTSAGRIPSDKGYRLYVDELMKEKESEVQEIKDLMIEKTDKLDKMLKQVAKVLASNTNYATMISVPQYSGSKIKFIQLSRVTPLQLVAVVVSDNNVIRNQIINLDEEMDDQTILKLNLLLNTNLNGVPIQDINLGMIARLKEQAGVHGSVVGTVLDAVADTIQVDEDDMQIYTSGATNIFKYPELADTSKASELISAFEEKQDLVDLVKERMSDTENTGIQVYIGDEMPVQTMKDCSVVTATYELGKGMHGTIGIIGPKRMDYANVVDSLKALKVQLDELIKKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A0H6</accession>
    <name>A0A174A0H6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in cyanobacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199929.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80908">
        <property type="protein sequence ID" value="CUN80908"/>
        <property type="gene ID" value="ERS852478_01121"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN80908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="180" mass="20459" checksum="3B99A6B0EC2C5875" modified="2016-09-07" version="1">MPLPKERIYTIDDIYALPDGERAELIDGQIYMMAPPNTRHQVIVGELYATIRNYIKSKDGSCKPYVSPFAVFLNEDNKNYVEPDLTVVCSPDKVDEKGCHGAPDWVIEVVSPATQSKDYGIKLFKYRMSGVREYWIINPMKGIVNVYDFENESGTGLYSFDDEILVCIYPDLSIVISELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AC67</accession>
    <name>A0A174AC67_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CHAP domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006857254.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86007">
        <property type="protein sequence ID" value="CUN86007"/>
        <property type="gene ID" value="ERS852478_01234"/>
    </dbReference>
    <dbReference type="GeneID" id="61431736"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="3">
        <location>
            <begin position="481"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN86007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="591" mass="63595" checksum="59118B44E8B1445E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AGR3</accession>
    <name>A0A174AGR3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577652.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000138.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87099">
        <property type="protein sequence ID" value="CUN87099"/>
        <property type="gene ID" value="ERS852478_01264"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50330G9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN87099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="68" mass="7196" checksum="68A5547C80E6DE76" modified="2016-09-07" version="1">MAVNQKAVKVLNKVLEAGFTDEKAIAAMTMDDILSMQGITVGDITLINDLQKSIKSNKVISFLGGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AQI0</accession>
    <name>A0A174AQI0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitric oxide reductase</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fprA</name>
        <name evidence="3" type="ORF">ERS852478_01364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200034.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90493">
        <property type="protein sequence ID" value="CUN90493"/>
        <property type="gene ID" value="ERS852478_01364"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016440">
        <property type="entry name" value="Rubredoxin-O_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005243">
        <property type="entry name" value="ROO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="244"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN90493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="385" mass="43386" checksum="8E7EB08DD40681FA" modified="2016-09-07" version="1">MKIGNDIYYVGVNDHQVDLFEGQYVVPNGMSYNSYVIMDEKIAVMDTVDANFKDEWLENVARVLDGAKPDYLVVQHMEPDHAANIENFMKAYPDTIVVANTKTFTMMGNFFRNLNLDGKKLVVANGDSLTLGKHVLTFVFAPMVHWPEVMVTYDSTDKVLFSADGFGKFGALDVEEDWDCEARRYYIGIVGKYGAQVQKLLKAAATLDIQTICPLHGPILTENLGHYLEKYDIWSSYKVESEGVVIAYTSVYGNTKKAVELLTQKLEEKGCPKVTVFDLARDDMAEAVEEAFRYGKLVLATITYNGDIFPFMRTYIENLTERSYQNRTIGLIENGSWAPAAARIMQGMFEKSKNITWLENNVKITSSLSEANEAEIDAMAEELCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B2Y9</accession>
    <name>A0A174B2Y9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200119.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95451">
        <property type="protein sequence ID" value="CUN95451"/>
        <property type="gene ID" value="ERS852478_01480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN95451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="98" mass="11299" checksum="F059E32A6B834A04" modified="2016-09-07" version="1">MNKTESVAGKATRRMQLKNMPFDRFEDGVGFIHATGCDCFVDGEWVTEYEDGIYEDAPGCIYEDEEDDEPEWTEEDETQYAETFEPYPGFENFKLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B839</accession>
    <name>A0A174B839_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF3801)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200123.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97132">
        <property type="protein sequence ID" value="CUN97132"/>
        <property type="gene ID" value="ERS852478_01525"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024234">
        <property type="entry name" value="DUF3801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12687">
        <property type="entry name" value="DUF3801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN97132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="158" mass="17861" checksum="BC7DBF7335261CD0" modified="2016-09-07" version="1">MQEEVDQKTIALAVKTGKLTAQVLQAAIRKYLSARQKGTGKAHHGQQSLRQLKKDGSALSNIEITDANIGLFKPCAKKYDIDFTLRKDRTTHPPRYIVIFKSKQADNLEQAFKEFTAKKLQQQERPSIRKTLAVLKEKAAARSSQQAKEKIKERGLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BFS7</accession>
    <name>A0A174BFS7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoteichoic acid synthase 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Sulfatase-like hydrolase/transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ltaS1</name>
        <name evidence="3" type="ORF">ERS852478_01570</name>
        <name evidence="4" type="ORF">GT712_09080</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060204.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99597">
        <property type="protein sequence ID" value="CUN99597"/>
        <property type="gene ID" value="ERS852478_01570"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="237"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN99597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="678" mass="78156" checksum="22F60D3099573240" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BG97</accession>
    <name>A0A174BG97_9FIRM</name>
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        <submittedName>
            <fullName evidence="2">Replication initiator protein A (RepA) N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Blautia</taxon>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00052">
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        <property type="gene ID" value="ERS852478_01584"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010724">
        <property type="entry name" value="RepA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06970">
        <property type="entry name" value="RepA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RepA_N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO00052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="293" mass="33961" checksum="F16B731015EED8F2" modified="2016-09-07" version="1">MSKMEYMPVDCLQVPKMLFQMEKYKNLSNTAKILYSLFLDRLKFAVQNGWVDGEGDLFVIYPKSEMKKDLNTTRYGVDQAVQELVEVGNLVRIISDNGKAKHFYINDIYENEMEKESMMTLDSIMANMPMEEREIIMDKMVKASRDILETIADMGYLDEYETPLTSMEERNYRDELGQLDIDQISCDGYEFGMDLAFGILEENEENADRVLDIQKYVNRQHKKCSKKKFMKVLETLVHAIGNDEGFIADMYACDKEARKIYLEEAVNAFNYVLDELCHGTGSAAGYDFNNMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BGP4</accession>
    <name>A0A174BGP4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_00237</name>
        <name evidence="1" type="ORF">ERS852478_01572</name>
        <name evidence="2" type="ORF">ERS852523_01313</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP34193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707227.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000057_gene2522"/>
    <dbReference type="EnsemblBacteria" id="CUN99663">
        <property type="protein sequence ID" value="CUN99663"/>
        <property type="gene ID" value="ERS852478_01572"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP34193">
        <property type="protein sequence ID" value="CUP34193"/>
        <property type="gene ID" value="ERS852523_01313"/>
    </dbReference>
    <dbReference type="GeneID" id="66496103"/>
    <dbReference type="eggNOG" id="ENOG5033A54">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN99663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP34193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX67396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="50" mass="5842" checksum="181CADE2A5F887BB" modified="2016-09-07" version="1">MIDYEEELKKFEPCLDVADAEGAIYERELTDILDILQEVLREAKSGRRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BKM3</accession>
    <name>A0A174BKM3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_024720755.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01601">
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        <property type="gene ID" value="ERS852478_01626"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_5" evidence="1">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO01601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="144" mass="16019" checksum="5B1F8F41392444CE" modified="2016-09-07" version="1">MRTAIVYASVHHGNTEKLVKRIAEECQVDLIDAVKQPDADLSSYDMIGFASGIYFSKFHQSILEFAEKNLPDDKKIFLICTYGGSANYKTIEQILDKRHASVVGKFGCKGYDTFGPFKLVGGIAKDHPNEEDMKNAADFVKGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BPS7</accession>
    <name>A0A174BPS7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Group II intron-encoded protein ltrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ltrA_2</name>
        <name evidence="2" type="ORF">ERS852478_01630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057330.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01685">
        <property type="protein sequence ID" value="CUO01685"/>
        <property type="gene ID" value="ERS852478_01630"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025960">
        <property type="entry name" value="RVT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13655">
        <property type="entry name" value="RVT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="92"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO01685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="489" mass="57246" checksum="6B571CCE2F8B0403" modified="2016-09-07" version="1">MYEKSCASSNHIKSWKDIDFGTAEYEVKKLQMRIAKAVKENRVGKIKSLQWTLTHSFYAKAIAVKRVTENKGKRTPGVDGVCWISNEDKFNAIFTLQRRGYQPQPLRRIYIPKKNGKKRPLSIPTMKDRAMQTLHKMALEPVTETLADGTSYGFRPNRCVQDAIEQCFVDLARKTAPEWVLEGDIKGCFDNINHEWMQKNIPMDKEILHKFLKAGFVEKGKLNATDQGTPQGGTISPTLCNYVLDGLERLLKNKFKRYWSKGRQINPKVNLVRYADDFIITGVSEELLRNEVLPLVKEFMHERGLELSDEKTVITNIHDGFDFLGCNIRKYGDKLLTKPSKQNVKSIMRKIRGTIKKFRTGKQSDLIKCLNPIIRGWVNFQKYNVSSVAFRYVDWQTFKALWRWCRRRHKNKPAAWIRDKYFHRIGNRSWTFSEKLTEDNYLALVYATDTNITRFTCIKAEANPYDEIWMEYFAERKNKSYSNFKFVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BQS4</accession>
    <name>A0A174BQS4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rplF</name>
        <name evidence="7" type="ORF">ERS852478_01672</name>
        <name evidence="8" type="ORF">ERS852523_01280</name>
        <name evidence="10" type="ORF">GT712_08915</name>
        <name evidence="9" type="ORF">GT728_04765</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
            <strain evidence="8 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BIOML-A1</strain>
            <strain evidence="10 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579624.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2969"/>
    <dbReference type="EnsemblBacteria" id="CUO03094">
        <property type="protein sequence ID" value="CUO03094"/>
        <property type="gene ID" value="ERS852478_01672"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33203">
        <property type="protein sequence ID" value="CUP33203"/>
        <property type="gene ID" value="ERS852523_01280"/>
    </dbReference>
    <dbReference type="GeneID" id="66496135"/>
    <dbReference type="eggNOG" id="COG0097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="92"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO03094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP33203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL32531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS89188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="179" mass="19496" checksum="1FF3629E34203768" modified="2016-09-07" version="1">MSRIGRLPVAIPAGVEVTVAEGNVVTVKGPKGTLERALPTEMEIKVEDGHVVVSRPNDLKKMKSLHGLTRSLIHNMVVGVSEGYTKELEVNGVGYKAAKQGKKLVLSLGYSHPVEMEDPDGIETKVDGNKIIVSGISKEKVGQFAAEIRDKRRPEPYKGKGIKYVDEVIRRKVGKTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BTW9</accession>
    <name>A0A174BTW9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rplE</name>
        <name evidence="13" type="ORF">BWLFYP14_00267</name>
        <name evidence="9" type="ORF">ERS852478_01669</name>
        <name evidence="10" type="ORF">ERS852523_01283</name>
        <name evidence="12" type="ORF">GT712_08930</name>
        <name evidence="11" type="ORF">GT728_04750</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707267.1">
        <property type="nucleotide sequence ID" value="NZ_JADPFJ010000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2972"/>
    <dbReference type="EnsemblBacteria" id="CUO02986">
        <property type="protein sequence ID" value="CUO02986"/>
        <property type="gene ID" value="ERS852478_01669"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33300">
        <property type="protein sequence ID" value="CUP33300"/>
        <property type="gene ID" value="ERS852523_01283"/>
    </dbReference>
    <dbReference type="GeneID" id="66496132"/>
    <dbReference type="eggNOG" id="COG0094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="84"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO02986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP33300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL32528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS89191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX67426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="179" mass="20262" checksum="5F8AF3265B8BA519" modified="2016-09-07" version="1">MSRLKEMYKNEIMDAMTKKFGYKNVMEVPKLDKIVINMGVGEAKENAKLLDAAIADMELITGQKAIATKAKKSVANFKIREGMPIGCKVTLRGEKMYEFADRLINLALPRVRDFRGVNPNAFDGRGNYALGIKEQLIFPEVEYDKVDKVRGMDIIFVTTAKTDEEARELLTLFNMPFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BV58</accession>
    <name>A0A174BV58_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rpsK</name>
        <name evidence="9" type="ORF">ERS852478_01682</name>
        <name evidence="10" type="ORF">ERS852523_01270</name>
        <name evidence="12" type="ORF">GT712_08860</name>
        <name evidence="11" type="ORF">GT728_04820</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">2789STDY5834863</strain>
            <strain evidence="10 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 16">BIOML-A1</strain>
            <strain evidence="12 15">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP32910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707283.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2958"/>
    <dbReference type="EnsemblBacteria" id="CUO03478">
        <property type="protein sequence ID" value="CUO03478"/>
        <property type="gene ID" value="ERS852478_01682"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP32910">
        <property type="protein sequence ID" value="CUP32910"/>
        <property type="gene ID" value="ERS852523_01270"/>
    </dbReference>
    <dbReference type="GeneID" id="66496146"/>
    <dbReference type="eggNOG" id="COG0100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO03478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP32910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL32542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS89177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="131" mass="13930" checksum="AB19555EC4F9EB4F" modified="2016-09-07" version="1">MAKVTKKATAKRRVKKNVEHGQAHIQSSFNNTIVTLTDNEGNALSWASAGGLGFRGSRKSTPYAAQMAAETATKAALIHGLKTVDVMVKGPGSGREAAIRALQACGLEVTSIRDVTPVPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C1A5</accession>
    <name>A0A174C1A5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General stress protein 16U</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yceD_1</name>
        <name evidence="3" type="ORF">ERS852478_01726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAPAB/TerDEXZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200187.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05685">
        <property type="protein sequence ID" value="CUO05685"/>
        <property type="gene ID" value="ERS852478_01726"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO05685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="193" mass="20704" checksum="1BA22D487872EE79" modified="2016-09-07" version="1">MPVSLKKGQKVSLTKGNPGLKNVVVGIGWDINAFDTGGDFDLDAAAFCLTDSGRVSDSNDFVFYGNLVHPSGAVQHMGDNLTGAGDGDDEQIKIDLSKIPANITKIAFTVTIYDAEARRQNFGQVSNAFVRIFNEVTGEEILRYDLGEDFSIETAVVFGELYKNGGEWKFNAIGSGYQGGLAALCNSYGVDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C4T7</accession>
    <name>A0A174C4T7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-tagatose-1,6-bisphosphate aldolase subunit GatY</fullName>
            <ecNumber evidence="4">4.1.2.40</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Ketose-bisphosphate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gatY_2</name>
        <name evidence="4" type="ORF">ERS852478_01813</name>
        <name evidence="5" type="ORF">GT728_20685</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.40" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000107">
        <property type="protein sequence ID" value="MZL35514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578020.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000107.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08422">
        <property type="protein sequence ID" value="CUO08422"/>
        <property type="gene ID" value="ERS852478_01813"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009025">
        <property type="term" value="F:tagatose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="230"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO08422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL35514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="283" mass="31609" checksum="B95B1FF480DD5992" modified="2016-09-07" version="1">MLVTSKEMLEKARREHYAVPAMNTQGGNYDIIWAICRAAEEMHSPAILAHYVATGAYSGDDWFVEVCKWCANKVSVPIAIHLDHGDSFDICMKSLKNGFTSLMIDGSTKPIEENARLTNEVIKVAKCFDVPVEAEIGELLRLDEAGAQMENKNVANPEQVRQFLDLCQPDSLAIGIGNAHGYYKGEPDIKLEVLEEVRKFTDIPFVLHGCTGMREDIIKEAIKLGVAKINFGTEIRYKYVEHYEEALKTNHQGHSWKLSQLANDALTEDIKKIIRLAGSEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C6T4</accession>
    <name>A0A174C6T4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ctc</name>
        <name evidence="6" type="synonym">rplY</name>
        <name evidence="8" type="ORF">ERS852478_01783</name>
        <name evidence="9" type="ORF">ERS852523_02379</name>
        <name evidence="10" type="ORF">GT712_12005</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
            <strain evidence="9 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000024">
        <property type="protein sequence ID" value="CUP66414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055054124.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000057.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000147_gene3487"/>
    <dbReference type="EnsemblBacteria" id="CUO07416">
        <property type="protein sequence ID" value="CUO07416"/>
        <property type="gene ID" value="ERS852478_01783"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP66414">
        <property type="protein sequence ID" value="CUP66414"/>
        <property type="gene ID" value="ERS852523_02379"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="7">
        <location>
            <begin position="97"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO07416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP66414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS89776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="198" mass="21778" checksum="063E63CCFB715C06" modified="2016-09-07" version="1">MNTLKAEKRTMDTKAKRLRREGYVTGNVFGREMEGSLPVKIEKSAVEKLLKTNNKGSQIMLDVDGQSYDVLIKEIQFNPLKGQVDEIDFQALVSNEKVHSVAEIVLVNHDKLEAGVLQQHLEEISFRALPSALVDKVMVDVGDMKVGDVIKVKDLAIAQDKDVDLKTDLEAAVVSVAAVHVDPALEAEEEAAAEEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C6V8</accession>
    <name>A0A174C6V8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200310.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08894">
        <property type="protein sequence ID" value="CUO08894"/>
        <property type="gene ID" value="ERS852478_01828"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZCWE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO08894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="188" mass="22141" checksum="349199C0C4296CBD" modified="2016-09-07" version="1">MNSSFWISIFIQRKDGKKVMNYKIVEQVSRKKKSMSGVLRVVMIIFAVLFVVMGITISQAFMLPGFLLAGLYFVFDIFSQRDYEYKMENGQLEIDVIYGKKYRKTAHILELSNLETVAPHWHESVARYKKNGGTEKLKKYDYTSYDEDTPYYTMIIREDGHKIKLLLDLNEELLHAMKTQYPEKVYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CAS4</accession>
    <name>A0A174CAS4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO09887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200337.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09887">
        <property type="protein sequence ID" value="CUO09887"/>
        <property type="gene ID" value="ERS852478_01837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO09887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="684" mass="78805" checksum="BB582278F0656366" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CG17</accession>
    <name>A0A174CG17_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prpC_1</name>
        <name evidence="7" type="synonym">prpC</name>
        <name evidence="10" type="ORF">BWLFYP14_02225</name>
        <name evidence="6" type="ORF">ERS852478_01904</name>
        <name evidence="7" type="ORF">ERS852523_01958</name>
        <name evidence="9" type="ORF">GT712_17525</name>
        <name evidence="8" type="ORF">GT728_10815</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000018">
        <property type="protein sequence ID" value="CUP54199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000023">
        <property type="protein sequence ID" value="MZL33677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000051">
        <property type="protein sequence ID" value="MZS90808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703524.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000004_gene1944"/>
    <dbReference type="EnsemblBacteria" id="CUO11907">
        <property type="protein sequence ID" value="CUO11907"/>
        <property type="gene ID" value="ERS852478_01904"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP54199">
        <property type="protein sequence ID" value="CUP54199"/>
        <property type="gene ID" value="ERS852523_01958"/>
    </dbReference>
    <dbReference type="GeneID" id="66493890"/>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO11907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP54199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL33677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS90808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX65860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="453" mass="51247" checksum="C44D9CC91D81914E" modified="2016-09-07" version="1">MAGFKTKVTPEIENLTEVCKEHTSLDLSLYAKYDVKRGLRDINGKGVLAGLTQVSNVKATKIVDGKEVPCAGSLSYRGYDIKDLTRGFIEDDRYGFEEVTYLLLFGSLPDKKQLADFTQLLANQRSLPTNFVRDVIMKAPSKDIMNGLSRSVLTLYSYDTNPDDTSLPNVLRQCLNLISVFPLLSVYGYQAYNHYIKDKSLYIHNPKKELTTAENILRMLRPDKKYSHLEAKILDIALILHMEHGGGNNSTFTTHVVSSSGTDTYSAIAAALGSLKGPKHGGANIKVVRMFDDMKKEVKDWKDEDEVRTYLKRLLHKEAFDRKGLIYGMGHAIYSVSDPRAEVFKAYVETLAREKGRMKDYALYSMVERLAPEVIAEERRIYKGVSANVDFYSGFVYSMLDLPLELYTPMFAVARIVGWSAHRMEELINADKIIRPAYKNVLEPAVYVPLNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CGK3</accession>
    <name>A0A174CGK3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase I</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">polA_1</name>
        <name evidence="2" type="ORF">ERS852478_01877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200464.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11120">
        <property type="protein sequence ID" value="CUO11120"/>
        <property type="gene ID" value="ERS852478_01877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038969">
        <property type="entry name" value="FEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42646">
        <property type="entry name" value="PTHR42646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO11120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="346" mass="39487" checksum="322BDECCCE251317" modified="2016-09-07" version="1">MPKLLIIDGSSMLSTSYYGNLPKSILFAKTEEEKEKHYGQILHTSDGKYTNAMFTMLRTLLGIYKKVKAEYVAFVFDKTRDTFRRTELGADFYKANRKETAKPLKEQFIQMEEFLQEIGCAVFMSDDYEADDYAASLVEKFEGPDLQTYVLTKDHDYFQVVSEYTRMWRVVNKDKLEQLKETYGLFGNDVYESLPANVFEYTPEIVYAEEGVYPQQIPVLLAITGDPGDGIPGCKGVSSAAASLVDEYKSLDEIYAAIDDCEGVAKKEKELNGFWKEYLGIGRSPLKALKTNREMVYLSEKLATMKRDIDISCGIEDLKLCVDIDKLKEELGRYEMSSLIKEVENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CJM0</accession>
    <name>A0A174CJM0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02180</name>
        <name evidence="4" type="ORF">ERS852478_01953</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703592.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13552">
        <property type="protein sequence ID" value="CUO13552"/>
        <property type="gene ID" value="ERS852478_01953"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO13552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="442" mass="51584" checksum="E4414767675B2716" modified="2016-09-07" version="1">MRTVSSYGVELRKQNIPIRQTLDIYRSAVSCLIEIYAQIWDELAVITEPKNRFNTAEHLVHTTKKNQARFDFDLRFPKMPSYLRRAAIQHALGSVSSYKTRMELWKKTDQKGGRPKLVCDNHAMPVFYRDVMYREDTEEKDGACLKLYDGHDWKWFRVSLSHTDMEYLRKNWAGKKAAAPVLEKRHRKYFLRFSYTEEVPLTKTPVKEQIICSVDLGLNTDAVCTIMRADGTVLGRKFIDFPSEKDRMYRVLGRISRFQRKHGSAQVKSRWAYAKRLNTELGRKIAGAVTGYAEENHVDVIVFEYLEIKGKISGRKKQKLHLWRKRDIQKRCEHQAHRRGMRISRICAWNTSRLAYDGSGTVVRDPGNHSLCTFQNGKRYNCDLSASYNIGARYFIRELLKPIPVTERSLLEAKVPSVKRRISCVYADLRELFLEMELLRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CRF4</accession>
    <name>A0A174CRF4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exodeoxyribonuclease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="3 4">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">exoA</name>
        <name evidence="4" type="synonym">xth</name>
        <name evidence="3" type="ORF">ERS852478_02011</name>
        <name evidence="4" type="ORF">GT712_10250</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="3 4"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000018">
        <property type="protein sequence ID" value="MZS89439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380970.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16141">
        <property type="protein sequence ID" value="CUO16141"/>
        <property type="gene ID" value="ERS852478_02011"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO16141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="251" mass="29353" checksum="DE72FEB0B49EEB08" modified="2016-09-07" version="1">MKLISWNVNGIRACIGKGFEESFAALDADIFCLQETKCQQGQVKLELPGYYQYWNYANRRGYSGTAVFTKKEPLSVVYGIGIEEHDKEGRVITLEYEKFYLVTVYTPNSQSELRRLEYRMHWEEDFLAYLLKLQESKPVICCGDFNVAHQEIDLKNPKTNRKNAGFTDEERACFGKVLESGFIDTFRYFYPDVEGRYSWWSYRFKAREKNAGWRIDYFITSPQLKDKLKGAEIHSEIMGSDHCPVELQITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CX34</accession>
    <name>A0A174CX34_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Polynucleotide phosphorylase</fullName>
            <shortName evidence="7">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pnp</name>
        <name evidence="12" type="ORF">BWLFYP14_00437</name>
        <name evidence="9" type="ORF">ERS852478_02017</name>
        <name evidence="11" type="ORF">GT712_10220</name>
        <name evidence="10" type="ORF">GT728_08845</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 16">BIOML-A1</strain>
            <strain evidence="11 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000018">
        <property type="protein sequence ID" value="MZS89433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707578.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16325">
        <property type="protein sequence ID" value="CUO16325"/>
        <property type="gene ID" value="ERS852478_02017"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="623"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO16325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL33299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS89433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX62356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="697" mass="76854" checksum="E284817B40841697" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CXK8</accession>
    <name>A0A174CXK8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease R</fullName>
            <shortName evidence="6">RNase R</shortName>
            <ecNumber evidence="6">3.1.13.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rnr</name>
        <name evidence="10" type="ORF">ERS852478_02070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNR ribonuclease family. RNase R subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200533.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17974">
        <property type="protein sequence ID" value="CUO17974"/>
        <property type="gene ID" value="ERS852478_02070"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01895">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040476">
        <property type="entry name" value="CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013223">
        <property type="entry name" value="RNase_B_OB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004476">
        <property type="entry name" value="RNase_II/RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011805">
        <property type="entry name" value="RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17876">
        <property type="entry name" value="CSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08206">
        <property type="entry name" value="OB_RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00358">
        <property type="entry name" value="3_prime_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02063">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="670"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO17974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="760" mass="87186" checksum="492068BA99A84189" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D9C3</accession>
    <name>A0A174D9C3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">mnmG</name>
        <name evidence="11" type="synonym">gidA</name>
        <name evidence="14" type="ORF">ERS852478_02181</name>
        <name evidence="15" type="ORF">GT712_11415</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060218.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22063">
        <property type="protein sequence ID" value="CUO22063"/>
        <property type="gene ID" value="ERS852478_02181"/>
    </dbReference>
    <dbReference type="GeneID" id="66493373"/>
    <dbReference type="eggNOG" id="COG0445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="12">
        <location>
            <begin position="9"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="GIDA_C" evidence="13">
        <location>
            <begin position="403"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO22063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZS89664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="624" mass="69681" checksum="151F199D27A148CA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DA05</accession>
    <name>A0A174DA05_9FIRM</name>
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        <submittedName>
            <fullName evidence="8">Predicted outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_02138</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200569.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20716">
        <property type="protein sequence ID" value="CUO20716"/>
        <property type="gene ID" value="ERS852478_02138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041033">
        <property type="entry name" value="Prealbumin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041100">
        <property type="entry name" value="TQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17802">
        <property type="entry name" value="SpaA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18202">
        <property type="entry name" value="TQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019865" evidence="6">
        <location>
            <begin position="30"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="989"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="7">
        <location>
            <begin position="980"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="932"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="932"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="966"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO20716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1016" mass="111364" checksum="04A3EE91CD2E95C1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DE61</accession>
    <name>A0A174DE61_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">dnaN_2</name>
        <name evidence="15" type="ORF">ERS852478_02189</name>
        <name evidence="16" type="ORF">GT712_11375</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 18">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708002.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22325">
        <property type="protein sequence ID" value="CUO22325"/>
        <property type="gene ID" value="ERS852478_02189"/>
    </dbReference>
    <dbReference type="GeneID" id="66493381"/>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7 11 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="12">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="13">
        <location>
            <begin position="129"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="14">
        <location>
            <begin position="247"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO22325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZS89656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="371" mass="42437" checksum="B80B22E84E37312A" modified="2016-09-07" version="1">MKIICQKINLLKSVNISLKAVPSKTTMPILECILIDATTNQIKFTTNDMELGIETIVDGIIEEKGIIALDAKIFYEIIRRLPDNTVTIKTDEKLTATITCEKAKFTIPGKSGEDFAYLPLIEKEESLTISQFTLKEMIRQTIFSIASNETNKLMTGELFEIKNNYLKIVSLDGHRIAIRRMELKKDYADRKVVVPGKTLNEISKILSGEIDDIVNIYFSKNHILFEFDQTIVVSRLIDGEYFRIDQMLSSDYETKIKINKKEFLDCIDRATLLVREGEKKPIIIEITDNSMELRIDSAMGSMNENIDIDKEGKDILIGFNPRFLIDALKVIDDETISIYLVNPKAPCFIRDDEENYTYLILPVNINQNQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DNS5</accession>
    <name>A0A174DNS5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensory histidine kinase DcuS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25949">
        <property type="protein sequence ID" value="CUO25949"/>
        <property type="gene ID" value="ERS852478_02290"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="2">
        <location>
            <begin position="312"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO25949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="413" mass="47078" checksum="CD700A28DAD1707C" modified="2016-09-07" version="1">MFALITTLSTNLLRTYIIYRFMRLFFWTDIEEKKKERACYVLFFVLTAGVHLIFCSPGMSVITNIVLIFLITVCYEGALKKKIFVTLLVYGTNMGCDLVAVHLLTDYSITGKVGECAAYITVLLLLICDVISEKILIKNKGEDKTPHGMILAVISALCLAELLIVEQELKNRILLVLFGCCVLAVVLLIFYLYDVLISAYKKLEEQSLMEKQMLIYSHQLDVLMQSEEKVKALRHDMKNHLGELALMAGNQNNEEIRKYIQDMGEYMQNQSELVSCGNKNLDSLLNYLLGQAKKKLNHVEYEVRVPSDLCISAFDLNVILGNLTENAIEAAEQTKDKWMSVDIYYEKGMLSMEIKNSFQHELAVEKNKLLSTKEEKGHGIGLANVRKMVEKYQGFMDVSNTNQIFTVKVMLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DS19</accession>
    <name>A0A174DS19_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Elongation factor G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fusA_1</name>
        <name evidence="5" type="ORF">ERS852478_02350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200699.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28382">
        <property type="protein sequence ID" value="CUO28382"/>
        <property type="gene ID" value="ERS852478_02350"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="7"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO28382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="696" mass="77267" checksum="6A4B0A69CC570011" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DTB3</accession>
    <name>A0A174DTB3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Propanediol utilization protein PduU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pduU_2</name>
        <name evidence="3" type="ORF">ERS852478_02331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO27120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381075.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27120">
        <property type="protein sequence ID" value="CUO27120"/>
        <property type="gene ID" value="ERS852478_02331"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07046">
        <property type="entry name" value="BMC_PduU-EutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009307">
        <property type="entry name" value="EutS/PduU/CutR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40449">
        <property type="entry name" value="PTHR40449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="49"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO27120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="121" mass="13179" checksum="D312D948E9ACBF4E" modified="2016-09-07" version="1">MANDHVEHIRIVQETVAGKEITFAHVMGGPAPVIYQKLGLNPQVDYRSSAIGIMNMTPPESAVIASDIAVKSGNVYLGFADRFTGTLIITGEISDVMSAMTEIVDYFRDTLGYVVCKITKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DW45</accession>
    <name>A0A174DW45_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase I</fullName>
            <ecNumber evidence="7">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">polA_2</name>
        <name evidence="7 11" type="synonym">polA</name>
        <name evidence="10" type="ORF">ERS852478_02394</name>
        <name evidence="11" type="ORF">GT712_04515</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Single-chain monomer with multiple functions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29812">
        <property type="protein sequence ID" value="CUO29812"/>
        <property type="gene ID" value="ERS852478_02394"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="8">
        <location>
            <begin position="3"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="9">
        <location>
            <begin position="676"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO29812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS88374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="918" mass="103301" checksum="CE810C93D0DA2B58" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DYK3</accession>
    <name>A0A174DYK3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rnc</name>
        <name evidence="13" type="ORF">BWLFYP14_00168</name>
        <name evidence="10" type="ORF">ERS852478_02367</name>
        <name evidence="12" type="ORF">GT712_04645</name>
        <name evidence="11" type="ORF">GT728_02205</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">BIOML-A1</strain>
            <strain evidence="12 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL32046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704699.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28940">
        <property type="protein sequence ID" value="CUO28940"/>
        <property type="gene ID" value="ERS852478_02367"/>
    </dbReference>
    <dbReference type="GeneID" id="66494255"/>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="5"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="158"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO28940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL32046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS88400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX66615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="227" mass="25452" checksum="0D21F8DB49479C67" modified="2016-09-07" version="1">MNRKTEELEEIIGYHFKNKHYLTQALTHSSYANEKKLGKLGSNERLEFLGDAVLELISSDYLYARFTQIPEGELTKKRASLVCEPSLAYCAREFGLPQFLLLGKGEDMTGGRNRDSIVSDATEALLGAIYLDGGFANAKEFVLNFILNDIEHKQLFYDSKTILQEIVQENGTQPVEYILTKEEGPDHNKNFTVEARVNGKVMGQGSGHTKKAAEQAAAYQAIRVLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E4Z9</accession>
    <name>A0A174E4Z9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">srrB_3</name>
        <name evidence="11" type="synonym">srrB_1</name>
        <name evidence="11" type="ORF">BWLFYP14_02150</name>
        <name evidence="10" type="ORF">ERS852478_02470</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703645.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32517">
        <property type="protein sequence ID" value="CUO32517"/>
        <property type="gene ID" value="ERS852478_02470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="196"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="263"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO32517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX65774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="473" mass="53768" checksum="118B5E5409CF713B" modified="2016-09-07" version="1">MKLLIKIFFQTTCIILLVSSGIFLYTTYCWKNQSIQNINSYESSIFRINILQFENKTSLSENQKQNADNEMRPQIVTYAFRQVFHDSAVLYLDGKMTYNGTVYEFDVKKLRELCASKANMVDHGSNSDGHGPMISQINGRTLLLFYYGNVNMGYQIVTYKDITDVIEKSHLLFFQTGGFTLSLIVVMGIILYLSLRKITAPLTSLREATLLVSEGIYDFKVPSEGNTELAQVGATFNFMTGKIKEQIESLSNINRTQKQLIGSLAHELKTPMTAIIGYADTLLTVRLTPERQEKALIYIENECRRLSRLSMKMLELTGLYEASEDSFNPVEIQVDNFLKEVKELIDCRLQEKNISLDVFCEPKELVKKFDQDLMISVVTNLIDNAVKASRKESKIVLEATPDHLMVQDFGKGIPKEDLEMVTEPFYMVDKSRSRAKGSVGLGLSLCHKIIELHDFQLKIESNQGKGTTVSVFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E7K2</accession>
    <name>A0A174E7K2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sulfate/thiosulfate import ATP-binding protein CysA</fullName>
            <ecNumber evidence="4">3.6.3.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cysA_1</name>
        <name evidence="4" type="ORF">ERS852478_02460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.25" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32265">
        <property type="protein sequence ID" value="CUO32265"/>
        <property type="gene ID" value="ERS852478_02460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="10"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO32265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="229" mass="25983" checksum="D63950E6A30052E7" modified="2016-09-07" version="1">MNGKGKIPKNRFQAIAKKYPLYLAIAGVAVSFIFSLENYAFEKGMVNFNVMDTYIYAVEMSGKTVLFKTICGFLSCDEGTVSVNGKVMGKDKDMLTEAGIIIEDPGFLRNWSAYHNLEFLYTIRNRPDKSYLHSVLNTVGLDSKLKRPVGKFSLGMRQRLALAQAIMEDPPILILDEPMNGLDKNGVAEIREFLLKMKNENRLIILASHNREDIEILCDEVYEMEYFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E7L1</accession>
    <name>A0A174E7L1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">srrA_2</name>
        <name evidence="11" type="synonym">srrA_1</name>
        <name evidence="11" type="ORF">BWLFYP14_02149</name>
        <name evidence="9" type="ORF">ERS852478_02471</name>
        <name evidence="10" type="ORF">GT728_15205</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
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            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32548">
        <property type="protein sequence ID" value="CUO32548"/>
        <property type="gene ID" value="ERS852478_02471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
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        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Trans_reg_C"/>
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    </dbReference>
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        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OMPR_PHOB"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
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        <location>
            <begin position="4"/>
            <end position="117"/>
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            <end position="219"/>
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            <position position="54"/>
        </location>
    </feature>
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        <source>
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    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO32548.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX65772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="221" mass="25244" checksum="739B19B3A5A860EC" modified="2016-09-07" version="1">MKARILVIEDEMSINDLLCMNLEIAGYETVGYLDGNEAYEAIIQDHAFQCALVDIMLPGRDGYSLLPKLKQYEIPVIFLTAKGDIASKIKGLKDGAEDYIVKPFEMLEVMVRLEKVLERNGTVQEQIQIGDVIIDTASRTVTKLGMEIYLKPMEYNCLMVFAKNPNKALTRNQILQELWNEEFCGETRTVDAHVGRIRKKLGWQDKIKTIPRIGYRLEVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EDX7</accession>
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        </submittedName>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF3789)</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ERS852478_02544</name>
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        <name type="scientific">Blautia wexlerae</name>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
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                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ERS852478_02544"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO34978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL35299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="44" mass="4847" checksum="5C7D9AD61E477EE9" modified="2016-09-07" version="1">MWELLKDFLLVSVGTGIGVALMCILSVGKGADYEMKKLKESEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EIF1</accession>
    <name>A0A174EIF1_9FIRM</name>
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        <submittedName>
            <fullName evidence="4">Cobalt transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_02456</name>
        <name evidence="2" type="ORF">ERS852478_02588</name>
        <name evidence="3" type="ORF">ERS852523_00185</name>
        <name evidence="5" type="ORF">GT712_07315</name>
        <name evidence="4" type="ORF">GT728_02685</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000002">
        <property type="protein sequence ID" value="CUO99681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000011">
        <property type="protein sequence ID" value="MZS88879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000050">
        <property type="protein sequence ID" value="VUX66084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CUO36296">
        <property type="protein sequence ID" value="CUO36296"/>
        <property type="gene ID" value="ERS852478_02588"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99681">
        <property type="protein sequence ID" value="CUO99681"/>
        <property type="gene ID" value="ERS852523_00185"/>
    </dbReference>
    <dbReference type="GeneID" id="66494125"/>
    <dbReference type="eggNOG" id="ENOG5032WBX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO36296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO99681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="131" mass="14535" checksum="6FF6D076C2C10289" modified="2016-09-07" version="1">MHLIKDENGNLVQHGHGHTHEHTHEDGMTHTHEHTHGEGHDHGHSHADHACDTAHCGSCSEGDCKNETLALLTYMLQHNEHHAQELDQMADNLAKMGMDAACKTIKEAVADFQKGNMRLGLALTLVKEEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EIQ5</accession>
    <name>A0A174EIQ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">D-alanyl-D-alanine carboxypeptidase dacB</fullName>
            <ecNumber evidence="11">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dacB_5</name>
        <name evidence="11" type="ORF">ERS852478_02628</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO37812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060106.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37812">
        <property type="protein sequence ID" value="CUO37812"/>
        <property type="gene ID" value="ERS852478_02628"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020779" evidence="9">
        <location>
            <begin position="33"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="62"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO37812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="411" mass="45437" checksum="025DF38FDE0192AA" modified="2016-09-07" version="1">MFKTKFHKLMKRFLTGMLCAGILTSQPAVTYAAETSATPEAGHSETYSQASDIDSVKGWPTGPNIEGQSAVLMDAVTDTILYSKNAKDKLYPASITKIMTALLACEYLDMNDTITMSQEAAYGIEAGSSSIYAETGEVFTVEQALMALMLESANEMALALAEKTSGSVKKFVELMNQRAAQLGCKNTHFNNPNGLPDETHYTTAGDMMKIAKAAWYNPRFRKFVTTQVYEIPPTNKQSETRYLLNHHKMMPGQSYAYDGVLGGKTGYTDAAGSTLVTYAKRGNSILIAVVLNSTNGAFPDTTSLLDYGFDNFEKVDLNIDTDPVPAVFLPCEKHLLKDWNNLCSFYYMRHVYVTVPTGTDVSQLVKKQKLLNNSVGPKRIKSKYYLDGHMVGYGMQYEKEILSDFLLNASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EQT5</accession>
    <name>A0A174EQT5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TraX protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO39038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39038">
        <property type="protein sequence ID" value="CUO39038"/>
        <property type="gene ID" value="ERS852478_02668"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031QMC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008875">
        <property type="entry name" value="TraX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05857">
        <property type="entry name" value="TraX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO39038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="258" mass="28922" checksum="98D8A5F8C7779A64" modified="2016-09-07" version="1">MNMTTGRRGIVWKTPDITADGLKMFACITMLIQTVGIAIIEKGLIHLDQYTQESLNQAMSQDSRLMTLAGVGSIMQLIGGMAIPVFAFLLVEGFRNTSDYKKYLIMMAVTALVSEIPYDLAICGKVWDFSSQNAMITMCICLIMLKCLDLFKETSGFIGGMLKVLILIAAIVWVSIFRAEYGLCIVLLVFVFYVFETRNVLKTVLGCIISLMYVTGPIAFYGIWCCTGERKDYINKYVYYAFYPLHLLVLGVIANYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ERQ7</accession>
    <name>A0A174ERQ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GIY-YIG nuclease superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02677</name>
        <name evidence="3" type="ORF">ERS852523_02272</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO39296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000023">
        <property type="protein sequence ID" value="CUP63567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000115_gene2453"/>
    <dbReference type="EnsemblBacteria" id="CUO39296">
        <property type="protein sequence ID" value="CUO39296"/>
        <property type="gene ID" value="ERS852478_02677"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP63567">
        <property type="protein sequence ID" value="CUP63567"/>
        <property type="gene ID" value="ERS852523_02272"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO39296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP63567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="81" mass="9674" checksum="C69318A94A8B10FF" modified="2016-09-07" version="1">MMNYTYIVKCADGTLYTGWTNCLQKRMKAHNEGKNGAKYTRTKRPVTLVYYEGFSTKEEAMRREYEIKQFTRNKKLELLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ESL2</accession>
    <name>A0A174ESL2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type uncharacterized transport system, permease component</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Branched-chain amino acid transport system / permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BWLFYP14_00576</name>
        <name evidence="7" type="ORF">ERS852478_02726</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707921.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40933">
        <property type="protein sequence ID" value="CUO40933"/>
        <property type="gene ID" value="ERS852478_02726"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO40933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX62798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="359" mass="39420" checksum="5F724BC8F57FA21A" modified="2016-09-07" version="1">MKKEPFLQVSKRRNKARWQERLLIRFIALILALIVCGAVIVALVKMNPVDVYKAIWDGAMGSDRRLWQTIRDTMVLLCISIGLAPAFKMKFWNIGAEGQILIGGACSAAVMIYAGDKMPTGLLLIVMFVASALGGMIWGMIPAVFKANWNTNETLFTLMLNYVAMQVVTYCIVFWENPKGSNTVGIINQATKGGWLPELFGQKYGWNVVIVLILTVGMFIYLKYCKQGYEIAVVGESENTARYAGIQVKKVIIRTMAISGAICGIAGFVIVSGASHTISTATAGGRGFTAIIVAWLSKFNTFIMVAVSFGIVFMNQGAVQIATQYGLNENASNVLLGIILFFLIGAEFFINYRVKRAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EV22</accession>
    <name>A0A174EV22_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssb_2</name>
        <name evidence="6" type="ORF">ERS852478_02735</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200869.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41167">
        <property type="protein sequence ID" value="CUO41167"/>
        <property type="gene ID" value="ERS852478_02735"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO41167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="151" mass="16577" checksum="227D348F9B889382" modified="2016-09-07" version="1">MNKVILMGRLTRDPEVRYSAGENALAIARYTLAVDRRFRRDGEATADFISCVSFGRTAEFAEKYFRQGLRIVVSGRIQTGSYTNRDGQKVYTTEVVVEEQEFAESKAASDNYVASHPQTSAPAPSMPAPGAASADGFMNIPDGIDEELPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EXM7</accession>
    <name>A0A174EXM7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40745">
        <property type="protein sequence ID" value="CUO40745"/>
        <property type="gene ID" value="ERS852478_02719"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO40745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="670" mass="76370" checksum="ED18A257D313E362" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EYN1</accession>
    <name>A0A174EYN1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxyphenylpyruvate dioxygenase and related hemolysins</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">VOC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02791</name>
        <name evidence="4" type="ORF">GT712_07055</name>
        <name evidence="3" type="ORF">GT728_08420</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000016">
        <property type="protein sequence ID" value="MZL33218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000010">
        <property type="protein sequence ID" value="MZS88834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059749.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43093">
        <property type="protein sequence ID" value="CUO43093"/>
        <property type="gene ID" value="ERS852478_02791"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO43093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="130" mass="14971" checksum="10B666AB15F24191" modified="2016-09-07" version="1">MDLKNYSTGVQHIGIPTNDIDKTVEFYHKLGFETAFETVNEEANEKVVFLKLGTLVVETYENHAAKMEHGAIDHVALDVRDIEEIFRYINEAGLNSTQDTIHFLPFWENGVKFFTIEGPNKEKVEFSQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F080</accession>
    <name>A0A174F080_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41700">
        <property type="protein sequence ID" value="CUO41700"/>
        <property type="gene ID" value="ERS852478_02754"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8CW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025945">
        <property type="entry name" value="DHHW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14286">
        <property type="entry name" value="DHHW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO41700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="397" mass="45157" checksum="27D3FE371D8FD4F6" modified="2016-09-07" version="1">MKKSLRNYRLFFHRMGLLFLFIPLIVLILSIVLPDRGFSEKENRVLSSLPHLNGSQIASGGFEKQFETYENDQFPLRDLWITLKAGTDRLMGKVESNGVYVGKSGYLMEEFKAPDQTQYDATVKAMTDFAQKHSDLKQYALIAPNSVNILSDRLPAFAPVQDQNSWLDSLSASLTDAGMTFIDVRSTFKDHKMEDLYYHTDHHWTTQGAYYAYLKAAKDMGIDTSADTYDKAPVTRSFQGTLSAKSGFRSGEKDEIDVFLPTGDQALSSVVNYVDEQKKSASFYDTEKLETRDKYALFFGGNHAQIKISTPTETDNTLLVLKDSYANSFIPFLAQHYRKIIMIDPRYYFGDLEQLMQVENVQEILYLYNANTFFTDTSLELALTTAEQDSSDTSDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FJK0</accession>
    <name>A0A174FJK0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L,D-transpeptidase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Uncharacterized vancomycin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_03022</name>
        <name evidence="6" type="ORF">GT712_01490</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50454">
        <property type="protein sequence ID" value="CUO50454"/>
        <property type="gene ID" value="ERS852478_03022"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038054">
        <property type="entry name" value="LD_TPept-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022029">
        <property type="entry name" value="PG-bd_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12229">
        <property type="entry name" value="PG_binding_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143985">
        <property type="entry name" value="SSF143985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PG_binding_4" evidence="4">
        <location>
            <begin position="78"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_4" evidence="4">
        <location>
            <begin position="213"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="3">
        <location>
            <begin position="338"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO50454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS87797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="459" mass="51638" checksum="45680819416D4BA4" modified="2016-09-07" version="1">MSSRKKIMITLIIILLLLTAGVYGYGVYYFTEHFLPGSMVNGFNCSYMTVSQSEELLTQKVGAYVLTIDTRNNGQESITAKQAGLSYDSDGSVDKLIRNQDRFTWFLAFNQHRNYEVSSSIKYDEQKTEAAISELKCMQQENMTEPSDAHIEEKDDKFVIVPEQEGTALKPEKTSQDIIDALVTGRTPVDLEADGCYKEPKVYQSDETLTKNCDLINKLTDVVITYDFDDCTETVDRDMIKNWLTTDENGLYTLDKKQIEAYISELAAKYDTVGTERTFNTYDGREITVSGGNYGWQIDQKAELKELTELIKNGETQVREPVYSHEGLVRKTNDIGYTYIEIDLTAQRMVFYKDGTPTADAQIVSGNPFVPNCATPVGCYTTGEMKSGCTVNGEDYPSAVNYWIPFDGNLGISDAPWRMDFGGQLYEFEGTHGSICAPSDQVQIIFSNVEKNTPIVIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FWG1</accession>
    <name>A0A174FWG1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201152.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53166">
        <property type="protein sequence ID" value="CUO53166"/>
        <property type="gene ID" value="ERS852478_03097"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO53166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="63" mass="7122" checksum="0148A79A7F1FE3B7" modified="2016-09-07" version="1">MTLFTDNPFEKMMIQKPDYGKGEKSPPELSSPRCAGCPYKGQSPCVGYCLKQVQEKKKTEPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FYV8</accession>
    <name>A0A174FYV8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53799">
        <property type="protein sequence ID" value="CUO53799"/>
        <property type="gene ID" value="ERS852478_03120"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50336V7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO53799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="56" mass="6789" checksum="37D6C653BE2021E3" modified="2016-09-07" version="1">MNKRIRKKQDKKITEAINGLIFIAERREQQRQAAIRRFVKRCEALYEQQQKEGLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G5R0</accession>
    <name>A0A174G5R0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methionine-binding lipoprotein metQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">metQ</name>
        <name evidence="7" type="ORF">ERS852478_03242</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NlpA lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380855.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57912">
        <property type="protein sequence ID" value="CUO57912"/>
        <property type="gene ID" value="ERS852478_03242"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004872">
        <property type="entry name" value="Lipoprotein_NlpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30429">
        <property type="entry name" value="PTHR30429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03180">
        <property type="entry name" value="Lipoprotein_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002854">
        <property type="entry name" value="MetQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022278" evidence="6">
        <location>
            <begin position="25"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO57912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="313" mass="33676" checksum="81D1DD97B6DD14C8" modified="2016-09-07" version="1">MKKLVAAVLTGVLVAGTLSTGVYAKDDDKTITVAASATPHAEILEEAKPLLEKEGYDLEVTVFDDYVRPNEVVESGEFDANYFQHIPYLDQFNEEKGTHLVNAGGIHYEPFGIYPGTKDSLDDLEDGDSIAVPNDTTNEARALLLLQDNGIITLKDGAGLNATVKDIAENPHNVEIVELEAAQVARVTGETAYVVLNGNYALEAGFSVGKDALAYEKSDSEAAKTYVNVIAVKEGNENSDKIKALVDVLKSDEIKDFINEKYDGAVIPFDDSADTEDAAAEETDSKDTDSKDEAKEDAAEENAETTEAAEDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G9X3</accession>
    <name>A0A174G9X3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">trpD</name>
        <name evidence="6" type="ORF">ERS852478_03231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381371.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57700">
        <property type="protein sequence ID" value="CUO57700"/>
        <property type="gene ID" value="ERS852478_03231"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="1 3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycos_trans_3N" evidence="5">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_3" evidence="4">
        <location>
            <begin position="73"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosylpyrophosphate binding" evidence="3">
        <location>
            <begin position="107"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO57700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="336" mass="35603" checksum="E5D7A9768C1E900A" modified="2016-09-07" version="1">MIKEAIIKLSKKQDLAYAEAEAVMDEIMSGQATPVQMSAYLTALALKGETIDEITASAAGMRAHCIKLLHNLDVLEIVGTGGDGSNSFNISTTSSLVIAAGGVPVAKHGNRAASSKSGAADVLEALGVKITLTPERSAEILKKINICFLFAQNYHIAMKYVAPIRKELGIRTVFNILGPLSNPAGANMELMGVYDQSLVEPLAQVMANLGVNRGMVVYGQDSLDEISMCAPTSVCEIRDGKFTSYEITPEQFGYERCEKGALTGGTPAENAEITKAILKGEEKGPKRQAVCLNAGTALYIAGKAASIEEGVKLAESLIDSGAALKKLEEFVEETNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GG97</accession>
    <name>A0A174GG97_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC-type transporter ATP-binding protein EcsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ecsA_3</name>
        <name evidence="2" type="synonym">ecsA_1</name>
        <name evidence="2" type="ORF">BWLFYP14_00744</name>
        <name evidence="1" type="ORF">ERS852478_03322</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000019">
        <property type="protein sequence ID" value="VUX62995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60577">
        <property type="protein sequence ID" value="CUO60577"/>
        <property type="gene ID" value="ERS852478_03322"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO60577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX62995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="113" mass="13004" checksum="0440437194046776" modified="2016-09-07" version="1">MGLKKYENYSPSELSKGTMQRLNNACAMIQEEKITIFDEPFSGLDPVQMKLLENVMVEFHKKEKGIYIISSHDIECLQNVCDKCLLLHNGQIREINTEEVDREKIAKILSEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GQQ9</accession>
    <name>A0A174GQQ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="7">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">tyrS</name>
        <name evidence="14" type="ORF">BWLFYP14_02942</name>
        <name evidence="10" type="ORF">ERS852478_03411</name>
        <name evidence="11" type="ORF">ERS852523_01087</name>
        <name evidence="13" type="ORF">GT712_13880</name>
        <name evidence="12" type="ORF">GT728_07780</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">2789STDY5834863</strain>
            <strain evidence="11 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 19">BIOML-A1</strain>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP26835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000014">
        <property type="protein sequence ID" value="MZL33105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000029">
        <property type="protein sequence ID" value="MZS90133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000072">
        <property type="protein sequence ID" value="VUX66666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704520.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1052"/>
    <dbReference type="EnsemblBacteria" id="CUO63508">
        <property type="protein sequence ID" value="CUO63508"/>
        <property type="gene ID" value="ERS852478_03411"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26835">
        <property type="protein sequence ID" value="CUP26835"/>
        <property type="gene ID" value="ERS852523_01087"/>
    </dbReference>
    <dbReference type="GeneID" id="66494221"/>
    <dbReference type="eggNOG" id="COG0162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="9">
        <location>
            <begin position="343"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="227"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO63508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP26835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL33105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS90133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX66666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="409" mass="46113" checksum="417DDAB301F23FBB" modified="2016-09-07" version="1">MTVWDELKARGLIAQVTDEEEIKEMVNNGKATFYIGFDPTADSLHVGHFMALCLMKRLQMAGNKPIALLGGGTGMIGDPSGRSDMRQMMTVETIQHNIDCFKKQMERFIDFSDGKALMVNNADWLMNLNYVEVLRDVGPHFSVNRMLSHECYKQRMERGLTFLEFNYMIMQSYDFYMLYQKYGCTMQFGGDDQWANMLGGTELIRRKLGKDAYAMTITLLLNSEGKKMGKTQSGAVWLDPEKTSPFDFYQYWRNVDDADVIKCMRLLTFLPLEEIDEMAKWEGSQLNKAKEILAYELTNLVHGEEEAKKAQEGARALFAGGADTAHMPTTELADEDFSEEGTIDLISMLVKAGMVPTRSEGRRAIEQGGVSIDGEKITDVKYTVAKDALTGEGVVLKKGKKKFNKVLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GW14</accession>
    <name>A0A174GW14_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">LexA repressor</fullName>
            <ecNumber evidence="2">3.4.21.88</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lexA_3</name>
        <name evidence="5" type="synonym">lexA_1</name>
        <name evidence="5" type="ORF">BWLFYP14_02340</name>
        <name evidence="2" type="ORF">ERS852478_03471</name>
        <name evidence="4" type="ORF">GT712_16575</name>
        <name evidence="3" type="ORF">GT728_16100</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.88" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993357.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65407">
        <property type="protein sequence ID" value="CUO65407"/>
        <property type="gene ID" value="ERS852478_03471"/>
    </dbReference>
    <dbReference type="GeneID" id="66493936"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="1">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO65407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="70" mass="8125" checksum="F7793BD92701501C" modified="2016-09-07" version="1">MKKVLTRKQKESYQCILNYTKEHGYPPTVREFGKLIGVRSTSSAFSRIKQLEQNGYIRRIPASPRAIEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GWJ2</accession>
    <name>A0A174GWJ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060660.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66933">
        <property type="protein sequence ID" value="CUO66933"/>
        <property type="gene ID" value="ERS852478_03521"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO66933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="166" mass="19426" checksum="41FA7C88FB814604" modified="2016-09-07" version="1">MDTKDTRQTYKQYKERQKRIAIKKSYDDKLEQSSNKIEDLYVQLEQIKAALNNQIETRQQIRNEMHREMLRQYNKDNTIEETIELAEKTTCSRDSIREIQNACSTGINVSTVDLDTIDKLIDIEQDICNEIPHTNFISDLLIRRGGHTKFPSEKNDVNEEDDANGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GXG9</accession>
    <name>A0A174GXG9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coenzyme A disulfide reductase</fullName>
            <ecNumber evidence="3">1.8.1.14</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
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                <person name="Groussin M."/>
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                <person name="Avila-Pacheco J."/>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="85" mass="9783" checksum="7A9ECE76EB2876F1" modified="2016-09-07" version="1">MELTPTLILNLALLIVPPVALVLVFRQWLARHIRWMVALTALCDVLLFWDELFYYESFGLFAVLLLVQLAATGAAAFRIYCKQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H291</accession>
    <name>A0A174H291_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69024">
        <property type="protein sequence ID" value="CUO69024"/>
        <property type="gene ID" value="ERS852478_03587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025957">
        <property type="entry name" value="Cys_rich_KTR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14205">
        <property type="entry name" value="Cys_rich_KTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO69024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="62" mass="7224" checksum="A20EB6D6DF8CCF7F" modified="2016-09-07" version="1">MEKTEFIRCPVCGNKTRDKIREDTILKNFPLFCPKCKSECLIDIEQFHITVIKAPDAQPQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H5N5</accession>
    <name>A0A174H5N5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68360">
        <property type="protein sequence ID" value="CUO68360"/>
        <property type="gene ID" value="ERS852478_03570"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO68360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="45" mass="5287" checksum="4DEE0636736F6181" modified="2016-09-07" version="1">MMQGGKDMSKEEVLLESIRNYFHVRKGLFSLDIVLADGRKLERYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HAX5</accession>
    <name>A0A174HAX5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Na+/Pi-cotransporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Na/Pi cotransporter family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Na/Pi-cotransporter II-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BWLFYP14_03558</name>
        <name evidence="8" type="ORF">ERS852478_03631</name>
        <name evidence="9" type="ORF">ERS852523_01458</name>
        <name evidence="11" type="ORF">GT712_01665</name>
        <name evidence="10" type="ORF">GT728_07500</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO70189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP38963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000013">
        <property type="protein sequence ID" value="MZL33050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706243.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70189">
        <property type="protein sequence ID" value="CUO70189"/>
        <property type="gene ID" value="ERS852478_03631"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP38963">
        <property type="protein sequence ID" value="CUP38963"/>
        <property type="gene ID" value="ERS852523_01458"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015114">
        <property type="term" value="F:phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030147">
        <property type="entry name" value="NptA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="PTHR10010"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="PTHR10010:SF46"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="7">
        <location>
            <begin position="361"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="7">
        <location>
            <begin position="467"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="362"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO70189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP38963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL33050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS87832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX67283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="602" mass="66413" checksum="A7A0740169BC86DC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HN69</accession>
    <name>A0A174HN69_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000048">
        <property type="protein sequence ID" value="CUO74325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704446.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74325">
        <property type="protein sequence ID" value="CUO74325"/>
        <property type="gene ID" value="ERS852478_03770"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11579">
        <property type="entry name" value="Glyco_tran_WbsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032719">
        <property type="entry name" value="WbsX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41244">
        <property type="entry name" value="PTHR41244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14307">
        <property type="entry name" value="Glyco_tran_WbsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO74325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="387" mass="46484" checksum="4B52FFDEBF35D62A" modified="2016-09-07" version="1">MKIIAFYLPQFHDIPENDEWWGKGFTEWVNVKKAQPLYKGHEQPRIPMNENYYNLLDDNVKIWQANIAKEYGIYGFCYYHYWFGGKLLLEKPMEQMLANPKVDIPFCISWANEPWTKAWVNESKVLIPQFYGGKKEWKEHFDYLLPFFKDNRYIKEDNKPLFIIYRAEVIDCLNDMLDYWTELARQNGFSGMKYAYQNLTFDLMPNRDDSRFDYNIEFQPSYAWNDLNNKSAVQKSKLWNFLRNIKRRIYAETEKRLGFDLQRYFNHKGKEKNASVLKTDYDEAWKAILEHIPENEKNIPGAFVGWDNTPRKGHRGQVYIGDTPEKLNKYMSKQIQRAKSIYKKDMIFMYAWNEWAEGGYLEPDERTGYKNLEAIRDALKANNEFPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HN75</accession>
    <name>A0A174HN75_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized ABC transporter ATP-binding protein HI_1252</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_03831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000056">
        <property type="protein sequence ID" value="CUO76413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201545.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76413">
        <property type="protein sequence ID" value="CUO76413"/>
        <property type="gene ID" value="ERS852478_03831"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="317"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="353"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO76413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="509" mass="57734" checksum="D06EAD1A755C6EBE" modified="2016-09-07" version="1">MSLLEITGLTHSFGENLLYKNAGFTLNKGEHIGIVGQNGTGKSTLIKICTDQIIPDSGRVIWQPNIMIGYLDQYAEIDHTFTMKEFLKSAFAKLFEIETQVMQLYEKAADGDMKNLELAAYYQEQLETHDFYSIDTAIERVANGLGLLAIGLDRPIIEMSGGQRAKVILAKLLLEKPDVLLLDEPTNFLDKDHVAWLAEYLSSLENAFLVVSHDFDFLDKIANRICDIDNDTITKYYGTYSEFLRKKTLLREDYIRQYSAQQKEIKKTEEFIRKNIAGRKAKMARGRQKQLDRMDKMEALEQKEIIPHFHFPVLPLTNTEHLLVKHLAVGYHYPVLSDIDFSIKGGQKVVITGFNGIGKSTLLKTLIGQIPSMQGHFKFSDQVTLGYFEQDLIWDEPEQTPIQIVSNVHPDMVIKDVRKHLARCGISSKHAMQAIGTLSGGEQAKVKMCLLTLIPCNFLIMDEPTNHLDVQAKEALKSALMDFAGTVLLVSHEEAFYREWAQRVISVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HP14</accession>
    <name>A0A174HP14_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Predicted transporter component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852478_03835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000059">
        <property type="protein sequence ID" value="CUO76692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201547.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76692">
        <property type="protein sequence ID" value="CUO76692"/>
        <property type="gene ID" value="ERS852478_03835"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026366">
        <property type="entry name" value="Seleno_YedE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04112">
        <property type="entry name" value="seleno_YedE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="209"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO76692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="360" mass="37246" checksum="42BDA8CDB7A387A9" modified="2016-09-07" version="1">MKNEKGTIVLAGGVIGLIAAILVFFGNPANMGFCIACFLRDTTGALGLHSAAAVQYIRPEIIGLVLGACIISLAKKEFRPRGGSAPVTRFTLGAFVMIGCLMFLGCPFRMILRLAGGDGNALFGLVGFVAGILTGTVFLKKGYTLKHSYKMPKLEGSIYPAFQIVMLLLLVAAPAFIHFTEPEGGPGAKHAAIVIALAAGIIVGILAQRTRLCMVGGIRDAVLFKEYKLLFGFAAILVTALVMNLILGAVTGTSYFNPGFAGQPIAHTDGLWNALGMYLAGFGCILLGGCPLRQLILAGEGNTDSAVTVLGLMAGAAFAHNFGLASSGEGPTANGKIAVIIGIVVVAVIAAVNSMRKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HPX9</accession>
    <name>A0A174HPX9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">calB</name>
        <name evidence="9" type="ORF">ERS852478_03797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000050">
        <property type="protein sequence ID" value="CUO75140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201530.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75140">
        <property type="protein sequence ID" value="CUO75140"/>
        <property type="gene ID" value="ERS852478_03797"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="2"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 6">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO75140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="459" mass="51443" checksum="810DC2E190FB0DA8" modified="2016-09-07" version="1">MTETEIKEIVQKQRSYFYTGATLPVEKRLDALKKLKTCIQKYEPLINEALKRDLGKSNFESYMCEVGLVLSELSYMIRHTPSYAKEKTVLTPLAQFASRSYKKPSPYGVVLVMSPWNYPFLLTIDPLIDAIAAGNTVVLKPSAYSPHTSRVIETIITECFDPQYVAVVNGGRAENNTLLNEHFDYIFFTGSQHVGREVMAKASVHLTPVTLELGGKSPCIVEKSANLKLAARRIVFGKYLNCGQTCVAPDYIYCDREIKDELIRQIQKQIRKQFGSTPLNNKNYGKIINEKHFTRICNLIDPSKVACGGDNNPGALQIAPTVMDNVTFGDAVMQEEIFGPVLPVLAYDSLDEAIEKVNSMAHPLALYIFTSDKEAAEKVTSRCGFGGGCVNDTIIHLATSEMGFGGFGESGMGSYHGKDGFHTFSHYKSIVDKKTWLDLPMRYQPYRKIYEKLLRKFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HS34</accession>
    <name>A0A174HS34_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribose transport system permease protein rbsC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rbsC_7</name>
        <name evidence="7" type="ORF">ERS852478_03811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000052">
        <property type="protein sequence ID" value="CUO75655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060738.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75655">
        <property type="protein sequence ID" value="CUO75655"/>
        <property type="gene ID" value="ERS852478_03811"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO75655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="327" mass="34365" checksum="E25A33B25210A6C7" modified="2016-09-07" version="1">MKKESNGTTIVKNFMKSQGSVFIILLVMCIIASIFTDKFLSVSNLSNVLAQSVTCGIAAIGMTFVILTGGIDLSVGGCIVFSATIGTKLLSEGKVGVGTAIIIMLLLGVLVGVFNGFLITVLKMPAFIATLASSNVTAGLALYISMGKTIIGLPLEYSFIGLKKIAGVPFCVLLMICLYIVAYIVLKYTGYGRKVYATGSNRKSAWLSGINVRLIEFSVYVIQGVMSALVGVVLTSKLLTCTSTIGNGMEVNAIAAVVIGGASMSGGEGSIVGTIVGALILTIISNAMNLMSVNAYLQQVVMGLIIIMAILFDMVRKGYIFRKPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JFH2</accession>
    <name>A0A174JFH2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaerobic ribonucleoside-triphosphate reductase-activating protein</fullName>
            <ecNumber evidence="7">1.97.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BWLFYP14_00436</name>
        <name evidence="8" type="ORF">ERS852478_02016</name>
        <name evidence="9" type="ORF">ERS852523_00065</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
            <strain evidence="9 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO95870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2231"/>
    <dbReference type="EnsemblBacteria" id="CUO16300">
        <property type="protein sequence ID" value="CUO16300"/>
        <property type="gene ID" value="ERS852478_02016"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95870">
        <property type="protein sequence ID" value="CUO95870"/>
        <property type="gene ID" value="ERS852523_00065"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0602">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012837">
        <property type="entry name" value="NrdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352:SF2">
        <property type="entry name" value="PTHR30352:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000368">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00299">
        <property type="entry name" value="anaerobic_ribonucleoside-triph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02491">
        <property type="entry name" value="NrdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO16300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO95870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX62354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="152" mass="17210" checksum="35D98590F7818789" modified="2016-09-07" version="1">MLNGDGLRVVLWVAGCNHCCPECQNPVTWDPNGGLPFGEAERKEIFAELDKDYVSGITFSGGDPLHPANITEVTAFAKEIRKRYPGKTIWLYTGFLWEEICKEEIVRYLDVCVDGEFEVDKKELSLKWKGSSNQRVIDVPKTLHEGKVVLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K7D3</accession>
    <name>A0A174K7D3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn_dep_PLPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_02722</name>
        <name evidence="2" type="ORF">ERS852478_00226</name>
        <name evidence="3" type="ORF">ERS852523_00397</name>
        <name evidence="5" type="ORF">GT712_00335</name>
        <name evidence="4" type="ORF">GT728_05860</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN47067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000003">
        <property type="protein sequence ID" value="CUP05365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381034.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000017_gene246"/>
    <dbReference type="EnsemblBacteria" id="CUN47067">
        <property type="protein sequence ID" value="CUN47067"/>
        <property type="gene ID" value="ERS852478_00226"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05365">
        <property type="protein sequence ID" value="CUP05365"/>
        <property type="gene ID" value="ERS852523_00397"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030XIE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029002">
        <property type="entry name" value="PLPC/GPLD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00882">
        <property type="entry name" value="Zn_dep_PLPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="SSF48537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_dep_PLPC" evidence="1">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN47067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP05365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS87574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="196" mass="23072" checksum="6D81A6ADE06CFA6B" modified="2016-09-07" version="1">MRKKSHILLARYLADQMQTTASLQSHRKAFCLGSILPDIKPSFITRRHEFYGTFEDVKNRMKELADIRPDESNQRVYWRRFGEVIHYMADYFTFPHNKTYTGSFSQHNHYEKVLKNRLKECIQQGEAYAYLEPAIRFADFSTLIDYIEATHEKYLNKLRSVEEDIRFILNMCFQVVQGLIQICIGNKNFAGAIQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KYF3</accession>
    <name>A0A174KYF3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmB</name>
        <name evidence="9" type="ORF">BWLFYP14_00972</name>
        <name evidence="5" type="ORF">ERS852478_01506</name>
        <name evidence="6" type="ORF">ERS852523_00773</name>
        <name evidence="8" type="ORF">GT712_13020</name>
        <name evidence="7" type="ORF">GT728_11035</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP17052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000024">
        <property type="protein sequence ID" value="MZL33718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000026">
        <property type="protein sequence ID" value="MZS89967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019161496.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A174KYF3"/>
    <dbReference type="EnsemblBacteria" id="CUN96417">
        <property type="protein sequence ID" value="CUN96417"/>
        <property type="gene ID" value="ERS852478_01506"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17052">
        <property type="protein sequence ID" value="CUP17052"/>
        <property type="gene ID" value="ERS852523_00773"/>
    </dbReference>
    <dbReference type="GeneID" id="66492596"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN96417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP17052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS89967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX63486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="62" mass="6853" checksum="59FABC03E1B31DA6" modified="2016-09-07" version="1">MAKCAICEKAAHFGNNVSHSHRRSNKMWKSNVKSVKIKTAEGGARKTYVCTSCLRSGKVERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174N163</accession>
    <name>A0A174N163_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Peptide chain release factor 2</fullName>
            <shortName evidence="6">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">prfB</name>
        <name evidence="11" type="ORF">BWLFYP14_03584</name>
        <name evidence="9" type="ORF">ERS852478_02966</name>
        <name evidence="10" type="ORF">ERS852523_01485</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
            <strain evidence="10 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP39709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000028_gene197"/>
    <dbReference type="EnsemblBacteria" id="CUO48537">
        <property type="protein sequence ID" value="CUO48537"/>
        <property type="gene ID" value="ERS852478_02966"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP39709">
        <property type="protein sequence ID" value="CUP39709"/>
        <property type="gene ID" value="ERS852523_01485"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="8">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="6">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO48537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP39709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX67309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="329" mass="37518" checksum="42E723CC699EA0AA" modified="2016-09-07" version="1">MEAPDFWDDAEVSQKKMKELKDMKDDMETYQNLVTQMEDMETMIEMGYEENDPALIPEIQEMLDEFQKDFDNIRIKTLLSGEYDSENAIIKLNAGAGGTEACDWCGMLYRMYSRWADKKGFTLEVLDYLDGDEAGIKSVTFQVNGTNAYGYLKSEKGVHRLVRISPFNAAGKRQTSFVSCDVMPDIKKDLDVEINDDEIRIDTYRSSGAGGQHINKTSSAIRITHYPTGIVVQCQNERSQHMNKDKAMQMLKAKLYLLKQQEAEEKLSGIRGEVTDIGWGNQIRSYVMQPYTMVKDHRTNEETGNVDAVLDGGIDIFINAYLKWIALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NJC1</accession>
    <name>A0A174NJC1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">plsC_1</name>
        <name evidence="7" type="synonym">plsC_2</name>
        <name evidence="7" type="ORF">BWLFYP14_02874</name>
        <name evidence="4" type="ORF">ERS852478_02214</name>
        <name evidence="5" type="ORF">ERS852523_01684</name>
        <name evidence="6" type="ORF">GT728_11095</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">2789STDY5834863</strain>
            <strain evidence="5 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="2">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO23066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000015">
        <property type="protein sequence ID" value="CUP46065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000025">
        <property type="protein sequence ID" value="MZL33727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707970.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000021_gene1721"/>
    <dbReference type="EnsemblBacteria" id="CUO23066">
        <property type="protein sequence ID" value="CUO23066"/>
        <property type="gene ID" value="ERS852478_02214"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP46065">
        <property type="protein sequence ID" value="CUP46065"/>
        <property type="gene ID" value="ERS852523_01684"/>
    </dbReference>
    <dbReference type="GeneID" id="66493405"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="3">
        <location>
            <begin position="70"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO23066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP46065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL33727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="237" mass="27216" checksum="1AA454A8CD0066DA" modified="2016-09-07" version="1">MKRILLMVFRNLFFVPYGWFKLCWYASHAERYSEEQRYQLLKYVDNRAVKGGNLVIDGHGMENIPKENGFIFFPNHQGLFDVLAIIQVCPVPFSVVAKKELTNVPFLKQVFACMKAFMIDRDDVKQSMQVIINVIKEVKAGRNYLIFAEGTRSKDGNHPQEFKGGSFKAATKSKCPIVPVALIDSYKAFDTGSVKKLTVQVHFLEPIYYDEYKDMKTTEIAAEVKKRIEATITQYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174PVZ3</accession>
    <name>A0A174PVZ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cardiolipin synthase</fullName>
            <ecNumber evidence="3">2.7.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cls_3</name>
        <name evidence="2" type="synonym">cls_1</name>
        <name evidence="2" type="ORF">ERS852478_01709</name>
        <name evidence="3" type="ORF">ERS852523_02325</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000024">
        <property type="protein sequence ID" value="CUP65192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379960.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000018_gene66"/>
    <dbReference type="EnsemblBacteria" id="CUO05127">
        <property type="protein sequence ID" value="CUO05127"/>
        <property type="gene ID" value="ERS852478_01709"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP65192">
        <property type="protein sequence ID" value="CUP65192"/>
        <property type="gene ID" value="ERS852523_02325"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO05127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP65192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="466" mass="53329" checksum="68D8DF30BF6DF4A5" modified="2016-09-07" version="1">MKKILKRTGKIFCLFLLIVVLVNILSPLFCRKPDETYVESLRKTEFTSETAGVERICCIDDNEEALLWRLRMIGTAKESIVLSTFDLRADDNGTKILAALNCAAARGVKIQLLIDGIYQQLFLAGSSDFQALASYENVEVGVYNPVTPVNLFKVNYRMHDKYLIVDEKMYLLGGRNSNDIFLGDQTKGINEDRDILVYDTSEGQGESLNQLEDYFHKIWKESCVSIKNGKQSSRYTDAYRHMEEIYISLLKRYNDIETYSAWEKDTIEANKITLINNGIEAGRKTPQVLQTIQYLTENADHVIIQTPYVICNGYMYDVLQGISDHAKLQIVLNAVEKGSNPWGCTDYLNQKKKILETGADVYELMNDYPVHTKAVLINDRLSVVGSYNLDMRSTYLDTELMLVIDSEKLNQQIHETESDYMEKSKEVLANGQETEGAKYQGKVLNRKKKLYYGVLRIIIRPLRQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174TPW1</accession>
    <name>A0A174TPW1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">macB_8</name>
        <name evidence="5" type="synonym">macB_1</name>
        <name evidence="5" type="ORF">ERS852478_00260</name>
        <name evidence="6" type="ORF">ERS852523_04041</name>
        <name evidence="7" type="ORF">GT728_11990</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">2789STDY5834863</strain>
            <strain evidence="6 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000077">
        <property type="protein sequence ID" value="CUQ12143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000028">
        <property type="protein sequence ID" value="MZL33900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006426335.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49135">
        <property type="protein sequence ID" value="CUN49135"/>
        <property type="gene ID" value="ERS852478_00260"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ12143">
        <property type="protein sequence ID" value="CUQ12143"/>
        <property type="gene ID" value="ERS852523_04041"/>
    </dbReference>
    <dbReference type="GeneID" id="61849980"/>
    <dbReference type="GeneID" id="64016444"/>
    <dbReference type="GeneID" id="66493912"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN49135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUQ12143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="224" mass="24636" checksum="421953D3625EDD95" modified="2016-09-07" version="1">MSVILETKQLCKFYGAGENQVKAVNQVDIQIEQGEFVAIVGKSGSGKSTLLHMLGGLDTPTKGSVTLAGKDLYRMKEDALAVFRRRKIGFVFQAFNLVSSVNVWENIVLPLGLDGRKVDEAYVNDIIATLGIENRIYNLPNQLSGGQQQRVAIARALVNRPEIIFADEPTGNLDSKTSDEVIALLKMTAKKYGQTIVMITHDDEIAQVADRILVIEDGQVVDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WTS1</accession>
    <name>A0A173WTS1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="4">3.6.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mnmE_1</name>
        <name evidence="4" type="ORF">ERS852478_00059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199483.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN42510">
        <property type="protein sequence ID" value="CUN42510"/>
        <property type="gene ID" value="ERS852478_00059"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023873">
        <property type="entry name" value="FeFe-hyd_GTPase_HydF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041606">
        <property type="entry name" value="HydF_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040644">
        <property type="entry name" value="HydF_tetramer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18128">
        <property type="entry name" value="HydF_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18133">
        <property type="entry name" value="HydF_tetramer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03918">
        <property type="entry name" value="GTP_HydF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="16"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HydF_dimer" evidence="2">
        <location>
            <begin position="183"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="HydF_tetramer" evidence="3">
        <location>
            <begin position="285"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN42510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="402" mass="44971" checksum="54856B73898F99EB" modified="2016-09-07" version="1">MAVTLNETPSGNRLHIGIFGKTNSGKSSFINTFSGQKVSIVADVAGTTTDPVYKPMEIYPLGPCIIIDTAGFDDEGELGALRIEKTSLAAQKTELAIILFCEDEMVQELKWYNYFKKRQTPVIPVLGKADRYTQEQKEYLIQMIQKNTGETVCPVSSETGEGIRKLKELLAEKIPEGYGNRMITGNLVSKDDLVLLVMPQDIQAPKGRLILPQVQTLRELLDKRCLIMSVTTDRYPAALQTLSRPPKLIITDSQVFPYIYENKPKESMLTSFSVLFAAYKGDLSYYIEGAKAIDSLKETSHVLIAECCTHAPLKEDIGRVKIPRMLKKRFGENLQVELVSGTDFPDDLTGYDLIIQCGACMFNRKYVMYRIDRAKKQQVPVTNYGITIAHLTGILDHVALPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WUQ0</accession>
    <name>A0A173WUQ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN42277">
        <property type="protein sequence ID" value="CUN42277"/>
        <property type="gene ID" value="ERS852478_00052"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038690">
        <property type="entry name" value="NusG_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024045">
        <property type="entry name" value="NusG_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07009">
        <property type="entry name" value="NusG_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="NusG_II" evidence="2">
        <location>
            <begin position="12"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN42277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="123" mass="13447" checksum="D039E29D16F28E9B" modified="2016-09-07" version="1">MKKKEFIFIGGILILALAMWGGMFLINKGSHGSIRITVDGKEYGTYSLAKDQTIKINDTNVCEIKDGQARMISAQCPDHLCMKQKAIDEKGGTIVCLPNKVVIEGEKSTDSKKTDEPVIDAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X382</accession>
    <name>A0A173X382_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PrsW family intramembrane metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02648</name>
        <name evidence="2" type="ORF">ERS852478_00150</name>
        <name evidence="3" type="ORF">GT712_00705</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993918.1">
        <property type="nucleotide sequence ID" value="NZ_WWVG01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45015">
        <property type="protein sequence ID" value="CUN45015"/>
        <property type="gene ID" value="ERS852478_00150"/>
    </dbReference>
    <dbReference type="GeneID" id="66495873"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN45015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS87646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="207" mass="22744" checksum="A0E1419E463B01E7" modified="2016-09-07" version="1">MTYIENVFLCIASPLLIAALCMGKRQRKFFLFCLAGMGACLLSAYINTFFAALYRADTFTTTTEIAPVVEEVMKFLPLLFYLLIFEPKREQIKNTAVVIALSFATFENVCYLIQNGAGHFSFIFFRGIGTGAMHVICGAIVGGGLAYVWQRTWLKIAGTCGLLGAAITFHAIYNLLIAYGSAAQYIAYLLPVLILAAGKLIFRSSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X475</accession>
    <name>A0A173X475_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YihY family inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yihY</name>
        <name evidence="6" type="ORF">BWLFYP14_02672</name>
        <name evidence="4" type="ORF">ERS852478_00174</name>
        <name evidence="5" type="ORF">GT728_06120</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703238.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45627">
        <property type="protein sequence ID" value="CUN45627"/>
        <property type="gene ID" value="ERS852478_00174"/>
    </dbReference>
    <dbReference type="GeneID" id="66495849"/>
    <dbReference type="eggNOG" id="COG1295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN45627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL32792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="298" mass="33780" checksum="17B99A7C0B23DF7B" modified="2016-09-07" version="1">MKKKNKTRSVTGLLFGFMERVSGDHVGAYATQAAYFLIMSFIPCILFLTTLVRYTPLTYNVVRDAIVAFIPENLQSFVLGIVVDVYKRSTAIVPLSAIVALWSAGKGMQSIINGLNTIYHVKETRNWLLTRIYAVFYTLSLVIAVIVSLLMLVLGNEIQKVVSRYIPFLGRVLGKILGARALLVFGVLFLVFLMLYKVLPNRKATFKSQIPGALIIAVAWSIFSYGFSFYFEIFPGFSNMYGNLATIIMVMVWLYICMNLLLYGAEINAYFEKEFRIAHKSVQELLAHEKEKKQQENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X5Y1</accession>
    <name>A0A173X5Y1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="3">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">leuA</name>
        <name evidence="6" type="ORF">BWLFYP14_02679</name>
        <name evidence="5" type="ORF">ERS852478_00182</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45818">
        <property type="protein sequence ID" value="CUN45818"/>
        <property type="gene ID" value="ERS852478_00182"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN45818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="551" mass="61617" checksum="2CF16F1B1554978A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X765</accession>
    <name>A0A173X765_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF362 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Domain of uncharacterized function (DUF362)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00241</name>
        <name evidence="3" type="ORF">GT728_15000</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN47483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000041">
        <property type="protein sequence ID" value="MZL34471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199516.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN47483">
        <property type="protein sequence ID" value="CUN47483"/>
        <property type="gene ID" value="ERS852478_00241"/>
    </dbReference>
    <dbReference type="GeneID" id="66495781"/>
    <dbReference type="eggNOG" id="COG2006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF362" evidence="1">
        <location>
            <begin position="38"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN47483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="366" mass="40899" checksum="EE3176AEEE028F06" modified="2016-09-07" version="1">MNKNEIYIKSGTNYKEMTKELLAQCGLASVISDKKMQIGIKPNLVSPSEASWGATTHPEIVAGIIEYLQENGYGNIAILEGSWVGDKTTEAYEVCGYRELTEKYQVPFWDMQKDKGIERDCRGMKLNVCERAANIDFLINVPVLKGHCQTKITCALKNMKGLIPNTEKRHFHAMGLHEPIAHLNAGLHQDFVVVDNICGDLDFEDGGNPVVMNRIWAGTDPVLIDSYVCQIMHYTTKDVPYIELAEKLGVGSTDLKNSHIVYCEENARKELPKSRKVVELQDAVEEVESCSACYGYLIPALEMLKNDGLFEKLDTKICIGQGYRGKTGKLGVGACTCKFEHNVKGCPPTENQIYDFLKQYILGENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XDN6</accession>
    <name>A0A173XDN6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted AAA-ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199543.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIOY010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49773">
        <property type="protein sequence ID" value="CUN49773"/>
        <property type="gene ID" value="ERS852478_00281"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018631">
        <property type="entry name" value="AAA-ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012547">
        <property type="entry name" value="PDDEXK_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09820">
        <property type="entry name" value="AAA-ATPase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08011">
        <property type="entry name" value="PDDEXK_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA-ATPase_like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN49773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="562" mass="65620" checksum="2CA3A3822B3647E7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XFU9</accession>
    <name>A0A173XFU9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">mRNA interferase YafQ</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yafQ_2</name>
        <name evidence="3" type="ORF">ERS852478_00264</name>
        <name evidence="4" type="ORF">GT712_15855</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000040">
        <property type="protein sequence ID" value="MZS90500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199533.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49258">
        <property type="protein sequence ID" value="CUN49258"/>
        <property type="gene ID" value="ERS852478_00264"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004386">
        <property type="entry name" value="Toxin_YafQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40588">
        <property type="entry name" value="PTHR40588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15738">
        <property type="entry name" value="YafQ_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006156">
        <property type="entry name" value="YafQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00053">
        <property type="entry name" value="TIGR00053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN49258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="93" mass="10866" checksum="77FC1090127D4BED" modified="2016-09-07" version="1">MKYDIQFTNQFKKDLKLAKKQNKNLDKLFEVIGILANGGTLDAKYRDHDLTGNYKGTRECHIEPDWLLIYEICGDVLVLMLYRLGSHSELFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XKE8</accession>
    <name>A0A173XKE8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ben and cat operon transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">benM</name>
        <name evidence="2" type="ORF">ERS852478_00338</name>
        <name evidence="3" type="ORF">GT712_05865</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000009">
        <property type="protein sequence ID" value="MZS88625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199574.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51496">
        <property type="protein sequence ID" value="CUN51496"/>
        <property type="gene ID" value="ERS852478_00338"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN51496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS88625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="302" mass="34883" checksum="0F14010EF6F48355" modified="2016-09-07" version="1">MDLKQLQYFVVCAQTGSFSDAAKNLYSTQPSVSKVIKGLEDTLGMQLFERLPRGIRLTVQGHKIYEYASKIINEVNVLENMASSGMTKWIRISLNPSSWFANQFVDFYNETYEKKYHFQVTTAGVQSVMERVRDYMDDIGFVYILSQQKENFLYELSKNKMYFEPIYETDVMLYPGRLTELYNSGKERAELEDLEGIRFIQNYQDEFFDIGAVKEDAFQWKDIDISVLTNSDYIMEKMLKNSKVANISGSYLSENKEGTTPGIPLDLGDSKVIFGFILHKGEEMDESVAELVEFLKSRLPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XTH9</accession>
    <name>A0A173XTH9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+-dependent transporters of the SNF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_00428</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199617.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54256">
        <property type="protein sequence ID" value="CUN54256"/>
        <property type="gene ID" value="ERS852478_00428"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN54256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="444" mass="49016" checksum="63CB1FDD0B410EFA" modified="2016-09-07" version="1">MKREQLGSRLGFIMLSAGCAIGCGNVWKFPWMCGQNGGGSFMLIYLLCLVILGIPALVLEFSIGRAAQTSPLFMYRKLEKPGQKWGIFGWFCLLGNIALMAFYTVVCGWIIYYFVQFLRGKNGSLGFSAMISSPSVNVFFLLVTVVIAFFILSFNLQGGLERVTKYMMSALLVLMLALAVHSLFLKGAGEGMTFYLKPDFSKIDGSVIVGAMNQAFFTLSTGMGGMAIFGSYIGKEHSLMGEAIHVITLDTLVAFLAGVIIFPACFTFNLEVNAGPSLLFDTMAAVFNNMSGGRIWGSLFFLFMVFAAMSTVLGVCENILAMIRELTGWSRPKGSVVCGTGVFLLALTTALGFSVFHFQPFAEGTTWLDFWDFIVSNNILPLGSLILALFCCNKFGWGWDNFIKESNTGKGLKVQSWMKPLFRFVLPIMIAFIYIYGMFTFNWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y1E9</accession>
    <name>A0A173Y1E9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional protein GlmU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glmU_1</name>
        <name evidence="3" type="ORF">ERS852478_00486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199669.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56967">
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        <property type="gene ID" value="ERS852478_00486"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2068">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="2">
        <location>
            <begin position="5"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lysR-type" evidence="1">
        <location>
            <begin position="219"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN56967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="309" mass="34557" checksum="9E9DC1D8F589A7EB" modified="2016-09-07" version="1">MQTGALIVAAGKSSRMGDFKPMLQLGSISIAQRVINNFRQAGISKVVVVTGYHADVLECHLASNNVVFLRNENYANTHMFDSVRIGLEYLKDKVDTVLFTPVDVPLFTAHTVTQMLSLGRPLVTPVCNGNPGHPILIRSTLIDSILSDDGKSGLKGAVDNCGEPMYYLNVEDPGIIHDADTPEDYDELLRIHNQSLIRSEIHIQLAREKVFFDEKLYSLLTLIHETGSVRDACERMHISYSTSWNLIHTLESQLHEPLIIRSQGGTRGSHSELTPYGEEFLKRYARFSEETRSCSKKIFEECFGGFLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y1Y0</accession>
    <name>A0A173Y1Y0_9FIRM</name>
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        <submittedName>
            <fullName evidence="3">DUF4867 family protein</fullName>
        </submittedName>
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    <gene>
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        <name evidence="2" type="ORF">ERS852523_01368</name>
        <name evidence="4" type="ORF">GT712_12485</name>
        <name evidence="3" type="ORF">GT728_11450</name>
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    <organism evidence="1 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000011">
        <property type="protein sequence ID" value="CUP36027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000026">
        <property type="protein sequence ID" value="MZL33795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000024">
        <property type="protein sequence ID" value="MZS89863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708127.1">
        <property type="nucleotide sequence ID" value="NZ_JADPEU010000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000030_gene3610"/>
    <dbReference type="EnsemblBacteria" id="CUN57570">
        <property type="protein sequence ID" value="CUN57570"/>
        <property type="gene ID" value="ERS852478_00504"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP36027">
        <property type="protein sequence ID" value="CUP36027"/>
        <property type="gene ID" value="ERS852523_01368"/>
    </dbReference>
    <dbReference type="GeneID" id="66492744"/>
    <dbReference type="eggNOG" id="ENOG502ZCEZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032358">
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        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN57570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP36027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="205" mass="22254" checksum="BF72D451BBEB68D3" modified="2016-09-07" version="1">MKIQNVTDASFRKYGKVLEGYDFSALLKEMKHTPVPDDVVYVPSVEELEALDVAKALQNKGFGGIPIEIGYCNGHNKKLNAVEYHRSSEINVAVTDLVLLIGSQQDITDDFTYDTSKIEAFLVPAGTGIEVYATTLHYAPCNVQDGGFQCVVVLPAGTNTDLTFETAKTGEDSLLTAKNKWLIAHEDAAIEGAVNGLRGENITID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y876</accession>
    <name>A0A173Y876_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type transport system involved in multi-copper enzyme maturation, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199703.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58918">
        <property type="protein sequence ID" value="CUN58918"/>
        <property type="gene ID" value="ERS852478_00548"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032JNS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN58918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="258" mass="29802" checksum="84D017D77F2CE713" modified="2016-09-07" version="1">MKNIIKTDFKRALKGAKFPLAIILMFFVWEFNSKRFADSQDVLYLFVHVWGRSITPLLAMIVTSTVYVTSYCEDTENHFLRYSIQRVGIRKYVISKIIVVFCTSFLVVILGSIIFVIWQCHELPVVSSDSITVENFKSESCFGWLLPENTELYMGVQIFLDGLYCASMSVLSLALSTFVRDSYAVYAFPFLLNYFFIFLFSRIAVKYPMLYMEEIYNSATKTYTDDPVLLIAYALFVTVVFLGISGMIMLKKIEGEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YA60</accession>
    <name>A0A173YA60_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable molybdenum cofactor guanylyltransferase</fullName>
            <shortName evidence="4">MoCo guanylyltransferase</shortName>
            <ecNumber evidence="4">2.7.7.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GTP:molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Mo-MPT guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin-guanine dinucleotide synthase</fullName>
            <shortName evidence="4">MGD synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mobA_1</name>
        <name evidence="4" type="synonym">mobA</name>
        <name evidence="6" type="ORF">ERS852478_00583</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide</text>
            <dbReference type="Rhea" id="RHEA:34243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:71310"/>
            <dbReference type="EC" id="2.7.7.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MobA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.77" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053030.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60036">
        <property type="protein sequence ID" value="CUN60036"/>
        <property type="gene ID" value="ERS852478_00583"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061603">
        <property type="term" value="F:molybdenum cofactor guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00316">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="5">
        <location>
            <begin position="9"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN60036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="206" mass="23026" checksum="EC62964C39843C87" modified="2016-09-07" version="1">MRKKEISMIILAGGASSRMGRDKSDLTIDGKTFLEMQIEKGKKLGISDILLSGYHGENKYKYPIIPDRFPGKGPLGGLEACFRKAKNPYCLVLGVDVPLVPAEELAALIRQSLHSDAKAVILSHGGHEEPLMGVYCTDLADAMLEEITERKGAVFAFLRKNGYECYESQAAAWYFSNINDSETYKEIAGNHFRFNWKTVMRVDRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YJ38</accession>
    <name>A0A173YJ38_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">23S rRNA (Uracil-C(5))-methyltransferase RlmCD</fullName>
            <ecNumber evidence="7">2.1.1.189</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rlmCD_1</name>
        <name evidence="7" type="ORF">ERS852478_00656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.189" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN63580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199744.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63580">
        <property type="protein sequence ID" value="CUN63580"/>
        <property type="gene ID" value="ERS852478_00656"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN63580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="546" mass="61489" checksum="F9916ABF1D7AD184" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YMY5</accession>
    <name>A0A173YMY5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thermostable beta-glucosidase B</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bglB_2</name>
        <name evidence="4" type="ORF">ERS852478_00716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199772.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65511">
        <property type="protein sequence ID" value="CUN65511"/>
        <property type="gene ID" value="ERS852478_00716"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="923"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="Fn3_like" evidence="3">
        <location>
            <begin position="442"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN65511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="953" mass="104936" checksum="8FDF78BDAE5CE23C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YNE7</accession>
    <name>A0A173YNE7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitric oxide reductase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199774.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65652">
        <property type="protein sequence ID" value="CUN65652"/>
        <property type="gene ID" value="ERS852478_00721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025861">
        <property type="entry name" value="CobT_VWA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11775">
        <property type="entry name" value="CobT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobT_C" evidence="1">
        <location>
            <begin position="402"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="CobT_C" evidence="1">
        <location>
            <begin position="486"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN65652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="605" mass="70468" checksum="BA9C461DE678CA63" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YPZ2</accession>
    <name>A0A173YPZ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ftsW_1</name>
        <name evidence="7" type="ORF">ERS852478_00704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199767.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65155">
        <property type="protein sequence ID" value="CUN65155"/>
        <property type="gene ID" value="ERS852478_00704"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN65155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="365" mass="39507" checksum="62EB9CDC697A2272" modified="2016-09-07" version="1">MARKRATDLSKTDMTMLVLIVLLVIFGLAVLFSSSEYNGRVRFGDSACYFKKQLFATALGMGVMYMVSSIDYHFFLRLGPVAYLISMFLSGAVLFVGQEINGSKRWLNLGPLSFQPSEFAKVAVILFLAWQIERTKKATRGFGFMCRTILTLLPIIGLVGSNNLSTAIIILGIGGILIFVSNPGYLEFIGLGSAGAGFIAVFLAAESYRLERLAIWRNPEKYEKGFQTIQGLYAIGSGGIFGRGFGNSLQKLGFVPEAQNDMIFSIICEEMGAAGAIFLIFLFAMLLWRLGVAAMHAKDLAGALICCGIMGHLALQVILNIAVVTNTIPNTGITLPFISYGGTSAVFLLGEMGLAMNVGKCDRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YQQ2</accession>
    <name>A0A173YQQ2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine diphosphokinase</fullName>
            <ecNumber evidence="1">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">thiN</name>
        <name evidence="7" type="ORF">ERS852478_00727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.6.2" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199780.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIOU010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65910">
        <property type="protein sequence ID" value="CUN65910"/>
        <property type="gene ID" value="ERS852478_00727"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="SSF63862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPK_B1_binding" evidence="6">
        <location>
            <begin position="170"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN65910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="243" mass="27104" checksum="83B570615AA26D48" modified="2016-09-07" version="1">MIDTIIVSGGNIHSDFALDFLKKNEACLIAADKGLEFFLEHQLLPDAVIGDFDSLSEDGKKFLEIQEEKSMDSEIPYGGMTEWKVQKGFRNEIKEIKVIRLRPEKDDSDTQSAMNYAIRTGAKEIVIFGVTGNRVDHLMANFGLLVLAQNQGAEVTLVDQYNYMKLISDGTVLKKSEQFGKYVSFFPFGGNVTDLTLEGFKYPLSNYCLTAADSGLTVSNEIISEYARVTFSSGELLMIMSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z7U6</accession>
    <name>A0A173Z7U6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease TTHA0252</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199833.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71967">
        <property type="protein sequence ID" value="CUN71967"/>
        <property type="gene ID" value="ERS852478_00880"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="250"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN71967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="538" mass="59888" checksum="9157671FC189AFBB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZD74</accession>
    <name>A0A173ZD74_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF based on E. rectale Gene description</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
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    </dbReference>
    <dbReference type="RefSeq" id="WP_055059456.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73743">
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        <property type="gene ID" value="ERS852478_00939"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024538">
        <property type="entry name" value="DUF3878"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12994">
        <property type="entry name" value="DUF3878"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN73743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="327" mass="38445" checksum="F5C0BCD6808DBCE5" modified="2016-09-07" version="1">MEDIMEDNFEKLNLLLEQEQCEFVDIPDSFTGQTESGELRLIYLMNDAVESFLILKNARMTGNYVRDYEGEFEGSIEKADRDLCEAEYILVIHQGQNVFTVFFEDILLETQLYNYGELGHFWVKGYENLRVMEYQIAILRDKYEYLGEKYCTEYEGKLAMLRDFPPLNYLFYPAVPEKYIVPVDNPWEVTAEALAVMQELATEAGDEKLGKMLRRYEKNSDISNAKKIAGMLCRSSHLPVITLLGEKIREAASVYPDRDFGRKQNKYLHELMEKAERRKEELEAENVQTLIYREEPFIYDCDSISFQVYLMIVRKGVWKQKIMVEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZDS0</accession>
    <name>A0A173ZDS0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydro-rel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199847.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73275">
        <property type="protein sequence ID" value="CUN73275"/>
        <property type="gene ID" value="ERS852478_00924"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
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    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="100"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN73275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="292" mass="32205" checksum="00CE7DB3E2DF7245" modified="2016-09-07" version="1">MFGECHAHIIMDGVNYRHAIDMHKNGPDDKIIREHLKAYQERGIVFVRDGGDALGVSARAKELAPEYGIDYRTPIFAIHKEGHYGSIVGKGFATMVEFHKRVLEAKQAGADFIKIMTTGILDFNEHGAITGTPLDGSEVKEMVHIAHEEGMAVMSHTNGDYGVQAAVAAGVDSLEHGNYMNEESLAMLAESDTVWVPTLITVRNLLGDGRYDDETLKPIIESAEENIRKAFRLGIKTAPGSDAGAYRVLHGKGIRDEVQSFVEILGDQDAAYRWLAEGEAEIKKKFTVTVHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZH94</accession>
    <name>A0A173ZH94_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane dipeptidase (Peptidase family M19)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74495">
        <property type="protein sequence ID" value="CUN74495"/>
        <property type="gene ID" value="ERS852478_00964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN74495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="309" mass="35381" checksum="92ABAE8AC35D359C" modified="2016-09-07" version="1">MNYFDCHVDTLTEILKPGDTLDENSCNLDLKRVGNFVENYTQIFAIWKDAVKLDKEEPDRDFFRLYDRAMAYLAEENRKIALCLTGEEMEKAHRQRKAAAFLSIEDLSIMGKYVEKIREMGFRFAMLTWNYENEYACGAAADQAKGLTARGKEMVKVLTDQGIVMDISHLSDQGVEDLFQLTDRPVMASHSDIREVWDAPRNLQKVHLKELISRKGIIGMNFFAPFVGEKPQISDLLKHMDAVLEMGGEDCLAIGSDFDGCDGLFPAHIEGVQSMPFLREELLKHGFTEELTEKIFYKNAHRFVMENVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZI08</accession>
    <name>A0A173ZI08_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anaerobic benzoate catabolism transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707119.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75874">
        <property type="protein sequence ID" value="CUN75874"/>
        <property type="gene ID" value="ERS852478_01004"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN75874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="105" mass="11948" checksum="F2337E47551ED041" modified="2016-09-07" version="1">METENYGSLIKNLRQKMGLTQNQVADSLGVTPGYISNVENNRTAMSLRILTYYARLTGCSLDSLVGELDPEYSETAIDRKLYQNIIKLDVETKEKLLKTLEIWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZWA3</accession>
    <name>A0A173ZWA3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Int-Tn_2</name>
        <name evidence="4" type="ORF">ERS852478_01088</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79686">
        <property type="protein sequence ID" value="CUN79686"/>
        <property type="gene ID" value="ERS852478_01088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN79686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="200" mass="22814" checksum="6754D589586CBBA2" modified="2016-09-07" version="1">MIGTGLRVGEVTGLRWCDIDMESGMIDVNHTLVYYDHRTEGSKSGCYFNVNTTKTPASMRQVPMLGFVKEAFEHEKQKQEDLGLHCEVTIDGYTDFIFINRFGQAQHQATLNKAIRRIIRDCNDEQFLHSDEPDVLLPHFSCHSLRHTFTTRMCEAGVNIKVIQDALGHSDISTTLNIYADVTKEMKAEEFKGLDSYFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A006</accession>
    <name>A0A174A006_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81992">
        <property type="protein sequence ID" value="CUN81992"/>
        <property type="gene ID" value="ERS852478_01152"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3854">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014217">
        <property type="entry name" value="Spore_III_AA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045735">
        <property type="entry name" value="Spore_III_AA_AAA+_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19568">
        <property type="entry name" value="Spore_III_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02858">
        <property type="entry name" value="spore_III_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spore_III_AA" evidence="3">
        <location>
            <begin position="15"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN81992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="321" mass="36191" checksum="4C2ACA222D6CEF82" modified="2016-09-07" version="1">MSTYIKCKEVRHIEAQQIENLFAGNIRNLLMDAKLDYDKLYEIRLRVGRPLFLTYDGGECFLRKPGQKQYLVTTEDLKETLEYVTGYSLYAYEDEIRQGFISVQGGHRVGVTGKVVLDRGRIMGMKYISCINVRLAHEIQGCADKVMPYIRTEKWVANTLIISPPRCGKTTLLRDIIRQLSNGWANTQGLTIGVVDERSELAGCYQGIPQNDLGMRTDVLDCCPKSEGMQMLVRSMSPDVVAVDELGCEEDFKAVDSVIHCGCKLIATAHGSCLEDVLDQPFFYKLMGEKVFERYIILDKNDQAGCLKAVLDENGKVCLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A2H0</accession>
    <name>A0A174A2H0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein AE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoIIIAE</name>
        <name evidence="2" type="ORF">ERS852478_01156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199942.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82089">
        <property type="protein sequence ID" value="CUN82089"/>
        <property type="gene ID" value="ERS852478_01156"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7PW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014194">
        <property type="entry name" value="Spore_III_AE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09546">
        <property type="entry name" value="Spore_III_AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN82089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="409" mass="44992" checksum="F85DE8778FA05410" modified="2016-09-07" version="1">MRQDKERSIREQADLWKGYWCILACILLVGRVSYLTFFQNHIVSVYAAAQTEQKEDSSVQILQENLMEEIQIDDVQKMLDEIMDDHVFSVREALMNIINGEEPVSKETVRSFLYSLFFSDIENEKGLILKLLLVIFIAAVLAEFADVFGNGQAGSISFYIVYLALFTMLMENFSRLGSTLTNWLLGLTDFMKVLSPAYFMTVAASTGSSTAAAFYEGILLMIWAVQWLLANLFLPAVNLSLLLKMVNYLSKEEMLTKMAELLDIAVNWGLKTLLGAIVGLQIVRNMVSPVMDAMKRSAVGKAASAIPGIGNAVTAVTELVLTSAVMVRNSFGAVIVIFLLLIGAGPIIHYGSLSLVYRFLAAIAQPISDKRVVGALSTMGEGCAMLLKLLLTAEVLCMLTFLIVVVSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A488</accession>
    <name>A0A174A488_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01194</name>
        <name evidence="4" type="ORF">GT712_03730</name>
        <name evidence="3" type="ORF">GT728_00225</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026648433.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83431">
        <property type="protein sequence ID" value="CUN83431"/>
        <property type="gene ID" value="ERS852478_01194"/>
    </dbReference>
    <dbReference type="GeneID" id="66494029"/>
    <dbReference type="eggNOG" id="COG3655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN83431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL31658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="73" mass="8662" checksum="D8F0BAEF87DAF24B" modified="2016-09-07" version="1">MISYRKLWKTMKERKISQYALYTHYGISTSFLDKLRHNENVEIRSLDILCSILDCDFGDIVEHIPDNAEPEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A779</accession>
    <name>A0A174A779_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">ribH</name>
        <name evidence="12" type="ORF">BWLFYP14_03011</name>
        <name evidence="8" type="ORF">ERS852478_01224</name>
        <name evidence="9" type="ORF">ERS852523_00543</name>
        <name evidence="11" type="ORF">GT712_03875</name>
        <name evidence="10" type="ORF">GT728_00080</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN84562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP09545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994061.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000043_gene3364"/>
    <dbReference type="EnsemblBacteria" id="CUN84562">
        <property type="protein sequence ID" value="CUN84562"/>
        <property type="gene ID" value="ERS852478_01224"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP09545">
        <property type="protein sequence ID" value="CUP09545"/>
        <property type="gene ID" value="ERS852523_00543"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0054">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="85"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN84562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP09545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL31629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS88252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX66735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="155" mass="16558" checksum="1E1D916982475D1D" modified="2016-09-07" version="1">MKTLEGKLVSDGMKVGIVAARFNEFITSKLVSGAMDGLTRHNVKEEDIQVAWVPGAFEIPLIASKMAKSGKYDAVICVGAVIRGNTSHYDYVCNEVSKGIASVSLETGVPVLFGVLTTENIEQAIERAGTKAGNKGYDCALSAIEMVNLIKEFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ACJ5</accession>
    <name>A0A174ACJ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PrgI family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199980.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86134">
        <property type="protein sequence ID" value="CUN86134"/>
        <property type="gene ID" value="ERS852478_01238"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024414">
        <property type="entry name" value="Uncharacterised_PrgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12666">
        <property type="entry name" value="PrgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN86134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="150" mass="17373" checksum="87F7F5FAF311DF42" modified="2016-09-07" version="1">MEVKINKEIRNYTESMFFGLSLRQFIFSVLACGVAVGLYFLLRPRFGTETLSWVCILGAFPFAAMGFIKYNGMTAEQFVWAWIKSEFLMPKKLMFLPDNLYYETMKPTIEAYEKGLATVRKKQKGRTPKPKKTKKKKAKRSKEVNNAENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AE49</accession>
    <name>A0A174AE49_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maff2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01259</name>
        <name evidence="3" type="ORF">GT728_16835</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000053">
        <property type="protein sequence ID" value="MZL34811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002586628.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86941">
        <property type="protein sequence ID" value="CUN86941"/>
        <property type="gene ID" value="ERS852478_01259"/>
    </dbReference>
    <dbReference type="GeneID" id="61666910"/>
    <dbReference type="GeneID" id="63969200"/>
    <dbReference type="eggNOG" id="ENOG5032RXK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024272">
        <property type="entry name" value="MAFF-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12750">
        <property type="entry name" value="Maff2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN86941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="46" mass="4773" checksum="292B69966BBE6958" modified="2016-09-07" version="1">MAFFNSAVDVLQTLVVALGAGLGIWGVINLMEGYGNDNPGANAHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AZ68</accession>
    <name>A0A174AZ68_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN92800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200055.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN92800">
        <property type="protein sequence ID" value="CUN92800"/>
        <property type="gene ID" value="ERS852478_01397"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN92800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="118" mass="14115" checksum="6B8917267A415722" modified="2016-09-07" version="1">MDVRKVQDMRKNVEHQYITEDSKTRIYLSVVREFNEKEYEKYSQKKKRAKMKKRIRFLKRLMVYIIPTAISLIFFGYLSDMLCAIRGSAELGSEWIAIPIMWVWIHALVRFAVGDDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B214</accession>
    <name>A0A174B214_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anaerobic sulfatase-maturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_01462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200105.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94867">
        <property type="protein sequence ID" value="CUN94867"/>
        <property type="gene ID" value="ERS852478_01462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026412">
        <property type="entry name" value="rSAM_Cxxx_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01384">
        <property type="entry name" value="thioether_bond_formation_requi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04115">
        <property type="entry name" value="rSAM_Cxxx_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN94867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="437" mass="50336" checksum="DEDDD78E132FA391" modified="2016-09-07" version="1">MKRTEQYSERLSRLYPELHEPVGTEKILTQTVTFQVTDDCNLACKYCYQTHKGKKKMSFETAKKMVDLLLSGNKGVGDYINPQKSPGLIIDFIGGEPLLEIELIDQICSYTINRMIELNHPWLTRTMFSICSNGVCYFEPEVQRVLQKWNQRLSFSVTVDGNKELHDSCRVFPDGQPSYDLAISAAKDWVNKGGYMGSKVTIAPANVMHVYDAITHMINLGYNEINANCVYEEGWQMIHATVFYDQLKKLADYILEHNLDMENDYYISLFEENFFHPKQPDDLENWCGGNGVMLAVDPDGIIYPCLRYMESSLAGQQEPYSIGDVDTGICQTECDRCRVECLKKIDRRTQSTDECFNCPVAEGCSWCTAYNYQVFGTPDARATYICDMHKARALGNIYFWNHYYEKNNIDKHMENHVPEEWALNIISKPEWDMLCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BI52</accession>
    <name>A0A174BI52_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase DpiB</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dpiB</name>
        <name evidence="3" type="ORF">ERS852478_01603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057315.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00672">
        <property type="protein sequence ID" value="CUO00672"/>
        <property type="gene ID" value="ERS852478_01603"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="2">
        <location>
            <begin position="325"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO00672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="431" mass="49686" checksum="80714A0E64C6FEF1" modified="2016-09-07" version="1">MIVRDFLICLLQMYLLEDLEKNMLPYRRENFWGKFLVYFVVALIMLGINHLESSIFNMVMIPVTYMIVSMVVFRGNIWKKLVIVCCYYVLAIIPEFLFATLTNAYGVTGASEGFGTEIEKTLALLLMSTMTFLFIKCINQVTRKRDYLTIENKTFTVLLMLPTATIIILGCVFYSNISFEGMNRVMVPVGASLLLLTNIFIFSVFDRFVEKSEEVKKMDRLYQKSRAEIANLQYMNKVNEDNRAFLHDINKFICTVAGLMEEGENQEVKEIMEHLGVRIQSLQKGVYCEHPILNSILCERKFLAESKNISYKITLGNDLRLDFLEELDMISIVGNLLDNALEAAEKTKDGRYVECRMYMGNEEHFLVMEFCNGYVVPLLKDKDRYISTKRDADSHGIGLHTVGKLVKKYAGIMRVEAGEREFSVKLIFTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BKF9</accession>
    <name>A0A174BKF9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Replication initiator protein A (RepA) N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057303.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00078">
        <property type="protein sequence ID" value="CUO00078"/>
        <property type="gene ID" value="ERS852478_01585"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010724">
        <property type="entry name" value="RepA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06970">
        <property type="entry name" value="RepA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RepA_N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO00078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="272" mass="31776" checksum="95127F04D02F14CC" modified="2016-09-07" version="1">MADFEYFRAEESDQFSFFRIPKALFTEKEFQSLSTDAKLLYGILLDRISLSKKNGWIDSDGYVYIIYTIAELQDLLRMSHTTVTKLLYELDSVHGIGLIERYRQGNNRPSVIYVKNFVKRVRGKPDRYFHSGLQETGSPDSKELEIRIARNWKSGQQKNRSPDCKNLEGSNTKINKTEKNHTDKSKSNTHALEENFSQYGRFKNVVLSEPELQELMTLFPWDYQKRIDHLSVYMKSSGKEYQNHFATICLWAERDGARAGMDKYEFQEGESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BP00</accession>
    <name>A0A174BP00_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative HMP/thiamine import ATP-binding protein YkoD</fullName>
            <ecNumber evidence="8">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ykoD</name>
        <name evidence="8" type="ORF">ERS852478_01618</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057327.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01328">
        <property type="protein sequence ID" value="CUO01328"/>
        <property type="gene ID" value="ERS852478_01618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="272"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="305"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO01328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="504" mass="56043" checksum="B8BEC7D986CCFBBA" modified="2016-09-07" version="1">MIECQNVSFSYPASGIPGNDTQTGGALQNISCTIEDGSFVLLCGPSGCGKTTMTRLLNGLIPHYHEGNFTGSVRLDGKDTRELSLFDISLKVGSVFQNPRSQFFNVDTTSELAFGPENHGMPEEIVRERVNRVAGQLKLEPLLDRSIFSLSGGEKQKIACGSAAAVDPRIYVLDEPSSNLDTYAISDFRQLLSILKAQGKTIIISEHRLYYLSGLFDRVLYLKDGEIQGDYSAKEFTGLSAKQRDEMGLRPLSLDGLKEITGPVSHRSDSSWMLSNISFSYKHEPEILHIPEAVFPVGKATAVIGHNGAGKSTLSRCLCGLEKRCRGLVQDQERAYSQKERLRLCYMVMQDVNHQLFTESVLDEILLSMRDEDKEKAEQILDGMDLLPYKDCHPMSLSGGQKQRVAVASAITSERPLVLFDEPTSGLDLLHMRQVAKVVNQVTDTGRTAVVVTHDPEFILRCCEFVLHLENGQVQESYSIEDSDGRNRLLKFFLNDMEKEVSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C0D5</accession>
    <name>A0A174C0D5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP synthase subunit F</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">V-type ATP synthase subunit F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BWLFYP14_01152</name>
        <name evidence="4" type="ORF">ERS852478_01716</name>
        <name evidence="5" type="ORF">ERS852523_02332</name>
        <name evidence="7" type="ORF">GT712_12270</name>
        <name evidence="6" type="ORF">GT728_09920</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">2789STDY5834863</strain>
            <strain evidence="5 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 13">BIOML-A1</strain>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000024">
        <property type="protein sequence ID" value="CUP65326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000020">
        <property type="protein sequence ID" value="MZL33505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705340.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000018_gene59"/>
    <dbReference type="EnsemblBacteria" id="CUO05340">
        <property type="protein sequence ID" value="CUO05340"/>
        <property type="gene ID" value="ERS852478_01716"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP65326">
        <property type="protein sequence ID" value="CUP65326"/>
        <property type="gene ID" value="ERS852523_02332"/>
    </dbReference>
    <dbReference type="GeneID" id="66492358"/>
    <dbReference type="eggNOG" id="COG1436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO05340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP65326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL33505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS89828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX63793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="102" mass="11510" checksum="699624D598026126" modified="2016-09-07" version="1">MQMFLISDNIDTYTGMRLAGVEGVVVHTHDELKDALQKAISNKEIGIILLTEKFGREFPEIIDDVKLHHKTPLIIEIPDRHGTGRKPDFITSYVNEAIGLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C8I9</accession>
    <name>A0A174C8I9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200274.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08016">
        <property type="protein sequence ID" value="CUO08016"/>
        <property type="gene ID" value="ERS852478_01801"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09024">
        <property type="entry name" value="Aldose_epim_lacX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037481">
        <property type="entry name" value="LacX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO08016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="294" mass="33775" checksum="93718BA8FAA8C7DC" modified="2016-09-07" version="1">MQIKLQSDNYHVLLNTLGAELNSYSNPSGNEYVWNSDPAYWLRSSPLLFPTVGNVRNGETVIKDHIYQMPKHGFCKESEFEVTEQTENSVTFLLKANEETLKHYPYDFELYLSYHLNGSTLSMDYRVINKDSDIMYYHIGAHPGFMCPVNNGENIENCILRFEKEENFISYEYDIKNLEFNFNHKVSQKAEGNTLPLTISMFDQDAVFFEHTNSHYVSFVNAITGKGVSVYYPDFESLAIWTPAGGKAPFLCLEPWNGSGIFHQDDDIFAHKHGILTLESGKEKAYHLEISLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CCC2</accession>
    <name>A0A174CCC2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200364.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10437">
        <property type="protein sequence ID" value="CUO10437"/>
        <property type="gene ID" value="ERS852478_01854"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO10437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="147" mass="17025" checksum="5834AF1CA6C20336" modified="2016-09-07" version="1">MTEYMGRYADFVQYSTSRGYIVFGNDIISHGRSITTKSSCLYLSNWNDTVKDMITAREYVSNKYPELPISLLVFSLGSFIVRTNADLSPYKKEILIGTGAQSAFLMRIMRTWIWKKYTERMSCASDEIYDLMFGTYSKKFKGRPANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CCF4</accession>
    <name>A0A174CCF4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO09959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200339.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09959">
        <property type="protein sequence ID" value="CUO09959"/>
        <property type="gene ID" value="ERS852478_01839"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO09959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="227" mass="26028" checksum="347B86B46591CA44" modified="2016-09-07" version="1">MKRLTIKGFKTARFLLKAAASGIESLLEETYPVLREGAKRIGLSPKDFTHIEISNKAFNEATSIKGIYPFCKITYIADHIDGFQYRIRIGWKKTDEDIVPDILYIQKVMTDGEFDLDYILSFTENPEKGCCWISEGKRPRRIVNNIPDGWIGVEEDLPEPGKLNENTLDYQNYMCLVQVVEGKSADARPLAFTENRQWVNGNVDMTDYVLAWQDIPKCRNEKVVLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CCY1</accession>
    <name>A0A174CCY1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">H(2)O-forming NADH oxidase</fullName>
            <ecNumber evidence="3">1.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fprA1</name>
        <name evidence="3" type="ORF">ERS852478_01862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.</text>
    </comment>
    <dbReference type="EC" id="1.6.3.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200377.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10667">
        <property type="protein sequence ID" value="CUO10667"/>
        <property type="gene ID" value="ERS852478_01862"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="252"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO10667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="393" mass="43970" checksum="4730317460800FA5" modified="2016-09-07" version="1">MTIQTVTDAIRYVGVDDNTLALFENQYPVQPMGVSYNSYVILDEKIAVMDSVDVRAAEEWLSNVARVLEGRSPYYLVVTHMEPDHSGSLMRLAQKYPEMKIVGNAKTFTLIKQFFGTGALSEDRMLEVGERDTLSLGLHRLSFLLAPMVHWPEVMAAYEEEEKILFSADAFGRFGSLERTARAPWAPQARRYYYNIVGKYGAQVQALLKKISALEIKTICPLHGPMLTEDLGEYLRLYDLWSQWKPEKSEDILIAHASIHGNTAYASEALKSKLEGKGAQVTMCDLTATDLSYAVTSAFYCGKLVLACSTYDGGLFPPMKAFLDHLQTKGFRNRRIGLMENGSWAPAAARLMRAELEKMKELRLCETDVSLRGALNQTSEAQMDALVAELCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CDW2</accession>
    <name>A0A174CDW2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted HKD family nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01846</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200349.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10160">
        <property type="protein sequence ID" value="CUO10160"/>
        <property type="gene ID" value="ERS852478_01846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="187"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO10160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="673" mass="77824" checksum="8DEED27BBC379594" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CK58</accession>
    <name>A0A174CK58_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CDP-glycerol:glycerophosphate glycerophosphotransferase</fullName>
            <ecNumber evidence="10">2.7.8.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="6">CDP-glycerol:poly(Glycerophosphate) glycerophosphotransferase</fullName>
            <ecNumber evidence="6">2.7.8.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tagF_2</name>
        <name evidence="10" type="synonym">tagB_2</name>
        <name evidence="10" type="ORF">BWLFYP14_02220</name>
        <name evidence="6" type="ORF">ERS852478_01910</name>
        <name evidence="7" type="ORF">ERS852523_01964</name>
        <name evidence="9" type="ORF">GT712_17495</name>
        <name evidence="8" type="ORF">GT728_10785</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="10"/>
    <dbReference type="EC" id="2.7.8.12" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000018">
        <property type="protein sequence ID" value="CUP54365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000023">
        <property type="protein sequence ID" value="MZL33671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000051">
        <property type="protein sequence ID" value="MZS90802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381306.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000004_gene1950"/>
    <dbReference type="EnsemblBacteria" id="CUO12095">
        <property type="protein sequence ID" value="CUO12095"/>
        <property type="gene ID" value="ERS852478_01910"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP54365">
        <property type="protein sequence ID" value="CUP54365"/>
        <property type="gene ID" value="ERS852523_01964"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO12095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP54365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL33671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS90802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX65855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="429" mass="51151" checksum="17807C6495E9B570" modified="2016-09-07" version="1">MKKRIKKKIKKLKKSINKINKVRVQKGRKAMLQETWATVTYGLYDNRKIRRLKKFPPALVENRMLFETNDDFTDNGRALFDYLIEKGYNKKYEIVWLVHEPSKYKEYQFENVKFVQNFKKGSTIRRAEAYKYALTSKYIFYTQAFNWIGMSRRNQLFIDLWHGCGYKANKNGRKVFFDYCLVPGDIFIKTKMEFFGCTSKKLLSFGYPRYDMMLKGSERADEYKKKLLKETDSEKLILWMPTYRHASSERLNEETLNNEFNIPIIDDADKLLELNKFCKENHILIVIKKHYLQVPYDFGENVLTNIVYLENRDLADNGLQLYEFINCSDALVSDYSSVAIDYLLLDRPLGFTLDDYEAYTESRGWVFDDPLEYMPGEHMYNMQDFENFILDIKNGKDNYKEQRASVRAKTHNVCDNYCQRVLDYFNITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CNW1</accession>
    <name>A0A174CNW1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in cyanobacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02184</name>
        <name evidence="2" type="ORF">ERS852478_01949</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703581.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13448">
        <property type="protein sequence ID" value="CUO13448"/>
        <property type="gene ID" value="ERS852478_01949"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO13448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="181" mass="20984" checksum="8C5C4E914106B635" modified="2016-09-07" version="1">MPLLKEEAYTIDDIYALPDGERAELIDGRMYMMAPPSRKHQRISTRLVSIIDRYIEEHKGKCEVYAAPFAVYLDERSNTYVEPDISVICDPDKLDDRGCKGAPDWIIEIVSPASKKMDYLLKLLKYRFAGVKEYWIVDPEKNRVIVYNFTGDESVNDYTLQDFVKVGIYEDFVIDFGSMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CP29</accession>
    <name>A0A174CP29_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalt import ATP-binding protein CbiO</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Energy-coupling factor transporter ATP-binding protein EcfA1</fullName>
            <ecNumber evidence="8 9">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cbiO</name>
        <name evidence="9" type="synonym">ecfA1_2</name>
        <name evidence="9" type="ORF">BWLFYP14_02183</name>
        <name evidence="8" type="ORF">ERS852478_01950</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="8 9"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703583.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13475">
        <property type="protein sequence ID" value="CUO13475"/>
        <property type="gene ID" value="ERS852478_01950"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO13475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX65818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="215" mass="24337" checksum="2461959CA5950C0F" modified="2016-09-07" version="1">MIKFENVVFGYGEEKNALNYVSFHISEGEQVGLIGANGAGKSTLMKAMLGLIPAKGKITVDEIEVNQENSSRIWQCLRYVFQDSDNQMFMPTVYEDMIFGPLNYGKSRKEADQLAREALEELDLIHLKDRQNYKMSGGEKRMAAIATILAMNPKVMLMDEPSTALDPKNRRRLIRILQKLPTTKIIATHDLESKMTAADADIYICFVRIKKQVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CYJ5</accession>
    <name>A0A174CYJ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA interferase</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ndoA_1</name>
        <name evidence="7" type="synonym">ndoA_2</name>
        <name evidence="7" type="ORF">BWLFYP14_02367</name>
        <name evidence="4" type="ORF">ERS852478_02077</name>
        <name evidence="6" type="ORF">GT712_14190</name>
        <name evidence="5" type="ORF">GT728_13890</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">BIOML-A1</strain>
            <strain evidence="6 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PemK/MazF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO18223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000035">
        <property type="protein sequence ID" value="MZL34265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000030">
        <property type="protein sequence ID" value="MZS90188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053836.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18223">
        <property type="protein sequence ID" value="CUO18223"/>
        <property type="gene ID" value="ERS852478_02077"/>
    </dbReference>
    <dbReference type="GeneID" id="66493751"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO18223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL34265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS90188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX65997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="121" mass="13595" checksum="A883E8F7A6FE7FAB" modified="2016-09-07" version="1">MTIRRGDILWADLGMFPTTSVQGGVRPVIVVSNNKANTYSSVITVVPLTSRIYKKRYLPTHVFISKYDMTGIRKGSLALAEQVMSISTKCIIEKCGRVNKWSLDRVLKAVRIQMGMEEKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DCE6</accession>
    <name>A0A174DCE6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">serS</name>
        <name evidence="11" type="ORF">ERS852478_02171</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200602.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21715">
        <property type="protein sequence ID" value="CUO21715"/>
        <property type="gene ID" value="ERS852478_02171"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="143"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO21715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="430" mass="49067" checksum="83BE62C728CA2A73" modified="2016-09-07" version="1">MLDIKFVRENPEVVKQNIRNKFQDNKLELVDKVLELDKENREIKQEVEALRAERNKISKQIGALMAQGKKEDAEEVKKQVAASGTRIEELSTREKEVEEELLKDMMVIPNIIDPSVPIGKDDSENVEIEKFGEPVVPNFEVPYHTEIMENFDGIDLDSARRVAGNGFYYLMGDIARLHSAVISYARDFMINRGFTYCVPPFMIRSNVVTGVMSFAEMDAMMYKIEGEDLYLIGTSEHSMIGKFIDQIIPEEELPKTLTSYSPCFRKEKGAHGLEERGVYRIHQFEKQEMIVVCRPEESPMWFDKLWQNTVDLFRSLDIPVRTLECCSGDLADLKVKSLDVEAWSPRQKKYFEVGSCSNLGDAQARRLKIRVNGKDGKKYLAHTLNNTVVAPPRMLIAFLENNLNADGSVSIPKALQPYMGGMTKIEKKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DEK9</accession>
    <name>A0A174DEK9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding S4 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Ribosome-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybcJ</name>
        <name evidence="4" type="ORF">BWLFYP14_02851</name>
        <name evidence="1" type="ORF">ERS852478_02190</name>
        <name evidence="3" type="ORF">GT712_11370</name>
        <name evidence="2" type="ORF">GT728_11210</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">BIOML-A1</strain>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000025">
        <property type="protein sequence ID" value="MZL33750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708001.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22356">
        <property type="protein sequence ID" value="CUO22356"/>
        <property type="gene ID" value="ERS852478_02190"/>
    </dbReference>
    <dbReference type="GeneID" id="66493382"/>
    <dbReference type="eggNOG" id="COG2501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO22356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL33750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS89655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="69" mass="7898" checksum="F7F108352301B390" modified="2016-09-07" version="1">MEEIKIRDEFIKLGQLLKLADMVQDGVEAKYVITDGLVKVNGEVDDRRGRKVYEGDIVSYDGKEIKVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DFT4</accession>
    <name>A0A174DFT4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PSP1 C-terminal conserved region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tpl</name>
        <name evidence="2" type="ORF">ERS852478_02208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707977.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22880">
        <property type="protein sequence ID" value="CUO22880"/>
        <property type="gene ID" value="ERS852478_02208"/>
    </dbReference>
    <dbReference type="GeneID" id="66493399"/>
    <dbReference type="eggNOG" id="COG1774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="61"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO22880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="299" mass="34296" checksum="AD3D4DABCDD2BA83" modified="2016-09-07" version="1">MTKVVGVRFRNVGKIYYFSPKDYEIKTGDHVIVETARGIEYGKVVLAPREVDEEDVVHPLKEVLRVATKEDDEREAQNRVREREAFKICQKKIREHGLEMKLIDAEYTFDNNKVLFYFTADGRIDFRQLVKDLAAIFKTRIELRQIGVRDETKILGGIGICGRCLCCHTYLSEFAPVSIKMAKEQNLSLNQTKISGVCGRLMCCLKNEQETYEELNKKLPGLGDTVTTPDGLTGTVHSVNVLRQRVKVIVEINDEKEIQEFPVDDLKFRPRKKKVKVSEKELKELGNLEDKKGDSKLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DG49</accession>
    <name>A0A174DG49_9FIRM</name>
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        <submittedName>
            <fullName evidence="4">Probable endopeptidase p60</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">iap_4</name>
        <name evidence="4" type="ORF">ERS852478_02249</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
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            <taxon>Clostridia</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_055200647.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24612">
        <property type="protein sequence ID" value="CUO24612"/>
        <property type="gene ID" value="ERS852478_02249"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019990" evidence="2">
        <location>
            <begin position="30"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="211"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO24612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="335" mass="36553" checksum="9D7EC61F683A33BD" modified="2016-09-07" version="1">MKLKHIALIGSLFPILFSLVLFFGVLISADSDDENSNFSSGITGMNLSAEVLKHQPMVEKYAREYGISEYVNVLLAIIQVESGGTAEDVMQSSESLGLPPNSLDTESSIKQGCKYFASLLSSCKNQGIDDLNVAIQSYNYGGGYVGYVAGKGKKHTYNLAESFAREKSGGKKVTYTNPIAVAKNGGWRYGYGNMFYVELVNQYLTVPQVSGELAQKVMNEALKYQGWKYVYGGSNPNTSFDCSGLTQWCYGKAGISLPRTAQAQYDATQHLPLSQAKAGDLVFFHSTYNAGTYVTHVAIYVGNNQIYHAGDPIGYADLSSSYWQQHLIGAGRVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DGR3</accession>
    <name>A0A174DGR3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF3789)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200657.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24772">
        <property type="protein sequence ID" value="CUO24772"/>
        <property type="gene ID" value="ERS852478_02254"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024522">
        <property type="entry name" value="DUF3789"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12664">
        <property type="entry name" value="DUF3789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO24772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="44" mass="5048" checksum="3C4B42CA4FB8DDE5" modified="2016-09-07" version="1">MWVLLKDFLQVSMGMGIGVVLMCILNVGKEADYKMKQLRESEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DKJ4</accession>
    <name>A0A174DKJ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200642.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24536">
        <property type="protein sequence ID" value="CUO24536"/>
        <property type="gene ID" value="ERS852478_02246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO24536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="144" mass="16998" checksum="A6333FBC76DEB00D" modified="2016-09-07" version="1">MKSLKNPMTNAIYIASITAIYAMIFIVSSEFVSKYAYWLSDSWWSLFIQNKNMKFIGLGMIGIAIIIDIFSVLRRKKYDEYQIIALEKIMLFNGLFITIIFPLSLFILIFAPIYFVETIFAFILFQWLCMVITEVLYLFKNYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DPI5</accession>
    <name>A0A174DPI5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01582</name>
        <name evidence="2" type="ORF">ERS852478_02337</name>
        <name evidence="3" type="ORF">ERS852523_01604</name>
        <name evidence="4" type="ORF">GT712_12680</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO27354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP43506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381070.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000136_gene977"/>
    <dbReference type="EnsemblBacteria" id="CUO27354">
        <property type="protein sequence ID" value="CUO27354"/>
        <property type="gene ID" value="ERS852478_02337"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP43506">
        <property type="protein sequence ID" value="CUP43506"/>
        <property type="gene ID" value="ERS852523_01604"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO27354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP43506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="136" mass="15949" checksum="5B2DB6AF061394BB" modified="2016-09-07" version="1">MKDKLNRFMQGRYGVDNFARFTLGVALFVIVVGSFMRQNAAGGVLDTVGFILIIYTYFRILSRNISARYAENQKYLGYTQKIRSRFTREKNMMEQRKTHHIYTCPGCGQKIRIPRGKGQKVEIECPKCHEKFIKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DS82</accession>
    <name>A0A174DS82_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aroA1</name>
        <name evidence="7" type="synonym">aroA</name>
        <name evidence="9" type="ORF">ERS852478_02352</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200702.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28442">
        <property type="protein sequence ID" value="CUO28442"/>
        <property type="gene ID" value="ERS852478_02352"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="19"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO28442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="424" mass="45066" checksum="D90A0610CA1ABA4D" modified="2016-09-07" version="1">MEIKKQTNLRGELTVPGDKSISHRAVMFGSLAQGTTKITHFLEGADCLSTISCFRKMGIDIERNASEILVHGKGLHGLSAPFETLDVGNSGTTTRLISGILAGQSFTSELNGDASIQSRPMKRIMTPLLSMGADIVSLRGNGCAPLRITGKPLHAAHYQSPVASAQVKSCVLLAGMYADGITSVTEPVLSRNHTEIMLNYFGANVTSQGTTASIEPEPVLNGREIKVPGDISSAAYFIAAGLLTPESEILLKNVGINPTRDGMLRVCKAMGADITLLNASTEGEPTADLLIHTSSLHGTTVEGEIIPTLIDEIPMIAVMAAFAEGTTVIRDAQELKVKESDRIAVVTEGLKRMGADIQPTDDGMIIHGGKPLHGAEINSYLDHRIAMSFAVAGTICDGTLTIKDGDCVKISYPEFYEDLYSLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DT57</accession>
    <name>A0A174DT57_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">rpsP</name>
        <name evidence="4" type="ORF">ERS852478_02361</name>
        <name evidence="5" type="ORF">ERS852523_00964</name>
        <name evidence="7" type="ORF">GT712_13740</name>
        <name evidence="6" type="ORF">GT728_07920</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">2789STDY5834863</strain>
            <strain evidence="5 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">BIOML-A1</strain>
            <strain evidence="7 10">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP23391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000014">
        <property type="protein sequence ID" value="MZL33133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000029">
        <property type="protein sequence ID" value="MZS90105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704685.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1080"/>
    <dbReference type="EnsemblBacteria" id="CUO28741">
        <property type="protein sequence ID" value="CUO28741"/>
        <property type="gene ID" value="ERS852478_02361"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23391">
        <property type="protein sequence ID" value="CUP23391"/>
        <property type="gene ID" value="ERS852523_00964"/>
    </dbReference>
    <dbReference type="GeneID" id="66494249"/>
    <dbReference type="eggNOG" id="COG0228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO28741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP23391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL33133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS90105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="81" mass="8987" checksum="CE319F1170F2D62B" modified="2016-09-07" version="1">MAVKIRLRRMGQKKAPFYRIVVADSRCKRDGRCIEEIGTYDPNLEPSAVTVDEEAAKKWLAAGAQPTDVVAKILKDAGIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DV94</accession>
    <name>A0A174DV94_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gmk_2</name>
        <name evidence="9" type="synonym">gmk</name>
        <name evidence="11" type="ORF">ERS852478_02343</name>
        <name evidence="12" type="ORF">GT728_07830</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000014">
        <property type="protein sequence ID" value="MZL33115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704533.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28148">
        <property type="protein sequence ID" value="CUO28148"/>
        <property type="gene ID" value="ERS852478_02343"/>
    </dbReference>
    <dbReference type="GeneID" id="66494231"/>
    <dbReference type="eggNOG" id="COG0194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO28148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL33115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="207" mass="23502" checksum="8FC07B53702066AD" modified="2016-09-07" version="1">MNKGILVVVSGFSGAGKGTVMKRLMEKYDGYALSVSATTRKPRPGEEDGREYFFRTRDEFEKLIEEDALLEYAQYVENYYGTPRSYVEEQLQAGRNVILEIEIQGAMKIKEKIPEALLVFVTPPTVEELERRLTGRGTETAQVIADRLARAGEEAEGMGQYDYILVNDTVEECVDHLHQIIVSEHSRVSRNAEFIADIQKQTKAFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DVL0</accession>
    <name>A0A174DVL0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized ACR, COG1399</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200735.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29257">
        <property type="protein sequence ID" value="CUO29257"/>
        <property type="gene ID" value="ERS852478_02377"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO29257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="175" mass="19515" checksum="B9B0E83C277F25E3" modified="2016-09-07" version="1">MQIHLSDISSSEGMRIQKTAEFGMDTITFQSGSFPVLAKEPIELTITNTGDRNLEIKGTGKITVGIPCDRCLEEVSTEIPLEIERKLDMKLTDEDRVNDLDESSYLTGMDLDVDQLVYLEVLMSWPLKVLCREDCKGICSQCGKNLNDGPCGCVEEPKDPRMAAISDIFSKFKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DVW0</accession>
    <name>A0A174DVW0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative regulatory protein BWLFYP14_02931</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_02931</name>
        <name evidence="2" type="ORF">ERS852478_02344</name>
        <name evidence="3" type="ORF">ERS852523_01075</name>
        <name evidence="5" type="ORF">GT712_13825</name>
        <name evidence="4" type="ORF">GT728_07835</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP26516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000014">
        <property type="protein sequence ID" value="MZL33116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000029">
        <property type="protein sequence ID" value="MZS90122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000072">
        <property type="protein sequence ID" value="VUX66655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704535.1">
        <property type="nucleotide sequence ID" value="NZ_JADPFJ010000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1063"/>
    <dbReference type="EnsemblBacteria" id="CUO28185">
        <property type="protein sequence ID" value="CUO28185"/>
        <property type="gene ID" value="ERS852478_02344"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26516">
        <property type="protein sequence ID" value="CUP26516"/>
        <property type="gene ID" value="ERS852523_01075"/>
    </dbReference>
    <dbReference type="GeneID" id="66494232"/>
    <dbReference type="eggNOG" id="COG2052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01503">
        <property type="entry name" value="RemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007169">
        <property type="entry name" value="RemA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38449">
        <property type="entry name" value="PTHR38449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04025">
        <property type="entry name" value="DUF370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO28185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP26516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="90" mass="9871" checksum="77DABB727EC0F2E6" modified="2016-09-07" version="1">MARLINIGFGNVVNSQKIVAVVSPDAAPVKRMVQSIKGTRSLIDATQGRKTKAVIVTSDDYLVLSALQPETIARRFAEIYENEDKGETHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DXV8</accession>
    <name>A0A174DXV8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <shortName evidence="6">PBG</shortName>
            <ecNumber evidence="6">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="6">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">hemC</name>
        <name evidence="10" type="ORF">BWLFYP14_00128</name>
        <name evidence="9" type="ORF">ERS852478_02409</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="6">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060042.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30284">
        <property type="protein sequence ID" value="CUO30284"/>
        <property type="gene ID" value="ERS852478_02409"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobil_deam" evidence="7">
        <location>
            <begin position="5"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobil_deamC" evidence="8">
        <location>
            <begin position="226"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="6">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO30284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX66575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="301" mass="33082" checksum="87E1631FA8F1C768" modified="2016-09-07" version="1">MTEVIIGSRESKLAVLQSEMVKSYIEQKNREKNAGSEITVNILTMKTTGDIILDRTLDKVGGKGLFVKELDRALLDGKSNLSVHSLKDMPMEVPEELPLLAFSKREDPRDVLVLPEGVAELDPDKPLGCSSLRRTLQLKKLYPEMEVKSIRGNLQTRLRKLDEGEYSGLILAAAGLKRLGLENRISRYFTPDEMIPSAGQGILAVQGRKGEDYGYLDGYCDRDAWLAGTAERAYVKYLDGGCSSPVAAFAEVGGDEIFIRGLYYSEATGKWLTGQIRGAAEDGEKLGTALAKQLKSDCEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E0H8</accession>
    <name>A0A174E0H8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xanthine dehydrogenase accessory protein XdhC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO31263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200753.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPB010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31263">
        <property type="protein sequence ID" value="CUO31263"/>
        <property type="gene ID" value="ERS852478_02442"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="82"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="244"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO31263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="331" mass="36657" checksum="1F0C5BB8BE4F767B" modified="2016-09-07" version="1">MYRKIYQILEETGKVKTAMVLNGNHKGEKCLIKENHCLSSDENTADFWKKYEADLAECQETKVVHMGDVDFFVEIYVKNPQLIIFGGGHVSQPVAKIGKMLGFHVTVMDDREDFVTSERFPDADRLIKGSYDKLSDKIPAYENAYYVIVTRGHLGDSACARQILRRPYTYLGMIGSKNKIKLTREKLLGEGFSEEQLNSIHAPIGLPIGGHMPAEIAVSIAAEIVQEKNRYDVSYIDGAVEDAVRKKENGIMITIISKSGSSPRGTGSKMFIDKDGNSYGSIGGGNVEFQALKYAPEAQHGEIRKYNLSNQGGANLGMICGGEVEVLYELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EAV1</accession>
    <name>A0A174EAV1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO34773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34773">
        <property type="protein sequence ID" value="CUO34773"/>
        <property type="gene ID" value="ERS852478_02537"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO34773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="633" mass="70249" checksum="0780610CD9811423" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ECF7</accession>
    <name>A0A174ECF7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052404.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35373">
        <property type="protein sequence ID" value="CUO35373"/>
        <property type="gene ID" value="ERS852478_02558"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8E0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045714">
        <property type="entry name" value="DUF6070"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19546">
        <property type="entry name" value="DUF6070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO35373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="385" mass="45858" checksum="57CA8611270BB413" modified="2016-09-07" version="1">MKKIWKIFWGVIFLAVCSGCGIKKEQKKTIEDTKEKIYRECEMLAEDYQSIYENAAKENALYELSTIQKSMDYFGKYGYAVIDSYNQLDMVQSIKVDDFLKKAEKEKNGKTTIFQVIAGDHFIRYDLKTKQGKIDVEVSSFKWKEDTWQETYYHEFRANSWKYTENGYFFMEEYHPAGYDGPSGYRAFRVVPLNKKCRELNRKYILPFGYTLNKLFTSNWSEKNYDGINFYDVFDRLLSMEEKTDEFKEGKTYEIPKESFEAIFQKYFNISAEILQTGTVFHTETQTYRYRTRGIVYDFAPTPYIPYPEVVSYIENQDGTITLEVNAVWPQKELDQAFCHSVTIRLLDKDRFQYVSNYVSRSEIEVTWYTERLSDEKWEECYGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EIA1</accession>
    <name>A0A174EIA1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="16">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="16">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="16">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="18" type="primary">nnr</name>
        <name evidence="14" type="synonym">nnrD</name>
        <name evidence="15" type="synonym">nnrE</name>
        <name evidence="18" type="ORF">ERS852478_02615</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15 16">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14 16">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 14 16">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="15 16">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="16"/>
    <dbReference type="EC" id="5.1.99.6" evidence="16"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO37017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200803.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37017">
        <property type="protein sequence ID" value="CUO37017"/>
        <property type="gene ID" value="ERS852478_02615"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12 14 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="7 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="17">
        <location>
            <begin position="10"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="60"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="126"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="406"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CUO37017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="499" mass="53918" checksum="AC545D546FD78CC0" modified="2016-09-07" version="1">MREIVTAVEMKELDHNTIQKAGISSPVLMERAALKTVEEIVQRLKNKEKEKILVVCGTGNNGGDGLAIARLLQLRGVRTWYYIAGKEEKMTAETAGQLKTAEYYQVPRVHNLDLDEYTTIVDAIFGVGLSRPVEGKYAELISTMNRASAYKVAVDIPSGIDSDTGFEKGIAFRADLTVTFAFRKRGLCFYPGRMYGGEIVVTDIGIYSIPGKKICMHHLEREDLKMLPERVPYGNKGTFGKVLLIAGSEGMCGAAYLSAAAALKSSAGMVRIQTVEANRIPLQTLLPEAIITCDFDEKKNQAMLDWCDVLVIGPGLGTGAQSRERAQWFLAKAAECKKTVILDADGLNLLSVHDNWKRFIGEHVILTPHIGEMSRLCGKEIGKIQDCLAQTAADYAKESGAVCVLKDACTVVADAFGDMYLNISGNAGMATAGSGDVLSGVLAGIQCMYLVAEKKFSPVMLAALGVYVHGLAGDLAAETVGQRGMTAGDIICFLPEILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EJH3</accession>
    <name>A0A174EJH3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">rnhB</name>
        <name evidence="17" type="ORF">BWLFYP14_02465</name>
        <name evidence="14" type="ORF">ERS852478_02597</name>
        <name evidence="15" type="ORF">ERS852523_00194</name>
        <name evidence="16" type="ORF">GT728_02730</name>
    </gene>
    <organism evidence="14 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">2789STDY5834863</strain>
            <strain evidence="15 19">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="16 21" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 21">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="17 20" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000002">
        <property type="protein sequence ID" value="CUO99927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000050">
        <property type="protein sequence ID" value="VUX66093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703905.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000003_gene1611"/>
    <dbReference type="EnsemblBacteria" id="CUO36539">
        <property type="protein sequence ID" value="CUO36539"/>
        <property type="gene ID" value="ERS852478_02597"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99927">
        <property type="protein sequence ID" value="CUO99927"/>
        <property type="gene ID" value="ERS852523_00194"/>
    </dbReference>
    <dbReference type="GeneID" id="66494116"/>
    <dbReference type="eggNOG" id="COG0164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="72"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO36539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO99927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZL32134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VUX66093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="251" mass="28028" checksum="86914C922360F16B" modified="2016-09-07" version="1">MKTIAEIKAEFAAADMSSYPALYEIYKEDTRSGVQKLIAQCRKKEAALEAEKQRIENMKVYEHKYEHLGYLCGIDEVGRGPLAGPVVACAVILPQDSRILYLNDSKKLSASKREELYDVIMREAVSVGIGMRSPERIDEINILQATYEAMREAVSKLEVVPQLLLNDAVTIPQITIPQVPIIKGDAKSVSIAAASIVAKVTRDRMMEEYDKVFPEYGFASNKGYGSADHIAALKKYGETPIHRKTFITHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F0T6</accession>
    <name>A0A174F0T6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerol-3-phosphate transporter periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200928.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43167">
        <property type="protein sequence ID" value="CUO43167"/>
        <property type="gene ID" value="ERS852478_02794"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021236" evidence="1">
        <location>
            <begin position="32"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO43167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="431" mass="48352" checksum="E20B123BC2828236" modified="2016-09-07" version="1">MRKMKKVLSLAMTAAMTASLLTGMGAVTASAKKSDDGKRTKITALLKGTESTEQYKTFNYLLKNFCDEKGLDYEIELVNDMQDYFTKLQMYINSDTLPDIFGCPNGTLSKACKDIDALVNVGDELERNGYDEKLNGAIRDFLTDADDGNMYLFPQGLYCEYFMYRKDIFEKAGIKDAPTTWEEFEEDCQKIADQGEIPVIVGGSDAWQLMRYLSFSPWRVTGPEFIEGYQAGTDSFSDNESAKYAVNLLSDLGTKGYFEPGFASVDFTSACNLFFGGSGAIFYTGSGQISLAEEMYDNGELGFFPVPDTEGMDNMSTNVPVHAGFAEGFNKATYDDTMQEFFDYMCENFTDACYNQAQVFSPFNEELPEGLPQLYYDTQPMFEDAETAWTSWDDKLDSDVMTKIVDEQQQLAQGIIKPDEFIKTCDSLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F6U9</accession>
    <name>A0A174F6U9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45391">
        <property type="protein sequence ID" value="CUO45391"/>
        <property type="gene ID" value="ERS852478_02866"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014925">
        <property type="entry name" value="CGGC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08821">
        <property type="entry name" value="CGGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01078">
        <property type="entry name" value="CGGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CGGC" evidence="1">
        <location>
            <begin position="38"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO45391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="152" mass="17199" checksum="EFCBA5F38BE5BBA7" modified="2016-09-07" version="1">MTAAGRCIFYFYNMSIDRPESGKFLTLACYIWRKKMNKIGILTCIHSNNVCARVGCLAAFQNRTDFFQDYPEDTCLAAMMTCNGCKGANPIEPIEDKGILEKIDRLVSEKISTIHVGVCRLPDGKHECPRMTQICNMIEERGIKVVRGTHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F743</accession>
    <name>A0A174F743_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380568.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45367">
        <property type="protein sequence ID" value="CUO45367"/>
        <property type="gene ID" value="ERS852478_02865"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO45367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="310" mass="36448" checksum="455713BF5572B66B" modified="2016-09-07" version="1">MAKRKNKKIIVKRNRLKGNTATANRKYKDTVFRMLFSDRKNLLSLYNAINETSYTDVAQLEIVTLENAIYMGMKNDLAFIINTNLFLYEHQSTYNPNMPLRDLFYISSEYQKMVDWKSLYTSTRLRIPTPNFIVFYNGTEKKEDRWVDYLSESYENMSGEPNLELKVITLNINVGHNKKLMEECRTLREYAQYVDKVRRYSNEMELNTAVERAVSESIQEGILKEFLQKNRAEVVAMSIFEYNEEEEKRKLRKAEYEAGMAEGVMKTKKETAISLAEMGLSVQQIAQGVKVEEKTVHKWLNEKKNMKTTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FEV3</accession>
    <name>A0A174FEV3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">ICEBs1 excisionase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xis_3</name>
        <name evidence="4" type="ORF">BWLFYP14_03407</name>
        <name evidence="2" type="ORF">ERS852478_02905</name>
        <name evidence="3" type="ORF">GT712_17965</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000055">
        <property type="protein sequence ID" value="MZS90882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705154.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46655">
        <property type="protein sequence ID" value="CUO46655"/>
        <property type="gene ID" value="ERS852478_02905"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TrmB" evidence="1">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO46655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX67130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="63" mass="7352" checksum="74091A2CD86D5FA8" modified="2016-09-07" version="1">MRTNYMMTVDDVMEELGVKRSKAYSVLKQLNDELAKEGYVAVRGKIPRPYWETKFYGCSQRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FFU4</accession>
    <name>A0A174FFU4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cardiolipin synthase</fullName>
            <ecNumber evidence="14">2.7.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cls_4</name>
        <name evidence="15" type="synonym">cls_2</name>
        <name evidence="14" type="ORF">ERS852478_02983</name>
        <name evidence="15" type="ORF">ERS852523_01467</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">2789STDY5834863</strain>
            <strain evidence="15 17">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="14"/>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO49142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP39203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053772.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000037_gene3242"/>
    <dbReference type="EnsemblBacteria" id="CUO49142">
        <property type="protein sequence ID" value="CUO49142"/>
        <property type="gene ID" value="ERS852478_02983"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP39203">
        <property type="protein sequence ID" value="CUP39203"/>
        <property type="gene ID" value="ERS852523_01467"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022924">
        <property type="entry name" value="Cardiolipin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04265">
        <property type="entry name" value="bac_cardiolipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO49142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUP39203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="519" mass="59137" checksum="BB7FB73A254D87B5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FM66</accession>
    <name>A0A174FM66_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal large subunit pseudouridine synthase D</fullName>
            <ecNumber evidence="2">5.4.99.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rluD_4</name>
        <name evidence="2" type="ORF">ERS852478_03028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.23" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201080.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPC010000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50607">
        <property type="protein sequence ID" value="CUO50607"/>
        <property type="gene ID" value="ERS852478_03028"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO50607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="233" mass="25933" checksum="936FA8AF8CD70451" modified="2016-09-07" version="1">MWIKDIRDYILYEDKDILVCHKPAGLAVQNARVGSMDMESLLKNYIAQKVPGKMPYLGIIHRLDQPVEGVLVFALNPKAAANLSRQMTAGKIKKTYLAVTEGTVKVKSAKLVDWLKKDGRTNSSAVVEGGTSGAKKAILSYEVLETWKNKEDAQDCGERNLIRIDLDTGRHHQIRVQMAHAGMPLVGDRKYNPGQNSQEPLALCSAKLGFQHPVTKKQLEFQVQPAGMAFKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FXM7</accession>
    <name>A0A174FXM7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53668">
        <property type="protein sequence ID" value="CUO53668"/>
        <property type="gene ID" value="ERS852478_03115"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO53668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="184" mass="21547" checksum="B4D9FEE071D9557A" modified="2016-09-07" version="1">MNDEMVALLKSGRINNRLLCELATHKDFIKFLADIEIYVDGIATMQIQNLNSLVDTVRHEIIERYRPGEDDPHLKVLQAAHISDDEYFSHMVLDDLNLIIRDIREFHKKDSESAPQTTVADELKENLEAVENFKGSRDEKLVILYCKQLGINYKNLSEEEFRWFIRILKKSKKMGTPISQRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G3J3</accession>
    <name>A0A174G3J3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO54915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201210.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54915">
        <property type="protein sequence ID" value="CUO54915"/>
        <property type="gene ID" value="ERS852478_03154"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="81"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO54915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="137" mass="16219" checksum="2C786489CF61668F" modified="2016-09-07" version="1">MKKINLRELYPDVYITDFFVDVTEEVMETIRAAERAEAAYERKMYRYKAQYSLDCENGIENAVLLKPQTPEMLLEEKQFQEQVYATVMKLPEKQAKRIYARYYLGMAVNEIAEVEGVDPSRVRDSIRRGLKQLVKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G428</accession>
    <name>A0A174G428_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ftsE_2</name>
        <name evidence="6" type="synonym">ftsE</name>
        <name evidence="9" type="synonym">ftsE_1</name>
        <name evidence="9" type="ORF">BWLFYP14_00320</name>
        <name evidence="8" type="ORF">ERS852478_03217</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707358.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57302">
        <property type="protein sequence ID" value="CUO57302"/>
        <property type="gene ID" value="ERS852478_03217"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO57302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX67475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="227" mass="25485" checksum="A753CF8B8C678562" modified="2016-09-07" version="1">MIDLIDVSKSYGPGLPAVNHANLHIDKGEFVFVVGNSGSGKTTLIKLLMKELDSTSGQIIVSGERLEGMKHRRVAKYRRKLGVVFQDFRLLKDRNVYENVAFAQRVVNRPTRVIRKRVPEVLQEVGLAVKYKSFPDELSGGEQQRVALARALVNRPDILLADEPTGNLDPKTSEEIMKLLEQINDRGTTVVVVTHNKDIVNSMRKRVVTMHEGSIISDEKEGEYHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G526</accession>
    <name>A0A174G526_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">tgt</name>
        <name evidence="10" type="ORF">BWLFYP14_02240</name>
        <name evidence="6" type="ORF">ERS852478_03204</name>
        <name evidence="7" type="ORF">ERS852523_01943</name>
        <name evidence="9" type="ORF">GT712_14590</name>
        <name evidence="8" type="ORF">GT728_18225</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000018">
        <property type="protein sequence ID" value="CUP53799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000068">
        <property type="protein sequence ID" value="MZL35061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000032">
        <property type="protein sequence ID" value="MZS90264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703492.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000004_gene1932"/>
    <dbReference type="EnsemblBacteria" id="CUO56707">
        <property type="protein sequence ID" value="CUO56707"/>
        <property type="gene ID" value="ERS852478_03204"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP53799">
        <property type="protein sequence ID" value="CUP53799"/>
        <property type="gene ID" value="ERS852523_01943"/>
    </dbReference>
    <dbReference type="GeneID" id="66493903"/>
    <dbReference type="eggNOG" id="COG0343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="13"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="4">
        <location>
            <begin position="254"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO56707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP53799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL35061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS90264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX65874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="383" mass="43392" checksum="E36A03882FF897EE" modified="2016-09-07" version="1">MAEYKLLKTEGRAKRAEFHTVHGTIQTPVFMNVGTIGAIKGAVSTMDLQQIGTQVELSNTYHLHVRPGDKIVKQLGGLHKFMVWDKPILTDSGGFQVFSLAKLRKIKEEGVYFNSHIDGHKIFMGPEESMQIQSNLASTIAMAFDECPSSVADRDYVQKSVDRTTRWLARCKAEMARLNSLPDTINKEQLLFGINQGAVYEDIRIEHAKAISEMDLDGYAVGGLAVGETHEEMYRILDAVVPYLPQNKPTYLMGVGTPANILEGVERGIDFFDCVYPSRNGRHGHVYTNHGKMNLFNAKYELDTRPIEEGCQCPACQHYSRAYIRHLLKAKEMLGMRLCVLHNLYFYNHMMEEIRDALDAGNFAEYKKMRLEGFEEGKINSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G5J0</accession>
    <name>A0A174G5J0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Spermidine/putrescine import ATP-binding protein PotA</fullName>
            <ecNumber evidence="8">7.6.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">potA_2</name>
        <name evidence="8 11" type="synonym">potA</name>
        <name evidence="10" type="ORF">ERS852478_03194</name>
        <name evidence="11" type="ORF">GT712_14540</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.11" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000032">
        <property type="protein sequence ID" value="MZS90255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059478.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56408">
        <property type="protein sequence ID" value="CUO56408"/>
        <property type="gene ID" value="ERS852478_03194"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015594">
        <property type="term" value="F:ABC-type putrescine transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03300">
        <property type="entry name" value="ABC_PotA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017879">
        <property type="entry name" value="PotA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005893">
        <property type="entry name" value="Sp_pt_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01187">
        <property type="entry name" value="potA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="6"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO56408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS90255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="399" mass="43364" checksum="1A1657B566E174AF" modified="2016-09-07" version="1">MAEVSLELKEIKKSFTEGEAVLDNISLEISKGEFITLLGSSGCGKTTTLRIIAGLEQPDAGSVWLDGREVTGLEPNQRDVNTVFQNYALFPHMNVAENIGYGLKLKKVPKSEIRKKVSQMLELVQLEGYEKRKPSELSGGQKQRVAIARALVNNPKVLLLDEPLGALDLQLRRAMQIELKHLQKKLGITFIYITHDQEEAINMSDRIAVMRDGRIEQIGTPDEIYNHPKTSYVATFVGNANILHGVAESIQGENAIVKIGNDKVIVKLETSQQNTGAKQHLTAGENVTLAVRSENILLQEAAAIGDTGTDNGDTVDISVAGGISDIHDTNSISGLQATVTEKNFAGGQLRVTLKLSDGTQLIASRYGIDASVAEGQTVRCSFLPTDAVLVDREDIHEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G628</accession>
    <name>A0A174G628_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitric oxide reductase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57431">
        <property type="protein sequence ID" value="CUO57431"/>
        <property type="gene ID" value="ERS852478_03222"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025861">
        <property type="entry name" value="CobT_VWA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11775">
        <property type="entry name" value="CobT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobT_C" evidence="2">
        <location>
            <begin position="395"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO57431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="599" mass="69748" checksum="DDF795DBFB2335CB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GIS5</accession>
    <name>A0A174GIS5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ANTAR domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380270.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60799">
        <property type="protein sequence ID" value="CUO60799"/>
        <property type="gene ID" value="ERS852478_03327"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ANTAR" evidence="1">
        <location>
            <begin position="116"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO60799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="184" mass="20871" checksum="7531B1B28F747AC0" modified="2016-09-07" version="1">MSSSIVIALPKIEDAKKIRTILNRHGLTVASVCSSVSNALASISELDSGVLICGYKLTDAYYKDALDDLPQYFEMLLLASQRIIDEAPNSVSTVQMPMKASALIDTVNDMLYHLERRIKKEKKKPKPRSEKEQNYISNAKRLLMEKNQMTEEEAYRHIQKCSMDSGTNMVETAQMLLMLMYDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GJP5</accession>
    <name>A0A174GJP5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201303.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61607">
        <property type="protein sequence ID" value="CUO61607"/>
        <property type="gene ID" value="ERS852478_03349"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO61607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="311" mass="36102" checksum="EAC3DD5BF0A620AD" modified="2016-09-07" version="1">MKKGKAFEIIVKRIFIRIGFSEVYSDGLYVYNGTAGQMIQGLGNSHNADVLLEPLVQTPFYSQTRLLIECKDYKDKVGLNIVRGILGLREDINHFEIVDNNILQERRKQNRKVINNCPHARYTYQVAIASTSGFSTYAQEFAATHRISLIEFNKMPFWNKLMNLIGEKGDADIEEEELKKNVDKISSHMAVAITNMGQLLFLYCQSGMVDFPADEYDILWRNKNEPWTLRCGDKEYSFQLPEYIIESWINYSENEIEMKKKVIENKSTFFSNMIVYYCCDQKPVIKMISIDFEKLKEAKKKLNEIANGNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GLP8</accession>
    <name>A0A174GLP8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn_dep_PLPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63293">
        <property type="protein sequence ID" value="CUO63293"/>
        <property type="gene ID" value="ERS852478_03402"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029002">
        <property type="entry name" value="PLPC/GPLD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00882">
        <property type="entry name" value="Zn_dep_PLPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_dep_PLPC" evidence="1">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO63293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="264" mass="30692" checksum="A3E7324BC3620746" modified="2016-09-07" version="1">MPTTYAHDLFGKEVYKRLPSDMKALIRRHGDLYRIGLHGPDILFYYMVSKNPVTQFGIEMHHEKARAFFEEGMRQVRRNDDEALFAYLLGFGCHYILDSTCHPYVNKMAAEGVIPHIVLEKEFDRVLMEETGKDPDHYYPACGIMPKMEYARVIHRAIPLVKTINIYISVRMMKILTNFMVCDDHGRKRRILGKLLRLGGESIGSVIEHFMTAEAVEQAKAPMPELERLYREAVPEAVEYLGELYTLREGAYHLSKRWDRTYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GN51</accession>
    <name>A0A174GN51_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glucose 1-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.47</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fabG_3</name>
        <name evidence="5" type="synonym">fabG_2</name>
        <name evidence="5" type="ORF">BWLFYP14_02259</name>
        <name evidence="2" type="ORF">ERS852478_03425</name>
        <name evidence="4" type="ORF">GT712_16300</name>
        <name evidence="3" type="ORF">GT728_10895</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EC" id="1.1.1.47" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000024">
        <property type="protein sequence ID" value="MZL33691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000042">
        <property type="protein sequence ID" value="MZS90579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058919.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64004">
        <property type="protein sequence ID" value="CUO64004"/>
        <property type="gene ID" value="ERS852478_03425"/>
    </dbReference>
    <dbReference type="GeneID" id="66495129"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047936">
        <property type="term" value="F:glucose 1-dehydrogenase [NAD(P)] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO64004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="251" mass="26096" checksum="F761AC7713780057" modified="2016-09-07" version="1">MKFENKVAIITGSTRGIGRATAELFAKEGAKVIVVGTKEELGESCVNEIKAAGGEAIFCKTDVTSDESLDNLVKTALDAYGKIDILVNNAGVGGTTANMDQITMDEWNTVLATNLTAPFVLCKKLIPIMEKQGAGTIVNVASMAATAAGRGGLAYTSAKHGLLGLTRQMSLDHGRTGVRINAVLPGPIATDMIARVLAIPQHPVTMKIGMSPAKRPGEPIEVAQAIAFLASDEASFIHGAALAVDGGYTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H2T2</accession>
    <name>A0A174H2T2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01605</name>
        <name evidence="3" type="ORF">ERS852478_03545</name>
        <name evidence="4" type="ORF">GT712_09255</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705640.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67626">
        <property type="protein sequence ID" value="CUO67626"/>
        <property type="gene ID" value="ERS852478_03545"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO67626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="166" mass="20039" checksum="F9CE527E8DC21D42" modified="2016-09-07" version="1">MNQQLTTVTEEIEELKSRKEQLIFQAECSTDKDMTNLSKKYDQMNNNLDILDSQDISLKKQLEKDAAAFREEKFRPEPEQYTELLDTRIQIRPDFRDKLIEQLKGTFGKYYDYHRRDIAANEVDYLNAEDPDVFSHRAWELEYQRKQEMRRNQPARTKKKSYDMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H3X4</accession>
    <name>A0A174H3X4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_01609</name>
        <name evidence="1" type="ORF">ERS852478_03550</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67729">
        <property type="protein sequence ID" value="CUO67729"/>
        <property type="gene ID" value="ERS852478_03550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO67729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX64755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="50" mass="5921" checksum="148E1920AD2ED0E5" modified="2016-09-07" version="1">MRKVDELRNVIANQFACEYKTYDFGEICNAFIDDLIRLMENSIKNEQGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H702</accession>
    <name>A0A174H702_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO69991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015561462.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69991">
        <property type="protein sequence ID" value="CUO69991"/>
        <property type="gene ID" value="ERS852478_03621"/>
    </dbReference>
    <dbReference type="GeneID" id="66303222"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO69991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="123" mass="13907" checksum="BEFC2EB970CDBE5C" modified="2016-09-07" version="1">MADGMSFSFPSLLFHEGRTYGQPEVVPISLPQVATGLRSRLPGSFRRRGFQPDLLMPQEALFAREAHSMQAAMRRALLRRGRSGNAAFSKIESNVAGNLYRMCRKEESRYGDFSLHNQNSRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HA44</accession>
    <name>A0A174HA44_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO69725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69725">
        <property type="protein sequence ID" value="CUO69725"/>
        <property type="gene ID" value="ERS852478_03609"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038721">
        <property type="entry name" value="IS701-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13546">
        <property type="entry name" value="DDE_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_5" evidence="1">
        <location>
            <begin position="78"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="431" mass="50193" checksum="8FD9FC12C0C3332B" modified="2016-09-07" version="1">MIYFETFSVPTADTLFLLILSILALESAHSIRFLYQHFLSGITEKSLNVFYYVCSYAKVDYSRFMNTTVRITLKLIPDSLQTQPVFLCVDDTMVSKFGTKFENVSKLFDHAAHNGSNYLNGHCFVSVMLCVPVWNRDKVSYLSVPLGYRMWQKKESKLELAASMIRQVMPEFHSKDHVIILCDSWYTKQNLVSIVDEYPNLDLIGNARIDSVMYDLAPAQTGRRGRPAKHGKHLSVETDFTFSNEKIGDYYTGVRRVLAKIFGNREVLAYVTATEKEHGTKRLFFSTIFPEDLQIFCAWQEKAPLNQTGSDRMKYIPLLLYSLRWNIETSYYEQKTFWSFCNYMVRSCKGIEMLVNLINISYCAMKILPYQNEHFSEYRTKSVQEFRFELSQGIRSQIFFATFVKNIETHIKSNAMTKALKQLIHQQVYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HBN1</accession>
    <name>A0A174HBN1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted signal transduction protein with a C-terminal ATPase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381447.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPB010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70520">
        <property type="protein sequence ID" value="CUO70520"/>
        <property type="gene ID" value="ERS852478_03636"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="2">
        <location>
            <begin position="324"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO70520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="422" mass="48173" checksum="FF1A07108814429E" modified="2016-09-07" version="1">MSEQILSAVHGVTTMLFGIYCSAFFLGIKPIRKNILTMFLLFLGQGLLYVIDLALFGETLANMSYPLIVHFPLVLFLSVHYKYPLISSAVSVFSAYLCCQISNWTGLFALAITGLQWCYYSVRILTTTLTFVLLYRYVFRSTKTIFTKNARELSIIGFLPFVYYVFDYASTKFSTLLYSGNKAVVEFMGFAFCIAYLVFLIIYFQEYENKQEITQYSNLREMQLQSMQNEIEQVKISSQRLAILRHDMRHHLSIILTQLQNGHPDKAQEYIHEINSAYDDTIIAAYSGNEMLNSVLSIYHSRFADRGLSLICNVSTGKELPCSDLSLCTILSNALENSMHALEQLESPSKWARLTLSQKKNHILFQLENPVEKIPAFVDGVPVSTRNGHGIGVRSIIYYVEQLHGQCHFSIVDHCFVLRIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HCG2</accession>
    <name>A0A174HCG2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF819 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Putative transporter YfdV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_03643</name>
        <name evidence="9" type="ORF">GT728_01735</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL31954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993719.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70709">
        <property type="protein sequence ID" value="CUO70709"/>
        <property type="gene ID" value="ERS852478_03643"/>
    </dbReference>
    <dbReference type="GeneID" id="66494340"/>
    <dbReference type="eggNOG" id="COG0679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO70709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL31954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="314" mass="34037" checksum="AA2C2991DEB4AB87" modified="2016-09-07" version="1">MENLIFCLNATIPIFLTLMLGLFFRKIGLFDDTFVSRLNKFVFNAALPALLFLDIAKSDFYSVWNTKFVLFCFFVTLISIGISTGLSYLLKPRNIQGEFIQASYRSSAAILGIAIIQNLYGNAGMAPLMIIGSVPLYNVMAVITLSLFAPGGGKLDTAKLIRTLKGIATNPIILGILTGMVWSLLHLPMPTILNTAVDNLGKTATPLGLMAMGGALKFGKAFARPKPLIACSFLKLVGYEAVFLPLAVLLGFSHDMLVAIIIMLGSATTVSCYIMAKNMDYDGDFTSGVVMTTTLLSSFTMTIWLYICKSLGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HE08</accession>
    <name>A0A174HE08_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379852.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71145">
        <property type="protein sequence ID" value="CUO71145"/>
        <property type="gene ID" value="ERS852478_03656"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026989">
        <property type="entry name" value="TnpV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14198">
        <property type="entry name" value="TnpV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO71145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="127" mass="15024" checksum="38FBEFF76561353A" modified="2016-09-07" version="1">MEKLEKVIVENGITYVLGEDDIYYPDLQLPEGTNYNIGKFGHMRCEYLKEFRHGYYMELLLEGKLNEYLHDIDEECHEMLDRIVEKMKEKQDVTEQLKAENQMLWVGKMNNIIACAEAVVVREVVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HF46</accession>
    <name>A0A174HF46_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03677</name>
        <name evidence="2" type="ORF">GT712_06800</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000010">
        <property type="protein sequence ID" value="MZS88785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201488.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000072.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71629">
        <property type="protein sequence ID" value="CUO71629"/>
        <property type="gene ID" value="ERS852478_03677"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO71629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS88785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="209" mass="24241" checksum="F65C12E61F500E4D" modified="2016-09-07" version="1">MPNKLPKFFDKHKICIICEGNEEYEYLKRLKDLNVWNEQYEVSLVNAGGNGNIPARYQDRYQNGADELVLVFCDTEKKPHEQYEDIKRKINVFHGVDNAADEVIMFGNPCTMQIISKHWTDENLKSPAKPVNVPLIKKYTGVENYKGRADQINEVMKYVTVENYKDMSRRVKDLDSDDSVTGSSNFGKFIKLFESDDSGWIEKINEQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HLU7</accession>
    <name>A0A174HLU7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF2812)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000053">
        <property type="protein sequence ID" value="CUO75884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201539.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75884">
        <property type="protein sequence ID" value="CUO75884"/>
        <property type="gene ID" value="ERS852478_03816"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021359">
        <property type="entry name" value="DUF2812"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11193">
        <property type="entry name" value="DUF2812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO75884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="195" mass="22901" checksum="55D19775599B1681" modified="2016-09-07" version="1">MSKKYYRFFGGLLTAQEHWLNKMSEKGYRLIRAEKMLYEFEACKPDQVKYCVEFIGQKSKADASDYHEFLEGMGYKVFYKNINLNYSVGKVRLRPWAEKGGRIATNATTFNRELLIVEKDNDGKPFELHTSYEDKENYYRNLRNPWLLILLMFAIFAVAKCSVVFGVLALVSLIPVLVYQTQVMQNKREGKTKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HR47</accession>
    <name>A0A174HR47_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">graR_4</name>
        <name evidence="9" type="ORF">ERS852478_03813</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000053">
        <property type="protein sequence ID" value="CUO75797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201537.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000102.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75797">
        <property type="protein sequence ID" value="CUO75797"/>
        <property type="gene ID" value="ERS852478_03813"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO75797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="222" mass="25180" checksum="EF6789CF7E74A420" modified="2016-09-07" version="1">MKEKILIIEDDPLIRNELKTLLQSNSYKTVAPEDFSDVIDQIKAEQPHLIILDIKLPGTSGFSLCTEIRTFSEVPIIFVTSCNTDMDELNSIMLGGDAFITKPYNTAILLAKIASLLKKVYPTQQREQIVYGDAVLHLESSSLDYHGQSVELTKNELKILYYLFKNGGKICSRGDMIEYLWDNQLYVDDNALSVNINRIREKLAGIGLTDFIKTKHRQGYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HR87</accession>
    <name>A0A174HR87_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000051">
        <property type="protein sequence ID" value="CUO75365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201533.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75365">
        <property type="protein sequence ID" value="CUO75365"/>
        <property type="gene ID" value="ERS852478_03802"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008023665" evidence="1">
        <location>
            <begin position="35"/>
            <end position="1304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO75365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1304" mass="140921" checksum="162BC6652D22AF9C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KSZ4</accession>
    <name>A0A174KSZ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein required for the initiation of cell division</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00709</name>
        <name evidence="5" type="ORF">ERS852523_00635</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
            <strain evidence="5 7">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP12655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000016_gene3654"/>
    <dbReference type="EnsemblBacteria" id="CUN65304">
        <property type="protein sequence ID" value="CUN65304"/>
        <property type="gene ID" value="ERS852478_00709"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12655">
        <property type="protein sequence ID" value="CUP12655"/>
        <property type="gene ID" value="ERS852523_00635"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YRK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN65304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP12655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="192" mass="21900" checksum="E77DDE1DFC004EE8" modified="2016-09-07" version="1">MARTTRSETARRSRTSARTNRGMYVDGNTVRRLAEVPERKRQPGRQNPGRQQTNRNRRVQASPAQVPRQKHQLSKEAQKNRQKATAMNWGFVAFLAVICVAILFCSVKYLRYKSEITAKMSTVASLEEELADLKEDNDAYYSQVTSNVDLNKIKQIALGRLGMKYPSDDQTVTYSTSGNSYVRQYQDIPDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LPR9</accession>
    <name>A0A174LPR9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">D-lactate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ldhA</name>
        <name evidence="8" type="ORF">BWLFYP14_02922</name>
        <name evidence="5" type="ORF">ERS852478_02353</name>
        <name evidence="6" type="ORF">ERS852523_01066</name>
        <name evidence="7" type="ORF">GT728_07880</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
            <strain evidence="6 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.28" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP26254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000014">
        <property type="protein sequence ID" value="MZL33125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000072">
        <property type="protein sequence ID" value="VUX66646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704545.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1072"/>
    <dbReference type="EnsemblBacteria" id="CUO28482">
        <property type="protein sequence ID" value="CUO28482"/>
        <property type="gene ID" value="ERS852478_02353"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26254">
        <property type="protein sequence ID" value="CUP26254"/>
        <property type="gene ID" value="ERS852523_01066"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="4"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="111"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO28482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP26254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="329" mass="36685" checksum="17E9F8D86E943DDE" modified="2016-09-07" version="1">MKILFYGTKNYDEEFFEKLLPSYPGITIKFTEANIHEETASLAKGYEAICAFVNADLSTPVIEELNAQGVKLILMRCAGYNNVDLETAHKFGMKVLRVPGYSPEAVAEHAMALALTANRHTHKAYIKCRENNFSLSGLMGLNFYQKTAGIIGTGKIGQAMAKICKGFGMRVIAYDLFPNKSLDYLEYVSLDELLATSDLISLHCPLTEETKHIINEETIAKMKDGVILVNTSRGGLIKTEDLISGIRDHKFFAVGLDVYEEETDFVFEDMSERILQSSITQRLLSFPNVVMTSHQGFFTKEALTNIAETTLENAKAFMDGNELKNEVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MBJ7</accession>
    <name>A0A174MBJ7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xanthine phosphoribosyltransferase</fullName>
            <shortName evidence="1">XPRTase</shortName>
            <ecNumber evidence="1">2.4.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">xpt</name>
        <name evidence="3" type="ORF">ERS852478_01691</name>
        <name evidence="4" type="ORF">ERS852523_01261</name>
        <name evidence="5" type="ORF">GT712_08815</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine</text>
            <dbReference type="Rhea" id="RHEA:10800"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.22" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP32626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380651.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2949"/>
    <dbReference type="EnsemblBacteria" id="CUO03778">
        <property type="protein sequence ID" value="CUO03778"/>
        <property type="gene ID" value="ERS852478_01691"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP32626">
        <property type="protein sequence ID" value="CUP32626"/>
        <property type="gene ID" value="ERS852523_01261"/>
    </dbReference>
    <dbReference type="GeneID" id="66496155"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00602">
        <property type="reaction ID" value="UER00658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000310">
        <property type="term" value="F:xanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046110">
        <property type="term" value="P:xanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01184">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010079">
        <property type="entry name" value="Xanthine_PRibTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01744">
        <property type="entry name" value="XPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="2">
        <location>
            <begin position="52"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="1">
        <location>
            <begin position="128"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>xanthine</name>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO03778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP32626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="190" mass="21002" checksum="A86190A308FD9395" modified="2016-09-07" version="1">MKLLKDRILKDGVVKPGNILKVDSFLNHQMDITLINEIGKEFKRRFSDCPITKILTIEASGIGIACIAAQYFDVPVVFAKKAQSVNLDGEMYTTKVESFTHKKVYDVILSRKFLGPEDHVLLIDDFLANGCALLGLIDIVKKSGATLEGAGIVIEKGFQHGGQEIRDMGIRLESLAIVDSMTDDSLTFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MWZ6</accession>
    <name>A0A174MWZ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_03541</name>
        <name evidence="1" type="ORF">ERS852478_03026</name>
        <name evidence="2" type="ORF">ERS852523_01434</name>
        <name evidence="3" type="ORF">GT728_10195</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
            <strain evidence="2 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP38209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000021">
        <property type="protein sequence ID" value="MZL33559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380881.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000010_gene2809"/>
    <dbReference type="EnsemblBacteria" id="CUO50552">
        <property type="protein sequence ID" value="CUO50552"/>
        <property type="gene ID" value="ERS852478_03026"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP38209">
        <property type="protein sequence ID" value="CUP38209"/>
        <property type="gene ID" value="ERS852523_01434"/>
    </dbReference>
    <dbReference type="GeneID" id="66495464"/>
    <dbReference type="eggNOG" id="ENOG5032S4Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO50552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP38209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX67266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="90" mass="10969" checksum="ACC24BB6F0360C88" modified="2016-09-07" version="1">MFRLWGKIWKDNHLLKDTVICDDSEDTRTHKIFRGLESICYEMDLGNPIWLESTVRHFKKHGKARFYQDNFIEQIDFDYLEIQVIEEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174N087</accession>
    <name>A0A174N087_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8 11">inner membrane ABC transporter permease protein YcjP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ycjP_10</name>
        <name evidence="7" type="synonym">ycjP_2</name>
        <name evidence="11" type="synonym">ycjP_4</name>
        <name evidence="11" type="ORF">BWLFYP14_01992</name>
        <name evidence="7" type="ORF">ERS852478_00373</name>
        <name evidence="8" type="ORF">ERS852523_01562</name>
        <name evidence="10" type="ORF">GT712_06040</name>
        <name evidence="9" type="ORF">GT728_06460</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUP42023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZL32852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZS88659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000060_gene478"/>
    <dbReference type="EnsemblBacteria" id="CUN52627">
        <property type="protein sequence ID" value="CUN52627"/>
        <property type="gene ID" value="ERS852478_00373"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP42023">
        <property type="protein sequence ID" value="CUP42023"/>
        <property type="gene ID" value="ERS852523_01562"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetI-like"/>
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        <property type="entry name" value="MetI-like_sf"/>
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        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="93"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
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            <begin position="135"/>
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            <end position="260"/>
        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CUN52627.1"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CUP42023.1"/>
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            <dbReference type="EMBL" id="MZS88659.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="275" mass="30695" checksum="AB951F61CFC24686" modified="2016-09-07" version="1">MKTVRTWCIRILMILFTVIFLYPLFWNLMSAFKTNAEYLTDPYALPTALNLDNFVAAWQKANIAAYFGNSIFVTVFSTVLLLLLVIPISYVLARYRFAGSKLISAIYMACIFLQATYIMIPLFLELQAVNGLNNLPVLCLVYAVMQFPFCIFTLQGFMSAVPRDYEESARIDGATNIQLLSRVMVPLAKPGIATITMLSAMGFWNEYPLALVLLTEDAKKTLPIGMANLFEVQKYATDWGALFAGLVIIMIPTIIIYLIGQRYLLQGIGAGGLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174RX05</accession>
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            <fullName evidence="5">Extracellular solute-binding protein</fullName>
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        <submittedName>
            <fullName evidence="4">Maltose-binding periplasmic proteins/domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03002</name>
        <name evidence="4" type="ORF">ERS852523_03206</name>
        <name evidence="5" type="ORF">GT728_10075</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO49922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_WWVQ01000021.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CUO49922">
        <property type="protein sequence ID" value="CUO49922"/>
        <property type="gene ID" value="ERS852478_03002"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP90194">
        <property type="protein sequence ID" value="CUP90194"/>
        <property type="gene ID" value="ERS852523_03206"/>
    </dbReference>
    <dbReference type="GeneID" id="66495440"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF3502"/>
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        <property type="entry name" value="SBP"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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        <location>
            <begin position="24"/>
            <end position="492"/>
        </location>
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    <feature type="domain" description="DUF3502" evidence="2">
        <location>
            <begin position="354"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12010"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CUO49922.1"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CUP90194.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZL33535.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="492" mass="54671" checksum="277ABE4B0C385FC6" modified="2016-09-07" version="1">MNKKVIAAGMAMVLASMGLTACGDSGSKEAKDSSDETYTVTMAYIGDKEEDTDRIEKKINEIMKKDINMELDIEPISWGAYAETMKLILSGGEKMDIVPILVEQVNSMVNAKQVIDMSEYIDKYGNNIKELLGDTAKAANIGNYVYGVTTGREWFCQSSVIMRKDILDECGIDVSSITDYKDLTDVYATVKEKYPDMVMMASNNSATPDTKYEMNDTLTDGFGVLMDHGQDTTVVDYYETDEYKEFVETMYDWQQKGYLSKDAATTTESAENQVKAGAAFSYLAPNKPGYDTRAALLCGTEMEIAPISEPWAGTAQISYLTYGISSSSADKDKTMQCLDYLYGNADILNLLNWGEEGVDYEVVDAENNIINYPDGKDDSNTYHLAEGWQLFDQFKMHIWEGDSPDIWDETKALNESAIKSKAFGFTYDSTSVANELAALSNVKAKYAAALGSGTVDPEETLPKFIEELKKAGIEKVISTKQEQLDKWLEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174T6U2</accession>
    <name>A0A174T6U2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03683</name>
        <name evidence="3" type="ORF">ERS852523_03748</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO71931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUQ04786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008393101.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71931">
        <property type="protein sequence ID" value="CUO71931"/>
        <property type="gene ID" value="ERS852478_03683"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ04786">
        <property type="protein sequence ID" value="CUQ04786"/>
        <property type="gene ID" value="ERS852523_03748"/>
    </dbReference>
    <dbReference type="GeneID" id="15230414"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ04786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="141" mass="16569" checksum="C30DB7665018292A" modified="2016-09-07" version="1">MKKKLPFIIEIIIGIIFICFGYFVIDTDYYSTLFYAIGLGLAFASGVQLLKICYYEMPKNKEKLENINRENHINNVDERKVFLRMKAGSLVYQIMTFVYLFVAFVFALLHIEAWIIGVIFGLFLLQTFLGIVLYKHFEKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174T9V5</accession>
    <name>A0A174T9V5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC-type transporter ATP-binding protein EcsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ecsA_2</name>
        <name evidence="5" type="synonym">ecsA_5</name>
        <name evidence="5" type="ORF">ERS852478_03692</name>
        <name evidence="6" type="ORF">ERS852523_03756</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
            <strain evidence="6 8">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO72070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000063">
        <property type="protein sequence ID" value="CUQ04877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_044929915.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72070">
        <property type="protein sequence ID" value="CUO72070"/>
        <property type="gene ID" value="ERS852478_03692"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ04877">
        <property type="protein sequence ID" value="CUQ04877"/>
        <property type="gene ID" value="ERS852523_03756"/>
    </dbReference>
    <dbReference type="GeneID" id="66302975"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO72070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUQ04877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="299" mass="33494" checksum="699AAB1DA7B03BD8" modified="2016-09-07" version="1">MDMLRITNLKKHFGDKEVLTGLNLSVPEHSVFGFVGENGAGKTTTMKIILGLLKSDRGEVFVSGERVKYGQTATNRYIGYLPDVPEFYSFMTAREYLRLCGESLEMGKNDIEKRSDELLTLVGLSKENHRIRGFSRGMKQRLGIAQALLGRPKILICDEPTSALDPIGRKEILDILLSSKKQTTVLFSTHILSDVERICTDVAFLNNGKIAMQGAVADLKNVCSSHEFIVETIKADDAEYLSSVFTDAQLTAKDTLLFLGEQFKMFEVLEFITEHKILISKIERVEPSLESLFMEVVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174TAM0</accession>
    <name>A0A174TAM0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase IS116/IS110/IS902 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02942</name>
        <name evidence="4" type="ORF">ERS852523_03765</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
            <strain evidence="4 6">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000064">
        <property type="protein sequence ID" value="CUQ05137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025581332.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000181.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47579">
        <property type="protein sequence ID" value="CUO47579"/>
        <property type="gene ID" value="ERS852478_02942"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ05137">
        <property type="protein sequence ID" value="CUQ05137"/>
        <property type="gene ID" value="ERS852523_03765"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="2">
        <location>
            <begin position="6"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO47579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUQ05137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="403" mass="45947" checksum="3B0003FBE0E314B7" modified="2016-09-07" version="1">MNMNAVGIDVSKGKSMVAILRSYGEIISKPFEVKHTVSGIRSLIEQIQSIDGESRIVMEHTGRYYEPLVRELSKADLFVSAINPKLIKDFGDNSLRKVKSDKADAVKIARYTLDSWTELRQYSLMDEIRNQLKTMNRQFDFYMKHKTAMKNNLISILDQTYPGANTYFDSPAREDGSQKWVDFSATYWHVDCVRKLSLNAFIDHYQKWCKRRKYNFSRSKAVEIYEASKELVSILPKDDLTKLIIKQAVEQLNTASQTVEQLRTMMNEAASKLPEYPVVMAMKGVGKSLGPQLMAEIGDVSRFTHKGAITAFAGVDPGVNESGSYEQKSVPASKRGSSTLRKTLFQVMDVLIKTKPQDDPVYLFMDKKRAQGKPYYVYMTAGANKFLRIYYGRVKEYLSSLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WRA5</accession>
    <name>A0A173WRA5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">L(+)-tartrate dehydratase subunit alpha</fullName>
            <ecNumber evidence="8">4.2.1.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ttdA_1</name>
        <name evidence="8" type="ORF">ERS852478_00045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.32" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025576997.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN42011">
        <property type="protein sequence ID" value="CUN42011"/>
        <property type="gene ID" value="ERS852478_00045"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008730">
        <property type="term" value="F:L(+)-tartrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN42011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="280" mass="30355" checksum="ABDFDCF86DC1BC78" modified="2016-09-07" version="1">MREVEVSRLTDVIEKLCIEANEHLPEDVKCAIKTCRACEDGEIAKGVLDNIIENFDIADNENVPICQDTGMACVFLEIGQDVHFVGGNLNDAINEGVRRGYDKGYLRKSVVKDPVRRGNTGDNTPAMIYTEIVPGDQVKITVGPKGFGSENMSQIRMFKPSAGLQGIKDFILEVVETAGPNPCPPMVVGVGIGGTFDKCALLAKKALMRPLDTQNPDPFYADLEKEMLEKVNKLGIGPQGFGGKTTAIGLNIETMPTHIAGMPCAVNINCHVTRHKSEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WWU9</accession>
    <name>A0A173WWU9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ComEC family competence protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">MBL fold metallo-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00089</name>
        <name evidence="5" type="ORF">GT712_01030</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43396">
        <property type="protein sequence ID" value="CUN43396"/>
        <property type="gene ID" value="ERS852478_00089"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
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        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF56281"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
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        <location>
            <begin position="32"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="3">
        <location>
            <begin position="46"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN43396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS87708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="375" mass="40292" checksum="C1369D47629220C0" modified="2016-09-07" version="1">MKKQNRLLSLILSLFLLLFTLVPQSALTVKAEGNSEMAVHFIDVGQGNAILVQSGGQNLLYDGGDQSHADLIISYLQEQNVENIDYMIASHYDEDHIGGLVPCIDNFSVSNIFGPDYVHTSNLFNNFMNTATANAIIVQYPSVGETFDFGTGSFTVLAPNGISQNSNDNSLVIKLENGSNSFIFTGDAEETSEQDMISTGMNLDCDVLSVGHHGSASSTTWDFLEATSPSYAVISCGINNQYNHPSADTMGRLSDMGIPVFRTDKQGTIIAVSDGTNISWSQEPCNDYSSGDSSVNASAGGTGGNSWQEETTTSDPVPEQEESNNADVGTMVWIPATGEKYHSIPNCGRMNPDTARQVSRSEAEAMGYGPCSKCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WYS4</accession>
    <name>A0A173WYS4_9FIRM</name>
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        <submittedName>
            <fullName evidence="1">Cytidylate kinase</fullName>
        </submittedName>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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        <name evidence="1" type="ORF">ERS852478_00113</name>
        <name evidence="2" type="ORF">ERS852523_01877</name>
        <name evidence="3" type="ORF">GT712_00900</name>
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    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
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            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Blautia</taxon>
        </lineage>
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    <reference evidence="1 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
            <strain evidence="2 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993906.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000050.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000020_gene113"/>
    <dbReference type="EnsemblBacteria" id="CUN44066">
        <property type="protein sequence ID" value="CUN44066"/>
        <property type="gene ID" value="ERS852478_00113"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP51803">
        <property type="protein sequence ID" value="CUP51803"/>
        <property type="gene ID" value="ERS852523_01877"/>
    </dbReference>
    <dbReference type="GeneID" id="66495912"/>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN44066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP51803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS87682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="212" mass="23849" checksum="4D9F57E30AD7503A" modified="2016-09-07" version="1">MNSTSSIITIGREYGSGGRQIGQEVAKYFGIKCYDKELLEHAANESGICKELFENHDERPTNSFLYSLVMDTYSFGYSSSGFTDMPMNHKVFLAQFDAIKKLASEGPCVMVGRCADYALSEYKDCFSVFVHADTDWRINRLSQKHNKTAKEAKDMINKTDKSRSSYYNYYTNKKWGAASSYNLCVDSSKLGIDGAAKAIIQAIEIFDSIKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WZ25</accession>
    <name>A0A173WZ25_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2344 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00095</name>
        <name evidence="3" type="ORF">ERS852523_01895</name>
        <name evidence="4" type="ORF">GT728_02970</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP52265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000005">
        <property type="protein sequence ID" value="MZL32181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055151199.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000020_gene131"/>
    <dbReference type="EnsemblBacteria" id="CUN43565">
        <property type="protein sequence ID" value="CUN43565"/>
        <property type="gene ID" value="ERS852478_00095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP52265">
        <property type="protein sequence ID" value="CUP52265"/>
        <property type="gene ID" value="ERS852523_01895"/>
    </dbReference>
    <dbReference type="GeneID" id="66495930"/>
    <dbReference type="eggNOG" id="COG5011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2344" evidence="1">
        <location>
            <begin position="2"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN43565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP52265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="235" mass="26613" checksum="210EC70AE65A5C67" modified="2016-09-07" version="1">MKVRIKFSKEGPVKFVGHLDTMRYFQKAIRRANLPVAFSGGYSPHMIMSFAAPLGVGTESLGEYFDLELAETVPTSEITRRLDAVMVEGVHVLSTRQVEDGKAGKAMSLVAAADYYVEFRPGKEPEISWKDKISDFLAQPEITVMKKTKRSEKEIDIRPFIYKMELQGDKIFMMLASASANYTKPELVTDTFFSWLGIELPEFAYSIKRLEVYADKGTEEEHKFVTLEALGEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WZC8</accession>
    <name>A0A173WZC8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">radC</name>
        <name evidence="13" type="ORF">BWLFYP14_02635</name>
        <name evidence="9" type="ORF">ERS852478_00137</name>
        <name evidence="10" type="ORF">ERS852523_01853</name>
        <name evidence="12" type="ORF">GT712_00775</name>
        <name evidence="11" type="ORF">GT728_15910</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the UPF0758 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP51090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000047">
        <property type="protein sequence ID" value="MZL34638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703183.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000020_gene88"/>
    <dbReference type="EnsemblBacteria" id="CUN44714">
        <property type="protein sequence ID" value="CUN44714"/>
        <property type="gene ID" value="ERS852478_00137"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP51090">
        <property type="protein sequence ID" value="CUP51090"/>
        <property type="gene ID" value="ERS852523_01853"/>
    </dbReference>
    <dbReference type="GeneID" id="66495887"/>
    <dbReference type="eggNOG" id="COG2003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="112"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN44714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP51090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL34638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS87658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX66263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="239" mass="26645" checksum="A4579F8AE07CEC87" modified="2016-09-07" version="1">MNNANNIMKQLPREQRPYEKCFMQGEGSLNDTELLAVILRSGTSGKNSLALAQEILKFMESSSYPGLMGLMHVSVQDLMKIHGIGQVKAVQLKCIGELSKRIAKAAARPQIVMNNPSSIAAYYMEELRHEEQELVICMMSDVKGHFLGDKILTRGTATGSLVTPREIFMEALRRHAVSLILIHNHPSGDPTPSPDDLQITARIYQAGELLGIHLLDHIVIGDQRYCSFREEGLWNTCTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X4N2</accession>
    <name>A0A173X4N2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bactoprenol glucosyl transferase homolog from prophage CPS-53</fullName>
            <ecNumber evidence="3">2.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yfdH</name>
        <name evidence="3" type="ORF">ERS852478_00207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199509.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46564">
        <property type="protein sequence ID" value="CUN46564"/>
        <property type="gene ID" value="ERS852478_00207"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN46564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="311" mass="34922" checksum="771ECCE0DE1BB4DC" modified="2016-09-07" version="1">MSKLSVVLPAYNEELMVGKTCRVLAEVLTEAKIPYELVVVNDGSIDRTWEEIQKAGERDANVTGVLFSRNFGKEAAIFAGLAQACGDVVAVMDCDLQHPPQTLIEMYRLWQEGYEVIEGVKADRGKEGFLHKECAGFFYDIMSKATKVNMKDASDFKMMDRKAVDSILSMPERNMFFRATSSWVGYKTTSVEFEVQEREAGVSKWSPWALVKYAFTNIVAFTTFPLQFVTITGAICFACSLVLMVYSLVQYFTGSAVEGYTTLLMVLLLVGSAMMISLGIIGYYISKIYEEVKRRPRYIISKVIKNGNIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X5H6</accession>
    <name>A0A173X5H6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EF2563 family selenium-dependent molybdenum hydroxylase system protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Selenium-dependent molybdenum hydroxylase system protein, YqeB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00193</name>
        <name evidence="3" type="ORF">GT712_00495</name>
        <name evidence="2" type="ORF">GT728_06030</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 5 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A1</strain>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381428.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46127">
        <property type="protein sequence ID" value="CUN46127"/>
        <property type="gene ID" value="ERS852478_00193"/>
    </dbReference>
    <dbReference type="GeneID" id="66495831"/>
    <dbReference type="eggNOG" id="COG3608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017695">
        <property type="entry name" value="Se-dep_Mo_hydrolase_YqeB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03309">
        <property type="entry name" value="matur_yqeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN46127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL32776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS87606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="292" mass="31463" checksum="BA9B4E95B477BF11" modified="2016-09-07" version="1">MTNRYTNVPKSDNKPENVVIIRGGGDLASGTIHRLYRCGYRLLVLECEKPTAIRRMVSFCEAVYDGQSSVEGVLCRKVDSVEECEAVWKAGEIPLMADTEGTVLKKYRPAALIDAILAKKNLGTTREMADLTVGLGPGFVAGEDVDYVVETMRGHNLARIITKGAAMPNTGVPGIIGGFGKERVLHAPAAGEIHCISKIADIVEKDQVLAWIGDTPVRASLTGVLRGMIRDGFTVPKGMKIADIDPRKEQKKNCFTISDKARCIAGSVLEILLSEGVMPYEAPGRFSGTAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X8J3</accession>
    <name>A0A173X8J3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="17">EIICBA-Glc</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="18">PTS transporter subunit EIIC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ptsG</name>
        <name evidence="17" type="ORF">ERS852478_00222</name>
        <name evidence="18" type="ORF">GT728_05880</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
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            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
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            <strain evidence="18 20">BIOML-A1</strain>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
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</entry>
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        <source>
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    <name>A0A173XE67_9FIRM</name>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199550.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49973">
        <property type="protein sequence ID" value="CUN49973"/>
        <property type="gene ID" value="ERS852478_00288"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN49973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="394" mass="42321" checksum="3D78B48468BB2A51" modified="2016-09-07" version="1">MKTNYNRTVQACFIGYVVQAIVNNFVPLLFLTFQGSYGISLQKITLLVTFNFGIQLLVDLASIGFVDRIGYRASMILAHAMAAAGLILLTVLPECLGDPFVGLLIAVMIYAIGGGLLEVLVSPVVEACPTDNKEKAMSLLHSFYCWGHVGVVLLSTLFFRIFGIANWKYMALVWALIPIANGILFTRVPIAPLLDEGEKGLTMGELFKKKIFWVLMLMMLCAGASEQAVSQWASTLAEKSFGINKTIGDLAGPMAFAILMGSSRAFYGKFGDKINLERFMQYSAVLCMVSYLMIAFIPVPALGILGCAVCGLSVGIMWPGTFSMAAASVKRGGTALFALLALAGDVGCSSGPTYVGMISGALNDNLKLGIFAALIFPVLMILGIKMIGSLRKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XF83</accession>
    <name>A0A173XF83_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50492">
        <property type="protein sequence ID" value="CUN50492"/>
        <property type="gene ID" value="ERS852478_00305"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN50492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="229" mass="25872" checksum="1966CEDC5A3839E4" modified="2016-09-07" version="1">MKITDHKMLTEFSPAKVQFFRIDPEDISATLSDILRTLMDLSWLSKFDQDFEQKAFASRAKKTIDDIKEKFDQCVDDSISKDAGEYVVSELARETMVSELDYLDIPLDELVGKKRSGNPGFDFHSQNKITDTVIFGEAKYVATTTAYSSALPQIVDFIRDEKDVEDLPELKPFCTTSALQRAADGRKGFSAAFSAKTTNTDRIIANIKKRPDFQSLLQYEELILVAVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XGB2</accession>
    <name>A0A173XGB2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Pyruvate kinase</fullName>
            <ecNumber evidence="4 13">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">pyk</name>
        <name evidence="16" type="ORF">ERS852478_00285</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 13"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199548.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49897">
        <property type="protein sequence ID" value="CUN49897"/>
        <property type="gene ID" value="ERS852478_00285"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="14">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="15">
        <location>
            <begin position="356"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUN49897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="472" mass="51997" checksum="82B9CB84C0CAA2B8" modified="2016-09-07" version="1">MRKTKIICTMGPSTDKGDVMERLVREGMDVARFNFSHGPHDEQRGRIQKLRELRKKYDRPVAALLDTKGPEIRLGCFKDGKVFLEEGQIFTFTNKDIEGTNECVSITYKELYKDVQPGGHILVDDGLVDLEVQDIAGKDIVCKVINAGVIGDRKGVNVPGANLKMPFISKKDHDDLLFGIQEGFDFVAASFTRTANDIREVRKILKENGGEEIQIIAKIENQQGVDNIDEIIEAADGIMIARGDMGVEIPPEYVPVIQQKIIQKVYTAGKPVITATQMLDSMISHPRPTRAEATDVANAIFQGTSATMLSGETAAGKYPVQALQMMSRIAEHMEQNIDYNTIFKKTDRNENPDITNAIAHATCLTAIDLKASAILSVTKSGSTAHMMSKHRPGCLIGACTSSERVLRQLNLSWGVYPMLIREEYSSEILCLRAIEAAQKHKLVKVGDTIVFAGGVPLGIPGRTNLIRVCTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XGY7</accession>
    <name>A0A173XGY7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-N-acetylglucosamine kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_00317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + UDP-N-acetyl-alpha-D-glucosamine = ADP + H(+) + UDP-N-acetyl-alpha-D-glucosamine 3'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:32671"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:64353"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.176"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zeta toxin family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.176" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50883">
        <property type="protein sequence ID" value="CUN50883"/>
        <property type="gene ID" value="ERS852478_00317"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010488">
        <property type="entry name" value="Zeta_toxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06414">
        <property type="entry name" value="Zeta_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zeta_toxin" evidence="7">
        <location>
            <begin position="52"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN50883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="320" mass="36750" checksum="53C4BE6B654372F1" modified="2016-09-07" version="1">MNNKLLELSMNNLADEDGDILHIPHGDMPGDKINIEKSHIEKAKVIFPELIKKVKECATTNSKVVITVCGGSGVGKSEIASLLAHYFENMGVGCYTLSGDNYPHRIPVYNDAERLRIFRESAIRGMITDGEYSFERFNIIHQYQLENKDSEPKNIVKYPWYESYIRNGAMGLQGYLGTEKEINFFEIQNIVKEFKSGAEKIWLKRMGREDTELWYEEVDFSEKDILIIEWTHGNSKNYTGVDIPVLLNSTPKETLAHRRSRNRDGAVDSPFTTLVLALEQKLLRRDAHKAQIILSKNGEILTYEEYTKLMDEEESCDENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XJV9</accession>
    <name>A0A173XJV9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acpA</name>
        <name evidence="3" type="ORF">ERS852478_00356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381331.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52131">
        <property type="protein sequence ID" value="CUN52131"/>
        <property type="gene ID" value="ERS852478_00356"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50330GX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN52131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="76" mass="8847" checksum="028F3F9DEC53EF83" modified="2016-09-07" version="1">MNKEMEFKNIVAQYSKVASEEMNNEMRFREDLGFSSLDFMSFLGELEDTFDLELDESEVLKITTLGEALNLLEELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XNN0</accession>
    <name>A0A173XNN0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hyd_65N_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580038.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52487">
        <property type="protein sequence ID" value="CUN52487"/>
        <property type="gene ID" value="ERS852478_00368"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hyd_65N_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN52487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="751" mass="85917" checksum="4EB7DAF032335753" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y2W9</accession>
    <name>A0A173Y2W9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199680.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57457">
        <property type="protein sequence ID" value="CUN57457"/>
        <property type="gene ID" value="ERS852478_00500"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018698">
        <property type="entry name" value="VWA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09967">
        <property type="entry name" value="DUF2201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2201" evidence="1">
        <location>
            <begin position="307"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN57457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="456" mass="54098" checksum="72385ADB20F31B87" modified="2016-09-07" version="1">MMEPEDKTQEIAERAERLQEIGSSILRAARDELYLGMRFLDVALSSFSYQMDGQIHGFGTDGRVMYFQPQMLGGLYRENRILVNRGYLHMVFHCIFRHFAWRGTEGKKRADDGITIQERMRDLSCDIAVEHMIDGMNYRSIRFSRSLLRRETYRLLEKEGKTLNAQRVYKILSEWNLSEKDLTNLEQEFRTDDHRYWESKKPDQKPNPMLSRKWGEINDGIETDLETFSQEAGERDGDFLAQIKTENRSRYDYREFLRKFAVFHEELAVDDDSFDYNFYTYGLRLYGNMPLIEPLESKEVKKIEEFVIVIDTSMSCSGELVRKFLEETYGVLSESENFFTKINVHIIQCDEKVHTDKKITSQKEMKDYMEHLELYGDGGTDFRPAFEWVDKLLEQHEFHNLKGLIYFTDGFGIYPKKMPPYKTAFVFMQDNYRDVDVPVWAMKLILDEDDFEKPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y8J2</accession>
    <name>A0A173Y8J2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Quinolinate synthase</fullName>
            <ecNumber evidence="3">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nadA</name>
        <name evidence="10" type="ORF">ERS852478_00596</name>
        <name evidence="11" type="ORF">GT728_05305</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000009">
        <property type="protein sequence ID" value="MZL32636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053021.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60491">
        <property type="protein sequence ID" value="CUN60491"/>
        <property type="gene ID" value="ERS852478_00596"/>
    </dbReference>
    <dbReference type="GeneID" id="66492493"/>
    <dbReference type="eggNOG" id="COG0379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN60491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL32636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="305" mass="34029" checksum="8203C0FDF2BB6CE5" modified="2016-09-07" version="1">MTIAEIQQEILRMKKEQDICILAHAYQGQEILEVADYTGDSYGLSVQASKRDCSGVIMCGVRFMAETCKILSPKKRVWLANPVAGCPMAEQLDLEGLRELKAQYPDYAVVAYINTTSELKTECDVCVTSSSAVEICKKLEQDKILFIPDPNLGHYVAEKLPEKTFAFYKGGCPRHIVVSAKDVEKARAAHPDALFLVHPECRQEVAEQADYVGSTTGIMEFAKKSEHKEFIIGTENSIVEHLQFECPDKKFYPVAVQLTCMNMKVTTLMDIYNCLKGQGGEEIFLPENIMEGAGRCIHRMVELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YLB6</accession>
    <name>A0A173YLB6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Xylose import ATP-binding protein XylG</fullName>
            <ecNumber evidence="5">3.6.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xylG_1</name>
        <name evidence="5" type="ORF">ERS852478_00680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.17" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199758.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64383">
        <property type="protein sequence ID" value="CUN64383"/>
        <property type="gene ID" value="ERS852478_00680"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="265"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN64383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="512" mass="56565" checksum="345CCAEFDAEEC0D0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YXZ3</accession>
    <name>A0A173YXZ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01727</name>
        <name evidence="4" type="ORF">ERS852478_00794</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199802.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68380">
        <property type="protein sequence ID" value="CUN68380"/>
        <property type="gene ID" value="ERS852478_00794"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="169"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="438"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN68380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="517" mass="60261" checksum="92196FAEE9324E3C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YYA6</accession>
    <name>A0A173YYA6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prolyl-tRNA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052718.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPC010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69181">
        <property type="protein sequence ID" value="CUN69181"/>
        <property type="gene ID" value="ERS852478_00817"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="25"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN69181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="157" mass="17300" checksum="A48FC88A2674C5A1" modified="2016-09-07" version="1">MSLEKAEKYLEEKGFLDHVIELEASTATVTEAAEALHVEPGMIAKTMSFLQNDKAVLILTEGTARVDNRKYKDTFHIKAKMIPFDEVENIIGHAPGGVCPFGINEGIEVYLDESLKQFTTVYPAAGNDHSAVKLTISELEQVAEANGWVDVCKETEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z5G3</accession>
    <name>A0A173Z5G3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01228</name>
        <name evidence="3" type="ORF">ERS852478_00843</name>
        <name evidence="4" type="ORF">GT712_07915</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS88996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706907.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000107.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71003">
        <property type="protein sequence ID" value="CUN71003"/>
        <property type="gene ID" value="ERS852478_00843"/>
    </dbReference>
    <dbReference type="GeneID" id="66492971"/>
    <dbReference type="eggNOG" id="ENOG502ZBIU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043765">
        <property type="entry name" value="DUF5711"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18975">
        <property type="entry name" value="DUF5711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN71003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="415" mass="46583" checksum="877D1C0A608A028A" modified="2016-09-07" version="1">MANTFKKIIKKHKKKKLQAERNRKAKARERAEEEYADDYERRLSRHKRSVVKKTVITVVAIAAAVTAVGFYIEKRSYHTYKVVQTSEQEDIVSTNYVEMDGNILRYSPDGVSLVSDKMSTLWSETYQMQNPVADVNGTRAVIADKDGTTLEIYDKSGKTGSVTTSYSIVKAKVSKSGLVAAILDGGDDTWIDFYGTDGSLIAENQTKIDDPGYPLDIAVSEDGVIMMVTYQFVDGSDTTSYVAFYNFGDVGQNEDDRIVSGYKYEGVVVPQIQYLDNNRSVALKDNGFTIYHGSQIPKEVKTVKVDKEIVSTFYDNDMIGLVFKNDSKDKQYTMEVYTTDGKLKFKENFNIPYTTIKLSGGNILMYNSSQMCVMNSRGVQKYLGSVDGTIKDFFKIGMNRYLLVLDSGVEIIKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z6C9</accession>
    <name>A0A173Z6C9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Methyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01258</name>
        <name evidence="2" type="ORF">ERS852478_00876</name>
        <name evidence="4" type="ORF">GT712_08070</name>
        <name evidence="3" type="ORF">GT728_01115</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS89025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706963.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71871">
        <property type="protein sequence ID" value="CUN71871"/>
        <property type="gene ID" value="ERS852478_00876"/>
    </dbReference>
    <dbReference type="GeneID" id="66493002"/>
    <dbReference type="eggNOG" id="COG2263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="153"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN71871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL31831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="387" mass="44494" checksum="7C5024BC12A7979A" modified="2016-09-07" version="1">MKNLREYLEEQINENLIQAVLSAGRNKDGISKIKIRPIRLKGQICYQASATEGQKVLHKNYGRTELIEYVEKELAENFRQFQAQGAVTDGVVLVSKKGKMTIKQKHHEQKEKVQIQAHNRVKQYILKEGVPVPFLIDLGVMNEQGKIIHARYDKFRQINRFLEFIEDILPRLSRDREITILDFGCGKSYLTFAMYYYLRELKGYDVNIIGLDLKTDVIEKCNSLALRYGYEKLHFYHGDIADYEGVSCVDMVVTLHACDTATDYALAKAVEWGAEVILSVPCCQHEVNKQIKNEMLEPVLRYGILKERMSALITDAVRADLLESKGYDTQILEFIDMEHTPKNLLIRAVRTGKRSDQGKVEKMLAALNIHPTLDRLLNEKEQEGSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z6S9</accession>
    <name>A0A173Z6S9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Purine nucleotide synthesis repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purR_2</name>
        <name evidence="6" type="ORF">ERS852478_00849</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
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            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059433.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000089.1"/>
    </dbReference>
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        <property type="gene ID" value="ERS852478_00849"/>
    </dbReference>
    <dbReference type="GeneID" id="66492977"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN71196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="365" mass="41466" checksum="8CBDCAD43FB5431A" modified="2016-09-07" version="1">MSKKKATSSDVAKRAGVSQATVSMVLNKKYNVSFSRETVEKVEQAARELGYHLPGRKNRKESRKEKLIVVFCPTLTSPYYVLLLQGIEAVANKQGYGVFICNTQRDPRLEEKYLRMMGTIEPLGIIYCCNPNPDFQQQVEELAQTIPLVIISNKEKTTTIDAINQDNTVVGRMMARHLLDLGHRDVAFITPPLTRRQWQRTKRVNGFVKEFEKEGLKDHVIIKAADEAIDMQIPRMDSEYSMGYELTMELLDEGREFTAIAGQNDMMAIGALDALHEARIHVPKDVSVIGCDNIFYSGIRKISLTTIDHFVALKGRDACDIILRKIDEQDRFLTDSAPVSLYNIEYTPKLIARRTTGYIRTKKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZC21</accession>
    <name>A0A173ZC21_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059449.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73363">
        <property type="protein sequence ID" value="CUN73363"/>
        <property type="gene ID" value="ERS852478_00927"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033G8D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN73363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="164" mass="18508" checksum="C73285881F5DF124" modified="2016-09-07" version="1">MHINKKDLIEFDNGNMNTQEVIEFLSHLDHCDFCLDQMMEQEDSSTDTAPSYLMEQILDKADSGEVQLARAANKASRKIRLLHYSLQTAAGVMVALLLLFSIPNLDFTSLHQDTFSQTDRILPEHENGRLYQFTRELGQNIGDGTGSFIKYISDFSGKLMNGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZFX8</accession>
    <name>A0A173ZFX8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized HTH-type transcriptional regulator ybbH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybbH_1</name>
        <name evidence="3" type="ORF">ERS852478_00980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199867.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75017">
        <property type="protein sequence ID" value="CUN75017"/>
        <property type="gene ID" value="ERS852478_00980"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="127"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN75017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="285" mass="30540" checksum="FC20CFCAA895FA7B" modified="2016-09-07" version="1">MADNILDSITEQYHSLTKSGKKLADYVFSHTAETQYLSITSLAENCDVSEATITRFCRGLGLSGYNAFKLALAQADRMTDLGDSGNSAEPVSSEDSITTIAAKVHAANIISLNESYELFDEKTMTQAVSILSKARRIYCFGQGGSMVMAMEAWARFSTAAPNFIHISDSHMQASAVSLADSKDAILFFSYSGSTKDMCDTLSIASQRGVPVILVTHFPKSAGAEFATVVLQCGCNESPLQSGSVAAKVGQLFLIDCMFYGFCCHKPEARSAARSATAHAIANKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZLV7</accession>
    <name>A0A173ZLV7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CotH protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76803">
        <property type="protein sequence ID" value="CUN76803"/>
        <property type="gene ID" value="ERS852478_01035"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014867">
        <property type="entry name" value="Spore_coat_CotH_CotH2/3/7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40050">
        <property type="entry name" value="PTHR40050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08757">
        <property type="entry name" value="CotH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017005" evidence="1">
        <location>
            <begin position="29"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN76803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="597" mass="69175" checksum="8C6B05FC3EB06160" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZWG4</accession>
    <name>A0A173ZWG4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">L-cystine transport system permease protein tcyB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tcyB_1</name>
        <name evidence="8" type="ORF">ERS852478_01106</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199923.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80367">
        <property type="protein sequence ID" value="CUN80367"/>
        <property type="gene ID" value="ERS852478_01106"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="10"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN80367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="216" mass="24041" checksum="E5BAB73E64414874" modified="2016-09-07" version="1">MSLSVMLQQLASGMVVSVEIFVVTLLFSLPLGLLICFGRMSKNPAIRGIVSAYISVMRGTPLMLQLMVVYFGPYFIFGIRISMGYSLIAVFIAFSINYAAYFAEIYRGGIESISAGQYEAAKILGYSKAQTFFRIILPQVIKRILPSVTNEVITLVKDTSLAFVVAVSEMFTIAKQIASAQTTMMPFVVAAVFYFVFNLLVAIVMDKIEKKMNYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZY44</accession>
    <name>A0A173ZY44_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199931.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81144">
        <property type="protein sequence ID" value="CUN81144"/>
        <property type="gene ID" value="ERS852478_01128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008003">
        <property type="entry name" value="DUF739"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05339">
        <property type="entry name" value="DUF739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN81144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="77" mass="8741" checksum="C2BC1279D4AD3584" modified="2016-09-07" version="1">MAFDYNKLRGRIVEIFNTQSNFASAMGWSERILSLKMNGMCSWKQIDICKAIQLLKLTIEDIPIVCTQVGHYSVLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AR28</accession>
    <name>A0A174AR28_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-hexulose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hxlB</name>
        <name evidence="3" type="ORF">ERS852478_01377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIS family. PHI subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.27" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060589.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90974">
        <property type="protein sequence ID" value="CUN90974"/>
        <property type="gene ID" value="ERS852478_01377"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043800">
        <property type="term" value="F:hexulose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05005">
        <property type="entry name" value="SIS_PHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017552">
        <property type="entry name" value="PHI/rmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43443">
        <property type="entry name" value="PTHR43443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03127">
        <property type="entry name" value="RuMP_HxlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="29"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN90974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="186" mass="20175" checksum="3B052633FBC91E4D" modified="2016-09-07" version="1">MENSVILEEILEELTENAKHISSSSLEKFANEIIKARHIFVAGAGRSGFVARGFANRLMHLGLEVFFVGEPTTPAIEKKDLLIISSGSGETDSLIVMANKAKEAGASVVTVTIHPEASIGKVCESCIVIPGATPKSNLEDTSESAQPMGNAFEQMSWIVYDAVIMILMKKLGKTEEEMFKHHANLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ASM6</accession>
    <name>A0A174ASM6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable ABC transporter ATP-binding protein HI_0664</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852478_01365</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90530">
        <property type="protein sequence ID" value="CUN90530"/>
        <property type="gene ID" value="ERS852478_01365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="140"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="172"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN90530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="352" mass="38469" checksum="A11A90BCA29D78D9" modified="2016-09-07" version="1">MSERSRSLAGMQEKLSKMEGTQRSFTNLVILLASFGMLALTVWLYGKGKIGFEGILTCTIAMMGSFGPVVALSSLSNNLNQTLASGERVLSLLEETPMVEEISGNVDIRNQNNSPEKEKYILRGILTGRAKNSVKAFSGAEAQHVTFAYENETILDDYSLKLESGKITGIHGASGSGKSTLLKLLMRFWDVNQGSVSVDGEDVRKIPTRHLRDMESYVTQETHLFHDSIANNIAVGSPAASREAIIEAAKKASIHDFIMKLPKGYDTEVGELGDTLSGGEKQRIGIARAFLHDSPLILMDEPTSNLDSLNEGIILKSLREAAEKKTVVLVSHRKSTMNITDTVFEMKNGRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B1P1</accession>
    <name>A0A174B1P1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Modification target Cys-rich repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94792">
        <property type="protein sequence ID" value="CUN94792"/>
        <property type="gene ID" value="ERS852478_01460"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026393">
        <property type="entry name" value="tSAM_targ_Cxxx_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04114">
        <property type="entry name" value="tSAM_targ_Cxxx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018087" evidence="1">
        <location>
            <begin position="22"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN94792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="262" mass="25612" checksum="6126AB9F186CBA90" modified="2016-09-07" version="1">MACSKGCGTSCATSCKSTASGNCGGCGTSCSRNCSTICSGTCSGTCNKTCTKQCNHNCSDECTGCQRTCADDCEAGCKTDCLQTCTANCSDTCADCTGGCGNSCFATCADDCTGGCKGGCNTTCTANCMNDCNTWCEGGCYSSCTWTCEGCSNTCTGTCSGTCSGTCSGTCSGTCQGCDNKCTASCAQSCTGCSGCSGCGNSCGSGCTDSCMGTCKSNCSGGCGTSCGGCSTSCASSCQSDCGGTCRNQCYGQATTPIYSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B365</accession>
    <name>A0A174B365_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable endonuclease 4</fullName>
            <ecNumber evidence="9">3.1.21.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nfo_2</name>
        <name evidence="9" type="ORF">ERS852478_01482</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95521">
        <property type="protein sequence ID" value="CUN95521"/>
        <property type="gene ID" value="ERS852478_01482"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="8">
        <location>
            <begin position="5"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN95521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="190" mass="21388" checksum="6A70839A8910AD80" modified="2016-09-07" version="1">MADDLRRLEMTPGNYYNFHPGSHVGQGAEVGISKIAEILNEVLTKDQSTIVLLETMSGKGTEVGRNFEELRQIIDRVELKDKLGVCLDTCHVWDGGYDIVNDLDSVFEEFDRIIGLDRLKAIHLNDSMNPLGSHKDRHARIGEGEIGLEALVRVINHPATEGIPFILETPNDDEGWTHEIALLRNEYKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B3F4</accession>
    <name>A0A174B3F4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200107.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94933">
        <property type="protein sequence ID" value="CUN94933"/>
        <property type="gene ID" value="ERS852478_01464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN94933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="760" mass="81911" checksum="A7F2D47F846B2AB4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B916</accession>
    <name>A0A174B916_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97277">
        <property type="protein sequence ID" value="CUN97277"/>
        <property type="gene ID" value="ERS852478_01529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045798">
        <property type="entry name" value="TrbL_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19478">
        <property type="entry name" value="TrbL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN97277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="234" mass="25654" checksum="B2467118D0F480DF" modified="2016-09-07" version="1">MLQNLSETVIVPIAAAILALVMCYELIDMIVEKNNMHDFDSSMFFRWIFKSAFAILIVTNTWNIVMGVFDATQQVVNQSAGVIIGDTSIDFDTLLPDLESRLEAMDIGPLLGLWFQTLVVGPTMNILSICIFLVTYGRMIEIYAVTALGPIPLATLGNAEWRGMGQNYLKSLLALGFQAFLIMVVVGIYAVLIQQIGTADDISGAIWGCMGYTVLLCFCLFKTGSISKAVFTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B9D8</accession>
    <name>A0A174B9D8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6017 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200122.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97063">
        <property type="protein sequence ID" value="CUN97063"/>
        <property type="gene ID" value="ERS852478_01523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046059">
        <property type="entry name" value="DUF6017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19481">
        <property type="entry name" value="DUF6017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6017" evidence="2">
        <location>
            <begin position="228"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN97063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="381" mass="42883" checksum="AFA18EB1B7B91338" modified="2016-09-07" version="1">MYFTSGSDRAFEQLMQTRPGADHFDSGEAGAPEGCGTCRFYRPHWKYQFCVYEECPYQPGKLTALDGAVKFQVKGVDDEMAVFRVEKNRGYTVMSNHHLRNKDLSLKAKGLLSQMLSLPEDWDFTLKGLSLINREQIDAIRAAVRELEQAGYIVRSRERDSQGRLRGADYIIYEQPQPVPDSPTLENPTLDNPTQEKPTQEKPTQLNKDRSSKEKSITDGSNTDSIPILSPPSPLGEEAAAPPERKGTGAKSQSAVEIYREIIKDNIEYEHLCQYAKGIDRDMLDEIVDLLVETVCSARKTIRIAGDDYPAELVKSKLMKLNSSHIEFVFDCISKNTTEIRNIKKYLLAVLFNAPSTINGYYTALVAHDMNTGSWGTPQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BKP3</accession>
    <name>A0A174BKP3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Linear gramicidin dehydrogenase LgrE</fullName>
            <ecNumber evidence="3">1.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lgrE_2</name>
        <name evidence="3" type="ORF">ERS852478_01613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057323.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01133">
        <property type="protein sequence ID" value="CUO01133"/>
        <property type="gene ID" value="ERS852478_01613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="PTHR11487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO01133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="250" mass="29360" checksum="EE02BAC8129D695A" modified="2016-09-07" version="1">MYDNKWIAHGRMSEENKINLLCFSYPGGSASNFATWKKLIDSRINLLPILYPERELRKNDPMEENFELFVDDFINENKELFSVPYAFFGYCGGAVLAYEISAKVKKVYDREPIAGFIASSESPEYLKGSILEFPAEGTREDVIEYLLRLEMFDEAIVKNKVFLDYYIPMLRADCNMLATYQYRSHERMSCDFDIWYGKEDKNIHREKIEKWRECTNGNVKIEEMAGGHFFVDIEKQCICEMINQKLLEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BS29</accession>
    <name>A0A174BS29_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cell division protein WhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">whiA</name>
        <name evidence="9" type="ORF">BWLFYP14_00251</name>
        <name evidence="8" type="ORF">ERS852478_01653</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cell division and chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WhiA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02448">
        <property type="protein sequence ID" value="CUO02448"/>
        <property type="gene ID" value="ERS852478_01653"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01420">
        <property type="entry name" value="HTH_type_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018478">
        <property type="entry name" value="Sporu_reg_WhiA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10298">
        <property type="entry name" value="WhiA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="SSF55608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WhiA_N" evidence="6">
        <location>
            <begin position="37"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="LAGLIDADG_WhiA" evidence="7">
        <location>
            <begin position="147"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_WhiA" evidence="5">
        <location>
            <begin position="241"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO02448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX67410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="336" mass="38017" checksum="11EA3D5D408430FA" modified="2016-09-07" version="1">MHRKTDWSENRKDDKGEMSFSGMVKEELSRQIGLARHCKMAELAAILCSCGKMECFSGDSKLKIQTENEAVARKCFTLLQKTFNIETKIFVRENSHLKRVKVYTIEITDPEEIQVIFQALRLVTNSIDQGTLVLSDMLVVQQNCCKRAFIRGAFLASGSISDPEKGYHFEIVCSDAKRAEQLQTIIRSFSVDAKIVQRKKSHVVYVKEGAQIVDMLAVMEANVALMDLENIRILKEMRNSVNRKVNCETANINKTVNAAVKQMEDIKLVRQKIGFEQLNEGLAQVAELRMQYPEATLKELGMMLSPQVGKSGVNHRLRKLSAMADELREKQGGELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BTD0</accession>
    <name>A0A174BTD0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">infA</name>
        <name evidence="9" type="ORF">BWLFYP14_00278</name>
        <name evidence="5" type="ORF">ERS852478_01680</name>
        <name evidence="6" type="ORF">ERS852523_01272</name>
        <name evidence="8" type="ORF">GT712_08875</name>
        <name evidence="7" type="ORF">GT728_04805</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP32974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005428560.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2961"/>
    <dbReference type="EnsemblBacteria" id="CUO03419">
        <property type="protein sequence ID" value="CUO03419"/>
        <property type="gene ID" value="ERS852478_01680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP32974">
        <property type="protein sequence ID" value="CUP32974"/>
        <property type="gene ID" value="ERS852523_01272"/>
    </dbReference>
    <dbReference type="GeneID" id="61848994"/>
    <dbReference type="GeneID" id="67479996"/>
    <dbReference type="eggNOG" id="COG0361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO03419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP32974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL32539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS89180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX67437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="72" mass="8232" checksum="4FB21851AC06A807" modified="2016-09-07" version="1">MSKADVIEVEGTVLEKLPNAMFKVELENKHVVLAHISGKLRMNFIRILPGDKVTIELSPYDLSKGRIIWRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C0Z6</accession>
    <name>A0A174C0Z6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-type ATP synthase beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">V-ATPase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ntpB</name>
        <name evidence="4" type="synonym">atpB</name>
        <name evidence="9" type="ORF">BWLFYP14_01155</name>
        <name evidence="7" type="ORF">ERS852478_01719</name>
        <name evidence="8" type="ORF">GT712_12255</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705343.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05438">
        <property type="protein sequence ID" value="CUO05438"/>
        <property type="gene ID" value="ERS852478_01719"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="6">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="5">
        <location>
            <begin position="131"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO05438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS89825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX63796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="460" mass="50697" checksum="EC1A633867C9AFB1" modified="2016-09-07" version="1">MAIEYLGLSEINGPLVVLEGVKNASYEEIVEFHMDDGTRKIGRIIEIYEDKAVIQVFEGTDGMSLGNTHTRLTGRPMEIGLSPEILGRTFNGIGQPIDGLGDITPDVKLNINGLPLNPVAREYPRNYINTGISAIDGLTTLIRGQKLPIFSGNGLPHDKLAAQIVQQASLGEDSDEDFAIVFAAMGVKYDVAEFFRRTFEESGAADHVVMFLNLANDPVVERLLTPKIALTAAEYLAFEKGMHILVILTDITSFCEAMREVSSSKGEIPSRKGYPGYLYSELATLYERAGIVKGKPGSVTQIPILTMPNDDITHPIPDLTGYITEGQIVLDRQLHGQAIYPPINVLPSLSRLMKDGIGEGYTRADHQDVANQLFSCYAKVGDARALASVIGEDELSPLDKRYLVFGKAFESEFVGQSETENRSITETLDKGWELLGLLPKEELDRIDTKILDKYYHETVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C1T3</accession>
    <name>A0A174C1T3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">General stress protein 16U</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yceD_2</name>
        <name evidence="3" type="ORF">ERS852478_01727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAPAB/TerDEXZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200189.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05718">
        <property type="protein sequence ID" value="CUO05718"/>
        <property type="gene ID" value="ERS852478_01727"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO05718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="193" mass="21124" checksum="52B249636A206D8C" modified="2016-09-07" version="1">MPINLSKGQKVDLTKKNPGLKKIMVGLGWDVNAFDSGVDFDLDAAAFMLGANGKCPTEKEFIFYGNLKHASESVIHMGDNLTGEGEGDDEQIMIDLSKVPANIERIAFTVTIYDAEARRQNFGQVSNSYIRLVDESNEVELIHYDLGEDFSIETAVVVGELYRHNGEWKFNAIGSGFQGGLAALCGHYGIEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C926</accession>
    <name>A0A174C926_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="8">3.5.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nagA_2</name>
        <name evidence="8" type="ORF">ERS852478_01808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200286.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08248">
        <property type="protein sequence ID" value="CUO08248"/>
        <property type="gene ID" value="ERS852478_01808"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047419">
        <property type="term" value="F:N-acetylgalactosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="7">
        <location>
            <begin position="46"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO08248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="382" mass="41417" checksum="01C2AD69139A2448" modified="2016-09-07" version="1">MSIRIINGKVYKNGAFSEEEIVLKEGKIVSAQDGDAEEVYDAKGNYVVPGFIDVHTHGGAGVDVNAADQQGFEKIGHFFATQGTTSWLSSILTDTKEQTLKTIKEAVKHQEAQKNGHENCADLLGIHLEGPFLSPEYKGAMPEHLLISPDLDLLKEYQEAAGGNIRYITVSPEVKGVPESIKGMIDLGMKVAIGHSGADYETAWKCINEGAVSATHTFNAMKLLHQHFPAIMGAVLESDIYCEAICDGRHLHPGTVRFLLKMKGLDKVIAITDSIMAAGLPDGEYMLGVNPVIVKDGDAKLKYGDSRAGSTLTTGCALKNLIKFTGRPLEEILPLLTCNPAKMLDVYDRIGSLDTGKDADVVILDKEYSVVDTFVKGRKIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CKX4</accession>
    <name>A0A174CKX4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703605.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13744">
        <property type="protein sequence ID" value="CUO13744"/>
        <property type="gene ID" value="ERS852478_01960"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019271" evidence="2">
        <location>
            <begin position="26"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO13744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="280" mass="30882" checksum="851814C5D4DF4FA5" modified="2016-09-07" version="1">MKTKFMTLMTVATLGIFSAATVMAAGNNDFYTQPPAGSEWEKADTEGTYASYTNGNDYVNIYKYSLEDVKTGIAKCNDTYDACYQTIYSEGNSLYMAVGYAKDADDISDVRKFVEYISYPGNPSLTRQENENQTDDSSDDSDKATTDTASQKSGGDSDILTTSPMTLVDSDGNTIEINYILHKDYSCEYRGDDGMNYTDNGDETYTDENGNTYSALNDDTHHLGYTLEQHDLQDANGNTVTVTETTNGDYYFQDENGTGFTDNGDGTWSDENGSSYTEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CR04</accession>
    <name>A0A174CR04_9FIRM</name>
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        <submittedName>
            <fullName evidence="5">Manganese transport protein MntH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BWLFYP14_00421</name>
        <name evidence="5" type="ORF">ERS852478_02001</name>
        <name evidence="6" type="ORF">ERS852523_00082</name>
        <name evidence="7" type="ORF">GT728_08925</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
            <strain evidence="6 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CUO15782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZL33315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2247"/>
    <dbReference type="EnsemblBacteria" id="CUO15782">
        <property type="protein sequence ID" value="CUO15782"/>
        <property type="gene ID" value="ERS852478_02001"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96317">
        <property type="protein sequence ID" value="CUO96317"/>
        <property type="gene ID" value="ERS852523_00082"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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            <end position="249"/>
        </location>
    </feature>
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            <end position="299"/>
        </location>
    </feature>
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            <end position="328"/>
        </location>
    </feature>
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            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO15782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO96317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX62324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="400" mass="41441" checksum="AF893430D18B1124" modified="2016-09-07" version="1">MSEKKKSGGALLGAAFLMATSAIGPGFLTQTATFTGQYQESFGFVILVSVILAAIAQLNIWRVLCVTGLRGQDVSNKVLPGLGYLVSILIVFGGLVFNIGNVGGGALGFNTLLGIPTKVGYILAGLLAILVFVLKNAKSAMDTITKVLGAIMIIVIFVVIIVVKPPVGSALKNTFVPEAGATNLIPAILTLLGGTVGGYITFSGAHRLIDAGITGEKNLKEINKSSVMGMIIATIVRIFLFLAVLGVVVKGVTLDAANPAADAFKQGAGEIGYRFAGLVLLCAAITSIIGAAYTSVSFLKTFSKSIEENENKVIIGFIIISTAIMFILGNPAVLLVLAGAVNGLILPITLAICLIAAHKKSIMGENYHHPVVLTILGVIVVILTAYLGVTTFVSKIGTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CTQ2</accession>
    <name>A0A174CTQ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Aliphatic sulfonates import ATP-binding protein SsuB</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ssuB_2</name>
        <name evidence="5" type="ORF">ERS852478_01981</name>
        <name evidence="6" type="ORF">GT728_09025</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707519.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15135">
        <property type="protein sequence ID" value="CUO15135"/>
        <property type="gene ID" value="ERS852478_01981"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO15135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL33335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="255" mass="28478" checksum="F75FC7807BE54608" modified="2016-09-07" version="1">MKPLLDITDVSLSYHSLSGETPALSHISFQLMPGEFLAIVGPSGCGKSTLLNLICGLLRPEQGQILLDGTPVTSGDCRIGYMLQKDHLLEWRTIYKNVLLGLEIRRELTAEKLAYVNQLLSDYGLDKFRSAHPSELSGGMRQRAALIRTLALKPELLLLDEPFSALDSQTRLSVSDDIGKILRQEKKTAILVTHDISEAISMADRVIILSPRPAIIRKIVPVCFDLENRTPMASRNAPEFKSYFNLIWKELNHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CUX5</accession>
    <name>A0A174CUX5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M16C associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200475.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15899">
        <property type="protein sequence ID" value="CUO15899"/>
        <property type="gene ID" value="ERS852478_02005"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M16C_associated" evidence="1">
        <location>
            <begin position="462"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO15899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="974" mass="110340" checksum="00752A6363636771" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D031</accession>
    <name>A0A174D031_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">sigA</name>
        <name evidence="11" type="synonym">rpoD</name>
        <name evidence="13" type="ORF">BWLFYP14_02393</name>
        <name evidence="9" type="ORF">ERS852478_02052</name>
        <name evidence="10" type="ORF">ERS852523_00037</name>
        <name evidence="12" type="ORF">GT712_14055</name>
        <name evidence="11" type="ORF">GT728_13760</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO95248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000035">
        <property type="protein sequence ID" value="MZL34242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000030">
        <property type="protein sequence ID" value="MZS90164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX66022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707631.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2206"/>
    <dbReference type="EnsemblBacteria" id="CUO17390">
        <property type="protein sequence ID" value="CUO17390"/>
        <property type="gene ID" value="ERS852478_02052"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95248">
        <property type="protein sequence ID" value="CUO95248"/>
        <property type="gene ID" value="ERS852523_00037"/>
    </dbReference>
    <dbReference type="GeneID" id="66492646"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042189">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="6">
        <location>
            <begin position="142"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="6">
        <location>
            <begin position="221"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="6">
        <location>
            <begin position="310"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="6">
        <location>
            <begin position="166"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO17390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO95248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL34242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS90164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX66022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="375" mass="43174" checksum="8C272601A97CBB3D" modified="2016-09-07" version="1">MEMNMGKFSEKLVELLELAKKKKNVLEYQEINDFFKDQPLGVEQMEKVFDFLEASGVDVLRITDSNADDMILDDDDADIDKLDEEEIELDKIDLSVPEGVSIEDPVRMYLKEIGKVPLLSAEEEIELAKRMENGDEAAKKRLAEANLRLVVSIAKRYVGRGMLFLDLIQEGNLGLIKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVETINKLIRVSRQLLQELGREPTPEEIAKEMDMSVERVREILKISQEPVSLETPIGEEEDSHLGDFIQDDNVPVPADAAAFTLLKEQLVEVLSTLTDREQKVLRLRFGLDDGRARTLEEVGKEFNVTRERIRQIEAKALRKLRHPSRSRKLKDYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DBI3</accession>
    <name>A0A174DBI3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conjugative transposon protein TcpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200591.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21355">
        <property type="protein sequence ID" value="CUO21355"/>
        <property type="gene ID" value="ERS852478_02158"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z8HY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16428">
        <property type="entry name" value="TcpC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024735">
        <property type="entry name" value="TcpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035628">
        <property type="entry name" value="TcpC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12642">
        <property type="entry name" value="TpcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO21355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="300" mass="33949" checksum="5104BA984D1B2312" modified="2016-09-07" version="1">MFKKKEKTEKAPKNKKVRIMKVGTHKKSVLLLWVVLLASTSFGVYKNFTAIDTHTVHEKEIIQLRLNDTNGIENFVKNFAKAYYSWDTSKEAIEARTTEISKYLTKELQDLNADTIRTDIPTSVTVTNVLVWNVEQSGTDDFTVAYEVDQQVKEGEQTQAVTENYTVTVHVDKDGAMVITQNPTLAPAVQKSKYEPKTQVADVSVSSDTVKDATAFLETFFKLYPTATEKELAYYVKDGVLAPVSGDYVFSELENPVFTKDGDNLKVSVSVKYLDNKSKMTQISQYELVLHKDDNWKIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DFB4</accession>
    <name>A0A174DFB4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">pyrC</name>
        <name evidence="9" type="ORF">BWLFYP14_01489</name>
        <name evidence="7" type="ORF">ERS852478_02236</name>
        <name evidence="8" type="ORF">GT712_11675</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000022">
        <property type="protein sequence ID" value="MZS89714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705497.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24301">
        <property type="protein sequence ID" value="CUO24301"/>
        <property type="gene ID" value="ERS852478_02236"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="53"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="326"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO24301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS89714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX64636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="428" mass="46461" checksum="8FEA01E5B47BD78C" modified="2016-09-07" version="1">MGILIQGGRIVDAATDTDKKGDIYLEDGVITEIGEKLKIKDKSDKVIDAKGCLVMPGLIDLHVHFRDPGQTQKEDIETGSRAAARGGVTTVVAMPNTTPVIDSPDRVNYVHNKAKQLAGIHVLQAGAITQGEKGQELSDIEGMVKAGIPALSEDGKSVMNTRLCKEAMEVAEKFNVPIFAHCEDIDLRGDGCMNEDENARRLGLPGICNAVEDVIAARDILLARETGARLHLCHCSTEGVAKMMEIVKEEGLDNITAEVCPHHFILTSDDIKCDDPNYKMNPPLRTKKDVDALIRGLKDGSFKVISTDHAPHAVPEKTGSIRNAAFGIVGIETSFALSYTALVETGILTISQLIEKMSWNPAQILGSDRGTLQKGHPADIVIADIDHEYKIDKNEFASKGRNTPFDGWKVKGKILYTICDGKVVYQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DM16</accession>
    <name>A0A174DM16_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH-quinone oxidoreductase subunit J</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Nitrogen fixation protein rnfC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnfC_3</name>
        <name evidence="12" type="synonym">rnfC_2</name>
        <name evidence="11" type="ORF">ERS852478_02312</name>
        <name evidence="12" type="ORF">ERS852523_01629</name>
        <name evidence="14" type="ORF">GT712_12800</name>
        <name evidence="13" type="ORF">GT728_12235</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">2789STDY5834863</strain>
            <strain evidence="12 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="13 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 18">BIOML-A1</strain>
            <strain evidence="14 17">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP44138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000029">
        <property type="protein sequence ID" value="MZL33947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381347.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000086_gene4011"/>
    <dbReference type="EnsemblBacteria" id="CUO26621">
        <property type="protein sequence ID" value="CUO26621"/>
        <property type="gene ID" value="ERS852478_02312"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP44138">
        <property type="protein sequence ID" value="CUP44138"/>
        <property type="gene ID" value="ERS852523_01629"/>
    </dbReference>
    <dbReference type="GeneID" id="66494429"/>
    <dbReference type="eggNOG" id="COG4656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010208">
        <property type="entry name" value="Ion_transpt_RnfC/RsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017054">
        <property type="entry name" value="PduS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026902">
        <property type="entry name" value="RnfC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43034">
        <property type="entry name" value="PTHR43034"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13375">
        <property type="entry name" value="RnfC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036408">
        <property type="entry name" value="PduS_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="290"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO26621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP44138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL33947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS89926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="442" mass="48428" checksum="9132765086BB6A35" modified="2016-09-07" version="1">MEIKELQDIIQQNGVVGAGGAGFPTYMKLTDKANTILMNCAECEPLLKLHRQLLEKHAYEIMKTFHMIQETVGASEAIIGIKKSYVQTIHALNQHIEEFPGMRLHLLDEVYPMGDEVVLIYEATGRVVRPGGLPIEQGVAVFNVETVYNVYRAVEEKQPVTDKYVSVVAEVSDPVTVRVPLGCTLEEVVAQAGSTTVKDPVYFVGGPMMGRIGNGSDPVTKTTNAILVLPKDHLIVAKKQRTSSIDLKRAASICCQCNTCTDLCPRHNLGHPIDPAKFMRAASNNDFRDLNPYIDASFCSSCGVCEMYSCPQSLAPRSLLADMKGGLRKAGIRPPQGVQPKPVQESREYRKVPEERLMARLGLTRYDKDAPLKEELVQVKKVRILLSQHIGAPAQAVVKAGDEVTRGQMIAQPAQGLSVGIHASVSGKVTEVTDRYIIIAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E395</accession>
    <name>A0A174E395_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cobalt-precorrin-5B C(1)-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.195</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cobalt-precorrin-6A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">cbiD</name>
        <name evidence="8" type="ORF">BWLFYP14_00104</name>
        <name evidence="6" type="ORF">ERS852478_02432</name>
        <name evidence="7" type="ORF">GT728_01840</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:26285"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:60063"/>
            <dbReference type="ChEBI" id="CHEBI:60064"/>
            <dbReference type="EC" id="2.1.1.195"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CbiD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.195" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL31975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057526.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30978">
        <property type="protein sequence ID" value="CUO30978"/>
        <property type="gene ID" value="ERS852478_02432"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1903">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046140">
        <property type="term" value="P:corrin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00787">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002748">
        <property type="entry name" value="CbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036074">
        <property type="entry name" value="CbiD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35863">
        <property type="entry name" value="PTHR35863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01888">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026782">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111342">
        <property type="entry name" value="SSF111342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00312">
        <property type="entry name" value="cbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO30978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL31975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="386" mass="41850" checksum="182236FEAA29A7FB" modified="2016-09-07" version="1">MKNGLEDYYVIRGNKKMRFGYTTGSCAAAACKGAAEILLGGVMHKAVTLMTPKGILLTLELKDIRIEGNQVTCAIQKDAGDDPDTTNGILVYATVQKTKEPGIILDGGVGVGRVTKAGLSQKIGEAAINPVPKAMILREATEIAEKYDYEGGLKIIISVPEGVEIAKKTFNPRLGIVGGISILGTSGIVEPMSEAALVQSINVEMKQHFSQGEEYLLVTPGNYGADYLREHMDLPYEKNIKCSNYVGETIDMAIDMGVKGILFIAHIGKFVKVAAGIMNTHSHSADARMEVLASNAIRAGASLECAKEILNASTTDEAIDILEKYQILQKTMKEILDRIQFYLNHRSYEQILLGAVIFNNTYGYLGQTADAEKLIKLINAQNDEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E7W8</accession>
    <name>A0A174E7W8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TIGR04086 family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02525</name>
        <name evidence="3" type="ORF">GT728_13360</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000033">
        <property type="protein sequence ID" value="MZL34164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703735.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33914">
        <property type="protein sequence ID" value="CUO33914"/>
        <property type="gene ID" value="ERS852478_02525"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YJ5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023804">
        <property type="entry name" value="DUF3792_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12670">
        <property type="entry name" value="DUF3792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04086">
        <property type="entry name" value="TIGR04086_membr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO33914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="116" mass="12281" checksum="180FEC472C5FBE49" modified="2016-09-07" version="1">MKVRAILKSLLFAYALTGVALLLLALVLFAFDLGETAVDAGIIIIYVLACFMGGFMAGKIVRKDKYLWGVITGLAYYVLLLTVSVMAKGGWDMSAAHAVTTFFMCTGGGTLGGMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E8Q6</accession>
    <name>A0A174E8Q6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor CnrH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cnrH</name>
        <name evidence="4" type="ORF">ERS852478_02483</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32839">
        <property type="protein sequence ID" value="CUO32839"/>
        <property type="gene ID" value="ERS852478_02483"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="19"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="109"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO32839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="163" mass="19344" checksum="0F5B4E3019EC518F" modified="2016-09-07" version="1">MDALITEAKNGDKEAFVRLIRMNKQSLYKTAWIYLRDEQDIADALQNTILSCYENIQRLRESKYFKTWLMRILINECKDILRQKNHAAELDDFAEGVHCEELNLCEWKQLLLCLDEESRKIVELYYFDEFSVKEISALLEMNSNTVSTKLSRARAKLKKVIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E8R1</accession>
    <name>A0A174E8R1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Excisionase from transposon Tn916</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO34242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200770.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34242">
        <property type="protein sequence ID" value="CUO34242"/>
        <property type="gene ID" value="ERS852478_02536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038148">
        <property type="entry name" value="Tn1545/Tn916_Xis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015122">
        <property type="entry name" value="Tn916-Xis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09035">
        <property type="entry name" value="Tn916-Xis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO34242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="68" mass="7936" checksum="80D4A67F89C976BF" modified="2016-09-07" version="1">MNNETQVQIQNKFCLTIDEAVIYFNIGEKKLRKLVADNLDSGFIIQNGVKFLIKRKRFEDFLNDLTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EEQ5</accession>
    <name>A0A174EEQ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO34919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200781.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34919">
        <property type="protein sequence ID" value="CUO34919"/>
        <property type="gene ID" value="ERS852478_02542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO34919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="139" mass="17189" checksum="67D0C97CD8E23180" modified="2016-09-07" version="1">MNEREKIIRLWFDMWLKQQDLGIDKIFTEDVVYTESWCPKYENLKTVKHWFNEWNTRGKVIIWDIKQFFHKENQTVVEWYFKNEMNTGSVEEFDGISLIEWTEDNKIKSLKEYGCNLNNYNPYQHSDNPQFRNEKISWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EKG7</accession>
    <name>A0A174EKG7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prs_2</name>
        <name evidence="7" type="synonym">prs</name>
        <name evidence="8" type="ORF">BWLFYP14_02462</name>
        <name evidence="6" type="ORF">ERS852478_02594</name>
        <name evidence="7" type="ORF">GT728_02715</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000050">
        <property type="protein sequence ID" value="VUX66090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994041.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36450">
        <property type="protein sequence ID" value="CUO36450"/>
        <property type="gene ID" value="ERS852478_02594"/>
    </dbReference>
    <dbReference type="GeneID" id="66494119"/>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="5">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="211"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO36450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL32131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="389" mass="44374" checksum="8EA83BCA4087D758" modified="2016-09-07" version="1">MPNIELLEKSMPVAPIRIAALGCRELAEEVDRKLVKFRKELVERKQLSVIPQGYSEESFIVECECPRFGTGEGKGYIKESVRGTDLYIMVDVTNYSESYTVCGHENHMSPDNHFQDLKRIISAATGKAHRINVIMPFLYEGRQHRRTKRESLDCALALKELSDMGVSNIITFDAHDPRVQNSIPLNGFDNFFPTYQFLKALIKSVPDLRVDNDHLMIISPDEGAMSRAVYFSNILGVDMGMFYKRRDYSTIVNGKNPIVAHEFLGDSVEGKDVVVIDDMISSGGSMLDVAKQLKERNAKRVFVCTTYGLFTDGLDKFDEYYEKGWLDRVITTNLNYRIPELLERPYYVEANMSKYLASIIDIINHDVSVEKVRSSNEKIMSLMEKVNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EKL8</accession>
    <name>A0A174EKL8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA interferase</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ndoA_2</name>
        <name evidence="5" type="synonym">ndoA</name>
        <name evidence="8" type="synonym">ndoA_1</name>
        <name evidence="8" type="ORF">BWLFYP14_01464</name>
        <name evidence="4" type="ORF">ERS852478_02613</name>
        <name evidence="5" type="ORF">ERS852523_00210</name>
        <name evidence="7" type="ORF">GT712_07435</name>
        <name evidence="6" type="ORF">GT728_02835</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">2789STDY5834863</strain>
            <strain evidence="5 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 13">BIOML-A1</strain>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PemK/MazF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000002">
        <property type="protein sequence ID" value="CUP00308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000011">
        <property type="protein sequence ID" value="MZS88903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000033">
        <property type="protein sequence ID" value="VUX64610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994045.1">
        <property type="nucleotide sequence ID" value="NZ_JADPFJ010000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000003_gene1627"/>
    <dbReference type="EnsemblBacteria" id="CUO36949">
        <property type="protein sequence ID" value="CUO36949"/>
        <property type="gene ID" value="ERS852478_02613"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00308">
        <property type="protein sequence ID" value="CUP00308"/>
        <property type="gene ID" value="ERS852523_00210"/>
    </dbReference>
    <dbReference type="GeneID" id="66494101"/>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO36949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP00308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL32155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS88903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX64610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="115" mass="12931" checksum="27BE324F22EC9A81" modified="2016-09-07" version="1">MVIKRGDIFYADLRPVVGSEQGGIRPVLIIQNNVGNRHSPTVICAAITSKMNKAKLPTHIEINAELYGIEKDSVILLEQLRTIDKRRLKDKVCHLDDAMLDKVNHALEISLELTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EKW1</accession>
    <name>A0A174EKW1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_02630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO37877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060107.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000075.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37877">
        <property type="protein sequence ID" value="CUO37877"/>
        <property type="gene ID" value="ERS852478_02630"/>
    </dbReference>
    <dbReference type="GeneID" id="66492723"/>
    <dbReference type="eggNOG" id="COG2768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO37877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="374" mass="40604" checksum="C6F95FF0769FEA5A" modified="2016-09-07" version="1">MEKSTVYFTDFRCPVGTSQLDKLKKLCVTAGIKDIDMDGKFVAIKMHFGELGNLAFLRPNYAKAVADLCKEQGGLPFLTDCNTLYPGSRKNALEHLECANLNGFNSISTGCQIIIGDGLRGTDEVEVPVVNGEYCQTALIGHAIMDADIFISLSHFKGHEATGFGGALKNIGMGCGSRAGKMKQHASGKPAVNEELCRGCRRCAKECGSDAITYPNKKAVIDYDKCKGCGRCIGACGFDAVYNPNSSANELLDRKMAEYAQAVCHGRPHFHVALVQDISPNCDCHGENDAPILPDIGMFASFDPVALDQACADACLKATPIENSQLGEHLAKPDWHCHHDHFKDSNPNIEWQATLDQAEKIGLGTRQYELKIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ELL9</accession>
    <name>A0A174ELL9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage V sporulation protein T</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spoVT</name>
        <name evidence="3" type="ORF">ERS852478_02665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060116.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38932">
        <property type="protein sequence ID" value="CUO38932"/>
        <property type="gene ID" value="ERS852478_02665"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014213">
        <property type="entry name" value="SpoVT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026579">
        <property type="entry name" value="Spore_V_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02851">
        <property type="entry name" value="spore_V_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO38932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="182" mass="20037" checksum="6349AE8449426144" modified="2016-09-07" version="1">MKATGIVRRIDDLGRVVIPKEIRKTLRIKEGTPLEIFTDREGEIILKKYSPIGELNVFAKEYAEALAQSSGMVACITDHDQVVAAAGQGSREYVGKPISKALEDAITERSSVFANGNDRSRIPVTQEQREPLYSQIMQPIISAGDTVGSVLLLGKNERDVMGESEKMLIRTASGFLGRQMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EY20</accession>
    <name>A0A174EY20_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379854.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42207">
        <property type="protein sequence ID" value="CUO42207"/>
        <property type="gene ID" value="ERS852478_02762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO42207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="210" mass="24470" checksum="C1E76360745AA823" modified="2016-09-07" version="1">MPNKLPRFFDNHKICIICEGNEEYEYLNRLKNLKVWNEQYDISLVNAGGNGNIPARYQDRYQNGADKLVLVFCDTEKKPHEQYEDIKRKINEFHGVDSAANEVIMFGNPCTMQIISKHWTDENLKSPAKPVNAPLIKKYTRVENYKGRADQIEEVMEYVTVENYKDMSRRVKDLDSDDSVTGSSNFGKFIKLFESDDSGWIDKINRNLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZ44</accession>
    <name>A0A174EZ44_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01081</name>
        <name evidence="1" type="ORF">ERS852478_02771</name>
        <name evidence="2" type="ORF">ERS852523_02220</name>
        <name evidence="4" type="ORF">GT712_06925</name>
        <name evidence="3" type="ORF">GT728_15770</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000022">
        <property type="protein sequence ID" value="CUP61865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000046">
        <property type="protein sequence ID" value="MZL34612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000010">
        <property type="protein sequence ID" value="MZS88808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705279.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000048_gene1276"/>
    <dbReference type="EnsemblBacteria" id="CUO42557">
        <property type="protein sequence ID" value="CUO42557"/>
        <property type="gene ID" value="ERS852478_02771"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP61865">
        <property type="protein sequence ID" value="CUP61865"/>
        <property type="gene ID" value="ERS852523_02220"/>
    </dbReference>
    <dbReference type="GeneID" id="66494838"/>
    <dbReference type="eggNOG" id="ENOG5032VB8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO42557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP61865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX63723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="89" mass="10158" checksum="14743465E9BB8B1D" modified="2016-09-07" version="1">MYYVPDGTKECGYYECKKCGNRFLSMQTMKRIPCPDCEAEIDYEIGPDESLEDVLDTAELIQKIEGEEEVEKMDTLLSLALTGGDYSWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F0A9</accession>
    <name>A0A174F0A9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_02793</name>
        <name evidence="7" type="ORF">GT712_07065</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
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        <property type="protein sequence ID" value="CUO43141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000010">
        <property type="protein sequence ID" value="MZS88836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_WWVH01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43141">
        <property type="protein sequence ID" value="CUO43141"/>
        <property type="gene ID" value="ERS852478_02793"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="438"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO43141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS88836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="537" mass="62138" checksum="2441E1B7707056E5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F1V0</accession>
    <name>A0A174F1V0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO44044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44044">
        <property type="protein sequence ID" value="CUO44044"/>
        <property type="gene ID" value="ERS852478_02826"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO44044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="41" mass="4866" checksum="D60E0B5C48A838B4" modified="2016-09-07" version="1">MPMTPNTEQDWKAWRNLMWSEILTESVKSYMDCKCLNAISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F7F9</accession>
    <name>A0A174F7F9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">sn-glycerol-3-phosphate transport system permease protein ugpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ugpA_7</name>
        <name evidence="7" type="ORF">ERS852478_02847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379913.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44848">
        <property type="protein sequence ID" value="CUO44848"/>
        <property type="gene ID" value="ERS852478_02847"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="67"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO44848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="285" mass="31794" checksum="EE92ADBB3306A5B1" modified="2016-09-07" version="1">MKKLKNTGAYAYLFPSFLIFGIFLFYPFFKTLYLSLFKTNKMGQAKLFVGLGNYKELLQSSSFWNSLAVTLIFVVIVVAVSMILGLTTAVLCNKTFPGIRFFSTAYALPMAIASSSAAMIFKIMLHPSVGIINKIFHLDINWVSDPKYALICVAVLTAWLNSGINFLYFSAGLSNIDETIYERASVDGASSFQKFYRLTLPGLAPMMFYTLVVNIIQAFQSFGQVKILTQGGPGESTNLIVYSIYRDAFFNYRFGSAAAQSVVLFLIVLVLTLVMFKIEKKGVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F8I0</accession>
    <name>A0A174F8I0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE</name>
        <name evidence="10" type="ORF">ERS852478_02852</name>
        <name evidence="12" type="ORF">GT712_17560</name>
        <name evidence="11" type="ORF">GT728_14440</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">BIOML-A1</strain>
            <strain evidence="12 14">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000038">
        <property type="protein sequence ID" value="MZL34365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000052">
        <property type="protein sequence ID" value="MZS90815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380560.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44989">
        <property type="protein sequence ID" value="CUO44989"/>
        <property type="gene ID" value="ERS852478_02852"/>
    </dbReference>
    <dbReference type="GeneID" id="66494761"/>
    <dbReference type="eggNOG" id="COG1087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="9">
        <location>
            <begin position="4"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO44989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL34365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS90815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="338" mass="37139" checksum="BD3560F1DA4ED310" modified="2016-09-07" version="1">MAILVTGGAGYIGSHTVVELQNAGYDVVVLDNLSNASEKSLERVSKITGKPVKFYKADILDRDALNEIFDKEDIDSCIHFAGLKAVGESVAKPWEYYENNIAGTLTLVDVMRKHNVKNIIFSSSATVYGDPAIIPITEECPKGQCTNPYGWTKSMLEQILTDIQKADPEWNVVLLRYFNPIGAHKSGTIGENPNGIPNNLMPYITQVAVGKLKELGVFGNDYDTPDGTGVRDYIHVVDLAKGHVKALKKIEDNSGLSIYNLGTGKGYSVLDIVKNFEAATGVKIPYVIKPRRPGDIATCYSDASKAERELGWKAENGIKEMCADSWRWQSNNPNGYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F9D3</accession>
    <name>A0A174F9D3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper export regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cueR_1</name>
        <name evidence="3" type="ORF">ERS852478_02912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580142.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46833">
        <property type="protein sequence ID" value="CUO46833"/>
        <property type="gene ID" value="ERS852478_02912"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO46833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="203" mass="23966" checksum="50026756344C9558" modified="2016-09-07" version="1">MKIKDVEKRTGITSYNIRFYEKENLLIPKRNPVNGYREYTEEDILLLNRIKMLRMLDIPVSDIRKILYEKEALTSVLNTHLLKIKEEENRLRQNYFLCEELIKMDMSVTDLSEEMLDKMISGKEEYIYQLERIKRQDRIQKIFDISKLIVCIVGGVIAVIMCVQLYLELCNTYMSAPFKVITFVLGLILVVSILRIIVCNETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FDN4</accession>
    <name>A0A174FDN4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="3 7">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dpnM</name>
        <name evidence="10" type="ORF">BWLFYP14_03416</name>
        <name evidence="8" type="ORF">ERS852478_02896</name>
        <name evidence="9" type="ORF">GT712_18010</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="3 7"/>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000055">
        <property type="protein sequence ID" value="MZS90891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705143.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46450">
        <property type="protein sequence ID" value="CUO46450"/>
        <property type="gene ID" value="ERS852478_02896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1020.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012186">
        <property type="entry name" value="Ade-mod_methylase_MStsI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023095">
        <property type="entry name" value="Ade_MeTrfase_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012327">
        <property type="entry name" value="MeTrfase_D12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481">
        <property type="entry name" value="PTHR30481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02086">
        <property type="entry name" value="MethyltransfD12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036638">
        <property type="entry name" value="M_m6A_StsI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00505">
        <property type="entry name" value="D12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00571">
        <property type="entry name" value="dam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO46450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS90891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX67139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="645" mass="74378" checksum="C373AC68820FF3F9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FE73</accession>
    <name>A0A174FE73_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integrase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Prophage phiRv2 integrase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Int-Tn_5</name>
        <name evidence="10" type="ORF">BWLFYP14_03408</name>
        <name evidence="8" type="ORF">ERS852478_02904</name>
        <name evidence="9" type="ORF">GT712_17970</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000055">
        <property type="protein sequence ID" value="MZS90883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705153.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46630">
        <property type="protein sequence ID" value="CUO46630"/>
        <property type="gene ID" value="ERS852478_02904"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028259">
        <property type="entry name" value="AP2-like_int_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14657">
        <property type="entry name" value="Arm-DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="7">
        <location>
            <begin position="56"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="160"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO46630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS90883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX67131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="350" mass="41558" checksum="345DD32DC6D3AB32" modified="2016-09-07" version="1">MSAYKDKTQGTWYVSFRYIDWTGKKTQKLKRGFKTKKEALNYEKEFIRKTAADMKMEMNSFIQVYFEDKKNELKENSIRNKQHMMNKHIVPYFGTRKMNEITPAEIIQWQNAIQEKGYSKTYERMIQNQLNALFNHAQKIYNLKENPCKKVKKMGKSDANKLEFWTKAEYDRFIAGIEPGSEDYLIFEILFWTGIREGELLALSLSDFDMSGNLLHINKTYNRIKKRDVIDTPKTENSVRTIDIPNFLKEEVQEYAKKHYGFPEDQRLFPIVARTLQKRLKKYEALTGVKPIRVHDIRHSHVAYLIYQGVEPLIIKERLGHKDIQMTLNTYGHLYPSQQKKVAEMLDNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FG40</accession>
    <name>A0A174FG40_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO49232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201051.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49232">
        <property type="protein sequence ID" value="CUO49232"/>
        <property type="gene ID" value="ERS852478_02986"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033V7A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO49232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="129" mass="15355" checksum="A8625EAA1D14E04D" modified="2016-09-07" version="1">MSKRTERMSRSAAERINRKDIVIRQNNAELEELRSQYENLDICEEDKQVIDDYIACKDARADRMAEKLYEKGRKDVKKCIRIRKLIRRCMILSAIVTVVLIQYNKNEKLRESLEELLKMFRDGVSDENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FHV5</accession>
    <name>A0A174FHV5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201031.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48416">
        <property type="protein sequence ID" value="CUO48416"/>
        <property type="gene ID" value="ERS852478_02962"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010380">
        <property type="entry name" value="DUF975"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40076">
        <property type="entry name" value="PTHR40076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06161">
        <property type="entry name" value="DUF975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO48416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="360" mass="41315" checksum="3642CFE4753D76F0" modified="2016-09-07" version="1">MTSRRELKNYAKQAMSGKYGILILAFVAVQALALISSMISSALFPGEETIDIVLSYAFTFILTLLINVVAAGMNYMYLNIARGKVYSLNDLFYFYRHHPDRVIVAGFFMAVLNLLTMLPYTIYSNANLPGEDASVEVLITWLYTGVVLMIVGMIVYQILVIPLEMTYYILADKPELKSTEAMKESLEMMHGNFGRYLMLKISFIPLMFLSVFTFYIALLWIFPYMAMTEVMFYRDLTGELKVQKEEEERVARDYVNPMFDSYSQNEQPQEDQTHPQQFWSVTGDSSVASDENKEVQNNAASENTQDSLYGSVENNRTTQDNPYDSSESKEVQDSLQSQTIPEEEEDNEPKPWDEYFNSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FP38</accession>
    <name>A0A174FP38_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-ribose-binding periplasmic protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rbsB_4</name>
        <name evidence="6" type="synonym">rbsB_3</name>
        <name evidence="6" type="ORF">BWLFYP14_03544</name>
        <name evidence="3" type="ORF">ERS852478_03029</name>
        <name evidence="5" type="ORF">GT712_01525</name>
        <name evidence="4" type="ORF">GT728_10210</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">BIOML-A1</strain>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000021">
        <property type="protein sequence ID" value="MZL33562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704974.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50638">
        <property type="protein sequence ID" value="CUO50638"/>
        <property type="gene ID" value="ERS852478_03029"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033253447" evidence="1">
        <location>
            <begin position="25"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="72"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO50638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS87804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX67269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="369" mass="40301" checksum="03F29D156F9D0C0F" modified="2016-09-07" version="1">MKRAAAAAISLMTGLAMLTGCSRAEVEETIQPLVADAIEESDSEAEAVKEEDESPLIPEIDTDIKIHAGSRIAVVSKCVKGEYWKMVKKGMEDAVKEINKAYGYKKDDQITMTFEGPDNEEDVETQINTIDAVIAENPDVLCISASDMDSCEAQLEAAKENGIPVIAFDSNVAEKKLVKAYRGTDNVQVGKMAAYQLGSALGKMGKVAVFSAQQKTKSVQDRVEGFMNNIGKYGDIEVVETIYSDQVDDMEASMKEVLEKYPTLDGVFCTNADITEMYLNLEKSDEHDAPALVGVDATTKQQEAIRNGEEIGCVSQQPYAMGYQTIWAAVETTAPKKSVVIEKNVLSNPAWIDADCLDDPDYSGYLYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FQ28</accession>
    <name>A0A174FQ28_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379934.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51821">
        <property type="protein sequence ID" value="CUO51821"/>
        <property type="gene ID" value="ERS852478_03057"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO51821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="562" mass="64183" checksum="4994C9C619262593" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FUA3</accession>
    <name>A0A174FUA3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO52386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201115.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52386">
        <property type="protein sequence ID" value="CUO52386"/>
        <property type="gene ID" value="ERS852478_03079"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO52386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="180" mass="21391" checksum="DA6972597ECC508A" modified="2016-09-07" version="1">MQLYQFEKIYSQMEREFGKIRKGEEETYAMLLLPMEGNVLKIHREFPGANSRRLREAIALALFDVKVNYSGEEYDTGKFRNRENEMLERALLMAFDPYTNHEIMELLKEQFHVDMLSQEQVKEYYKFPVMCLLRIKESIDTWEKRSGSDGYFDFIEGYMGREITGTEMNFSIMSSGIFDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FYI1</accession>
    <name>A0A174FYI1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Energy-coupling factor transporter ATP-binding protein EcfA1</fullName>
            <ecNumber evidence="8">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ecfA1</name>
        <name evidence="8" type="ORF">ERS852478_03168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705983.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55294">
        <property type="protein sequence ID" value="CUO55294"/>
        <property type="gene ID" value="ERS852478_03168"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030947">
        <property type="entry name" value="EcfA_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04520">
        <property type="entry name" value="ECF_ATPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="14"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO55294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="281" mass="31190" checksum="8A5689327222411A" modified="2016-09-07" version="1">MGIIKAFKLGFDYLKYDEDGNVQDTQRAVNDVNLDIEAGQFVAVLGHNGSGKSTLAKHLNALLLPTEGTLWVDGIDTSKEPELWKVRQKAGMVFQNPDNQIIGTVVEEDVGFGPENMGVPTEKIWERVDESLKKTGMTSYRYHSPNKLSGGQKQRVAIAGVMAMRPKCIILDEPTAMLDPNGRKEVLEAVSDLNRREGVTVILITHYMEEVVHADKVYVMDNGEVVMQGTPREIFSQVETLKEYRLDVPQVTLLAHELHKAGVDVSEGILTTEELVNALCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G1C5</accession>
    <name>A0A174G1C5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spermidine/putrescine-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">potD_2</name>
        <name evidence="7" type="ORF">ERS852478_03189</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201226.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56274">
        <property type="protein sequence ID" value="CUO56274"/>
        <property type="gene ID" value="ERS852478_03189"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0687">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="62"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO56274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="614" mass="69249" checksum="C5C7F41B9C6D94F7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G3R1</accession>
    <name>A0A174G3R1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Trifunctional nucleotide phosphoesterase protein YfkN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yfkN</name>
        <name evidence="6" type="ORF">ERS852478_03213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57182">
        <property type="protein sequence ID" value="CUO57182"/>
        <property type="gene ID" value="ERS852478_03213"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="647"/>
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            <begin position="39"/>
            <end position="275"/>
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    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="5">
        <location>
            <begin position="371"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO57182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="647" mass="71732" checksum="070FD8648D9BD0C5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GC86</accession>
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    <reference evidence="2 4" key="1">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 4">2789STDY5834863</strain>
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    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CUO58676">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="22"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF12654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58676.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VUX67206.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="206" mass="23961" checksum="EAB34886022FA912" modified="2016-09-07" version="1">MDNYEKQVYTGRELFLKYNQDKLIEKYGLKHDEEYLYLKYIETEYRINRRNGAIEYATGEEWTDCREYTVVMTIYDFLCCSGQEILPPLTGQWQPVGRFVTAGSSPSTDPFVEKYARAFSGKVEEVKQACICLGGKQTKRLAGADLTFEMPVLPEFSVLFQFWDGDEEFPPKILLLWDKVSLSYLHFETTYYLQGDLLKAILQIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GCL2</accession>
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        <submittedName>
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        </submittedName>
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            <strain evidence="8 9">2789STDY5834863</strain>
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    </reference>
    <comment type="subcellular location">
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="398"/>
        </location>
    </feature>
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        <source>
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        </source>
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        <source>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO58878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="437" mass="46343" checksum="4EED255721A802C2" modified="2016-09-07" version="1">MKKGKGIALLPIVVFLVLYLGLGILFEYVMEIPMGFYNVPIVVAFLAAILVACLQNRALDFDKKLEIMAQGVGDKNIITMLLIFLAAGSFVGVVGRSSAESVAYCMLSLIPARFSVSVLFIVACFVSVAMGTSVGTITLLTPIAAAVSTASGFDLAFCVASVMGGAMFGDNLSFISDTTIAACNGQGCEMKDKFRENFWIALPAAVATLILILILSFQTEIQGRVIQPYHLTQVIPYVLVLIGGIVGINVFVVLLTGIVSGAFIMLIGGHTTPVEILKNMGSGVSGMFETCMVAILVAAMCALIREYGGFDALLSWIHKIFRGKKGGQLGMGLLVGTMDIATANNTVAIVMANPIAKEMAEEYGITPRKTASILDTFSCVFQGVIPYGAQMLVAISAVNELGGEISAFQIMPKLFYPMLLLLSSLITIMRGSDRTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GIQ4</accession>
    <name>A0A174GIQ4_9FIRM</name>
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        <submittedName>
            <fullName evidence="2">Transposase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03335</name>
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    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000031">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_055201282.1">
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    <dbReference type="EnsemblBacteria" id="CUO61048">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO61048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
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    <sequence length="147" mass="17378" checksum="4C285BC8A44EC05A" modified="2016-09-07" version="1">MGKDIFNIDKNKLSYGRGYVYSLQYHLVWCTKYRKKVLKNGIDTECEEMLQNLAEEYKFQILAMEVMPDHIHLLVDCKPQFYISDMIKIMKGNLARQMFLAYPELKKELWGGHLWNPSYCAITVSDRSRDQVLAYIEGQKEKEKKKA</sequence>
</entry>
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    <accession>A0A174GRY4</accession>
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        <submittedName>
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        <submittedName>
            <fullName evidence="12">Putative amino-acid permease protein YxeN</fullName>
        </submittedName>
    </protein>
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        <name evidence="12" type="ORF">BWLFYP14_02333</name>
        <name evidence="8" type="ORF">ERS852478_03464</name>
        <name evidence="9" type="ORF">ERS852523_00011</name>
        <name evidence="11" type="ORF">GT712_16610</name>
        <name evidence="10" type="ORF">GT728_16135</name>
    </gene>
    <organism evidence="8 13">
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        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO94594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708210.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000161_gene1325"/>
    <dbReference type="EnsemblBacteria" id="CUO65233">
        <property type="protein sequence ID" value="CUO65233"/>
        <property type="gene ID" value="ERS852478_03464"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94594">
        <property type="protein sequence ID" value="CUO94594"/>
        <property type="gene ID" value="ERS852523_00011"/>
    </dbReference>
    <dbReference type="GeneID" id="66493943"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="17"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO65233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO94594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL34680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS90636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX65963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="219" mass="24375" checksum="2D1EE9CCCA2715E7" modified="2016-09-07" version="1">MDFEFIREQTPLYIEAAKLTLHMAVIGVLLAIVVGLVCSMIKYFRIPVLRQIVECYIELSRNTPLLIQLFFLYFGLPKIGIVLSSEQCAITGLTFLGGSYMAEAFRSGLDNVPPIQVESALSLGMSKSQVFTNIILPQAVSNSIPAFCANAIFLIKETSVFSAVALADLMFVTKDLIGIYYKTDEALFMLVIAYLIILLPISLICSFVERRVRYAEYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GTU4</accession>
    <name>A0A174GTU4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-acetyl-ADP-ribose deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ymdB_2</name>
        <name evidence="2" type="ORF">ERS852478_03422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO63925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070102141.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63925">
        <property type="protein sequence ID" value="CUO63925"/>
        <property type="gene ID" value="ERS852478_03422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045425">
        <property type="entry name" value="DUF6508"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20118">
        <property type="entry name" value="DUF6508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO63925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="300" mass="33772" checksum="DD637F20CCF54CCF" modified="2016-09-07" version="1">MERIHIVKKSVTKLDVDCVVNAANEGLWAGGGVCGAIFKEAGYNELTDACTKIGHCDTGNAVITPGFQLKAKYIIHAVGPQWHGGSHNKEHLLRKCYQTALLLARDNGCKSIGFPLISSGIYGYPKKEAWQVVLRAVADSLDSFVDMEVYFAVLDDTMLAMGQEIYHAMFDYTGDSLLVSIDKEKLWQCIELLCKIRKIEWKTPPSKNGLNYFPFPIYPEGIWQVFNLMKPDRDYGKHMEQQPRNIVPSEMSVEQINTRLTLIQRSERFGDGNVAAEIENGNLLKMLLRLDDLLNKSVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GUW1</accession>
    <name>A0A174GUW1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS66 family</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Transposase IS66 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02284</name>
        <name evidence="3" type="ORF">ERS852478_03450</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64609">
        <property type="protein sequence ID" value="CUO64609"/>
        <property type="gene ID" value="ERS852478_03450"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039552">
        <property type="entry name" value="IS66_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13817">
        <property type="entry name" value="DDE_Tnp_IS66_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="1">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_IS66_C" evidence="2">
        <location>
            <begin position="85"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO64609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="142" mass="16358" checksum="FC5103F5CCE6B60E" modified="2016-09-07" version="1">MVEDFFAWVKEQLSQCTVPPKSKTGQGLQYLVNQELYLKVFLTDGDVPIDNSASERSIRTFCIGKKNWMFHNTANGASANAMVYSISETAKLNSLRPYYYFRHILTELPKRCDVNGKINPAELDDLMPWSEELPDECRKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GWW0</accession>
    <name>A0A174GWW0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Arginine transport ATP-binding protein ArtM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">artM_2</name>
        <name evidence="9" type="ORF">BWLFYP14_02335</name>
        <name evidence="6" type="ORF">ERS852478_03466</name>
        <name evidence="8" type="ORF">GT712_16600</name>
        <name evidence="7" type="ORF">GT728_16125</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">BIOML-A1</strain>
            <strain evidence="8 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708208.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65280">
        <property type="protein sequence ID" value="CUO65280"/>
        <property type="gene ID" value="ERS852478_03466"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO65280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL34678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS90634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX65965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="251" mass="28668" checksum="2C43AA18B7A8A101" modified="2016-09-07" version="1">MGQPILEVEHLKKSYVNNVPILDDVSFSLQKGEVVVIVGPSGCGKSTFLRCINRLEEIDTGVLKLNGVSYEKEKKNISKVREKIGMVFQSYDLFPNMTILNNLLLAPMKVQKRNKEEVKKEAEQLLDRVGLLDKKDNYPRQLSGGQKQRVAIVRAMLMHPEIMLLDEITAALDPEMVREVLQVVLELAKTGMTMLIVTHEMEFARSVADRVIFMDKGNIVEENTPEQFFDNPETDRAKQFLNSFHYETVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H1I2</accession>
    <name>A0A174H1I2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO68882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201449.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000102.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68882">
        <property type="protein sequence ID" value="CUO68882"/>
        <property type="gene ID" value="ERS852478_03581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO68882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="64" mass="7124" checksum="91F9D69779434F65" modified="2016-09-07" version="1">MNEQKQYVCPWCGGKDVVEGIQSTYAKVQPNKALTLKGENLIHVICKNCGTAVRSYVENPQVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HB09</accession>
    <name>A0A174HB09_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional repressor DicA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO70055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015530715.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70055">
        <property type="protein sequence ID" value="CUO70055"/>
        <property type="gene ID" value="ERS852478_03624"/>
    </dbReference>
    <dbReference type="GeneID" id="15232332"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO70055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="209" mass="23925" checksum="9E90796F2B561FD0" modified="2016-09-07" version="1">MKDKELRKLIGSRVKQRRLELNLTQPYVAEKMGVTASTILRYENGSIDNTKKMVLEGLSEALHVSVEWLKGETDEYETDITDKRELQIRDAMGDILEQLPLALTKEEDAFSKDLLLLMLKQYGLFLDSFQFACKNFKGNAGQTDIAKTIGFESNEEYNEIMFLREITPTINALNEMADVVRLYSKKPKTAEQRLANLLSEVLYEDSESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HB21</accession>
    <name>A0A174HB21_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yehT_2</name>
        <name evidence="8" type="ORF">ERS852478_03637</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70536">
        <property type="protein sequence ID" value="CUO70536"/>
        <property type="gene ID" value="ERS852478_03637"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="43"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="171"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO70536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="279" mass="31754" checksum="5ABF74FD50FB8700" modified="2016-09-07" version="1">MDSVIFLSWTIALSCESSSDTGFSLPDTIHTFIHRKVLIKIMNIAICDDEILFTRELSSLLTHWAEKNDFSLTLYPYSNGDDLLTALRTIPVDLIFLDIIMPLLNGIDTAREIRSMRLTVPVIFLTSSREFALDSYDVKAFHYLLKPVNTLKLFSVMDDFFKTYHVPAETFVAHTADGFCSITLNDVDYLEAQNKQVLVCLSNGTTLKIRELFVKCEGVFTPEKGFFKCHRSYIVNLSHIKQFTRTMVTTGISSVPISRNNYSAFKDAYFSYMFDSNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HCK8</accession>
    <name>A0A174HCK8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VanZ like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000044">
        <property type="protein sequence ID" value="CUO72652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72652">
        <property type="protein sequence ID" value="CUO72652"/>
        <property type="gene ID" value="ERS852478_03713"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="71"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO72652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="204" mass="23514" checksum="93BFB44E992F8D5A" modified="2016-09-07" version="1">MMKETIDLLGKILTNILTALYEPFGFSLLLSFLAMFFYLYAYKPIEAGKGWKNAMVTWYREFKESIFFRKLFFLAFVTSLILFRTLLNRNLWMNPLSNIMGGWGIWEIVNGEQQLTTECIENVIMMVPFSAVVMWTFHGKAGNGWNNILWLSGKIAFGFSLMIEMLQLLLRLGTFQLSDIFYNTVGGVLGGMCYWGIIKIKKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HIQ7</accession>
    <name>A0A174HIQ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional repressor AseR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aseR</name>
        <name evidence="2" type="ORF">ERS852478_03785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000049">
        <property type="protein sequence ID" value="CUO74783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201525.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74783">
        <property type="protein sequence ID" value="CUO74783"/>
        <property type="gene ID" value="ERS852478_03785"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO74783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="89" mass="10164" checksum="FC8730CF6F7803C5" modified="2016-09-07" version="1">METRDMILICKALSDTNRLEIVQMLSDGEKCGCKILDKFDITQPTLSHHMKILVDCGLVNDCKEGKWHHYSLNKKVIREASSFIEALGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HJ00</accession>
    <name>A0A174HJ00_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF3427 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Type I restriction enzyme EcoKI subunit R</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_03789</name>
        <name evidence="6" type="ORF">GT728_20435</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000049">
        <property type="protein sequence ID" value="CUO74873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000102">
        <property type="protein sequence ID" value="MZL35469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704886.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000102.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74873">
        <property type="protein sequence ID" value="CUO74873"/>
        <property type="gene ID" value="ERS852478_03789"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021835">
        <property type="entry name" value="DUF3427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11907">
        <property type="entry name" value="DUF3427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="342"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="556"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO74873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL35469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="1053" mass="121524" checksum="D44D4E68371B7DF1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HMI2</accession>
    <name>A0A174HMI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannosylfructose-phosphate synthase</fullName>
            <ecNumber evidence="3">2.4.1.246</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mfpsA_2</name>
        <name evidence="3" type="ORF">ERS852478_03769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.246" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000048">
        <property type="protein sequence ID" value="CUO74300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704447.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74300">
        <property type="protein sequence ID" value="CUO74300"/>
        <property type="gene ID" value="ERS852478_03769"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103011">
        <property type="term" value="F:mannosylfructose-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="197"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO74300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="377" mass="43373" checksum="036B0AB4C31B2CF1" modified="2016-09-07" version="1">MKQQINGNNPIRVLHMAPIRMGGITELVLTLSEKIDFEKVQFDYLTFEDTFDQASKRAKEAHSTIYRVDLQTVKNPIVRGLKKFFGIIKLVHSEQIKIIHINSSTPYEVLVAFAAKIGGAKKIIYHSHNSSYYPGQKLVKLSEVFKWFMPFVITDYLACSDAAARFMFPKKIVDAENYTVIKNGVDYDKHSFKPEVRTELRKKYGLENNFVLGHVGRFNVQKNHEFLIDIFYEVYKHDNSARLFLVGIGETENQIKEKVKRLGIEEVVIFHGLSDEVNRLWNMLDVFVMPSLYEGLPVAGVEAQANGLPLIVSNTITQELKITDAVEYIGLDEKTSKWCEVIERYNGYKRKNTRMEITNAGFNIDDTAIRLERIYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HMU8</accession>
    <name>A0A174HMU8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative UDP-N-acetyl-D-mannosaminuronic acid transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000048">
        <property type="protein sequence ID" value="CUO74205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74205">
        <property type="protein sequence ID" value="CUO74205"/>
        <property type="gene ID" value="ERS852478_03765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO74205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="71" mass="8478" checksum="3B42FE70A2A3919F" modified="2016-09-07" version="1">MAAHQGKIDGLMLGVGAGFDYYAENIKRAPMWMQKHNLEWVYRLVQDPKRLFKRYWSTNTKFIWNAMIRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HSQ2</accession>
    <name>A0A174HSQ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000053">
        <property type="protein sequence ID" value="CUO75939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75939">
        <property type="protein sequence ID" value="CUO75939"/>
        <property type="gene ID" value="ERS852478_03819"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO75939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="102" mass="12224" checksum="D51C79CBC448678E" modified="2016-09-07" version="1">MKPSDFQKTVQCRFESCLKKVVRHVVKDYQQKLKRRQEKETLFCELPEIVVENLAVWDDYETDYTIFNVCGYDIRVYDDELAEALRKLQSAQPQRSTEKSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JFN9</accession>
    <name>A0A174JFN9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_00388</name>
        <name evidence="1" type="ORF">ERS852478_01968</name>
        <name evidence="2" type="ORF">ERS852523_00122</name>
        <name evidence="4" type="ORF">GT712_18310</name>
        <name evidence="3" type="ORF">GT728_09090</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO14700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO97441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000059">
        <property type="protein sequence ID" value="MZS90946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707498.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2280"/>
    <dbReference type="EnsemblBacteria" id="CUO14700">
        <property type="protein sequence ID" value="CUO14700"/>
        <property type="gene ID" value="ERS852478_01968"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97441">
        <property type="protein sequence ID" value="CUO97441"/>
        <property type="gene ID" value="ERS852523_00122"/>
    </dbReference>
    <dbReference type="GeneID" id="66495586"/>
    <dbReference type="eggNOG" id="COG0822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO14700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO97441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX62258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="230" mass="24779" checksum="827FC70F43D1B173" modified="2016-09-07" version="1">MIYSREVEEMCPVAQGVHHGAAPIPEEAKWVQAKEVKDISGLTHGVGWCAPQQGACKLTLNVKEGIIQEALVETIGCSGMTHSAAMASEILPGLTVMEALNTDLVCDAINTAMRELFLQIVYGRTQSAFSEEGLPVGAGLEDLGKGLRSQVGTMYGTLKKGPRYLEMAEGYVTGIALDADDEIIGYQFVSLGKMTDFIKKGDDPNTAWEKAKGQYGRVADAVKIIDPRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K393</accession>
    <name>A0A174K393_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell wall hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Spore cortex-lytic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sleB</name>
        <name evidence="6" type="ORF">BWLFYP14_02675</name>
        <name evidence="3" type="ORF">ERS852478_00178</name>
        <name evidence="4" type="ORF">ERS852523_00335</name>
        <name evidence="5" type="ORF">GT728_06100</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
            <strain evidence="4 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000003">
        <property type="protein sequence ID" value="CUP03905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993931.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000032_gene380"/>
    <dbReference type="EnsemblBacteria" id="CUN45711">
        <property type="protein sequence ID" value="CUN45711"/>
        <property type="gene ID" value="ERS852478_00178"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03905">
        <property type="protein sequence ID" value="CUP03905"/>
        <property type="gene ID" value="ERS852523_00335"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011105">
        <property type="entry name" value="Cell_wall_hydrolase_SleB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042047">
        <property type="entry name" value="SleB_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07486">
        <property type="entry name" value="Hydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014251798" evidence="1">
        <location>
            <begin position="33"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_2" evidence="2">
        <location>
            <begin position="160"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN45711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP03905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL32789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="278" mass="30507" checksum="1532FC7E1BFD78FF" modified="2016-09-07" version="1">MKVQKKESKQSGNPARSLILVTVCTCTAIAFAAGGRIADFNGKNKVYAASENREKTFSSDADETDVLPTGIAGVVSGMNDTASPKKSVTRIGTSCEQVMVGQRIKVIEDNMAEFDVSSSMESSINELDARTAALAESARMMSDEDYDTLLHIVEAEAGTEDVKGRILVANVIMNRIKNKEFPDTVTEVVWQNTNGVPQFSPTYDGRINEVTVTDETREAVRQALEGVDYSEGALFFIQKSEAESQNVSWFEKDLKRLFKYGVHEFYTYPDSAESSTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KMC1</accession>
    <name>A0A174KMC1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Lipopolysaccharide export system ATP-binding protein LptB</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lptB_1</name>
        <name evidence="5" type="synonym">lptB</name>
        <name evidence="5" type="ORF">ERS852478_00693</name>
        <name evidence="6" type="ORF">ERS852523_00651</name>
        <name evidence="7" type="ORF">GT728_03700</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">2789STDY5834863</strain>
            <strain evidence="6 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP13122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578122.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000015_gene3707"/>
    <dbReference type="EnsemblBacteria" id="CUN64807">
        <property type="protein sequence ID" value="CUN64807"/>
        <property type="gene ID" value="ERS852478_00693"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13122">
        <property type="protein sequence ID" value="CUP13122"/>
        <property type="gene ID" value="ERS852523_00651"/>
    </dbReference>
    <dbReference type="GeneID" id="66493470"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN64807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP13122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL32320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="252" mass="28142" checksum="D6BF36D2F55C83EE" modified="2016-09-07" version="1">MALLEVNHLNISFGGLHAVDDFHVSIEKGQLYGLIGPNGAGKTTIFNLLTGVYKPDEGIINLDGQDITGKSTIDINKAGIARTFQNIRLFHQMSVLDNVKAGLHNHDKYSLFTSIVHTPKYFKVEKTMNEEAMKLLKVFDLDKEADILASNLPYGKQRKLEIARALATKPKLLLLDEPAAGMNPNETEELMDTIRFVRDNFDMTILLIEHDMKLVSGICEELTVLNFGHVLRQGKTSDVLHDPEVIKAYLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LAE7</accession>
    <name>A0A174LAE7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3 6">HTH-type transcriptional regulator ImmR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">immR_1</name>
        <name evidence="2" type="synonym">immR_2</name>
        <name evidence="6" type="synonym">immR_3</name>
        <name evidence="6" type="ORF">BWLFYP14_01655</name>
        <name evidence="2" type="ORF">ERS852478_01315</name>
        <name evidence="3" type="ORF">ERS852523_00907</name>
        <name evidence="5" type="ORF">GT712_09480</name>
        <name evidence="4" type="ORF">GT728_08155</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000007">
        <property type="protein sequence ID" value="CUP21133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000015">
        <property type="protein sequence ID" value="MZL33172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993399.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000047_gene1258"/>
    <dbReference type="EnsemblBacteria" id="CUN88839">
        <property type="protein sequence ID" value="CUN88839"/>
        <property type="gene ID" value="ERS852478_01315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21133">
        <property type="protein sequence ID" value="CUP21133"/>
        <property type="gene ID" value="ERS852523_00907"/>
    </dbReference>
    <dbReference type="GeneID" id="66494927"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN88839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP21133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX64799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="71" mass="8470" checksum="04AB55DF42798CAF" modified="2016-09-07" version="1">MKFQRIQDLRTDADMSQKQLSEILHISQRSYSHYETGSRNIPVEMLIRLANYYDISVDYLVGRTDKKEMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NRM4</accession>
    <name>A0A174NRM4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Septum site-determining protein MinD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cell division inhibitor MinD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">minD_4</name>
        <name evidence="12" type="synonym">minD</name>
        <name evidence="10" type="synonym">minD_1</name>
        <name evidence="13" type="synonym">minD_3</name>
        <name evidence="13" type="ORF">BWLFYP14_02630</name>
        <name evidence="10" type="ORF">ERS852478_00132</name>
        <name evidence="11" type="ORF">ERS852523_01858</name>
        <name evidence="12" type="ORF">GT728_15935</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">2789STDY5834863</strain>
            <strain evidence="11 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 17">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParA family. MinD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP51293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000047">
        <property type="protein sequence ID" value="MZL34643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703173.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000020_gene93"/>
    <dbReference type="EnsemblBacteria" id="CUN44599">
        <property type="protein sequence ID" value="CUN44599"/>
        <property type="gene ID" value="ERS852478_00132"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP51293">
        <property type="protein sequence ID" value="CUP51293"/>
        <property type="gene ID" value="ERS852523_01858"/>
    </dbReference>
    <dbReference type="GeneID" id="66495892"/>
    <dbReference type="eggNOG" id="COG2894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010223">
        <property type="entry name" value="MinD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01968">
        <property type="entry name" value="minD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="9">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN44599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP51293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL34643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX66258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="262" mass="28587" checksum="86040BA3E803C3A1" modified="2016-09-07" version="1">MSEVIVITSGKGGVGKTTTVANIGTGLAMLGKKVVVVDTDIGLRNLDVVLGLENRIVYNLVDVINGSCRLRQALIKDKRHPELCLLPSAQTKDKSAVSPEQMIKLTDDLREQFDYILLDCPAGIEQGFKNAIAGADKALVVTTPEVSAIRDADRIIGLLEANEIRDISLIINRLRPDMIARGDMMSVDDVTDILAVDLIGTILDDEQIVIATNQGEPLSGKSSQAEEEYMNICKRLLGEEIPFADINRKQGLLRKIGSFFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NSQ6</accession>
    <name>A0A174NSQ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02616</name>
        <name evidence="1" type="ORF">ERS852478_00118</name>
        <name evidence="2" type="ORF">ERS852523_01872</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP51673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703150.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000151.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44237">
        <property type="protein sequence ID" value="CUN44237"/>
        <property type="gene ID" value="ERS852478_00118"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP51673">
        <property type="protein sequence ID" value="CUP51673"/>
        <property type="gene ID" value="ERS852523_01872"/>
    </dbReference>
    <dbReference type="GeneID" id="66495906"/>
    <dbReference type="eggNOG" id="ENOG5032W0W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN44237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP51673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="85" mass="9800" checksum="0B5DB666DD097445" modified="2016-09-07" version="1">MEELYRIIEQKIKDAGYPRAISGEMVYGDICDQIEGKENGSYVLLSKVEDDVIFEYHITVMDDEFNLGLLTIRTPEGVFETDFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174RLL5</accession>
    <name>A0A174RLL5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00832</name>
        <name evidence="3" type="ORF">ERS852523_03031</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000037">
        <property type="protein sequence ID" value="CUP85011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69645">
        <property type="protein sequence ID" value="CUN69645"/>
        <property type="gene ID" value="ERS852478_00832"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP85011">
        <property type="protein sequence ID" value="CUP85011"/>
        <property type="gene ID" value="ERS852523_03031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN69645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP85011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="46" mass="5076" checksum="046A4A66D3CC676A" modified="2016-09-07" version="1">MAAILMNYKIPGYYIFFICLAVISCFSNPGMVVLAGCRVDNIDQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SYE8</accession>
    <name>A0A174SYE8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TcpE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02154</name>
        <name evidence="3" type="ORF">ERS852523_03573</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000055">
        <property type="protein sequence ID" value="CUQ00150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005611098.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000055.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21244">
        <property type="protein sequence ID" value="CUO21244"/>
        <property type="gene ID" value="ERS852478_02154"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ00150">
        <property type="protein sequence ID" value="CUQ00150"/>
        <property type="gene ID" value="ERS852523_03573"/>
    </dbReference>
    <dbReference type="GeneID" id="64017258"/>
    <dbReference type="GeneID" id="66579002"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025608">
        <property type="entry name" value="TcpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12648">
        <property type="entry name" value="TcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO21244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ00150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="129" mass="14944" checksum="C577BC1A77396795" modified="2016-09-07" version="1">MKKIRSYTSIWNVEKVLYAINDVNLPFPVTFTQITWFVLTEFIIILFADVPPLSMIEGAFLKYFGIPVALTWFMSQKTFDGKKPYSYIKTMVLYALRPKVTYAGKAVNLHKQKFEETITAVRSVTYVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WZ63</accession>
    <name>A0A173WZ63_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative transposase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="15">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BWLFYP14_02644</name>
        <name evidence="15" type="ORF">ERS852478_00146</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the transposase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44919">
        <property type="protein sequence ID" value="CUN44919"/>
        <property type="gene ID" value="ERS852478_00146"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="14">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_IS605" evidence="12">
        <location>
            <begin position="171"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="13">
        <location>
            <begin position="309"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="215"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUN44919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VUX66272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="384" mass="44935" checksum="963C1701BB7B9ED2" modified="2016-09-07" version="1">MRKSFKTEINPSEEQKIKIRKTIGTCRFIYNFYLAHNKELYNNGEKFMSSNKFRVWLNNEYLPQHPEYSWIKEAYSKAVTQAVNNGQTAFTRFFNHESAFPNFKKKGRSDVKMYFVKNNPKDCRCERHRINIPSLGWVRIKEKGYIPTTKDGYVIKSGSVSIKADRFYVSVLVEIPDNKITDDPNEGIGIDLGLKEFAIVSNGKTYKNINRSARLKKLEKQLIRKQRSLSRKYENLKKGESTQRANLQKQKRKVQKLHHKIDNIRTDYINKTIAEIVKTKPSYITIEDLNVKGMMKNRHLSKAVASQKFYEFRTKLQAKCREKGIELRVVDRWYPSSKTCHCCGAVKKDLKLSDRIFKCSCGYVEDRDFNAALNLRDVTTYEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X0N2</accession>
    <name>A0A173X0N2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_00107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578438.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43908">
        <property type="protein sequence ID" value="CUN43908"/>
        <property type="gene ID" value="ERS852478_00107"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="9"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN43908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="233" mass="26036" checksum="AFCC5786512B2686" modified="2016-09-07" version="1">MLADKLNLVKKNIEEACDTAGRSPQEVTLIAVSKTKPVEMLKEAYDAGARVFGENKVQEIVDKYDQMPSDVQWHMIGHLQRNKVKYIIDKVSMIHSVDSVRLAEAIEKEAAKKDICMPVLIEVNVAGEESKFGLSVEEVLPFLEEISSYEHLQVKGLMTIAPFVANPEENREVFQKLKKLSVDIAAKNINNVNMSVLSMGMTNDYQVAVEEGATMVRVGTGIFGERDYSIKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X246</accession>
    <name>A0A173X246_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Beta-lactamase</fullName>
            <ecNumber evidence="3 6">3.5.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pbpA_1</name>
        <name evidence="9" type="ORF">ERS852478_00133</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a beta-lactam + H2O = a substituted beta-amino acid</text>
            <dbReference type="Rhea" id="RHEA:20401"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35627"/>
            <dbReference type="ChEBI" id="CHEBI:140347"/>
            <dbReference type="EC" id="3.5.2.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-D beta-lactamase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transpeptidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.6" evidence="3 6"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199503.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000070.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44625">
        <property type="protein sequence ID" value="CUN44625"/>
        <property type="gene ID" value="ERS852478_00133"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017001">
        <property type="term" value="P:antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002137">
        <property type="entry name" value="Beta-lactam_class-D_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00337">
        <property type="entry name" value="BETA_LACTAMASE_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_dimer" evidence="8">
        <location>
            <begin position="60"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="7">
        <location>
            <begin position="624"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="682"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="5">
        <location>
            <position position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602137-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN44625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="964" mass="107197" checksum="DC32A777C18C400C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X2R3</accession>
    <name>A0A173X2R3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">mutS</name>
        <name evidence="11" type="ORF">BWLFYP14_02641</name>
        <name evidence="10" type="ORF">ERS852478_00143</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44845">
        <property type="protein sequence ID" value="CUN44845"/>
        <property type="gene ID" value="ERS852478_00143"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="9">
        <location>
            <begin position="693"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="619"/>
            <end position="626"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN44845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX66269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="876" mass="99251" checksum="7C811F07341E9AFC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X8B4</accession>
    <name>A0A173X8B4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00219</name>
        <name evidence="2" type="ORF">GT728_05900</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199510.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46885">
        <property type="protein sequence ID" value="CUN46885"/>
        <property type="gene ID" value="ERS852478_00219"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN46885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL32751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="351" mass="40675" checksum="A1CB990D9776D669" modified="2016-09-07" version="1">MEIGGFFPYQPVDSEPNNYVEHTCPDPGDTAHLMSGRCAIYYCLRDLMLTDQKRVAYLPSYDCETVLGCFVKAGYEIHYYDFDKNLSPVFEEEMIPQISVLLVCGYYGYPTYDENFVKKCKASGVSVIVDTTHTAFSPLPACPDSDYIAVSLRKWMGVASGGLAIKRKGTFGVKPIPINKEQFSLRDQALQSRETYEHTGNEDYNKEGNDVFWKAEFMLREIFDIQEGDEASLKTILHYPFRDAIRKRQENYHYLLEHLPERSDIRPVFPYLSDDICPMFFPFFVENRDALIKHLADRHIPPKVYWPVPPFVKVEDYPGAQYIYSHIMSVSCDERFNTDDMQKIVEAFENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XHT8</accession>
    <name>A0A173XHT8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1,3-propanediol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.202</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dhaT</name>
        <name evidence="3" type="ORF">ERS852478_00331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.202" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059851.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51264">
        <property type="protein sequence ID" value="CUN51264"/>
        <property type="gene ID" value="ERS852478_00331"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047516">
        <property type="term" value="F:1,3-propanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="9"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN51264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="394" mass="41953" checksum="08F067F2F36C0AED" modified="2016-09-07" version="1">MNPFEFFIPQNITVGAGTLAKLPECAKKLGGSHAMLISGPTLRKMGVVDKAADYLKDAGMAVDIFTDVEANPSVTTVEKATEAYKDSGADFIVALGGGSPMDVAKAVGVTAKYGGSITEYEGAHKVPGKIVPLIAIPTTAGTGSEVTAFSVITDHSRDYKLTVFSYELLPAYAILDPELLTSAPASVAAACGIDAFIHAEEAYVSTAASPFSDAMAEKAMELIGGNIRRFVARRTDLEAAEAMLTGSLFAGIAFSFARLGNVHAMSHPVSAFFNVAHGVANAVLLPVIAEYNALADHGRYLKIYNYISPIPAYEDEFEPLMLVDAIRELNEDIGIPEDLTTAIRQAKKGEEISDEEIESKIDAMADDAMKSGNIAVNPRSSRKQDIVKLYYKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XKQ2</accession>
    <name>A0A173XKQ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Auxin efflux carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_00348</name>
        <name evidence="9" type="ORF">ERS852523_01540</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
            <strain evidence="9 11">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000013">
        <property type="protein sequence ID" value="CUP41513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055150784.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000008_gene2666"/>
    <dbReference type="EnsemblBacteria" id="CUN51850">
        <property type="protein sequence ID" value="CUN51850"/>
        <property type="gene ID" value="ERS852478_00348"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP41513">
        <property type="protein sequence ID" value="CUP41513"/>
        <property type="gene ID" value="ERS852523_01540"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN51850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP41513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="310" mass="34526" checksum="A3949406CBCA0CBF" modified="2016-09-07" version="1">MNISILLMEQIIQLFLMIFMGYLIVKVGLVKDEDSKVLSKIILYLIIPCVIINAFQVDYTMDTVKGLLLALAASVMTQVLLLIIISISGKLLHLNEVEIASVYYSNSGNLIVPIVTFILGQDWVLYGCVFMSVQLIFLWTHCKKIISRESSYDWKKIVLNINMISIFIGVVLFFAKIHLPEIINNTLGSVGSMIGPASMIVTGMLFAGMNLKQIFADKRVYFVSFLRLIAVPLLALVMIKISHLAMFSADGNKIILIVFLAIITPSASTITQMCQVYGNDSRYASAINVMTTLFSIITMPLMVMLFEAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XKY1</accession>
    <name>A0A173XKY1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381336.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52324">
        <property type="protein sequence ID" value="CUN52324"/>
        <property type="gene ID" value="ERS852478_00362"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN52324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="194" mass="21903" checksum="7B120A51E6E02EF8" modified="2016-09-07" version="1">MIITIARQCGSGGHEIGKELASRLGLELYDRKKLEEEAKKLGKLDENKEFFQEKAVNSLLYSIAVSYGESNPMEKSFELIRELTQQKSAVIIGRCSGAIYANDPEATTVFLHADKDCRIKRVMERDGINEKKAAKLIKEVDEKRASFHKFCTGKEWEDANQYQLSIDTGKLDISDAADMIINYINAKNIGQKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XN74</accession>
    <name>A0A173XN74_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Staphylococcal virulence regulator protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_3</name>
        <name evidence="2" type="ORF">ERS852478_00386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199593.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53013">
        <property type="protein sequence ID" value="CUN53013"/>
        <property type="gene ID" value="ERS852478_00386"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="455" mass="49536" checksum="897790D7066804E0" modified="2016-09-07" version="1">MAESNKMKDMPVNKLMIQMGIPMILSMALQAVYNIVDSAFVGNMRVGSEAALNALTLVFPVQMLMVAAGIGTGVGTNALLARTLGQGNREKAAKVAGNSLFLGVIIYVVCLLFGIFGVKAYISSQTVDAEVLEMGVSYLRICCVISFGIIFFSLFEKLLQATGRSLYSTIGQVVGAVVNIILDPIMIYGIGPCPEMGVKGAAYATVIGQVASAVLLLIFHMKLNREFGHGPKYMKPNAGVIKEIYAIGLPAIIAQALMSIMVYVMNLILKFNPSAQTAYGLFYKVQQFVLFLAFGLRDAITPIIAFAYGMRSKKRIQDAIKYGLIYTIALMILGIAITEIFPGAFAMLFNAGQSREYFIATMRVISVSFLFAGINVAYQGIYQALDGGLESLVISLLRQLIIILPLAGIFSLFVRNGQMGVSLIWWAFPITEIISCFVGYVFLKKIRKNRVDVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XNQ1</accession>
    <name>A0A173XNQ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53512">
        <property type="protein sequence ID" value="CUN53512"/>
        <property type="gene ID" value="ERS852478_00403"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041033">
        <property type="entry name" value="Prealbumin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17802">
        <property type="entry name" value="SpaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpaA" evidence="1">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="170" mass="18715" checksum="F33EA1D2B56D8DB6" modified="2016-09-07" version="1">MGQFWAKLNVGNAKLQKTSSNTSITDSNGNYSVAGATYGVFSDKDCTKQFATLTTDENGNTDVVEVKAGTVYIKELSAPAGYKVDKTVYSLKVEAGKTATLKVSDIPKVTDTLIELFKIDMETQKGNPQGNASLAGAEFTWKYYAGFYNKDKSPCRSYSYMGYKDNRRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XQC5</accession>
    <name>A0A173XQC5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199613.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54112">
        <property type="protein sequence ID" value="CUN54112"/>
        <property type="gene ID" value="ERS852478_00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN54112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="90" mass="10533" checksum="8BA8FBB7084D6FEF" modified="2016-09-07" version="1">MTQVFRVERNKNFTVMSNHHFKNKDLSLKAKGLLSLMLSLPEDWNYNIQGLASLSRDGIDSVRSAIKELEHYRYVERNIIRNESGYCTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XQK6</accession>
    <name>A0A173XQK6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">arlR_1</name>
        <name evidence="11" type="ORF">ERS852478_00416</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199608.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53853">
        <property type="protein sequence ID" value="CUN53853"/>
        <property type="gene ID" value="ERS852478_00416"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN53853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="223" mass="25462" checksum="A107FBF840EB90B8" modified="2016-09-07" version="1">MKILLIEDDRELAESMRFQLEKEGYETDICDDGEEGLYYMKERSHDLVILDRMLPSMDGITVLQEARKNHVSTPVIMLTALGELQDKLTGLKGGADDYMVKPFAFEELLARIQCMVRRPGRWEDTAVLSLGELIFDPESGRLEGNGKECTLSKREGALLELMLRNAGQTLPREVILNRVWGADSEVEDGNLDNYIHFLRRRLKSVRSTLNLKTVRGIGYRLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XQZ4</accession>
    <name>A0A173XQZ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized HTH-type transcriptional regulator yusO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yusO</name>
        <name evidence="2" type="ORF">ERS852478_00430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199618.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54311">
        <property type="protein sequence ID" value="CUN54311"/>
        <property type="gene ID" value="ERS852478_00430"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN54311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="157" mass="18644" checksum="41361EC963939D63" modified="2016-09-07" version="1">MWCPEDEKNEKEKREEKSMPALFMEINRQYGMRCMQRIREIGIQQGQMPIIMIVYRHNGCSQKEIAEWMGVTPPTVNVSIQRLEKADIVCRKRDDKDQRIMRVYLTENGRKIVEELQQESKAVEKVMFSNFSEAELCLLRRFFGQILDNISEIPVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XTB8</accession>
    <name>A0A173XTB8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Citrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54196">
        <property type="protein sequence ID" value="CUN54196"/>
        <property type="gene ID" value="ERS852478_00426"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031566">
        <property type="entry name" value="CitMHS_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16980">
        <property type="entry name" value="CitMHS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN54196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="521" mass="57338" checksum="E5ECAD5188DC943B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XU37</accession>
    <name>A0A173XU37_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54085">
        <property type="protein sequence ID" value="CUN54085"/>
        <property type="gene ID" value="ERS852478_00422"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN54085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="94" mass="10807" checksum="AB566C60F2BD37BC" modified="2016-09-07" version="1">MSKKKENAAVTVYTLQRTKLSQTDVDNFNAQYPKLDVKYTRAFHDRFLILDKMKAYHVGASLKDAGKKCFGINLIKDAGIVRDILQRLELETEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XZ59</accession>
    <name>A0A173XZ59_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="5">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroF_1</name>
        <name evidence="7" type="ORF">ERS852478_00495</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026076872.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPF010000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57291">
        <property type="protein sequence ID" value="CUN57291"/>
        <property type="gene ID" value="ERS852478_00495"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0722">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DHAP_synth_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PTHR21225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="6">
        <location>
            <begin position="37"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN57291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="343" mass="38781" checksum="BCA6961F4D3F9171" modified="2016-09-07" version="1">MSMKINHELPLPEVLKSQYPLSQELKKVKKQRDEEIRRIFTGESDKFVVLVGPCSADNEDTVCEYVHKLKTVADKVSDKLMIIPRVYTNKPRTTGDGYKGMLHQPDPDKAPDLLAGIIAIRKMHMRVMQETGLSSADEMLYPENRSYLDDILSYEAVGARSVENQQHRLTASGMDIPVGMKNPTSGDLSVMLNSVTAAQHPHHFIYRGNDVETSGNDLAHTILRGGVNQYGQTIPNYHYEDLMHLSALYAKKDLKNPAIIIDANHSNSNKQYKEQIRIVSEVLHSRNYNPELKKLVKGVMIESYLLEGRQDISDHMTPGCSITDPCLGWEDTERLIYDIAEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y690</accession>
    <name>A0A173Y690_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase PspE</fullName>
            <ecNumber evidence="2">2.8.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pspE_1</name>
        <name evidence="2" type="ORF">ERS852478_00523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.8.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025581338.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58238">
        <property type="protein sequence ID" value="CUN58238"/>
        <property type="gene ID" value="ERS852478_00523"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN58238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="103" mass="11465" checksum="454A8994ABA00E7C" modified="2016-09-07" version="1">MFPVETISAKMLDYYVGRRDTLIIDLREKESYMHSHVKGAVNMPYGEIDGYTAFPKGKILVLYCDRGGASLLLARQLAKLGYCTRSVIGGFGAYRGRNLVISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YDG2</accession>
    <name>A0A173YDG2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catabolite repression HPr</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">HPr family phosphocarrier protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">HPr-like protein Crh</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">crh_1</name>
        <name evidence="4" type="synonym">crh_2</name>
        <name evidence="4" type="ORF">BWLFYP14_03244</name>
        <name evidence="2" type="ORF">ERS852478_00612</name>
        <name evidence="3" type="ORF">GT712_08500</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000014">
        <property type="protein sequence ID" value="MZS89110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX66967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380118.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61025">
        <property type="protein sequence ID" value="CUN61025"/>
        <property type="gene ID" value="ERS852478_00612"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN61025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS89110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="87" mass="9182" checksum="2DEFCAF919D671CD" modified="2016-09-07" version="1">MVSKKVTVKNPTGLHLRPAGILCNEAMKYQSQITFVYDGGMANAKSVLSVLGACVKCGNEIELTCEGVDEQEALDHLVAAIDSGLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YFF5</accession>
    <name>A0A173YFF5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trehalose import ATP-binding protein SugC</fullName>
            <ecNumber evidence="7">3.6.3.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="6">sn-glycerol-3-phosphate import ATP-binding protein UgpC</fullName>
            <ecNumber evidence="6">3.6.3.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ugpC_1</name>
        <name evidence="7" type="synonym">sugC</name>
        <name evidence="7" type="ORF">BWLFYP14_03206</name>
        <name evidence="6" type="ORF">ERS852478_00650</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="7"/>
    <dbReference type="EC" id="3.6.3.20" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN62363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX66930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706080.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN62363">
        <property type="protein sequence ID" value="CUN62363"/>
        <property type="gene ID" value="ERS852478_00650"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN62363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="370" mass="41067" checksum="D01992A8CD485FE8" modified="2016-09-07" version="1">MASLSLQHINKTYPNGFQAVKDFNLEIEDKEFIIFVGPSGCGKSTTLRMIAGLEEISGGTLKIGDKVMNDVEPKDRDIAMVFQNYALYPHMTVYDNMAFGLKLRKVPKDQIDKAVREAARILDLEKLLDRKPKALSGGQRQRVAMGRAIVRNPKVFLMDEPLSNLDAKLRVQMRIEISKIHQRLGATIIYVTHDQTEAMTLGTRIVVMKDGVVQQVDTPQNLYQKPGNLFVAGFMGSPQMNFLDAVISEKGGNLIAKVGEHELVIPAAKAKALKDGGYVGKTVVLGIRPEDIHDSQMFIEASPSAPMTSVVKVYELLGAEVFLYFDVNGTQVTARVDPRTTAKTGDPIKFAFDMEKSHFFDKETELTICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YMN6</accession>
    <name>A0A173YMN6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lgt_1</name>
        <name evidence="2" type="synonym">lgt</name>
        <name evidence="4" type="ORF">ERS852478_00712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65382">
        <property type="protein sequence ID" value="CUN65382"/>
        <property type="gene ID" value="ERS852478_00712"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN65382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="376" mass="43117" checksum="160CAB68DC2E8656" modified="2016-09-07" version="1">MEMSIRFPGPGLVFDYVPRSFQIFGMEFTIYGVLIAVGALLGMGIVTLEAKRNGEDQNRYLDMMLISLLVSVAGSRLFYVAFSWGFYKENLNAILDFRNGGYALYGGLLFGFLAAAVFCRITKMSFWQSADIACPGILLGQAIGRWGNFFNRESFGEYTNLPWAMQIPVSAVRSGEVSGAMRDNLLTINGISYIQVQPVFLYESLWCLLLFLLLMAMRRKKKYEGELFMIYLAGYGLGRFFFEWLRTDKLYIPGTKVGISLVISAALFVIFMPTVIVRRVMVQKRAVIRRQRRKRFLDEAEKESRNKKDNLDMEAVMKTEEEARTEDGKQVESDEKQENMKKAEQNVNWENSEYTHIPEQWKQDVGNSPTNSKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YRS0</accession>
    <name>A0A173YRS0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine phosphatase stp</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Stp1/IreP family PP2C-type Ser/Thr phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">stp</name>
        <name evidence="2" type="ORF">ERS852478_00731</name>
        <name evidence="3" type="ORF">ERS852523_00612</name>
        <name evidence="5" type="ORF">GT712_03100</name>
        <name evidence="4" type="ORF">GT728_03825</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A1</strain>
            <strain evidence="5 8">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP12069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578159.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000016_gene3673"/>
    <dbReference type="EnsemblBacteria" id="CUN66037">
        <property type="protein sequence ID" value="CUN66037"/>
        <property type="gene ID" value="ERS852478_00731"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12069">
        <property type="protein sequence ID" value="CUP12069"/>
        <property type="gene ID" value="ERS852523_00612"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN66037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP12069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="248" mass="27393" checksum="F84C549334FCC4CA" modified="2016-09-07" version="1">MRIYSATDVGQKRKMNQDYVFATADPVGNLPNLFVVADGMGGHNAGDYASSHAVTSMVEEIRQDADFNPVKVIRHAIECVNTEILTQAQQDEKLRGMGTTIVAATIVGHYAYVANVGDSRLYVIGEKIQQITRDHSLVQEMVRMGELDPEQARKHPKKNIITRALGAEKTVDIDFFDLKLEPGDVVLMCSDGLSNMVEDSQLREIISDTSTDLDEKGRILIREANRNGGKDNIAIVLVEPFTDEVKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YVT7</accession>
    <name>A0A173YVT7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sugar fermentation stimulation protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">sfsA</name>
        <name evidence="5" type="ORF">BWLFYP14_01730</name>
        <name evidence="4" type="ORF">ERS852478_00791</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SfsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199801.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68291">
        <property type="protein sequence ID" value="CUN68291"/>
        <property type="gene ID" value="ERS852478_00791"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00095">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005224">
        <property type="entry name" value="SfsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040452">
        <property type="entry name" value="SfsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041465">
        <property type="entry name" value="SfsA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30545">
        <property type="entry name" value="PTHR30545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03749">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17746">
        <property type="entry name" value="SfsA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00230">
        <property type="entry name" value="sfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SfsA_N" evidence="3">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="SfsA" evidence="2">
        <location>
            <begin position="81"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN68291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="232" mass="26611" checksum="BC832BDCA2A4AA58" modified="2016-09-07" version="1">MKYEHITEGRFIDRPNRFIAHVEINGQVETVHVKNTGRCRELLVPGTQVFLEKSSNPARKTAYDLICVNKKGRGLINMDSQIPNKAALEWVKAGHLFPEKVQVTPEKTYGNSRFDLYVCSEKRKAFIEVKGVTLESDNIARFPDAPTERGVKHLKELIHCMQEGYEAYLLLVIQMKGVDRFEPNWETHREFGETLQEAKKAGVHILAYDCLVEPDRMEIQDPVPVCLASDWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z7K4</accession>
    <name>A0A173Z7K4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pilus assembly protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">TadE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01270</name>
        <name evidence="2" type="ORF">ERS852478_00888</name>
        <name evidence="4" type="ORF">GT712_08130</name>
        <name evidence="3" type="ORF">GT728_01175</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS89037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578565.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72224">
        <property type="protein sequence ID" value="CUN72224"/>
        <property type="gene ID" value="ERS852478_00888"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033HPU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012495">
        <property type="entry name" value="TadE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07811">
        <property type="entry name" value="TadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN72224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL31843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="153" mass="17046" checksum="A3F159A9701EF36D" modified="2016-09-07" version="1">MKDNFCITNEYSIIRKGSFTIETACVMPLILLVLMGLIYLSFFVHNRAWLTAAAYESAVSGSMEGIKKNGEIYDTARMRSEELGSIGFFGAENLGTQTNVGKEVQVTYDLDTISSYGNLSWHLRTEGKSAVINPVKHIRRLRAAQAVLREMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZAQ2</accession>
    <name>A0A173ZAQ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199836.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72268">
        <property type="protein sequence ID" value="CUN72268"/>
        <property type="gene ID" value="ERS852478_00890"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN72268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="279" mass="30908" checksum="C2F3EBD1BB6F2806" modified="2016-09-07" version="1">MLLQKEKQSIEEIGKKDKKIYERRKVSLSNIYDLLFPQKSRKYFRTNAKEHIGEVPSVKVSFCTSFRGKIKKGSLAVETALVLPLFFLGMVTLISFMDIYKLQTEHLTALCTKAKQAGMYAYLPGGDSVDDITLPDIYTYKPFGGLIPLPDVGVYNHVKVHAWTGTEFPDNEGEQGETEPMVYVTASGSVYHKNPGCSYLNVSLKQIPGSSAKSASNKYGEHYSACEICSRNQNPAGVVYVTEQGNRYHNLESCSGLKRSVRLVKASSVSEMGACSRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZBV2</accession>
    <name>A0A173ZBV2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Relaxase/Mobilisation nuclease domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72668">
        <property type="protein sequence ID" value="CUN72668"/>
        <property type="gene ID" value="ERS852478_00903"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005094">
        <property type="entry name" value="Endonuclease_MobA/VirD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03432">
        <property type="entry name" value="Relaxase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN72668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="479" mass="54741" checksum="1CB357649A85F5A7" modified="2016-09-07" version="1">MRANLRYEKNQKREDVKSHHYIISFDPRDGTDNGLTVDRAQELGEQFCKEHFPGHQALVCTHPDGHNHSGNIHVHIVINSLRIYEVPLLPYMDRPADTREGCKHRCTNAAMEYFKSEVMEMCHREGLYQIDLLNGSKERITEREYWAAKKGQLALDKENAVREAAGQPTKPTKFETDKAKLRRTIRQALSQAGSFDEFSSLLLREGVTVKESRGRLSYLTPDRTKPITARKLGDDFDKAAVLALLTQNAHRAAEQTKGIPEYPAAVKKPSQGEKTTKTTPADNTLQRMVDREAKRAEGKGVGYDRWAAKHNLKQMAATVTAYQQYGFSSPEELDEACSAAYAAMQESLTEQKQVEKTLNGKKELQRQVLAYSKTRPVRDGLKQQKNAKAKAAYRQKHESDFIIADAAARYFRENGISKLPSYKALQAEIETLIKEKNSGYNDYRAKREEYRRLQTVKGNIDQILRRSEPQRRKEQSHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZCK7</accession>
    <name>A0A173ZCK7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional ligase/repressor BirA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
            <ecNumber evidence="1">6.3.4.15</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Biotin--protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Biotin-[acetyl-CoA carboxylase] synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">birA_1</name>
        <name evidence="1" type="synonym">birA</name>
        <name evidence="3" type="ORF">ERS852478_00929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:11756"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199849.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73419">
        <property type="protein sequence ID" value="CUN73419"/>
        <property type="gene ID" value="ERS852478_00929"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00978">
        <property type="entry name" value="Bifunct_BirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030855">
        <property type="entry name" value="Bifunct_BirA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="2">
        <location>
            <begin position="65"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="1">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="1">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN73419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="322" mass="35410" checksum="1F59AE9C61E31E86" modified="2016-09-07" version="1">MTVKSSLLEMLEKNKGEVLSGESIAGELGCTRAAVWKAVKSLREEGYHIEAGPNKGYMLAKDTNRLSQEGIRLILDDPKVKIDIYDELESTNQTAKKEAMMGEAGHGAFVIARSQTAGRGRRGREFYSPADTGLYMSVILKPQGTIHDSLLITTAAAVAVYRAVAQLCGIQLDIKWVNDLFYKGKKVCGILTEAVTDFESGNIEFVVVGMGLNLYLDQENLPGELRNIAGALYETKEDAEQTDRNKLTATIVNELRKETADLKLSPDYVTHNMIPGHQITITDGNSSRQAFALEICRDGRLKVREEDGQETILSFGEVSVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZIY1</accession>
    <name>A0A173ZIY1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">(P)ppGpp synthetase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">GTP pyrophosphokinase ywaC</fullName>
            <ecNumber evidence="4">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ywaC_1</name>
        <name evidence="4" type="ORF">ERS852478_01020</name>
        <name evidence="5" type="ORF">GT712_17290</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000049">
        <property type="protein sequence ID" value="MZS90763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053319.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76362">
        <property type="protein sequence ID" value="CUN76362"/>
        <property type="gene ID" value="ERS852478_01020"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="3">
        <location>
            <begin position="45"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN76362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="207" mass="24770" checksum="FF6568390FD5D3FF" modified="2016-09-07" version="1">MTDEEYYEFIQPYEDAKQMLLTRLDVLNHNLYGDASARPIHNIQCRIKKKQSIEEKLQRKGKEPTVMNAKDYLQDIAGVRVICYFVDDIYNLTELLKSQSDLIVIRERDYIGNPKPNGYRSYHVIVGVPVYCLDGMEYFPVEIQFRTMSMDFWASMEHRISYKKERTDKEQLRDELREYANMLVEIESRFEQYNETDHQQEKRTVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZLY2</accession>
    <name>A0A173ZLY2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sensory transduction protein regX3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">regX3_2</name>
        <name evidence="7" type="synonym">regX3_3</name>
        <name evidence="7" type="ORF">BWLFYP14_01390</name>
        <name evidence="6" type="ORF">ERS852478_01015</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76228">
        <property type="protein sequence ID" value="CUN76228"/>
        <property type="gene ID" value="ERS852478_01015"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="39"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN76228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX64413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="143" mass="16688" checksum="D29F8BEBE828302D" modified="2016-09-07" version="1">MGKILLVSFEGAEEDLVNSVISVLDSGREKFLFQEIQFQSKIWHKGIAIDLKRREVVRDNRKIELTYTEFEILQLLAQNPGRVFSKEQIYDIVWKESYFGDYNIVMSHISHIREKIEDDPGNPVYIQTVWGVGYKFNEKAGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A162</accession>
    <name>A0A174A162_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yjcD</name>
        <name evidence="9" type="ORF">ERS852478_01149</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81893">
        <property type="protein sequence ID" value="CUN81893"/>
        <property type="gene ID" value="ERS852478_01149"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="259"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="4"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN81893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="590" mass="68831" checksum="EB69A37F2D780D03" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A5I9</accession>
    <name>A0A174A5I9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PAP2 superfamily</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">PAP2 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BWLFYP14_03031</name>
        <name evidence="7" type="ORF">ERS852478_01203</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381018.1">
        <property type="nucleotide sequence ID" value="NZ_WWVC01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83901">
        <property type="protein sequence ID" value="CUN83901"/>
        <property type="gene ID" value="ERS852478_01203"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_3" evidence="6">
        <location>
            <begin position="51"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN83901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="227" mass="26885" checksum="9BE7C3AD5836709A" modified="2016-09-07" version="1">MKRFISKYRHGLVIAVYSIIYILLFSYLEHRPVHSYHIVHTVFDDWIPFCEFFIVPYMLWFPYMILAVIYFIFFNKNKHEYYQLAFNLMMGMTVFLIVSYVYPNAQHIRPTEFPRDNIFTDIVKWLYSTDTPTNILPSIHVFNSLAIHMSLTNCETLRNKKFIKAASFTLTALIIMSTMFLKQHSVIDVCMGATLALFGFLVFYPRRVSVSSESVCFREVKRKKSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A5Y8</accession>
    <name>A0A174A5Y8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">regX3_3</name>
        <name evidence="11" type="ORF">ERS852478_01204</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199959.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83934">
        <property type="protein sequence ID" value="CUN83934"/>
        <property type="gene ID" value="ERS852478_01204"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="125"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN83934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="222" mass="25458" checksum="A5B93127744D3206" modified="2016-09-07" version="1">MIYLVEDDESIRELVIYTLKSQGFEAKGFERPSHFWKALEKEKPALLLLDVMLPEEDGICILKKLRMRPDTRKLPIIMLTAKSSEYDTVVGLDSGADDYIPKPFRMMELISRIRALLRRTEDDGAEEYQTGNLYVCPSRHIATVDKKNVNLTLKEYEVLCLLLKNSGTVLSRTQLLNQVWGYEFDGESRTVDVHIRTLRQKLGSAGELVETVRGVGYKINMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A6L2</accession>
    <name>A0A174A6L2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar biosynthetic protein fliU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fliU</name>
        <name evidence="1" type="ORF">ERS852478_01215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN84271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199966.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84271">
        <property type="protein sequence ID" value="CUN84271"/>
        <property type="gene ID" value="ERS852478_01215"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN84271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="400" mass="47543" checksum="012CEA3170E45EBB" modified="2016-09-07" version="1">MQYTFPNYYKEFSCIAGACPDTCCAGWQIVIDDQTLKKYQHFKGPFRNRLHNDIDWKEHVFCQYNRRCAFLNEENLCDIYTEAGPEMFCRTCRNYPRHIEEFEGLREISLSLSCPEAARILLSQKEKVHFITKEKKTKEEVYDDFDYFLFTALMDTRDMLIDIIQDRAVPMQKRLWKLLAAAHDFQLCVNKNELFKWEEIRRRHEDSGYGDGFCSKIYSRINADNIESCSAASACANTPEQLFKKMWKTVVPEMEVLRPGWQEYLKNCLTPLYNGNTDPQSDSGNLYSWQKSEFDFSYPDWQIQEEQLLVYWIYTYFCGAVYDDEIFAKVKMAVVCTLFIHELNVGTYLKNNRQFKLDDQICICYQFSRELEHSDLNLNRFEELMSEKEIFSFENLLKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A7A2</accession>
    <name>A0A174A7A2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Riboflavin biosynthesis protein RibBA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
                <shortName evidence="12">DHBP synthase</shortName>
                <ecNumber evidence="12">4.1.99.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">GTP cyclohydrolase-2</fullName>
                <ecNumber evidence="12">3.5.4.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">GTP cyclohydrolase II</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">ribBA</name>
        <name evidence="17" type="ORF">BWLFYP14_03012</name>
        <name evidence="14" type="ORF">ERS852478_01223</name>
        <name evidence="16" type="ORF">GT712_03870</name>
        <name evidence="15" type="ORF">GT728_00085</name>
    </gene>
    <organism evidence="14 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="15 20 21" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 21">BIOML-A1</strain>
            <strain evidence="16 20">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="12"/>
    <dbReference type="EC" id="3.5.4.25" evidence="12"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN84521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704014.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84521">
        <property type="protein sequence ID" value="CUN84521"/>
        <property type="gene ID" value="ERS852478_01223"/>
    </dbReference>
    <dbReference type="GeneID" id="66494050"/>
    <dbReference type="eggNOG" id="COG0108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00179">
        <property type="entry name" value="RibA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01283">
        <property type="entry name" value="RibBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016299">
        <property type="entry name" value="Riboflavin_synth_RibBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="13">
        <location>
            <begin position="208"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="DHBP synthase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="12">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="12">
        <location>
            <begin position="140"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="GTP cyclohydrolase II" evidence="12">
        <location>
            <begin position="202"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for GTP cyclohydrolase activity" evidence="12">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GTP cyclohydrolase activity" evidence="12">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="252"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="295"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="12">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="site" description="Essential for DHBP synthase activity" evidence="12">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN84521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL31630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZS88251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VUX66736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="399" mass="45130" checksum="C62154664446A248" modified="2016-09-07" version="1">MNGFDSVEEALEELRNGKIILVTDDPDRENEGDFICAAEFATTENINFMATHGKGLICMPMSEEYVRKLQFPQMVAENSDNHETAFTVSVDHISTTTGISAAERSVTAMKCVDENAKPEDFRRPGHMFPLLAKKNGVLERNGHTEATVDLCRLAGLKQCGLCCEIMREDGTMMRTSELRELAGKWNLKFITIKDIQNYRKCHDILVDRVTTTKMPTRYGEFMAYGFVNRLNGEHHVALVKGEIGDGENVLCRVHSECLTGDVFGSQRCDCGQQFAAAMAQIEEEGRGILLYMRQEGRGIGLINKLRAYELQEQGMDTLEANLALGFAGDEREYYIGAQILRNLGVKELRLLTNNPDKVYQLEEFGIRIKQRVPIQMNATAYDLRYLKTKQLRMGHILKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AL06</accession>
    <name>A0A174AL06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maltodextrin-binding protein mdxE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mdxE</name>
        <name evidence="3" type="ORF">ERS852478_01296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88225">
        <property type="protein sequence ID" value="CUN88225"/>
        <property type="gene ID" value="ERS852478_01296"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017758" evidence="2">
        <location>
            <begin position="30"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN88225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="455" mass="49984" checksum="EC13220CCBC79332" modified="2016-09-07" version="1">MKKRMYKIMALAMTAAMVVPMAAQTTAFAADDKEITYWNIAVESPDKDIVTAAVDKFNKETKSGYTVNQVAIQNDTYKEKLVIAMSSGECPDMYSSWSGGPMYEYIDSGFAQPIDDLLDQSDVKDKLLDAAIEQGSYNGHVYAIPYLNVSLAGIFYNKDMFKQYGLEEPKTLADLENICATLKENGITPFALANASKWTGSMYFMSLAARYGGLEPFQNAVAGTGKFTDDCFIKAGEKIQEWVNNGYFPDGVNSLSEDDGQAKQLMYQETAGMLLCGSWYTGTFQTDSEEFYQKIGWFPFPAIDDSDADPTIQIGTVGDQFISFNCEGDKLAAAFECATDHLSDEVADITYSNNKIVPVKDAGDHIKDPVVKEIFDAAQEASSIQLWYDQYLPTSVATAHLDGLQEVFGLTKTPQEAQEEMQKAMDEYLSTKSDSGAADDTAEEATDDAAADDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ANH8</accession>
    <name>A0A174ANH8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3 4">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dfrA</name>
        <name evidence="6" type="ORF">ERS852478_01324</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3 4"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580581.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89160">
        <property type="protein sequence ID" value="CUN89160"/>
        <property type="gene ID" value="ERS852478_01324"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
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    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001796">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN89160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="163" mass="18743" checksum="38CF72B56EFAEAF2" modified="2016-09-07" version="1">MNVIVAADQNWGIGKDNKLLVSIPADMKMFREETSGKVVVMGRKTLESFPNGLPLKNRTNIVITKNKDYDAKGAIVVHSIEEALEEIKKYPTEDVYCIGGDSIYEQMLPYCDVAHVTKIDFAYEADSHFPNLDEDDEWEITAESDEQTYFDLEYQFVKYERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AP37</accession>
    <name>A0A174AP37_9FIRM</name>
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        <submittedName>
            <fullName evidence="2">Predicted AAA-ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA-ATPase_like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN89248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="523" mass="60480" checksum="D4A9264A64435635" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AP79</accession>
    <name>A0A174AP79_9FIRM</name>
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        <submittedName>
            <fullName evidence="6">Probable ABC transporter ATP-binding protein HI_0664</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">ERS852478_01366</name>
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        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
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    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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            <end position="80"/>
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        <location>
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            <end position="109"/>
        </location>
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        <location>
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            <end position="187"/>
        </location>
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            <end position="213"/>
        </location>
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        <location>
            <begin position="56"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN90561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="250" mass="27247" checksum="1C8C1DBF685A6AE0" modified="2016-09-07" version="1">MSDTNEKSMQKSTVQKKMVNESTASYGAAATKKRRSAISIMGSLIGLVKPLLHIMLAAIILGTAGYLCAIFLTILAGQVIVHGLIAGGEGSVKTIITLMLIIAVLRGILHYAEQYCNHFIAFKLLAIIRHKVFAALRKLCPAKLEGRDKGNLISIITTDIELLEVFYAHTISPIAIAALTSLVMVFFIGRYHWLAGILALAAYLVVGVVIPMWNGKCGSQMGMEFRTNFGELNSFVLDSLRGLDETIQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B3V0</accession>
    <name>A0A174B3V0_9FIRM</name>
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        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulator</fullName>
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    <gene>
        <name evidence="2" type="ORF">ERS852478_01478</name>
        <name evidence="3" type="ORF">ERS852523_01059</name>
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    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
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    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95384">
        <property type="protein sequence ID" value="CUN95384"/>
        <property type="gene ID" value="ERS852478_01478"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26078">
        <property type="protein sequence ID" value="CUP26078"/>
        <property type="gene ID" value="ERS852523_01059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
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    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="12"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN95384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP26078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="86" mass="9782" checksum="2F04C378F5FBF0A1" modified="2016-09-07" version="1">MIKILLSKKLGELRLTQADLARATGIRPNTINELYHELTERVSLEHLDLICEALNCELDELIIRVPNKETSITHTRQGTQKSSDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BAN7</accession>
    <name>A0A174BAN7_9FIRM</name>
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        <submittedName>
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        </submittedName>
        <submittedName>
            <fullName evidence="4">Lysophospholipase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Plasmodium subtelomeric family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_00962</name>
        <name evidence="2" type="ORF">ERS852478_01515</name>
        <name evidence="3" type="ORF">GT712_12975</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000026">
        <property type="protein sequence ID" value="MZS89959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704305.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96745">
        <property type="protein sequence ID" value="CUN96745"/>
        <property type="gene ID" value="ERS852478_01515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="30"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN96745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS89959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX63476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="297" mass="34048" checksum="340A8C39F1E5B906" modified="2016-09-07" version="1">MKRICIAISSNDKDTTMHLEIYAPEYKGDLKGLIQICHGMTEYMGRYVEFAKYFTSRGYIVFGNDIISHGHSTTPRSSCLYINDWNDTVKDMVSAREYVVRKYPNLPIYLLGFSLGSFIVRTNADLTPYKKEILIGTGAQSAFLMRIMRTWIGKKYTGKMSCASDKIYDLMFGTYGKKFKGRPANYWLLTDNEKRREYADDSLVRQDVSPAFFCEFSKGMECASRNLKNPNNTIPTLFLYGKKDPVSGFGKGVRKVYKAYKENNPDTEIRSFPGTHDILHDSGYESVFKAIADYLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BB39</accession>
    <name>A0A174BB39_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN98231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200144.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98231">
        <property type="protein sequence ID" value="CUN98231"/>
        <property type="gene ID" value="ERS852478_01556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018273" evidence="1">
        <location>
            <begin position="30"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN98231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="118" mass="13130" checksum="731976BD3DEFB55E" modified="2016-09-07" version="1">MKKMLKRLCTGFLALATVVTALPTTPVHAESKQYWTESAERVGIIEKVMNDGSIGSTFNEGYMKVEGETAYCIDINTDFKNGYKTRADASSRMSADQISDVALCSFLICFYHEKTIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BGX1</accession>
    <name>A0A174BGX1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008688043.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99914">
        <property type="protein sequence ID" value="CUN99914"/>
        <property type="gene ID" value="ERS852478_01580"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046113">
        <property type="entry name" value="DUF6050"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19517">
        <property type="entry name" value="DUF6050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN99914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="103" mass="11699" checksum="36063D07DDC84DCF" modified="2016-09-07" version="1">MTIGDVIKKSILPLAFMVFWFWMTKTIMKVSGQTDWFWWVFIAGLPFGIHKMRLILIPRGMDTTATLGMAALSVIIGALIGSIMIPVYVIRAIYVFIRYVIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BQ65</accession>
    <name>A0A174BQ65_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008688148.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01825">
        <property type="protein sequence ID" value="CUO01825"/>
        <property type="gene ID" value="ERS852478_01635"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO01825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="123" mass="14511" checksum="1BE4D1503763582A" modified="2016-09-07" version="1">MRYEDSMKGVADQIIKEQQRASKIKNNPEEFHWHDEYATLNFFRFICKNIGNLGNGEIEKMVTRLKSIDQKAVENHVNGAVWAFDYDKMFCVLMENEICRKVCEKNKYNSWTKLIGQYCISMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C0N9</accession>
    <name>A0A174C0N9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tyrosine recombinase XerD</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xerD_2</name>
        <name evidence="8" type="ORF">ERS852478_01751</name>
        <name evidence="9" type="ORF">GT712_12110</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06427">
        <property type="protein sequence ID" value="CUO06427"/>
        <property type="gene ID" value="ERS852478_01751"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="7">
        <location>
            <begin position="6"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="124"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO06427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="308" mass="36308" checksum="DA211CEAAE3C51E0" modified="2016-09-07" version="1">MKNDSLLFYRIVRDFLTIYLPKQRGASQNTAKSYRDTLNLFIDYISASQGTPLADISFKCISREPVESFLMWLETDRGYSVNSRNQRMCAVKSFLRYAAEKDKILMPLFLDVKVIPKKKDTRVREIEFFSESALKAILEQPDRNKKNGQRDLFFMILMYDTGARAQEILDLRLCNIHMDGKNPYVVITGKGAKTRNVPIMEKTCKHLKSYLHRFHIEDNPEEYLFYIERKGIRSQMSIDNVEKFVARYGKKAQETSTDVPEHLYPHMWRHSRAMHLYRNGMPLPLVAEWLGHAKMDTTRRFMQMLIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C2L8</accession>
    <name>A0A174C2L8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07751">
        <property type="protein sequence ID" value="CUO07751"/>
        <property type="gene ID" value="ERS852478_01793"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50323U8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018871" evidence="1">
        <location>
            <begin position="32"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="107"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="186"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="257"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO07751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="322" mass="35533" checksum="95EDDC6C7C387F08" modified="2016-09-07" version="1">MKKRKNIAIPMILAATIAAVSVPCSSQTVMASDTYQVGVSKGYLALRSAMDYDSSNEIGELYSGDTVEVTEYTTSDYWYVYSPKLNLSGYVNNDYLYFLSSQPTSSSGSYTVSVAKGYLALRSTKAYDSSNEIGQLYSGDTVTVSDSSDPQYWYVYSPKLNLSGYVNKDYLYYSGDTAASAQSSSGDSRTVSVAKGYLALRSAKAYDSSNEIGQLYSGDTVQLIDTSDSQYWYVYSQKLGKNGYVNKDYLIGGTTTYATRTVSVATGYLALRSAKAYDSSNEIGQLYSGDTVQLVDTTDAQYWYIYSQKLCKYGYVNKDYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C5A4</accession>
    <name>A0A174C5A4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stage 0 sporulation protein A homolog</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpfC_2</name>
        <name evidence="11" type="ORF">ERS852478_01822</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08711">
        <property type="protein sequence ID" value="CUO08711"/>
        <property type="gene ID" value="ERS852478_01822"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="269"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO08711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="392" mass="43976" checksum="5DE559FE51514718" modified="2016-09-07" version="1">MSRNRHAFNEMRAESRAKTNFLSRMSHDIRTPLNGIIGLLKIDETHFEDKELIQENHKKMKIAADYLLSLINDVLQMSKIEEGHIVLTHEYICLKDLVYEIESIITHKAADEDIQWIYEKNKEDVPYPYVYGSSLHLRQIFLNIYGNCIKYNQPGGKITTVMEAADVHDGICTYRWTISDIGIGMSPEFLSHIFDPFSQEKTDARSVYQGTGLGMAITKGLIEQMNGSIEVTSQVGVGSVFVITIPFEIAQEQKKDEEIAEKYDIRGLHLLAAEDNELNAEIIEMLLTDDGAKVTVAKNGRQAVEHFENNPPGTFDAILMDVMMPVMDGIAATKAIRAMDRADAKTIPIIAMTANAFEEDAKRCLAAGMTAHLAKPFQIEDVEKTIVECCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C7X9</accession>
    <name>A0A174C7X9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized oxidoreductase ybiC</fullName>
            <ecNumber evidence="2">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybiC</name>
        <name evidence="2" type="ORF">ERS852478_01795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200266.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07806">
        <property type="protein sequence ID" value="CUO07806"/>
        <property type="gene ID" value="ERS852478_01795"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="PTHR11091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="SSF89733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO07806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="376" mass="41374" checksum="14431AEBF01F2E1E" modified="2016-09-07" version="1">MGYVKWSYDTLNTFCHDVFRKFGFNEEETNIIKDVLLTADLYGIESHGMQRMVRYDKGIEKGTIHPDAKPEVVFETPVSAVIDGHDGMGQLISHFAMEKAIEKAKKTGVGFVSVRNSNHFGIAGYYAEMASKQGLLGMACTNSEAIMVPTFGRKAMLGSNPIAVAMPAEPYPFLFDCSTTVVTRGKLEMYNKMGKPLPQGWALGANGQESTDAPDVLANIVAKRGGGIMPLGGNKEVNGSHKGYGYGMLCEIFSSIFSMGVTSDKCCTFKDKTGICHGFAAIDPAIFGNADDIRAHFSEYLETLRQSPKAEGAEQIYTHGEKEVFAEKERRENGIPVNDNTMVELANLCNYLKVDFDSYFKGYELPKDSKFFSGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C8B0</accession>
    <name>A0A174C8B0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aliphatic sulfonates-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ssuA</name>
        <name evidence="3" type="ORF">ERS852478_01815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200297.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08489">
        <property type="protein sequence ID" value="CUO08489"/>
        <property type="gene ID" value="ERS852478_01815"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018999" evidence="1">
        <location>
            <begin position="29"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="53"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO08489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="337" mass="36662" checksum="0D3CAB237E0FFED7" modified="2016-09-07" version="1">MRKTWKKLAAMAVTASMVICGGAMGVSAATEEEKPEKVTVNVAYMPDYASLNGLISAIELGYFDDENIDVQLTEFSDGPTIIQAMESGSIDVGYIGQGAHKLCINGKADIFALAHVSNGDAVIGSKEKGTDTIEGLKGKTIAYSSGTSSEDILNKTLAKGGMTMDDITAMDMDATNIVTAMLSGSVDACATWVPNSLKVLEELGDDGVQLADNKTFIDQTVSLASWIAMPKYAEENHDVLVRFARALYKGFDYRADHSHDDEVCGWIADKIKLEKNSLLDQVEVADWTTSEFIRDHMDDVKGYYELQQKSFVESGDCEETPVDNYVLFDVMEEACAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C9Y0</accession>
    <name>A0A174C9Y0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative aliphatic sulfonates transport permease protein ssuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ssuC_1</name>
        <name evidence="7" type="ORF">ERS852478_01817</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200299.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08548">
        <property type="protein sequence ID" value="CUO08548"/>
        <property type="gene ID" value="ERS852478_01817"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="65"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO08548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="260" mass="28491" checksum="C3889014D84CEB13" modified="2016-09-07" version="1">MEKKKKGVMQSIPGWAWVLISLAAAILLWYALSINPKTARSFPFIPAILEAAKRMIDNGALGQDFCSSMISILAGFALGFITAVPIAFLMAWYLPVRGVLEPWIQFIRNIPPLAYVPLVVITAGVGRKPQIIVIWIATFLIMTVTIYQGVRNIDNTLVKAARVLGAKDRDIFVKVIFPATTPFILTAVRLGISVALTTLIAAETTGATAGLGMRIRSLANSFETAGMLMYIIIIGIIGLVMEKIIKFLEGRLTGWQEKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CDF3</accession>
    <name>A0A174CDF3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aliphatic sulfonates import ATP-binding protein SsuB</fullName>
            <ecNumber evidence="1">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ssuB_1</name>
        <name evidence="1" type="ORF">ERS852478_01892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11561">
        <property type="protein sequence ID" value="CUO11561"/>
        <property type="gene ID" value="ERS852478_01892"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO11561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="67" mass="7502" checksum="D41C5ABCACAD3052" modified="2016-09-07" version="1">MKQGVAIARACSAHPEVLLLNEPFSALDAQTRIKLQSGLLDAWEQEKNYKEVAKLVNLLHENCFHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CFJ4</accession>
    <name>A0A174CFJ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin:thioredoxin reductase</fullName>
            <ecNumber evidence="5">1.8.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Ferredoxin-thioredoxin reductase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">ERS852478_01874</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [thioredoxin]-dithiol + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42336"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.7.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of subunit A (variable subunit) and subunit B (catalytic subunit). Heterodimeric FTR forms a complex with ferredoxin and thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ferredoxin thioredoxin reductase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.8.7.2" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11029">
        <property type="protein sequence ID" value="CUO11029"/>
        <property type="gene ID" value="ERS852478_01874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016730">
        <property type="term" value="F:oxidoreductase activity, acting on iron-sulfur proteins as donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004209">
        <property type="entry name" value="FTR_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036644">
        <property type="entry name" value="FTR_bsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02943">
        <property type="entry name" value="FeThRed_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57662">
        <property type="entry name" value="SSF57662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO11029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="62" mass="7180" checksum="B47E490BFA7A0FC6" modified="2016-09-07" version="1">MKIKLNPDQEVVQTIREGLKRTGGYCPCRIERTEATKCICQEFKEQIADPDFEGVCHCMLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CHT7</accession>
    <name>A0A174CHT7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Domain of uncharacterized function (DUF477)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_01918</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200436.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12487">
        <property type="protein sequence ID" value="CUO12487"/>
        <property type="gene ID" value="ERS852478_01918"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019182" evidence="6">
        <location>
            <begin position="35"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="7">
        <location>
            <begin position="44"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO12487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="280" mass="30979" checksum="9AEA3C838DC36E92" modified="2016-09-07" version="1">MLKKKIIPVFLASALTVSGTTGFVTEAFSENVYAAEEVHTERLADFADLLDDGQEEELEAKLDQVSEDYGCDVVVVTEEALDGAVPQDYADDFFDYNDYGMGEDKSGILFLITMSERKWCISTHGEAIQIFTDAGQEYMTDNFGSYLSDGEYYEGFMKFADLCEEFIIQAQSGEPYDVENLPEETIPFYMIFLISLVVGFVIALIVTGVMRSRMKTVHMKPDAADYMKDGSLHINRSRDIFLYHQVTRTAKPKEESSGGGGSSTHTSSSGETHGGSSGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CK78</accession>
    <name>A0A174CK78_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Capsular polysaccharide phosphotransferase SacB</fullName>
            <ecNumber evidence="7 9">2.7.-.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Capsular polysaccharide phosphotransferase cps12A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sacB</name>
        <name evidence="9" type="ORF">BWLFYP14_02217</name>
        <name evidence="7" type="ORF">ERS852478_01913</name>
        <name evidence="8" type="ORF">ERS852523_01967</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
            <strain evidence="8 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the stealth family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="7 9"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000018">
        <property type="protein sequence ID" value="CUP54438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055151311.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000004_gene1953"/>
    <dbReference type="EnsemblBacteria" id="CUO12208">
        <property type="protein sequence ID" value="CUO12208"/>
        <property type="gene ID" value="ERS852478_01913"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP54438">
        <property type="protein sequence ID" value="CUP54438"/>
        <property type="gene ID" value="ERS852523_01967"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031358">
        <property type="entry name" value="Stealth_CR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021520">
        <property type="entry name" value="Stealth_CR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031356">
        <property type="entry name" value="Stealth_CR4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17101">
        <property type="entry name" value="Stealth_CR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11380">
        <property type="entry name" value="Stealth_CR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17103">
        <property type="entry name" value="Stealth_CR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0270">Exopolysaccharide synthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Stealth_CR1" evidence="5">
        <location>
            <begin position="3"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR2" evidence="4">
        <location>
            <begin position="37"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR4" evidence="6">
        <location>
            <begin position="287"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO12208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP54438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX65852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="344" mass="41349" checksum="C62DDC60B98EA7AC" modified="2016-09-07" version="1">MDKIDFVLPWVDGSDSAWIKQRNEYLGIKNDQTQDSRFRDWENLQYWFRGVEKFAPWVNHIYFVTWGHIPSWLNTDHPKLTVVKHEDYIPKQYLPTFSSHPIELNMHRIRGLSEQFVYFNDDTFIINKMEPEDFFRNGLPRDYCIETALVQDDINNPFACILMNNAALVNMHYSKREVIGRNWKKWFHPAYGKMVFRNMLMLPYREFSSFKYSHISSSFLKSTFEEVWREEGEVLDRVCRTRFRSRGDVNQYVMKYWQYMEGKYEPQSPKIGKFFTIGLHDRQIHDVLRNQKCKILCINDTENIGDFRQQKRNIKDSFESILPEKSAFELSYKDSGGMYDKKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CQS2</accession>
    <name>A0A174CQS2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Domain of uncharacterized function (DUF3825)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_00408</name>
        <name evidence="2" type="ORF">ERS852478_01988</name>
        <name evidence="3" type="ORF">ERS852523_00095</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO96685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2260"/>
    <dbReference type="EnsemblBacteria" id="CUO15367">
        <property type="protein sequence ID" value="CUO15367"/>
        <property type="gene ID" value="ERS852478_01988"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96685">
        <property type="protein sequence ID" value="CUO96685"/>
        <property type="gene ID" value="ERS852523_00095"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024437">
        <property type="entry name" value="DUF3825"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12873">
        <property type="entry name" value="DUF3825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3825" evidence="1">
        <location>
            <begin position="23"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO15367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO96685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX62298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="251" mass="29541" checksum="2BE84B9D4838EB8C" modified="2016-09-07" version="1">MINLFDFTYCGDYNRQIQNLARMVPEKWSFSDTDDNGILKGYLEHTFKRLYEEQKVWEKKNYAIFNTGLFNYYYQPIYAYFIPNLVPDRQPWFLDGFYTEYYLLKEGITCLPEKACYVENPSDLVFDTKLPVIPQYEHIFGDEENAARLPKEVRDSSMKMQLFDGALKQTKRMLEADYRTAIPQYYNHSIQLLLPICLRHPGKPDLALACMKTSDGSKYLGRTCLTLRMAYHNARLLARVDRSWLMTSVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CYH5</accession>
    <name>A0A174CYH5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Recombinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Recombinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02371</name>
        <name evidence="2" type="ORF">ERS852478_02073</name>
        <name evidence="4" type="ORF">GT712_14170</name>
        <name evidence="3" type="ORF">GT728_13870</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO18097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000035">
        <property type="protein sequence ID" value="MZL34261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000030">
        <property type="protein sequence ID" value="MZS90184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX66001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380727.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18097">
        <property type="protein sequence ID" value="CUO18097"/>
        <property type="gene ID" value="ERS852478_02073"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Recombinase" evidence="1">
        <location>
            <begin position="170"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO18097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="535" mass="61677" checksum="8ADDE387DC873A96" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7B0</accession>
    <name>A0A174D7B0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20179">
        <property type="protein sequence ID" value="CUO20179"/>
        <property type="gene ID" value="ERS852478_02121"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO20179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="83" mass="9629" checksum="2A5CA80282C28E13" modified="2016-09-07" version="1">MQDDTLYNMTDNTEYQANLFAADLLIEDEEIEDMVQNEDLDYFGLCSSLNATPELMSFKLYSLTKRGQAYHMPMEIQSNFLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DJJ9</accession>
    <name>A0A174DJJ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Domain of uncharacterized function (DUF3784)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200640.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24509">
        <property type="protein sequence ID" value="CUO24509"/>
        <property type="gene ID" value="ERS852478_02245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017259">
        <property type="entry name" value="UCP037672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12650">
        <property type="entry name" value="DUF3784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO24509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="119" mass="13221" checksum="31CBDB4F6283283B" modified="2016-09-07" version="1">MWFVWVMWGIVTISIIATIILMTGKGSKFVTGFNTKSTEERAEYDSKKVSKQAGIFMILIDVGLIALVSYIQFRAVPAIQNNTISNYGTEITIVSLGICAYIILVAMIAVIRGFKYSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DKJ3</accession>
    <name>A0A174DKJ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA 2-thiocytidine biosynthesis protein TtcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ttcA</name>
        <name evidence="2" type="ORF">ERS852478_02295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200689.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26091">
        <property type="protein sequence ID" value="CUO26091"/>
        <property type="gene ID" value="ERS852478_02295"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="13"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO26091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="394" mass="45283" checksum="59D1FA207DD119FA" modified="2016-09-07" version="1">MNTISVEELEKIDSSKITIVDVRPADQYSRGSFPGAVNIPLDEFEERMESVDREKMVYVLCHTGDRSRDCVEKLSDAGYEAVNIEGGYRAYLRLSLSRFMENDAKEQKELKTKEIEHSIIKTFRKTVWRPFTKALNEYQLIQEGDKIAVCISGGKDSMLMAKLLQELKRHGKIHFELVFLVMNPGYNADNWKIIQDNAELLGIPLTVFESDIFDTVAEIENNPCYLCARMRRGYLYSHAKELGCNKIALGHHFDDVIETILMGMLYSGKVETMMPKLHSQNFEGMELIRPMYLIKESAIKAWRDTNGLHFIQCACRFTENCVSCGGGRGSKRDEMKELVAQFRNTSSVIETNIFNSVRDINLRTVMGYHKDGEYYNFLDDYDQRGNKGVDKDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DMS7</accession>
    <name>A0A174DMS7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">4-hydroxyphenylacetate decarboxylase activating enzyme</fullName>
            <ecNumber evidence="11">1.97.1.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="13">Glycyl-radical enzyme activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hpdA</name>
        <name evidence="15" type="ORF">BWLFYP14_01568</name>
        <name evidence="11" type="ORF">ERS852478_02322</name>
        <name evidence="12" type="ORF">ERS852523_01619</name>
        <name evidence="14" type="ORF">GT712_12750</name>
        <name evidence="13" type="ORF">GT728_12285</name>
    </gene>
    <organism evidence="11 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 16">2789STDY5834863</strain>
            <strain evidence="12 17">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="13 19 20" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 20">BIOML-A1</strain>
            <strain evidence="14 19">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="15 18" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:61976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="Rhea" id="RHEA-COMP:15993"/>
            <dbReference type="Rhea" id="RHEA-COMP:15994"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.-" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP43874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000029">
        <property type="protein sequence ID" value="MZL33957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705586.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000086_gene4001"/>
    <dbReference type="EnsemblBacteria" id="CUO26932">
        <property type="protein sequence ID" value="CUO26932"/>
        <property type="gene ID" value="ERS852478_02322"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP43874">
        <property type="protein sequence ID" value="CUP43874"/>
        <property type="gene ID" value="ERS852523_01619"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012839">
        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="19"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO26932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP43874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL33957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS89916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VUX64714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="263" mass="29607" checksum="5229B078CC2FA32D" modified="2016-09-07" version="1">MDYLDTKGRVFDVQKYSIHDGPGIRTIVFLKGCVLRCKWCCNPESQEYKIQTMKVQGEDKVIGRDVTVREMIEEVEKDRVYYYRSGGGMTLSGGECLCQPEFAGALLRAAKERGISTAIESMACAKWETIETILPYLDTYLMDIKHTNPAKHKEFTGRSNELMMENARKVALSGKTRLVIRVPVIPTFNDTVEEIQGIARFADTLPGVDKIHLLPYHRLGQDKYEGLGRPYLMGNVEPPSKEHMETLKKAVHAVCGLDCQIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DW17</accession>
    <name>A0A174DW17_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">coaE</name>
        <name evidence="3" type="ORF">BWLFYP14_00143</name>
        <name evidence="2" type="ORF">ERS852478_02393</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29782">
        <property type="protein sequence ID" value="CUO29782"/>
        <property type="gene ID" value="ERS852478_02393"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO29782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="200" mass="23171" checksum="EB3BB1B606680F71" modified="2016-09-07" version="1">MMITIGITGGVGAGKSTVLDFLEEKYQAYVMKADEIGHLVMEPGQSCYEPVIALFGRQIIKNDKTIDRRQVSDVVFSHPELLEKLNQIIHPAVKQYIREQLAVKKQQEQKICVVEAALLLEDHYQEFCDTIWYIHTDEEIRIRRLMENRGYTREKSVSIIASQAPETFFRENADYVVVNNGDFAQTRRQIEEGIRKYETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DXS5</accession>
    <name>A0A174DXS5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cysG</name>
        <name evidence="10" type="synonym">nasF</name>
        <name evidence="10" type="ORF">BWLFYP14_00129</name>
        <name evidence="9" type="ORF">ERS852478_02408</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381478.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30254">
        <property type="protein sequence ID" value="CUO30254"/>
        <property type="gene ID" value="ERS852478_02408"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="HEM4" evidence="8">
        <location>
            <begin position="267"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO30254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX66576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="501" mass="54410" checksum="5B961B363B04CB3A" modified="2016-09-07" version="1">MAAGKVWLVGAGPGDIGLFTLKGAAVLQQADVVVYDSLVGEGVLAKIPEHARLINVGKRANHHTMVQEDINKVLLEEAEKGNKVVRLKGGDPFLFGRGGEELELLSENGIPYEIVPGVTSPISVPAYNGIPVTHRDFCSSLHIITGHKRAGQEYDIDFKALTQTKGTLVFLMGIAALEDICKGLLAGGMDPDMPAAVLQKGTTAGQKRVVATVGTLKEEVDRQGIETPAIIVVGKVCSLADKFAWYEKLPLAGWKVLVTRPRQHISKTADLLRQKGAEVLELPSICTVPVEDNGRLYEAFEKLDTYQWIIFTSPAGVEIFFDEMDRKEMDVRSLGQAKIAVIGEGTKKKLKEHHLLADFVPGVYDGDTLGAELAKQLQGNEKILIPRAEAGNKKLTELLEQTGAKVDDIATYTTCYEKSRLIDEKKELETGSVDCVVFTSASTVKGFVEGTKGLDYTKVKAACIGKQTKAAADAYGMQTRMAKKATIESLIELVEEMKQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E365</accession>
    <name>A0A174E365_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalamin biosynthesis protein CbiG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_00106</name>
        <name evidence="4" type="ORF">ERS852478_02430</name>
        <name evidence="5" type="ORF">GT728_01850</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL31977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057525.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30926">
        <property type="protein sequence ID" value="CUO30926"/>
        <property type="gene ID" value="ERS852478_02430"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021745">
        <property type="entry name" value="CbiG_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021744">
        <property type="entry name" value="CbiG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002750">
        <property type="entry name" value="CobE/GbiG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036518">
        <property type="entry name" value="CobE/GbiG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038029">
        <property type="entry name" value="GbiG_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01890">
        <property type="entry name" value="CbiG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11761">
        <property type="entry name" value="CbiG_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11760">
        <property type="entry name" value="CbiG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159664">
        <property type="entry name" value="SSF159664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159672">
        <property type="entry name" value="SSF159672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiG_N" evidence="2">
        <location>
            <begin position="51"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="CbiG_mid" evidence="3">
        <location>
            <begin position="136"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="CbiG_C" evidence="1">
        <location>
            <begin position="246"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO30926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL31977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="373" mass="40294" checksum="D806998FE42CD863" modified="2016-09-07" version="1">MKVALICFSLTGQQTGERLCRGLEAAGMTAELDKKSKYLLDSIQISTSAWAGEKFSDSDALIFIGATGIAVRSIAPYVASKKSDPAVLVVDECGKFVISLLSGHLGGANELALKTAEILEAIPVVTTATDLHHRFAVDVFAKKNNCNIFNMKAAKEVSATLLAGKKVGFYSEFPTDGELPEGLIRCDEYGNSVSSMDDRSEEETQKSSDFDGTGTDCTNIDCGVAVTVHTSCNPFISTTQVVPKCLTLGMGCRKDKDARGIAEAAQKVLDRSGFHKEAFEQIASIDLKKEEKGILSLSQDWQIPFVTYTEEELKQVPGEFTPSPFVKKITGVDNVCERSAVLASGNGRLLQRKTGENGVTTAVAAREWRIHFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EBI2</accession>
    <name>A0A174EBI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA segregation ATPase FtsK/SpoIIIE and related proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003062524.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35031">
        <property type="protein sequence ID" value="CUO35031"/>
        <property type="gene ID" value="ERS852478_02546"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="214"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="231"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO35031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="464" mass="53428" checksum="D54FF9A00E886290" modified="2016-09-07" version="1">MRMIWNKGHRIRASDKHLVYHFSIGTLLFVFMAVLLLLNIKQLMRTDWEHFSLLENGLTLSPYNFITVLIATGVCALVAFLYYRFCYDSFKKLLHRQKLARMILENKWYEADTVQDSGFFTDLQSRSREKIVWFPKIYYQMEKGLLHIRCEITLGKYQDQLLRLEDKLESGLYCELTDKTLHDGYIEYTLLYDMIANRITIDEVWAENGCLRLMKNLVWEYDALPHALIAGGTGGGKTYFLLTLIEALLHTNAVLYILDPKNSDLADLGTVMPNVYHTKEEMIDCVNAFYEGMVRRSEEMKQHPNYKTGENYAYLGLPPCFLIFDEYVAFFEMLGTKESVSLLSQLKKIVMLGRQAGYFLIVACQRPDAKYFSDGIRDNFNFRVGLGRISELGYGMLFGSDVKKQFFQKRIKGRGYCDVGTSVISEFYTPLVPKGHDFLQTISSLAQARQDGTATCEAKGDGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EHT4</accession>
    <name>A0A174EHT4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RelA_SpoT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO37251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37251">
        <property type="protein sequence ID" value="CUO37251"/>
        <property type="gene ID" value="ERS852478_02623"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="2">
        <location>
            <begin position="233"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO37251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="379" mass="44241" checksum="E0012FD7A9BAB5B6" modified="2016-09-07" version="1">MFSACLIEEYGDIFEFPSEKHKHAITSMLYFIDGNSDDINQLEEILVLDNKNTVRLKNLAAVLAVGNQLAELKNTNLDLNYEDFDKYNSEEIVGFVERNVVRSIAVKDGKLVIEAGGSDSAYALIERKVNLIINNYEKIFRSLTHGSGDNTGLFGIDSIELKCVLSAENSKKIYLNKEIEESWTEEDIELFNKLSFEERVFYADYLSTEFEITKFLVDFAKTNKAVLAGLEYRVKSPKSLYNKLYQRVEKSFFDSIADVIRYTVILEPKEYVEQIRSVTDALYEKNWKIYSLKNYWVNDSFPYNGVNAKFKNSRNYRIEIQFHTQESFDVKMSEEDHKLYEQRRVLEPGCDEYNRILQLQLKLYSDMEYPENIADLEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EQY6</accession>
    <name>A0A174EQY6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Neopullulanase 1</fullName>
            <ecNumber evidence="3">3.2.1.135</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tvaI</name>
        <name evidence="3" type="ORF">ERS852478_02700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.2.1.135" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200904.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000070.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40244">
        <property type="protein sequence ID" value="CUO40244"/>
        <property type="gene ID" value="ERS852478_02700"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031216">
        <property type="term" value="F:neopullulanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02857">
        <property type="entry name" value="E_set_CDase_PDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004185">
        <property type="entry name" value="Glyco_hydro_13_lg-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02903">
        <property type="entry name" value="Alpha-amylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="144"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO40244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="701" mass="81256" checksum="214B353E9E989BD4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ETZ3</accession>
    <name>A0A174ETZ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200889.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41572">
        <property type="protein sequence ID" value="CUO41572"/>
        <property type="gene ID" value="ERS852478_02749"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO41572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="278" mass="31768" checksum="569860B8AFC3E98F" modified="2016-09-07" version="1">MQEKNSVVLMNFSGIYREEEFWKNRQVSWIELQDVCGTNCYCDEEAIAEINKRTENYPTAGIHFIDSGNYHYMTRLWLTRMDQPFCLLVYDNHTDMQPPAFGGILSCGGWIAAALEELENLKYVILVGPDEAAYEQVDENLKDRVIFLSREKLQVMNDEERNWFLRETVSEVCNWRKSEGLQEDAEKFLPLYISVDKDVLCTEDAQTTWSQGDMRLTTLVSGVQTVLECAKESSGKIAGVDICGEADAEAVHENEANDYANEKLLEVFEGLFGKSDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZ43</accession>
    <name>A0A174EZ43_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41310">
        <property type="protein sequence ID" value="CUO41310"/>
        <property type="gene ID" value="ERS852478_02740"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO41310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="38" mass="4221" checksum="C51B2D9FA7A78242" modified="2016-09-07" version="1">MMDYRKNDVTGYNSLSQTAVGNGCLYIYIEVNQTAADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F170</accession>
    <name>A0A174F170_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">yehU_6</name>
        <name evidence="10" type="ORF">ERS852478_02805</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43451">
        <property type="protein sequence ID" value="CUO43451"/>
        <property type="gene ID" value="ERS852478_02805"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="321"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="485"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO43451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="601" mass="69077" checksum="C32937C83068363E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F8E5</accession>
    <name>A0A174F8E5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">DNA repair and recombination protein RadB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02903</name>
        <name evidence="4" type="ORF">GT712_17975</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000055">
        <property type="protein sequence ID" value="MZS90884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993198.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46602">
        <property type="protein sequence ID" value="CUO46602"/>
        <property type="gene ID" value="ERS852478_02903"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="41"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO46602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="361" mass="40205" checksum="88321F1704897798" modified="2016-09-07" version="1">MNMNEKNKVENCRIEPKLKLINMDSVEVEQIEWLLYPFIPYGKVTIIQGDPGEGKTTMVLQIIAKLTRGEPIFPVTDTTMKIKEKRSDEVDSGNDGLDGEDNMQEQSSMSPVHVIYQTAEDGLGDTIKPRLLAAGADCSKVMVIDDSDQPLTMADVRLEEAIVQTKAKMVVLDPIQGFLGANVDMHRANEIRPLMKRIAVLAEKYHCAVILIGHMNKNSNGKSSYRGLGSIDFQAAARSVLIVGRVKEEPEVRVVCHTKSSLAPEGMSIAFRLDKNNGFEWIGEYDISADELLNGDGRGQKSQKAKEFLLEILANGGMAQKKIAEEAEGRGIKGKTLWNAKRELEIDSVKRGKQWYWMLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FAA4</accession>
    <name>A0A174FAA4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_03414</name>
        <name evidence="1" type="ORF">ERS852478_02898</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46497">
        <property type="protein sequence ID" value="CUO46497"/>
        <property type="gene ID" value="ERS852478_02898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO46497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX67137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="73" mass="8693" checksum="D9E945BE2C469DA2" modified="2016-09-07" version="1">MIGDIRKKGYVLPLGMNSMQKFVDTGFKFKEIVIKEQHNCRSTDYWEGKERKFLMLAHEYIFILEKADDHNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FDV9</accession>
    <name>A0A174FDV9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyn operon transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cynR_4</name>
        <name evidence="4" type="synonym">cynR_2</name>
        <name evidence="3" type="ORF">ERS852478_02959</name>
        <name evidence="4" type="ORF">ERS852523_01492</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
            <strain evidence="4 6">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP39908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706289.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000028_gene204"/>
    <dbReference type="EnsemblBacteria" id="CUO48333">
        <property type="protein sequence ID" value="CUO48333"/>
        <property type="gene ID" value="ERS852478_02959"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP39908">
        <property type="protein sequence ID" value="CUP39908"/>
        <property type="gene ID" value="ERS852523_01492"/>
    </dbReference>
    <dbReference type="GeneID" id="66493660"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO48333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP39908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="297" mass="33749" checksum="7FEF54AC0B9E2E12" modified="2016-09-07" version="1">MILDYYRIFYYVAQYKSFSKAADVMGNNQPNITRCMNILENELGCKLFIRSNRGVQLTIEGERLFEHVSIAIEQLVSGENELLKDKGLESGLVNIGASEIALRLFLLNELEVFHHRYPHVKLRISNHSTPQAVQALENGLVDFAVVTTPVALKKPLQRIPLYSFREILIGGEEYAETASNKHCLQDLQDIPLIGIAPGSSTRELYTQYFMRHNLPFSPDMEVATTDQIFPMVQHNLGIGFFPEELAAEHIAQGKIVQIPIEEPLPERKICLIRNVKRPQSIAARSLEEHLTSHRETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FMJ1</accession>
    <name>A0A174FMJ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201093.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50941">
        <property type="protein sequence ID" value="CUO50941"/>
        <property type="gene ID" value="ERS852478_03040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO50941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="73" mass="7861" checksum="B0BE9FBFC3B8D3DE" modified="2016-09-07" version="1">MSRNIKGGFLTLSGVVGIVGMIIAAMQNPATAWVTPPGRMIVSILENGLLIPTVLFLVPFIYGLYILLTEKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FNH6</accession>
    <name>A0A174FNH6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NodB homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_03056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379935.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51802">
        <property type="protein sequence ID" value="CUO51802"/>
        <property type="gene ID" value="ERS852478_03056"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021838" description="NodB homology domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="335"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO51802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="484" mass="55017" checksum="51D8B5C5CF0CB274" modified="2016-09-07" version="1">MRKRIACVTAAILSISLGVSGCGLIPFEQDIPFLSSRAENAETEKKTEQQTIDEQDADTEKSTEDTQQDDGLNEGEQTDNEDTEEADEKQENPMEQAALMAVQYDYDGAIELLKSQPDYESNTDMQSAVSDYENTKATCTEYPLEQITHVFFHTLIKDTARAFDGDSDSNGYNQYMTTIDEFNKIIQSMYDKGYVMVSPHDMAVINEDGTMSRGSIMLPPGKIPFVLSQDDVSYYHYMDGDGFASKLVVDSNGEVKNEYIEDDGSVSTGDYDMVPLIDTFVKEHPDFSYHGRKGILAMTGYDGVLGYRTDIAYKTGKKLQDDQKKFLEDHPDFNYKQEVKNAKKVAKAMKAEGWEFASHTWGHKDVAATSLDDLKRDDKKWKKYVAPILGETDMIIFAFGADIGSWEGYSADNEKYEFYKSQGYRYFCNVDSSQYFVQITDDYFRQGRRNLDGYRMYYNPEMLSDLFDVSEVWDSSRPTPVPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FNK4</accession>
    <name>A0A174FNK4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pstC</name>
        <name evidence="11" type="ORF">ERS852478_02995</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO49715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201064.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49715">
        <property type="protein sequence ID" value="CUO49715"/>
        <property type="gene ID" value="ERS852478_02995"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="66"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO49715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="285" mass="30384" checksum="E85C3D54D5181218" modified="2016-09-07" version="1">MNHFKEKAMKCVFLIAACTSVLAVFLICAFLFANGVPAIGKIGPLKFLLGTKWKPSNDIFGILPMIVASIYVTAGAILLGVPIALFTSVFMARYCPKKIYRPLKSGIELMAGVPSIVYGFFGLILIVPLIRQIFGGTGTSMLAACVLLGMMILPTIIGVTESAIRSVPDSYYEGSLALGATKERSIFFVMLPAAKSGILAAVVLGIGRAIGETMAVVMVAGNQPRMPQGILKGVRTMTANIVTEMGYATGLHREALIATAVVLFIFILIINLSLSLLNRRAEHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G141</accession>
    <name>A0A174G141_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acidobacterial duplicated orphan permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">FtsX-like permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BWLFYP14_00677</name>
        <name evidence="8" type="ORF">ERS852478_03140</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO54549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000015">
        <property type="protein sequence ID" value="VUX62928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201191.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54549">
        <property type="protein sequence ID" value="CUO54549"/>
        <property type="gene ID" value="ERS852478_03140"/>
    </dbReference>
    <dbReference type="GeneID" id="67482155"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="639"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="110"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="574"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO54549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX62928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="677" mass="75945" checksum="DE76FE0289CC3FFB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GBK9</accession>
    <name>A0A174GBK9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease accessory protein UreE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">ureE</name>
        <name evidence="7" type="ORF">ERS852478_03287</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UreE family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO59291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380160.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59291">
        <property type="protein sequence ID" value="CUO59291"/>
        <property type="gene ID" value="ERS852478_03287"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00822">
        <property type="entry name" value="UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012406">
        <property type="entry name" value="UreE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007864">
        <property type="entry name" value="UreE_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004029">
        <property type="entry name" value="UreE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036118">
        <property type="entry name" value="UreE_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05194">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02814">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036402">
        <property type="entry name" value="Ureas_acces_UreE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00988">
        <property type="entry name" value="UreE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69287">
        <property type="entry name" value="SSF69287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0533">Nickel</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UreE_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO59291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="158" mass="18172" checksum="CF2236DF2B8B9F49" modified="2016-09-07" version="1">MLCEQVLGKLHDFDTTGKTIEYVDIEWHEAFKKIHKKTTDKGTEVGIRMDDSILARGLYQDDVIYADNEKLVVVNTPPCEVIRVSLTPGHEKMSAKVCYEIGNRHAPLFWGENDTFITIYNEPMLVMLQKIHGVQAEKEVLKLDFDKRISASIHNHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GJF2</accession>
    <name>A0A174GJF2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ureidoglycolate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO62131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052434.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000121.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62131">
        <property type="protein sequence ID" value="CUO62131"/>
        <property type="gene ID" value="ERS852478_03369"/>
    </dbReference>
    <dbReference type="GeneID" id="66494070"/>
    <dbReference type="eggNOG" id="COG3194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032358">
        <property type="entry name" value="DUF4867"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16161">
        <property type="entry name" value="DUF4867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO62131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="162" mass="17981" checksum="BD2977E050056657" modified="2016-09-07" version="1">MRELKATKINAADFAPFGTFFSMTEPEGYPLQGEIHKFYPDRISGTCMGSIGFSPIAVHKDERIVKAAEYHTTTWEGIVALDDDMIIHVAPASAGAPVPELTRAFIVPKGTMVKINAAIWHLCPLPLNNEVLHAMIILPECTYANDCTVVDFEEKDWFKITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GPS2</accession>
    <name>A0A174GPS2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="4">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">dacB_7</name>
        <name evidence="18" type="ORF">ERS852478_03401</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63267">
        <property type="protein sequence ID" value="CUO63267"/>
        <property type="gene ID" value="ERS852478_03401"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015956">
        <property type="entry name" value="Peniciliin-bd_prot_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012907">
        <property type="entry name" value="Peptidase_S11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037167">
        <property type="entry name" value="Peptidase_S11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07943">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69189">
        <property type="entry name" value="SSF69189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 18" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022712" description="Serine-type D-Ala-D-Ala carboxypeptidase" evidence="15">
        <location>
            <begin position="28"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="16">
        <location>
            <begin position="42"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="PBP5_C" evidence="17">
        <location>
            <begin position="342"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="12">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CUO63267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="412" mass="46310" checksum="1252FA6C37D64C82" modified="2016-09-07" version="1">MRMKHIAAVIVVTAVLLFTQTYTSARGAEYKIPQTVDMTPVAEEPAELYALSAVLMDGESGRVLYEKDGERPLANASTTKVLTCIVALENSPGDDYVLVSQNAASQPEVKLGLQKGEQYYLEDLLYSLMLKSHNDTAVAIAEHCGGSVEGFARMLNRKAKQIGCKNTYFITPNGLDAEDENGKHHTTAKDLALIMRYAVKNETFLHIAQTRDYTFSEITGKRTFSVHNANAFLDMRDGVLAGKTGYTSQAGYCYVCAWEKEGKTFIVSLLGCGWPNHKTYKWSDTEKLLDFGDYNYEYETYWKEPQTGKILVTDGVEDGQDIGTKIYLRGKCSVTAYDREKEVLLKKGETVTCKIEIPQKVSAPVLKGEKLGRIAYYLDGKLIDFYPVYAEKSVEKISFKWYTEKVFHDFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GRI3</accession>
    <name>A0A174GRI3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacillibactin transport regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional activator Btr</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">btr_5</name>
        <name evidence="6" type="synonym">btr_2</name>
        <name evidence="6" type="ORF">BWLFYP14_02331</name>
        <name evidence="3" type="ORF">ERS852478_03462</name>
        <name evidence="5" type="ORF">GT712_16620</name>
        <name evidence="4" type="ORF">GT728_16145</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">BIOML-A1</strain>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708213.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65184">
        <property type="protein sequence ID" value="CUO65184"/>
        <property type="gene ID" value="ERS852478_03462"/>
    </dbReference>
    <dbReference type="GeneID" id="66493945"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="151"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO65184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="255" mass="29447" checksum="AD69200694A3345F" modified="2016-09-07" version="1">MQEKSKEYNEKEQQVAENRSRNTLFERRENLQKHESYASERRQYDAIRNGQTDRIQSVFQITPDGTPGILSRNELRNSKNMFIAGITLFTRAAIEGGVPEETAYALSDGYIQTVEECTSKSSIEKLSQKAALRFAQEVQKSGMRHYSREIEAAVKYIHLHLHVPVTLEETAEAAGISASYLSRLFKKETGMLFVDYIQKERIEAACNMLTYSDYTAAQISEYLCFSTQSYFIKIFRKYTGTTPAKYKKYKVQDWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GRT0</accession>
    <name>A0A174GRT0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted AAA-ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64671">
        <property type="protein sequence ID" value="CUO64671"/>
        <property type="gene ID" value="ERS852478_03452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018631">
        <property type="entry name" value="AAA-ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012547">
        <property type="entry name" value="PDDEXK_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09820">
        <property type="entry name" value="AAA-ATPase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08011">
        <property type="entry name" value="PDDEXK_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA-ATPase_like" evidence="1">
        <location>
            <begin position="28"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO64671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="535" mass="61694" checksum="318A92E7C57FA50D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GSI2</accession>
    <name>A0A174GSI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sporulation initiation factor Spo0A</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Sporulation initiation factor Spo0A C terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_02346</name>
        <name evidence="3" type="ORF">ERS852478_03476</name>
        <name evidence="5" type="ORF">GT712_16545</name>
        <name evidence="4" type="ORF">GT728_16070</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">BIOML-A1</strain>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708193.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65534">
        <property type="protein sequence ID" value="CUO65534"/>
        <property type="gene ID" value="ERS852478_03476"/>
    </dbReference>
    <dbReference type="GeneID" id="66493930"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042173">
        <property type="term" value="P:regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014879">
        <property type="entry name" value="Spo0A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08769">
        <property type="entry name" value="Spo0A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spo0A_C" evidence="2">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO65534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="70" mass="8195" checksum="BC13B59C59E66625" modified="2016-09-07" version="1">MREKTIYEKIAEKYNTTPEEVRREMQIAIDAGFDNPDPAVQEEWKKMTLKGDRPIPEEVINYAVKKLKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GU40</accession>
    <name>A0A174GU40_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Als operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpiR</name>
        <name evidence="3" type="ORF">ERS852478_03493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060741.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPN010000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66212">
        <property type="protein sequence ID" value="CUO66212"/>
        <property type="gene ID" value="ERS852478_03493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="127"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO66212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="290" mass="32824" checksum="2DAF0446F4B162F0" modified="2016-09-07" version="1">MDTIQYPTLIKINEMYPQMTQSQQQLATYILENPSIVVNTSITDLMSHTNFRSEASVVKFCRLLGFDGFKSFKIKLTQEYLNRTFYHSQNDITLDDTPGDIKKKVFLGAINSLNKNSDTIIDECTEAQRLIISANRIIIIGHGASAAICQYAYFRFTELGLNCVYNLDAHMTAALLSHPKTNDLILCVSQSGETADIYKQIENAYRNRITTILITGNPNSSIAKISTVVLSTLSEEFNILTDALNSRISQFCLIDALFSMISIKDANRMIPRLQETRNTFKKYKIEQNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H354</accession>
    <name>A0A174H354_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">macB_9</name>
        <name evidence="5" type="ORF">ERS852478_03597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005362411.1">
        <property type="nucleotide sequence ID" value="NZ_WWVO01000091.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69283">
        <property type="protein sequence ID" value="CUO69283"/>
        <property type="gene ID" value="ERS852478_03597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO69283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="221" mass="24453" checksum="B6A774A80041000D" modified="2016-09-07" version="1">MSILQTIDLKKYYGTEPNITRALDGVNFSVEDGEFVAVVGTSGSGKSTLLHMMGGLDTPTSGNVIVRDKELSKMNDEQLTIFRRRNIGFIFQNYNLVPILNVYENIVLPVELDGDTVDQKFLDEIVHLLGLEDKLKNMPNNLSGGQQQRVAIARALITKPAIVLADEPTGNLDSKTSAEVLGLIKRTSAEFRQTVVMITHNDDIARLADRIVRIEDGKIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H4M3</accession>
    <name>A0A174H4M3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03613</name>
        <name evidence="3" type="ORF">ERS852523_01454</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO69823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP38846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055150663.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000077.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69823">
        <property type="protein sequence ID" value="CUO69823"/>
        <property type="gene ID" value="ERS852478_03613"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP38846">
        <property type="protein sequence ID" value="CUP38846"/>
        <property type="gene ID" value="ERS852523_01454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045515">
        <property type="entry name" value="DUF6440"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20037">
        <property type="entry name" value="DUF6440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6440" evidence="1">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP38846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="61" mass="6793" checksum="E0DD525FCDBED356" modified="2016-09-07" version="1">MAKKEERFEVIFRDGSSLKDEGIRQILVDKETGVNYLCWKSGYGAGITPLLDSEGTVVITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H5F5</accession>
    <name>A0A174H5F5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA strand transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mobA_5</name>
        <name evidence="5" type="ORF">ERS852478_03574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MobA/MobL family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201444.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68458">
        <property type="protein sequence ID" value="CUO68458"/>
        <property type="gene ID" value="ERS852478_03574"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005053">
        <property type="entry name" value="MobA_MobL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03389">
        <property type="entry name" value="MobA_MobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0184">Conjugation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MobA_MobL" evidence="4">
        <location>
            <begin position="17"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="318"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="464"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO68458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="591" mass="69544" checksum="9AAE26050E165F4B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H8L5</accession>
    <name>A0A174H8L5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor WhiG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201460.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69369">
        <property type="protein sequence ID" value="CUO69369"/>
        <property type="gene ID" value="ERS852478_03600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="80"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="143" mass="16660" checksum="368754431DAE7342" modified="2016-09-07" version="1">MEAIPRKYGEWSQFDRYCKLVLYHEAIDYLREMKCRRDREVSLDAVSPADWDKLSTVDRYSCDSFTFSSHGYDLHIDNELVAEAFASLPKDEQSILILRFVLDLTDEEIGRLMGMSRSAVQRHRTSTLKDLRIKLMAFMPEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HE94</accession>
    <name>A0A174HE94_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="9">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">macB_13</name>
        <name evidence="9" type="ORF">ERS852478_03731</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000045">
        <property type="protein sequence ID" value="CUO73174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73174">
        <property type="protein sequence ID" value="CUO73174"/>
        <property type="gene ID" value="ERS852478_03731"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="16"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="301"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO73174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="397" mass="42967" checksum="FE169F8491E1E9FF" modified="2016-09-07" version="1">MLKMILKDLRLSPLRSILTSVSMLVGIIAMLGSVLVGTLGREYLIFVNAQVYGWSPTYSFVITESDFHDRNKMEQLFQRFEAIDDVAAVTFSMGEDIRFAPMKDLTPIPPNDVYQNLMAFDLVCTTEAYSQVYNLPMTSGRWLEPSSEGGSLEVVINKEAKNYFNDSPYAAGNVKSTLSLTPFNIVGVVNDGRDFPTIYADSAAILNFAPAMWQVQNANVYWHPTTGLTIEQIHSALGDILTDTIGGYWESAGRSDIGDTYDSVLSILQLGLLVTSLLLLFVSVLGQINIGLSSLEQRTHELLIRRAIGASRTNIVALVLGSQLILSIFVCLAAILISLILVHCIGALLPVDSPVGTPSYPISVAVVAVAVSVLTALLGGLLPALKAAKLEPALALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HHP9</accession>
    <name>A0A174HHP9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000044">
        <property type="protein sequence ID" value="CUO72688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993809.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72688">
        <property type="protein sequence ID" value="CUO72688"/>
        <property type="gene ID" value="ERS852478_03715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="7"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO72688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="59" mass="6658" checksum="131B44CEE4285CD7" modified="2016-09-07" version="1">MSEAIGTREFAEKFGVTPATVSKWCREGKIPNCNQDGKESPWHIPKDAVPPVGYKRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HI88</accession>
    <name>A0A174HI88_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA polymerase IV</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dinB_2</name>
        <name evidence="4" type="ORF">ERS852478_03778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000049">
        <property type="protein sequence ID" value="CUO74622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201522.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000049.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74622">
        <property type="protein sequence ID" value="CUO74622"/>
        <property type="gene ID" value="ERS852478_03778"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="3">
        <location>
            <begin position="8"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO74622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="509" mass="58596" checksum="50EDC8FB7E3AC8C6" modified="2016-09-07" version="1">MTEKKRTYIAIDLKSFYASVECKERNRDPLATNLVVADKSRTEKTICLAVSPALKCYGIPGRARLFEVVQKVKEANSARRWKAPNRTFIGSSDDSTELNINSALEIDYIVAPPRMALYLEYSTRIYSIYLKYIAPEDIFPYSIDEVFMDVTDYLHTYNMTPRELAMTMIQDVLKTTGITATAGIGTNMYLCKIAMDIVAKHIKADKDGVRIAELDEMSYRRKLWSHRPLTDFWRVGKGYAKKLEEYGLYTMGDIARCSIGKANELYNEDLLYKLFGVNAELLIDHAWGYEPCTMEMVKAYKPETNSVCSGQVLHCPYDFEKAKLVVKEMTDQMVLDLVDKKLVTDQIVLTVGYDIENLNNADRKKQYHGEVTIDRYGRRIPKHAHGTTNLKRRTSSTKMIMDAVIKLYDRIVDRNMLIRRINITANRLVDESSVEREELYEQLDLFTDYEAQRKKQEEEEAALDREKRMQEAMLNIKKKFGKNAVLKGMNLQEGATARDRNEQIGGHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HMY9</accession>
    <name>A0A174HMY9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide pyruvyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000048">
        <property type="protein sequence ID" value="CUO74245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704449.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74245">
        <property type="protein sequence ID" value="CUO74245"/>
        <property type="gene ID" value="ERS852478_03767"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="13"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO74245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="386" mass="45212" checksum="0AFCF93686508B17" modified="2016-09-07" version="1">MKIGICTCYDNHNYGSMLQAYATYVKFVELGYDCEFLCYRKKLNTIQKIKWLPRLLNKYLMKEKFRLIEKKIQLKKHPDIKMKDAIRQRAFDRFLENFLKDKVSAPYIGFEALRAGSKNYDVVVAGGDQLWIPAGLPTNFFNLMFADEKVKRVSYSTSFGVTEVPFYQKRRTIEYLNRIEMLGVREKSGAELIERLTGRKAVVVLDPTLLLNKEEWAQAIPVKPVLENDYIFCYFLGANSEHRKVAEELSRKTGIPLYDMPHIDEFVPYDLQFNAEHLYDIDSEQFVNLIRYAKYICTDSFHCTVFSILHHKQFLAFDRYSDPLMMSRNSRIANLCDITGLSSRRYTGDVLEQMKKPIDYDRVDERLEKEKAISVAYIREALGKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JBS7</accession>
    <name>A0A174JBS7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arylesterase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">GDSL-like Lipase/Acylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_02332</name>
        <name evidence="2" type="ORF">ERS852478_03463</name>
        <name evidence="3" type="ORF">ERS852523_00010</name>
        <name evidence="5" type="ORF">GT712_16615</name>
        <name evidence="4" type="ORF">GT728_16140</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO94569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708211.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000048.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000161_gene1326"/>
    <dbReference type="EnsemblBacteria" id="CUO65212">
        <property type="protein sequence ID" value="CUO65212"/>
        <property type="gene ID" value="ERS852478_03463"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94569">
        <property type="protein sequence ID" value="CUO94569"/>
        <property type="gene ID" value="ERS852523_00010"/>
    </dbReference>
    <dbReference type="GeneID" id="66493944"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="6"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO65212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO94569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="206" mass="23438" checksum="2EED9262CC146749" modified="2016-09-07" version="1">MKQILCFGDSNTYGLIPGTTNQRYGWGTRWTSILDDKVRTKGYRVIEEGLCGRTTVFDDPFRTERRGTEMLPAILESHRPVDTIVLMLGTNDCKSVYSATPEVIGQGIEQLLDQINTVNPDAKILLVSPIYLGERIWEEDFDPEFDKNSIEVSWNLPRVYEKIARRRNISYLPASEFARPGEADQEHLDELGHSRLADAIYEKLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JEM1</accession>
    <name>A0A174JEM1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">5-oxoprolinase subunit PxpB</fullName>
            <ecNumber evidence="7">3.5.2.9</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Kinase A inhibitor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Sporulation inhibitor kipI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">kipI</name>
        <name evidence="7" type="synonym">pxpB</name>
        <name evidence="8" type="ORF">BWLFYP14_00420</name>
        <name evidence="5" type="ORF">ERS852478_02000</name>
        <name evidence="6" type="ORF">ERS852523_00083</name>
        <name evidence="7" type="ORF">GT728_08930</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
            <strain evidence="6 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.2.9" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO96347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993687.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2248"/>
    <dbReference type="EnsemblBacteria" id="CUO15752">
        <property type="protein sequence ID" value="CUO15752"/>
        <property type="gene ID" value="ERS852478_02000"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96347">
        <property type="protein sequence ID" value="CUO96347"/>
        <property type="gene ID" value="ERS852523_00083"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010016">
        <property type="entry name" value="KipI_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34698">
        <property type="entry name" value="PTHR34698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00370">
        <property type="entry name" value="TIGR00370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS1" evidence="4">
        <location>
            <begin position="4"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO15752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO96347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX62322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="241" mass="27096" checksum="6DB83032D2F44392" modified="2016-09-07" version="1">MPDIRILTEGDSSVLVEFGKEISPEINRKITATVQLMKEQHIEGVVDMIPAFCSLLVNYDPRVISYDDLKKRLEILLKMEVTAGEGCRKVYEIPVCYGGEYGPDIENIAEHAGLSVEEVIKIHSSRDYLIYMLGFLPGFCYLGGLDERIHTPRLANPRIKINAGSVGIGGSQTGIYPLDSPGGWQLMGMTPVKTYDPDREIPILVEAGDYIRFVPIDEDEYKRIRELVERGEYQCTVHEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KEH4</accession>
    <name>A0A174KEH4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">16S/23S rRNA (Cytidine-2'-O)-methyltransferase TlyA</fullName>
            <ecNumber evidence="4">2.1.1.226</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="5">TlyA family rRNA (Cytidine-2'-O)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tlyA</name>
        <name evidence="7" type="ORF">BWLFYP14_03067</name>
        <name evidence="3" type="ORF">ERS852478_01167</name>
        <name evidence="4" type="ORF">ERS852523_00488</name>
        <name evidence="6" type="ORF">GT712_03600</name>
        <name evidence="5" type="ORF">GT728_00355</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.226" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP08005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704090.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2135"/>
    <dbReference type="EnsemblBacteria" id="CUN82476">
        <property type="protein sequence ID" value="CUN82476"/>
        <property type="gene ID" value="ERS852478_01167"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08005">
        <property type="protein sequence ID" value="CUP08005"/>
        <property type="gene ID" value="ERS852523_00488"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN82476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP08005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL31684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS88197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="269" mass="29784" checksum="330986B3979436B9" modified="2016-09-07" version="1">MKKRLDMLMMERALAPSREKAKAFIMAGDVYVDGQKEDKAGTMFPETVKIEVRGNTLPYVSRGGLKLEKAMKNFDVTLDSKVCMDVGASTGGFTDCMLQNGAVKVYSIDVGYGQLDWKLRNDPRVVCMEKTNIRYVVPEDLGEPADFSSIDVSFISLTKVLLPVRNLLTDEGEIVCLIKPQFEAGREKVGKKGVVRDPAVHQEVIEKVRDYAMSIFMEPCHLSFSPIKGPEGNIEYLLHLKKHPEGTGVTDSLKVSVEAVVAEAHGQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KEP0</accession>
    <name>A0A174KEP0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Stage III sporulation protein AC/AD protein family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Stage III sporulation protein AD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_03079</name>
        <name evidence="2" type="ORF">ERS852478_01155</name>
        <name evidence="3" type="ORF">ERS852523_00476</name>
        <name evidence="5" type="ORF">GT712_03540</name>
        <name evidence="4" type="ORF">GT728_00680</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP07709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994071.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2147"/>
    <dbReference type="EnsemblBacteria" id="CUN82058">
        <property type="protein sequence ID" value="CUN82058"/>
        <property type="gene ID" value="ERS852478_01155"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07709">
        <property type="protein sequence ID" value="CUP07709"/>
        <property type="gene ID" value="ERS852523_00476"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SJW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025664">
        <property type="entry name" value="Spore_III_AC/AD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06686">
        <property type="entry name" value="SpoIIIAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN82058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP07709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL31748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="128" mass="14110" checksum="11E4EE77C59D0C12" modified="2016-09-07" version="1">MDIVKVSIMGICGMMLGFILKETRPEFAALVTMMTGFLILGLAAGKVSYLFETMNRLRESFPIDSSYLTVLVKIIGITYIGQFSSAICKDAGYQMIGTQIDLFCKLSVMVLSMPVLLAILDTISEFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MFL9</accession>
    <name>A0A174MFL9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rpsS</name>
        <name evidence="12" type="ORF">BWLFYP14_00259</name>
        <name evidence="8" type="ORF">ERS852478_01661</name>
        <name evidence="9" type="ORF">ERS852523_01291</name>
        <name evidence="11" type="ORF">GT712_08970</name>
        <name evidence="10" type="ORF">GT728_04710</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707255.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2980"/>
    <dbReference type="EnsemblBacteria" id="CUO02724">
        <property type="protein sequence ID" value="CUO02724"/>
        <property type="gene ID" value="ERS852478_01661"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33557">
        <property type="protein sequence ID" value="CUP33557"/>
        <property type="gene ID" value="ERS852523_01291"/>
    </dbReference>
    <dbReference type="GeneID" id="61848975"/>
    <dbReference type="GeneID" id="66496124"/>
    <dbReference type="eggNOG" id="COG0185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO02724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP33557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL32520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS89199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX67418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="93" mass="10322" checksum="02B709F4C7355A6D" modified="2016-09-07" version="1">MSRSLKKGPFADASLLKKVDALNAANDKSVIKTWSRRSTIFPSFVGHTIAVHDGRKHVPVYVTEDMVGHKLGEFVATRTYRGHGKDEKKSGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MHG9</accession>
    <name>A0A174MHG9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rplW</name>
        <name evidence="10" type="ORF">BWLFYP14_00257</name>
        <name evidence="6" type="ORF">ERS852478_01659</name>
        <name evidence="7" type="ORF">ERS852523_01293</name>
        <name evidence="9" type="ORF">GT712_08980</name>
        <name evidence="8" type="ORF">GT728_04700</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707251.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2982"/>
    <dbReference type="EnsemblBacteria" id="CUO02655">
        <property type="protein sequence ID" value="CUO02655"/>
        <property type="gene ID" value="ERS852478_01659"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33630">
        <property type="protein sequence ID" value="CUP33630"/>
        <property type="gene ID" value="ERS852523_01293"/>
    </dbReference>
    <dbReference type="GeneID" id="66496122"/>
    <dbReference type="eggNOG" id="COG0089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO02655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP33630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL32518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX67416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="99" mass="11177" checksum="3A2CE8F8EFC226A9" modified="2016-09-07" version="1">MADIKYYDVIKKPVITEKSMNAMAEKKYTFLVHPEANKSQIKEAVEKMFEGTKVKSVNTMNMDGKKKRRGMTVGTTAKTKKAIVALTEDSKDIEIFEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174Q9N1</accession>
    <name>A0A174Q9N1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycolate phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gph</name>
        <name evidence="3" type="synonym">gph_1</name>
        <name evidence="3" type="ORF">BWLFYP14_01499</name>
        <name evidence="1" type="ORF">ERS852478_02270</name>
        <name evidence="2" type="ORF">ERS852523_02409</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.18" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000025">
        <property type="protein sequence ID" value="CUP67425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705515.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000042_gene3010"/>
    <dbReference type="EnsemblBacteria" id="CUO25285">
        <property type="protein sequence ID" value="CUO25285"/>
        <property type="gene ID" value="ERS852478_02270"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP67425">
        <property type="protein sequence ID" value="CUP67425"/>
        <property type="gene ID" value="ERS852523_02409"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO25285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP67425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX64646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="221" mass="24583" checksum="383ABB2BC5B46203" modified="2016-09-07" version="1">MIKACIFDLDGTLADTLDSMAYVTNIIMEKFGLKTLPVDNFRYYSGEGANMLIRRALKDAGDPELAHYDEGQKLYREMFEADPMYKVVPYKGMPETLKKLKEHGMKLAVCSNKPHPAAVKVIAQLFDGEFDMVVGQSEAIRRKPAPDGPLMVAEKFGVKPEECMYVGDTSTDMKTGKAAGMYTVGALWGFRDRKELNENGADLVAEKPTDLVKICEEHGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QC57</accession>
    <name>A0A174QC57_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anaerobic ribonucleoside-triphosphate reductase activating protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Molybdenum cofactor biosynthesis protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BWLFYP14_01243</name>
        <name evidence="6" type="ORF">ERS852478_00861</name>
        <name evidence="7" type="ORF">ERS852523_02484</name>
        <name evidence="9" type="ORF">GT712_07995</name>
        <name evidence="8" type="ORF">GT728_01040</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
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                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
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                <person name="Smith M."/>
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                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
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                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
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                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
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                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
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                <person name="Raman A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
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    <sequence length="57" mass="6707" checksum="1963744776B29771" modified="2016-09-07" version="1">MIPKDPMILLSYVNTQLRDYYDSLEALCTCRGLKKDELVAKMHSIDYEYDEATNQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174UTI2</accession>
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    <reference evidence="7 13 14" key="2">
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                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000004">
        <property type="protein sequence ID" value="VUX62621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703710.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000029_gene631"/>
    <dbReference type="EnsemblBacteria" id="CUO33491">
        <property type="protein sequence ID" value="CUO33491"/>
        <property type="gene ID" value="ERS852478_02510"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ22259">
        <property type="protein sequence ID" value="CUQ22259"/>
        <property type="gene ID" value="ERS852523_04437"/>
    </dbReference>
    <dbReference type="GeneID" id="66495261"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO33491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUQ22259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL34148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS87954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX62621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="223" mass="24750" checksum="AE82141C6212800E" modified="2016-09-07" version="1">MILELKGIYKEYQQGKMKVPVLKDVNFSMEEGEYVAIMGPSGSGKTTLMNIIGCLDKQTEGTFFLDGVDIKACSENEMSDIRLNKIGFVFQSFHLLPKQSALANVEMPLNYARVPKKERRERALKALDRVGLADRVDFKPNQLSGGQMQRVAIARAIVNNPKLLLADEPTGALDSKSGAQVMELFQRLNDEGVSVLMITHDADIAAHAKRVVTIKDGILQEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WVQ0</accession>
    <name>A0A173WVQ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Enolase</fullName>
            <ecNumber evidence="9">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">eno_1</name>
        <name evidence="9" type="synonym">eno</name>
        <name evidence="14" type="ORF">ERS852478_00082</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
        <text evidence="9">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43180">
        <property type="protein sequence ID" value="CUN43180"/>
        <property type="gene ID" value="ERS852478_00082"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="13">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="12">
        <location>
            <begin position="140"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 11">
        <location>
            <begin position="369"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9 10">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="9">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 11">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN43180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="433" mass="46428" checksum="F9DBF5B2AF4015B8" modified="2016-09-07" version="1">MYLEIEKVIGREILDSRGNPTVEAEVYLMDGTVARGTAPSGASTGEFEALELRDGDKARYLGKGVQKAVENINTTINEAIEGLDASDIYAVDAAMIAADGTKDKSKLGANAILAVSIACCRAAAASLEIPLYRFLGGVSGNRLPVPMMNIVNGGCHALSSGLDVQEFMIMPVGAPSFKECLRWCAEVFHALASILKERGLATSVGDEGGFAPALKSDEEAIETILEAVKKAGYESGKDFRIAMDAASSEWKSEKGKGYYKLPKAGTEYTSEELIEHWAKLCEKYPIISIEDGLDEEDWEGWQKLTARLGDKVQLVGDDLFVTNTERLAKGISLGAGNAILIKLNQIGSVSETLEAIKMAHKAGYTAISSHRSGETADTTIADLAVALNTCQIKTGAPSRSERVAKYNQLLRIEEELGASAVYPGMKAFNVKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WX78</accession>
    <name>A0A173WX78_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial Ig-like domain (Group 2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
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            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NZ_WWVD01000039.1"/>
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        <property type="gene ID" value="ERS852478_00263"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN49227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="76" mass="8632" checksum="670E0836EFDBC86A" modified="2016-09-07" version="1">MLRKLNCFLNIVIGSSIGVFIGFGIYKFWHFKTYPNLYAIQSAPWYTELLLDGALVAVVVVVCIILKLIIRKNSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XEU6</accession>
    <name>A0A173XEU6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-allose transport system permease protein AlsC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">alsC</name>
        <name evidence="7" type="ORF">ERS852478_00299</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577579.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50301">
        <property type="protein sequence ID" value="CUN50301"/>
        <property type="gene ID" value="ERS852478_00299"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN50301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="332" mass="35393" checksum="481142F3D388BBE1" modified="2016-09-07" version="1">MAGKSGRSINNVPESPIKHMIFSWEGILVILFIMVNIFCKGFSEYYNLENLLRQMPVYLAEVFLMIPMAYILVLGEIDISVGATVCLSATLSCIMCNTGAPFIVVILTALIVGTVCGAVNGFILTQFEELPPMIVTLATQIIFRGIAEIVLGSGGSISASNTDGFRLIGGKVGKVPYILFLVLILAVIFAVILGKSTFGRRVYAIGTNRLTAYYSGIHVKKIRFIIYTVMGTFCGLCALFLVASSYGANTTTGNGFEMDAIAMAVFGGISSTGGKGNLAGGLISAFIIVCLRVGLGQRNVHAQVILLIIGVLLICAVALPNIIENIKRAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XIB5</accession>
    <name>A0A173XIB5_9FIRM</name>
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        <submittedName>
            <fullName evidence="7">Glutathione transport system permease protein gsiD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gsiD_1</name>
        <name evidence="7" type="ORF">ERS852478_00340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199576.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51562">
        <property type="protein sequence ID" value="CUN51562"/>
        <property type="gene ID" value="ERS852478_00340"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="89"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN51562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="288" mass="30951" checksum="BD7A05FFC67B3C08" modified="2016-09-07" version="1">MSEKQNKNVTVRVQKIKKNHIKQKLVFFLILAIGLVILAVFSEHLCPYDPYAQDLASALQPPSLQHPMGTDTYGRDMLSRVISGARASIFSTFILVAVISVLGTAVGVCCGYFGGAADAVMMRISDVCLAFPGLVFAMAIAAILGGGIQNAVIALAVVSWPKYSRIARGQTLALKEEPYIHAAILAGDSSGQIMLRHILPNMLGPVLITAMLDIGTMMMELAGLSFLGLGAQIPMAEWGSMMSGGRSMIQTYPWVVLSPGIAIFISVAIFNLLGDTFRDYLDPKNSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XM28</accession>
    <name>A0A173XM28_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_02003</name>
        <name evidence="1" type="ORF">ERS852478_00384</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579122.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52982">
        <property type="protein sequence ID" value="CUN52982"/>
        <property type="gene ID" value="ERS852478_00384"/>
    </dbReference>
    <dbReference type="GeneID" id="66496014"/>
    <dbReference type="eggNOG" id="ENOG503400U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN52982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX65412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="73" mass="8222" checksum="C3A882593FE66E32" modified="2016-09-07" version="1">MHEYEIFIEDINPCGGEQYSKKTLIEAEAASPEAYVKENGRFPILESTRNESGDVVIVTGDNQGSFVRYTFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XTX8</accession>
    <name>A0A173XTX8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yycG</name>
        <name evidence="8" type="ORF">ERS852478_00415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199607.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53818">
        <property type="protein sequence ID" value="CUN53818"/>
        <property type="gene ID" value="ERS852478_00415"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="211"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN53818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="425" mass="47811" checksum="79046FCCEC90FCBE" modified="2016-09-07" version="1">MFRRLHIQMTFFSALIIGIVIFIMTTACNFIAENSTRQNAWNTFQNNAISCISHLETQSIISSDWILQAEKNYDISMDIRDNGNSLYLKKLQTDSLDETIFRKAEEISAASYALDLSNPGAVSKLTKRSFFQMKDFYVSTALIPKSHGTVSMIILYSLDSVKHRILLQRLAFSGAAFLAILALSICSWFFTGRMITPLEKSRQEQTEFIAAASHELRSPLAVILSGISAMKKADPKEQEHFLSVIEKEGTRMSLLINDMLSLSNADNHSWKMHPVSCELDTLLLDTYEKYEPLMQDHHMKFFIELPEEEIPPCPCDPERISQVLGILLDNAISYVPENGKIILSLSQTKTHFLIRVKDNGPGIPDSAKTSVFRRFYRADSARNNRQHFGLGLCIAYEIISLHKGTISVLDTPGGGSTFQISLPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y1C5</accession>
    <name>A0A173Y1C5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199677.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57360">
        <property type="protein sequence ID" value="CUN57360"/>
        <property type="gene ID" value="ERS852478_00497"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN57360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="172" mass="19671" checksum="669C94E8B3B081FA" modified="2016-09-07" version="1">MSTNNMDRFEFRCIRPEETQQAIEIEQICFPPNEACSPKSLTERIKATAETFLVAEDKETGKLAAFLNGVPTDEDAFRDEFFTDISLINPEGKNIMLLGLDVRPEYRMQGLGRELVSRYSQREAQKGRKKLFLTCLDEKVKMYEKFGFTDLGQANSTWGGEAWHAMSIEIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y288</accession>
    <name>A0A173Y288_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoesterase</fullName>
            <ecNumber evidence="4">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yfcE</name>
        <name evidence="6" type="ORF">ERS852478_00524</name>
        <name evidence="7" type="ORF">GT712_12385</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000024">
        <property type="protein sequence ID" value="MZS89843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053062.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58271">
        <property type="protein sequence ID" value="CUN58271"/>
        <property type="gene ID" value="ERS852478_00524"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="5">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN58271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS89843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="180" mass="20500" checksum="83CE20DD0FE32B34" modified="2016-09-07" version="1">MKYMFASDVHGSAYYCRKMLDAYKEEKAERLVLLGDLLYHGPRNDLPREYAPKQVISMLNDMKKEIYAVRGNCEAEVDQMVLQFPVMADYCILNLDGRTFYATHGHIYNENNLPPIQEGDILIHGHTHVLKAEQKEGYVLLNPGSVSIPKEGNPPTYAIFEDGVFTIKDFEGNIVKSIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y2I4</accession>
    <name>A0A173Y2I4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxynorspermidine/carboxyspermidine decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lysA_1</name>
        <name evidence="12" type="ORF">ERS852478_00513</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>carboxynorspermidine + H(+) = CO2 + norspermidine</text>
            <dbReference type="Rhea" id="RHEA:34099"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57920"/>
            <dbReference type="ChEBI" id="CHEBI:65070"/>
            <dbReference type="EC" id="4.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>carboxyspermidine + H(+) = CO2 + spermidine</text>
            <dbReference type="Rhea" id="RHEA:34095"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:65072"/>
            <dbReference type="EC" id="4.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.96" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199689.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57873">
        <property type="protein sequence ID" value="CUN57873"/>
        <property type="gene ID" value="ERS852478_00513"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045312">
        <property type="term" value="P:nor-spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06829">
        <property type="entry name" value="PLPDE_III_CANSDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005730">
        <property type="entry name" value="Nsp_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43727:SF1">
        <property type="entry name" value="PTHR43727:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038941">
        <property type="entry name" value="NspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01047">
        <property type="entry name" value="nspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="11">
        <location>
            <begin position="11"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038941-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN57873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="373" mass="42212" checksum="81D1F3CACF01E20E" modified="2016-09-07" version="1">MKIDQLQTPCYVIDEKKMRENLEILKKVQEDTGCKILLAQKAFSGFALYPMIGKYLAGTTASGLFEARLGYEEMGKENHVFSPAYRTEDIEELDRICDHIIFNSTAQLKKFKEVCTGASLGLRINPECSTQGDHAIYDPCAPGSRLGVTRENFDGECLKWIDGLHFHTLCEQNADDLEKTLQAVEEKFGEFLSEVSWLNMGGGHHITREDYDVKLLEKCIQHMKETYDLDIYLEPGEAVALNAGYLVTEVMDIVENEIRTLILDASAACHMPDVLEMPYRPPLKDSGEAGEKAYTYRLSSCTCLAGDVIGDYSFDREIRIGDKLYFMDMAIYSMVKNNTFNGMPLPDIAVMHEDGECEVIRHFGYEDFKSRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y802</accession>
    <name>A0A173Y802_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Penicillinase repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_03313</name>
        <name evidence="2" type="ORF">ERS852478_00556</name>
        <name evidence="3" type="ORF">ERS852523_03061</name>
        <name evidence="5" type="ORF">GT712_13380</name>
        <name evidence="4" type="ORF">GT728_05095</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000038">
        <property type="protein sequence ID" value="CUP85931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000009">
        <property type="protein sequence ID" value="MZL32595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000027">
        <property type="protein sequence ID" value="MZS90038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX67036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993513.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000024_gene287"/>
    <dbReference type="EnsemblBacteria" id="CUN59125">
        <property type="protein sequence ID" value="CUN59125"/>
        <property type="gene ID" value="ERS852478_00556"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP85931">
        <property type="protein sequence ID" value="CUP85931"/>
        <property type="gene ID" value="ERS852523_03061"/>
    </dbReference>
    <dbReference type="GeneID" id="66493133"/>
    <dbReference type="eggNOG" id="ENOG503366W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN59125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP85931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX67036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="124" mass="14296" checksum="460BACAE7B2D5BCA" modified="2016-09-07" version="1">MDILKGKRYDIMNVLWEEGRPLSAFEINDIAPELKMPTVRRCLELLLKENLIQVAGTSMNGKVYARNYTPLLSREDYLKGNAKSRKINPVEMMNALLESDGITVEELEKLQELIDKKRAELESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YG05</accession>
    <name>A0A173YG05_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zinc_ribbon_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199730.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61935">
        <property type="protein sequence ID" value="CUN61935"/>
        <property type="gene ID" value="ERS852478_00637"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033A9E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zinc_ribbon_2" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN61935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="195" mass="21783" checksum="FDE0413B03751D34" modified="2016-09-07" version="1">MGTDFFDGLVKTFSKTTKELGKTTRELGARAEQTIEAQKIRSKITGEERIIEKIKVDIGDIVYRRHSQGDGIDSELSALCQEIDQHYLKIREYKDNAANLKGEKICPSCEREVDINVSFCPYCGTPCPTPEPAKNVENDIVSSDEDEDGSNGPEETPAEELQPEEPETEKAAETETAQEQPVEETPVEKEAMEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YNY3</accession>
    <name>A0A173YNY3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">ftsZ</name>
        <name evidence="11" type="ORF">BWLFYP14_01807</name>
        <name evidence="9" type="ORF">ERS852478_00701</name>
        <name evidence="10" type="ORF">ERS852523_00643</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
            <strain evidence="10 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP12884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000016_gene3646"/>
    <dbReference type="EnsemblBacteria" id="CUN65057">
        <property type="protein sequence ID" value="CUN65057"/>
        <property type="gene ID" value="ERS852478_00701"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12884">
        <property type="protein sequence ID" value="CUP12884"/>
        <property type="gene ID" value="ERS852523_00643"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="14"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="208"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="318"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="22"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN65057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP12884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX65040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="396" mass="41364" checksum="170965A4BF6B82CE" modified="2016-09-07" version="1">MLEIMSNEAESSAKIIVIGVGGAGNNAVNRMVEEAIGGVEFVGVNTDKQALTLCKAPTVLQIGEKITKGLGAGAQPEVGQKAAEESIEEVKQLMEGADMVFVTCGMGGGTGTGAAPVIAAAAKEMGILTVGVVTKPFRFEARTRMNNALAGIENLKKAVDTLIVIPNDKLLEVVDRRTTMPEALKKADEVLQQAVQGITDLINLPALINLDFADVQTVMTDKGIAHIGIGEARGDDKAMEAVQQAVSSPLLETTIKGATHVIINISGDISLMDANDAASYVQELTGEEANIIFGAMYDDTVADYCRITVIATGLNDDNLQQTPFGKRSTASSFGARRPSSTATTGTATAGTAAGSGMNMPSFSLPTMNATPFGASKTPSSTVQKKDIQIPDFLRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YSI6</accession>
    <name>A0A173YSI6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">prkC_1</name>
        <name evidence="11" type="ORF">ERS852478_00730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199783.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66005">
        <property type="protein sequence ID" value="CUN66005"/>
        <property type="gene ID" value="ERS852478_00730"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="12"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="392"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="464"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="10">
        <location>
            <begin position="538"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="378"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN66005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="727" mass="78421" checksum="8F590882FCE967ED" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YZH5</accession>
    <name>A0A173YZH5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Putative ABC transporter ATP-binding protein YxlF</fullName>
            <ecNumber evidence="7">3.6.3.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Uncharacterized ABC transporter ATP-binding protein YbhF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybhF_1</name>
        <name evidence="7" type="synonym">yxlF_4</name>
        <name evidence="7" type="ORF">BWLFYP14_01722</name>
        <name evidence="5" type="ORF">ERS852478_00799</name>
        <name evidence="6" type="ORF">GT712_02770</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381160.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68626">
        <property type="protein sequence ID" value="CUN68626"/>
        <property type="gene ID" value="ERS852478_00799"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN68626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS88033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX64869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="285" mass="32466" checksum="92A893ADBC79A4C3" modified="2016-09-07" version="1">MEQNSIVVKNVTKKFDDFMLDHISFTVPTGRIVGFIGENGAGKSTTINLILDQLKLDAGEIRILGKQNHSYLHKENIGVVFDECKFHSVLNAKDIAQILSGSYKTWDMNLFEEYMKRLDVPLNKSIGQLSKGMKMKLSIICALSHRPQILILDEATTGLDPVVRDEILDIFLEFIQDEEHSILFSTHITSDIQKVADYVILIHNGKIIFEEKKDDLIYNYGIIRCKKSEFNTVSPDDYVCCRETNLSVECLIHDKVAAKKRYKNLIIDNASIEDIMLFYIKGGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z121</accession>
    <name>A0A173Z121_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Na(+)/drug antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">norM_2</name>
        <name evidence="2" type="ORF">ERS852478_00824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199814.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69413">
        <property type="protein sequence ID" value="CUN69413"/>
        <property type="gene ID" value="ERS852478_00824"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5034BMY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN69413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="444" mass="48344" checksum="CFD10451F4277C28" modified="2016-09-07" version="1">MDERKRSLRKEIVRLALPIALQQFMTALVGACDAIMLGKLSQDAMSAVSLATQVTFVFNLFMFAFMAGENMFVAQYYGKGDYTGISQVFSLVTKICGCIAVVFLAGTLFFPEQLMRILTNEETLIVLGSEYLRVIGISYVFSGIAQIFLAIMKNCGAVNMSTLINGVMVILNIALNAVFIFGLSGFPKMGIKGAALATVLATVVQFLWSVGYVLCRIRAVKFSLRSCEKKLFGRFWQKTVPLLINNLAWGIGFSMYSVIMGHLGTDAVAANGIANISKNLVVCFCLGLGNAGSIIVGNRLGADRLQEAKEVGETLTKTAIIAGIVSGLVLIALSPFITKMVDLTPTARGYLQKMLLISSYYIAGKSVNCMTIGGIFAAGGDSKFGMMCDSVTLWCIIVPLGCICAFILKLPVMVVYFVLNLDEIIKLPVVYKHYKKYKWIKNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZAH2</accession>
    <name>A0A173ZAH2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylglyoxal synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72195">
        <property type="protein sequence ID" value="CUN72195"/>
        <property type="gene ID" value="ERS852478_00887"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045962">
        <property type="entry name" value="DUF6382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19909">
        <property type="entry name" value="DUF6382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="422"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN72195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="497" mass="56694" checksum="ECE7786E0EB732BE" modified="2016-09-07" version="1">MRTEYKRDMNHNYLIVYGENEINTDSYQVRMLAGNVIPSLLKCRIQGMDGRFLIYFDITSKQAVNVLYEEKKMGVEDLRLIFGGFVKAMEDAAEYLINPGQFIMLPEYIYTDIEKRQIYFCMMPGYEKDIKEQFQLLTEYILPKIDHQDQDAVILGYGVYKRAMEDSFHLEHIKEELYKTQSSDVNGEKKEKINAKKTEQEMEFAEEETFPEDNENRNEFVREGEDSKEPGRLNPVGVIVPAAVLICGLAAAILKGYLPHVEMETILGVIVIAIAGIMLGLRIIKTKKVLHLPEQAYASGETVRHIEKIRNMPSWNKTEKKTSGKRSGWKEAEGKVSGQKWEDRLYENLSQTVERNQQTNQSQPVNGQKMSDCGQKTSKSSRIHMDYGETVVLSAGTVSGPASLVSKEPGELATIYLNEDLTVIGKLETACDAVVSLPTVSRIHAKIRKKEENYFLSDMNSRNGTSVNGRLLRPDEEYQLEPEDEVDFAQARYIFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZD27</accession>
    <name>A0A173ZD27_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00934</name>
        <name evidence="2" type="ORF">GT728_01350</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707032.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73579">
        <property type="protein sequence ID" value="CUN73579"/>
        <property type="gene ID" value="ERS852478_00934"/>
    </dbReference>
    <dbReference type="GeneID" id="66493049"/>
    <dbReference type="eggNOG" id="ENOG5032UY9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN73579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL31878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="143" mass="17195" checksum="C06004DCEB5C3D39" modified="2016-09-07" version="1">MHKWNEITDENSLKEFMERVSFFHDSCIKEMHYLSGAYVNENLDMYPVNDRRILRVIIQRQYEEDSMIEMEFQGLKYLKLFPADERYSCEILDSNIILKEDCIIWSDCEDKTELEDGDTGTLVCASKLRWRSIFGYMGEKNYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZFT1</accession>
    <name>A0A173ZFT1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="9">3.5.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nagA_1</name>
        <name evidence="9" type="ORF">ERS852478_00982</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199869.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75094">
        <property type="protein sequence ID" value="CUN75094"/>
        <property type="gene ID" value="ERS852478_00982"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047419">
        <property type="term" value="F:N-acetylgalactosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="8">
        <location>
            <begin position="47"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="301"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN75094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="367" mass="39699" checksum="B6BAE1F069D47E1C" modified="2016-09-07" version="1">MIIKNGNVFQEDGSYKVTDLYIENGRIAASEDEVTDKTQLDAAGLKVLPGLVDIHSHGAVRHDFSDADVDGLKIILQYEKSQGITSYCPTSMTLPKEELLKIFQTAKDVEQDETCARIVGINMEGPFLDPSKKGAHVEGYIRKPDIEFFRECNEAAGGLIKLVTLAPNMEGSEEFIRELHNEVVISVGHTAADYNCAAEAMKQGALHVTHLYNAMNPMGHREPGVIGAAADNENCMVELIGDGIHIHPATVRNTFRLFGDSRVVLISDSMMATGMENGIYELGGQEVTMKDRKATLADGTIAGSATCLFGCMKSVISMGVPEREAILAATANPARSIGIYDEVGSLTPGKRADIVLTDEELNIVKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZH23</accession>
    <name>A0A173ZH23_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199878.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75524">
        <property type="protein sequence ID" value="CUN75524"/>
        <property type="gene ID" value="ERS852478_00994"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503326E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046169">
        <property type="entry name" value="DUF6171"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19668">
        <property type="entry name" value="DUF6171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN75524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="90" mass="10667" checksum="3C9A7E31A3500D8E" modified="2016-09-07" version="1">MNRKLRVCRKCLPGQKNEEAFYEDLSRYIQRMDEELKVDQQTYEKRLGICSSCERLMSGMCRLCGCFVELRAVQKVRKCPDLPAKWEAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZJI5</accession>
    <name>A0A173ZJI5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lacE_1</name>
        <name evidence="3" type="ORF">ERS852478_00988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199873.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75325">
        <property type="protein sequence ID" value="CUN75325"/>
        <property type="gene ID" value="ERS852478_00988"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016944" evidence="2">
        <location>
            <begin position="29"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN75325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="464" mass="51919" checksum="F9CC3C1752C94ABE" modified="2016-09-07" version="1">MKRRKLFALLMTAAMAVSSMSMAVNVFAEEDTTEEAAESEEPAEGEPTAVTTVGPDDGTKYEMWSFVDLHNEFYGKMVEKWNEENPDKQIQVTFSTYPYSDMHNKLMMSLQAGSGAPDLCDIEIGQFPNYSGDDSPLYSMNDALAPYEDTMVQSRLDVYSKADGTRLGVPFHVGATVMYWNADLLESYGLDYKSVKTWDDYTKLGEELKEASNGEVYLTSVDTGGVDWMWLAMAENGEDWTGGPDGTVNVQLDSVKEMLTMQQNWLNDGIAMVSTDGHVDLEAGFSNIMDGKIASFPKAMWYMSRFKDYMPEMEGKYDITTCPVFEEGQKCSVGIGGTGTVVTNQCENPELAAEWLAWAKCSEEGENLIWNELGFDVCNTALWSDEAFAYDESNTYNTFFRVKPYEVLNELAENDAIGTVYTTKNSPTLNDYMCTTTLNNVLEDGMDVEEALQDAQDYLDFECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZK99</accession>
    <name>A0A173ZK99_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein BlaR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">blaR1_2</name>
        <name evidence="4" type="synonym">blaR1_1</name>
        <name evidence="4" type="ORF">BWLFYP14_01391</name>
        <name evidence="3" type="ORF">ERS852478_01016</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76243">
        <property type="protein sequence ID" value="CUN76243"/>
        <property type="gene ID" value="ERS852478_01016"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="2">
        <location>
            <begin position="3"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN76243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="674" mass="76115" checksum="F02CAB44CB2FD6E7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZL52</accession>
    <name>A0A173ZL52_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199880.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76196">
        <property type="protein sequence ID" value="CUN76196"/>
        <property type="gene ID" value="ERS852478_01014"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z93T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN76196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="347" mass="41643" checksum="8B37D7BB518616FD" modified="2016-09-07" version="1">MAYQFTRQEPCYDHILFVLALDRDKMKERILIGTEQQIRFRLDGNKDNDVIYDITRPLGRFLIDFEYDKEKNWNIYGLAPLRDALHTNRWKQPALEQTAGDFLAKKYLTGDPVRMYATFRIWNEYLVTREYRDRNTACDRFIEKIQILTQAFQTENVMNFNSDTGKPERFHTGSLYFRNTPAEITRLELWFPDNRRRTECVAAYSSFYPLITYYLNRLNDWGLCFRQCKVCGKYFLAKSQRYELCSDKCRKAQALQNKREFDERARENNYDLLYKNECQNWRNKINKSQKTANFPIERLEEMKNAFDLFKKEALQRKKAVKAGATSPTEFTDWLYQQNNIILKLSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZRS7</accession>
    <name>A0A173ZRS7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">sensor Histidine kinase GRAS</fullName>
            <ecNumber evidence="5 6">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">graS_1</name>
        <name evidence="6" type="ORF">BWLFYP14_00328</name>
        <name evidence="5" type="ORF">ERS852478_01048</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="5 6"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060445.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78280">
        <property type="protein sequence ID" value="CUN78280"/>
        <property type="gene ID" value="ERS852478_01048"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="124"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN78280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX67483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="350" mass="40500" checksum="F6EEECF1A7AB467A" modified="2016-09-07" version="1">MKLFLDYISKIKFYIILQLFPVMLAEIIFFLYQLPIEPMVYVTVFWLITGICACLNGFYRYRKKVEQLELIAAAPDINLSQMDSPVGQDERFQQEIMQQLNQMRIDVENASQKASEDMTDYYTMWAHQIKTPIFALRLLLQESPEENKEKLSELFKIEQYVEMVLGYLRTEDMSSDLKLSRCSLDRIIRDQIHKYAGIFVSKKLTLTYESISQDVLTDEKWLGFVIGQILSNALKYTRTGGIRIYLEKKLSLDTDDVSISIGNDDCNKVENFTLVIEDTGIGIRAEDIPRIFEKGYTGVNGRDDNRATGIGLYLSNKIMRKLGHRLYITSTEGKGTKVFLEFSVEDLSMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZTH3</accession>
    <name>A0A173ZTH3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Copper export regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hmrR</name>
        <name evidence="3" type="ORF">ERS852478_01090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199918.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79762">
        <property type="protein sequence ID" value="CUN79762"/>
        <property type="gene ID" value="ERS852478_01090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012867">
        <property type="entry name" value="DUF1648"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07853">
        <property type="entry name" value="DUF1648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN79762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="281" mass="32656" checksum="4DE7CCC7D986A39A" modified="2016-09-07" version="1">MTIKDVEERTGLSRSNIRFYEKEKLIEPSRNESNGYRDYSENDVENIKKIAYLRTLGISIEDIRSIISEKVTLQEMLEKHKEVLKNQITDLNKAKLMCEKMPDEESISYEKLQVEQYVTDLHDYWKDNRTVFKLDSVSFLYIWGSMLTWTILTALCLIIGALSYSKLPTEIPVQWSKGVATSLVNKNWIFICPVICIIIRYLLKPFIYAKLQMNNYYGEIITEYLTNYMCFIVLSVEIFSILFTFGVVKSVVVLLFVDTAIFIGLLVVGLVKMDLRGKEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ABW4</accession>
    <name>A0A174ABW4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV secretory pathway, VirB4 components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199979.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86101">
        <property type="protein sequence ID" value="CUN86101"/>
        <property type="gene ID" value="ERS852478_01237"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043964">
        <property type="entry name" value="P-loop_TraG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19044">
        <property type="entry name" value="P-loop_TraG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P-loop_TraG" evidence="1">
        <location>
            <begin position="431"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN86101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="777" mass="88860" checksum="28BE3D9CA22E0E0B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ADW4</accession>
    <name>A0A174ADW4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF3801)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199983.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86393">
        <property type="protein sequence ID" value="CUN86393"/>
        <property type="gene ID" value="ERS852478_01244"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZT0F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024234">
        <property type="entry name" value="DUF3801"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12687">
        <property type="entry name" value="DUF3801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN86393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="270" mass="29787" checksum="CD9FCF119933E1EE" modified="2016-09-07" version="1">MNTGGEAAEQIVRMSLEGFEVAAKITGAGAKNIAILLYSILKEEKKTKGKARLTSMLRSGKELKVFTVKSGDLKKFTQEAKKYGVLYCVLTDRKNKDPNAEVDVIARAEDASKISRIVERFNLASVDTASIVTEAEKSKDAKDGQPEPDIGVQEKAEKDKLLDELMGKPVQKEENAPNPSVAKTEKSPQSEPTSEQPKKSAEGATMTKEKPSVREELRKIKESRKEQEAEIGTSDLDKSGASDRAKSANRKTEHKQPTRKKKKPKSKETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AEF6</accession>
    <name>A0A174AEF6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01254</name>
        <name evidence="4" type="ORF">GT728_16815</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000053">
        <property type="protein sequence ID" value="MZL34807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007037034.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86744">
        <property type="protein sequence ID" value="CUN86744"/>
        <property type="gene ID" value="ERS852478_01254"/>
    </dbReference>
    <dbReference type="GeneID" id="61860930"/>
    <dbReference type="eggNOG" id="COG3935">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046059">
        <property type="entry name" value="DUF6017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19481">
        <property type="entry name" value="DUF6017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6017" evidence="2">
        <location>
            <begin position="158"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN86744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="327" mass="37237" checksum="932E1212E17F8434" modified="2016-09-07" version="1">MAVFRVERNKGYTVMSNHHLRNKELSLKAKGLLSQMLSLPEDWDYTLKGLSLINREKIDAIREAIKELERAGYIVRSRERDEKGRLRGADYVIFEQPQPPTPDLPTLENPTLDNPMQEKPTLEKPTLENPTQLNKDIQRTDLPKKEKSNTDLSSTHSIPILSPNPSPCREAAAPPERKGTEAAAQSAVDIYREIIKDNIDYHILKQDMKFDSDRLDEIVDLMLETVCTARKRVRIAGDDYPAELVKSKFMKLDGEHIRFVLDCMRENTTKIRNIKQYLKAALFNAPSTIGNYYTSLVAHDMASGALSPKKPQYGDPDYYSCNEGESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AFQ2</accession>
    <name>A0A174AFQ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006857246.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000069.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86335">
        <property type="protein sequence ID" value="CUN86335"/>
        <property type="gene ID" value="ERS852478_01242"/>
    </dbReference>
    <dbReference type="GeneID" id="61431728"/>
    <dbReference type="eggNOG" id="ENOG503369F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN86335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="65" mass="7727" checksum="7F67CDACB3FA2A75" modified="2016-09-07" version="1">MREERYHIALDKYDKNIVINALNTLRTRQLQEERPTEPVDELISKVAHAPTKKVKVVHCRCNEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ALW6</accession>
    <name>A0A174ALW6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lipid kinase YtlR</fullName>
            <ecNumber evidence="2">2.7.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ytlR</name>
        <name evidence="2" type="ORF">ERS852478_01327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200015.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89273">
        <property type="protein sequence ID" value="CUN89273"/>
        <property type="gene ID" value="ERS852478_01327"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN89273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="321" mass="35660" checksum="F676DE1A36C94C56" modified="2016-09-07" version="1">MRRIQIIVNNGAGTGQAHRVWNETQRLLRGYKIKYVAHTTRYQGHATKLAEKISSMKGDDPIYLIVIGGDGTLNEVLNGITDFDRVRLGVIPTGSGNDFGRNLKLPKTPKESLKQICASIRKDQRGEELYRIDLGQVSWDGCDKPRIFGISAGLGLDALVCKKALHSRLKQVLNRFHLGKLTYLALTVQSLFTMETANAKVITEHGGFILPKMIFAAAMNLPAEGGGVPMAPEASPEDGRLSLSSASGIAKWQTFFLLPFLVAAKQERINGFNIREENGFRVLLDKPMVLHADGEYCGDVTRVEFRCLEKRLWLLHEKEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B230</accession>
    <name>A0A174B230_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParB/RepB/Spo0J family partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01430</name>
        <name evidence="3" type="ORF">ERS852523_01011</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP24812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993766.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93806">
        <property type="protein sequence ID" value="CUN93806"/>
        <property type="gene ID" value="ERS852478_01430"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP24812">
        <property type="protein sequence ID" value="CUP24812"/>
        <property type="gene ID" value="ERS852523_01011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="13"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN93806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP24812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="173" mass="19802" checksum="EE7FA5DCD80F58EF" modified="2016-09-07" version="1">MDSKLTAPLSTLRWVDRNLLKPNDYNPNKVSKENLKLLIQSILTNGWTLPIVVRPDMTIIDGFHRWTVAGMEPLLSKLDGKVPIVIVEHKEHSEDIYGTVTHNRARGTHLLEPMKKIVKELMDEGKTVEEIGKQLGMRPEEIFRLSDFSKEDFLKMMTKGVTGYSKAEFITKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B2G5</accession>
    <name>A0A174B2G5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93835">
        <property type="protein sequence ID" value="CUN93835"/>
        <property type="gene ID" value="ERS852478_01431"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018925">
        <property type="entry name" value="Phage_terminase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10668">
        <property type="entry name" value="Phage_terminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN93835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="266" mass="30362" checksum="CFFB8C682F4BFB2D" modified="2016-09-07" version="1">MARARSPNSIEAEEMYKRGMKLVDIAKKLDVPASTVRRWKSTQNWDGDTKKKKSERSPKKKANARHKGGQLGNKNAVGNKGGPLKPGDKIAEKHGAYSSVYWDVLDESEKDMIEDIPMDEEMLLIEQIQLFAVRERRIMAAINKYRNMNGEVSLFGFTRTEDKRAFKSDEDKQLYEERIEEKVASGDRLPGNTYNMMTNMENKDNMIARLEKELSTVQSKKTKAIEALAKLRLEKQKIAGESKGNEVVRAWAEAVVKARREEKHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B5T3</accession>
    <name>A0A174B5T3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95559">
        <property type="protein sequence ID" value="CUN95559"/>
        <property type="gene ID" value="ERS852478_01483"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030J0V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN95559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="126" mass="14693" checksum="D37A93404F07022F" modified="2016-09-07" version="1">MQQRQGYQAVEKLRETLDEKYLWEVILLYAGESFKTYTGLPFTYEVRKGRNGDYTRELWIDRRENSKSLALSSVLLALRNIKKVGAVVDRPKALGDIRGVSYIYGIFYRFGLIDVPDTARQKMKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BLP4</accession>
    <name>A0A174BLP4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01473">
        <property type="protein sequence ID" value="CUO01473"/>
        <property type="gene ID" value="ERS852478_01622"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO01473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="107" mass="12128" checksum="D6C1C49DAF9C0DBE" modified="2016-09-07" version="1">MLRAVLNLMRGGLVDGNIAAGAQLAADRQAAFYCMEYTKAYQGKAAFAKQKKQQRRARQKKETRDNLAKEEILQDDRFFFIAGYTSGGAPYGVTWEEMGLKPWEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C884</accession>
    <name>A0A174C884_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Domain of uncharacterized function (DUF2088)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200280.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08105">
        <property type="protein sequence ID" value="CUO08105"/>
        <property type="gene ID" value="ERS852478_01804"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lar_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO08105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="495" mass="56228" checksum="501DBB992C9E5BA3" modified="2016-09-07" version="1">MKLNFEYGQGTMAAELPDNTDVFIPGETVKDPAYIPEDQLEAAYLESLAHPIGMPTLTELAGPGKTVTIVVPDRVKGGEQATSHRKLSIKYILKELYAAGIEKKDILFIISNGLHPRSTEADAKAIFGEELFNEFWHTGQIISHDSEDQEHMVYLGTTHRGDPVYMNKYVFECDIPILIGHVQGNPYGGYSGGYKHSATGITNWRCIASHHVPSVMHRDDFTPVNGGSLMRNKFDEISMHMEEKMGHPFFCCDAVLDTQSRQIAIYSGYAKEMMPISWKLADKRTYVHWAEKKYDVLVFGMPQNFHYGDGMGTNPIMMMQALSAQVLRFKRVMSDNCVIICSSICNGYFHDERWPYLRELYDLFQHDHMNTLPDMNRLGEYFATNEEYIRKYRYTNAFHPFHGFSMMSCGHIAEMNTSAIYIVGAEEPGYARGMGLKTRATFEEALEDAKKKYVGQEPNILALPMTFKKAAVHLCMKDPAQDCMDEYGHRHPCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C9D1</accession>
    <name>A0A174C9D1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200347.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10141">
        <property type="protein sequence ID" value="CUO10141"/>
        <property type="gene ID" value="ERS852478_01845"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019064" evidence="1">
        <location>
            <begin position="26"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO10141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="269" mass="29673" checksum="6FD0124685D8FF49" modified="2016-09-07" version="1">MKKKIMMVVLAGVLIGSMESAMVYAGRMPELTKTESSNKSSIWEDYLKEHSERGVKEQFIKEHVGDLSDEQLDHMIGAYFGDEGTLDEEDSCNDGDEDPDEFPVSLYSYTFQEEIGGNDYDFVQYTAVVNQGSGSVQVLLPKGCKFVTGYGKLTDGYRAYDSLDEAVQKGEDICLSEGLSENLPDSNVICWDAKGDGTYTFAVEKTGDAEDDAIWLVDGYGYTGSEDLTGKVTEPDEDLDSDMLVGGALSEESYHGTLDGDLFFLLRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CEK6</accession>
    <name>A0A174CEK6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01894</name>
        <name evidence="4" type="ORF">GT712_19125</name>
        <name evidence="3" type="ORF">GT728_21250</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000123">
        <property type="protein sequence ID" value="MZL35617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000069">
        <property type="protein sequence ID" value="MZS91091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053633.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000123.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11614">
        <property type="protein sequence ID" value="CUO11614"/>
        <property type="gene ID" value="ERS852478_01894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO11614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL35617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS91091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="145" mass="17008" checksum="904F9DBB92B1A59C" modified="2016-09-07" version="1">MGLKRGLWRSTGIGRTIDTVKNIVDEGSISGGVKRMIKEDLTEDNPLGKMIYDSGRYDGKKEGYEEASAEYEHKLIEQADLFLKQTRVFEEERDEYEKLLDEYDKEIELLENKADKTDRENKYLQELLLKERKLIQLIPEDEDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CFV8</accession>
    <name>A0A174CFV8_9FIRM</name>
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        <submittedName>
            <fullName evidence="1">Iron-responsive transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
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            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200388.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10860">
        <property type="protein sequence ID" value="CUO10860"/>
        <property type="gene ID" value="ERS852478_01868"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO10860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="143" mass="15974" checksum="08430733FAF4198F" modified="2016-09-07" version="1">MIITKETDYAMRILRVLLDGEKHSVAEISKTELIPTQFAYQILRKLSAGNLVRVSRGALGGCALSCDPDATSLYDLMGVMGERGVLHACMEPGYECRWQNEHGRCAIHYQLAALQRKQDEAFRAVSLRRLLTGGYDPQDTSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CIA5</accession>
    <name>A0A174CIA5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exo-beta-D-glucosaminidase</fullName>
            <ecNumber evidence="6">3.2.1.165</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">csxA</name>
        <name evidence="6" type="ORF">ERS852478_01896</name>
        <name evidence="8" type="ORF">GT712_19505</name>
        <name evidence="7" type="ORF">GT728_10855</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">BIOML-A1</strain>
            <strain evidence="8 10">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.165" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000023">
        <property type="protein sequence ID" value="MZL33684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000078">
        <property type="protein sequence ID" value="MZS91157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060012.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11670">
        <property type="protein sequence ID" value="CUO11670"/>
        <property type="gene ID" value="ERS852478_01896"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052761">
        <property type="term" value="F:exo-1,4-beta-D-glucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="219"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Ig_mannosidase" evidence="5">
        <location>
            <begin position="755"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO11670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS91157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="821" mass="96251" checksum="2007E8F1D4292248" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CNG4</accession>
    <name>A0A174CNG4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BlaI/MecI/CopY family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Penicillinase repressor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Regulatory protein BlaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">blaI_4</name>
        <name evidence="4" type="synonym">blaI_3</name>
        <name evidence="4" type="ORF">BWLFYP14_02174</name>
        <name evidence="2" type="ORF">ERS852478_01959</name>
        <name evidence="3" type="ORF">GT728_15095</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000042">
        <property type="protein sequence ID" value="MZL34488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703603.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13709">
        <property type="protein sequence ID" value="CUO13709"/>
        <property type="gene ID" value="ERS852478_01959"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO13709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="129" mass="15008" checksum="24ABC40EB240F130" modified="2016-09-07" version="1">MKKTYQRLPESELDIMLVLWNNTPPMTRPEIEKVINTKKKLASTTILSLLTRLENKNFVEVTKQGKMNLYTPLVSQSDYQAHESQSVLEKLYGNSLKKFVTSLYHGKKISSEEVQDLSEFLKNLEDREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D1I6</accession>
    <name>A0A174D1I6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200530.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17878">
        <property type="protein sequence ID" value="CUO17878"/>
        <property type="gene ID" value="ERS852478_02067"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019636" evidence="2">
        <location>
            <begin position="20"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO17878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="362" mass="38553" checksum="73E52371F2763B0E" modified="2016-09-07" version="1">MKKRYLILAGLLVMTVAAAGCGKKKTTETAPVEVTATPTPEVTKAVDMVDMQQTADEDIKNVMGEKTSTASKIVFVNNTGDDIQSLYIRTHVDEDSEDYDADEDGGWGDDLINGMFTLTDKDKALYYMQTANTQTANTQTTDTQTTDTQTTSNKSTASYDIRIAYADEDKNECFFRDIPLGTISQITLCMDGTDDDAIPYAKYLTGTSTKEVSTLDAVKERLGITDDSKSESDSTDDSDKNSTDNSDSADNNNSGDQNTDDNGNGSNNGSDDGNGGSTDNGNGGNGGGGNTDQDNNGGDMISIAEQYIGQSLDALEGACGSPQGSSYEDDPETGKTGFHYYSNFTVSTTVDENGNEIVAGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D1K9</accession>
    <name>A0A174D1K9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-IPM isomerase</fullName>
            <shortName evidence="6">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hacA</name>
        <name evidence="6" type="synonym">leuC</name>
        <name evidence="8" type="ORF">ERS852478_02100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380261.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19551">
        <property type="protein sequence ID" value="CUO19551"/>
        <property type="gene ID" value="ERS852478_02100"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01027">
        <property type="entry name" value="LeuC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011826">
        <property type="entry name" value="HAcnase/IPMdehydase_lsu_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006251">
        <property type="entry name" value="Homoacnase/IPMdehydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01343">
        <property type="entry name" value="hacA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02086">
        <property type="entry name" value="IPMI_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="5 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase" evidence="7">
        <location>
            <begin position="280"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO19551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="415" mass="44983" checksum="84B06DCEF840A998" modified="2016-09-07" version="1">MGETVIEKIIRNNVGKTVKPGDIVTVNVDRVMIHDIFIPFVAEKFEEMGFTKLWNPDKAVLIYDHLVPASQLDDTRHFHAGDAFARKYGMKNVHRSDGICHQLMTEAGYVKPGNIVFGTDSHTTTYGCVGAFSSGIGYTEMASILGTGTMWIKVPETIKVVIEGELPENVMSKDIILRLIGDLGADGATYRALEFTGSTVKNMTVASRMTMANMAIEAGAKCALFTPDEKTAEYCDIELNEFQKSLTGDEDATYMKTITYRAEDFVPVMACPSQVDKIKNVSELEGTEIDQVFIGSCTNGRLEDLRAAAEVLKGKKVADYVKLIVTPASRKIYCQAIAEGIMDTLAEAGAMITHPGCGLCCGRAGGILTDGERVVATNNRNFLGRMGTSKVEIYLASPKTAAACAIAGKIVNPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D8B9</accession>
    <name>A0A174D8B9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20519">
        <property type="protein sequence ID" value="CUO20519"/>
        <property type="gene ID" value="ERS852478_02132"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZCH7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO20519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="127" mass="14437" checksum="7BEAF7069CE64D82" modified="2016-09-07" version="1">MSENNDYIQLPPLKKDTPADVVAFMWEYMKVPEDSREKVKNLLKDANENGVKISHQAPTLYDVVPKEEIAEFEELMRKTIADIVSEASSVRCLLGVCAEICEAQNPKRNAARIARRRSIHPSYGYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D9B9</accession>
    <name>A0A174D9B9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication initiator protein A (RepA) N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580966.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20588">
        <property type="protein sequence ID" value="CUO20588"/>
        <property type="gene ID" value="ERS852478_02134"/>
    </dbReference>
    <dbReference type="GeneID" id="66495351"/>
    <dbReference type="eggNOG" id="ENOG502Z8BZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046059">
        <property type="entry name" value="DUF6017"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010724">
        <property type="entry name" value="RepA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19481">
        <property type="entry name" value="DUF6017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06970">
        <property type="entry name" value="RepA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RepA_N" evidence="2">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6017" evidence="3">
        <location>
            <begin position="213"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO20588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="332" mass="38921" checksum="8028B1AC12B81C59" modified="2016-09-07" version="1">MEKKMTFNYFYGTEADQFSFYRIPKALFTDSYFKDLSSDAKILYGLMLDRMSLSIKNQWFDDKNRAYIYFSIEDIMELLNCGRNKAIKSMRELDDETGIGLIEKRRQGFGKVNVIYVKTFMPEKTDEKKFEEELKKFKKQTSVENEESTEVYNSNFMKSQNQTSRSPENKLQEVYISNPNNTNLSDTEMNDNKSNPIISVDEKRFDSDNHSEDYQAYENLVKETIDYESLKVTHHDDMRKVDEIVNLIVETVMCKNDKILIASNWYPASLVKKKFLMLTYSHIEYVLHCMSGNTTKVKNIKKYLLAALFNAPSTMNGYYQAEVNHDMPGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DBH4</accession>
    <name>A0A174DBH4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA1(Val) (Adenine(37)-N6)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.223</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yfiC</name>
        <name evidence="2" type="ORF">ERS852478_02209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.223" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707975.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22904">
        <property type="protein sequence ID" value="CUO22904"/>
        <property type="gene ID" value="ERS852478_02209"/>
    </dbReference>
    <dbReference type="GeneID" id="66493400"/>
    <dbReference type="eggNOG" id="COG4123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="35"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO22904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="246" mass="27814" checksum="8D36D08AB83C975E" modified="2016-09-07" version="1">MTDQLVKDNERIDDLQNGYYVIQDPDKFCFGMDAVLLSGFAKVKKGETALDLGTGTGIIPILLKTKTNGKHFTGLEIQKECADMAGRSVRYNHLEDDVEIVRGDIKEAADIFGAASFDVVTSNPPYMIGQHGLRNSDMPKAIARHEVLCNLEDVVSQASKVLKERGRFYMVHRPFRLAEIMNVLTKYRLEPKRMQLVYPYIDREPNMVLIEALKGGNSRVTVEPPLIVYKEPGVYTENILKIYDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DJE9</accession>
    <name>A0A174DJE9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycerol-1-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="11">1.1.1.261</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">egsA</name>
        <name evidence="11" type="ORF">ERS852478_02281</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.261" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200671.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25623">
        <property type="protein sequence ID" value="CUO25623"/>
        <property type="gene ID" value="ERS852478_02281"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050492">
        <property type="term" value="F:glycerol-1-phosphate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0533">Nickel</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO25623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="424" mass="47183" checksum="89D27F9743BF62CF" modified="2016-09-07" version="1">MRVDADDFARPCSCGREHQIAVKEILIEAGAVEKLEEEMSEGMLREYISPLVICDTNIYAATEELMEDIYDRCQVLVLDAEGLQADRHAIKIVENNMEEDIDLILAVGAGTIHDISRYIAHNYKVPFISVPTAASGDGFVTTVAAITLDGVKKTVPSVAPICVYADTDIFSKAPQRLTAAGISDLMAKYICLADWKIANLVTGEYFCRETVKLEEKALKTVKSSIQDITEGEEDECEQLMYALILSGLAMQMIGNSRPASCAEHQVTHLWDMEVINGPLDALHGEKVSVAAFLVLEEYKRIAAAITQGRCHAKPYENEDEELLKETFGKKGLLEEIRKENEPELLETISPQHLEKCLNGIEEIIDELPSEQTMFRLLEKAGCAKTVYDIGLDESAVLPSLRLAPYTRRRLSLLRISKMLDIRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DK81</accession>
    <name>A0A174DK81_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yehT_1</name>
        <name evidence="10" type="synonym">yehT_2</name>
        <name evidence="10" type="ORF">BWLFYP14_01537</name>
        <name evidence="8" type="ORF">ERS852478_02291</name>
        <name evidence="9" type="ORF">GT728_12135</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000029">
        <property type="protein sequence ID" value="MZL33928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200685.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25981">
        <property type="protein sequence ID" value="CUO25981"/>
        <property type="gene ID" value="ERS852478_02291"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="135"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO25981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX64683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="240" mass="28280" checksum="C4CC5D7F0E9F94DE" modified="2016-09-07" version="1">MFCIGICDDDEGLCGELEKMLYDYGKENKLQMNIDIWYQGESLCRFLRENKKILDVLFLDIELLTTNGIEVGRFIREEQENMETAIVYISANSSYAMDLFRVQPTDFLIKPLDKIKVGNVMNRIQKISEVRKGIFEYFGSGYYFKVLYKDILYFSSQNKKVHLVLKDGQKEFNGKLKEIAKKIPGNFIQIHQSYLINFDYIEECSYESVKMKNGDTIPISQPYRKSVRTQLAERVWRERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DUE8</accession>
    <name>A0A174DUE8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200717.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29074">
        <property type="protein sequence ID" value="CUO29074"/>
        <property type="gene ID" value="ERS852478_02371"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033JXR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020238" evidence="1">
        <location>
            <begin position="27"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO29074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="270" mass="29563" checksum="0867F28712F29F2B" modified="2016-09-07" version="1">MKNWKKLMAGFCVAAMVSSMVVPVWATDDAAAEEDADGDVADVSEAMLGLWKDSAGDIYGFYKDNSFFGQWKDEEQDVLGVYALSSDGEYTALVMQFANDDGTYDDENMVTYLVQANEEENLLELYDEENLELTATLEPYQADGDEADYNQTYQDMGDILTECYSGETEAGETFIYAANEDGTFCSVLVIDQDDNYVSFVGEGTFDEENGTVTITDEVSEMALTFGVTLNDDDTLTLDMGDLGSATVQEATLAVAVQGLKYAVENGTEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E252</accession>
    <name>A0A174E252_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">immunity protein SdPI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sdpI</name>
        <name evidence="3" type="ORF">BWLFYP14_00119</name>
        <name evidence="2" type="ORF">ERS852478_02417</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060044.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30568">
        <property type="protein sequence ID" value="CUO30568"/>
        <property type="gene ID" value="ERS852478_02417"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026272">
        <property type="entry name" value="SdpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025962">
        <property type="entry name" value="SdpI/YhfL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37810:SF5">
        <property type="entry name" value="PTHR37810:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13630">
        <property type="entry name" value="SdpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO30568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="342" mass="38943" checksum="0F603B656926690E" modified="2016-09-07" version="1">MKEMIKKYKGTLICSVLVMLAGILVGFTMAQSIWINVFFVVTDCILVTIIFYDNRNRQQSSKVIGMVIWMIPVTALIYNGMARLISMDADSENLFMAVIYFGTGLLFMIIGNYLPKVKQNNTIGIRVVWTLQDEENWSATHRFSGKLWVASGVLCMLCGLFGESIAALVLYIVSIMAAAIVSILYSYLFYKKKMAAGEKLKIQYNKKTIVIYVIVSVFVVIFTIWTLFWGGIDISFHDNDFTVEAQGWSDYTVDYEQIDSISYKENLFQNGNDRRTNGMGNLKYGMGNFRNDIYGDYIRYTHASCHSYVVMDIGGKILVVNGVDESETKKIYDTLREKCQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E5S8</accession>
    <name>A0A174E5S8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-acetyl-ADP-ribose deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ymdB_1</name>
        <name evidence="2" type="ORF">ERS852478_02493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200775.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33131">
        <property type="protein sequence ID" value="CUO33131"/>
        <property type="gene ID" value="ERS852478_02493"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO33131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="175" mass="19057" checksum="AF99A239F1D2B700" modified="2016-09-07" version="1">MELLKTIRGDITKITDVQAIVNAANNSLLGGGGVDGAIHRAAGPELLEECRTLHGCETGKAKITKAYKLPCEYVIHTVGPIWNGGNQNEKELLASCYLSSMQLTLEHKIRKIAFPSISTGVYSFPVGLAARIAVNTVAGFLKEHPDDFDLVEWVLFDEHTELVYAIEVNAHNKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ED11</accession>
    <name>A0A174ED11_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional (P)ppGpp synthase/hydrolase RelA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">relA_2</name>
        <name evidence="3" type="ORF">ERS852478_02570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380776.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35772">
        <property type="protein sequence ID" value="CUO35772"/>
        <property type="gene ID" value="ERS852478_02570"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="2">
        <location>
            <begin position="84"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO35772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="329" mass="38543" checksum="EB5926FFE9B7FF4F" modified="2016-09-07" version="1">MITLNDYLYSGDTVLKILQKYTRDLRKEAKLTHNEIDMMHVNFLIQITELLEHNDFLTAQSQKIREFYKYMAHEYPFLAFTFKGRIKSLIRAEEKFNGYIVEYIYDYYTKHGTYPPVSELKNKLSCFRDFIAYRIVLCMPKCHLKPGEDQETASIRYLYEIANVLPGFLEERGFTVESAYGVKKSTSPLLNEDVKMYYRDYICGTSGEGYQSLHITVYDNSSRSFMEVQLRTQKMDDTAEIGPANHLGYEKRQQDERARRDAIPEGESVYFDEAYERGMRLLQLELADLDVNMFSAVDNSLINDGCGLFRGRLILPYEHLSRFQNDVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EKL6</accession>
    <name>A0A174EKL6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="13">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="13">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">pheS</name>
        <name evidence="18" type="ORF">BWLFYP14_02474</name>
        <name evidence="16" type="ORF">ERS852478_02606</name>
        <name evidence="17" type="ORF">ERS852523_00203</name>
    </gene>
    <organism evidence="16 19">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 19 20" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 19">2789STDY5834863</strain>
            <strain evidence="17 20">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="18 21" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="13"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000002">
        <property type="protein sequence ID" value="CUP00146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000050">
        <property type="protein sequence ID" value="VUX66102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000003_gene1620"/>
    <dbReference type="EnsemblBacteria" id="CUO36775">
        <property type="protein sequence ID" value="CUO36775"/>
        <property type="gene ID" value="ERS852478_02606"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00146">
        <property type="protein sequence ID" value="CUP00146"/>
        <property type="gene ID" value="ERS852523_00203"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="15">
        <location>
            <begin position="119"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUO36775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUP00146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VUX66102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="341" mass="38598" checksum="A064617141BD4909" modified="2016-09-07" version="1">MDMKERLQELAEAAGKRISESEGLEKLNEVRVAYLGKKGELTAILKSMKDVAPEERPKVGQLVNETRSKIEALLDESKQKLEEAAREEKMKQEVIDVTLPAKKAKIGHRHPNTIALEEVERIFIGMGYEVVEGPEVEYADYNFTKLNIPENHPARDEQDTFFINDSILLRSQTSPVQARTMEKGKLPIRMIAPGRVFRSDEVDATHSPSFHQIEGLVIDKNITFADLKGTLQEFAQELFGPETKTKFRPHHFPFTEPSAEVDVSCFKCGGKGCRFCKGSGWIEILGCGMVHPNVLSMCGIDPEEYTGFAFGVGLERIALLKYEIDDMRLLYENDIRFLKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EXJ6</accession>
    <name>A0A174EXJ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chlor_Arch_YYY domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200861.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40715">
        <property type="protein sequence ID" value="CUO40715"/>
        <property type="gene ID" value="ERS852478_02718"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018746">
        <property type="entry name" value="DUF2298"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10060">
        <property type="entry name" value="DUF2298"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03662">
        <property type="entry name" value="Chlor_Arch_YYY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO40715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="745" mass="84505" checksum="1CB3065484FC458C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F2K7</accession>
    <name>A0A174F2K7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neu5Ac permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">siaT_2</name>
        <name evidence="6" type="ORF">ERS852478_02788</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200924.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000020.1"/>
    </dbReference>
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        <property type="gene ID" value="ERS852478_02788"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="TRAP_DctP_sf"/>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="69"/>
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            <begin position="138"/>
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            <begin position="399"/>
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        <location>
            <begin position="7"/>
            <end position="420"/>
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        <source>
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    <sequence length="1110" mass="121303" checksum="EF19377D679A4078" modified="2016-09-07" version="1"> </sequence>
</entry>
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        </submittedName>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZS91209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX67144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="116" mass="13578" checksum="FD882ED367151798" modified="2016-09-07" version="1">MFIFLSACSLLVPLSMIILGYTWKDKPPKDRQGSSGYRTTMSRMNDETWRYAHRCWGWINFVLGIILVILSIFILILTKDDTNFEMISVYLVFLQLGIMVLTIIPTEFLLHKHFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FA62</accession>
    <name>A0A174FA62_9FIRM</name>
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        <recommendedName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
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        <name evidence="5 10" type="synonym">greA</name>
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        <name evidence="12" type="ORF">BWLFYP14_00829</name>
        <name evidence="8" type="ORF">ERS852478_02863</name>
        <name evidence="9" type="ORF">ERS852523_03702</name>
        <name evidence="11" type="ORF">GT712_16370</name>
        <name evidence="10" type="ORF">GT728_14385</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000061">
        <property type="protein sequence ID" value="CUQ03690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000038">
        <property type="protein sequence ID" value="MZL34354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZS90592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="VUX63243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705914.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000092_gene76"/>
    <dbReference type="EnsemblBacteria" id="CUO45240">
        <property type="protein sequence ID" value="CUO45240"/>
        <property type="gene ID" value="ERS852478_02863"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ03690">
        <property type="protein sequence ID" value="CUQ03690"/>
        <property type="gene ID" value="ERS852523_03702"/>
    </dbReference>
    <dbReference type="GeneID" id="66495193"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="6">
        <location>
            <begin position="80"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO45240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUQ03690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL34354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS90592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX63243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="166" mass="19299" checksum="3D33F95E5E8ABBCD" modified="2016-09-07" version="1">MKEKLTQKDVEKIQQEIDHRKLVVRKEAIEAVKEARAQGDLSENFEYYAAKKHKNQNESRIRYLENMLKTATIVSDDSKDDEVGMDDIVEVYFEEDDEIEKYKLVTSIRGNSMENRISIESPIGMALKGHKVGDRVEVKVNDNYSYFLEIRSIDKTGSEDEEIRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FGM3</accession>
    <name>A0A174FGM3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">apbE_2</name>
        <name evidence="11" type="ORF">ERS852478_02941</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201017.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47550">
        <property type="protein sequence ID" value="CUO47550"/>
        <property type="gene ID" value="ERS852478_02941"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948323" description="FAD:protein FMN transferase" evidence="10">
        <location>
            <begin position="37"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO47550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="366" mass="40279" checksum="67ABC536130E39B4" modified="2016-09-07" version="1">MILYHISAKKLITRCTFSMLAASLILCPAVFSGCSAKTENVKNTDAGSQDPISATAIKLNTAVTVTIYDSQDRELLTECMNLCDKYEKIFSRTADDSELYQLNHRELTPVKGTEDTYQVSASLAELVSKGLDYSALSEGAFDIAIEPLTSLWNFTAENPKVPKDSLIQAALPKCNYHNISVDTDKNEITLKTDDTAIELGAIAKGYIADRLKDYLVSQNVKSAIINLGGNVLCIGEKTDNSAFKIGIQKPFADRSETIAVMDIRDKSVVSSGIYERCFEQDGTLYHHLLNPKTGYPYDNGLIAVTIISDQSVDGDALSTTCFALGLEDGMKLAESLDDVQAFFVTSDYEIHYTRDFQKKIKVTETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FHC6</accession>
    <name>A0A174FHC6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">dapA</name>
        <name evidence="11" type="ORF">ERS852478_02977</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201044.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48937">
        <property type="protein sequence ID" value="CUO48937"/>
        <property type="gene ID" value="ERS852478_02977"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO48937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="297" mass="31561" checksum="08EA1269A8BAD788" modified="2016-09-07" version="1">MAIFKGAGVAIVTPMYEDGKVNYDKLEELLEYQIANSTDAIIICGTTGESSTMTHGEHLKTIKFAIDKVNKRVPVIAGTGSNCTETAIMMSKEAASYGADALLIVTPYYNKATQKGLIAHYTAIAEAVPETPIIMYNVPSRTGCNIQPATAVALAKNVKNIVGIKAASGDLSQIATMMSMADGCIELYSGNDDQVLPILSLGGLGVISVLSNVAPKETHDMVMKFLEGDTKGAAEIQLKAIPLIHALFSEVNPIPVKAALNLMGKEVGPLRMPLSEMEDANKAKLAEEMKNFGIKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FNY3</accession>
    <name>A0A174FNY3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacillus/Clostridium GerA spore germination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51972">
        <property type="protein sequence ID" value="CUO51972"/>
        <property type="gene ID" value="ERS852478_03063"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004995">
        <property type="entry name" value="Spore_Ger"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03323">
        <property type="entry name" value="GerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005690">
        <property type="entry name" value="GerBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO51972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="540" mass="60715" checksum="DD59362BC83BA58F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FP80</accession>
    <name>A0A174FP80_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjO_10</name>
        <name evidence="8" type="synonym">ycjO_11</name>
        <name evidence="7" type="ORF">ERS852478_03003</name>
        <name evidence="8" type="ORF">ERS852523_03207</name>
        <name evidence="9" type="ORF">GT728_10080</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
            <strain evidence="8 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO49945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000042">
        <property type="protein sequence ID" value="CUP90207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000021">
        <property type="protein sequence ID" value="MZL33536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577755.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000010_gene2785"/>
    <dbReference type="EnsemblBacteria" id="CUO49945">
        <property type="protein sequence ID" value="CUO49945"/>
        <property type="gene ID" value="ERS852478_03003"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP90207">
        <property type="protein sequence ID" value="CUP90207"/>
        <property type="gene ID" value="ERS852523_03207"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="69"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO49945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP90207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="301" mass="33853" checksum="F769EA2803EDF1BA" modified="2016-09-07" version="1">MKKAKFKRWAPLYLMMAPGLIYLFINNYMPMAGLVVAFKNYNVVDGIFGSPWAGLSNFTYLFNDAWTITRNTLLYNIVFIIINLILGIAFAIFICDIRSKACKTIYQSAILLPFLMSIVIVSYITFAFFSGDNGMLNKTILPFFGKEAINWYSESKYWPVILVIVNTWKGVGYGCLIYISSISGIDPSFYEAAELDGASKWKQIRYITLPSIMPSVITLTLLNIGRIFYSDFGLFYQVTQNSGQLYDTTNVIDTYVYRALLQSGNIGMASAAGFYQSIVGFACVLLANVVVRKLSPENAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FXL6</accession>
    <name>A0A174FXL6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acidobacterial duplicated orphan permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852478_03156</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO54964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201212.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54964">
        <property type="protein sequence ID" value="CUO54964"/>
        <property type="gene ID" value="ERS852478_03156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="644"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="21"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="287"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="678"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO54964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="777" mass="84842" checksum="390C504737382A4E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FYW7</accession>
    <name>A0A174FYW7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV secretory pathway, VirB4 components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201161.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53295">
        <property type="protein sequence ID" value="CUO53295"/>
        <property type="gene ID" value="ERS852478_03102"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO53295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="728" mass="81627" checksum="1757DD409E413C7D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GDI2</accession>
    <name>A0A174GDI2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO59086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201261.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59086">
        <property type="protein sequence ID" value="CUO59086"/>
        <property type="gene ID" value="ERS852478_03280"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="1">
        <location>
            <begin position="240"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO59086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="676" mass="75784" checksum="E819ED9B956AE945" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GF13</accession>
    <name>A0A174GF13_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Lipoprotein-releasing system ATP-binding protein LolD</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lolD_5</name>
        <name evidence="5" type="ORF">ERS852478_03292</name>
        <name evidence="6" type="ORF">ERS852523_03709</name>
        <name evidence="8" type="ORF">GT712_02555</name>
        <name evidence="7" type="ORF">GT728_17765</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
            <strain evidence="6 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">BIOML-A1</strain>
            <strain evidence="8 11">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO59449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000062">
        <property type="protein sequence ID" value="CUQ03956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000062">
        <property type="protein sequence ID" value="MZL34974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053974.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59449">
        <property type="protein sequence ID" value="CUO59449"/>
        <property type="gene ID" value="ERS852478_03292"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ03956">
        <property type="protein sequence ID" value="CUQ03956"/>
        <property type="gene ID" value="ERS852523_03709"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO59449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUQ03956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL34974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS87999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="223" mass="24095" checksum="B693924A08C736DB" modified="2016-09-07" version="1">MEVLQAKDLKKIYGSGNNAVHALDGVDLSVKKGEFVAIVGTSGSGKSTLLHMLGGLDRPTSGTVIVDGQDIFSLKEEALTIFRRRKIGFVFQSYNLVPVLNVYENIILPTELDGGKVNKAFVQQIVQTLGLSDRLDALPNQLSGGQQQRVAIARALAAAPAIILADEPTGNLDSKTSQDVLSLLKVTSQKFAQTIVMITHNEEIAQMADRIIRIEDGRIVSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GGJ5</accession>
    <name>A0A174GGJ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized oxidoreductase SAV2478</fullName>
            <ecNumber evidence="3">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61684">
        <property type="protein sequence ID" value="CUO61684"/>
        <property type="gene ID" value="ERS852478_03352"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO61684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="296" mass="31928" checksum="03FDB402439F0C2D" modified="2016-09-07" version="1">MQTVIQESGNTTGTYSCGKKKKWNEVSNNMESKQKRTALVTGGSSGIGRCTAVALSKAGYIVYEFSRRDVPVEGVRHMCVDVTDEASVQEAVGKILLERGSIEILVNCAGFGISGAVEFTESEQAKAQFNVNFFGTVNVSRAVLPSMRRQHRGHIVNISSVAAVAHIPFQAFYSASKAAVSSYSCALDNEVSPYGVRVTAVELGDIHTGFTQARQKTVLGDDEYGGRISHSVSQMEKDELSGMSPEVIGTYIARLAQKKNCAPICVAGVKYKILRLLCKILPCTLRGKIVGSIYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GKH5</accession>
    <name>A0A174GKH5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA carboxyltransferase 12S subunit</fullName>
            <ecNumber evidence="3">2.1.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.3.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059404.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63132">
        <property type="protein sequence ID" value="CUO63132"/>
        <property type="gene ID" value="ERS852478_03396"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047154">
        <property type="term" value="F:methylmalonyl-CoA carboxytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="231"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO63132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="478" mass="50640" checksum="9C3E86AC2E63882C" modified="2016-09-07" version="1">MSNATQSLAGTRITSLLDANSFVEIGQGVTARSTDFNMTANKAPSDGVITGYGVIDDKLVYVYSQDASVLNGTVGEMHAKKITRLYDLAMKTGAPVIGLVDCAGIRLQEATDALEAFGQIYLKQTLASGVIPQITAIFGTCGGGMAVIPSLTDFTFMESKKGKMFVNTPNALEGNNTDKCDTAAADFQSKETGVIDGVGTEDEILGQIRSLVSLLPSNNEDTDNYTECTDDLNRVCADLANCAGDTAIALSQIADNGEFFETKADYAKDMVTGFIRLNGATVGAVANRSEVYDAEGKKVETFDGSISARGARKAADFVKFCDAFDIPVLTLTNATGFMATLCSEKMMAKSVGELVAAFADATVPKVNVIIGKAYGTAYVAMNSKSIGADLVYAWDNAEIGMMDASLAAKIMYADADAAELNEKAAQYRELQNGVASAAARGYVDTVISPADTRKYVIGAFEMLFTKREDRPSKKHGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GLA4</accession>
    <name>A0A174GLA4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptide deformylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61730">
        <property type="protein sequence ID" value="CUO61730"/>
        <property type="gene ID" value="ERS852478_03354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO61730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="59" mass="6863" checksum="F65BC5556B64043B" modified="2016-09-07" version="1">MVKNIMRDPLFLSQKSEAATKEDLQIGGDLMDTFVRNSYMGSFSGNDVYWEKPFFDYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GPS6</accession>
    <name>A0A174GPS6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">cmk</name>
        <name evidence="10" type="ORF">ERS852478_03390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO62940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201362.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62940">
        <property type="protein sequence ID" value="CUO62940"/>
        <property type="gene ID" value="ERS852478_03390"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="5"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="9"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO62940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="223" mass="24563" checksum="3E6DE82497E0052A" modified="2016-09-07" version="1">MGCNIAIDGPAGAGKSTIAKKVAKELSFIYVDTGAMYRAMALYLLNHGVNGENQEEIEAVCSGADISIEYKNGEQIVILNGENVNAMIRTEQVGNMASKSSANPKVRAHLLKLQRTLAEKNDVVMDGRDIGTTILPNAEVKIYLTASADTRAKRRALEYEQKGESFDLDQIRKDIIERDERDMNREISPLKQADDAVLVDSSEMGIDDVVNAILNVYKEKVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GQW3</accession>
    <name>A0A174GQW3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="4">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">dacB_8</name>
        <name evidence="17" type="ORF">ERS852478_03407</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201384.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63406">
        <property type="protein sequence ID" value="CUO63406"/>
        <property type="gene ID" value="ERS852478_03407"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015956">
        <property type="entry name" value="Peniciliin-bd_prot_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012907">
        <property type="entry name" value="Peptidase_S11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037167">
        <property type="entry name" value="Peptidase_S11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07943">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00936">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69189">
        <property type="entry name" value="SSF69189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022740" description="Serine-type D-Ala-D-Ala carboxypeptidase" evidence="15">
        <location>
            <begin position="26"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="PBP5_C" evidence="16">
        <location>
            <begin position="292"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="12">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUO63406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="399" mass="44311" checksum="63B4DD54BAAA9169" modified="2016-09-07" version="1">MRKKWISIICAVIIMVCTIITPAYAAGIFLPEEINTRQAESTDLIEAPSGILMEAQTGTVVYQKDADTRRSPASITKIMTLILIFDALDKGSLKMDDTVTTSAHAKSMGGSQVFLEEGEIQTVETLIKCIVIASGNDASVAMAEHICGSEQEFVRHMNERAEGLGMKNTHFEDCCGLTESPDHYTTARDIAIMSRELITKYPKILEYSSIWMENITHVTRQGTKEFGLTNTNKLIRSYEGCVGLKTGSTSIAKYCLSAVAKRNDITLIAVVMAAPDYKVRFKDAASMLNYGFSKCSLYIDKKMEALPEIPVRNGKKKTVSLVYEEQFHYLDTTGQNIGNVKRKLRIHREVKAPVKKNTLAGEMIYSVDGKELGRVRILYGENAGKATYLDCLKKVVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GVX0</accession>
    <name>A0A174GVX0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inner membrane protein YjjP</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Threonine/serine exporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yjjP</name>
        <name evidence="3" type="ORF">ERS852478_03455</name>
        <name evidence="4" type="ORF">GT712_16655</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO64990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053850.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000136.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64990">
        <property type="protein sequence ID" value="CUO64990"/>
        <property type="gene ID" value="ERS852478_03455"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="2">
        <location>
            <begin position="10"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO64990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="254" mass="27838" checksum="AF268BD964137EE5" modified="2016-09-07" version="1">MQTSKDFLHIFLDMGDALLNSGAEIFRVEDTLNRMGYACGAAQMNVFVITSSIVITMEFPEEGARTQTRRIRESGGNDFTKLEQLNDLSRRFCNHPVPAAELRKEFDKININKTKPLWKLLGSLLAACSFAFFYGGSIPDAVAAGFGAVLIWGLQQYLRPVCMNEVTFQFVASFFTGCAICGLTLLCPFLRMDKIMIGDIMLLIPGLMSTNAIRDVLIGDTLSGIIRLIAALLLAAALALGFMGAIILFGRFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H2J2</accession>
    <name>A0A174H2J2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201455.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69124">
        <property type="protein sequence ID" value="CUO69124"/>
        <property type="gene ID" value="ERS852478_03591"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030HC0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO69124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="85" mass="9691" checksum="D3555BD5FFD3156E" modified="2016-09-07" version="1">MEKETMGTVISVTKQWWLKVNRKPARVHAMDGAAFPHTIKVKYTIDGKDYICRKWIGAGNKVPDKGTTIKVIYCEDKPSKARIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H2R4</accession>
    <name>A0A174H2R4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_01604</name>
        <name evidence="1" type="ORF">ERS852478_03544</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67606">
        <property type="protein sequence ID" value="CUO67606"/>
        <property type="gene ID" value="ERS852478_03544"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO67606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX64750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="78" mass="8938" checksum="5C0A17ED8C40EA01" modified="2016-09-07" version="1">MQELRNTKIIAVDHGYGNMKTANTVTPTGIKAYETEPIFTGNILEYNGIYYRIGKGHKEFIPDKAMDEEYYLLTLMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H2T4</accession>
    <name>A0A174H2T4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_03534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201419.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67349">
        <property type="protein sequence ID" value="CUO67349"/>
        <property type="gene ID" value="ERS852478_03534"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO67349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="305" mass="35294" checksum="D2653229999F3C32" modified="2016-09-07" version="1">MKTDRLIGILSILLQEEKTTAPELAEKFEVSRRTINRDIEDLCKAGIPIRTAQGTGGGISIMDGYRMDRTILTSKDMQMILAGLRSLDSVSGNRYYGQLMEKIQTGSSEFISERDFMLIDLSSWYKGSLVPKIEVIQNAIENRHTIQFKYYAPSGDSNRRIEPYYLVFRWSSWYVWGWCLEREDYRLFKLNRMDCVTESEQFFMCRNVPMPNLSNEKIFPGGIKVKVLFAPDVKWRLVEEFGPHCFTRTDDGRLLFSADYTDMENLVTWLMTFGAKAEVLEPKEARDIIRRNAEETLKSYGGLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H3Z4</accession>
    <name>A0A174H3Z4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201431.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68056">
        <property type="protein sequence ID" value="CUO68056"/>
        <property type="gene ID" value="ERS852478_03557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO68056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="168" mass="19616" checksum="8D271A062B3A2561" modified="2016-09-07" version="1">MIKNKYFHGAKISSYGVSEVFLDYQCMAEMAQAEFIDIYSEEYEDACWELYNGEDCYYYDSDGHTYDYEGCIERIEELKDMIANARGEQDVSKWEKDIDSLTYNCECIGICDYMEITEEAARIMKESGSDEIVYYSKELDMYIWGITHYGTSWKLMLTSIPIPEDNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H905</accession>
    <name>A0A174H905_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">M18 family aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">apeB</name>
        <name evidence="11" type="ORF">ERS852478_03645</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381444.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70751">
        <property type="protein sequence ID" value="CUO70751"/>
        <property type="gene ID" value="ERS852478_03645"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO70751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="422" mass="47322" checksum="2D110D4D23B6260B" modified="2016-09-07" version="1">MYRKTAKKLLKFIEKSPTAFQAVTEMTKRLDKEGFEELKEEDHWKLKKGGNYYVTRNHSAIIAFSIPQKPVWKFHIMASHSDSPSLKIKENPEIEVENAYIKLNVERYGGMILSPWFDRPLSVAGRLIVCQNGKIREKMVAVDRDLLVIPNLAIHMNREVNDGYKYNVQKDMLPLFSDKEGKGRFMETVAEAAEVKTEDILGHDLFLYDRTPGTLWGVNEEFVSAPRLDDLQCAFSSMEGFLQGNREESISVHCVLDNEEVGSSTRQGAASAFLKDTLMRINMGLGRTQEEYYMALADSFMISADNAHALHPNYTDKTDPVNRPVLNGGIVIKYNANQKYCTDGVSAAIFKDICDRAKVPYQTFVNRSDMAGGSTLGNISNTQVPVKTVDIGLAQLAMHSVYETTGAKDTESLVKAATVFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HDY2</accession>
    <name>A0A174HDY2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">phoR_13</name>
        <name evidence="9" type="ORF">ERS852478_03728</name>
        <name evidence="11" type="ORF">GT712_18495</name>
        <name evidence="10" type="ORF">GT728_02335</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">BIOML-A1</strain>
            <strain evidence="11 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000045">
        <property type="protein sequence ID" value="CUO73103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000061">
        <property type="protein sequence ID" value="MZS90979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703821.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73103">
        <property type="protein sequence ID" value="CUO73103"/>
        <property type="gene ID" value="ERS852478_03728"/>
    </dbReference>
    <dbReference type="GeneID" id="66495306"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="146"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO73103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL32069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS90979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="361" mass="41542" checksum="1BEC1C71FB22518D" modified="2016-09-07" version="1">MKLNKKEKNYLLSTLFKGYVIQCAICSVLIFGGTFLLGIMAEEILRKYVLYYYLYYRTVYLYIVAVIVWGGCIIYMTYLLLKKVVAYVYEVQAATGKMFDQNVSYIEMSPELSEIAANINQLKQEAESNARLAKENEQRKNDLIMYLAHDLKTPLSSVIGYLTLLRDESQISKELREKYLSITLGKAERLEDLINEFFEITRFNIYDITLQYTKINLTRLLEQLVYEFKPMLKSKNLQCNLCVDDDIMLRCDADKIQRVFDNLLRNAVIYSFENTDITISAQCQEDTVSIIFCNHGDTLPEEKLNRIFEQFYRLDAARSTSSGGAGLGLAIAKQIVELHNGTIVAESQEDQNKFSITLPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HFH0</accession>
    <name>A0A174HFH0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03724</name>
        <name evidence="3" type="ORF">GT712_18515</name>
        <name evidence="2" type="ORF">GT728_02355</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 5 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A1</strain>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000045">
        <property type="protein sequence ID" value="CUO73011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000061">
        <property type="protein sequence ID" value="MZS90983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012744284.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73011">
        <property type="protein sequence ID" value="CUO73011"/>
        <property type="gene ID" value="ERS852478_03724"/>
    </dbReference>
    <dbReference type="GeneID" id="66495310"/>
    <dbReference type="eggNOG" id="ENOG5033C02">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO73011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL32073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="68" mass="7439" checksum="91BF7563D7F789E4" modified="2016-09-07" version="1">MNDYDANGKKIGHSSPSFFGGMNHYDNNGHKVGESRPGFFGGLNHYDDKGHKRGHSNPGFLGGFNHYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HGP6</accession>
    <name>A0A174HGP6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannose-1-phosphate guanylyltransferase rfbM</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rfbM</name>
        <name evidence="3" type="ORF">ERS852478_03708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000044">
        <property type="protein sequence ID" value="CUO72536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201498.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72536">
        <property type="protein sequence ID" value="CUO72536"/>
        <property type="gene ID" value="ERS852478_03708"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="2">
        <location>
            <begin position="295"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO72536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="438" mass="49049" checksum="938658087C1C20FF" modified="2016-09-07" version="1">MNIILLSGGSGKRLWPLSNDIRSKQFIKIFKKEDGTYESMVQRVYRQIKKVDTDATVTIATGKTQVSAIHNQLGEDVGISVEPCRRDTFPAIALATAYLVDVMHVAPSESVVVCPVDPYVEDGYFEALKELSEQADKCEANLVLMGIEPTYPSEKYGYIIPESTDHVAEVRTFREKPTADVAEQYIAQGALWNGGVFAYKLGYVMDKAHELMDFTDYQDLFDKYDTMKKISFDYAVAEHESKIQVVRFAGMWKDLGTWNTLTEAMDESIIGKGELNDKCSGVHIINEMDVPVLAMGLHDVVISASPEGILVSDKEQSSYIKPFVDKFEQQIMFAEKSWGSFKVIDVETTSLTIKVTLNPGHSMNYHSHKNRDEVWVVISGEGKTIVDGMEQMVKPGDVITMSAGCRHTVTADTELKLIEVQLGADINVHDKQKFELER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HJI0</accession>
    <name>A0A174HJI0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">phoP_5</name>
        <name evidence="12" type="synonym">vanR</name>
        <name evidence="11" type="ORF">ERS852478_03727</name>
        <name evidence="12" type="ORF">GT712_18500</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000045">
        <property type="protein sequence ID" value="CUO73075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000061">
        <property type="protein sequence ID" value="MZS90980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004853366.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000077.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73075">
        <property type="protein sequence ID" value="CUO73075"/>
        <property type="gene ID" value="ERS852478_03727"/>
    </dbReference>
    <dbReference type="GeneID" id="42700405"/>
    <dbReference type="GeneID" id="66495307"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="134"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="134"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO73075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS90980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="233" mass="27166" checksum="7F958499B48D2BB8" modified="2016-09-07" version="1">MNKKILIVDDEKEIVDLLEVYLSNDGYSVYKCYNGLEAMKCIKQSQIDLAILDIMLPDIDGFRLCQKIREKFYFPIIMLTAKIEDSDKIMGLTIGADDYITKPFNPLEVVARVKTQLRRYQSYNSPNLSQSEEKDEYDIRGLLINRVSHKCYLYGKEIALTPLEFSILWYLCEHQGKVVASEELFEAVWKEKYLRNSNNTVMAHIGRLREKLNEPSKNPKFIKTVWGVGYEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HQL6</accession>
    <name>A0A174HQL6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase 2</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">adhB</name>
        <name evidence="3" type="ORF">ERS852478_03798</name>
        <name evidence="4" type="ORF">GT712_14670</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000050">
        <property type="protein sequence ID" value="CUO75165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000033">
        <property type="protein sequence ID" value="MZS90280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201531.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75165">
        <property type="protein sequence ID" value="CUO75165"/>
        <property type="gene ID" value="ERS852478_03798"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="32"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO75165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="411" mass="45346" checksum="C923BE57F002CD3B" modified="2016-09-07" version="1">MNTLRKIYCRAFQKAFHIAIPFLPYRKPKIAGSVKELPEIIMRHKCTHVLIITDGGIMKLGLTRRLEKALKEAGIPYTIYDKTVANPTTVNVREALELYHKEGCDAIIGFGGGSSMDCAKAVGACAVKPNQSLAQMKGILKVHKKLPLLMAVPTTAGTGSETTLAAVITDADTRYKYAINDFPLIPRYAVLDPKVTLSLPPFITATTGMDALTHAVEAYIGNSTTIDTRRDALKAVKLIFENIDIAYEHGDNIHARRNMLHASFYAGCAFTKSYVGYVHAVAHSLGGQYNVPHGLANAILLPLVLREYGSCIDKKLHRLAIAAGLADKNTPDHEAAELFIRAIEEMKERFGIVNIVKEIQETDIPKLAHYADKEANPLYPVPKLMDASELEKFYYMLMSLTSKENTSEAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J809</accession>
    <name>A0A174J809_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 8" type="primary">rpsO</name>
        <name evidence="11" type="ORF">BWLFYP14_00438</name>
        <name evidence="7" type="ORF">ERS852478_02018</name>
        <name evidence="8" type="ORF">ERS852523_00063</name>
        <name evidence="10" type="ORF">GT712_10215</name>
        <name evidence="9" type="ORF">GT728_08840</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="3 6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO95812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000018">
        <property type="protein sequence ID" value="MZS89432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707580.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2229"/>
    <dbReference type="EnsemblBacteria" id="CUO16351">
        <property type="protein sequence ID" value="CUO16351"/>
        <property type="gene ID" value="ERS852478_02018"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95812">
        <property type="protein sequence ID" value="CUO95812"/>
        <property type="gene ID" value="ERS852523_00063"/>
    </dbReference>
    <dbReference type="GeneID" id="66495638"/>
    <dbReference type="eggNOG" id="COG0184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO16351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO95812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS89432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX62358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="88" mass="10140" checksum="B7A9B770B1EB15C9" modified="2016-09-07" version="1">MISKEKKAAIMKEYARTEGDTGSPEVQVAVLTARIQELTEHLQSNHKDHHSRRGLLKMVGQRRGLLAYLKKTDIERYRALIEKLGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JGL7</accession>
    <name>A0A174JGL7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="8">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">glyQS</name>
        <name evidence="12" type="ORF">BWLFYP14_00422</name>
        <name evidence="10" type="ORF">ERS852478_02002</name>
        <name evidence="11" type="ORF">ERS852523_00080</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">2789STDY5834863</strain>
            <strain evidence="11 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO96270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380971.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2246"/>
    <dbReference type="EnsemblBacteria" id="CUO15807">
        <property type="protein sequence ID" value="CUO15807"/>
        <property type="gene ID" value="ERS852478_02002"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96270">
        <property type="protein sequence ID" value="CUO96270"/>
        <property type="gene ID" value="ERS852523_00080"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="154"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="221"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="330"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="206"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="216"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="290"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="334"/>
            <end position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO15807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO96270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX62326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="464" mass="53925" checksum="FA222A289116B118" modified="2016-09-07" version="1">MEKTMDKIIALAKARGFVYPGSEIYGGLANTWDYGNLGVELKNNVKRAWWQKFIQESPYNVGVDCAILMNPQTWVASGHLGSFSDPLMDCKECHERFRADKIIEDFSQENGIELESSVDGWSQEEMMNFIKDHNVPCPTCGKHNFTDIRQFNLMFKTFQGVTEDAKNTVYLRPETAQGIFVNFKNVQRTSRKKIPFGIGQIGKSFRNEITPGNFTFRTREFEQMELEFFCEPDTDLEWFAYWKNFCLNWLHSLGLKDEEVRYRDHDAEELSFYSKATTDVEFLFPFGWGELWGIADRTDYDLTQHQNVSGQDLTYFDDEKKQKYIPYVIEPSLGADRVVLAFLCSAYDEEVLDAEKNDVRTVLHFHPALAPVKIGVLPLSKKLNEGAEKIYQQLSKKYNCEYDDRGNIGKRYRRQDEIGTPFCVTYDFESENDGAVTIRDRDTMEQVRVKIDELDAYFADKFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JMV5</accession>
    <name>A0A174JMV5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase 2</fullName>
            <ecNumber evidence="3">3.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lip2_1</name>
        <name evidence="2" type="synonym">lip2_2</name>
        <name evidence="2" type="ORF">ERS852478_02567</name>
        <name evidence="3" type="ORF">ERS852523_00165</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000002">
        <property type="protein sequence ID" value="CUO99157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380779.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000003_gene1581"/>
    <dbReference type="EnsemblBacteria" id="CUO35647">
        <property type="protein sequence ID" value="CUO35647"/>
        <property type="gene ID" value="ERS852478_02567"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99157">
        <property type="protein sequence ID" value="CUO99157"/>
        <property type="gene ID" value="ERS852523_00165"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="81"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO35647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO99157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="316" mass="36168" checksum="93CBECC1657BC5E5" modified="2016-09-07" version="1">MINQTAKKILKALSFDGVEVEAFRHMADLKRLDPMKIFYKKIDEKIYNGSHAVPIRIFFPTEKSFRESEEKKHNIQDKKMLLFIHGGGWVTESIDNYERICARLANATGQYVVAVEYRLAPEDKFPAGLEDCYAVAKTLYSGDFMLNIKPENITLIGDSAGGNLCAALSLMARDCGEFMPKRQILIYPATYNDYTENSPFPSVRENGTDYLLTAGKMQDYIDLYARNKEDKKNPYFAPYIAEDLANQPDTLILTCEFDPLRDEGEAYGKRLKEAGNYVEIHRIKDALHGYFALGIKQLHVQESFTYINEFLKEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JSR0</accession>
    <name>A0A174JSR0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrdoorotate oxidase B, electron transfer subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Sulfide/dihydroorotate dehydrogenase-like FAD/NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrK_1</name>
        <name evidence="4" type="synonym">pyrK_3</name>
        <name evidence="4" type="ORF">ERS852478_02609</name>
        <name evidence="5" type="ORF">ERS852523_00206</name>
        <name evidence="6" type="ORF">GT728_02785</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
            <strain evidence="5 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="2">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 1 FAD per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000002">
        <property type="protein sequence ID" value="CUP00200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052424.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000003_gene1623"/>
    <dbReference type="EnsemblBacteria" id="CUO36841">
        <property type="protein sequence ID" value="CUO36841"/>
        <property type="gene ID" value="ERS852478_02609"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00200">
        <property type="protein sequence ID" value="CUP00200"/>
        <property type="gene ID" value="ERS852523_00206"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO36841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP00200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL32145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="295" mass="32322" checksum="9C6616844E3B5821" modified="2016-09-07" version="1">MYKILKAETLAAKIHLMVVHAPRVASHCQPGQFIIVKLDEKGERIPLTICDYDREEGTVTIVFQEIGVSTIKMAELKAGDAFRDFVGPLGCPSEFVEEDIEELKKKKMVFVAGGVGTAPVYPQVKWLHEHGITADVILGAKTKDMVILEKELGEVSNLYVTTDDGSYGRAGMVTKTLEDLVTNEGKHYDVCVAIGPMIMMKFVCLLTKKLGIHTIVSMNPIMVDGTGMCGACRLQVGDEIKFACVDGPEFDGHLVDFDQAMKRSQMYKTEEGRALLKLQEGDTHHGGCGHCGGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KAC5</accession>
    <name>A0A174KAC5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate starvation-induced protein 7</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Transporter substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fliY_2</name>
        <name evidence="7" type="ORF">ERS852478_01105</name>
        <name evidence="8" type="ORF">ERS852523_00427</name>
        <name evidence="9" type="ORF">GT728_00925</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
            <strain evidence="8 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP06465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380908.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000045_gene2068"/>
    <dbReference type="EnsemblBacteria" id="CUN80323">
        <property type="protein sequence ID" value="CUN80323"/>
        <property type="gene ID" value="ERS852478_01105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06465">
        <property type="protein sequence ID" value="CUP06465"/>
        <property type="gene ID" value="ERS852523_00427"/>
    </dbReference>
    <dbReference type="GeneID" id="66492937"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014251743" evidence="5">
        <location>
            <begin position="30"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="PBPb" evidence="6">
        <location>
            <begin position="33"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN80323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP06465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL31795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="298" mass="32507" checksum="D93303255A351DDD" modified="2016-09-07" version="1">MKKRSLAVLMAGVMAASMMTGVVSVYADADSKTLTVGFDAQYPPFGYKDDNGEYVGFDLDLAQEVCDNLGWELVKKPINWDSKDMELNSGSIDCIWNGFTINGREDDYTWSDPYLNNEQVMVVAADSGIEKLDDLAGKNVVVQAASAALDALNSDDNKDLTASFASLTENPDYNTAFMNLDSGAADAIAVDIGVAKYQLSQREEGKYVILDEPIQSEEYGIGFKKGNDELKDTVWEEVLKLYDAGEVDKLAEKYEVADMLCIGDDEKSDDKKDDAAEDDASDADTAKEDTADTAKDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KME6</accession>
    <name>A0A174KME6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anaerobic ribonucleoside-triphosphate reductase</fullName>
            <ecNumber evidence="6 7">1.17.4.2</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Ribonucleoside triphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nrdD_1</name>
        <name evidence="5" type="synonym">nrdD_2</name>
        <name evidence="8" type="ORF">BWLFYP14_01760</name>
        <name evidence="5" type="ORF">ERS852478_00760</name>
        <name evidence="6" type="ORF">ERS852523_00582</name>
        <name evidence="7" type="ORF">GT728_03970</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
            <strain evidence="6 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.17.4.2" evidence="6 7"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP11327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706456.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000036_gene2409"/>
    <dbReference type="EnsemblBacteria" id="CUN67137">
        <property type="protein sequence ID" value="CUN67137"/>
        <property type="gene ID" value="ERS852478_00760"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11327">
        <property type="protein sequence ID" value="CUP11327"/>
        <property type="gene ID" value="ERS852523_00582"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01675">
        <property type="entry name" value="RNR_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02487">
        <property type="entry name" value="NrdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN67137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP11327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL32374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX64946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="792" mass="90315" checksum="7086E202A0F52F22" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KYB2</accession>
    <name>A0A174KYB2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">ruvB</name>
        <name evidence="14" type="ORF">BWLFYP14_00981</name>
        <name evidence="10" type="ORF">ERS852478_01497</name>
        <name evidence="11" type="ORF">ERS852523_00782</name>
        <name evidence="13" type="ORF">GT712_13065</name>
        <name evidence="12" type="ORF">GT728_10990</name>
    </gene>
    <organism evidence="11 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">2789STDY5834863</strain>
            <strain evidence="11 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 19">BIOML-A1</strain>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP17274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000024">
        <property type="protein sequence ID" value="MZL33709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000026">
        <property type="protein sequence ID" value="MZS89976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704331.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1352"/>
    <dbReference type="EnsemblBacteria" id="CUN96110">
        <property type="protein sequence ID" value="CUN96110"/>
        <property type="gene ID" value="ERS852478_01497"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17274">
        <property type="protein sequence ID" value="CUP17274"/>
        <property type="gene ID" value="ERS852523_00782"/>
    </dbReference>
    <dbReference type="GeneID" id="66492605"/>
    <dbReference type="eggNOG" id="COG2255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 8 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="52"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN96110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP17274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL33709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS89976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX63495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="334" mass="37320" checksum="7577AF589FCE4CCB" modified="2016-09-07" version="1">MEKRIITTDVTEEDFSLEGNLRPQTLDDYIGQEKTKSTLKVYIEAAKQRHDALDHVLFYGPPGLGKTTLSGIIANEMGVHMKVTSGPAIEKPGEMAAILNNLQEGDILFVDEIHRLNRQVEEVLYPAMEDYAIDIMIGKGASARSIRLDLPKFTLVGATTRAGLLSAPLRDRFGVMHHLEFYTHEELKTIIIRSAQVLGVEIDEKGAAEIAKRSRGTPRLANRLLKRVRDFAQVKYDGRITYDVACFALNLLEVDQYGLDKIDRRILQTMIVNFQGGPVGLETLAAAIGEDSGTLEDVYEPYLLQNGFLNRTPRGRMASALAYEHLGYQMPEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L332</accession>
    <name>A0A174L332_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Succinate dehydrogenase/fumarate reductase iron-sulfur subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BWLFYP14_02544</name>
        <name evidence="9" type="ORF">ERS852478_00043</name>
        <name evidence="10" type="ORF">ERS852523_00724</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
            <strain evidence="10 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP15780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1407"/>
    <dbReference type="EnsemblBacteria" id="CUN41955">
        <property type="protein sequence ID" value="CUN41955"/>
        <property type="gene ID" value="ERS852478_00043"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15780">
        <property type="protein sequence ID" value="CUP15780"/>
        <property type="gene ID" value="ERS852523_00724"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN41955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP15780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX66172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="221" mass="25110" checksum="B47EC2A163678A3E" modified="2016-09-07" version="1">MVNVYFFGKKYSVPAELTIMTAMEYAGYTLKRGCGCRHGFCGACATIYRIKGENELKTCLACQTQVQEGMYVASIPFFPTDKRLYNIEDLKPNQQVMMELYPEIYSCIGCNACTKACTQDLNVMQYIAYAQRGELEKCAEESFDCVSCGCCSVRCPAGISHPMVGLLARRLTGKYIAPKSEHLEKRVEEIHEGKYDDLIEQIMQKPITDMQELYNNREIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LFF4</accession>
    <name>A0A174LFF4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (cytidine/uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">trmL</name>
        <name evidence="7" type="ORF">BWLFYP14_01625</name>
        <name evidence="4" type="ORF">ERS852478_01283</name>
        <name evidence="5" type="ORF">ERS852523_00875</name>
        <name evidence="6" type="ORF">GT728_08305</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">2789STDY5834863</strain>
            <strain evidence="5 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could methylate the ribose at the nucleotide 34 wobble position in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000007">
        <property type="protein sequence ID" value="CUP20330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000015">
        <property type="protein sequence ID" value="MZL33199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705660.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000052_gene881"/>
    <dbReference type="EnsemblBacteria" id="CUN87781">
        <property type="protein sequence ID" value="CUN87781"/>
        <property type="gene ID" value="ERS852478_01283"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20330">
        <property type="protein sequence ID" value="CUP20330"/>
        <property type="gene ID" value="ERS852523_00875"/>
    </dbReference>
    <dbReference type="GeneID" id="66494957"/>
    <dbReference type="eggNOG" id="COG0219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18094">
        <property type="entry name" value="SpoU-like_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029256">
        <property type="entry name" value="SpoU_TrmH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR029256-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN87781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP20330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL33199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX64770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="166" mass="18932" checksum="18CD4C9DB671FE48" modified="2016-09-07" version="1">MAKLNIVLHEPEIPANTGNIGRTCVATGTRLHLIEPLGFSLSEKALKRAGMDYWKDLDVTTYLDFEDFLEKNPGAKIYYATTKAPQTYTDVHYEEDCYIMFGKESAGIPEDILVNNQETCVRIPMIGDIRSLNLSNSVAIVLYEALRQNNFDHMNLEGHLRNYDWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M1A6</accession>
    <name>A0A174M1A6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2-iminoacetate synthase</fullName>
            <ecNumber evidence="8">4.1.99.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">thiH_2</name>
        <name evidence="9" type="synonym">thiH_1</name>
        <name evidence="9" type="ORF">BWLFYP14_01327</name>
        <name evidence="7" type="ORF">ERS852478_00957</name>
        <name evidence="8" type="ORF">ERS852523_01185</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
            <strain evidence="8 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.1.99.19" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000009">
        <property type="protein sequence ID" value="CUP30133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000090_gene2572"/>
    <dbReference type="EnsemblBacteria" id="CUN74301">
        <property type="protein sequence ID" value="CUN74301"/>
        <property type="gene ID" value="ERS852478_00957"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP30133">
        <property type="protein sequence ID" value="CUP30133"/>
        <property type="gene ID" value="ERS852523_01185"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036355">
        <property type="term" value="F:2-iminoacetate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012726">
        <property type="entry name" value="ThiH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034428">
        <property type="entry name" value="ThiH/NoCL/HydG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43583">
        <property type="entry name" value="PTHR43583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43583:SF1">
        <property type="entry name" value="PTHR43583:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00301">
        <property type="entry name" value="2-iminoacetate_synthase_(ThiH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02351">
        <property type="entry name" value="thiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="113"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN74301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP30133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX64287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="413" mass="47119" checksum="F3B4267CF1F15FF0" modified="2016-09-07" version="1">METTEKNMEHGEHFNESIVNEVILEDMKKNRIDHMKYLPGMEVLEESDVMDQVISAMNAYDYDKYTEADVRRALAHDNRTPEDFQALLSPAALPLLEEIAQAAQKETRKHFGNSVYMFTPIYIANYCENYCIYCGFNCHNKIRRAKLNAEEIDKEMAAIAKTGLQEILILTGESRAKSDVKYIGEACKIARKYFKVIGLEVYPMNSDEYAHLHECGADYVTVFQETYNSDKYETLHLAGHKRIFPYRLNAQERALKGGMRGVGFAALLGLDDFRKDAFATGYHAYLLQRKYPHAEIAFSCPRLRPIINNDRINPMDVHEPQLLQVVCAYRLFMPFASITVSTRECERVRDNLVGIAATKISAGVSTGIGSHVEDIEDKGDDQFEISDGRSVDEVYKALLDHDLQPVMNDYVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174N9T0</accession>
    <name>A0A174N9T0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyoxalase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glyoxalase-like domain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Glyoxalase-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_00069</name>
        <name evidence="2" type="ORF">ERS852478_03780</name>
        <name evidence="3" type="ORF">ERS852523_01676</name>
        <name evidence="4" type="ORF">GT728_01670</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000049">
        <property type="protein sequence ID" value="CUO74668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP45492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL31941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993716.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000114_gene1667"/>
    <dbReference type="EnsemblBacteria" id="CUO74668">
        <property type="protein sequence ID" value="CUO74668"/>
        <property type="gene ID" value="ERS852478_03780"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP45492">
        <property type="protein sequence ID" value="CUP45492"/>
        <property type="gene ID" value="ERS852523_01676"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12681">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO74668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP45492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL31941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="122" mass="13994" checksum="72F93735E0DC8EFA" modified="2016-09-07" version="1">MLKNVLIVVDDIEKSIEFYRDLFGLQVILKNEGNVILSEGLVLQDADIWGKTLNETSTPFNNMMELYFEDFDIDGLLAKYESGKYFVRYATELTELAGGQKLVRLYDPSGNLIEVRTPFRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ND14</accession>
    <name>A0A174ND14_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8 10">Ribose transport system permease protein RbsC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rbsC_2</name>
        <name evidence="7" type="synonym">rbsC_4</name>
        <name evidence="10" type="ORF">BWLFYP14_01547</name>
        <name evidence="7" type="ORF">ERS852478_02301</name>
        <name evidence="8" type="ORF">ERS852523_01640</name>
        <name evidence="9" type="ORF">GT712_12855</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
            <strain evidence="8 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP44458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705559.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000081_gene3047"/>
    <dbReference type="EnsemblBacteria" id="CUO26277">
        <property type="protein sequence ID" value="CUO26277"/>
        <property type="gene ID" value="ERS852478_02301"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP44458">
        <property type="protein sequence ID" value="CUP44458"/>
        <property type="gene ID" value="ERS852523_01640"/>
    </dbReference>
    <dbReference type="GeneID" id="66494418"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO26277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP44458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX64693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="325" mass="34675" checksum="6F7AC384CD2B3F3F" modified="2016-09-07" version="1">MEKLKQNPIVKKLGLNRILLACILVLMFVVFKVVLGSKFPVGDSIKSTLNYVYFLGFLSLGVTFVIATGGIDFSIGPVMFCCALISGYCMTSYHVPCAAAMVICILIGFAFGVFNGWMVSYMSVPPFIISMASMNIAKGIASVFTKTQSVSWPLGSDPVNGWFRNLISYKGFPVGLVIFLAAAVICGIILYNTKPGRYILCLGSNSEAVRLSGVNTKKWRMLAYVICGVLVGIGAIFFVGAYTTVQPGYGDQYNNEAIAGCVMGGTSMVGGLASIGGTVIGVFIISLLQQGIMAFGLGKGQQMIITGLIVIVAVYVDVSARRRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NGV8</accession>
    <name>A0A174NGV8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">gyrA_2</name>
        <name evidence="8 13" type="synonym">gyrA</name>
        <name evidence="11" type="ORF">ERS852478_02212</name>
        <name evidence="12" type="ORF">ERS852523_01686</name>
        <name evidence="14" type="ORF">GT712_11265</name>
        <name evidence="13" type="ORF">GT728_11105</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">2789STDY5834863</strain>
            <strain evidence="12 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="13 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 18">BIOML-A1</strain>
            <strain evidence="14 17">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO23004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000015">
        <property type="protein sequence ID" value="CUP46137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000025">
        <property type="protein sequence ID" value="MZL33729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380443.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000021_gene1719"/>
    <dbReference type="EnsemblBacteria" id="CUO23004">
        <property type="protein sequence ID" value="CUO23004"/>
        <property type="gene ID" value="ERS852478_02212"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP46137">
        <property type="protein sequence ID" value="CUP46137"/>
        <property type="gene ID" value="ERS852523_01686"/>
    </dbReference>
    <dbReference type="GeneID" id="66493403"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="10">
        <location>
            <begin position="12"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="815"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="535"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="834"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO23004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP46137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL33729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS89634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="857" mass="96262" checksum="817E31E57125EF84" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174U126</accession>
    <name>A0A174U126_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Urease subunit beta</fullName>
            <ecNumber evidence="2">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Urea amidohydrolase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureA_2</name>
        <name evidence="2 5" type="synonym">ureB</name>
        <name evidence="7" type="ORF">BWLFYP14_03500</name>
        <name evidence="3" type="ORF">ERS852478_03284</name>
        <name evidence="4" type="ORF">ERS852523_04089</name>
        <name evidence="6" type="ORF">GT712_01230</name>
        <name evidence="5" type="ORF">GT728_13075</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 H(+) + H2O + urea = CO2 + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the urease beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO59192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000080">
        <property type="protein sequence ID" value="CUQ13330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000032">
        <property type="protein sequence ID" value="MZL34107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019163039.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000032.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000010_gene2762"/>
    <dbReference type="EnsemblBacteria" id="CUO59192">
        <property type="protein sequence ID" value="CUO59192"/>
        <property type="gene ID" value="ERS852478_03284"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ13330">
        <property type="protein sequence ID" value="CUQ13330"/>
        <property type="gene ID" value="ERS852523_04089"/>
    </dbReference>
    <dbReference type="GeneID" id="66495409"/>
    <dbReference type="eggNOG" id="COG0832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01954">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="SSF51278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO59192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUQ13330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL34107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS87745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX67225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="119" mass="13239" checksum="A9BDBE8F15BAED30" modified="2016-09-07" version="1">MKIGEIMAADREITLNEGKKTVTVTVANKGDRPVQVGSHFHFFEVNKCLSFDREKAYGYHLDIPSGTSVRFEPGEEKEVQLTEMGGRQRVFGLNDLTRAQATDDTKAASMETAKLKGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WQD3</accession>
    <name>A0A173WQD3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">L-lactate dehydrogenase</fullName>
            <shortName evidence="6">L-LDH</shortName>
            <ecNumber evidence="4 6">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 13" type="primary">ldh</name>
        <name evidence="15" type="ORF">BWLFYP14_02536</name>
        <name evidence="13" type="ORF">ERS852478_00035</name>
        <name evidence="14" type="ORF">GT712_07730</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="14 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of lactate to pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(S)-lactate + NAD(+) = H(+) + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Allosterically activated by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="4 6"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703016.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41713">
        <property type="protein sequence ID" value="CUN41713"/>
        <property type="gene ID" value="ERS852478_00035"/>
    </dbReference>
    <dbReference type="GeneID" id="66492897"/>
    <dbReference type="eggNOG" id="COG0039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6 9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="12">
        <location>
            <begin position="144"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN41713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS88961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VUX66164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="316" mass="34037" checksum="FA864FFC62F2DC41" modified="2016-09-07" version="1">MSSKITIIGAGSVGSTIAYTLSSQDIASEIVLIDINKKKAEGEVLDIIQGTCFRDPISIIAGDYEDARDSDIVIITSGIARKPGQTRLELTQTNVNILKSITPEIVKAAPNALYLIVSNPVDIMTYVFTKISGLPENQILGSGTILDSARLRCGLSEHFQIAQSNIHAYVFGEHGDTSFIPWSGAYISGVSVDEYYDLEKKLGKDIEPIDKEAMLQYVQKSGGEIISKKGATFYAVSSSVCKLCSLLVSSSESISTVSTMMHGEYGIDDVCLSTLTLVGPNGVQGKVPMRMTKAEIEQLKKSADALKEIIAQIDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WYC5</accession>
    <name>A0A173WYC5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pheromone autoinducer 2 transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yhhT</name>
        <name evidence="7" type="ORF">ERS852478_00114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381245.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44090">
        <property type="protein sequence ID" value="CUN44090"/>
        <property type="gene ID" value="ERS852478_00114"/>
    </dbReference>
    <dbReference type="GeneID" id="66495911"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN44090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="485" mass="55772" checksum="8F0BFC1F79E543FE" modified="2016-09-07" version="1">MKFRWDNRYLHWGVTAFLVIAASMLFYYGIFHMKTLIVGIKTFLGIMAPIIYGVILAYILSPLINLFEQKLIYPQLEKHNIKLQKKGKRAIRWGCVLFSMFLFWIIIYALLMMVLPQLIRSIMSIIYSFPYYIKVIEKWLNSFVEHGWKLNPEMLDMINQYSAKAQEYLTTDILPQMQDMLKNVSAGIFDILIFMKNFLIGAIVALYVLADKEKFVAKSKMMVYAILPHKWANMLIRVMRFTDKTFGGFIYGKLLDSAIIGILCYFGMLLLDLPYPILISVIIGVTNVIPFFGPYIGAIPCILLILVVDPIKGLYFAIFILLLQQFDGNILGPKILGDSTGLSSFMVIVAIMIGGGLFGVPGMIAGVPVFAVLYALIWRLINHSLNDKKMPAEEETYINIDCLDEQTGEVLPLCKEEKHKVSPEELEARKNNFFMKIWNPLSGLVITIWKYLLRILNIIWGYIKKAGIFLKNRYVELKNKREKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X2A1</accession>
    <name>A0A173X2A1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspartate/ornithine carbamoyltransferase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Knotted carbamoyltransferase YgeW</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="8">2.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ygeW</name>
        <name evidence="8" type="synonym">argF_2</name>
        <name evidence="8" type="ORF">BWLFYP14_02685</name>
        <name evidence="5" type="ORF">ERS852478_00189</name>
        <name evidence="7" type="ORF">GT712_00515</name>
        <name evidence="6" type="ORF">GT728_06050</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">BIOML-A1</strain>
            <strain evidence="7 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703264.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45999">
        <property type="protein sequence ID" value="CUN45999"/>
        <property type="gene ID" value="ERS852478_00189"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017702">
        <property type="entry name" value="Carbamoyltransferase_YgeW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03316">
        <property type="entry name" value="ygeW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="4">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="3">
        <location>
            <begin position="187"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN45999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL32780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS87610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="397" mass="44872" checksum="5D5CDACA3DF8AEFE" modified="2016-09-07" version="1">MKTLQDYIDKLNSLNFKEMYNNDFFWTWDKTDDELEAVFTVADALRFMRENNISTKVFESGLGISIFRDNSTRTRFSFASACNLLGLEVQDLDEKKSQIAHGETVRETANMVSFMADVIGIRDDMYIGKGHAYQKEFMEAVTEGNKDGILEQRPTLVNLQCDVDHPTQCMADMLHIIHEFGGVENLKGKKIAMTWAYSPSYGKPLSVPQGVIGLMTRFGMDVVLAHPEGYDVMPEVEEIAKKNAEKNGGSFTKTNDMAEAFKDADIVYPKSWAPFAAMEKRTDLYAEGDFDGIDKLEKELLAQNAQHKDWACTEELMKTTKDGKALYLHCLPADITGVSCETGEVDASVFDRYRIPLYKEASFKPYIIAAMIMLSKFENPQDILKKLEVKAAPRILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X6V7</accession>
    <name>A0A173X6V7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059494.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46816">
        <property type="protein sequence ID" value="CUN46816"/>
        <property type="gene ID" value="ERS852478_00216"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN46816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="72" mass="8309" checksum="F53AD5C68064F421" modified="2016-09-07" version="1">MSIFEYDKEEEEQKLQATYEKIGEKRGEKQGELKKAKSIAISLAQEGEPVERIARTLGETEKTIKEWLAETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X7J9</accession>
    <name>A0A173X7J9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">8-oxoguanine deaminase</fullName>
            <ecNumber evidence="6">3.5.4.32</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Putative aminohydrolase SsnA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Putative chlorohydrolase/aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ssnA</name>
        <name evidence="6" type="ORF">BWLFYP14_02696</name>
        <name evidence="3" type="ORF">ERS852478_00200</name>
        <name evidence="5" type="ORF">GT712_00460</name>
        <name evidence="4" type="ORF">GT728_05995</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">BIOML-A1</strain>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.4.32" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703281.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46358">
        <property type="protein sequence ID" value="CUN46358"/>
        <property type="gene ID" value="ERS852478_00200"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102127">
        <property type="term" value="F:8-oxoguanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017700">
        <property type="entry name" value="Aminohydrolase_SsnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03314">
        <property type="entry name" value="Se_ssnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="56"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN46358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS87599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="443" mass="48798" checksum="5D52FFDF468637E7" modified="2016-09-07" version="1">MLVIGNGRMITQDASNPFLENGAVAMDGNTIVMVGVTEEVKKVYPDAEFVDAKGGVIMPAFINAHEHIYSSFARGLSINGYNPQGFLDILDGLWWTVDRHLTLEQTKLSAYATYIDSIKNGVTTVFDHHASFGHITGSLNAIEEAAKDLGVRTCLCYEISDRDGMEKSRESVMENVNFIKHALADDSDMIAGMMGMHASFTISDETMALCNELKPEGVGYHIHVAEGIYDLHQCLKEHGKRIVDRLHDWNILGPKTLLGHCIYVNEHEMDLIKDTDTMVVHNPESNMGNACGCPPTMRMVQKGILTGLGTDGYTHDMMESWKVANVLHKHSLCDPNAAWGEVPQMLFEGNAKIANRYFKKQLGVLKEGAAADVIVIDYDPLTPMNESNINGHLMFGVNGSMVQTTVCNGKVLMKDREVLVCDEAKVMADCRQAAKELADDING</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XRZ2</accession>
    <name>A0A173XRZ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Iron import ATP-binding/permease protein IrtA</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">irtA</name>
        <name evidence="10" type="ORF">ERS852478_00392</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199597.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53188">
        <property type="protein sequence ID" value="CUN53188"/>
        <property type="gene ID" value="ERS852478_00392"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="25"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="339"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="371"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN53188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="584" mass="64294" checksum="5AAE2222ED86BB41" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y0M3</accession>
    <name>A0A173Y0M3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-threonine 3-dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.103</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tdh</name>
        <name evidence="2" type="ORF">ERS852478_00465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.103" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199648.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56278">
        <property type="protein sequence ID" value="CUN56278"/>
        <property type="gene ID" value="ERS852478_00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN56278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="341" mass="37322" checksum="CA6CB5B4712D2B4C" modified="2016-09-07" version="1">MKTILIEEPGKVVIEEHEKPVRKPGEVLLKILYGGICGSDLGTYRGTFAYASYPRVPGHEFSGEIVEIDENDRGLKPGMIVTVNPYFNDGTCYSCQRGLLNCCEHNETMGAQRDGAFSEYVSVPIERVYDGKGLPAKTLALIEPFCISWHGVSRANVKEGDKVLVVGAGTIGVLAANAAKARGAEVYIADIAKEKLDYAVDTFQLKGSILNTSKEKLEEEVQRITNGNGFDVTIEAVGLPSTFQNCIDCAAYGGRVVLIGVGKKNLDFNFTIIQKKELNIFGSRNALKKDFLELIDLVKAGKVDLEKIVTNTYKLDEADKAFKEFSENAGSMLKVVIDFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y2L9</accession>
    <name>A0A173Y2L9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Xylulose kinase</fullName>
            <ecNumber evidence="3">2.7.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xylB_2</name>
        <name evidence="3" type="ORF">ERS852478_00521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199691.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58169">
        <property type="protein sequence ID" value="CUN58169"/>
        <property type="gene ID" value="ERS852478_00521"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07778">
        <property type="entry name" value="FGGY_L-RBK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042029">
        <property type="entry name" value="L-RBK-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="16"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="277"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN58169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="534" mass="58573" checksum="C2477CA9321663FB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y574</accession>
    <name>A0A173Y574_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rdgB</name>
        <name evidence="8" type="ORF">ERS852478_00526</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58347">
        <property type="protein sequence ID" value="CUN58347"/>
        <property type="gene ID" value="ERS852478_00526"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="181"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN58347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="194" mass="21463" checksum="F8B8FACC1BD791DB" modified="2016-09-07" version="1">MKKIIFATGNQDKMREIHEILADMDVEVVSMKEAGIHADIVEDGSTFEENAVIKAKTICELTGEITLADDSGLEIDYLNKEPGIYSARYMGEDTSYHIKNASLIERLNGVPDEKRTARFVCAVAAAFPDGSVKTVRGTMEGRIGYEEKGENGFGYDPIFYLPEYGCTSAELSGEEKNKISHRGKALRAIKDELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YA35</accession>
    <name>A0A173YA35_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00611</name>
        <name evidence="4" type="ORF">GT712_08495</name>
        <name evidence="3" type="ORF">GT728_05380</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000009">
        <property type="protein sequence ID" value="MZL32651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000014">
        <property type="protein sequence ID" value="MZS89109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706136.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61002">
        <property type="protein sequence ID" value="CUN61002"/>
        <property type="gene ID" value="ERS852478_00611"/>
    </dbReference>
    <dbReference type="GeneID" id="66492508"/>
    <dbReference type="eggNOG" id="COG4856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012505">
        <property type="entry name" value="YbbR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07949">
        <property type="entry name" value="YbbR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN61002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="440" mass="48103" checksum="87C0696BFE2F4199" modified="2016-09-07" version="1">MKKRKITDNIPLKIMSVAIAVVLWLIVVNIDNPTGTNYYTLNDVELINKEYVESSDTIGKMCMPEQNQDSIKVAITATKKIRDKIKVTDISAVADLQQAVSLDTNPVMVPITVTCSVPGVSPSDIKVTPQNLSVNLDEKETQEFVVNVSRGDTKPGKDYEVGSLTASPEKVRITGPKTLINKIDKVNASIELDGNTEDFTQDVNLTIIDKNQEVLTDSEMNSLRIENNAKVTVTAKLWKIRQGVQISADYVGTPAEGYQVGAVRTVPDTISVAGSAEGLESLADNNNVITIPEDSIDISGESEDVEKKISLTNLLPDNVKLTSDSSEDVWVTVSILPAGSREFEFPTKNIEVKNKPKDLQVTFETAQIEVRIKSDNKDLDDLNNDKDIKASIDLDGKKEGSYEVPVEIVLPDGYETVEDVTTEVVISSGTAVDDSKENKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YJW9</accession>
    <name>A0A173YJW9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN63537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199743.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63537">
        <property type="protein sequence ID" value="CUN63537"/>
        <property type="gene ID" value="ERS852478_00655"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045705">
        <property type="entry name" value="DUF6061"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19537">
        <property type="entry name" value="DUF6061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN63537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="81" mass="9228" checksum="8C14B03617941749" modified="2016-09-07" version="1">MDRLISCEFNMDNACVELKFLDGSMIAIDTIAVENEVADNMYQRSELDYLIYNDPIGYADLILNGNPEIYLKTVTECKPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YKW8</accession>
    <name>A0A173YKW8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">High-affinity branched-chain amino acid transport ATP-binding protein LivF</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">LIV-I protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">livF</name>
        <name evidence="9" type="ORF">BWLFYP14_01816</name>
        <name evidence="5" type="ORF">ERS852478_00692</name>
        <name evidence="6" type="ORF">ERS852523_00652</name>
        <name evidence="8" type="ORF">GT712_03230</name>
        <name evidence="7" type="ORF">GT728_03695</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP13145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993607.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000015_gene3708"/>
    <dbReference type="EnsemblBacteria" id="CUN64771">
        <property type="protein sequence ID" value="CUN64771"/>
        <property type="gene ID" value="ERS852478_00692"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13145">
        <property type="protein sequence ID" value="CUP13145"/>
        <property type="gene ID" value="ERS852523_00652"/>
    </dbReference>
    <dbReference type="GeneID" id="66493469"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN64771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP13145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL32319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS88125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX65058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="236" mass="25820" checksum="7584DDF01C397CA1" modified="2016-09-07" version="1">MALLEVQDIQVYYGMIQALKGVSFSVNEGEVIALIGANGAGKTTTLHTVTGLLRAKSGHIIYDGQDITKVPPHKIVTMGMAHVPEGRRVFANMTVLQNLKMGAFTRSDKNEIDATIEKVYKRFPRLKERQNQTAGTLSGGEQQMLAMGRALMSQPKIILMDEPSMGLSPIFVNEIFDIIKEVSESGTTVLLVEQNAKKALSIADRAYVLETGRITLEGKASDLLHDESVQKAYLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YQP4</accession>
    <name>A0A173YQP4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">murAA</name>
        <name evidence="7 10" type="synonym">murA</name>
        <name evidence="11" type="ORF">BWLFYP14_01805</name>
        <name evidence="9" type="ORF">ERS852478_00703</name>
        <name evidence="10" type="ORF">GT712_03175</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059346.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65118">
        <property type="protein sequence ID" value="CUN65118"/>
        <property type="gene ID" value="ERS852478_00703"/>
    </dbReference>
    <dbReference type="GeneID" id="66493480"/>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetylglucosamine binding" evidence="7">
        <location>
            <begin position="121"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN65118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS88114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX65036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="427" mass="46115" checksum="4E28CB4DECE80423" modified="2016-09-07" version="1">MDEIHVTGKASLSGEIFIQGSKNAALPMIAASLMHRGLSILRGCPRISDVFCMEEILKSLGAVTWWDDHDLYLDCSCADGTEIPAVYTGRMRSSIILAGAVLARNRKCRIGYPGGCTIGKRPIDLHLMALRALGADVRENASGLDGECVRFEGQDIVFPKSSVGAAQQAILAAVLAKGVTHLYNCAKEPEVFWLCRYLKTMGALIEGEETGEITIRGVDELKGGDYRIPPDRIVAGTYLCAAAAARSKIILHDVPVEELQSFMEVYRKIGGQYQVNGGTLEVNGKNAVRPAVLVETEIYPGFPTDLQAPLMAVLTGAQGQSTIRENIFDRRFGSAFQMKKMGADISVSGNQAIIRGGKTLKGTQVQAGDLRGGAALLIAALMAEGETCVTGAGFISRGYEHICEDLRTLGCRIWQPGTEDLRIYERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YRJ3</accession>
    <name>A0A173YRJ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199784.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66514">
        <property type="protein sequence ID" value="CUN66514"/>
        <property type="gene ID" value="ERS852478_00742"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033RPG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN66514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="326" mass="37012" checksum="34D2465950C9ADD2" modified="2016-09-07" version="1">MGKRCQVCDGPIVNGRCKYCGMPYRNDMELYHLNEDRSEHYRHASAKVKKAMAENEIPLSDRNKTVPKAAKTSSARTQTIRTQNTKVQTSRIQTSGTKKTSGQSYSAQTARTYSTGKKTAKSEKKKSGKAGKIFWIIVLILMVIIGQMAENWDTIGYRIEEFIYDEFDIDLNSIFDDSSSDEVNESNENNESNESNENNWTDDWSETISAVKNGQNEQRGNPDWYMFTGENYIVRTDDTASEIGDTDASDQGYDFTIDPGEYRIVSGWEKVVLEIRSSSGKDETVKFDEADHEEKIELHAGDEVSVVSLDGQDNYLAMYQIQQYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z0U2</accession>
    <name>A0A173Z0U2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted AAA-ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199808.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69056">
        <property type="protein sequence ID" value="CUN69056"/>
        <property type="gene ID" value="ERS852478_00813"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018631">
        <property type="entry name" value="AAA-ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012547">
        <property type="entry name" value="PDDEXK_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09820">
        <property type="entry name" value="AAA-ATPase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08011">
        <property type="entry name" value="PDDEXK_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA-ATPase_like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN69056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="523" mass="61152" checksum="79D73598D709689A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z1P0</accession>
    <name>A0A173Z1P0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_00811</name>
        <name evidence="6" type="ORF">ERS852523_03004</name>
        <name evidence="7" type="ORF">GT728_12465</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">2789STDY5834863</strain>
            <strain evidence="6 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BIOML-A1</strain>
        </source>
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        <property type="gene ID" value="ERS852523_03004"/>
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    </dbReference>
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        <property type="entry name" value="Znf_CHY"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF05495">
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        <property type="match status" value="1"/>
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    </dbReference>
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            <end position="109"/>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUN68998.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUP84361.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZL33993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="127" mass="14427" checksum="EA1AAD607C16BFA6" modified="2016-09-07" version="1">MQETADKSNRLKNSLPEDNLVKQENIKIHGIGLDKAGRCTHYHTQLDIAALLCAKCRKYYACYSCHDELEDHSFVATTPEEVYPVLCGNCGRKLTLQEYKKGSCPYCHAGFNPKCSLHENIYFCCTM</sequence>
</entry>
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    <name>A0A173Z8H2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane-bound metallopeptidase</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">ERS852478_00862</name>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
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        <property type="gene ID" value="ERS852478_00862"/>
    </dbReference>
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    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
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        </location>
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        </location>
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            <begin position="29"/>
            <end position="116"/>
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            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN71478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="440" mass="47806" checksum="5AF8B8A323D7923D" modified="2016-09-07" version="1">MKKKVFSLLLAGMLTFSMGTTAYATEDAIADMQAQKQQAEAGLAQTQANIDSLQSKKQELENYLSDLNTQYEDLTNAISELSIQAGEKENELKQLHTELKKAKKALNKQYDDMKLRIQYMYENGGTSALETLLSSKDLSEFLNNAESVAKISQYDRTMLEKCENLQNTIKDQETTAEEEKAAIDQLLEERAAKQQEVQNLAASTSDNISSYVSQISASQEEAAALTAEINNADNSIAQLVQQAEEEKAAREAAQAQAEAEAAAAQEQDAEESSDDYEEDTDSYEEDSSDSQDSSETEGSEDTSEDSEDSDDEDTYEENDADFYEGDSDSNESEDTSDSQASSESSSGQGKYLGNFTLTAYCNCAQCCGTAGNLTASGTVPTAGRTVAMAGVPFGTQLLINGNVYTVEDLGTPYGHVDIYCDSHSEALSFGLQSAEVYQLN</sequence>
</entry>
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    <accession>A0A173ZH05</accession>
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        <submittedName>
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        </submittedName>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
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    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN75504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="642" mass="73800" checksum="014C9535670EA4F6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A1N6</accession>
    <name>A0A174A1N6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">recN</name>
        <name evidence="8" type="ORF">ERS852478_01170</name>
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        <name type="scientific">Blautia wexlerae</name>
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            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82582">
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        <property type="gene ID" value="ERS852478_01170"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0497">
        <property type="taxonomic scope" value="Bacteria"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="330"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN82582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="563" mass="63777" checksum="4861AD6703DDB341" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A738</accession>
    <name>A0A174A738_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gap</name>
        <name evidence="14" type="ORF">BWLFYP14_03046</name>
        <name evidence="10" type="ORF">ERS852478_01188</name>
        <name evidence="11" type="ORF">ERS852523_00508</name>
        <name evidence="13" type="ORF">GT712_03700</name>
        <name evidence="12" type="ORF">GT728_00255</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">2789STDY5834863</strain>
            <strain evidence="11 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 19">BIOML-A1</strain>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP08563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704062.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2115"/>
    <dbReference type="EnsemblBacteria" id="CUN83208">
        <property type="protein sequence ID" value="CUN83208"/>
        <property type="gene ID" value="ERS852478_01188"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08563">
        <property type="protein sequence ID" value="CUP08563"/>
        <property type="gene ID" value="ERS852523_00508"/>
    </dbReference>
    <dbReference type="GeneID" id="66494023"/>
    <dbReference type="eggNOG" id="COG0057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN83208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP08563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL31664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS88217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX66770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="339" mass="36158" checksum="6459EE904775DB56" modified="2016-09-07" version="1">MAVKVAINGFGRIGRLAFRQMFGAEGFEIVAINDLTSPKMLAHLLKYDSTQGKYALADTVTAGEDSITVDGKEIKIYAKANAAELPWGEIGVDVVLECTGFYTSKDKAQAHIDAGAKHVIISAPAGNDLKTIVYNVNHETLTKEDHIISAASCTTNCLAPMAKALNDLAAIKSGIMCTIHAYTGDQMTLDGPQRKGDLRRSRAAAVNIVPNSTGAAKAIGLVIPELNGKLIGSAQRVPTPTGSTTILTAVVEGNVTKEQINAAMKAASNESFGYNEDEIVSSDIVGMRFGSLFDATQTMVLPLENGTTEVQVVSWYDNENSYTSQMVRTIKHFGKLLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A9I7</accession>
    <name>A0A174A9I7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjP</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">L-arabinose transport system permease protein AraQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_9</name>
        <name evidence="9" type="synonym">araQ_12</name>
        <name evidence="9" type="ORF">BWLFYP14_03021</name>
        <name evidence="7" type="ORF">ERS852478_01213</name>
        <name evidence="8" type="ORF">GT728_00130</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN84206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059513.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84206">
        <property type="protein sequence ID" value="CUN84206"/>
        <property type="gene ID" value="ERS852478_01213"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN84206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL31639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="281" mass="31156" checksum="72B04CC4403986D6" modified="2016-09-07" version="1">MKSNTSGRVRSIFVHLVLIFLSFLCLFFFYILIVNATRSHADLQKGFSALPGKYFLENLKNVANDGSFPMFRGILNSVVVSSCSAALCTYFSSLTAYGLYAYDFKMKKAAFTFIMAILVMPTQVTAMGFLRLITKMGMYDSLLPLIIPSIASPAVFYFMYSYLQSSLPLSLVEAARIDGSGEFRTFNSIVLPIMKPAVAVQAIFTFVGSWNNYFVPALIIQSKSKMTVPILIATLRGADYMNFDMGKIYMMITVAIVPIIIVYLLLSKYIIAGVTLGGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AEZ5</accession>
    <name>A0A174AEZ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199995.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87162">
        <property type="protein sequence ID" value="CUN87162"/>
        <property type="gene ID" value="ERS852478_01266"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033HUE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN87162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="90" mass="10699" checksum="C3C8CCC9A894C812" modified="2016-09-07" version="1">MDEEKRSNQNYEIIESCTIGSTELVIGHNPNAPNPYVCWYCKGGSNYFWGYYTNELDDARKKLNERYQSECRMPYNQPAQKQKNGDYRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AFH2</accession>
    <name>A0A174AFH2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86649">
        <property type="protein sequence ID" value="CUN86649"/>
        <property type="gene ID" value="ERS852478_01251"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032DJQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN86649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="109" mass="12784" checksum="F7F24F9EE3D55A3C" modified="2016-09-07" version="1">MLDNFRFETFVDVHSNIFDEYLSSVIAKLSKENPEYRSIEERIEELYKEYPKVMGALDTEKPSDLSEQECKALIEVLELRNRLSDMQQEAIYFRGCYDSVGYLKKAGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AFN1</accession>
    <name>A0A174AFN1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004607528.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPB010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86709">
        <property type="protein sequence ID" value="CUN86709"/>
        <property type="gene ID" value="ERS852478_01253"/>
    </dbReference>
    <dbReference type="GeneID" id="62695350"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025378">
        <property type="entry name" value="DUF4368"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14287">
        <property type="entry name" value="DUF4368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="98"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="340"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN86709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="547" mass="62666" checksum="6BB2823269E725A1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AI69</accession>
    <name>A0A174AI69_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015522621.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87188">
        <property type="protein sequence ID" value="CUN87188"/>
        <property type="gene ID" value="ERS852478_01267"/>
    </dbReference>
    <dbReference type="GeneID" id="61431713"/>
    <dbReference type="eggNOG" id="ENOG5032U8W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN87188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="100" mass="11503" checksum="0995A3659E925B66" modified="2016-09-07" version="1">MRNLKTIEKKVRAVLEKNEDARNDDMVLYLALCNACLKDAGAMPLAEIMTQHKYLGLPSFESVSRTRRKLQARYPELAGSRPVQKMRATGEKAYRRYAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AJD8</accession>
    <name>A0A174AJD8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380393.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88019">
        <property type="protein sequence ID" value="CUN88019"/>
        <property type="gene ID" value="ERS852478_01290"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032HYI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017724" evidence="2">
        <location>
            <begin position="22"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN88019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="356" mass="40000" checksum="BF326A5EF7A7AB67" modified="2016-09-07" version="1">MKNKIKKILLLGMTAMFTAGAAGTAVISCPVWADEAEQNSETAEEPKAEDVAVEEEIADQTDDKTENTDLKTVEHPRMSVYSIRRFSIVKDGEEVFQIKQEPADYKMDFDYWEITNPYDEIATVNTENMYEMFGVLAAFDLSNGVDAANTDTGLDNTKTYFTVDFVNTVNDDTAKETQDADATATILIGNTDENGDYYACVKGYEEAVYLLSKESVNSLLELKPFNLILKIPALVNIDTLDSVDISIGKKTYTMKLDGSDYKFGKKTVKKEKFTELYQALQSIMLDSEVEETKDAADKEEVLTVTFHRNTEEAPEVTLKYFAYDDTYDSLEINGTERFLVKAEDVDALVKQIKKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AQR3</accession>
    <name>A0A174AQR3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HflC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflC</name>
        <name evidence="5" type="ORF">ERS852478_01374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">HflC and HflK could regulate a protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the band 7/mec-2 family. HflC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705809.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000049.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90844">
        <property type="protein sequence ID" value="CUN90844"/>
        <property type="gene ID" value="ERS852478_01374"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052547">
        <property type="term" value="P:regulation of peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03405">
        <property type="entry name" value="SPFH_HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010200">
        <property type="entry name" value="HflC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42911">
        <property type="entry name" value="PTHR42911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005651">
        <property type="entry name" value="HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017849" description="Protein HflC" evidence="3">
        <location>
            <begin position="22"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="21"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN90844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="288" mass="31891" checksum="C46A55DD8C9467A5" modified="2016-09-07" version="1">MKGKKIGILIGVSAVVIAVGASVTVTQQNEYKLIRQFGKVDRVISSSGISFKIPFIESTQSLPKETLLYDLAASDVITKDKKTMISDSYVLWKISDPLKFAQTLNSSVESGESRINTAVYNATKNAISSMSQDQVITSRDGELSDMVMEAIGTNMDQYGIELLKFETKQLDLPDDNKEAVYERMISERDNIAATYKAEGNSEAKVIRNKTDKEVAIQISDAKKQAEILEAEGEQEYMKILAQAYGEEDRSEFYSFVRSLDALKTSMKGEDKTVILSADSPIAQIFEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ATK4</accession>
    <name>A0A174ATK4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tripeptide aminopeptidase</fullName>
            <ecNumber evidence="3">3.4.11.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pepT</name>
        <name evidence="11" type="ORF">ERS852478_01384</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of the N-terminal residue from a tripeptide.</text>
            <dbReference type="EC" id="3.4.11.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.4" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN91239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200042.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91239">
        <property type="protein sequence ID" value="CUN91239"/>
        <property type="gene ID" value="ERS852478_01384"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045148">
        <property type="term" value="F:tripeptide aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010161">
        <property type="entry name" value="Peptidase_M20B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42994:SF1">
        <property type="entry name" value="PTHR42994:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037215">
        <property type="entry name" value="Peptidase_M20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01882">
        <property type="entry name" value="peptidase-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="M20_dimer" evidence="10">
        <location>
            <begin position="205"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN91239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="405" mass="44659" checksum="76D720B9EA8A4CA0" modified="2016-09-07" version="1">MKAYERLLSYVKVFTPSSEETGTSPSTQYQFDLARLLVQELKELGVKDADVDEHCYVYGHIPATRGYESRQKLGFIAHMDTVSDFCDHPVTPLITPNYDGKDLALGTSGRILSPKMFPHLSTLKGRTLITSDGTTILGADDKAGIAEIMTMIETLNDNTIPHGPLCIAFTPDEEIGMGPAHFDIKKFGADFAYTLDGDTEGEIQYENFNAAKAVVEFTGVNVHPGSSKNTMINAALVAMEFNSMLPSADTPRNTEDYEGFFHLYSIKGDVSHAALEYIIRDHNATTFDVRKKTMEHITKILNEKWGKGTVSLTITEQYRNMKEIIDTCMELIEHATAACKECNIPPLITPIRGGTDGAQLSFMGLPCPNLGTGGHAYHGPYEHITVEGMDIAVEVGLKIIELFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AWD3</accession>
    <name>A0A174AWD3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704647.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93111">
        <property type="protein sequence ID" value="CUN93111"/>
        <property type="gene ID" value="ERS852478_01407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN93111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="90" mass="10239" checksum="C965153CD865BF3F" modified="2016-09-07" version="1">MTKKSCRRTMDENKIHEKAVKMRKKTDEQLVHYVEDRVEKARSEGFNEGKALAKNTAKEFIVLLQQNKIPGIGAVTINKLVKVAGEHGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AY14</accession>
    <name>A0A174AY14_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200068.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93354">
        <property type="protein sequence ID" value="CUN93354"/>
        <property type="gene ID" value="ERS852478_01413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN93354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="148" mass="17013" checksum="862CFA67DEADDB2A" modified="2016-09-07" version="1">MEEKNIKITINVECSEKSSVKKEQIAGYLLRAIAGVTANNKCLITNYVCEINEKNDDKLQEKYITGKPKLTKDEKSFLDGLDPSWSYMLRNGKGQLYLARKVESMYGSNFKYLYLEGITNAKFDFVEAEGESWFIDDLRKLEVKDEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B091</accession>
    <name>A0A174B091_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94481">
        <property type="protein sequence ID" value="CUN94481"/>
        <property type="gene ID" value="ERS852478_01451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN94481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="102" mass="11772" checksum="B1F8C76A49DA88C2" modified="2016-09-07" version="1">MVDPLKYSYYLVLVTEKKKKYDITNFVEDLGWEELENELAARLSCTVKNDKTTKGRISSLSKPGCYLYLYYRYKTGTAQEAMRGRIVEWNPSAKSTIKAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B7T4</accession>
    <name>A0A174B7T4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Penicillin-binding protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pbpA_2</name>
        <name evidence="4" type="synonym">pbpA_1</name>
        <name evidence="4" type="ORF">BWLFYP14_00977</name>
        <name evidence="3" type="ORF">ERS852478_01501</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96249">
        <property type="protein sequence ID" value="CUN96249"/>
        <property type="gene ID" value="ERS852478_01501"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="170"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN96249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX63491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="483" mass="53104" checksum="757C5A00E883CF7E" modified="2016-09-07" version="1">MKKRQKRKAREISEKRRPRNREYTLVSCFFVLIFVSMIGYLIYFNYAKSDDFINSPYNTRQDTFSDRVVRGKIISADGQVLAQTNVYEDGTEERTYPYANMFAHVVGYDTNGKSGLESEANFQLLTSHEFFLNQMKNEFKNQKNTGDSVNTTLNADLQSTAYNALGDRRGAVVAIEPSTGKILVEMSRPDFDPNTISQNWDTLVNDSNDSSLLNRATNGAYPPGSTFKVVTALDYFRTKGSLEGFSYLCEGSITREDHTIRCYGGTVHGQEDFYSAFANSCNSAFAEIGTMLGGSSLKKTAEDLLFNKSLPLSSYKKSTFTLNGKSSVAEVMQTAIGQGNTLVSPMHMALITSAIANGGELMKPYLIDSVVSSDGETVKTTEPENYKRLMTTNEANILGKLMKGVVENGTASALNGRGYTVAGKTGSAEFDENGSSHSWFIGYSNVDDPDLVVAIIVENGGTGSEAAVPIAEQIFDAYYYDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BCJ2</accession>
    <name>A0A174BCJ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mutator mutT protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN98193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98193">
        <property type="protein sequence ID" value="CUN98193"/>
        <property type="gene ID" value="ERS852478_01555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN98193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="161" mass="18951" checksum="F28647E331794B0B" modified="2016-09-07" version="1">MEKWDLYNAKREKSGITVCRGEIIPKGLYHLSVSVWIVNQQGQYLLSQRHPKKQYPLYWECTGGSVLSGETSLQGAIREVKEELGILLTPGSEKLIYQSRRENVQDFYDVWLFHKDIKIEEMRLQETEVVDVQWVNPDKLFEMFRLKHLHPLITYVDQLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BI05</accession>
    <name>A0A174BI05_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF2762)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381271.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99375">
        <property type="protein sequence ID" value="CUN99375"/>
        <property type="gene ID" value="ERS852478_01562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024405">
        <property type="entry name" value="Phage_BhlA/UviB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10960">
        <property type="entry name" value="Holin_BhlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN99375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="79" mass="9305" checksum="44C3CD378D1CB182" modified="2016-09-07" version="1">METTVMNVAVSHGIWAVLAVFLLVYIVKSNEKRDEKQEEREKNYQSVIEKLTEKFEILHQVQSDLSEIKENLFGKHKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BJW0</accession>
    <name>A0A174BJW0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2,3-dihydroxybenzoate-AMP ligase</fullName>
            <ecNumber evidence="4">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dhbE</name>
        <name evidence="4" type="ORF">ERS852478_01608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.2.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057318.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00853">
        <property type="protein sequence ID" value="CUO00853"/>
        <property type="gene ID" value="ERS852478_01608"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="26"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="440"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO00853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="529" mass="58450" checksum="537386D04FEFE58E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BMT6</accession>
    <name>A0A174BMT6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057320.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01005">
        <property type="protein sequence ID" value="CUO01005"/>
        <property type="gene ID" value="ERS852478_01610"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO01005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="373" mass="42363" checksum="AEDFBDA34FB8140C" modified="2016-09-07" version="1">MSLNTIGILGCGGHIGKYATEKLLRLGFQVLGAQRNSVTYFDDYKNYSFTNIDVMDKGQLDGFVEKCDIVINCISPSHLYGKIVKDAVCKKDKIYIDPSDMSFEQEERNVTGKCVTSCGYIPGISEFLPYIVAHKQFDKIRRTVIYQGGFDGCSPGAFVDMILGAANKNLFGDSYILHGNICPLSINIKKTYETPFSKNKVIFKPLINRDTIRLQKKIGSDQQYFFCAYDNMETLRFFMKLLIEGSRYESNVAAENIKRKLYERIEQDETFGKEEVGAYLFFELIGEKSGYEKCISGKLFLKNVNRLCGNFLGEVVKEIAMSPGKVLSGLNYGFEILNPEYLEKISTELENGEYMKINEIPIKNKIAIEEFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BN49</accession>
    <name>A0A174BN49_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA-invertase hin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hin</name>
        <name evidence="9" type="ORF">ERS852478_01642</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057334.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02067">
        <property type="protein sequence ID" value="CUO02067"/>
        <property type="gene ID" value="ERS852478_01642"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="7">
        <location>
            <begin position="15"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="8">
        <location>
            <begin position="171"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="385"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4 5">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO02067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="470" mass="54387" checksum="ABF27547050B5133" modified="2016-09-07" version="1">MRNIRIGKNTSNNKKTGLYIRVSTNFQFEEGYSVGAQTEKLEKYCNYQEIDNYDLYIDGGYSGSNLNRPEMKRLIKEIQEGKVESVVVVKLDRLSRSQKDTIYLLEDVFEANDVGFISLNENFDTTTPYGKAMVGILSVFAQYERENIRERTQMGITERIKTGKWRGTKPPFGYDYNNGDDVLVPNKDAETVRKIFELYKEGYSTYALAKMFDLKGDKQVSDMLSRVTYIGKLKYNKEIVDGLHEPIVDKKLFDEVQELRKTRTRATSHKSQYLLTGLIYCGLCGAKMRYQKWSGGRVMIYCYSLDHSKPHLVKNPNCQNGKLDAAEVEDVVVSDMLKLSKEYEVIEEKSEQQNQKGFEAMNQRKSVLEGKLKSLYNLYASDTNNSVLLETIGEINKELENLNTQIEQYTLKNTRAKDMTARAKAFKSVADSWEFMSFNERQKTVREYIKKIKISNDYVEIEYNDLLTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BZC9</accession>
    <name>A0A174BZC9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO04866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009247526.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO04866">
        <property type="protein sequence ID" value="CUO04866"/>
        <property type="gene ID" value="ERS852478_01703"/>
    </dbReference>
    <dbReference type="GeneID" id="61850127"/>
    <dbReference type="GeneID" id="66882337"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO04866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="111" mass="12417" checksum="23E0D62C775402FF" modified="2016-09-07" version="1">MSAKNRDNKNRWRNITVGFRVSPEENELINRAVALSGLPKQEYCYRRCLNQDVVVQGNPRVYKALKTEFATVLAELKRIEAGKGVDDELLSVIELISIILGGLKGEDANGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CAH9</accession>
    <name>A0A174CAH9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08738">
        <property type="protein sequence ID" value="CUO08738"/>
        <property type="gene ID" value="ERS852478_01823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO08738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="82" mass="9768" checksum="0BB7377B7C8C42A3" modified="2016-09-07" version="1">MTDNCEKLRKRFENGETNMSVEYCAREDDGSIRWVQKTVLMTRMVVFDTEILAEVPMIYAIILLQDTTQRHERDEQEQARLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CBF2</accession>
    <name>A0A174CBF2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01831</name>
        <name evidence="3" type="ORF">GT728_18275</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000069">
        <property type="protein sequence ID" value="MZL35071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_044996303.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000069.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08996">
        <property type="protein sequence ID" value="CUO08996"/>
        <property type="gene ID" value="ERS852478_01831"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031G2Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO08996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL35071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="54" mass="5938" checksum="3F962E877A467F64" modified="2016-09-07" version="1">MDELKTSKIWNSKWPALILMLVGVCFMGYGISRGELAVVFTKAINICMECVGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CD49</accession>
    <name>A0A174CD49_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11094">
        <property type="protein sequence ID" value="CUO11094"/>
        <property type="gene ID" value="ERS852478_01876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO11094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="115" mass="12900" checksum="D7069BCB863D73BE" modified="2016-09-07" version="1">MMPPYKIAVYDQDENQQLLLGRDPSDDSASFGYITGVAETANGYIATDGNARILYFWSKDGTLLGKIQCSNIFGIRYPWLENMKVADDGSVMLLMTQKREDESASELIVFRLTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CSS7</accession>
    <name>A0A174CSS7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">topB_5</name>
        <name evidence="13" type="ORF">ERS852478_01971</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO14785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379889.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO14785">
        <property type="protein sequence ID" value="CUO14785"/>
        <property type="gene ID" value="ERS852478_01971"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="485"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="695"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="500"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO14785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="726" mass="82276" checksum="73B04A5E98EA45E0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CTZ0</accession>
    <name>A0A174CTZ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">rbfA</name>
        <name evidence="5" type="ORF">BWLFYP14_00442</name>
        <name evidence="2" type="ORF">ERS852478_02022</name>
        <name evidence="4" type="ORF">GT712_10195</name>
        <name evidence="3" type="ORF">GT728_08820</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000018">
        <property type="protein sequence ID" value="MZS89428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707585.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16487">
        <property type="protein sequence ID" value="CUO16487"/>
        <property type="gene ID" value="ERS852478_02022"/>
    </dbReference>
    <dbReference type="GeneID" id="66495642"/>
    <dbReference type="eggNOG" id="COG0858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO16487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX62366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="131" mass="15027" checksum="7938F62078E78A0A" modified="2016-09-07" version="1">MRKNSIKNTRINGEVQKELSTIIRNEIKDPRIHPMTSVMAVEVAPDLKTCRAYISVLGEKEAKEATIKGLNSAEGYIRRQLARNLNLRNTPEIRFILDESIEYGVNMSKLIDDVTKKDSNSHRQDEEQDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CUW3</accession>
    <name>A0A174CUW3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exopolyphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ppx</name>
        <name evidence="3" type="ORF">ERS852478_02040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200507.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16993">
        <property type="protein sequence ID" value="CUO16993"/>
        <property type="gene ID" value="ERS852478_02040"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0248">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="2">
        <location>
            <begin position="36"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="336"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO16993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="512" mass="58633" checksum="8B981EEEFABFA12E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D332</accession>
    <name>A0A174D332_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_02110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'phage' integrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19863">
        <property type="protein sequence ID" value="CUO19863"/>
        <property type="gene ID" value="ERS852478_02110"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="59"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO19863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="284" mass="33002" checksum="16145EF44961B212" modified="2016-09-07" version="1">MASIRERNGKFNVIYSYTNEKGERKQKWETYETKAEAKRRKKEIEYKKEMGSFVVRKCKTLDELITEYVALYGKENWALSTYEGNVSLINNYILPIIGDAKLSEINTRFIERYYQSLLKRRAVINPLNKTSKNELVSASTIRDINKLLRNCFEQAVKWELMEKNPCIHATVPKHKSQKRDIWTADTLMYALSVCEDERLKLAINLSFSCSLRLGELLGLTWDCVDISPEAIEENRAYVFINKESQRIRKESLNALDEVDPELLAKVLANPEMRALLNSLAKTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DG89</accession>
    <name>A0A174DG89_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200638.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24483">
        <property type="protein sequence ID" value="CUO24483"/>
        <property type="gene ID" value="ERS852478_02244"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO24483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="70" mass="7959" checksum="1C7F1FA5D7B94BDB" modified="2016-09-07" version="1">MIRLKKRDIKKALKAGGVSLADVRADIEATIDEAMNSTDPDVQANFKKYFGNKRPTPEEYIYKITKKTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DKU7</accession>
    <name>A0A174DKU7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26064">
        <property type="protein sequence ID" value="CUO26064"/>
        <property type="gene ID" value="ERS852478_02294"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO26064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="44" mass="4575" checksum="CEFEAECB4823E934" modified="2016-09-07" version="1">MITAKSSFVEEKYTAQYYSGNGCLYVSGAGGVLKGGIHDLTGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DRG5</accession>
    <name>A0A174DRG5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinate-semialdehyde dehydrogenase (Acetylating)</fullName>
            <ecNumber evidence="3">1.2.1.76</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sucD</name>
        <name evidence="3" type="ORF">ERS852478_02320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.1.76" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705584.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26859">
        <property type="protein sequence ID" value="CUO26859"/>
        <property type="gene ID" value="ERS852478_02320"/>
    </dbReference>
    <dbReference type="GeneID" id="66494437"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07121">
        <property type="entry name" value="ALDH_EutE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012408">
        <property type="entry name" value="Acetald_propionald_DH-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036410">
        <property type="entry name" value="EutE_PduP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="33"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO26859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="462" mass="49584" checksum="8FADD6A5C030B57E" modified="2016-09-07" version="1">MPINENMVQEIVQEVMAKMQIADAPTGKHGIFKEMNDAIEAAKKSQLIVKKMSMDQREKIITCIRKKIKENAEVMARMGVEETGMGNVGDKILKHHLVADKTPGTEVITTTAWSGDRGLTLIEMGPFGVIGAITPCTNPSETILCNTMGMLAGGNTVVFNPHPAAIKTSIYAINLLNEASLESGGPDNIAVTVEKPTLETSNVMMKHKDIPLIAATGGPGVVTAVLSSGKRGIGAGAGNPPALVDETADIRKAATDIVNGCTFDNNLPCIAEKEIVAVSSIVDELMHYLVTENDCYLASKEEQDKLTEVVLAGGKLNRKCVGRDARTLLSMIGVNAPANIRCIVFEGPKEHPLITTELMMPILGVVRARDFDDAVEQAVWLEHGNRHSAHIHSKNIDNITKYAKAIDTAILVKNAPSYAALGFGGEGYCTFTIASRTGEGLTCASTFTKRRRCVMADSLCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DS24</accession>
    <name>A0A174DS24_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-fuculose phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fucA</name>
        <name evidence="2" type="ORF">ERS852478_02321</name>
        <name evidence="3" type="ORF">ERS852523_01620</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.2.17" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP43899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705585.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000086_gene4002"/>
    <dbReference type="EnsemblBacteria" id="CUO26906">
        <property type="protein sequence ID" value="CUO26906"/>
        <property type="gene ID" value="ERS852478_02321"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP43899">
        <property type="protein sequence ID" value="CUP43899"/>
        <property type="gene ID" value="ERS852523_01620"/>
    </dbReference>
    <dbReference type="GeneID" id="66494438"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008738">
        <property type="term" value="F:L-fuculose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="9"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO26906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP43899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="287" mass="31872" checksum="B783B1B998DB9893" modified="2016-09-07" version="1">MVNEYEIKKQICDIGRRIYSRNMVAANDGNISVKLNDNEFLCTPTGVSKGFMTPEYICKVDREGNVIQANPGFKPSSEIKMHMRVYEKRPDVGSVVHAHPIYATSFAIAGIPLTQPIMPEAVISLGCVPIAEYGTPSTMEIPDNLEKYLPYFDAVLLENHGALTWSTDLNAAYMKMESVEFYAQLLYQSKVLGGPKEFDEKNIEKLYEIRRKFGMAGKHPANLCLNKDGKNCHNCGGACQDGEFKKFPGYQYDFVGGDSKPAENNAASDAQLVAEITKQVMAQLGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DSJ4</accession>
    <name>A0A174DSJ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavodoxin family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Iron-sulfur flavoprotein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02920</name>
        <name evidence="2" type="ORF">ERS852478_02355</name>
        <name evidence="3" type="ORF">ERS852523_01064</name>
        <name evidence="4" type="ORF">GT712_13770</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP26223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000029">
        <property type="protein sequence ID" value="MZS90111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000072">
        <property type="protein sequence ID" value="VUX66644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025576904.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1074"/>
    <dbReference type="EnsemblBacteria" id="CUO28552">
        <property type="protein sequence ID" value="CUO28552"/>
        <property type="gene ID" value="ERS852478_02355"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26223">
        <property type="protein sequence ID" value="CUP26223"/>
        <property type="gene ID" value="ERS852523_01064"/>
    </dbReference>
    <dbReference type="GeneID" id="66494243"/>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO28552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP26223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="183" mass="20805" checksum="58594EBA1CAE6028" modified="2016-09-07" version="1">MKTLIFNGSPRKNGETAYMIRTLQENLGGDFKVVNAYRADIRPCIDCRWCFDHAGCAVKDEWQEVLSYIEECDHIIMASPVYFEEVTGMLLAVMSRLQTYFSARYIRKEEPVPKKKTGAVLLTAGSIGPREKAESTAEMLLRQMSCDSLGTVYVNRTDKVPVRDREDIIQEIKDLAGRLRTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DWY9</accession>
    <name>A0A174DWY9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10 11">Chorismate synthase</fullName>
            <shortName evidence="10">CS</shortName>
            <ecNumber evidence="4 10 11">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">aroC</name>
        <name evidence="14" type="ORF">BWLFYP14_00133</name>
        <name evidence="12" type="ORF">ERS852478_02404</name>
        <name evidence="13" type="ORF">GT712_04440</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="13 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="10 11">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 11">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 10 11"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704750.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30081">
        <property type="protein sequence ID" value="CUO30081"/>
        <property type="gene ID" value="ERS852478_02404"/>
    </dbReference>
    <dbReference type="GeneID" id="66494291"/>
    <dbReference type="eggNOG" id="COG0082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 10 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0521">NADP</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="296"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO30081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS88360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX66580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="364" mass="39158" checksum="2A233AD8AE3D09DB" modified="2016-09-07" version="1">MSQSSFGNKFKVTTWGESHGKALGAVIDGCPAGLPLCEEDIQKFLDRRKPGQSRYTTARKEGDLVEILSGVFEGKTTGTPISLMVRNTDQRSRDYGNIAYSYRPGHADYTFDQKYGFRDYRGGGRSSGRETIGRVAAGAIASKILEELGISICTYTRSIGPVEIASFNKEEIHQNAFYMPDAQAAVKAGEYLEECMKNQDSAGGVIECRITGTPAGLGEPVFDKLSALLAHALMSIGAVKAVEIGDGIAVTSSNGSTDNDGFTVKDGEIIKTSNHAGGIMGGISDGSEIILRAHIKPTPSISQPQQTVTKDKEPLSLEIHGRHDPVIVPRAVVVVESMAAITLADALFVNMSSQMDKVRDFYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E2M3</accession>
    <name>A0A174E2M3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthetase [glutamine-hydrolyzing] 1</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnB_1</name>
        <name evidence="9" type="ORF">ERS852478_02455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200756.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32142">
        <property type="protein sequence ID" value="CUO32142"/>
        <property type="gene ID" value="ERS852478_02455"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="357"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO32142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="619" mass="71113" checksum="5F5CB5585D875430" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ECI5</accession>
    <name>A0A174ECI5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02563</name>
        <name evidence="3" type="ORF">ERS852523_00163</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000002">
        <property type="protein sequence ID" value="CUO99108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055149056.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000003_gene1577"/>
    <dbReference type="EnsemblBacteria" id="CUO35534">
        <property type="protein sequence ID" value="CUO35534"/>
        <property type="gene ID" value="ERS852478_02563"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99108">
        <property type="protein sequence ID" value="CUO99108"/>
        <property type="gene ID" value="ERS852523_00163"/>
    </dbReference>
    <dbReference type="GeneID" id="66494150"/>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12682">
        <property type="entry name" value="Flavodoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO35534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO99108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="156" mass="17484" checksum="1C7431FD33254265" modified="2016-09-07" version="1">MSKKLVAFFSASGTTKKVAQMIAEEAKADLFEIEPKVPYTKLDLDWMNKKSRSSVEMSDKKYRPAIMKKEMDMSSYDEILLGFPIWWYVAPTIINTFLEAYDFSGKKIVLFATSGGSGFGNTVKELQSSAPDAVITEGRLLNCGTKQEISEWVNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ECP1</accession>
    <name>A0A174ECP1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxygen-independent coproporphyrinogen-III oxidase 2</fullName>
            <ecNumber evidence="3">1.3.99.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hemZ_2</name>
        <name evidence="3" type="ORF">ERS852478_02517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.99.22" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33670">
        <property type="protein sequence ID" value="CUO33670"/>
        <property type="gene ID" value="ERS852478_02517"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023995">
        <property type="entry name" value="HemZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932:SF1">
        <property type="entry name" value="PTHR13932:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00310">
        <property type="entry name" value="oxygen-independent_coproporphy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03994">
        <property type="entry name" value="rSAM_HemZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="178"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO33670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="504" mass="57884" checksum="C259027D26C87CA4" modified="2016-09-07" version="1">MCKIGILFKNRDFEHDVYELIKAFYPEAEIHTLYENGEAEYDLRFSVERDNDSYIIKYERTENLSKQETEQKGVISADILSKENAGCGIQDAHALRKENKDNIKYALYQLLVKLTGRTLPWGNLTGIRPAKLAMGMIESGMKNTEAAREMRERYLVSPQKTALAITIANREREILKDIDYENGYSLYIGIPFCPSICLYCSFSSYPLKVWEKRTDEYVEALCREVRETALMMKGRKLDTIYIGGGTPTTLLPHQIRKLLDTVGEAFGYEGLAEFTVEAGRPDSITREKLMAIREYPVTRISVNPQTMNQETLDIIGRRHTVEQTKEAFHLARELGYDNINMDLIVGLPGEDIHMVERTLEQVRELAPDSITVHSLAVKRAARLNIFKEKYQEMSFENNQEIMDLTMKTAYEMGMGPYYLYRQKNMKGNFENVGYAKVDKAGIYNILIMEEKQPIIALGAGGSSKLVFDHGQRIERVENVKDVSNYISRIDEMIERKRTAIATWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EFE8</accession>
    <name>A0A174EFE8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3786 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Domain of uncharacterized function (DUF3786)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02577</name>
        <name evidence="3" type="ORF">GT728_02630</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380770.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36007">
        <property type="protein sequence ID" value="CUO36007"/>
        <property type="gene ID" value="ERS852478_02577"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032A20">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024264">
        <property type="entry name" value="DUF3786"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12654">
        <property type="entry name" value="DUF3786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3786" evidence="1">
        <location>
            <begin position="31"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO36007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="222" mass="25848" checksum="90B4A44C2BB26C5F" modified="2016-09-07" version="1">MAFSLNDLNYEKDSKERMPWEHYTQEFATADPKEIASRLSIPYDEEAKKLTLTFLGTQYQITWPDFEVTHTPDDKGFYPLENMIYARILTIRFLLNGVKSESSGKFKTYREMPWGEVYLRQFDGRCIKRLAFSYGNRPGDFRAIMEHISAIPVKHGDIAYEVEIFPEYKIQMILWEGDEEFPPSSQILFSDNFPVSFQAEDMAVMGDVIIGSLKAYLKCVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EMY4</accession>
    <name>A0A174EMY4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Nickel transport system permease protein NikB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nikB_3</name>
        <name evidence="8" type="synonym">nikB_1</name>
        <name evidence="8" type="ORF">BWLFYP14_00897</name>
        <name evidence="7" type="ORF">ERS852478_02634</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO37966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707781.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37966">
        <property type="protein sequence ID" value="CUO37966"/>
        <property type="gene ID" value="ERS852478_02634"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="102"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO37966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX63419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="334" mass="37586" checksum="FF6C1BD33BA1C136" modified="2016-09-07" version="1">MRQKKLVYYGKKCLIFLISVFILSVAVFYVARLAPGDPLISYYGDRTEKMSPEEREWAMGKLGLNEPISVQYVKWVKNAFHGEFGISFKYKQDVVEVIGGRIGNTLVLGGIGFIIMFAGALLLGILCAWYENRLADRILCKLGTISSCIPEFWMALVLILVFSVNLKILPSSGAYSTGNAGDIGDRVLHLIMPLTIVVMEHLWYYAYMIRNKILEEVRADYVLLAKAKGLDKKKLMFRHCVRNVMPAYLSIMAIAVPHVLGGTYVVESVFSYPGIGALSYESARYHDYNLLMLLCMMSGILVIFCNIVSQTINEQIDPRMKDEVITEKSEVVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EQH1</accession>
    <name>A0A174EQH1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin--[biotin carboxyl-carrier protein] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">birA_2</name>
        <name evidence="5" type="synonym">birA_1</name>
        <name evidence="5" type="ORF">BWLFYP14_00905</name>
        <name evidence="4" type="ORF">ERS852478_02642</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707792.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPB010000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38210">
        <property type="protein sequence ID" value="CUO38210"/>
        <property type="gene ID" value="ERS852478_02642"/>
    </dbReference>
    <dbReference type="GeneID" id="66492695"/>
    <dbReference type="eggNOG" id="COG0340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="7"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO38210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX63427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="267" mass="30042" checksum="8C1ECAC7A21041EB" modified="2016-09-07" version="1">MAHLYNEETISQAINTKWAGKTVHFAKETDSTNSWIKRLAKDGAEHGTLAVAEFQSAGRGRFDRRWEAPEGSSIMMTLLLRPEFSPQYASMLTLVMGMAVAQAAEELGFNVSIKWPNDIVISKKKICGILTEMGTNGVKINYVLIGVGINVNLKEFPEEMQDKATSLILEGGHEYDRNQVIALVMKYFEINYEKFIQTCDFTHLLDDYHRILANLNQPVRVIDGDRSFEGICRGIDEKGELLVERQNKEVVKVSAGEVSVRGLYSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EUN3</accession>
    <name>A0A174EUN3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">D-alanyl-lipoteichoic acid biosynthesis protein DltB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dltB_2</name>
        <name evidence="11" type="ORF">ERS852478_02753</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200896.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41673">
        <property type="protein sequence ID" value="CUO41673"/>
        <property type="gene ID" value="ERS852478_02753"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO41673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="462" mass="53575" checksum="FDAD3E5FE6BEDDED" modified="2016-09-07" version="1">MVFNSIFFIFCFLPVFMLIYYLVPGKLRNLLLFLGSLIFYAWGEPVYVILMLFSSIFNYYMGTELERLYYDDRKQKINLIFSIIINLAVLVFFKYYGFLLNTIGGIIGIHIPHPELSLPIGLSFYTFRNLSYLFDIYLSKVSAQRNFLTFAVYSTMFPYTSAGPIVRYTDIETQLKQRTINISKFGIGAELFVKGLAKKVLLADNLSVLYSSICGHPQMSVFTSWLGILAYTMQLYFDFSGYSDMAIGLGKMLGFDFNKNFDYPYISTSVSEFWRRWHISLGSWFRDYIYIPLGGNRVSTLKHIRNILVVWALTGLWHGASWNFVLWGVYYGLFLLLEKFVLQKYLKKIPSWLCTVYTMLVVMIGWVFFSQTDFGALGHYLGTMFGIGASGFIDKTALYYLKTGFILLLISILMCRPAPYQYFKRLVRRRPVAAVIINLILFALSIAYMVYNSYTPFLYAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F9R9</accession>
    <name>A0A174F9R9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KAP family P-loop domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201002.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46884">
        <property type="protein sequence ID" value="CUO46884"/>
        <property type="gene ID" value="ERS852478_02914"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KAP NTPase" evidence="2">
        <location>
            <begin position="67"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO46884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="634" mass="74300" checksum="8A8E5F51AD565AB2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FBJ7</accession>
    <name>A0A174FBJ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type transporter ATP-binding protein EcsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ecsA_1</name>
        <name evidence="5" type="ORF">ERS852478_02872</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379821.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45525">
        <property type="protein sequence ID" value="CUO45525"/>
        <property type="gene ID" value="ERS852478_02872"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO45525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="281" mass="31940" checksum="9EDE1A78D913BBB3" modified="2016-09-07" version="1">MLKISHLQKNYRGFSLDCSMEVQPGMITGLIGRNGSGKSTTFKALLGLIHPDGGEIEVFGKKAEELKPEDKQKLGVVFADSGFSMYLTAAGVANIMKSIYPDFDREEFLQQCRRFNLPTDKKIKEFSTGMKAKFKVLAALSHKAELLILDEPTVGLDVIARDEVLNMLREYMEENESSSILISSHISSDLESLCDDFYMIHAGKIILHEDTDVLLSDYAVLKVSEEEYEKLDQQYLIKIRKEAYGYRCLTNQKQFYMENYPDVVIENGKIDDLVVMMEEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FHV2</accession>
    <name>A0A174FHV2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pstA</name>
        <name evidence="10" type="ORF">BWLFYP14_03516</name>
        <name evidence="8" type="ORF">ERS852478_02996</name>
        <name evidence="9" type="ORF">GT712_01360</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO49743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705064.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49743">
        <property type="protein sequence ID" value="CUO49743"/>
        <property type="gene ID" value="ERS852478_02996"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="88"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO49743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS87771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX67241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="301" mass="31897" checksum="099BD06FDBE1E78E" modified="2016-09-07" version="1">MQIDTAAAIDLSKEKKQNESSFSDQMKAYIKHPGSGVLALLTLLGAVLTFALLFFLIGYILVKGVPYLSTDLFSLTYNSENLSLLPSLINTFILTVVSLVIAAPLGIFAAIYLVEYAKKGSKLVNVIRITAETLSGIPSIVYGLFGMLFFVTALHWGLSLLSGAFTLVIMILPLIMRTAEEALKSVPDSYREASFGLGAGKLRTIFTIVLPSAVPGILAGVILAIGRVIGETAALIYTAGTVAEVPKNLMGSGRTLALHMYVLSGEGLHMNQASATAVVILAFVLVINFLSGAVAKRIAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FHY7</accession>
    <name>A0A174FHY7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Aspartokinase</fullName>
            <ecNumber evidence="15">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">lysC</name>
        <name evidence="18" type="ORF">ERS852478_02963</name>
        <name evidence="19" type="ORF">ERS852523_01488</name>
        <name evidence="20" type="ORF">GT712_01810</name>
    </gene>
    <organism evidence="18 21">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 21 22" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 21">2789STDY5834863</strain>
            <strain evidence="19 22">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="20 23" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 23">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="15"/>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP39788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706282.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000028_gene200"/>
    <dbReference type="EnsemblBacteria" id="CUO48446">
        <property type="protein sequence ID" value="CUO48446"/>
        <property type="gene ID" value="ERS852478_02963"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP39788">
        <property type="protein sequence ID" value="CUP39788"/>
        <property type="gene ID" value="ERS852523_01488"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 15 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="17">
        <location>
            <begin position="262"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="17">
        <location>
            <begin position="342"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="6"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CUO48446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CUP39788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="MZS87859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="402" mass="43681" checksum="C8873DFF7DB2E356" modified="2016-09-07" version="1">MLIVKKFGGTSVANKERIFNVASRCIEEYRKGNDVVVVLSAMGKYTDELITMARDVNEKPPKREMDMLFTIGEQMSVALMAMAMDKLGVPAVSLNAFQVSMHTTSSHGNARLKRIDTERIRRELDSKKIVIVTGFQGVDKYDDYTTLGRGGSDTTAVALAAALHADACEIYTDVDGVYTADPRKVPKARKLKEITYDEMLDLATLGAGVLHNRSVEMAKKYGVPLVVRSSLNNSEGTVVKEEVTVERMLISGVALDTDAVRIAVIGLKDEPGVAFKLFDTLAKKNINVDVILQSIGRAGRKDISFTVDGNDLDDAVAVLDANQARLGFAELHSERNIAKLSIVGAGMMSNPGVAAKMFESLYNEGVNINMISTSEIRVTVLINEKDGVRAMNAVHDAFGLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FK61</accession>
    <name>A0A174FK61_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Intracellular maltogenic amylase</fullName>
            <ecNumber evidence="5">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bbmA</name>
        <name evidence="5" type="ORF">ERS852478_02990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO49338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201058.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49338">
        <property type="protein sequence ID" value="CUO49338"/>
        <property type="gene ID" value="ERS852478_02990"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02857">
        <property type="entry name" value="E_set_CDase_PDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004185">
        <property type="entry name" value="Glyco_hydro_13_lg-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02903">
        <property type="entry name" value="Alpha-amylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="4">
        <location>
            <begin position="145"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO49338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="584" mass="69470" checksum="BC5179CA821F5D88" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FQ44</accession>
    <name>A0A174FQ44_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO52323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201107.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52323">
        <property type="protein sequence ID" value="CUO52323"/>
        <property type="gene ID" value="ERS852478_03076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO52323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="154" mass="18391" checksum="506FB74F759F0CBB" modified="2016-09-07" version="1">MNNPAYDSGYLNSAKLSGRYLFKLIARNCSDCFGIIYKYMKSDYRRYMDMGNPLYLCKTPKQIMGNMGITVDLNAEISNTYDEFILEWMSDCYITLQWKYRLWSSEIIDIVKPEKLYKQYYPLHETSLTNAVTKIYEIYHLKDLYMHRSELLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FVF1</accession>
    <name>A0A174FVF1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Group II intron, maturase-specific domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO54234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54234">
        <property type="protein sequence ID" value="CUO54234"/>
        <property type="gene ID" value="ERS852478_03137"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013597">
        <property type="entry name" value="Mat_intron_G2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08388">
        <property type="entry name" value="GIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIIM" evidence="1">
        <location>
            <begin position="59"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO54234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="155" mass="18531" checksum="D12DE356796DC7F5" modified="2016-09-07" version="1">MQLEDSKSRLLQSGAYIARAKQKSGECIRLQTFDFLGFTFYCGRSRKGMPYIMPKTSSKKFRQKIRDIKVWLYANRDQPLKKLMGMLNLKLIGHYRYYGISFNGRMISNYKQQVRELLFKVLNRRSDRKSYTREGFIEMLKYYPLAMPKIYVSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G2N1</accession>
    <name>A0A174G2N1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome partitioning protein ParA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Septum formation inhibitor-activating ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">parA</name>
        <name evidence="5" type="ORF">BWLFYP14_00864</name>
        <name evidence="3" type="ORF">ERS852478_03162</name>
        <name evidence="4" type="ORF">ERS852523_03519</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000053">
        <property type="protein sequence ID" value="CUP98709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000024">
        <property type="protein sequence ID" value="VUX63384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000094_gene768"/>
    <dbReference type="EnsemblBacteria" id="CUO55110">
        <property type="protein sequence ID" value="CUO55110"/>
        <property type="gene ID" value="ERS852478_03162"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP98709">
        <property type="protein sequence ID" value="CUP98709"/>
        <property type="gene ID" value="ERS852523_03519"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043753">
        <property type="entry name" value="DUF5699"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18956">
        <property type="entry name" value="DUF5699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_31" evidence="2">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO55110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP98709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX63384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="149" mass="15992" checksum="5B8019EDC2929258" modified="2016-09-07" version="1">MPVAHVQHRPERERRSVGKTTTCANLGIGLAQAGKKVLLIDGDPQGSLTISLVLKCLLMIVTAPVIWVLTLFVWLCMGLIYISGLVLGLLSTVIALLGVAVLITYSPQNGAILLVMAFLISPMGLPLATIWLLGKVQSLKFAIQDWAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G6P6</accession>
    <name>A0A174G6P6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO58133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201253.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58133">
        <property type="protein sequence ID" value="CUO58133"/>
        <property type="gene ID" value="ERS852478_03251"/>
    </dbReference>
    <dbReference type="GeneID" id="66496161"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022295" evidence="2">
        <location>
            <begin position="33"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO58133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="213" mass="23276" checksum="29C2F3D15AC867FF" modified="2016-09-07" version="1">MRKKILKVFFVILTGITVTLTGCELSGSNESAQTESESGKDAVKFIPNLTTAVTRKPTPTAVAANPGDSVQNQQSGNNAEAEIYQSQGDPADQESAQEETYDIQYITGNILYSDENTITVEVGESGNYYNMVFNIENAVLNIANGSAVRSGLNVDLEYYSQNNVNIVIMLTSDGEEYLPSSTLEEAQKMTDEYVPDVSESENEDFEDTSPSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G8I5</accession>
    <name>A0A174G8I5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine synthetase</fullName>
            <ecNumber evidence="3">6.3.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glnA_1</name>
        <name evidence="4" type="synonym">glnA_2</name>
        <name evidence="3" type="ORF">ERS852478_03224</name>
        <name evidence="4" type="ORF">ERS852523_01229</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
            <strain evidence="4 6">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP31717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055150384.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000049_gene1310"/>
    <dbReference type="EnsemblBacteria" id="CUO57486">
        <property type="protein sequence ID" value="CUO57486"/>
        <property type="gene ID" value="ERS852478_03224"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP31717">
        <property type="protein sequence ID" value="CUP31717"/>
        <property type="gene ID" value="ERS852523_01229"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040577">
        <property type="entry name" value="Gln-synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022147">
        <property type="entry name" value="GSIII_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18318">
        <property type="entry name" value="Gln-synt_C-ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12437">
        <property type="entry name" value="GSIII_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="2">
        <location>
            <begin position="172"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO57486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP31717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="706" mass="78619" checksum="8DD39F4F4998D907" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GFK5</accession>
    <name>A0A174GFK5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO59928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201271.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000138.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59928">
        <property type="protein sequence ID" value="CUO59928"/>
        <property type="gene ID" value="ERS852478_03301"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="2">
        <location>
            <begin position="326"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO59928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="432" mass="49630" checksum="97556A4CC79A5DF3" modified="2016-09-07" version="1">MEYIILLIFSFFTEAVILWQYAASLFSPSHSGKKRLTLLSVLYVLLFFLSLLGQTWLNIISFFVINTVFLYIMFNLKLLLALFHSAILTAIMGISELAVLGMISRFFPHFLLEASVGLVFYTVFSKITFFAVVYLLSWLFKGNKAAQEPYGHSEILLMFIPLSSILMMFTLLSIGETTAYAPPVDFLVTICAVFLLLVNLLVFGINQYNTKRSQEYADLQLLLQKESDSVEYYEMMLAQNENQSILIHDIKKHLQSIRLLNEKNDSDKINDYIQQLMESSDLKETTKLCDHEMLNSILCRYQRHCNDKHIIFHTDIRSGTVQHIYPRDLTSLFCNLLENAVESAENIPDSFIELTVQKKENSPFLIIILINSCQNTPVYNPEGLPISHKSDNGRHGFGIKSIKKVVKQYHGNLQMYYDNDSGTFHTILTLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GH29</accession>
    <name>A0A174GH29_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.63</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ogt</name>
        <name evidence="2" type="ORF">ERS852478_03360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.63" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61882">
        <property type="protein sequence ID" value="CUO61882"/>
        <property type="gene ID" value="ERS852478_03360"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007351">
        <property type="entry name" value="YjbR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038056">
        <property type="entry name" value="YjbR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04237">
        <property type="entry name" value="YjbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142906">
        <property type="entry name" value="SSF142906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="117"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO61882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="223" mass="25712" checksum="6437569178BE3D7A" modified="2016-09-07" version="1">MNQNCMITREAALEFGLSFQNTYTERPFRNQNWQVVRARENKKIFLWIYERNGYVNLNVKANPEWRDFWRSAYESVQAGYHQNKEHWNTIILNGTVPDKDIKRMISESYDLVTYSPTKKIYEAVKQIPKGCVATYGQVAEMAGNPRMSRAVGNALHKNPDPEHIPCYRVVNSRGELSGAFAFGGKDVQKKLLEADGIEVVNGTVDLKKYGLTQRDDKLWKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GIW3</accession>
    <name>A0A174GIW3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsC family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_03006</name>
        <name evidence="2" type="ORF">ERS852478_03337</name>
        <name evidence="4" type="ORF">GT712_03900</name>
        <name evidence="3" type="ORF">GT728_00055</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ArsC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704002.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61317">
        <property type="protein sequence ID" value="CUO61317"/>
        <property type="gene ID" value="ERS852478_03337"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30041">
        <property type="entry name" value="PTHR30041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03960">
        <property type="entry name" value="ArsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO61317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL31624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="113" mass="13072" checksum="1C6047D5C14C23D3" modified="2016-09-07" version="1">MNIQIFGTKKNFDSKKAERYFKERGIKYQFIDMKEKGLSKGEFQSVCQAIGGYDKLIDTDCKDKDLLALITYIAEEDKAEKILENQSIIKVPVVRNGKQATVGYQPEIWKSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GQ97</accession>
    <name>A0A174GQ97_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxaloacetate decarboxylase gamma chain</fullName>
            <ecNumber evidence="5">7.2.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BWLFYP14_02975</name>
        <name evidence="7" type="ORF">ERS852478_03395</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:57724"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="EC" id="7.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the OadG family.</text>
    </comment>
    <dbReference type="EC" id="7.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000072">
        <property type="protein sequence ID" value="VUX66699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63100">
        <property type="protein sequence ID" value="CUO63100"/>
        <property type="gene ID" value="ERS852478_03395"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RW6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015451">
        <property type="term" value="F:decarboxylation-driven active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005899">
        <property type="entry name" value="Na_pump_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04277">
        <property type="entry name" value="OAD_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01195">
        <property type="entry name" value="oadG_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="5" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033253550" description="Oxaloacetate decarboxylase gamma chain" evidence="6">
        <location>
            <begin position="20"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO63100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="240" mass="25624" checksum="069B003AB71A35A7" modified="2016-09-07" version="1">MTFLVMAALVIGSTSVVFAADKVDDTVKSTLVTTAEGLTDAIVQLKDEEIENYMSSGDDFTTSAMQSWQTSKDELGAKKDSNGETTVTFKDDQYTVTVPLKFEKAEANFVYVFDSQGTPTSMSVDVQYGMGKTLQRAGLNTLMGIGTVFVMLILLSLLISLFRFIPNPEAKKAAEAKAAKAAKEAEAAAIAQTAPAQAEENLADDGELVAVIAAAIAAAEGTTTDGFVVRSIRKVKRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GQY0</accession>
    <name>A0A174GQY0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Threonine/serine exporter family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_03456</name>
        <name evidence="8" type="ORF">GT728_16180</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65014">
        <property type="protein sequence ID" value="CUO65014"/>
        <property type="gene ID" value="ERS852478_03456"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="6">
        <location>
            <begin position="8"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO65014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL34688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="148" mass="16330" checksum="AB1828432E75FEF2" modified="2016-09-07" version="1">MTAAIMIQLITGAIGSVGFGILFHIKKKYLPLAAVGGFLSWLVFLLGKEFWGNVFLPTLMAGFVTDVYAEILARICKETSTSFFVTSVIPLIPGSTLYYCMNSIVEGNTVRALEYGRDTFLFAFGIAAGMSIAWSICYFLRTVRKKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GUN0</accession>
    <name>A0A174GUN0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201415.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66314">
        <property type="protein sequence ID" value="CUO66314"/>
        <property type="gene ID" value="ERS852478_03497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO66314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="279" mass="32835" checksum="19D1BB6CFA0F9ADE" modified="2016-09-07" version="1">MKNSSERKRYKTNPNFDAYLLYSYIQMKRNASDKISRDKADKLIYEYLNNYIMYELYYSYRSTLEKCEFQELYQSLWVEVLADLPRFNPDLGRATTFFRYSIKHAVCIFVSFKKYNTTPYLANQLEKIKKIQQECEESGTPFTVELASKYLHCTIPTVLNYQVKLGMESSFSYEVISVTNKYFSYDSYDEEATDSKPISSYSDAELRKLVKDFSEKELCLLNMYLQMCTQENSYNIEEFRKAKASQSAMTKAETEQAIIKIEDLFKKIGINKALRGQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GV33</accession>
    <name>A0A174GV33_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66393">
        <property type="protein sequence ID" value="CUO66393"/>
        <property type="gene ID" value="ERS852478_03500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025359">
        <property type="entry name" value="DUF4263"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14082">
        <property type="entry name" value="DUF4263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO66393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="389" mass="43519" checksum="B0C3B6CED7EDE4EE" modified="2016-09-07" version="1">MKTTLLIMAAGIGSRFGTGIKQLEPVDYAFQDINDIPGTLPEGRTKPWGTGQAVLAAKKVIKTPFIVINADDYYGKEGFKAVHEYLVNGGKSCMAGFVLKNTLSDNGGVTRGICKMNEDYNLTEVVETKNIVKTAAGAEAEGMAVDVDSLVSMNMWGLTPDFLTTLEEGFKEFFEKEVPGNPLKAEYLIPIFIGELLEHGKISVKVLKTNDTWYGMADYLAEPHEEYICFSNYPIGDKIADFVVLTSRSKMKVCIVEVKGADFKIVKANHYQGLNVHMNDAITQLKNHMEYINRNYSSFRTQIHEDKDKAINEEYSGNYLVGPRKTLLVDPQKDIDVKYIAIGGVEREDKSIEESHEIVKCKPADNLEIASWNSFVRKLDEYHGHHPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GXR5</accession>
    <name>A0A174GXR5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA protecting protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">smf_2</name>
        <name evidence="2" type="ORF">ERS852478_03514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66751">
        <property type="protein sequence ID" value="CUO66751"/>
        <property type="gene ID" value="ERS852478_03514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO66751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="195" mass="21825" checksum="D8FA6076DA2426AA" modified="2016-09-07" version="1">MEKAKRIMDDCQNKNISILCWNDERYPLRAREPADAPPMLYYKGNIKKMDQTVGIVGARRCSQKAKQETVFLASEYAKTRIAVVSGMAKGIDSYAHTACLNAGGYTIAILGNGLDICYPSEHHKLMKCIEEKGLLLSEYPPGTPPSRYTFPRRNRLISSWSDKLIIIQAGKGSGALITAEYSRKYGRKVEMKAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GYN3</accession>
    <name>A0A174GYN3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arabinose import ATP-binding protein AraG</fullName>
            <ecNumber evidence="5">3.6.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">araG_2</name>
        <name evidence="5" type="ORF">ERS852478_03491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.17" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66158">
        <property type="protein sequence ID" value="CUO66158"/>
        <property type="gene ID" value="ERS852478_03491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO66158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="221" mass="24601" checksum="838B09E18655C1D3" modified="2016-09-07" version="1">MDKQGLVLNGIGKQFYGITVLSDIDFEILPGEIHGLLGENGAGKSTLMKIINGALTPTTGDIYIDGEKMSFDSPHAAANHGIRMVYQELDLFPHLTVAENICQGNIPKNKAGMVDWKEMERVSKELLKLIKVDINVNERMDRLSIAQQQIAAIARALNGNCKFILLDEPTSALPKKDVENLFAIVRNLKKEGISVVFISHKLDEMMDITDRITIYHFTTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H0B3</accession>
    <name>A0A174H0B3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060676.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66499">
        <property type="protein sequence ID" value="CUO66499"/>
        <property type="gene ID" value="ERS852478_03504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025427">
        <property type="entry name" value="DUF4160"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13711">
        <property type="entry name" value="DUF4160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO66499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="88" mass="10079" checksum="169BC812274FDF80" modified="2016-09-07" version="1">MPELSRFEGMVIKMLFNDTVQHNKPHVHVTYGEYKASVGIDGELLAGSLPQKQFRMLVGWLALHEEEAYAAWNKAVRGEHFDKIKPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H0Y5</accession>
    <name>A0A174H0Y5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional fucokinase/L-fucose-1-P-guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66445">
        <property type="protein sequence ID" value="CUO66445"/>
        <property type="gene ID" value="ERS852478_03502"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="2">
        <location>
            <begin position="113"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO66445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="280" mass="30741" checksum="109ADC4911524BFB" modified="2016-09-07" version="1">MNWGGGWSDTPPYCNEKGGTVLNAAILLNGEKPVEVTLERIPEQKVVFDSRDMDVHGEFDTIEPLQATGDPYDPFALQKACLLACGIIPREGHTLGEILERLGSGFVMHSEVTNVPKGSGLGTSSILSAACVKAVFEFMGIAYTEEDLYAHVLAMEQIMSTGGGWQEQVGGITYGLKYITSMPGLQQRLQVAHIELSPQTKKELDERFVLIYTGQRRLARNLLRDVVGRYVGNEPDSLFALEEIQKTAVLIDCCTIILIPVSLKCGDTGVIYRLSFLSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H3M2</accession>
    <name>A0A174H3M2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69494">
        <property type="protein sequence ID" value="CUO69494"/>
        <property type="gene ID" value="ERS852478_03606"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO69494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="36" mass="4186" checksum="A6FB1264A7460A7C" modified="2016-09-07" version="1">MEKRYTIGVMIGNANSPHTMNLMQGYKQLNINYKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H492</accession>
    <name>A0A174H492_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Superfamily II helicase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_03561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201435.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68156">
        <property type="protein sequence ID" value="CUO68156"/>
        <property type="gene ID" value="ERS852478_03561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040538">
        <property type="entry name" value="Cch_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009270">
        <property type="entry name" value="DUF927"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06048">
        <property type="entry name" value="DUF927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18662">
        <property type="entry name" value="HTH_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF927" evidence="2">
        <location>
            <begin position="296"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_56" evidence="3">
        <location>
            <begin position="705"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO68156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="816" mass="93207" checksum="63B3F0968B19D5DD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H6F9</accession>
    <name>A0A174H6F9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein, contains double-stranded beta-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03611</name>
        <name evidence="3" type="ORF">GT728_07530</name>
        <name evidence="4" type="ORF">GT728_15650</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO69771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000013">
        <property type="protein sequence ID" value="MZL33056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000045">
        <property type="protein sequence ID" value="MZL34590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004614173.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69771">
        <property type="protein sequence ID" value="CUO69771"/>
        <property type="gene ID" value="ERS852478_03611"/>
    </dbReference>
    <dbReference type="GeneID" id="61851138"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="117" mass="12731" checksum="51B804B8E9DC684A" modified="2016-09-07" version="1">MANYTKTTIGKENRIELHEKLSLTGAEISLNELPAGANVPFVHSHKENEEIYGILSGNGKAIIDGEEISLSTGDWLKIAPAAKRQFFASDISGITYICIQVKENSLEHFTAEDAVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H959</accession>
    <name>A0A174H959_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_01126</name>
        <name evidence="2" type="ORF">ERS852478_03669</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71424">
        <property type="protein sequence ID" value="CUO71424"/>
        <property type="gene ID" value="ERS852478_03669"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033ICN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033732012" evidence="1">
        <location>
            <begin position="27"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX63768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="125" mass="13983" checksum="4485958CB4FE4682" modified="2016-09-07" version="1">MNKKCLFAVVIVLVSLICLSACGALRDTADKNKALNESLPYYELNAANYDEISYNGLTYTITDECLEMSELQEEIGQVSKRFKNVAGEDFSFGYVYSIVDVDISNAVAVNINNEYRKADIKNNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HBH7</accession>
    <name>A0A174HBH7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">Int-Tn_10</name>
        <name evidence="8" type="ORF">ERS852478_03701</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO72233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579823.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72233">
        <property type="protein sequence ID" value="CUO72233"/>
        <property type="gene ID" value="ERS852478_03701"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008907">
        <property type="term" value="F:integrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075713">
        <property type="term" value="P:establishment of integrated proviral latency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044826">
        <property type="term" value="P:viral genome integration into host DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004191">
        <property type="entry name" value="Integrase_Tn916-type_DNA-bd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02920">
        <property type="entry name" value="Integrase_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="SSF54171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0229">DNA integration</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1179">Viral genome integration</keyword>
    <keyword evidence="4" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="7">
        <location>
            <begin position="82"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="187"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO72233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="399" mass="46597" checksum="43B871468921C0B6" modified="2016-09-07" version="1">MSEKRRDHRGRILHNGEIQLSDGRYRFKYVDEMGKERCVYSWRLDHNDATPKGKRRTLSLREMEKKIQADHFEQIATNGGNMTVLELVEKYTSTKTGVRPTTVAGYGTVSNLLKKDPFGKRRIDTVRISDAKCWLIHLQQVEKKSYSSIHSIRGVLRPAFQLAVDDDLIRKNSFQFQLMEVVVNDSVTREAISRAEERKFLRFVKEDPHFCRYYEGIYILFKTGLRISEFCGLTISDIDFKEHTINIDHQLQKKSKIGYYIQETKTTSGTRKIPMTADVEECFRKIIEKRNPPKAEPMVDGKSGFLYFDKNESICYSLHWEHYFQHIIQKYNNTYKVQMPVITPHVCRHTYCSNMAKSGMNPKALQYLMGHSDISVTLNTYTHVNLEDAREEVARIQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HDP4</accession>
    <name>A0A174HDP4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein conserved in archaea</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_03662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201477.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000077.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71288">
        <property type="protein sequence ID" value="CUO71288"/>
        <property type="gene ID" value="ERS852478_03662"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025831">
        <property type="entry name" value="RecG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038475">
        <property type="entry name" value="RecG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13749">
        <property type="entry name" value="HATPase_c_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlbA_2" evidence="1">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_4" evidence="3">
        <location>
            <begin position="298"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_11" evidence="2">
        <location>
            <begin position="422"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO71288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="484" mass="54723" checksum="38080E4D1C452B2C" modified="2016-09-07" version="1">MVEDTMFSGESKNIEYKVSLPDKSEKYMKTIVAFANTQGGKLIVGVDDKTHQIVGVENDVLFQLMDGIANAVSDSCVPQIIPDIEPQTVNGKTVIVVSVEAGKNRPYYLKSKGKDNGTYIRVAGTSRQAFPEKIKELEMEGARISWDELTCVSYPVSEEATEKLCQDIEKFRKKAGMSEHSVKKEQLINWKILKQSEGQLLATNAYALLTSDYFSFSKTQCAVFKGIDRAVFLDKREFTGPIYTQIEEAVDFVLRNIRLGATIDGLVRKEKYELPPEAIREMIINAHCHRNLLDESCIQVAVYDDRLEVTSPGGLYNGLTYEEIMNGHSKIRNKGIANIFSQMGLVEAWGSGIKRILNAAEEYGLPKPKFQEFDNMFRVELFRNSFPMINEKENIGEASEKHRRSIGETSEVAWRTDLNDTQQKIIKLLSEDHQLSAVKLAEKIGVASRNIENNIKKLKEYGILIRHGSPKNGYWEIVDKDLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HE61</accession>
    <name>A0A174HE61_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000045">
        <property type="protein sequence ID" value="CUO73202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201507.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73202">
        <property type="protein sequence ID" value="CUO73202"/>
        <property type="gene ID" value="ERS852478_03732"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZA5I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008023377" evidence="1">
        <location>
            <begin position="34"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO73202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="167" mass="18898" checksum="38BB84AE4A008221" modified="2016-09-07" version="1">MKRTISKSERPYRLLLCVMISLLVIMLAGCSTSSDSDTNTRGFTDFATIEEEYLTTIESLNWPEGFTPPDALEGEDTGASFQIGYGDTRASNLWEYSWMQEWLDTYNTNSERAAKALAELEKAFDMPYMGTDRCDDATRKYLRDNIDKAKLGDPSGFTECIQANYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HET6</accession>
    <name>A0A174HET6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000046">
        <property type="protein sequence ID" value="CUO73403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73403">
        <property type="protein sequence ID" value="CUO73403"/>
        <property type="gene ID" value="ERS852478_03736"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO73403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="57" mass="6744" checksum="B934D3FA4C487204" modified="2016-09-07" version="1">MTRLGQMLMDEGMELKETDSIKKLMKNMNWTIDQAMNALEVPEDKREKYRKAIIPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HH77</accession>
    <name>A0A174HH77_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO72255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579824.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72255">
        <property type="protein sequence ID" value="CUO72255"/>
        <property type="gene ID" value="ERS852478_03702"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBQ6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026989">
        <property type="entry name" value="TnpV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14198">
        <property type="entry name" value="TnpV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO72255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="127" mass="15054" checksum="81B0523E94771993" modified="2016-09-07" version="1">MSGLKKHIYEEKNGLHYTLNGDYYLPDLKLPEEHRPIGKYGRMHREYLREVHPARLNTLTLTGELWTYLADLNEQAQKRLDTIIEQMKAAEGVTEELKSICQMEWVQRCNNIHNRAEEIVLHEMIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HJ94</accession>
    <name>A0A174HJ94_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase dacD</fullName>
            <ecNumber evidence="3">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dacD</name>
        <name evidence="3" type="ORF">ERS852478_03733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.16.4" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000045">
        <property type="protein sequence ID" value="CUO73228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73228">
        <property type="protein sequence ID" value="CUO73228"/>
        <property type="gene ID" value="ERS852478_03733"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="2">
        <location>
            <begin position="56"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO73228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="346" mass="39432" checksum="D7F7D8BE5CEC1BF9" modified="2016-09-07" version="1">MQRKRRKKKRFGVFLFLLVVCIGIGIMFVPWAMQPENFREVKNKINGFLYKEDFPDSYNAKSLILVDCSDDEIFVSKNENEPQIPASLAKLFVIEYASTLADLDSIVVADYGAISLTKPGSSVAQIKEKEYFLHNLFAAMLVPSGNDAAYVVADYCGGLLSPQAESCQERVRIFMENLNLHLQQQGYLDTVLYDPSGFDMEALTITLDLKEVVYRLLEYSWFREIVSQNTYTATLPDGSTQIWQNTNAFLDPTSEYYNENVCGIKTGSLSDDYNLIVLYQQHRRLLLVMSRNYQEGIRCSSRGLTRSKRNTGALRQYRQSSGMRFILEPESGAKHVAVCIRAIKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HJW8</accession>
    <name>A0A174HJW8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase factor sigma-70</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_03738</name>
        <name evidence="6" type="ORF">GT712_18720</name>
        <name evidence="5" type="ORF">GT728_19090</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">BIOML-A1</strain>
            <strain evidence="6 8">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000046">
        <property type="protein sequence ID" value="CUO73448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000080">
        <property type="protein sequence ID" value="MZL35220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000063">
        <property type="protein sequence ID" value="MZS91015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381094.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73448">
        <property type="protein sequence ID" value="CUO73448"/>
        <property type="gene ID" value="ERS852478_03738"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="124"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO73448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL35220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS91015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="188" mass="22315" checksum="4C5E9CE2040D1637" modified="2016-09-07" version="1">MEDTVIINLYFDRSEKAIQATEEKYSKYCFSIAWNVLYDKEDSDECVNDTWLAAWNSIPPRKPAILSAFLGKITRNLAIDCFRRKKAAKRSTEHILELCKELEEIEDVTAYSLNDEIQRKEILEILEKFLESLKKGDCDIFIRRYWYMDSISEISARHGISESRIKSSLYRSRKKLWERVKHLYGKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HNL1</accession>
    <name>A0A174HNL1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000048">
        <property type="protein sequence ID" value="CUO74465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74465">
        <property type="protein sequence ID" value="CUO74465"/>
        <property type="gene ID" value="ERS852478_03776"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO74465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="117" mass="14178" checksum="919AF62E39D6FE7E" modified="2016-09-07" version="1">MKYIPLFLYSFQWNIETSYYEQKTIWSLCSYMVRSCKGIEMLVNLINICYCAMKILPYQDEQFSEYRTKSVQEFRFELSQGIRSQIFLTNFVRNIETHIKSNVIIKALKQLIRQQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LV01</accession>
    <name>A0A174LV01_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YicC family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">YicC-like family, N-terminal region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yicC</name>
        <name evidence="7" type="ORF">BWLFYP14_02930</name>
        <name evidence="3" type="ORF">ERS852478_02345</name>
        <name evidence="4" type="ORF">ERS852523_01074</name>
        <name evidence="6" type="ORF">GT712_13820</name>
        <name evidence="5" type="ORF">GT728_07840</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP26487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000014">
        <property type="protein sequence ID" value="MZL33117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000029">
        <property type="protein sequence ID" value="MZS90121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000072">
        <property type="protein sequence ID" value="VUX66654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704536.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1064"/>
    <dbReference type="EnsemblBacteria" id="CUO28220">
        <property type="protein sequence ID" value="CUO28220"/>
        <property type="gene ID" value="ERS852478_02345"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26487">
        <property type="protein sequence ID" value="CUP26487"/>
        <property type="gene ID" value="ERS852523_01074"/>
    </dbReference>
    <dbReference type="GeneID" id="66494233"/>
    <dbReference type="eggNOG" id="COG1561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005229">
        <property type="entry name" value="CHP00255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013551">
        <property type="entry name" value="DUF1732"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013527">
        <property type="entry name" value="YicC-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30636">
        <property type="entry name" value="PTHR30636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08340">
        <property type="entry name" value="DUF1732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03755">
        <property type="entry name" value="YicC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00255">
        <property type="entry name" value="TIGR00255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YicC_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1732" evidence="2">
        <location>
            <begin position="209"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO28220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP26487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL33117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS90121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="293" mass="34108" checksum="7C74C6FDEFCD62C7" modified="2016-09-07" version="1">MIKSMTGFGRAEVVTKERKITIELKSVNHRYLDLSIKMPRKLNFLEGAVRNLMKTYIQRGKVDVYITYEDYTLDNGALKYNRELASEYITCLKQMQQDFDLDYDIKVSTLSRYPEVLVMEEQSVDEEALWESLEPPLREACEKFVQTRILEGRNLEKDLIGKLDSLEEKVLRVEARSPEVVNAYRTKLEAKVSELLEDTQIDDNRIAAEVILFSDKICNDEETVRLHSHIRNMKKMLTTEKEGIGRKLDFMAQEMNREANTILSKSSDLEISNIAIDLKTEIEKVREQIQNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NCN1</accession>
    <name>A0A174NCN1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HTH-type transcriptional repressor glcR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glcR_2</name>
        <name evidence="5" type="ORF">ERS852478_02310</name>
        <name evidence="6" type="ORF">ERS852523_01631</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
            <strain evidence="6 8">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP44200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705569.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000086_gene4013"/>
    <dbReference type="EnsemblBacteria" id="CUO26560">
        <property type="protein sequence ID" value="CUO26560"/>
        <property type="gene ID" value="ERS852478_02310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP44200">
        <property type="protein sequence ID" value="CUP44200"/>
        <property type="gene ID" value="ERS852523_01631"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO26560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP44200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="254" mass="28499" checksum="C22C4EA68111A643" modified="2016-09-07" version="1">MLALERRNLILEKLQAEKRVVVSELSQLYDVSEETIRRDLDKLEKEGLAIKSYGGAVINEDVSIDLPFNVRKNQNVTGKQKMAELAASLVKDGDHIFLDASTTAVFVAKALKEKERLTVITNSMEILLELADVSGWNIISTGGVMKEGYLAFLGSKTDESIRSYYVDKVIFSCKALDLEWGIMESQEAFGSTKRAMIGSGRKRILVVDSSKFDQTAFSVAGSMKEVDIIVTDKEPTERWKKHFEKFNVKCLYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174P684</accession>
    <name>A0A174P684_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02211</name>
        <name evidence="2" type="ORF">ERS852478_01919</name>
        <name evidence="3" type="ORF">ERS852523_01973</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000018">
        <property type="protein sequence ID" value="CUP54607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000004_gene1959"/>
    <dbReference type="EnsemblBacteria" id="CUO12516">
        <property type="protein sequence ID" value="CUO12516"/>
        <property type="gene ID" value="ERS852478_01919"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP54607">
        <property type="protein sequence ID" value="CUP54607"/>
        <property type="gene ID" value="ERS852523_01973"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1996">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO12516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP54607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="364" mass="41060" checksum="C24162770D4F8438" modified="2016-09-07" version="1">MSMSDLREYKCPACGGAIEFDSKSQKMKCPYCDTEFELETLKELDAQMEREAGQQDDLSGWQTDAGGEWQEGETDGMNVYTCQSCGGEIIADENTGASNCPYCGNPVIMTEKFKGALRPDLVIPFKLDKKAAKEAYYRHIKGRTFLPKAFRRENHIDEIKGLYVPFWLFDGDVDADVRYKATKVRMWSDHDYDYTETSYYSVERSGEMTFVSVPVDGSEKMADDLMESIEPFKISESVDFQTAYLSGYLADKYDVSEKESINRAHDRMKKSAEEVLADTVKGYASVVPENTNVNISGGKAQYALYPVWILNTTWKDKKYIFAMNGQTGKMTGDLPIDRGIYLKWLAGLTAVFTVVLCLAGLLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174PY27</accession>
    <name>A0A174PY27_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_00932</name>
        <name evidence="2" type="ORF">ERS852478_02673</name>
        <name evidence="3" type="ORF">ERS852523_02276</name>
        <name evidence="5" type="ORF">GT712_04790</name>
        <name evidence="4" type="ORF">GT728_17875</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO39180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000023">
        <property type="protein sequence ID" value="CUP63670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000063">
        <property type="protein sequence ID" value="MZL34991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000007">
        <property type="protein sequence ID" value="MZS88421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707826.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000063.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000031_gene322"/>
    <dbReference type="EnsemblBacteria" id="CUO39180">
        <property type="protein sequence ID" value="CUO39180"/>
        <property type="gene ID" value="ERS852478_02673"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP63670">
        <property type="protein sequence ID" value="CUP63670"/>
        <property type="gene ID" value="ERS852523_02276"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50349NE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO39180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP63670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX63453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="61" mass="6593" checksum="BF872D503551116D" modified="2016-09-07" version="1">MSVGRESIRRAANAGAGKTVKKPVVSTKEAEKPETISVTEEKKKTAKGSVHINEELPVYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QQ17</accession>
    <name>A0A174QQ17_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">rnjA</name>
        <name evidence="9" type="synonym">rnj</name>
        <name evidence="15" type="ORF">BWLFYP14_00355</name>
        <name evidence="13" type="ORF">ERS852478_01075</name>
        <name evidence="14" type="ORF">ERS852523_02690</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">2789STDY5834863</strain>
            <strain evidence="14 17">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="15 18" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000030">
        <property type="protein sequence ID" value="CUP75334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000035_gene3833"/>
    <dbReference type="EnsemblBacteria" id="CUN79238">
        <property type="protein sequence ID" value="CUN79238"/>
        <property type="gene ID" value="ERS852478_01075"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP75334">
        <property type="protein sequence ID" value="CUP75334"/>
        <property type="gene ID" value="ERS852523_02690"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="12">
        <location>
            <begin position="98"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="440"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN79238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUP75334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VUX67510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="631" mass="70159" checksum="4F5E30F486FA5812" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174RR08</accession>
    <name>A0A174RR08_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol dehydrogenase catalytic domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Sorbitol dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gutB_3</name>
        <name evidence="5" type="synonym">gutB_1</name>
        <name evidence="5" type="ORF">ERS852478_00821</name>
        <name evidence="6" type="ORF">ERS852523_03020</name>
        <name evidence="8" type="ORF">GT712_14330</name>
        <name evidence="7" type="ORF">GT728_12400</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
            <strain evidence="6 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">BIOML-A1</strain>
            <strain evidence="8 11">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.14" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000037">
        <property type="protein sequence ID" value="CUP84779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000030">
        <property type="protein sequence ID" value="MZL33980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000031">
        <property type="protein sequence ID" value="MZS90214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706353.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000038_gene3323"/>
    <dbReference type="EnsemblBacteria" id="CUN69316">
        <property type="protein sequence ID" value="CUN69316"/>
        <property type="gene ID" value="ERS852478_00821"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP84779">
        <property type="protein sequence ID" value="CUP84779"/>
        <property type="gene ID" value="ERS852523_03020"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="4">
        <location>
            <begin position="7"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN69316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP84779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS90214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="342" mass="37570" checksum="CFC3FAE38676DD87" modified="2016-09-07" version="1">MLQQVMTNPGEIIFREVPVPEIKDNQVLVKIMNIGICGSDIHVYHGKHPFTKYPVTQGHEVSGEVVKTGDAVTEFHVGQKVTIEPQVYCGHCYPCRHGKYNLCEELKVMGFQTTGTASEYFAVDASKVTPIPEDMSYEEGAMIEPLAVAVHGVKQMGDVTGMNIVVIGAGPIGNLVAQSAKGMGAAKVMITDVSDLRLEKAKECGIDVCVNTRNKNFGEAMVEAFGPDKADVIYDCAGNNITMGQAIKYARKGSVIVLVAVFAGMAEIDLAVANDHELDIKSTMMYRHDDYVDGIRLVNEGKVHLRPLISKTFAFKDYLKAYQYIDDNRETTMKVIINVQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WQ18</accession>
    <name>A0A173WQ18_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199476.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41659">
        <property type="protein sequence ID" value="CUN41659"/>
        <property type="gene ID" value="ERS852478_00033"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9PI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032357">
        <property type="entry name" value="DUF4866"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16160">
        <property type="entry name" value="DUF4866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN41659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="266" mass="30111" checksum="06CE020CF7FDAB97" modified="2016-09-07" version="1">MSTVLPREEAVETIFSKILASPEASGRLSGVFYDHIDDDHRLTDNDRDHFLQVLFHAYQNGDISALLLELCGRSMFDLLREAYLIPKKFHGKAGENPVLLTDAAGGLLPGEKVSAREYAKFKETYEHHECAPRSALYLADGYDLVRTYTEGLNITEEKDNRKRGVLALYALPDTCKLGLTEAQAYAVVWDAFQKIQEEAPRAMVYYGQETGLKKENPDKPYDEIGILLPIHEFEKKMLQHLDEIDGIVLVCREKMMEKAGNDSLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WYQ4</accession>
    <name>A0A173WYQ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059504.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44739">
        <property type="protein sequence ID" value="CUN44739"/>
        <property type="gene ID" value="ERS852478_00138"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028348">
        <property type="entry name" value="FAD-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42842">
        <property type="entry name" value="PTHR42842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038984">
        <property type="entry name" value="FAD_binding_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN44739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="531" mass="58593" checksum="AE9DC158788737F3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WZV4</accession>
    <name>A0A173WZV4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine protease inhibitor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Serpin (Serine protease inhibitor)</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Serpin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_02643</name>
        <name evidence="4" type="ORF">ERS852478_00145</name>
        <name evidence="5" type="ORF">GT712_00730</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993915.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44894">
        <property type="protein sequence ID" value="CUN44894"/>
        <property type="gene ID" value="ERS852478_00145"/>
    </dbReference>
    <dbReference type="GeneID" id="66495878"/>
    <dbReference type="eggNOG" id="COG4826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="PTHR11461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="SSF56574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033731910" evidence="2">
        <location>
            <begin position="31"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="SERPIN" evidence="3">
        <location>
            <begin position="59"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN44894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS87651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="414" mass="45327" checksum="6A9B0EC0974EFE84" modified="2016-09-07" version="1">MIRKQLLIGILAAMTVALPAVGIYAGSAEASEIQSSNEDTVSGNKGASIDKAVTLQNSVKMTDQISAAVNGENIMFSPTSLNFALGMIAEGAEGETKEVLCNYLGTDDFASYAKEYLNKIKEYNTEDESYGYKSKLKIADAVWVDNNLTLQEEFKNSVTNGFGAEVENVDFSAAEKTCGIINSWCDKNTEGLIPKIITPDLINDTTGLCLTNSLYFESGWSGEPWNVSDTEEKFGNNEKTKYMTCAGDRYYENDKATAFDREYANGLSFVGILPVDEGDFTLEDLDIGGLLKSQPEYDEVQCKMPKLDFETTAILNDILSSLGLDNIFSSNADFSGIADKNVNVDTILQKTKLELDENGTKAAAVTAVIMECMSAVEEKEPVIKNVELTRPFAFLIYDRSNNEILFMGKVMTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X1F7</accession>
    <name>A0A173X1F7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">uppP_1</name>
        <name evidence="14" type="synonym">uppP</name>
        <name evidence="15" type="ORF">ERS852478_00173</name>
        <name evidence="17" type="ORF">GT712_00590</name>
        <name evidence="16" type="ORF">GT728_06125</name>
    </gene>
    <organism evidence="15 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="16 19 20" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 20">BIOML-A1</strain>
            <strain evidence="17 19">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUN45602"/>
        <property type="gene ID" value="ERS852478_00173"/>
    </dbReference>
    <dbReference type="GeneID" id="66495850"/>
    <dbReference type="eggNOG" id="COG1968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:dephosphorylation"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:peptidoglycan biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UppP"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
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    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
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            <end position="124"/>
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            <end position="153"/>
        </location>
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            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
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            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZL32793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MZS87623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="292" mass="31495" checksum="8646B4F6CCD7C055" modified="2016-09-07" version="1">MIVVYLIFLAVIQAVTEFLPVSSLGHLCILEQYMGIGHETGLLSETMLHLGSAAAIIFLFRKDLKKIGLGLLGMFMDMIGNLNLYIHNKKTGESLGYARIVTGTYRKTGALLVISMIPTALLGLTGKRLALLAADSQIVPGIGFLLTGVFLLVTDLNKSGGKKGPREASYDSAMWIGICQGIAVFPGISRMGFTLCAALLCGYNRKFAVRFSVFMSLPAIIGAFFTEIGNFGASEMTAGLGFTYVFAMIIAGFAGCLVIRNTIAMTQNIKLRYFAYYSFIVGIITLALNFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X1J4</accession>
    <name>A0A173X1J4_9FIRM</name>
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        <submittedName>
            <fullName evidence="1">Sporulation protein YqfC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">YabP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02666</name>
        <name evidence="1" type="ORF">ERS852478_00168</name>
        <name evidence="2" type="ORF">GT728_06150</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YabP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CUN45484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL32798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="94" mass="10513" checksum="27CD1840CF8405AB" modified="2016-09-07" version="1">MKKAGQWKNRMVLALELPPDLAYNETIVTLTGQTEAVIENYKSVFKYTPSEIVIQSFCGKVTISGKNLEIRWYNSSAMKVTGSIYDIKAGDSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X590</accession>
    <name>A0A173X590_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Ferredoxin II</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Ferredoxin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BWLFYP14_02693</name>
        <name evidence="6" type="ORF">ERS852478_00197</name>
        <name evidence="8" type="ORF">GT712_00475</name>
        <name evidence="7" type="ORF">GT728_06010</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">BIOML-A1</strain>
            <strain evidence="8 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380733.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46266">
        <property type="protein sequence ID" value="CUN46266"/>
        <property type="gene ID" value="ERS852478_00197"/>
    </dbReference>
    <dbReference type="GeneID" id="66495827"/>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN46266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL32772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS87602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="163" mass="17152" checksum="CD493DA8C9065DAB" modified="2016-09-07" version="1">MAVKKKFPYRAAVVACNGGCRSAEGEAGCADGCIGCKACIDKCKFGAISINEYGVAEVDEEKCIGCGACAKVCPQKVIHVHECANYIVVKCSNKKKGAEAKKQCNVSCIGCGICEKTCTAGAIKVKDNCAVIEESICLSCGMCAVKCPRHVIHDLHGILTEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XAV1</accession>
    <name>A0A173XAV1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN48783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199523.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN48783">
        <property type="protein sequence ID" value="CUN48783"/>
        <property type="gene ID" value="ERS852478_00248"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN48783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="390" mass="45270" checksum="3C8FF1C1B912E7BF" modified="2016-09-07" version="1">MLNDFTWNMTGYIPKHQVNPHSDSIIPYVAERIFQLEPEPPAVGNLNEYILSALQEKNLIHFSFFLHHYEPQLNKRIKDFLGVDGGDLYDTDRFIDIKLSCREQMLQKLMDYDLTKGAEYATYIYPFIRDAMLRFRMGEEKWSVSSLTNYKMVRSMAWLYHNTKDAVNEFSKKYNCDLALAEDYLKVVRGIRNQQPFYVTDENGEETGEDVALDDSWNYTDILWNGIQAEKVQQAFEKLNYREQTLLEKRLAICMTCGRVSSWKDRPTFEELAVMFEGSTASGAERAYRRAVDKLTELLVAEGALHAVRLKQVSKTKQKKKIAAAIYEYQADCDGDWGEISLDFQNGKVEVMRLADWDTVKSNKFASRAIAYLLNCENEKLPKEIMVAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XDN3</accession>
    <name>A0A173XDN3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49420">
        <property type="protein sequence ID" value="CUN49420"/>
        <property type="gene ID" value="ERS852478_00269"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="44"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN49420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="325" mass="37174" checksum="A6469C3B4742C650" modified="2016-09-07" version="1">MSCYENLVMKTQMNYSRHYSTYASGGTAAVLSKQKPLSYEEQIQEFVRRVQEAECIIVGGASGLSAAGGGDFYYSDTPSFREHFGKFADKYGFKGAFSGMMHRFSTRNEHWGYVATFLNATQNAPIRDPYLDLDRILQGKDFHILTTNQDTQFVKIYPEEKVSEIQGDHRFFQCSQCCQDETWDAVQPVADMIAAMGEGTMVPDELIPRCPHCGAEMFPWVRGYGNFLQGKKYEEEYEKISKYIQKNKDRKILLIELGVGRMTPMFIQEPFWELTNSLKDAYYISVNSEYQFLPEFIEDKGIAILGDIGTVLKDLRKAKEESAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XFL0</accession>
    <name>A0A173XFL0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50454">
        <property type="protein sequence ID" value="CUN50454"/>
        <property type="gene ID" value="ERS852478_00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN50454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="269" mass="31199" checksum="DA212A061046B7BB" modified="2016-09-07" version="1">MNTVIITEKLNTHDHGHMYHQKVGKIGMEIGMEYSYTNTIIRKLFDRNFTYSRKILAMEPREVYAFVINNADLLRHTVREAMATELEQLTLDINQVSKVSFHIPQSCLFTYDGTAKTQLEMKKNVYRGYLSSAEVRSSSERKFEKFCEKCDAVEWVYKNGDKGNEYLSIVYADNSDKQKNFYPDYIISVNGEVWIVETKGGFDRSGNSQDIDIFTPKKFAVLKDYLERYGLKGGIVRYDEKSEELCICMDCYSNDINSDSWVVLSDILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XG05</accession>
    <name>A0A173XG05_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable adenylyltransferase/sulfurtransferase MoeZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">moeZ_1</name>
        <name evidence="2" type="ORF">ERS852478_00287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199549.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49956">
        <property type="protein sequence ID" value="CUN49956"/>
        <property type="gene ID" value="ERS852478_00287"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="11"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN49956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="254" mass="28119" checksum="6BA93481DE02D4D2" modified="2016-09-07" version="1">MLNQFSRTELLLGKEAMNKLKNSRVAVFGIGGVGGYVCEALVRSGVGAFDLIDDDKVCLTNLNRQIIATRKTVGQYKTEVMRDRILDINPKADVRIHNCFYLPENAADFDFSEYDYVVDAVDTVTAKIELIMRAKETGTPVISSMGAGNKLDASAFRVADIYKTKVCPLAKVMRRELKKRGVKKLKVVYSEEQPIRPIEDMAISCRSHCICPPGAAHKCTERRDIPGSVAFVPSVAGLIIAGEVIKDLTAEYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XIZ1</accession>
    <name>A0A173XIZ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione import ATP-binding protein GsiA</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_1</name>
        <name evidence="6" type="ORF">ERS852478_00342</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199578.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51629">
        <property type="protein sequence ID" value="CUN51629"/>
        <property type="gene ID" value="ERS852478_00342"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN51629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="264" mass="29192" checksum="1AC42FA62E37A886" modified="2016-09-07" version="1">MDRKILTYDSVEISFGGKAVVHDVSFSLEHGEILGLVGESGSGKSTLIKAAMGLLGQDGLVTRGDIRYMDQNILDISEKEKRKIRGAGIGMIFQDAGASLCPIRTIGEQIYESMRAHTKITRSEAKSRAMDLFAKLNFKDSQRVWDSYPFELSGGMNQRAGIAIAMLMNPPILFADEPTSALDVSVQRQVVREMLKLRELFGTAIVLVTHDIGVVRAMADTVLVLKNGKTIEYGTADRVLDHPQDPYTRKLLEAVPKLQRKVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XJ53</accession>
    <name>A0A173XJ53_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione import ATP-binding protein GsiA</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gsiA_2</name>
        <name evidence="5" type="ORF">ERS852478_00343</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706762.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51663">
        <property type="protein sequence ID" value="CUN51663"/>
        <property type="gene ID" value="ERS852478_00343"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN51663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="253" mass="28172" checksum="D8C0DDE09D195D50" modified="2016-09-07" version="1">MSILLEAEHLTKTFTQRGKNPLKAVKDVSFTLKKGETLGIVGESGSGKSTIAKLLTRLTDITEGTLKFEGKDITRLKQSQLKEVYGDIQMVFQNPVGSFDPRRTLGDGIGESLRNRGMKKADVEKRVAELLEQCGLEKEYAKRYPHEVSGGQCQRAAIARALAVEPKVLICDEATSALDVTIQKQIMELLEDLKEKKGLSFIFICHNLALVQMFCDRVLVLYEGKVVESGIPDDIINEPKEEYTRRLVDAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XL49</accession>
    <name>A0A173XL49_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative electron transport protein yccM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yccM_2</name>
        <name evidence="7" type="ORF">ERS852478_00364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52369">
        <property type="protein sequence ID" value="CUN52369"/>
        <property type="gene ID" value="ERS852478_00364"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN52369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="206" mass="23848" checksum="EF237460AAC02FFF" modified="2016-09-07" version="1">MLIYLGLICRENMQIEGFWYYLFTGVFEAATIHYAVAKIFGPLLFGRGWCGYACWTAMVLDFLPYKKPQAARKKIGFIRYITFAFSFSFVVLLFLNHVENMEKIMFIAFIVGNILYYIVGIILAFLFKDNRAFCKYICPVTIFLKPMSYFSVVRVKCDKEKCISCGKCKKVCPMNVDITDNSRKRKNGTECILCMECVKTCPRKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XX33</accession>
    <name>A0A173XX33_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L-lactate utilization operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lutR</name>
        <name evidence="5" type="ORF">ERS852478_00462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199645.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56169">
        <property type="protein sequence ID" value="CUN56169"/>
        <property type="gene ID" value="ERS852478_00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN56169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="248" mass="27421" checksum="BEE1A3B15B05534D" modified="2016-09-07" version="1">MFRKIDKTSTFNDVLKQIIEKIQTGELKPGDALPAERILAEEFGISRPALREVLKALSLLGITVSVHGGANYIAADLRNCLTEPLSILFHMYNSKIQDALQLRGALESKAAFLAAQNCTPLDAAELQLIIAKLDSTQDEKVRGDLDRDLHMKIAQISANPLILSVLNASAQLTENMITGIRSYFMKKNNDAPEIDSQHTRLVHAITDKDAPLAEKIMNEHMHTIERLLNEIPFNTLATADKDKSPATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y9A7</accession>
    <name>A0A173Y9A7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">argD_2</name>
        <name evidence="2" type="synonym">argD</name>
        <name evidence="5" type="ORF">BWLFYP14_03308</name>
        <name evidence="4" type="ORF">ERS852478_00561</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX67031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053054.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59308">
        <property type="protein sequence ID" value="CUN59308"/>
        <property type="gene ID" value="ERS852478_00561"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="223"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN59308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX67031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="396" mass="43517" checksum="8F31F8A8288DC982" modified="2016-09-07" version="1">MNMNEQMKESEESILHTYNRFPVVFEKGQGCYLYDSEGKEYLDFAAGIAVNSLGYHYPGYDEALKDQIDKLMHISNLYYNEPIIEAGAKLVKASKMSKAFFTNSGTEAIEGALKAAKKYAYVRDGHADHEIIAMNHSFHGRSIGALSVTGTAHYREPFEPLMGGVKFADFNDLESVKAQITDKTCAIITEVVQGEGGIYPAKKEFLEGLRQICDEKDIMLIFDEIQCGMGRTGHYFAWQAYGVQPDIMTSAKALGCGVPVGAFVLNEKAAKASLEPGDHGTTYGGNPFVCAAVSKVFDIYENDKIIEHVQEMTPYLEQKLDEIVAKHECAATRRGMGFMQGIVIQGRPVGEVVKAALAKGLLVISAGSDVLRIVPPLVITKEHIDKMAAILDECME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YAC6</accession>
    <name>A0A173YAC6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell wall-associated polypeptide CWBP200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">wapA</name>
        <name evidence="1" type="ORF">ERS852478_00588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60197">
        <property type="protein sequence ID" value="CUN60197"/>
        <property type="gene ID" value="ERS852478_00588"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN60197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="405" mass="44695" checksum="2BB59A79923C668A" modified="2016-09-07" version="1">MTETYDSAWKDKLLSWDGTAMTYDAIGNMLTRGGTTYTWTQGRRLSGVENGKSIKYLYDNIGARVKKTVDNTVTEYQWAGDLLLSEKTDGRIIWYCYDSQANLIFVTIRGITYFYVRNVQGDIIALVDADGKVVVKYTSDSWGKVIAVTGELADTVGVQNPFRYKGYYYDNETGMYYLKSRYYDAEIKRFICADGYFSTGVGKHDCNMFLYCNNNPIMNVDVNGYSFISFVKKSISFVKDIVGAVSKGISISGGSAVAIATSDGPSPVMDFVAAGIVLGFSIYEYYKDKIHDNTQTKILSLPRNKKDVVIYRYGGTNPGNLTPSQKDSDTGLSFSTIPPRMGGKAAVTTINTLNKTGIVYAYQDKLTHVSVVPVGVSIQTWINAGSGSIWTQAVKSVVVKWDGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YBT2</accession>
    <name>A0A173YBT2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">carB_1</name>
        <name evidence="5" type="ORF">ERS852478_00619</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993493.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61279">
        <property type="protein sequence ID" value="CUN61279"/>
        <property type="gene ID" value="ERS852478_00619"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="109"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN61279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="432" mass="49978" checksum="02A3AA2EF1FD4094" modified="2016-09-07" version="1">MKHKVLILGTLGEFTELVKKAKEKGYETVVCDGYADGIARTYADKAYTIPVTDVDAIALMCREEGVDGIITSFSDLLLECMVKIADKAGLPCYLKPEQLSWYRDKSACRDVLDKLGLPAPGFRKISVELLKQGSEEEIQQSIANLQYPLISKPLDKYGSRGIFIIHHSDEVRKKALQTAEYTDCQEILVEEYNDGYEFNMMTWVMDGKVNVISIADREKTEMEEGMLPLSTRNVYPSRFLAEVEKSATDILQNYIRYTGQTEGALSMQFFWKPGRGIQVCEIAGRFFGYEHELTDMVYGFQTEELLLDYLYEKDRIKEMFDRHDIYHPVKYGAVLYFQGRQLQIADQTAACELAKEKCVVKPWIFYKEGEHVIEYGPNPYLALYYIETENRRQLEMETEKFFSEMSIRDPEGREVAYRNKIPEYEKEKKTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YEC8</accession>
    <name>A0A173YEC8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN62159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057580.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN62159">
        <property type="protein sequence ID" value="CUN62159"/>
        <property type="gene ID" value="ERS852478_00644"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1910">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12727">
        <property type="entry name" value="PBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="2">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="1">
        <location>
            <begin position="106"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN62159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="312" mass="34810" checksum="F8877A0EDE410781" modified="2016-09-07" version="1">MNKLYTAQEVADRLKIKKTTVYELIKRGELESSKIGKQLRVSEEQLTQYLNRSSSGNSESGQDIPYTSVNFEPESSLLKRDYLLHSSGIILGGQTSAALELLLGKMSAHPDGLPVLQSHMNDYNGLYSLYFEKAHIAATSLDIDDIRHLVPGIPLILLSLYKYSVGFYVPAGNPEKISSVEDLTDPKVVFMNREKGSARRVYLDRLLKEQGISSEKISGYRNEAVSDMSSASAVFEHRANVAFGEEMIARYFPGLDFVPVTDMQMYLAIPAESVRKPGFSALVEIVQSEDFKTEIHHLTGYDTSYTGEMICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YIF2</accession>
    <name>A0A173YIF2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN63724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63724">
        <property type="protein sequence ID" value="CUN63724"/>
        <property type="gene ID" value="ERS852478_00661"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN63724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="650" mass="74817" checksum="B94052506F2B6CCB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZJ87</accession>
    <name>A0A173ZJ87_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable dihydroxyacetone kinase regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76472">
        <property type="protein sequence ID" value="CUN76472"/>
        <property type="gene ID" value="ERS852478_01024"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN76472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="192" mass="22488" checksum="DD3347ED81EE6039" modified="2016-09-07" version="1">MDMINEAGKGEKTKYRLARSMKECMKTMSVDNITVKQITENCGVTRQTFYRNFMDKFDLINWYFDKLLAKSFEHMGMGKTVYDALVKKFTYIQEEHVFFAAAFKYDSQNSLRQHDFELILDFYENLIREKTGRIPDETIHCILEMYCQSSIYMTVKWVLGELECAPEGLAKILVDGMPGKLSELFEKLEILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZS66</accession>
    <name>A0A173ZS66_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF964)</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">YlbF family regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01076</name>
        <name evidence="2" type="ORF">GT712_13565</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000028">
        <property type="protein sequence ID" value="MZS90071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060451.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79282">
        <property type="protein sequence ID" value="CUN79282"/>
        <property type="gene ID" value="ERS852478_01076"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010368">
        <property type="entry name" value="Com_YlbF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023378">
        <property type="entry name" value="YheA/YmcA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06133">
        <property type="entry name" value="Com_YlbF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158622">
        <property type="entry name" value="SSF158622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN79282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS90071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="114" mass="13091" checksum="74408F724649002D" modified="2016-09-07" version="1">MEPNTIEESIKGLLEAIKESPEYLEFQKQSDILKKKPELKARVDTFRADNYKVQNECDSDNLFEVVEQMGKESAELRRHPEVNAYLDAELALCKMMQRICIKLGEGIDIDVPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZWP2</accession>
    <name>A0A173ZWP2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015517515.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79588">
        <property type="protein sequence ID" value="CUN79588"/>
        <property type="gene ID" value="ERS852478_01085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN79588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="150" mass="17218" checksum="DF3D7F46638E5FE4" modified="2016-09-07" version="1">MVGRIYHVGLTVSDLERSIAFYRDVLGLEFQGEIFMEGEETDKMFRRVNCKARVAYLNGSKAVEAPPVELIQFVNNEVKKVPSDLFTTSISEVCFYTDDIDSAYKHLVDNNVECLSEPQYFDFRADGFGESRAFYFRDPDGIILEMMQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A128</accession>
    <name>A0A174A128_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SpoIIIAH-like family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">SpoIIIAH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_03075</name>
        <name evidence="2" type="ORF">ERS852478_01159</name>
        <name evidence="4" type="ORF">GT712_03560</name>
        <name evidence="3" type="ORF">GT728_00395</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994069.1">
        <property type="nucleotide sequence ID" value="NZ_JADPFJ010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82204">
        <property type="protein sequence ID" value="CUN82204"/>
        <property type="gene ID" value="ERS852478_01159"/>
    </dbReference>
    <dbReference type="GeneID" id="66493995"/>
    <dbReference type="eggNOG" id="ENOG5032YS3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024232">
        <property type="entry name" value="SpoIIIAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038503">
        <property type="entry name" value="SpoIIIAH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12685">
        <property type="entry name" value="SpoIIIAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN82204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL31692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="250" mass="27067" checksum="5BFD2ED5CC07F12F" modified="2016-09-07" version="1">MKKVIGKNQVIITSLAILIAVAGYLNFADVDLGFRDKEASTDSSSILEDAGYDLTDETALLDENQADGGLTDNSLTDSQETDTPGEAVFTGSTGFAAQAKISREQVRSQNKADLQDIINNEEIDDEEKQEAIHTMVSMTDLSEKEAAAELLLEAKGFKNVVVNLTGETADVVIPEAELSDAQRAQIEDIVKRKTGIAPENIVITPLKESEDAEDTTQTDETSADTSYEEDSETSAQPYEDTAIDTTDIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A6R5</accession>
    <name>A0A174A6R5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199955.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83579">
        <property type="protein sequence ID" value="CUN83579"/>
        <property type="gene ID" value="ERS852478_01198"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN83579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="446" mass="48330" checksum="A3336E22379DCED6" modified="2016-09-07" version="1">MQTDMTVGKPMKMILDFTIPVFIGNVFQQFYNMADAIIVGKFVGTKGLAAVGSTGTIMFLIIGFLTGLTAGFTVLTSQKFGAGKMDEMRQSVGNAALLSIIISVIMTAVSMVGMHSLLTLMHTPEDIFQDAYTYIMIICGGIFAQVLYNILASILRALGNSKTPLYFLILAALLNIVLDLTFIIVFHMGVAGAAWATITAQGVSGVLCLIYIIKYVPELRLKADDWRFRSEIAKKEILVGIPMGLQYSITAIGTMMVQSALNILGSYAVAAFTAGNKIENIFTQAYVAIGTTMATYNAQNIGARKLDRVRQGFNSAHIIGITYAIVTGVIIFFFGKYLSYLFISDNAAEVIPMVDTYVKCVAVFFIPLHFVNALRNGIQGMGYGLLPMLAGVAELAGRGITAMIAAAHKSYFGACMASPMAWVLAGGLLIIMYFYVMKDMKRRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A9F1</accession>
    <name>A0A174A9F1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN84146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199963.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84146">
        <property type="protein sequence ID" value="CUN84146"/>
        <property type="gene ID" value="ERS852478_01211"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017505" evidence="1">
        <location>
            <begin position="29"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN84146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="453" mass="50667" checksum="033941428FADAE49" modified="2016-09-07" version="1">MKKKALAVLLTASVIAGTMGGTATIVHADEEGKVINIYSWNDEFRQRLEAVYPEVKETSKDGTVTTLNDGTEIHWIINPNQDGVYQQKLDEALMNQADASADDKVDIFLSETDYVYKYTDAAADVAMPLKDLGIDPDKDLADQYDFTKTTASDADGVQRGSTWQCCPGLLVYRRDIAKDVFGTDDPEEVGKKMKDWDTAKATAEELKAKGYYTFASYADTFRLYGNSISQPWVEDGATTVNVDQQVMNWIKDSKEWLDAGYLNKTVKGQWNDDWNKAMGSESKVFAFLFPAWGIDFTLKPNWDGEDGEWAVTNPPQEYNWGGSYIHAATGTDNPEHAKDIILALTGNKDNLLKISKDYSDFTNTKSGMQEVATDDTFASDFLGGQNPFEYFAPVAENIKIAPLSAYDQGCVELIQNAFSDYFQGQVDYDKAKSNFETAIKERYPEIQEVNWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AHQ1</accession>
    <name>A0A174AHQ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_10</name>
        <name evidence="7" type="ORF">ERS852478_01294</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380396.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88152">
        <property type="protein sequence ID" value="CUN88152"/>
        <property type="gene ID" value="ERS852478_01294"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN88152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="282" mass="31587" checksum="170504D15A97DCD5" modified="2016-09-07" version="1">MDSYKKSRRKSIIAWVIAFVLAIGAAIVSFTPFIFMVLNSFKEKFEMLTKGVFQLPDKLNWSNYTEVLTGGFANYFKNSVIVLAISLILLLFISACASYPLARFKFKMAQPIYAIIVACMSIPVHITLIPVFKMSKSTGLYDTIWSLIGPYVAFAVPISVFILTSFMKEIPREIEESAEIDGCGKIQMFFSMILPLSKPGMATLAIYNGVNMWNEFSFVNTLTQSAQNRTLPLAIWEFQGQYSMNTPMIMAVLTLTLLPMVIMFIIFQDKLVKGMTAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AI80</accession>
    <name>A0A174AI80_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trxA_1</name>
        <name evidence="8" type="synonym">trxA</name>
        <name evidence="9" type="synonym">trxA_3</name>
        <name evidence="9" type="ORF">BWLFYP14_01629</name>
        <name evidence="7" type="ORF">ERS852478_01287</name>
        <name evidence="8" type="ORF">GT712_09345</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705666.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87913">
        <property type="protein sequence ID" value="CUN87913"/>
        <property type="gene ID" value="ERS852478_01287"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN87913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS89270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX64774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="100" mass="11078" checksum="77ED680D837CC845" modified="2016-09-07" version="1">MAKEITTANFETEVLKSEKPVLIDFWATWCGPCMRQGPVVEELAEEGYAVGKVDVDQNMALAQQFRVVSIPTLILFKDGAEVKRFVGLTSKEELKSALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AJG3</accession>
    <name>A0A174AJG3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Adenine deaminase</fullName>
            <shortName evidence="5">Adenase</shortName>
            <shortName evidence="5">Adenine aminase</shortName>
            <ecNumber evidence="3 5">3.5.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">adeC</name>
        <name evidence="5" type="synonym">ade</name>
        <name evidence="9" type="ORF">BWLFYP14_01622</name>
        <name evidence="8" type="ORF">ERS852478_01280</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>adenine + H(+) + H2O = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="3 5"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200003.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87675">
        <property type="protein sequence ID" value="CUN87675"/>
        <property type="gene ID" value="ERS852478_01280"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01295">
        <property type="entry name" value="AdeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01518">
        <property type="entry name" value="Adenine_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006679">
        <property type="entry name" value="Adenine_deam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026912">
        <property type="entry name" value="Adenine_deam_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="PTHR11113:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13382">
        <property type="entry name" value="Adenine_deam_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01178">
        <property type="entry name" value="ade"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="66"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Adenine_deam_C" evidence="7">
        <location>
            <begin position="397"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN87675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX64767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="574" mass="62965" checksum="4938DAD4970A6EE4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AT59</accession>
    <name>A0A174AT59_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Inner membrane protein ybaN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybaN</name>
        <name evidence="2" type="ORF">ERS852478_01369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90656">
        <property type="protein sequence ID" value="CUN90656"/>
        <property type="gene ID" value="ERS852478_01369"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007401">
        <property type="entry name" value="DUF454"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35813">
        <property type="entry name" value="PTHR35813"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04304">
        <property type="entry name" value="DUF454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016789">
        <property type="entry name" value="DUF454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN90656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="131" mass="14966" checksum="3E68786E7976F4AA" modified="2016-09-07" version="1">MKHTLKIFWMTLGFLCLGLGTVGIVLPILPTVPFYMATLFFFANSSEKLHSWFLGTNLYRKHLDSFVQKRAMTMGTKLRIMGTVTVIMGIGFLCMKNVPIGRICLIVAWICHVLYFFLRVKTEKEILEGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AZK8</accession>
    <name>A0A174AZK8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200056.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN92825">
        <property type="protein sequence ID" value="CUN92825"/>
        <property type="gene ID" value="ERS852478_01398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN92825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="379" mass="42670" checksum="74C46C204AB7CF66" modified="2016-09-07" version="1">MQEISGSLSEVIRAYSDHNLLVPAATDVQLNPFYKYHVEEVAVDLSENSGDIFKVGSVKTGKTDSKGNDIWQDTYSLSKPLLNKLAMAAGIQFNPHQTYGRRIDNITYRAQAQGAMRKADGTYRSEVDQKEICLEDEEDKYRTEFSDKAVKGITDKKAANAAAEIFKGSWVDTKDKWGKKVKAYVIDEADRERYVERSVKVNMALLKKTWAEKAMTGAKLRVIRALLGTKGSYTKDELKKNFAIPTVIFSPDYSDPQVRQAMLMQGMNSVNNMFGMPQIEVKNVDFATDSNIIDEGDLDNPAFTSELPDEDMGEIQQEAFAQPEQEEPNEPDPQPEEDRTADFQCSRCGTIINEKVYEYSINKFGEPLCIKCQRGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B6V2</accession>
    <name>A0A174B6V2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200120.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95486">
        <property type="protein sequence ID" value="CUN95486"/>
        <property type="gene ID" value="ERS852478_01481"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN95486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="67" mass="7611" checksum="9A770E5E075BB65B" modified="2016-09-07" version="1">MISYTPLWHTLINKGMNKGDLKNMTGLSFGTIASMGKNEPVNLKQIDRICKALHCKIEDVIEYKDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BGF7</accession>
    <name>A0A174BGF7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Primosomal protein DnaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dnaI_2</name>
        <name evidence="3" type="ORF">ERS852478_01586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057304.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00112">
        <property type="protein sequence ID" value="CUO00112"/>
        <property type="gene ID" value="ERS852478_01586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="109"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO00112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="264" mass="30544" checksum="84A2219FCB97B299" modified="2016-09-07" version="1">MENKVTADYLDEEGCLHCGICGKRKQMKVSLMGFEHVVSCLCECEVKARQELDEKMQREEAQRLLYQRKSVGLRERRFWEWKFENDNGSNQKILIVRQYVENWTDMKRKNVGLLLMGPVGTGKSFFAGCIANALLEQGERVMMTNFSRILNEMTSYQADKNQIIQNLVDYPLLIIDDLGIERNSEFALEQVYNVIDSRYCKMLPLIVTTNLGLNEMKSTDLDTAHQRIYSRILEMCVPIYCGGEDKRKEEGTEKLVQVQNLITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BKQ0</accession>
    <name>A0A174BKQ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005344265.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01631">
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        <property type="gene ID" value="ERS852478_01627"/>
    </dbReference>
    <dbReference type="GeneID" id="64113454"/>
    <dbReference type="GeneID" id="67479019"/>
    <dbReference type="Proteomes" id="UP000095431">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO01631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="66" mass="7477" checksum="D696C81517065D23" modified="2016-09-07" version="1">MAINNTLKDIREERNLIQADLAEAIGSCSQTIGRIERGERNPSLEIAIRLAHYLKVPVEDIFQVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BRZ5</accession>
    <name>A0A174BRZ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BWLFYP14_00292</name>
        <name evidence="4" type="ORF">ERS852478_01694</name>
        <name evidence="5" type="ORF">ERS852523_01258</name>
        <name evidence="6" type="ORF">GT728_04880</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">2789STDY5834863</strain>
            <strain evidence="5 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP32526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707307.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000084_gene1836"/>
    <dbReference type="EnsemblBacteria" id="CUO03871">
        <property type="protein sequence ID" value="CUO03871"/>
        <property type="gene ID" value="ERS852478_01694"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP32526">
        <property type="protein sequence ID" value="CUP32526"/>
        <property type="gene ID" value="ERS852523_01258"/>
    </dbReference>
    <dbReference type="GeneID" id="66496158"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO03871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP32526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL32554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX67451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="276" mass="29692" checksum="94D95785F5A4F256" modified="2016-09-07" version="1">MAKECNNTSCDKASCEGCSSSKKQQSFQAEMNAQSNVKHVIGVVSGKGGVGKSFVTGSLANMMAAQGYKVGILDADITGPSIPKMYGLKGAAMANDEGIYPMITKNGIKVMSINLLLPTEDTPVIWRGPVLANMVKQFWTDVIWGDVDYLFVDMPPGTGDVPLTAFQSLPIEGIVIVTSPQDLVKMIVKKAFNMAEMMKIPVLGIVENYSYVKCPDCGKEIKVFGESHIDEIAAELKVPVLGKMPIDMDYATKADGGFFAAIDNQYITDALAVMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C141</accession>
    <name>A0A174C141_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Calcium-transporting ATPase lmo0841</fullName>
            <ecNumber evidence="10">3.6.3.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852478_01724</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.8" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200185.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05600">
        <property type="protein sequence ID" value="CUO05600"/>
        <property type="gene ID" value="ERS852478_01724"/>
    </dbReference>
    <dbReference type="GeneID" id="66492350"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="673"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="742"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="785"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="823"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="854"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="9">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO05600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="878" mass="95235" checksum="5DFD2B5D1003B70B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C4H4</accession>
    <name>A0A174C4H4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function DUF111</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08312">
        <property type="protein sequence ID" value="CUO08312"/>
        <property type="gene ID" value="ERS852478_01810"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002822">
        <property type="entry name" value="Ni_insertion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36566">
        <property type="entry name" value="PTHR36566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01969">
        <property type="entry name" value="DUF111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0533">Nickel</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO08312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="287" mass="31308" checksum="68FAB0D2C12DA800" modified="2016-09-07" version="1">MGKTLYLECYSGISGDMTVGALLDLGADKAVLDRVLQSLPVSGFQIKTGKVVKSGIKACDFDVMLDKDHENHDHDMKYLHGHNENTEGESEIHTHEHVIADHACAHERETAHCHHHHEHRGVKEIAHIIEHSAMTDNAKKIALRIFEILAKAESKAHDVPVEQVHFHEVGAVDSIVDIVSVAVCLDNLDITDVVVPVLYEGCGTVRCQHGILPIPVPAVANVISENHLCIKVTAVEGELVTPTGAAIVAAIRTKDKLPEEFEIKKIGIGAGKRQYECPGILRAMIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CFL9</accession>
    <name>A0A174CFL9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenylyltransferase/cytidyltransferase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Glycerol-3-phosphate cytidylyltransferase</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="primary">tagD_2</name>
        <name evidence="3" type="synonym">tagD_1</name>
        <name evidence="6" type="ORF">BWLFYP14_02219</name>
        <name evidence="2" type="ORF">ERS852478_01911</name>
        <name evidence="3" type="ORF">ERS852523_01965</name>
        <name evidence="5" type="ORF">GT712_17490</name>
        <name evidence="4" type="ORF">GT728_10780</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="protein sequence ID" value="CUP54390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000023">
        <property type="protein sequence ID" value="MZL33670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZS90801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CUO12132">
        <property type="protein sequence ID" value="CUO12132"/>
        <property type="gene ID" value="ERS852478_01911"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP54390">
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        <property type="gene ID" value="ERS852523_01965"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CUO12132.1"/>
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    </evidence>
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            <dbReference type="EMBL" id="CUP54390.1"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="MZL33670.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZS90801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="138" mass="16209" checksum="E9A719FC0C9892B2" modified="2016-09-07" version="1">MEKKIGYTQGTFDMFHIGHLNLIRNAKKHCDYLIVGVNADDLVESYKNKRPIVPLEERAEIVRAIRYVDEVIVTTTLDKKQVWEKVHFNEIYIGDDWKGNARWEKTGKEMEELGAKLVFLPYTKDTSSTMLREKLKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CI55</accession>
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        <submittedName>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
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        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="VUX65831.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13022">
        <property type="protein sequence ID" value="CUO13022"/>
        <property type="gene ID" value="ERS852478_01937"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
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        <property type="entry name" value="Type_1_exporter"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
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        <location>
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        <location>
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        <location>
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            <begin position="380"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO13022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX65831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="604" mass="66244" checksum="CBB96776895FE1DD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CII4</accession>
    <name>A0A174CII4_9FIRM</name>
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            <fullName evidence="2">Helix-turn-helix domain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01893</name>
        <name evidence="4" type="ORF">GT712_19120</name>
        <name evidence="3" type="ORF">GT728_21245</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
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                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
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                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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    <sequence length="223" mass="24113" checksum="F2B0D215B3D89D68" modified="2016-09-07" version="1">MLKDFTIANLLDLNETIAKDLFEGKTYPWEVLPEIGDFILKLGQTLSEEEYDHPSEDVWIAKSAKVAPTACINGPVIIGKEAEVRHCAFIRGKAIIGEGAVVGNSTELKNAVLFNKVQVPHYNYVGDAVLGYKSHMGAGSICSNVKSDKKLVVVKDGDEKIETGLKKFGAMLGDNVEVGCGSVLNPGTVIGRCCNIYPLSSVRGCVPANHIYKSKTEIAEKRS</sequence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4 7 8" key="2">
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                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
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                <person name="Berdy B."/>
                <person name="Zhao S."/>
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            <strain evidence="4 8">BIOML-A1</strain>
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            <end position="329"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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    <sequence length="576" mass="67472" checksum="A14AC4FE019D8724" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
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                <person name="Vlamakis H."/>
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    </reference>
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    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO20057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS89693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="107" mass="12578" checksum="3EF998CC60917EE6" modified="2016-09-07" version="1">MKIEGNQKELDAMVEFHKGNRVEGLRLQEEFAAEFRKEYKDKDHCPCLKACRYHGNCKECVAIHRAHQEHVPNCMRPLINKKLKLMSELTEHTLANEIEAPHEILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7D2</accession>
    <name>A0A174D7D2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200598.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21444">
        <property type="protein sequence ID" value="CUO21444"/>
        <property type="gene ID" value="ERS852478_02161"/>
    </dbReference>
    <dbReference type="GeneID" id="66495325"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO21444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="135" mass="15929" checksum="0043E97F18C88C13" modified="2016-09-07" version="1">MTKEQIIEELKKSAKPYEEYYLDDEILSAMLSYQNPYEFVEPILEIISTNPSVNFGMPGDLVHFVEKFYKKGYEELLINSVRKNPTSHNILMLHRCYNDIKNPNRNEFAKVVKTLKNDKSVSSEIKNIIDEYDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DAU1</accession>
    <name>A0A174DAU1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase III subunit delta'</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dnaX_2</name>
        <name evidence="11" type="synonym">holB</name>
        <name evidence="10" type="ORF">ERS852478_02207</name>
        <name evidence="11" type="ORF">GT728_11130</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000025">
        <property type="protein sequence ID" value="MZL33734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707979.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22852">
        <property type="protein sequence ID" value="CUO22852"/>
        <property type="gene ID" value="ERS852478_02207"/>
    </dbReference>
    <dbReference type="GeneID" id="66493398"/>
    <dbReference type="eggNOG" id="COG2812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004622">
        <property type="entry name" value="DNA_pol_HolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015199">
        <property type="entry name" value="DNA_pol_III_delta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09115">
        <property type="entry name" value="DNApol3-delta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00678">
        <property type="entry name" value="holB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNApol3-delta_C" evidence="9">
        <location>
            <begin position="233"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO22852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL33734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="329" mass="37294" checksum="D55972F3B5E8B183" modified="2016-09-07" version="1">MMGFNNIIGHEEIIGHLKNAIESGKISHSYIFTGEPGSGKKLLAGTFASTLQCEAGGTEPCQKCDSCKKAMGKNHPDIIMVSHEKPGTITIDEIRDQVINDIDIRPYYSPYKIYIIADADLMTPQAQNALLKTIEEPPEYAVILLLTNNIGGLLPTIQSRCVRLDLKVVDDGLVKKYLMEHLHVPDYQAEIDASFAQGSIGRAKEAATSQEFAEMTQNALRILKYANTMEVYELSDAIKSLSEDKQNINDYLDIFQFWFRDVLMFKATQEIDNLVFKQEINFIREQAKQRSYENLENILDSIQKTKVRLKANVNFDLAFELLFLTIREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DF85</accession>
    <name>A0A174DF85_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-dependent Clp protease ATP-binding subunit ClpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">clpC</name>
        <name evidence="9" type="ORF">ERS852478_02221</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO23847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705474.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23847">
        <property type="protein sequence ID" value="CUO23847"/>
        <property type="gene ID" value="ERS852478_02221"/>
    </dbReference>
    <dbReference type="GeneID" id="66495140"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="8">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="423"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO23847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="820" mass="92071" checksum="1AD0E020DE5F2B94" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DJN1</accession>
    <name>A0A174DJN1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01491</name>
        <name evidence="3" type="ORF">ERS852478_02238</name>
        <name evidence="4" type="ORF">GT712_11685</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000022">
        <property type="protein sequence ID" value="MZS89716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993366.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24335">
        <property type="protein sequence ID" value="CUO24335"/>
        <property type="gene ID" value="ERS852478_02238"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033PT0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO24335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="157" mass="16791" checksum="E1EF0E8EAF78505B" modified="2016-09-07" version="1">MSQKKVDAYKARKGLHNKTDRKEKVLFGLEMFAWAFICVVIVAWIGYSAYVKVTGAKENVVQNTVMDTTALDNYISNLSTDASDGTDSTDADTAEEEDTTASTDTDSEDADAADTTADDSETETADKSEEADDTNVADDKAAETADSTTDADSADAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DJZ7</accession>
    <name>A0A174DJZ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antirestriction protein (ArdA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200655.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24659">
        <property type="protein sequence ID" value="CUO24659"/>
        <property type="gene ID" value="ERS852478_02251"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009899">
        <property type="entry name" value="ArdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041893">
        <property type="entry name" value="ArdA_dom3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07275">
        <property type="entry name" value="ArdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO24659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="167" mass="19619" checksum="7F4DC2DC365F0393" modified="2016-09-07" version="1">MQETRVLVETRGTTGEETISYWFDLPIDVAEFEEKLGIGAESGDYRIIEKVLPYADEVHEHTSVYQLNELDFMYRQLSSDMQEEYVSLLTVYENLEALYLCRNVITVYPDCKSMIDVARQKLMNDPTFKHLSEDCQEYYFDFEAYASHLQEHGKFLVTEHGIFELPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DTZ9</accession>
    <name>A0A174DTZ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">khpA</name>
        <name evidence="7" type="ORF">BWLFYP14_02913</name>
        <name evidence="3" type="ORF">ERS852478_02360</name>
        <name evidence="4" type="ORF">ERS852523_00965</name>
        <name evidence="6" type="ORF">GT712_13745</name>
        <name evidence="5" type="ORF">GT728_07915</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP23417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000014">
        <property type="protein sequence ID" value="MZL33132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000029">
        <property type="protein sequence ID" value="MZS90106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000072">
        <property type="protein sequence ID" value="VUX66637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704683.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1079"/>
    <dbReference type="EnsemblBacteria" id="CUO28707">
        <property type="protein sequence ID" value="CUO28707"/>
        <property type="gene ID" value="ERS852478_02360"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23417">
        <property type="protein sequence ID" value="CUP23417"/>
        <property type="gene ID" value="ERS852523_00965"/>
    </dbReference>
    <dbReference type="GeneID" id="66494248"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO28707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP23417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL33132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS90106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="76" mass="8200" checksum="268345E9F0E4B85A" modified="2016-09-07" version="1">MKELVEVIAKSLVENPDEVVVTETEKEDAIIVELKVGPADMGKVIGRQGRIAKAIRTVVKAASSKSSKKVIVDILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DWL6</accession>
    <name>A0A174DWL6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="5">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">queA</name>
        <name evidence="6" type="ORF">ERS852478_02357</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the QueA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200707.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28608">
        <property type="protein sequence ID" value="CUO28608"/>
        <property type="gene ID" value="ERS852478_02357"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO28608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="341" mass="38438" checksum="01D8EADB69A783E4" modified="2016-09-07" version="1">MKTSDFYYDLPQELIAQDPLEDRSSSRLMHLSLKDGSIEHRHFTDVLDYMEEGDCLVINDTKVIPARLYGHKEGTGALIEILLLKRRENDIWECLVKPGKKARPGAKITFGNGILKGEIIDVVDEGNRLIQFHYEGIFEEILDQLGEMPLPPYITHKLKDKNRYQTVYAKNEGSAAAPTAGLHFTKELLEKVKEKGVNIAHVTLHVGLGTFRPVKVDDVESHHMHSEFYIVEEDQAKLINDTKKAGKRVIAVGTTSCRTLESATGEDGILKSGSGWTEIFIYPGYHFKMIDALITNFHLPESTLVMLVSALAGKENIMHAYETAVQEKYRFFSFGDAMIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DWW2</accession>
    <name>A0A174DWW2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium transport protein CorA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">corA</name>
        <name evidence="7" type="ORF">ERS852478_02403</name>
        <name evidence="8" type="ORF">ERS852523_01996</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
            <strain evidence="8 10">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000019">
        <property type="protein sequence ID" value="CUP55368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025576939.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1130"/>
    <dbReference type="EnsemblBacteria" id="CUO30051">
        <property type="protein sequence ID" value="CUO30051"/>
        <property type="gene ID" value="ERS852478_02403"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP55368">
        <property type="protein sequence ID" value="CUP55368"/>
        <property type="gene ID" value="ERS852523_01996"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO30051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP55368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="313" mass="36042" checksum="7B24B64762DE23C8" modified="2016-09-07" version="1">MVRIFKTIDGAIHEIQEPQEGCWIALTNPTATEIFEISEQFGIEVDDLRAPLDEEERSRIEVEDNYTLILADVPAIEERNEKDWYVTIPLGIIVTQKMIFTVCLEDTQVLTRFMEGRVRNFFTYMKTRFILQILYRNASMYLRYLRIIDKKSEQIEEKLHLSTRNQELMELLELEKSLVYFTTSLRSNEMVLEKLLKVESIKKYPEDTELLEDVIIENKQAIEMANIYSGILSSMMGTFASVISNNLNIVMKVLAVITIVMSIPTIVFSAYGMNLSAAGMPFSRTPWGFLIVIILSVVASIIAAIFLSKKKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DYU7</accession>
    <name>A0A174DYU7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kdpE</name>
        <name evidence="14" type="ORF">BWLFYP14_00123</name>
        <name evidence="11" type="ORF">ERS852478_02413</name>
        <name evidence="13" type="ORF">GT712_04390</name>
        <name evidence="12" type="ORF">GT728_01975</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">BIOML-A1</strain>
            <strain evidence="13 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL32002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019161280.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30387">
        <property type="protein sequence ID" value="CUO30387"/>
        <property type="gene ID" value="ERS852478_02413"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="5"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="132"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="132"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO30387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL32002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS88350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX66570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="234" mass="26422" checksum="2D3A04871359CD0D" modified="2016-09-07" version="1">MNKTLILVVEDDRPIRNLIVTTLKTHDYKYLAAENGSSAILEASSHNPDIVLLDLGLPDMEGVEVIKKIRTWSNMPIIVISARSEDTDKIEALDAGADDYITKPFSVEELLARIRVTQRRLAVMQSGEQIESSVFENGGLKIDYTAGCTYLKGEELHLTPIEYKLLCLLSRNVGKVLTHTYITQQIWGRCSDNDVASLRVFMATLRKKLEPEKNGVQYIQTHIGIGYRMLRIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DZZ8</accession>
    <name>A0A174DZZ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">coaBC</name>
        <name evidence="8" type="ORF">BWLFYP14_00100</name>
        <name evidence="7" type="ORF">ERS852478_02436</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO31083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704816.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31083">
        <property type="protein sequence ID" value="CUO31083"/>
        <property type="gene ID" value="ERS852478_02436"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="6"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="186"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="191"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO31083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="402" mass="43821" checksum="CCCBB46572F3E0F8" modified="2016-09-07" version="1">MTLEGKTVLLGVTGSIAAYKIAYLASALKKRHADVHVLMTENATNFINPITFETLTGNKCLVDTFDRNFQFQVEHVSIAKKADVVMIAPASANVIGKLAHGIADDMLTTTIMACKCKKFISPAMNTNMFENPVVQDNLKILEHYGYEVIAPACGYLACGDTGAGKMPEPETLLAYIEREAACEKDLKGKKILVTAGPTQESVDPVRYLTNHSSGKMGYAIAKAAMLRGADVTLVSGRTSIEPPMFVNLIPVVTARDMYEAVTSVSNEQDIIIKAAAVADYRPARISEEKVKKSDGQMSIELERTDDILKFLGEHKQHGQFLCGFSMETQNVIDNSRAKLAKKNLDMVAANNVKVEGAGFQGDTNVLTLITQDEEISLPLMSKEDAAFRILDKILSLMQDSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E5Q1</accession>
    <name>A0A174E5Q1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional repressor yvoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yvoA_2</name>
        <name evidence="2" type="ORF">ERS852478_02499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380894.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33252">
        <property type="protein sequence ID" value="CUO33252"/>
        <property type="gene ID" value="ERS852478_02499"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO33252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="124" mass="14369" checksum="69BE7A3818B31AB3" modified="2016-09-07" version="1">MIVLDYQDRRPIYEQVTDKFQILILNGVLLPGSQMPSVRQLATELSVNPNTIQRAYMELEKLGLIYPVKGRGNFVADSSQVQKINRESYRKEFTALIQKGRNTGFNREELEKMLAEIFEKEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E8K8</accession>
    <name>A0A174E8K8_9FIRM</name>
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        <submittedName>
            <fullName evidence="8">ABC transporter ATP-binding protein YxdL</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Methionine import ATP-binding protein MetN</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">metN_1</name>
        <name evidence="6" type="synonym">metN_3</name>
        <name evidence="8" type="synonym">yxdL_2</name>
        <name evidence="8" type="ORF">BWLFYP14_00527</name>
        <name evidence="5" type="ORF">ERS852478_02532</name>
        <name evidence="6" type="ORF">ERS852523_04287</name>
        <name evidence="7" type="ORF">GT728_13395</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
            <strain evidence="6 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO34114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000098">
        <property type="protein sequence ID" value="CUQ18299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000033">
        <property type="protein sequence ID" value="MZL34171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000004">
        <property type="protein sequence ID" value="VUX62665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703743.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000029_gene653"/>
    <dbReference type="EnsemblBacteria" id="CUO34114">
        <property type="protein sequence ID" value="CUO34114"/>
        <property type="gene ID" value="ERS852478_02532"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ18299">
        <property type="protein sequence ID" value="CUQ18299"/>
        <property type="gene ID" value="ERS852523_04287"/>
    </dbReference>
    <dbReference type="GeneID" id="66495283"/>
    <dbReference type="eggNOG" id="COG1101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO34114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUQ18299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL34171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX62665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="264" mass="29049" checksum="53956206E50EFB66" modified="2016-09-07" version="1">MLELKNIYKTFNPGTINEKRALNGLNLKLNEGDFVTVIGGNGAGKSTMLNAVAGTWPVDEGQILIDNIDVTKLSEHKRATYLGRVFQDPMTGTAATMGIEENLALAKRRGKSRLLRSGITKAEREEYKELLKILGLGLEDRLTSKVGLLSGGQRQALTLLMATLQKPKLLLLDEHTAALDPKTAAKVLEITDMIVNRDHLTTLMITHNMKDAIAHGNRLIMMMEGKIILDIQGEEKKKLTVKNLLDQFEKASGEEFSNDSALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ECR3</accession>
    <name>A0A174ECR3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inner membrane protein YbiR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ybiR</name>
        <name evidence="8" type="ORF">ERS852478_02561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200791.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000079.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35473">
        <property type="protein sequence ID" value="CUO35473"/>
        <property type="gene ID" value="ERS852478_02561"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="7">
        <location>
            <begin position="15"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO35473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="382" mass="42536" checksum="599B9897ADCAC9CA" modified="2016-09-07" version="1">MLQKLYVFFRKETVLSIAVILALLSMFWVRPDKAYFTYIDFRTLGLLFCLMAIVAGLKAVGVFDILAKKLLMGTSGTVGVIRLLVLLCFFLSIVITNDVALITFVPLALIIVHKLPKELGNYWLLKIVAMQTIAANLGSMLTPIGNPQNLYLYARAGMSAAELITLMLPYSATALILLLIWIQVAAAKAPHVCGSEKDKTLLGFSDRKELNMEYLAAYLILFTICLLTVARIIPYQIPLVLVLIYMLLRNRENISRVDYSLLATFIALFIFIGNLGRISQFSSFLERIMAGRETLTAVLASQIMSNVPAALLLSGFTDNYRALIVGTNIGGLGTLIASMASLISFKYIAKENRNLRGKYLGIFTASNIIFMIFMLILYFFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EEE8</accession>
    <name>A0A174EEE8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C/Fe-SP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">acsC</name>
        <name evidence="6" type="ORF">ERS852478_02580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577065.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36091">
        <property type="protein sequence ID" value="CUO36091"/>
        <property type="gene ID" value="ERS852478_02580"/>
    </dbReference>
    <dbReference type="GeneID" id="66494133"/>
    <dbReference type="eggNOG" id="COG1456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016041">
        <property type="entry name" value="Ac-CoA_synth_d_su_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03599">
        <property type="entry name" value="CdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO36091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="452" mass="48556" checksum="134A754DBE63A2EB" modified="2016-09-07" version="1">MALNGIQIFKLTPKKNCKECGCPTCMAFSMKVAQGAMKIEQCPHMSDEALASLSEATAPPMKTIKIGTGAEEHTLGGETVLFRHEKTFVSKPRYAVALCTCMDDAAVEAKLAEIPKVDYDRIGERMYAELVYVNCGEGADAAKYTALVEKAAGLGRTLVLDCKDPEIAKAALAVCKDSKPVLNGADASNYEAMNAVATEAGVVLGVSGKDLNELYDTTAALEKLGNKNLVLDTTGADIKETFANTVQVRRAALKDQDRTFGYPSIVNLVKIAKGDLHLQAALASMFTMKYGSIIVMEQMTYAEALPLYGLRQNVYTDPQKPMKVEPGIYPLNGADENAVVVTTVDFALTYFVVSGELERSGVPLNLVINDAGGLSVLTSWAAGKFSGNSISSYIKENVEPKVKSRKLIIPGKVAVLKGDLEAKLPGWEIIVGPREAVQLVKFLKDLQADGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EHB9</accession>
    <name>A0A174EHB9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S8 family serine peptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Serine protease AprX</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aprX_2</name>
        <name evidence="9" type="synonym">aprX_1</name>
        <name evidence="9" type="ORF">BWLFYP14_01458</name>
        <name evidence="7" type="ORF">ERS852478_02619</name>
        <name evidence="8" type="ORF">GT728_02865</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO37133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000033">
        <property type="protein sequence ID" value="VUX64604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703939.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37133">
        <property type="protein sequence ID" value="CUO37133"/>
        <property type="gene ID" value="ERS852478_02619"/>
    </dbReference>
    <dbReference type="GeneID" id="66494095"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="11"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO37133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL32161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX64604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="281" mass="29981" checksum="D92824C46DDCC180" modified="2016-09-07" version="1">MKNSDDSGYTGKHVGVCVLDTGIFPHIDFTGRILAFQDFIGHRIRPYDDNSHGTHVCGIIGGDGRASEGRIRGIAPGCSLIVLKVLDRTGNGRKEDVLQAFRWILENKRYYGIRVVNISVGTTCRRAEDHRVLIAGVEQLWDAGLVVVAAAGNQGPKAGSVTAPGSSRKIITVGSSDLLTGRTAISGRGPTFECVCKPDLVAPGNHVLACAPGADNGYGVKSGTSMSTPLVAGAAALMLEKNPELTNVQIKMKLKESARDMGLPKNQQGWGELDLERFMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EMI2</accession>
    <name>A0A174EMI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Maltose transport system permease protein malG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">malG_3</name>
        <name evidence="7" type="ORF">ERS852478_02669</name>
        <name evidence="9" type="ORF">GT712_04810</name>
        <name evidence="8" type="ORF">GT728_17895</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">BIOML-A1</strain>
            <strain evidence="9 11">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO39063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000063">
        <property type="protein sequence ID" value="MZL34995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000007">
        <property type="protein sequence ID" value="MZS88425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578978.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39063">
        <property type="protein sequence ID" value="CUO39063"/>
        <property type="gene ID" value="ERS852478_02669"/>
    </dbReference>
    <dbReference type="GeneID" id="66492667"/>
    <dbReference type="eggNOG" id="COG3833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO39063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL34995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS88425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="284" mass="31890" checksum="16FEF8C2818925C8" modified="2016-09-07" version="1">MKKMKDSRTSSIVLHNLLIAVLAFIWLIPIIWLLCTSFSAYSGMNTSTFFPKEWSISNYMKLFHSDSVSQFPQWFLNTFIIACFTCVISTMFVLMVAYATSVMRFKMRKPLMNMAVILNLFPGMLAMIAVYFTLKSFNLTNSYAGLIMVYSASSGLGYLIAKGFFDTVPRALCEAARIDGCSEARIFFQMVLPMSRPIVVYTVISSFLVPWMDFVYAKMILNAGISSKYTVAIGLYKMLDKSLINSYFTQFCAGGVLVSIPISILFMIMQKFYVEGITGGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EQ30</accession>
    <name>A0A174EQ30_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">phoP_2</name>
        <name evidence="12" type="ORF">BWLFYP14_00921</name>
        <name evidence="11" type="ORF">ERS852478_02658</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993326.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38696">
        <property type="protein sequence ID" value="CUO38696"/>
        <property type="gene ID" value="ERS852478_02658"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO38696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX63443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="231" mass="26180" checksum="56CF7D8656E0F670" modified="2016-09-07" version="1">MANILVCDDDKDIVEAIGIYLEQEGYTVIKAYDGVEAINVLRSQPVDLLIIDIMMPKLDGIRTTLKIREENPLPIIILSAKSEDADKILGLNVGADDYVTKPFNPLELVARVKSQLRRYTRLGAAIPVENAHIYETGGLSINDDLKEVRVDGDVVKLTPIEYNILFLLMKNQGRVFSINQIYENIWNEEAVAADNTVAVHIRHIREKIEINPREPRYLKVVWGLGYKIEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EQ72</accession>
    <name>A0A174EQ72_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized vancomycin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_02691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO39974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200840.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39974">
        <property type="protein sequence ID" value="CUO39974"/>
        <property type="gene ID" value="ERS852478_02691"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038054">
        <property type="entry name" value="LD_TPept-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022029">
        <property type="entry name" value="PG-bd_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12229">
        <property type="entry name" value="PG_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143985">
        <property type="entry name" value="SSF143985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_4" evidence="5">
        <location>
            <begin position="235"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="358"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO39974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="480" mass="54152" checksum="A0049ECED4AE8463" modified="2016-09-07" version="1">MDNKEKNRKKKIKVILGICISVFLFLGGGLLAYIHKVDTDTLGRKITIYGLDVSGQNVEKAGQTIRKAFQDKKVVFREDGSQVYQTTVGELGYSLDEGTLQSALTALKQQRDQTRTFLASWKNYEIEYQVNKDEIAEQAALTEDHFGEKERTEAQNAEIRYSKKNKKFVIVKQVAGTQIDEERLRNYVDKTLEAEFQDQLLTGEVKIDLNQQAYKQPSVKASKELKKELKSLNGQLKKYRKATITYTFGNTTETLDSKTVNSWISIQGTKIIIDQEQAGTFISQLANKYNTIYVPRTFHTSMGTDVTVEDNEYGYRIDQSGELSQLLSDLKSGKNVVREPVYSSKGMQRNGTDDLAGSYIEVSLDAQHLWLYKDGGLVTETDIVSGAPTEERHTYTGAWPIAYKASPFTLTSDAYGYDIKVKYWMPFVYGQGLHDAPWQSAFGGNRYKTGNGSHGCINLPEEEAVIIYENIDGGYPIIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EWF3</accession>
    <name>A0A174EWF3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1858 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Hybrid cluster protein-associated redox disulfide domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_00578</name>
        <name evidence="2" type="ORF">ERS852478_02724</name>
        <name evidence="3" type="ORF">ERS852523_02534</name>
        <name evidence="5" type="ORF">GT712_09795</name>
        <name evidence="4" type="ORF">GT728_09530</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000027">
        <property type="protein sequence ID" value="CUP70774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000019">
        <property type="protein sequence ID" value="MZL33432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000017">
        <property type="protein sequence ID" value="MZS89354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707923.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000058_gene2550"/>
    <dbReference type="EnsemblBacteria" id="CUO40876">
        <property type="protein sequence ID" value="CUO40876"/>
        <property type="gene ID" value="ERS852478_02724"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP70774">
        <property type="protein sequence ID" value="CUP70774"/>
        <property type="gene ID" value="ERS852523_02534"/>
    </dbReference>
    <dbReference type="GeneID" id="66493324"/>
    <dbReference type="eggNOG" id="COG2846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023883">
        <property type="entry name" value="CHP03980_redox-disulphide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015077">
        <property type="entry name" value="DUF1858"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038062">
        <property type="entry name" value="ScdA-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39341">
        <property type="entry name" value="PTHR39341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08984">
        <property type="entry name" value="DUF1858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140683">
        <property type="entry name" value="SSF140683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03980">
        <property type="entry name" value="prismane_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1858" evidence="1">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO40876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP70774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX62800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="66" mass="7126" checksum="CA1128C6A52C763B" modified="2016-09-07" version="1">MAKVSKDMLIGQLLQIDANIAPILMRAGMHCLGCPSSQMESLEEAAMVHGLDVDVLVNQINDFLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EWH3</accession>
    <name>A0A174EWH3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type uncharacterized transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_02725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200865.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40896">
        <property type="protein sequence ID" value="CUO40896"/>
        <property type="gene ID" value="ERS852478_02725"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO40896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="326" mass="34787" checksum="30F8E546DE9A3248" modified="2016-09-07" version="1">MSVLIVFIQKAIVQGICILYGALGEIMTEKSGNLNLGIPGIMYMGGISGLMGAFLYEKDNPDPNALVGVLISFLCAFACAAIGGLIYSILTITLRVNQNVTGLALTIFGTGFGNFFGGSISKLAGGVGQISVKVTGSAYTAKIPGLSKIPVIGGILFNYGFLTYLCIIIAVLLSFFLFKTRAGLNLRAIGENPGSADAAGINVIKYKYLSTCIGAGLAGLGGLYFVMEYSGGTWTDNGFGDRGWLAVALVIFALWKPLNAIWGAFLFGALYILYLYIPGLGRSMQEVFKALPYVVTIIVLVFTSFRKKKEHQPPAALGLPYFREER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EY27</accession>
    <name>A0A174EY27_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bifunctional sulfur carrier protein/thiazole synthase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059713.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42694">
        <property type="protein sequence ID" value="CUO42694"/>
        <property type="gene ID" value="ERS852478_02776"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO42694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="68" mass="7578" checksum="F4CAF0B931BF2D76" modified="2016-09-07" version="1">MFITVAGEKKEVKDGLTLPELIAQENVEMPEYVTVSINEEFVVSEDKESTVLKEGDNVEFLYFMGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F427</accession>
    <name>A0A174F427_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacillibactin transport regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">btr_4</name>
        <name evidence="4" type="ORF">ERS852478_02858</name>
        <name evidence="6" type="ORF">GT712_16345</name>
        <name evidence="5" type="ORF">GT728_14410</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">BIOML-A1</strain>
            <strain evidence="6 8">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000038">
        <property type="protein sequence ID" value="MZL34359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000043">
        <property type="protein sequence ID" value="MZS90587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993456.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45112">
        <property type="protein sequence ID" value="CUO45112"/>
        <property type="gene ID" value="ERS852478_02858"/>
    </dbReference>
    <dbReference type="GeneID" id="66494755"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="191"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO45112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL34359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS90587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="299" mass="35384" checksum="62ABC986C62115D1" modified="2016-09-07" version="1">MAFESMYLEEDIHIDRIYTIHYFEYKSDFHFAGERHNFWEFQCVDKGKAEIETDNGIYHLTSGQLIFHRPNEFHNLIAIGNTAPNIVVVSFECDSPCMKFFEKKLLKLSDSERNLMGMLIAEARRCIKTPLDDPYTEKMEKKEDFLFGSQQLIRIYLEQMLIYMIRRNSSPPMTVPVSQFVNLKNNSAVYKRVIAYMEDHIRENITLCDLCHDNMIGRSQLQKIFQEQHQCGAMDFFSRLKIAYARQLIRENQMNFTQISEFLGYSSIHYFSRQFKKISGMTPTEYITSIKALSERERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F8Y9</accession>
    <name>A0A174F8Y9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">HTH-type transcriptional regulator SinR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sinR_1</name>
        <name evidence="3" type="synonym">sinR_2</name>
        <name evidence="3" type="ORF">BWLFYP14_03406</name>
        <name evidence="2" type="ORF">ERS852478_02906</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705155.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46683">
        <property type="protein sequence ID" value="CUO46683"/>
        <property type="gene ID" value="ERS852478_02906"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO46683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX67129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="177" mass="20103" checksum="6834C93416C205DB" modified="2016-09-07" version="1">MVGKKIRAFREFRGYSQIQLAELSGINVGTIRKYELGIRNPKPDQLEKIATALGLNVSVFLDFNIETVGDVLSLLFSIDDSVNLSLAETSDQKISLTFDNPTMQDFFRKWCQFKNVYEKEKAEILAIEDADKRQEELDKLNATQEEWKLRAMGTTIGCHTIVKKGTEGNSIKTYDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FAC4</accession>
    <name>A0A174FAC4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200978.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45619">
        <property type="protein sequence ID" value="CUO45619"/>
        <property type="gene ID" value="ERS852478_02876"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9US">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO45619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="957" mass="110059" checksum="D53103E6438E206F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FLS9</accession>
    <name>A0A174FLS9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">ddl</name>
        <name evidence="13" type="ORF">BWLFYP14_03538</name>
        <name evidence="11" type="ORF">ERS852478_03023</name>
        <name evidence="12" type="ORF">GT712_01495</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053790.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50467">
        <property type="protein sequence ID" value="CUO50467"/>
        <property type="gene ID" value="ERS852478_03023"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="141"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO50467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS87798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX67263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="350" mass="38638" checksum="42E2B9252BD2A99A" modified="2016-09-07" version="1">MKIVVLAGGTSTERTVSITSGTGICKALRQKGHQAILVDIFCGIENVDRENPFPSEYDVDAASEYMSAFNDRIEQMKKERRSFFGPNVLKLCEAADIVFLGLHGANGEDGKVQATFDLMGIKYTGTGYLSSALAMDKGITKQMFLMNNVPTPRGVSMVKEEMTTDLKALGMEFPVVVKTCCGGSSVGVYIVNDQAEYEQALKDAYSYENEVVVEEYIKGREFSVAVVDGKAYPIIEIAPLQGFYDYKNKYQAGSTIETCPAEISPELTEKMQHYAEAGAKALFMEGYCRLDFMMKENGDMYCLEANTLPGMTPTSLIPQEAKVLGIDYPTLCEKLIEVSMKKYPAQDFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FMP6</accession>
    <name>A0A174FMP6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphate ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Phosphate import ATP-binding protein PstB 3</fullName>
            <ecNumber evidence="6">3.6.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pstB3</name>
        <name evidence="7" type="synonym">pstB</name>
        <name evidence="6" type="ORF">ERS852478_02997</name>
        <name evidence="7" type="ORF">GT712_01365</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.27" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO49770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381180.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49770">
        <property type="protein sequence ID" value="CUO49770"/>
        <property type="gene ID" value="ERS852478_02997"/>
    </dbReference>
    <dbReference type="GeneID" id="66495435"/>
    <dbReference type="eggNOG" id="COG1117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015850">
        <property type="entry name" value="ABC_transpr_PstB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423:SF3">
        <property type="entry name" value="PTHR43423:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO49770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS87772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="252" mass="28214" checksum="E8AC90179A7AA3D4" modified="2016-09-07" version="1">MSGNEKITVENMNLHYGKFHALKNINMAIPEKEITAFIGPSGCGKSTLLKSLNRMNDLVEGCVITGKVQLDGEDIYGDMDVNLLRKRVGMVFQKPNPFPMSIYDNIAYGPRTHGIRSKSKLDDIVEKSLRDAAIWDEVKDRLKKSALGMSGGQQQRLCIARALAVQPEVLLMDEPTSALDPISTSKIEELAMELKKDYTIVMVTHNMQQATRISDKTAFFLLGEVVEFDDTDKLFSMPSDKRTEDYITGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FN40</accession>
    <name>A0A174FN40_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">pth</name>
        <name evidence="4" type="ORF">ERS852478_03049</name>
        <name evidence="5" type="ORF">ERS852523_03141</name>
        <name evidence="6" type="ORF">GT712_15055</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
            <strain evidence="5 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000040">
        <property type="protein sequence ID" value="CUP88457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000035">
        <property type="protein sequence ID" value="MZS90350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707705.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000076_gene2623"/>
    <dbReference type="EnsemblBacteria" id="CUO51603">
        <property type="protein sequence ID" value="CUO51603"/>
        <property type="gene ID" value="ERS852478_03049"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP88457">
        <property type="protein sequence ID" value="CUP88457"/>
        <property type="gene ID" value="ERS852523_03141"/>
    </dbReference>
    <dbReference type="GeneID" id="66494658"/>
    <dbReference type="eggNOG" id="COG0193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO51603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP88457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS90350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="193" mass="21340" checksum="F26BC43A4CB16FBE" modified="2016-09-07" version="1">MYLVVGLGNPGKQYEATRHNMGFDTVDRLVEDYNVPQGGVKFNAMYGKTMIGGEKVILMKPLSFMNLSGGPVREMANYFKIDPESELIVIYDDIDLEPGQLRIRKQGSAGGHNGIKDIIRQLGTEKFLRIKVGVGAKPKGWDLADHVLGRFSTEDRKLVDEAIAKAAKAVDIIISQGTDAAMNEYNRKVPVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FPQ6</accession>
    <name>A0A174FPQ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">atpA_3</name>
        <name evidence="10" type="synonym">atpA</name>
        <name evidence="14" type="ORF">ERS852478_03036</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201088.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50836">
        <property type="protein sequence ID" value="CUO50836"/>
        <property type="gene ID" value="ERS852478_03036"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="13">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="11">
        <location>
            <begin position="149"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="12">
        <location>
            <begin position="371"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="169"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="10">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO50836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="509" mass="55432" checksum="4B5622EDA8BB9D05" modified="2016-09-07" version="1">MQLKPEEISKVIRSQIKYYENVIQQNETGTILMVGDGIARASGLVNCMSGELLEFEDGSFGMAQNLEENSVSIVIFGSDENIGEGQTVKRTGKVVSVPVGDAMVGRVVNALGQPIDGAGPIDTKEFRPIESKAPGICERRSVYQPLQTGIKAIDSMIPIGRGQRELIIGDRQTGKTTIATDTIINQKGKDVICIYVAIGQKRSTVATLVENLTRNGAMDYTIVVAATASESSPLQYIAPYSGCAMGEYFMNKGKDVLIIYDDLSKHAVAYRALSLLIRRPPGREAYPGDVFYLHSRLLERAAKLDDEHGGGSMTALPIIETQAGDVSAYIPTNVISITDGQIFLETELFHSGIMPAVNPGISVSRVGGDAQIKAMKKVAGTLKLIYSQYRELQSFAQFGSDLDADTKARLEQGARIVEVLKQNQNAPVPVEKQVAILYAVTKGVLESVKVEDVNVYESGLYTYLDTDAAGVEVMQEIRSTGKLEQETEQKLRSVLDAYTENFLNTRPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FUT2</accession>
    <name>A0A174FUT2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA primase</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaG_5</name>
        <name evidence="6" type="ORF">ERS852478_03128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO54024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201180.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000055.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54024">
        <property type="protein sequence ID" value="CUO54024"/>
        <property type="gene ID" value="ERS852478_03128"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZnF_CHCC" evidence="5">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO54024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="214" mass="24441" checksum="ADDC4DE9831A5BF9" modified="2016-09-07" version="1">MNVFEAVKQSVTTRQAAEHYGIHVGRNGMACCPFHHDKTPSMKLDRRYHCFGCGADGDVIDFTAALYGLGKKEAAVQLAQDFGFSYEDWKPPGKAKKPKPRQKSPEEQFQEAKSRCFRILADYLHLLRAWRKEYAPHSPEESFHPRFVEALQKQDQVEYLLDVLLFGETEEKAALITDYGKDVIQLEQRMAELAAADAARTKKHHERHAATPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G2V4</accession>
    <name>A0A174G2V4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="9">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">ImGP synthase subunit HisF</fullName>
            <shortName evidence="9">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">hisF</name>
        <name evidence="15" type="ORF">BWLFYP14_02236</name>
        <name evidence="11" type="ORF">ERS852478_03208</name>
        <name evidence="12" type="ORF">ERS852523_01947</name>
        <name evidence="14" type="ORF">GT712_14610</name>
        <name evidence="13" type="ORF">GT728_20395</name>
    </gene>
    <organism evidence="11 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 16">2789STDY5834863</strain>
            <strain evidence="12 17">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="13 19 20" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 20">BIOML-A1</strain>
            <strain evidence="14 19">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="15 18" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000018">
        <property type="protein sequence ID" value="CUP53906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000101">
        <property type="protein sequence ID" value="MZL35462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000032">
        <property type="protein sequence ID" value="MZS90268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703500.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000101.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000004_gene1936"/>
    <dbReference type="EnsemblBacteria" id="CUO56814">
        <property type="protein sequence ID" value="CUO56814"/>
        <property type="gene ID" value="ERS852478_03208"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP53906">
        <property type="protein sequence ID" value="CUP53906"/>
        <property type="gene ID" value="ERS852523_01947"/>
    </dbReference>
    <dbReference type="GeneID" id="66493899"/>
    <dbReference type="eggNOG" id="COG0107">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="9">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO56814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP53906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL35462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS90268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VUX65870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="252" mass="27025" checksum="2E48A297E7307597" modified="2016-09-07" version="1">MFTKRIIPCLDVNNGRVVKGVNFVQLRDAGDPVEIAKAYDAAGADELVFLDITASCEQRDTVVDMVRRVAANVFIPFTVGGGIRTVDDFKKLLREGADKISVNSAAIDRPELISEAADKFGSQCVVVAIDAKRREDGGWNIYKHGGRLDTGIDAIEWAKKVEALGAGEILLTSMDCDGTKAGYDLALTRAIADAVSIPVIASGGAGTLEHFYDALTEGGADAALAASLFHYKELEISQVKDYLSDRGISVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G608</accession>
    <name>A0A174G608_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine aminotransferase</fullName>
            <ecNumber evidence="6">2.6.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphohydroxythreonine aminotransferase</fullName>
            <shortName evidence="6">PSAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">serC</name>
        <name evidence="8" type="ORF">ERS852478_03199</name>
        <name evidence="9" type="ORF">GT712_14565</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 6">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="6">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000032">
        <property type="protein sequence ID" value="MZS90259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577082.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56556">
        <property type="protein sequence ID" value="CUO56556"/>
        <property type="gene ID" value="ERS852478_03199"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00611">
        <property type="entry name" value="PSAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PTHR43247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01364">
        <property type="entry name" value="serC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="4"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO56556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS90259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="360" mass="40213" checksum="9074C25AD93F45F5" modified="2016-09-07" version="1">MSRVYNFSAGPAVLPEEVLKEVAEEMMDYQGTGMSVMEMSHRSADFQKIIDEAEQDLRDLMKIPDNYKVLFLQGGASQQFAAIPMNLMKNKVADYIVTGQWAKKAYQEAQKYGKANKIASSEDKTFSYIPDCSDLPISPDADYVYICENNTIYGTKFKKLPNTKGKTLVADVSSCFLSEPVDVSKYGIIYGGVQKNIGPAGMVISIIREDLITDDVLEGTPTMLKFKTQADAGSLYNTPNCYCIYVCGKVFKWLKKMGGLEEMQRRNIEKAKILYDFLDQSKLFKGTVVPEDRSLMNVPFVTGDKDMDAKFVKEAKEAGLVNLKGHRTVGGMRASIYNAMPKEGVEALVAFMKKFEEENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G689</accession>
    <name>A0A174G689_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ydcV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ydcV</name>
        <name evidence="7" type="ORF">ERS852478_03192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201228.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56359">
        <property type="protein sequence ID" value="CUO56359"/>
        <property type="gene ID" value="ERS852478_03192"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="61"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO56359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="257" mass="28367" checksum="026F74A4086725A7" modified="2016-09-07" version="1">MKKNSRFAGFYMGLIFFLMYLPIAVVIVFSFNESKLPVKFTGFSLKWYQELFHDRAMLEALVNSLILGVLSCLVSAVIGTLGAVGLSRIHWKSKGALEYISILPLMIPEIILGMVLMAFFYMLNLPFGMLTLLIGHTVFCVPYILMEVKARLAGMDPALEEAARDLGAGPFRAFQDITLPLIMPAVISGSLLAFAMSMDDVVISIFVNGPRLSTLPIKVYTQLKTGVTPEINALCTILLAATLVIFIVYSLITKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GDD4</accession>
    <name>A0A174GDD4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HTH-type transcriptional regulator ZntR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Zn(II)-responsive regulator of zntA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">zntR_2</name>
        <name evidence="4" type="ORF">BWLFYP14_00746</name>
        <name evidence="3" type="ORF">ERS852478_03320</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000019">
        <property type="protein sequence ID" value="VUX62997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704913.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60524">
        <property type="protein sequence ID" value="CUO60524"/>
        <property type="gene ID" value="ERS852478_03320"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012867">
        <property type="entry name" value="DUF1648"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07853">
        <property type="entry name" value="DUF1648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO60524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX62997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="281" mass="32571" checksum="A6CC557FA929D636" modified="2016-09-07" version="1">MKIKNVEERTGLSRSNVRFYEKEKLIEPSRNESNGYRDYSENDVENIKKIAYLRTLGISIEDIRSIISGKVTLQETLERQNEILNSQITDLNKAKRMCEKMLGEESISYEKLQVEQYVTELQDYWKDNQTVFKLDSVSFLYIWGSMLTWITITVLCLIIGTLSYSKLPTEIPVQWSKGVATSLVNKNWIFICPVICVIIRYLLKPFIYAKLQMNNYYGEIITEYLTNYMCFIVLSVEVFSILFTFGVVKSVVVLLFVNTAVFMGLLVVGLTKMDLRGKEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GE47</accession>
    <name>A0A174GE47_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC exporter transmembrane subunit, DevC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_03291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO59408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201265.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59408">
        <property type="protein sequence ID" value="CUO59408"/>
        <property type="gene ID" value="ERS852478_03291"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="748"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="804"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="839"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="306"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="780"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO59408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="881" mass="97660" checksum="94EED1B358D411DC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GG70</accession>
    <name>A0A174GG70_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">LL-diaminopimelate aminotransferase</fullName>
            <shortName evidence="7">DAP-AT</shortName>
            <shortName evidence="7">DAP-aminotransferase</shortName>
            <shortName evidence="7">LL-DAP-aminotransferase</shortName>
            <ecNumber evidence="4 7">2.6.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">dapL</name>
        <name evidence="9" type="ORF">ERS852478_03332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23988"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="EC" id="2.6.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.83" evidence="4 7"/>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381182.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60941">
        <property type="protein sequence ID" value="CUO60941"/>
        <property type="gene ID" value="ERS852478_03332"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010285">
        <property type="term" value="F:L,L-diaminopimelate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033362">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01642">
        <property type="entry name" value="DapL_aminotrans_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019942">
        <property type="entry name" value="DapL/ALD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43144">
        <property type="entry name" value="PTHR43144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03542">
        <property type="entry name" value="DAPAT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="8">
        <location>
            <begin position="35"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="108"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="7">
        <location>
            <begin position="247"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO60941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="404" mass="44388" checksum="048096483AEBAC04" modified="2016-09-07" version="1">MVTVNHNYLKLPGSYLFSTIGKKVKAYKEANPQANVISLGIGDVTQPLAPAIIEALHKSVDEMGDAATFHGYAPDLGYEFLRSAIAKNDYKDRGCDIEADEIFVSDGAKSDSGNIQEIFGLDNKIAVCDPVYPVYVDTNVMAGRTGEYNKERGNFDNVIYMPCTEANGFLPEFPEEVPDLIYLCFPNNPTGGAITKPQLQEWVDYANKNGSVIIYDAAYEAYISEENVPHSIYECEGARTCAIELRSFSKNAGFTGVRLGFTVVPKDLVRDGVDLHSLWARRHGTKFNGAPYIVQRAGEAVYSPEGKAQLKEQVGYYMSNAKAIYEGLASAGYSVSGGVNAPYIWLKTPDKMTSWEFFDYLLEKANIVGTPGSGFGAHGEGFFRLTAFGTHENTLEAIERIKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GH26</accession>
    <name>A0A174GH26_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ammonia transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">amtB</name>
        <name evidence="11" type="ORF">ERS852478_03310</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the P(II) protein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60179">
        <property type="protein sequence ID" value="CUO60179"/>
        <property type="gene ID" value="ERS852478_03310"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="10">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO60179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="454" mass="47806" checksum="6C831277653F8F68" modified="2016-09-07" version="1">MAERTKFLSYCIYSLMISLVVYPVSGHWIWGGGFISQMGFHDFAGSCAVHMVGGVAALIGAIILGPRIGKYTKDGKSKAIPGHNLTVGALGVFILWFCWFGFNGASTVSMEGDAIVSAGKIFVTTNLSAAVATVTVMIITWVRYKKPDVSMSLNGSLAGLVAITAGCDTVSPTSAAIIGIASGFIVVFGIEFIDKVLKIDDPVGAVGVHGLNGAFGTLAVGLFSDGSGTDWKGLLTGGGFHGFGVQFTGMIITIAWVVVTMTIIFQVIKHTIGLRVSAEEEIAGLDSKEHGLASAYDGFAMAGVPTPMGTSIKAPVVTARPSAPAESVPELPKEGVHKLTKVVIITRQNKLDEFMQAMNEIGVTGITITNVLGCGVQKGAPSYYRGVEMEMNLLPKVKIEIVVSLVPVQKVIETAKAVLHTGQIGDGKVFVYDIENVVKIRTGEEGYLALQDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GHH8</accession>
    <name>A0A174GHH8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate synthase [NADPH] small chain</fullName>
            <ecNumber evidence="7">1.4.1.13</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Glutamate synthase small subunit</fullName>
            <ecNumber evidence="8">1.4.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gltD_3</name>
        <name evidence="9" type="synonym">gltB_1</name>
        <name evidence="8" type="synonym">gltD</name>
        <name evidence="9" type="ORF">BWLFYP14_00749</name>
        <name evidence="7" type="ORF">ERS852478_03317</name>
        <name evidence="8" type="ORF">GT728_14630</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="7"/>
    <dbReference type="EC" id="1.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000039">
        <property type="protein sequence ID" value="MZL34399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000019">
        <property type="protein sequence ID" value="VUX63000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704919.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60410">
        <property type="protein sequence ID" value="CUO60410"/>
        <property type="gene ID" value="ERS852478_03317"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="6">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="154"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO60410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL34399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX63000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="494" mass="54319" checksum="A61F7A9127B05B3C" modified="2016-09-07" version="1">MGKPTGFLEYKRETAKVLPPKVRIANFKEFRTPLNKEKQKLQGARCMACGVPFCQSGMMIGGMASGCPLHNLVPETNDLVYTGNWKQAFLRLSKTHSFPEFTSRVCPALCEAACTCNLNGEPVSTKENERAIIETAYENGWVTPQIPEVRTGKSIAVIGSGPSGLAAAQQLNRRGHSVTVFERKDRVGGLLRYGIPNMKLDKAVVDRRIHLMEEEGVKFVTNVNVGKDIKAEELLKQFDRVILACGASNPRDIKVPGRDAKGIYFAVDFLGQVTKALLDSDFAKVPYELAKGKNVLVIGGGDTGNDCVGTSIRLGAKSVIQLEMMPKPPVERTPSNPWPQWPRVLKTDYGQEEAIAVFGHDPRVYQTTVTEFIKDKNGNVCQAKLTKLKSEKDPKTGRMMMVPVEGTEEVIPVDVVLIAAGFLGSEKYVTDAFKVAINGRTNVDTKPDQYQTSVDKVFTAGDMHRGQSLVVWAIREGREAAKAVDESLMGYSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GI82</accession>
    <name>A0A174GI82_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_00756</name>
        <name evidence="1" type="ORF">ERS852478_03309</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000019">
        <property type="protein sequence ID" value="VUX63007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60145">
        <property type="protein sequence ID" value="CUO60145"/>
        <property type="gene ID" value="ERS852478_03309"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50349A5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO60145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX63007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="52" mass="5835" checksum="4494354CDD919495" modified="2016-09-07" version="1">MALAQATKSHEPTYTINDAMDVLLSRLDEAIDDMESDRVQIVEEAWAEIDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GKY9</accession>
    <name>A0A174GKY9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201299.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61559">
        <property type="protein sequence ID" value="CUO61559"/>
        <property type="gene ID" value="ERS852478_03347"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO61559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="285" mass="33162" checksum="0DAB63542B5E478B" modified="2016-09-07" version="1">MIYTKKANFPYPILMNFTDDYTDARFELDVNIRDNSDEYIVDVMWDISSKYITELLRNKKASLYLIIKSKDNQFYELQYSRNPQIIIPKRKLCINTRTVMQLIIQVKEDIDFSNNYDLNTFYENTKSEICIKKGNALGFSNIVVFDGSQNKPLDLFERKVDKDIKSDVEISLGTETILIIYKNEELQFSGIQNSKELNYPYIYMGLQKALMQFIYHNNPISVEEGIQIDEMDPPGSALELKLYSLMQAKNVTELSMDNMDEVIYKISDNLLARYKDAVRGLGNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GM21</accession>
    <name>A0A174GM21_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysialic acid transport ATP-binding protein KpsT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">kpsT</name>
        <name evidence="4" type="ORF">ERS852478_03372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO62218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052433.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000072.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62218">
        <property type="protein sequence ID" value="CUO62218"/>
        <property type="gene ID" value="ERS852478_03372"/>
    </dbReference>
    <dbReference type="GeneID" id="66494073"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="27"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO62218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="134" mass="15141" checksum="DC20B65AE6271A76" modified="2016-09-07" version="1">MDIKVDHVSKAYGEQQILRDLCCVFPEGKTTCIRGRSGCGKTTLIRLLLGLDIPDKGKIEGISDRKISAVFQEDRLCENLSAASNIRLVCTETIDYILKKTEGKTLIFVTHEEQEAVWLKADKTLKFMKDHLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GR14</accession>
    <name>A0A174GR14_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphodiesterase YaeI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201381.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63360">
        <property type="protein sequence ID" value="CUO63360"/>
        <property type="gene ID" value="ERS852478_03405"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="22"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO63360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="269" mass="30633" checksum="1BC514E39C4EA956" modified="2016-09-07" version="1">MKRFKTVHYTIHSNKIKDARGIRFAVLADLHGMEFGPDNRKLLETIHRYRPDGILIAGDMIVRNDSASLKTASSLLRSLAQQYPVYYALGNHEYKLYRTDPQENCMAARYQEYEKELKTAGIHILHNESCSLQVGKTSLTVYGLEVPLIYYKKPFSPQLKREEVRELIGEPSSDSLNILLAHSPKYGDTYFDWGADLILSGHYHGGIVRIGRHNGLLSPQLHPFPKFCCGDFHRKEQHMLVSAGAGEHTIPVRIHNPRELLMVDLKPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GSN2</accession>
    <name>A0A174GSN2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Probable diguanylate cyclase YfiN</fullName>
            <ecNumber evidence="3 6">2.7.7.65</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Putative diguanylate cyclase YfiN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yfiN</name>
        <name evidence="6" type="ORF">BWLFYP14_02352</name>
        <name evidence="3" type="ORF">ERS852478_03482</name>
        <name evidence="5" type="ORF">GT712_16520</name>
        <name evidence="4" type="ORF">GT728_16045</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">BIOML-A1</strain>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.65" evidence="3 6"/>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708185.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65712">
        <property type="protein sequence ID" value="CUO65712"/>
        <property type="gene ID" value="ERS852478_03482"/>
    </dbReference>
    <dbReference type="GeneID" id="66493925"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="222"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO65712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="349" mass="39769" checksum="BD4BEAAFF4FC65E0" modified="2016-09-07" version="1">MKTNKKSKNLIGIIQSFLILILVVLIIFMMIQISRLQGTARVINYAGLVRGATQREIKLEITGNQNDELIKYLDDILLGLRYQDGHYDLVKLNDEEYQEKLQIQSDYWDKLKTEIEAVRNKGYENTDIVNMSEIYFTMADETVSAAESYSEKIAVKIRTIELLSALDMLSLVILVIMQTLKAMQMAMQNRLLEQKAFVDAHTGLPNKNACNELLNKKDIITDSTACIMFDLNNLKTVNDTMGHSAGDQLILNFAKLLCSVIPEKDFVGRYGGDEFIAVIYHTSEAEIKEILKSLSREKERLNSCENQLPIDYACGWALSSDDMACTMQMLLDDADAYMYKNKQLCKKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GU05</accession>
    <name>A0A174GU05_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-ribose-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rbsB_5</name>
        <name evidence="3" type="ORF">ERS852478_03492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060740.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPN010000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66182">
        <property type="protein sequence ID" value="CUO66182"/>
        <property type="gene ID" value="ERS852478_03492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022834" evidence="1">
        <location>
            <begin position="31"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="60"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO66182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="368" mass="39229" checksum="202C5CBAD6F6A524" modified="2016-09-07" version="1">MAKWKQMKMIVGSIMVGALLMPTMSITAWANAETEVTVDNFESEILPNLAIKEDGTPLKVAITVAELDSEYVIAVQKYAQYLLETAGAEVTVSSADGDVENQCNQIYDFIEKGVDVVLIQAADSNAVAPAVKACNEAGVTAIAVGRAINGDCTVDYSALIDDVAMGKLAAEYIADNAGEGATVTTMQGTLGTASADDRTTGFAEGVEEYGLDDIRDNPCDWSSESSMAAMNDILTTNEDIDAVFLHSDCMLAGVISGLTQSEKLKTLDDPEHIMIVSIDGAASAMDYIRQEYVDMTVDNSPLALATIAVKAVLTKTVKGEELGGGVTKVNASVITKDNVDEAEFWGNFDLEDGYWSETANIWNTYAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H403</accession>
    <name>A0A174H403_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67800">
        <property type="protein sequence ID" value="CUO67800"/>
        <property type="gene ID" value="ERS852478_03553"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO67800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="50" mass="5747" checksum="53BCE71EB441C8A1" modified="2016-09-07" version="1">MGNENLIQNTELPNEQLKDETETFNSFINVMVQIVEKYGKTVLQELDFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H4G2</accession>
    <name>A0A174H4G2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201433.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68108">
        <property type="protein sequence ID" value="CUO68108"/>
        <property type="gene ID" value="ERS852478_03559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO68108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="153" mass="18096" checksum="370E201960DAE750" modified="2016-09-07" version="1">MRELRKVFNPVLGMKSEKDIEKGYRKIVSAYEVLHAKSQQMREEAEKTILYERMLDFARTLIFPPKSITAEDLKNEYWKIVQTKCRQELKAIRASITDFDKLLTSLSTKYPDESQLLVELRESVEKEIEQEDMKSRRETKDWSQQQSKLGCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H869</accession>
    <name>A0A174H869_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03601</name>
        <name evidence="3" type="ORF">ERS852523_00222</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000002">
        <property type="protein sequence ID" value="CUP00663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004611627.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69388">
        <property type="protein sequence ID" value="CUO69388"/>
        <property type="gene ID" value="ERS852478_03601"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00663">
        <property type="protein sequence ID" value="CUP00663"/>
        <property type="gene ID" value="ERS852523_00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024760">
        <property type="entry name" value="HTH_dom_conjug_TS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12645">
        <property type="entry name" value="HTH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_16" evidence="1">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP00663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="80" mass="8968" checksum="6E19A01D9651F3F4" modified="2016-09-07" version="1">MKQSSYKGKSPLPDFVIDAACAGNAEAVERVLQHYDGYINKLCTRTLYDGSGQPHICIDEYMKRRLQIKLIHSIVSPIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H8S8</accession>
    <name>A0A174H8S8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201478.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000077.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71313">
        <property type="protein sequence ID" value="CUO71313"/>
        <property type="gene ID" value="ERS852478_03663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="137" mass="15996" checksum="F706A03E744B79C1" modified="2016-09-07" version="1">MKKRWFISLIIGIIMVISGCLGYLQYGRDMDVYGSYAMTADNYHEERLTVVVNKLYVADQKVCAEEIVKRCRENSFKSVRFSYDQSIPNALYVTVYSSKRQAEKGKQMFSFSYLPEDSDETYNIVNDSDKFMLKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HDE4</accession>
    <name>A0A174HDE4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Sporulation initiation inhibitor protein soj</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">soj_7</name>
        <name evidence="2" type="ORF">ERS852478_03721</name>
        <name evidence="4" type="ORF">GT712_18525</name>
        <name evidence="3" type="ORF">GT728_02365</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000045">
        <property type="protein sequence ID" value="CUO72942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000061">
        <property type="protein sequence ID" value="MZS90984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703831.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72942">
        <property type="protein sequence ID" value="CUO72942"/>
        <property type="gene ID" value="ERS852478_03721"/>
    </dbReference>
    <dbReference type="GeneID" id="66495312"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="3"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="261" mass="28707" checksum="C191BD7B6DCD4ACB" modified="2016-09-07" version="1">MARIISIVNQKGGTGKSACTANLAVGLAQKNMKVLIVDADPQSDVSAGFGYRDCDDSNETLTALMDAVMKDEDIPSECFIRHQAEGIDIICSNIGLAGTEVQLVNAMSREYVLKQILYGIKDQYDVVIIDCMPSLGMITINALAASDEVLIPVEASYLPIKGLQQLLKTIGKVRKQINPKLQVGGILFTMVDAHTNDARNNMELLRNVYGSQIHIFDNYIPFSVRMKEAVREGQSIFSYDPKGKATEAYRRVTEEVLKDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HFV2</accession>
    <name>A0A174HFV2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional activator tipA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tipA</name>
        <name evidence="3" type="ORF">ERS852478_03690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO72038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201494.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72038">
        <property type="protein sequence ID" value="CUO72038"/>
        <property type="gene ID" value="ERS852478_03690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO72038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="244" mass="28176" checksum="BC52597423379BE9" modified="2016-09-07" version="1">MLKYTTGEIAKLCGVSVRTVQYYDERGILIPSELSEGGRRLYSEDDYKKLKIICFLRDAGISIKSIGELLSESNPSRVISVLLEKQEQLLQNEVKERQEQLAMLEGIKKALKGIENFSVESIGDIAYAMENKKKMKQLHAVLLITGIPLNIIQWVSIILWITTGIQWLFWGYILVAIPYAIFIIRFLSKRIVYICPQCHEIFKPHLKEFIFSNHSMTLRKLTCTSCGYHGFCVETYREEEKNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HJE7</accession>
    <name>A0A174HJE7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03726</name>
        <name evidence="4" type="ORF">GT712_18505</name>
        <name evidence="3" type="ORF">GT728_02345</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000045">
        <property type="protein sequence ID" value="CUO73045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000061">
        <property type="protein sequence ID" value="MZS90981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703822.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73045">
        <property type="protein sequence ID" value="CUO73045"/>
        <property type="gene ID" value="ERS852478_03726"/>
    </dbReference>
    <dbReference type="GeneID" id="42700404"/>
    <dbReference type="GeneID" id="66495308"/>
    <dbReference type="eggNOG" id="COG3655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO73045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="70" mass="7961" checksum="196474E858E8C251" modified="2016-09-07" version="1">MKVRYNKLWKLLIDKGMKKSQLREAVGASKSTFAKLGKNENVTLPVLLNICEYLECDFGDIMEAVPENEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JDP5</accession>
    <name>A0A174JDP5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">dnaG_1</name>
        <name evidence="12" type="synonym">dnaG</name>
        <name evidence="17" type="synonym">dnaG_3</name>
        <name evidence="20" type="ORF">BWLFYP14_02392</name>
        <name evidence="17" type="ORF">ERS852478_02053</name>
        <name evidence="18" type="ORF">ERS852523_00036</name>
        <name evidence="19" type="ORF">GT712_14060</name>
    </gene>
    <organism evidence="18 22">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 21 22" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 21">2789STDY5834863</strain>
            <strain evidence="18 22">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="19 24" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 24">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="20 23" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO95230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000030">
        <property type="protein sequence ID" value="MZS90165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX66021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053826.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2205"/>
    <dbReference type="EnsemblBacteria" id="CUO17430">
        <property type="protein sequence ID" value="CUO17430"/>
        <property type="gene ID" value="ERS852478_02053"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95230">
        <property type="protein sequence ID" value="CUO95230"/>
        <property type="gene ID" value="ERS852523_00036"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="16">
        <location>
            <begin position="255"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUO17430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CUO95230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MZS90165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VUX66021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="598" mass="68662" checksum="FA011E6D3AE8B99C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KDY0</accession>
    <name>A0A174KDY0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">tpiA</name>
        <name evidence="5" type="ORF">ERS852478_01190</name>
        <name evidence="6" type="ORF">ERS852523_00510</name>
        <name evidence="7" type="ORF">GT728_00245</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">2789STDY5834863</strain>
            <strain evidence="6 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP08636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381027.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2113"/>
    <dbReference type="EnsemblBacteria" id="CUN83283">
        <property type="protein sequence ID" value="CUN83283"/>
        <property type="gene ID" value="ERS852478_01190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08636">
        <property type="protein sequence ID" value="CUP08636"/>
        <property type="gene ID" value="ERS852523_00510"/>
    </dbReference>
    <dbReference type="GeneID" id="66494025"/>
    <dbReference type="eggNOG" id="COG0149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN83283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP08636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL31662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="249" mass="26899" checksum="6D64BE0DFDF85E69" modified="2016-09-07" version="1">MARKKIIAGNWKMNMTPSEAVKLVETLKPLVVNDEVDVVFCVPAIDIIPVVEAAKGTNIQVGAENMYFEEKGAYTGEISPAMLVDAGVKYVVLGHSERREYFGETNEDVNKKVLKAFEHGITPIMCCGETLTQREQGVTMDFIRQQVKVGFQGVTADQAKTAVIAYEPIWAIGTGKTATTEQAQEVCAGIRACIAEIYDEATAEAIRIQYGGSVNPATAPDLFVQNDIDGGLVGGASLKADFGKIVNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L6X7</accession>
    <name>A0A174L6X7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">ruvA</name>
        <name evidence="12" type="ORF">BWLFYP14_00982</name>
        <name evidence="10" type="ORF">ERS852478_01496</name>
        <name evidence="11" type="ORF">ERS852523_00783</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">2789STDY5834863</strain>
            <strain evidence="11 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RuvA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP17309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380995.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1351"/>
    <dbReference type="EnsemblBacteria" id="CUN96064">
        <property type="protein sequence ID" value="CUN96064"/>
        <property type="gene ID" value="ERS852478_01496"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17309">
        <property type="protein sequence ID" value="CUP17309"/>
        <property type="gene ID" value="ERS852523_00783"/>
    </dbReference>
    <dbReference type="GeneID" id="66492606"/>
    <dbReference type="eggNOG" id="COG0632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN96064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP17309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX63496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="202" mass="21704" checksum="BC9767115D5FE1BD" modified="2016-09-07" version="1">MIAFVHGMAVDMTESSVVVEAGGIGYEIYMTGADLSEIRMGEDVKVHTYFSVREDAMKLYGFRAKDDLQMFKLLLGVNGVGPKAALGVLAGITADELRFAILSDDVKTLSKAPGIGKKTAQKLILELKDKMKLEDAFELKLAHEQERAAVGAGEVSDGRQEAVEALVALGYSSADALRAVRKVTDVPPDDVEGLLKAALKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174N7P6</accession>
    <name>A0A174N7P6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Catabolite control protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ccpA_1</name>
        <name evidence="5" type="synonym">ccpA_2</name>
        <name evidence="5" type="ORF">ERS852478_00377</name>
        <name evidence="6" type="ORF">ERS852523_01566</name>
        <name evidence="8" type="ORF">GT712_06055</name>
        <name evidence="7" type="ORF">GT728_06445</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
            <strain evidence="6 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">BIOML-A1</strain>
            <strain evidence="8 11">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000013">
        <property type="protein sequence ID" value="CUP42115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000011">
        <property type="protein sequence ID" value="MZL32850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000009">
        <property type="protein sequence ID" value="MZS88661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380667.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000060_gene474"/>
    <dbReference type="EnsemblBacteria" id="CUN52738">
        <property type="protein sequence ID" value="CUN52738"/>
        <property type="gene ID" value="ERS852478_00377"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP42115">
        <property type="protein sequence ID" value="CUP42115"/>
        <property type="gene ID" value="ERS852523_01566"/>
    </dbReference>
    <dbReference type="GeneID" id="66496007"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN52738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP42115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL32850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS88661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="341" mass="39374" checksum="6A1B916BC747E5E2" modified="2016-09-07" version="1">MSKKQVTFADIAAYTHFSKTTISRYFNHPDSLTLENQEKISQALDILGYKKNKLAKVLANGKSEFIGIIIPNLYLHYYSEMLTQLLSSYSDYHYKFLVFSSEHGAEEEQQYIEELLSYQIEGLIVLSHTLSSKQLSSYQIPIVAIEREAEYISSVTTDNYMGALQATTLLIRDKCDILIHINVNVEKTVPAYDRIRAFKETCEEYQVPYDIDLSVSGNSYQEILNEIRRIFTRIEEKYPNQKKGIFLSNDTYANMFLNLIFQKYRELPSFYEIIGFDNSPIASEAILPITTVGQQIDIIAQTAMELLVQQMEEQKKRSPKPLEKPVHKQITPILIRRNTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QT61</accession>
    <name>A0A174QT61_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methylphosphotriester-DNA--protein-cysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">adaA_4</name>
        <name evidence="3" type="synonym">adaA_3</name>
        <name evidence="3" type="ORF">ERS852478_01829</name>
        <name evidence="4" type="ORF">ERS852523_02649</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
            <strain evidence="4 6">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000029">
        <property type="protein sequence ID" value="CUP74078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000014_gene1196"/>
    <dbReference type="EnsemblBacteria" id="CUO08918">
        <property type="protein sequence ID" value="CUO08918"/>
        <property type="gene ID" value="ERS852478_01829"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP74078">
        <property type="protein sequence ID" value="CUP74078"/>
        <property type="gene ID" value="ERS852523_02649"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="195"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO08918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP74078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="312" mass="36452" checksum="B9E7465F4FD9E8F9" modified="2016-09-07" version="1">MAKKRKKPKMEFRYYQMPAGSPILALLGQKWVQNYGNDVDYLHFHNYLEIGFCYEGDGVMAFGEAKMRFSGREFTVIPPNYAHTTNSDLGTVSKWEYLFIDVEGFMKKFLNNPVKAEKMIQRIYSKALFLKENESPSIAAKILKIMNIMREGEEFYIEESSGVLAALLVEIARLNRASPEDRVEEETGKLTNMITRVLDFVSYHYMEDIRIEDLAKICHISETHFRRVFTSHMKVSPLEYINSVRIHTACEFLQKTDTPVADIAHKCGFTTNSTFNRNFRQIMGVTPVEWRKRPENYEQQLLDFYIHSEEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SAP9</accession>
    <name>A0A174SAP9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HPr family phosphocarrier protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Phosphocarrier protein HPr</fullName>
            <ecNumber evidence="3">2.7.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ptsH_2</name>
        <name evidence="6" type="synonym">ptsH_1</name>
        <name evidence="6" type="ORF">BWLFYP14_00502</name>
        <name evidence="2" type="ORF">ERS852478_02507</name>
        <name evidence="3" type="ORF">ERS852523_03382</name>
        <name evidence="5" type="ORF">GT712_02320</name>
        <name evidence="4" type="ORF">GT728_13265</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000048">
        <property type="protein sequence ID" value="CUP94843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000033">
        <property type="protein sequence ID" value="MZL34145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000004">
        <property type="protein sequence ID" value="VUX62615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703704.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000026_gene984"/>
    <dbReference type="EnsemblBacteria" id="CUO33431">
        <property type="protein sequence ID" value="CUO33431"/>
        <property type="gene ID" value="ERS852478_02507"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP94843">
        <property type="protein sequence ID" value="CUP94843"/>
        <property type="gene ID" value="ERS852523_03382"/>
    </dbReference>
    <dbReference type="GeneID" id="66495258"/>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO33431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP94843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS87957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX62615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="85" mass="9474" checksum="CDC342204696B920" modified="2016-09-07" version="1">MVSFTYIIKDKFGIHARPGLLLVQEAGKLTSNITIFKGTDSGDAKRMFCVMNLAVKQGDQITVHVEGENEEADAEVMREFLKNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174T768</accession>
    <name>A0A174T768_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03695</name>
        <name evidence="3" type="ORF">ERS852523_03759</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO72117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000063">
        <property type="protein sequence ID" value="CUQ04926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002323370.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000117.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72117">
        <property type="protein sequence ID" value="CUO72117"/>
        <property type="gene ID" value="ERS852478_03695"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ04926">
        <property type="protein sequence ID" value="CUQ04926"/>
        <property type="gene ID" value="ERS852523_03759"/>
    </dbReference>
    <dbReference type="GeneID" id="15230405"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024760">
        <property type="entry name" value="HTH_dom_conjug_TS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12645">
        <property type="entry name" value="HTH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_16" evidence="1">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ04926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="82" mass="9571" checksum="AE1886B8CBE0C285" modified="2016-09-07" version="1">MKHTMKKPSYYLLSQAMDGDEKAIEKILAFYDPYISKCCLRPLYDEYGNVYIVVDMELKGLIREALIKMILGFDIALEIEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WMI8</accession>
    <name>A0A173WMI8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00007</name>
        <name evidence="3" type="ORF">GT712_07865</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN40819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008702980.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000089.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN40819">
        <property type="protein sequence ID" value="CUN40819"/>
        <property type="gene ID" value="ERS852478_00007"/>
    </dbReference>
    <dbReference type="GeneID" id="66492924"/>
    <dbReference type="eggNOG" id="COG3314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN40819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS88988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="308" mass="33873" checksum="A3FABBF1A0542819" modified="2016-09-07" version="1">MSKNTILTGGICFLLVFLLLHPAESLSCARAGMTLWLNTLIPTLLPFIILTGMLTHTGHIRKLLLPFESFFHIFPGVSIWGGYVFVLGMLCGYPLGAKLASDLYGLHKISKKEALYLTTFCNNPSPAFIITYLCKSCLKDTVPAGMVFASIFSANLICILFFRFFVYQNATISDSPGFSPEISSRKNILDFSIMNGFETITRLGGYILLFSILAGCIRYYAPFPLLYQYLLLGFTEITSGLSLISVSGLPYMTRILLSAATTASGGLCILAQTKGVLHHDLSILPYFISKCICTFLTAGILYCLISYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WP73</accession>
    <name>A0A173WP73_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199471.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41332">
        <property type="protein sequence ID" value="CUN41332"/>
        <property type="gene ID" value="ERS852478_00022"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008014803" evidence="2">
        <location>
            <begin position="28"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN41332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="339" mass="36591" checksum="A9B9EB69A74CF914" modified="2016-09-07" version="1">MKKRSFTLLMSALTISATLIGTSPVAAKTDTDTATEETTDKEETTAKDADSENTDNKETDASKGDTLEDGTYTAEFDTDSGMFHVNEANDGKGTLTVKDGKMTIHVSLASKKIVNLFVGKAEDAQKDGAEILEPTTDTVTYSDGMSEEVYGFDIPVPAIDEEFDVALIGTKGKWYDHKVSVKNPVKSDDTDAKKDDKENKDADSKADDTDKDAKDSKTSEGKTLADLNLEDGDYTMDVTLTGGSGRATIDSPAAIKVEGDKATATIVWSSPNYDYMLVDGEKYEPVNKDGNSTFEIPVSVFDAEMEVTADTVAMSEPHEIDYTLNFDSTTAKEAEKTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WRI2</accession>
    <name>A0A173WRI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron hydrogenase 1</fullName>
            <ecNumber evidence="9">1.12.7.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852478_00050</name>
        <name evidence="10" type="ORF">ERS852523_00717</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
            <strain evidence="10 12">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.12.7.2" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP15576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055149631.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1414"/>
    <dbReference type="EnsemblBacteria" id="CUN42189">
        <property type="protein sequence ID" value="CUN42189"/>
        <property type="gene ID" value="ERS852478_00050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15576">
        <property type="protein sequence ID" value="CUP15576"/>
        <property type="gene ID" value="ERS852523_00717"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003149">
        <property type="entry name" value="Fe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036991">
        <property type="entry name" value="Fe_hydrogenase_ssu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013352">
        <property type="entry name" value="Fe_hydrogenase_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02256">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12837">
        <property type="entry name" value="Fer4_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00902">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02512">
        <property type="entry name" value="FeFe_hydrog_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="8">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN42189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP15576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="562" mass="61963" checksum="8C4D6C9A64A73F60" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WWR4</accession>
    <name>A0A173WWR4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell division protein SepF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">sepF</name>
        <name evidence="7" type="ORF">ERS852478_00108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Localizes to the division site, in a FtsZ-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SepF family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059755.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43933">
        <property type="protein sequence ID" value="CUN43933"/>
        <property type="gene ID" value="ERS852478_00108"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01197">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023052">
        <property type="entry name" value="Cell_div_SepF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007561">
        <property type="entry name" value="Cell_div_SepF/SepF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038594">
        <property type="entry name" value="SepF-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35798">
        <property type="entry name" value="PTHR35798"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04472">
        <property type="entry name" value="SepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0717">Septation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN43933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="219" mass="24254" checksum="A82902A1E19EF18D" modified="2016-09-07" version="1">MGVLDKFLDAIKLNDDYDDDGFLDDDLLDEEEDDDFLDDDFDEKPKKKFFDKFSKKKESDDNDDFDDVEEKTVKTVPKQASAPKQTASAPSKVTVKQERAERQTRPAASSKITPMRSSRKSNQGPNMEVCVIKPSSMEDTREIADTLVDNSTVILNLEGIDVELAQRIIDFTSGACYSLGGSLQKVSSYIFVLGPYNVDITGDLQNILGGSAPSVRAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X3P1</accession>
    <name>A0A173X3P1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pyruvate formate-lyase-activating enzyme</fullName>
            <ecNumber evidence="12">1.97.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pflA</name>
        <name evidence="16" type="ORF">BWLFYP14_02677</name>
        <name evidence="14" type="ORF">ERS852478_00180</name>
        <name evidence="15" type="ORF">GT728_06090</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="15 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 19">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[formate C-acetyltransferase] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:19225"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12190"/>
            <dbReference type="Rhea" id="RHEA-COMP:12191"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
            <dbReference type="EC" id="1.97.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-[protein] + reduced [flavodoxin] + S-adenosyl-L-methionine = 5'-deoxyadenosine + glycin-2-yl radical-[protein] + H(+) + L-methionine + semiquinone [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:61976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:14480"/>
            <dbReference type="Rhea" id="RHEA-COMP:15993"/>
            <dbReference type="Rhea" id="RHEA-COMP:15994"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29947"/>
            <dbReference type="ChEBI" id="CHEBI:32722"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:140311"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.97.1.4" evidence="12"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381418.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45766">
        <property type="protein sequence ID" value="CUN45766"/>
        <property type="gene ID" value="ERS852478_00180"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043365">
        <property type="term" value="F:[formate-C-acetyltransferase]-activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012839">
        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012838">
        <property type="entry name" value="PFL1_activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02493">
        <property type="entry name" value="PFLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN45766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL32787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VUX66305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="246" mass="28082" checksum="A0305642986E1100" modified="2016-09-07" version="1">MDNKQIKGYVHSLESFGSVDGPGVRYVIFLSGCAMRCQFCHNPDTWKMKQGELYTADELLKKALRYKGYWGSKGGITVSGGEPLLQMDFLTEFFKKAKAEGVHTNLDTSGNPFTDQEPWHSGWLELMKYTDLVMLDIKQIDEQEHIKLTGHSNKNILAMARELSDMKKPVWIRHVLVPDGSDKDEYLHRLADFIHTLSNVERVEVLPYHTLGKFKWENLGLSYPLEGVNPPTQERIDNARKILGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X682</accession>
    <name>A0A173X682_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bifunctional xylanase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_00231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN47211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199512.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN47211">
        <property type="protein sequence ID" value="CUN47211"/>
        <property type="gene ID" value="ERS852478_00231"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018337">
        <property type="entry name" value="Cell_wall/Cho-bd_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01473">
        <property type="entry name" value="Choline_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19127">
        <property type="entry name" value="Choline_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51170">
        <property type="entry name" value="CW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015224" evidence="4">
        <location>
            <begin position="40"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="Cell wall-binding" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="Cell wall-binding" evidence="2">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="5">
        <location>
            <begin position="215"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN47211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="411" mass="44705" checksum="F637FE6573FA0BC7" modified="2016-09-07" version="1">MSEHLPRTNRWLIALSVILCLILGGIFTRSSAVTSQADAISDAGAFVSEDQDSAEFTSEETLTDSNDNFTDSSSGKLFGRTSSDSSETSPGGPALSTDISPEASDGSWASSGSNWMFLVDDKPYTGWFTDTDGKQYYMDETGIMQTGWTDIGKKRYYFDMDGILQTGTVIIDKKTYELDTDGSLKGYTPKKKSSKKKSSDKSATSDKSGTSTAKKSVALTFDDGPSSFTGRLLDCLEENNAKATFFMVGTEIASFPDEVKRMKKLGCELGNHTYDHKDLATLSSDEISSEIARVDEQLVNLTGEGASVVRPPYGSVNDTVKSTVGTPMILWSIDTLDWKTQDVESTVEEVMNNVKDGSIILMHDIFSTSVDAAEILIPQLIKEGYQLVTVHELASLHQTELSAGVTYGEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XC52</accession>
    <name>A0A173XC52_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative HTH-type transcriptional regulator ywnA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ywnA_1</name>
        <name evidence="2" type="synonym">ywnA_2</name>
        <name evidence="1" type="ORF">ERS852478_00267</name>
        <name evidence="2" type="ORF">ERS852523_04469</name>
        <name evidence="3" type="ORF">GT712_15870</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000128">
        <property type="protein sequence ID" value="CUQ23346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000040">
        <property type="protein sequence ID" value="MZS90503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052657.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49352">
        <property type="protein sequence ID" value="CUN49352"/>
        <property type="gene ID" value="ERS852478_00267"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ23346">
        <property type="protein sequence ID" value="CUQ23346"/>
        <property type="gene ID" value="ERS852523_04469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN49352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUQ23346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="145" mass="16311" checksum="AFACA932E96170B4" modified="2016-09-07" version="1">MKYSTKLSDTIHILIFIALGDDEQLSSTKIAESIKTNPAYVRQLMATLKNAGIVVNTQGHANAALAKSADKINMYDIYRAVEGDKPLLHLDTDTNPDCGIGINIQFAIGDFYHEIQNMVDEKMKSITLQDIIDRYYFKIRKVKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XH26</accession>
    <name>A0A173XH26_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-aminopeptidase/D-esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199566.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50994">
        <property type="protein sequence ID" value="CUN50994"/>
        <property type="gene ID" value="ERS852478_00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN50994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="304" mass="31805" checksum="26F886133016D0BA" modified="2016-09-07" version="1">MSLLKEISITELTNLRIGHASDHDGQTGVTVLYFPQGAKVGCDISDNPINAIVLSGGSAYGLAAADGVMNYLESQNVGYNTGAALVPLVCQSCIYDLSYGNPKVRPTAKMGEEACLQAFFGTDARTGNIGAGTGATVGRLYGMKQSMKSGLGIAAVSAGDFQMTAVVIVNALGDTFNPQNGLKIAGLKTPDRSGFLDSVQELYRFMTPHDQFTGNTTIGAVITNGAFSKAELNKIASMTRCAYARCINSVATMADGDSIYAASIGDVPVDINMAGTLAAEVMAQAIQNAIHTSQIPDEEFLKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XJZ2</accession>
    <name>A0A173XJZ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain-fatty-acid--CoA ligase FadD15</fullName>
            <ecNumber evidence="2">6.2.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.2.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381332.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52161">
        <property type="protein sequence ID" value="CUN52161"/>
        <property type="gene ID" value="ERS852478_00357"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN52161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="514" mass="56957" checksum="B30CD0528BA35B44" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XKP7</accession>
    <name>A0A173XKP7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anaerobic benzoate catabolism transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00359</name>
        <name evidence="4" type="ORF">GT712_05985</name>
        <name evidence="3" type="ORF">GT728_06525</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000011">
        <property type="protein sequence ID" value="MZL32865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000009">
        <property type="protein sequence ID" value="MZS88648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706728.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52219">
        <property type="protein sequence ID" value="CUN52219"/>
        <property type="gene ID" value="ERS852478_00359"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN52219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="92" mass="10644" checksum="F197A0B4D643522D" modified="2016-09-07" version="1">MEQFVWETAEELDQKLAQRVRNIRKRRSISQEKLSSMSGVSYGSIKRFETTGQISLISLTKIAMALDIADELRNIFTHVPYKDIQEVINEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XLI7</accession>
    <name>A0A173XLI7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable sensor-like histidine kinase YehU</fullName>
            <ecNumber evidence="7">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yehU_2</name>
        <name evidence="8" type="synonym">yehU_3</name>
        <name evidence="7" type="ORF">ERS852478_00370</name>
        <name evidence="8" type="ORF">ERS852523_01559</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
            <strain evidence="8 10">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000013">
        <property type="protein sequence ID" value="CUP41948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055150789.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000060_gene481"/>
    <dbReference type="EnsemblBacteria" id="CUN52539">
        <property type="protein sequence ID" value="CUN52539"/>
        <property type="gene ID" value="ERS852478_00370"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP41948">
        <property type="protein sequence ID" value="CUP41948"/>
        <property type="gene ID" value="ERS852523_01559"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="321"/>
        </location>
    </feature>
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            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN52539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP41948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="594" mass="68436" checksum="45D41D623DCECF8E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XMP2</accession>
    <name>A0A173XMP2_9FIRM</name>
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        <submittedName>
            <fullName evidence="2">CarD-like/TRCF domain</fullName>
        </submittedName>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUN52994.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="171" mass="20053" checksum="F39AD7DD06EC2D71" modified="2016-09-07" version="1">MKYEIGDFVSKPVTGICKIENILYLNPQDEKNDKLYYLMKPVEDEKEKIYVPVSSSDSRLRLCLTKEEAWNLIKRIPDIPTAWTNNEKMREQNYKEAVRANNPEALVAIIKMIYQRKQKRLAQGKKCTATDARYFQIAENLLYMELGVALEKPKQEICKTIIDYINQNKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XRA7</accession>
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        </submittedName>
    </protein>
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    </gene>
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            <taxon>Blautia</taxon>
        </lineage>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53800">
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        <property type="gene ID" value="ERS852478_00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CUN53800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="125" mass="14587" checksum="665FFB326038F615" modified="2016-09-07" version="1">MKGEQMSLLHEFVAVRQPTNKKILYSENIYEYINGGKIKKSVVLEIPDDVIQKILYDTHGKLLPDIKFNQWGISVYEKDELIKWLDFLKNVSEEVSKESKQYCQALLDFAMQSYVNNDVVLHFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XS13</accession>
    <name>A0A173XS13_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein of uncharacterized function (DUF2807)</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
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            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54732">
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        <property type="gene ID" value="ERS852478_00444"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="142"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN54732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="322" mass="35423" checksum="3AA8A1A7485CDF48" modified="2016-09-07" version="1">MKKFTKGMLIAAGIFGAVGIGLTAAGGVMGASMSELTGVKSLKRVLLVADGDYDYDDSDDYDDDDDYDDYDYDDSDDYDSDDYDDSDDCDDSEDYARAVDENEEDGTVYQLKYQPTKLDIELKYDELILEEGDSFCVRVYDDSGKNVTVKESSDTLKVRSTKKLSKNRKVCISYPEDVKLQELEIEMGAGTVYLNRDIETEKLSVEMGAGEFESKNPVTAREADLEIGTGSMTFADLSARKTDGECGLGELDLTLTGTQEDYNYDLECGVGNLDVGSDSYSGLGREKTISNKGADRKLDLECGMGNISVDFSGKEHRDLQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XY63</accession>
    <name>A0A173XY63_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">2-keto-3-deoxygluconate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">kdgT</name>
        <name evidence="10" type="ORF">ERS852478_00463</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KdgT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199646.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56210">
        <property type="protein sequence ID" value="CUN56210"/>
        <property type="gene ID" value="ERS852478_00463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015649">
        <property type="term" value="F:2-keto-3-deoxygluconate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004684">
        <property type="entry name" value="2keto-3dGluconate_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03812">
        <property type="entry name" value="KdgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN56210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="316" mass="32596" checksum="BD047BF10D1300BF" modified="2016-09-07" version="1">MIMKFLQKVPAGLMLVPLLIGAVIHTLFPQALEIGGLTTAAFSNAGAATCMGLQLFCLGTTLQLKDMPAVLKRGGTLLLSKFLIGAILGIVVGKVFGQVGFWGLTALSIVAGVTNSNGSLYLSLVKTYGDEADAATVALLALNDGPFFTLLALGASGMASIPMMSLVAVIVPMVLGMIIGNVDKSMMEFFAPMADILIPFVGLTLGAGINLKDVVKGGPQGILLGLITVFVGGFFTLLFDRLICKQPGYAAFAVASTAGNSVAVPAAVVLIDKTWAPYQAVATTQLAASVVVTAILVPIVTSIWAKKYGCPQLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y104</accession>
    <name>A0A173Y104_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative agmatine deiminase</fullName>
            <ecNumber evidence="2">3.5.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Agmatine iminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">aguA</name>
        <name evidence="3" type="ORF">ERS852478_00514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>agmatine + H2O = N-carbamoylputrescine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:18037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:58318"/>
            <dbReference type="EC" id="3.5.3.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the agmatine deiminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.12" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199690.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57912">
        <property type="protein sequence ID" value="CUN57912"/>
        <property type="gene ID" value="ERS852478_00514"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047632">
        <property type="term" value="F:agmatine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01841">
        <property type="entry name" value="Agmatine_deimin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017754">
        <property type="entry name" value="Agmatine_deiminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="PTHR31377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03380">
        <property type="entry name" value="agmatine_aguA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="2">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN57912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="367" mass="41290" checksum="30FAADF291FE8C4B" modified="2016-09-07" version="1">MEVTEKNRTKYRMPGEFEPHEGCVMIWPERPGSWNYGAREAQKAFVKVAEAIGESEKVYMLVSQAQMENAKNQLGNVSGVTLLECETDDAWARDVGATMVLDEKGAVCGVDWQFNAWGGDFDGLYRNWEKDDRVAAFICRTLGCPCLDARPFVLEGGSIHSDGEGTLIVTEACLLSQGRNPQMSREQIEEQLKYWLGVHKIIWLPCGIYQDETNEHVDNVCAFVRPGEVVLAWTEDETDPQYAMSLADLKVLEQETDAKGRKFKIHKLPIPQKPVCLTREDVDGFVFEEGEDEREAGERMAASYVNFYISNGGIILPQFGDENDKRAVEILQKCFPERRIYPIDARAIIVGGGNIHCITQQIPGKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y196</accession>
    <name>A0A173Y196_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020437299.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58002">
        <property type="protein sequence ID" value="CUN58002"/>
        <property type="gene ID" value="ERS852478_00516"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032ZK1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012963">
        <property type="entry name" value="DUF1700"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08006">
        <property type="entry name" value="DUF1700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN58002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="153" mass="17454" checksum="114237D207F2C535" modified="2016-09-07" version="1">MNRKEFLEILRSQLAGQMQEGKAAAHIRYYEDYIQSQVRGGRSEQEVLQELGDPHLIAKTLIDTDDGSTQEDYGEYSSYGSSYGNETELPHQQEKRWKKVIDLSTWHGRAVVIAAAAVIIVLLILIIGVAIPFFIILAIILYFLSWLKKRNDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y7J7</accession>
    <name>A0A173Y7J7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199712.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59530">
        <property type="protein sequence ID" value="CUN59530"/>
        <property type="gene ID" value="ERS852478_00568"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015976" evidence="1">
        <location>
            <begin position="27"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN59530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1139" mass="122433" checksum="18550DD08A0A87C6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YAE9</accession>
    <name>A0A173YAE9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH-quinone oxidoreductase subunit 1</fullName>
            <ecNumber evidence="13">1.6.5.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nqo1_2</name>
        <name evidence="13" type="ORF">ERS852478_00573</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="13"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706191.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59698">
        <property type="protein sequence ID" value="CUN59698"/>
        <property type="gene ID" value="ERS852478_00573"/>
    </dbReference>
    <dbReference type="GeneID" id="66493117"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="568"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="598"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN59698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="625" mass="67802" checksum="3FBF6B57501E7EE0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YG58</accession>
    <name>A0A173YG58_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">uppP_2</name>
        <name evidence="14" type="synonym">uppP</name>
        <name evidence="15" type="ORF">ERS852478_00643</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN62116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN62116">
        <property type="protein sequence ID" value="CUN62116"/>
        <property type="gene ID" value="ERS852478_00643"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUN62116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="338" mass="38257" checksum="CDD86C3B1226E739" modified="2016-09-07" version="1">MWVFCITYYLAETCLIRLKIVVNKNNNKKENRKGKIMDFIELLKVIFLGIVEGITEWLPISSTGHMILVDEFLKLNVTEDFKNLFFVVIQLGAILAVVVLYWNKLWPFYIRPISKKQQAVLNRHGAVSRGILTFVEKFCDKEKWVLWFKIIVACIPTIVIALPFNDVIEEKFNNYVVVAIALIVYGILFIVIENYNKRRRPTCTNLENLSFKTAFIIGLFQVLSVVPGTSRSGSTIIGGILAGTSRTVAAEFTFFLGIPVMFGASLLKILKFGFSFTGTEVMILIVGMVVAFVVSIIAIKFLMGYIKKHDFKAFGWYRIALGILVLGYFIGKTLLGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YK54</accession>
    <name>A0A173YK54_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alpha-galactosidase</fullName>
            <ecNumber evidence="2 5">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rafA_1</name>
        <name evidence="9" type="ORF">ERS852478_00668</name>
        <name evidence="10" type="ORF">GT712_03350</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2 5"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN63950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199748.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63950">
        <property type="protein sequence ID" value="CUN63950"/>
        <property type="gene ID" value="ERS852478_00668"/>
    </dbReference>
    <dbReference type="GeneID" id="66493440"/>
    <dbReference type="eggNOG" id="COG3345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031705">
        <property type="entry name" value="Glyco_hydro_36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16874">
        <property type="entry name" value="Glyco_hydro_36C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_36N" evidence="8">
        <location>
            <begin position="31"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_36C" evidence="7">
        <location>
            <begin position="653"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN63950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS88149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="733" mass="84174" checksum="E78CB3667D0E62E5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YMH2</accession>
    <name>A0A173YMH2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF624 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Predicted integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00669</name>
        <name evidence="3" type="ORF">GT712_03345</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN63988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199749.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63988">
        <property type="protein sequence ID" value="CUN63988"/>
        <property type="gene ID" value="ERS852478_00669"/>
    </dbReference>
    <dbReference type="GeneID" id="66493441"/>
    <dbReference type="eggNOG" id="COG5578">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006938">
        <property type="entry name" value="DUF624"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04854">
        <property type="entry name" value="DUF624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN63988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS88148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="221" mass="25331" checksum="AC181633ABD3FA1B" modified="2016-09-07" version="1">MKPGSLYDRIFGFLGQLIALNLLWIVCSLPVITAGASTTALYYCTLKLHKDGDIRVFHDFFKSFKQNFKQSTLIWILMAAVAVFLYMEKESLVTMPGSMPQIFNYVILAVCIPLIAIALYIFPTVAAFENKTMTLITNAFYFAVKHIGYAIAVAVITILPMTMTLVDAKLFPVYLLIWLMVGFSLTAYADSWFMWKLFKPYFKEDEEEHHYVDTEPDQYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YTK6</accession>
    <name>A0A173YTK6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dapF_1</name>
        <name evidence="8" type="synonym">dapF</name>
        <name evidence="11" type="ORF">BWLFYP14_01772</name>
        <name evidence="10" type="ORF">ERS852478_00749</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052695.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000086.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66747">
        <property type="protein sequence ID" value="CUN66747"/>
        <property type="gene ID" value="ERS852478_00749"/>
    </dbReference>
    <dbReference type="GeneID" id="66493524"/>
    <dbReference type="eggNOG" id="COG0253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="221"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN66747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX64970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="283" mass="30993" checksum="4A21214FE70872F8" modified="2016-09-07" version="1">MKFTKMHGIGNDYVYVNCFEETVENPSAVARYVSDRHFGIGSDGLILIKPSKIADCEMDMYNLDGSQGAMCGNGIRCVAKYAYDYGIVNKEHISVATKSGIKYLDLTVENGKVSQVKVNMGSPILTARQIPVVSEKEEVINEPLDVNGKIYYITAVSMGNPHAIVYMDDIDHLDIEKIGPAFENHVAFPDRVNTEFVEVIDEHTVKMRVWERGSGETLACGTGACAVAVASVLNGHVDGDSPVTVKLLGGDLQIFWNRQENLVYMTGPAATVFDGEIDVSFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YZJ8</accession>
    <name>A0A173YZJ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00831</name>
        <name evidence="3" type="ORF">ERS852523_03030</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000037">
        <property type="protein sequence ID" value="CUP84992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059016.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69612">
        <property type="protein sequence ID" value="CUN69612"/>
        <property type="gene ID" value="ERS852478_00831"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP84992">
        <property type="protein sequence ID" value="CUP84992"/>
        <property type="gene ID" value="ERS852523_03030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014250790" evidence="1">
        <location>
            <begin position="33"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN69612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP84992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="159" mass="17499" checksum="85DAB2A15044DB93" modified="2016-09-07" version="1">MKTWTKKFQKMLTLILAICLVTGCMGFSNVQAATGKSGTTYYDTCINGKKGGTITTNGTKYYMSGTRKAICKGNTLTMYASFNTSKNGILNSQNKKAYIKYGKHTFKLTSKTKYYFSGGEAPNDYCSKSAFMSTMRSMNGLGLRIKVTNGKVVEMSFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZBJ8</accession>
    <name>A0A173ZBJ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit b</fullName>
            <shortName evidence="11">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpF_1</name>
        <name evidence="11 15" type="synonym">atpF</name>
        <name evidence="17" type="ORF">BWLFYP14_01288</name>
        <name evidence="13" type="ORF">ERS852478_00915</name>
        <name evidence="14" type="ORF">ERS852523_01118</name>
        <name evidence="16" type="ORF">GT712_08215</name>
        <name evidence="15" type="ORF">GT728_01260</name>
    </gene>
    <organism evidence="13 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 18">2789STDY5834863</strain>
            <strain evidence="14 19">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="15 21 22" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 22">BIOML-A1</strain>
            <strain evidence="16 21">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="17 20" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="10 11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000009">
        <property type="protein sequence ID" value="CUP28350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS89054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993266.1">
        <property type="nucleotide sequence ID" value="NZ_JADPEC010000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000124_gene3951"/>
    <dbReference type="EnsemblBacteria" id="CUN73039">
        <property type="protein sequence ID" value="CUN73039"/>
        <property type="gene ID" value="ERS852478_00915"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP28350">
        <property type="protein sequence ID" value="CUP28350"/>
        <property type="gene ID" value="ERS852523_01118"/>
    </dbReference>
    <dbReference type="GeneID" id="66493031"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN73039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUP28350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL31860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZS89054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VUX64209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="166" mass="18708" checksum="BE936127548C32C0" modified="2016-09-07" version="1">MIEININLVFTIINLIVLYLLMKKFLFGPILNVMEQRKNMIDQQFASAKDTEEQAYELKGKYEDALKSAKDESMRIVNQAKDEAKVQAERIVKDANTQAGAMLDKAKADIRTEQENAMKAMESRVAEIALDAASKIMGEKNSSQQDLSLYDQFIKEAGDSNDGNKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZCD7</accession>
    <name>A0A173ZCD7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Choloylglycine hydrolase</fullName>
            <ecNumber evidence="4">3.5.1.24</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Linear amide C-N hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cbh_1</name>
        <name evidence="5" type="synonym">cbh</name>
        <name evidence="8" type="ORF">BWLFYP14_01281</name>
        <name evidence="4" type="ORF">ERS852478_00908</name>
        <name evidence="5" type="ORF">ERS852523_01110</name>
        <name evidence="7" type="ORF">GT712_08180</name>
        <name evidence="6" type="ORF">GT728_01225</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">2789STDY5834863</strain>
            <strain evidence="5 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 13">BIOML-A1</strain>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C59 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.24" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000009">
        <property type="protein sequence ID" value="CUP28132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS89047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706993.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000023_gene1768"/>
    <dbReference type="EnsemblBacteria" id="CUN72815">
        <property type="protein sequence ID" value="CUN72815"/>
        <property type="gene ID" value="ERS852478_00908"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP28132">
        <property type="protein sequence ID" value="CUP28132"/>
        <property type="gene ID" value="ERS852523_01110"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045302">
        <property type="term" value="F:choloylglycine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBAH" evidence="3">
        <location>
            <begin position="2"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN72815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP28132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL31853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS89047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX64195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="325" mass="36635" checksum="FD93B941690E53CE" modified="2016-09-07" version="1">MCTAATYKTKDFYFGRTLDYEFSYGDEITITPRNYPFHFRHSDKAPDSHYAIIGMAHVAGDYPLYYDAINEKGLGMAGLNFVGNAVYAEPVSDKENVAQFEFIPWILSQCATLKEARQRLSTMNLTNTQFSENFPCAQLHWILADASGCLVIESMQDGLHIYENPVGVLTNNPPFPQQMFQLNNYQSLSPRQPENTFAPGLELQSYSRGMGALGLPGDLSSASRFAKVAFTKMNSRSGDSELESVSQFFHILGSVDQQRGCCEVAKGKYEITLYTSCCNTTKGIYYYTTYENHQINAVDMHRENLDTTVLIRYPVLAKQNICFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZEH6</accession>
    <name>A0A173ZEH6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_00935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199850.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73608">
        <property type="protein sequence ID" value="CUN73608"/>
        <property type="gene ID" value="ERS852478_00935"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="4">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN73608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="152" mass="17454" checksum="4EA255723B077664" modified="2016-09-07" version="1">MKKIGIISDTHGLLRPEILGILKGCDCIIHAGDVNKPEILDTLRMMGSIYVVRGNNDKDWAEGMAKTLHFTIEGVKFFMTHNKKDVDWDLKDTQVVIFGHTHKYFEKMIDNRLWLNPGSCGPRRFDQEITMAVMTVDNGTYQWEKVAMIPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZTC9</accession>
    <name>A0A173ZTC9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PadR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator PadR-like family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, Acidobacterial, PadR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_00333</name>
        <name evidence="2" type="ORF">ERS852478_01053</name>
        <name evidence="4" type="ORF">GT712_13680</name>
        <name evidence="3" type="ORF">GT728_14350</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000037">
        <property type="protein sequence ID" value="MZL34348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000028">
        <property type="protein sequence ID" value="MZS90094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579216.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78458">
        <property type="protein sequence ID" value="CUN78458"/>
        <property type="gene ID" value="ERS852478_01053"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN78458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX67488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="105" mass="12155" checksum="4A0312269AFD9B6D" modified="2016-09-07" version="1">MYFPVSALLIEYMILSVVESRDSYGYEISQTVKKAADIKESTLYPILKKLQSAGYLTTYSQEYQGRKRKYYSLTEEGKAQIAYLSNEWQIYKDTVDGIIEGRIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A460</accession>
    <name>A0A174A460_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrolipoamide dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052481.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83401">
        <property type="protein sequence ID" value="CUN83401"/>
        <property type="gene ID" value="ERS852478_01193"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028348">
        <property type="entry name" value="FAD-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038984">
        <property type="entry name" value="FAD_binding_protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN83401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="456" mass="50578" checksum="1E098EBB70BD9115" modified="2016-09-07" version="1">MKYDVVIIGAGPGGIFSAYELMKQNNDLKIAVFEAGNPLSKRHCPIDGDKVKTCIKCKTCAIMSGFGGAGAFSDGKYNITNDFGGTLYEHIGKKDALDLMRYVDEINVAYGGQDTKMYSTAGTKFKKLCMQNKLKLLDASVRHLGTDINYVVLENLYAKLKEHVDFHFNTPVERLEVLEDRYRIITKNDTTDCSKCIVSVGRSGSKWMEQICKELDIPTKSNRVDLGVRVELPAVIFSHLTDELYESKIVYRTEKFEDNVRTFCMNPYGIVVNENTNGIVTANGHSYEDPSKQTENTNFALLVAKHFSEPFKDSNGYGESIARLSNMLGGGVIVQRFGDLVRGRRSTVARIEEGMVRPTLAATPGDLSLVLPKRILDGIIEMIYALDKIAPGTANDDTLLYGVEVKFYNMEVDIDENLESRYKGLYIIGDGSGVTHSLSHASASGVYVARQIIENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A7S9</accession>
    <name>A0A174A7S9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="3 12">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">mutY</name>
        <name evidence="14" type="ORF">ERS852478_01201</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Adenine glycosylase active on G-A mispairs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="3 12"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199957.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83830">
        <property type="protein sequence ID" value="CUN83830"/>
        <property type="gene ID" value="ERS852478_01201"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03431">
        <property type="entry name" value="DNA_Glycosylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005760">
        <property type="entry name" value="A/G_AdeGlyc_MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029119">
        <property type="entry name" value="MutY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14815">
        <property type="entry name" value="NUDIX_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01084">
        <property type="entry name" value="mutY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 12 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="13">
        <location>
            <begin position="38"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN83830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="353" mass="40278" checksum="70B2CC256C0F90BC" modified="2016-09-07" version="1">MVLEEIVQPLVKWYRDNKRILPWRDKDNAYYTWVSEIMLQQTRVEAVKPYFQRFITELPDIQSLAECPEEKLLKLWEGLGYYNRVRNMQEAAKTVKDEYNGRLPEDYQALLSLKGIGSYTAGAIASIAYGKKVPAVDGNVLRVISRITESTEDISRQSVRRKIEQQVSQIMPSDCPGDFNQALMELGAVICVPNGQAKCAECPIAFTCLAHRHDKADMIPVKAPKKARTQDNRTVFIIQDGECTAIRKRPEKGLLAGLYELPNTQGHLKSEDALLYVKELGLDPLYIEELPPAKHIFSHIEWRMQAYRIKVSSLKTTQDKELIFVSKEQSGKQYAIPSAFGAYAKYIKEETTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ABQ5</accession>
    <name>A0A174ABQ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sortase, SrtB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006857253.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86041">
        <property type="protein sequence ID" value="CUN86041"/>
        <property type="gene ID" value="ERS852478_01235"/>
    </dbReference>
    <dbReference type="GeneID" id="61431735"/>
    <dbReference type="eggNOG" id="COG4509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05826">
        <property type="entry name" value="Sortase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009835">
        <property type="entry name" value="SrtB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015986">
        <property type="entry name" value="SrtB_Firmicute"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030150">
        <property type="entry name" value="UCP030150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03064">
        <property type="entry name" value="sortase_srtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stablizer" evidence="3">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR030150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR030150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN86041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="257" mass="29230" checksum="5D2F618DF87B1F41" modified="2016-09-07" version="1">MKNYKSIICVAAAVCLLGTAAFCGFRIYHHYAQVDEQTEAFEEIAEMVEQAPTEETMPDDAPVSEGEDVLAKYQELYLQNEDMVGWLSIAGTIINYPVMQSRNNPNFYLKHNFEKEYSDLGTPYVQENCDIAESDNLVIYGHHIKGGKMFGALEDYKSKSFYEEHKNIQFDTLTEQEEYEIVAVFKTVAYSSEGFRYYDFVDAENEEDFNSYVGKCKELALYDTGVTAEYGDRLITLSTCEYSAQNGRLVVVAKKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AGC8</accession>
    <name>A0A174AGC8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852478_01260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199992.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPB010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86969">
        <property type="protein sequence ID" value="CUN86969"/>
        <property type="gene ID" value="ERS852478_01260"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN86969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="406" mass="43761" checksum="30355717BA2E7109" modified="2016-09-07" version="1">MFAKNSKAYSVYLLFRFVSSLAVSMSTVLSIVYHLEVVQLDAFQLVLVGTVQETACFLFEIPTGVVSDLYSRRRSVLIGMFLYGLGFLMEGALPWFAPVLLAQVVWGCGDTFITGALEAWIASEEKDKPIDKVFLRGSQMGQIGGVLGVVPGTLLGNINLQMPVILGGSLCLLLGLVLVRIMPETNFSPAIEERQGLLKDFVCLFKLNLGFVKGAPVLLALLAITLCGGLASEGFDRLSTAHFLDDTVIPVIGPLNSVTWFGVISLIGSGLGILASQLLIARMEKKGTVSRTSVVMSTSAGYILCLVLFAVGRSFWFMLLVFLLAGLMRTIKEPVLAAWMNDHVDEKMRATVFSTSGQLDSFGQIIGGPIVGLVAQQVSIPWGLVCTAFLLLPALFLVPVAGKKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ALV5</accession>
    <name>A0A174ALV5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="3 5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">purF_1</name>
        <name evidence="10" type="synonym">purF_2</name>
        <name evidence="13" type="ORF">BWLFYP14_01657</name>
        <name evidence="9" type="ORF">ERS852478_01317</name>
        <name evidence="10" type="ORF">ERS852523_00909</name>
        <name evidence="12" type="ORF">GT712_09490</name>
        <name evidence="11" type="ORF">GT728_08145</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 5"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000007">
        <property type="protein sequence ID" value="CUP21186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000015">
        <property type="protein sequence ID" value="MZL33171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705709.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000047_gene1256"/>
    <dbReference type="EnsemblBacteria" id="CUN88899">
        <property type="protein sequence ID" value="CUN88899"/>
        <property type="gene ID" value="ERS852478_01317"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21186">
        <property type="protein sequence ID" value="CUP21186"/>
        <property type="gene ID" value="ERS852523_00909"/>
    </dbReference>
    <dbReference type="GeneID" id="66494925"/>
    <dbReference type="eggNOG" id="COG0034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN88899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP21186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL33171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS89296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX64801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="471" mass="52734" checksum="0312249613253770" modified="2016-09-07" version="1">MGGIFGVASKSSCILDLFFGIDYHSHLGTRRGGMAVYDKKRGFDRVIHNIENAPFRTKFDGDIGEMEGNLGIGCISDNEPQPLLVRSHLGNFAITTVGKINNMDELIANCFKNGCTHFLEMSGGSVNPTEMVAALINQKDNMIEGIRYAQEVIEGSMTMLILTPKGILAARDRLGRTPLIVGKKEDACCVSFESFAYLNLGYEDLKELGPGEIVAVTPDGVETLQKPGEEMRICSFLWVYYGYPTSAYEGVNVEEMRYHCGDMLARRDRGEVNPDIVAGVPDSGIAHAIGYANQSGVPFARPFIKYTPTWPRSFMPTQQSQRNLIARMKLIPVHRLIKDKSLLMIDDSIVRGTQLRETTEFLYRNGAKEVHIRPACPPLLYGCKYLNFSRSKSEMDLITRRVIAKREGENVSDKVLADYADPNSTNYKEMLEEIRKELNFTSLKFHRLDDLKASIGISPCKLCTYCWDGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AMX9</accession>
    <name>A0A174AMX9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ppk_1</name>
        <name evidence="6" type="synonym">ppk</name>
        <name evidence="12" type="ORF">ERS852478_01353</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200028.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90111">
        <property type="protein sequence ID" value="CUN90111"/>
        <property type="gene ID" value="ERS852478_01353"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="9">
        <location>
            <begin position="18"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="8">
        <location>
            <begin position="132"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="11">
        <location>
            <begin position="342"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="10">
        <location>
            <begin position="512"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="601"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN90111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="702" mass="80866" checksum="7767557A2215F845" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B1Z8</accession>
    <name>A0A174B1Z8_9FIRM</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">ERS852478_01470</name>
    </gene>
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        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN95121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="107" mass="12467" checksum="E1D0130A19D547ED" modified="2016-09-07" version="1">MKKRLKKIVTTVKKVGTLNLVLMFVGAFFIWFNWQMILLYRQCDSMPETYACAVVAATIGECGICGWIRTNKDKQQDRKWQKQDEKEGREQNDSDMNVGNIDEEDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BDG6</accession>
    <name>A0A174BDG6_9FIRM</name>
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        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">ERS852478_01540</name>
    </gene>
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        <name type="scientific">Blautia wexlerae</name>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProt"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="124"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN97706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="186" mass="21744" checksum="123ABC6E1078D3DE" modified="2016-09-07" version="1">MIDDEKIIEMFFGRSEQGIRELDIKYGKVCHNLSYHIVGSRQDAEECVNDAYLGAWNAIPPARPNPLLSYLVKIVRNISLKIYWRKEAAKRSSHYTIALEEIEACIAAPNTVEAEIEAKELARIIEAFLDTLTTENRVIFMRRYWFSDSYKDIAEFMGLSEKNISVRLTRIREKMKQYLIEREVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BL10</accession>
    <name>A0A174BL10_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved hypothetical integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057325.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01243">
        <property type="protein sequence ID" value="CUO01243"/>
        <property type="gene ID" value="ERS852478_01616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011733">
        <property type="entry name" value="CHP02185_IM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09605">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02185">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO01243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="193" mass="21270" checksum="BFC4BC00F81A93C3" modified="2016-09-07" version="1">MNNKLQGKDLINIGIFTAIYFIVIFAAASIGFIPIFIPLISVIVPLVGGIPMMLFFSKIKKFGMLTICGVLLGIIMLLTGMGYWCIPTGLIFGLIADFMLKACDYKNAKREVLTHGVFSMWVIGAFIPIVVTRDAYYQSLLPGYGKEYADTLMAYMPDWILPILLAASFVSGIVGGLIGQKIFRKHFERAGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BM68</accession>
    <name>A0A174BM68_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02132">
        <property type="protein sequence ID" value="CUO02132"/>
        <property type="gene ID" value="ERS852478_01644"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO02132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="74" mass="8360" checksum="4A6C1DA913ECA644" modified="2016-09-07" version="1">MGVINSPLVEGRVFSEEVNKKEVTVNGANSNKKSVRITIILHTLFAIISLLLYIVSYTVLCDLKITFLYFRRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BSU9</accession>
    <name>A0A174BSU9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rplD</name>
        <name evidence="11" type="ORF">BWLFYP14_00256</name>
        <name evidence="8" type="ORF">ERS852478_01658</name>
        <name evidence="9" type="ORF">ERS852523_01294</name>
        <name evidence="10" type="ORF">GT728_04695</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">2789STDY5834863</strain>
            <strain evidence="9 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707249.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2983"/>
    <dbReference type="EnsemblBacteria" id="CUO02626">
        <property type="protein sequence ID" value="CUO02626"/>
        <property type="gene ID" value="ERS852478_01658"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33664">
        <property type="protein sequence ID" value="CUP33664"/>
        <property type="gene ID" value="ERS852523_01294"/>
    </dbReference>
    <dbReference type="GeneID" id="66496121"/>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO02626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP33664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL32517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX67415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="206" mass="22510" checksum="3A98C7465665DC8F" modified="2016-09-07" version="1">MANVTVYNMEGNEVGTMELNDAVFGVEVNEHLVHLAVVRQLANNRQGTQKAKTRSEVSGGGRKPWRQKGTGHARQGSIRAPQWTGGGVVFAPVPRDYEVKMNKKERRAALKSALTSKVQDNKLVVVDALTLADVKTKEMQKVLTNLKAEKALVITATDDKNVILSARNITDVQTATPSTINVYDVMNHNTVIVTKDAVASIEEVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BU27</accession>
    <name>A0A174BU27_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">rplR</name>
        <name evidence="12" type="ORF">BWLFYP14_00271</name>
        <name evidence="8" type="ORF">ERS852478_01673</name>
        <name evidence="9" type="ORF">ERS852523_01279</name>
        <name evidence="11" type="ORF">GT712_08910</name>
        <name evidence="10" type="ORF">GT728_04770</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707271.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2968"/>
    <dbReference type="EnsemblBacteria" id="CUO03128">
        <property type="protein sequence ID" value="CUO03128"/>
        <property type="gene ID" value="ERS852478_01673"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33172">
        <property type="protein sequence ID" value="CUP33172"/>
        <property type="gene ID" value="ERS852523_01279"/>
    </dbReference>
    <dbReference type="GeneID" id="66496136"/>
    <dbReference type="eggNOG" id="COG0256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO03128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP33172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL32532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS89187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX67430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="122" mass="13331" checksum="34AF7CAD1068367F" modified="2016-09-07" version="1">MVNKASRAKIRENKHRRLRHHLNGTATTPRLAVFRSNKHIYAQIIDDTVGKTLVSASTLQKEVRAELENTDDVAAAAHLGTVIGKKAVEAGIESVVFDRGGYIYHGKVKALADAAREAGLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BVN0</accession>
    <name>A0A174BVN0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380653.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03710">
        <property type="protein sequence ID" value="CUO03710"/>
        <property type="gene ID" value="ERS852478_01689"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO03710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="213" mass="24164" checksum="85B3E3B876AADDB9" modified="2016-09-07" version="1">MAKSCNQKGKILYLQKMLSETTSQNPVTMQEILAKLEEQGIRAERKSIYDDMETLRDFGMDIHYRRGREGGYYEEKSASDKTEADNTIIHQPDGETGEKSENVQEQIGKESEAPAKISAPTPSQTGENIKEIRLVCQNSTKKKIQRTFGSEIFCKIKGEDNFIVTVEVVVDKAFFGWLTSMGRNVHILKPKKAAVAYRDYLKNIAKDYKGIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CAK6</accession>
    <name>A0A174CAK6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic di-GMP phosphodiesterase Gmr</fullName>
            <ecNumber evidence="3">3.1.4.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gmr_1</name>
        <name evidence="3" type="ORF">ERS852478_01824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.52" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08768">
        <property type="protein sequence ID" value="CUO08768"/>
        <property type="gene ID" value="ERS852478_01824"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071111">
        <property type="term" value="F:cyclic-guanylate-specific phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="224"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO08768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="579" mass="66358" checksum="40FF91AEA37A9B6E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CE71</accession>
    <name>A0A174CE71_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic di-GMP phosphodiesterase Gmr</fullName>
            <ecNumber evidence="2">3.1.4.52</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gmr_2</name>
        <name evidence="2" type="ORF">ERS852478_01879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.4.52" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11187">
        <property type="protein sequence ID" value="CUO11187"/>
        <property type="gene ID" value="ERS852478_01879"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071111">
        <property type="term" value="F:cyclic-guanylate-specific phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="38"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO11187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="165" mass="18809" checksum="86116A5DF5274DAC" modified="2016-09-07" version="1">MAMQNRLLEQKAFIDAYTGLPNKNACNELLNKKDIITDPTACIMFDLNNLKTVNDTMGHSAGDQLILNFAKLLRSVIPEKDFVGRYGGDEFIAVIYHTSEAEIKVILKSLYREKNRLNSYENQIPIDYACGWALSSDDMSGTMQMLLDEADAYMYKNKQLCKKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CF54</accession>
    <name>A0A174CF54_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP pyrophosphokinase ywaC</fullName>
            <ecNumber evidence="4">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ywaC_2</name>
        <name evidence="4" type="ORF">ERS852478_01869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200390.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10889">
        <property type="protein sequence ID" value="CUO10889"/>
        <property type="gene ID" value="ERS852478_01869"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="3">
        <location>
            <begin position="70"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO10889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="223" mass="25979" checksum="475580511DE13850" modified="2016-09-07" version="1">MSENLFGLTVAADKGLDDLQCQRLLSENRRYQEVMLQYRCALKALESRLEILNEEFSLQHDRNPIESIKSRLKSPSSIMNKMQKRGLSLDFPTMQANIMDIAGVRVICSFEEDVFFMAKCLKKQSDIEIITEKDYISHPKPNGYRSLHLTIRLPVFFAEKEIHVSVEIQLRTIAMDFWASLEHTIRYKKNLPINAEVETELKECADSSREWDSKMEHLLHILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CHR1</accession>
    <name>A0A174CHR1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tagatose-6-phosphate kinase</fullName>
            <ecNumber evidence="2">2.7.1.144</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lacC</name>
        <name evidence="4" type="ORF">ERS852478_01931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + D-tagatofuranose 6-phosphate = ADP + D-tagatofuranose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12420"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58694"/>
            <dbReference type="ChEBI" id="CHEBI:58695"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.144"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; D-tagatose 6-phosphate degradation; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase PfkB family. LacC subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.144" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200448.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12872">
        <property type="protein sequence ID" value="CUO12872"/>
        <property type="gene ID" value="ERS852478_01931"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00704">
        <property type="reaction ID" value="UER00715"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008662">
        <property type="term" value="F:1-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009024">
        <property type="term" value="F:tagatose-6-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001059">
        <property type="term" value="P:D-tagatose 6-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005988">
        <property type="term" value="P:lactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022463">
        <property type="entry name" value="1-PFruKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03828">
        <property type="entry name" value="pfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0423">Lactose metabolism</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="25"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO12872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="303" mass="32845" checksum="6ECED7BB4B52C54F" modified="2016-09-07" version="1">MIYTVTFNPSLDYIVSVDDFKLGLTNRTSSELMLPGGKGINVSTVLMNLGIENTALGFAAGFVGEEIIRRLHEMGVKSEFIRISEGVSRINLKLKSIDGTEINGAGPMISKDKVEELMKKLEELGEGDVLFLAGSIPSSMPDDMYEQIMARLDGKGVMIVVDATKDLLVNVLKYHPFLVKPNNHELGEIFGVELKTRKDVIPYGKKLQEKGARNVLISMAGEGAVLIAEDGQVFEEPAPKGRLVNGVGAGDSMVAGFVAGWMEKKDYEHAFHMGIAAGSASAFSENLATKEEIEAVYGQITEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CJQ0</accession>
    <name>A0A174CJQ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sigF_3</name>
        <name evidence="10" type="synonym">sigG</name>
        <name evidence="11" type="ORF">BWLFYP14_02222</name>
        <name evidence="9" type="ORF">ERS852478_01908</name>
        <name evidence="10" type="ORF">GT728_10795</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000023">
        <property type="protein sequence ID" value="MZL33673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703529.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12028">
        <property type="protein sequence ID" value="CUO12028"/>
        <property type="gene ID" value="ERS852478_01908"/>
    </dbReference>
    <dbReference type="GeneID" id="66493886"/>
    <dbReference type="eggNOG" id="COG1191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="217"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO12028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL33673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX65857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="259" mass="30043" checksum="06AB94B4F83E2870" modified="2016-09-07" version="1">MALNKVEICGVNTSKLPVLTAEEKAELFRRIKNGDEQARELYIKGNLRLVLSVIRRFQNSSENADDLFQIGCIGLIKAIDNFDTTLQVKFSTYAVPMIIGEIRRYLRDNNSIRVSRSLRDIAYKAIYTRENYMKQHLKEPTVTEIAQEIGIEKEMIVYALDAIQNPVSLFEPVYTEGGDTLYVMDQISDKKNKEERWIENLALREAMQRLNSREKHIIELRFYEGKTQMEVAQEIGISQAQVSRLEKNALKSMRNYLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CR55</accession>
    <name>A0A174CR55_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfbD</name>
        <name evidence="4" type="ORF">ERS852478_01992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707537.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15497">
        <property type="protein sequence ID" value="CUO15497"/>
        <property type="gene ID" value="ERS852478_01992"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000095431">
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        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="RmlD-like-bd"/>
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    <dbReference type="PANTHER" id="PTHR10491">
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO15497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="313" mass="34716" checksum="DE215E447974AED3" modified="2016-09-07" version="1">MRIFVTGVGGQLGHDVMNELAKRGYEGVGSDIAPSYSGIADGTAVTTMPYVQMDITDKASVEKVIKEANVDAVIHCAAWTAVDAAEDEENQPKVRLVNVTGTQNIADVCKELDIKMLYLSTDYVFDGQGTTPWEPDCKDYKPLNVYGQTKLDGELAVSGTVNKFFIVRIAWVFGKNGKNFIKTMINLGKTHDTLSVVNDQIGTPTYTYDLARLLIDMIETEKYGYYHATNEGGYISWYDFTKEIFRQAAAMGHPEYLPENMTVNSVTTAEYGASKAARPFNSRLDKSKLTANGFTPLPTWQDALGRYLKELDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CVL8</accession>
    <name>A0A174CVL8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 13" type="primary">era</name>
        <name evidence="13" type="ORF">ERS852478_02004</name>
        <name evidence="14" type="ORF">ERS852523_00078</name>
        <name evidence="16" type="ORF">GT712_10285</name>
        <name evidence="15" type="ORF">GT728_08910</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">2789STDY5834863</strain>
            <strain evidence="14 18">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="15 19 20" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 20">BIOML-A1</strain>
            <strain evidence="16 19">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9 10">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO96216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000018">
        <property type="protein sequence ID" value="MZS89446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707556.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2244"/>
    <dbReference type="EnsemblBacteria" id="CUO15870">
        <property type="protein sequence ID" value="CUO15870"/>
        <property type="gene ID" value="ERS852478_02004"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96216">
        <property type="protein sequence ID" value="CUO96216"/>
        <property type="gene ID" value="ERS852523_00078"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="12">
        <location>
            <begin position="6"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="192"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="9">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="9">
        <location>
            <begin position="40"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="9">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="9">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="9">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO15870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO96216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL33312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZS89446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="302" mass="34057" checksum="1DADDB81468F8ABE" modified="2016-09-07" version="1">MNENFKSGFVAIIGRPNVGKSTLMNHLIGQKIAITSKKPQTTRNRIQTVYTCDEGQIVFLDTPGIHKAKNKLGEYMVQVAERTLKEVDAIMWLVEPSTFIGAGERHIAEQLQGIGVPVILIINKIDTVSKEEILPAIDTYRKVCDFAEIIPCSALRGQNTQDIIGCILKYLPYGPMFYDEDTVTDQPQRQIVAEIIREKALHALDAEIPHGIAVAIDRMKTRPGKNPIVDIDATIICERESHKGIIIGKQGAMLKKIGSNARYEIERMLESKVNLKLWVKVKKDWRDSDFLIKNFGYDKKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CXS9</accession>
    <name>A0A174CXS9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amino acid adenylation domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Gramicidin S synthase 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Gramicidin S synthase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grsB</name>
        <name evidence="6" type="ORF">BWLFYP14_02363</name>
        <name evidence="3" type="ORF">ERS852478_02082</name>
        <name evidence="5" type="ORF">GT712_14215</name>
        <name evidence="4" type="ORF">GT728_13915</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">BIOML-A1</strain>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO18321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000035">
        <property type="protein sequence ID" value="MZL34269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000030">
        <property type="protein sequence ID" value="MZS90192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707690.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18321">
        <property type="protein sequence ID" value="CUO18321"/>
        <property type="gene ID" value="ERS852478_02082"/>
    </dbReference>
    <dbReference type="GeneID" id="66493756"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="402"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO18321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="491" mass="54416" checksum="D1F672483ED70587" modified="2016-09-07" version="1">MDTIYSLFQKVVKEHENAPAIIENDRAMTFGELSNMVDMITCSFPQEVHSIGIVMRHRTEMIASILAVLKCGGQYVPAEPDFPTGRIHDMMTEAQVDFVLTEHAFAPKLSSFPIRYTDCEICGVETPSWKRNAIEDPERPAYVLYTSGTTGRPKGVCVTNRNVCHYVRAFANEFHPGPGDVMLQYSVCSFDIFVEEVFTSLLNGAALAIPADEDKADIHALMAFVERHHVTMISGFPYLLAEMNHLSVIPSSLRLLISGGDVLRGVYVDHLLNKAEVYNTYGPSETTVCASYYRCNSGTVLEDGTYPIGHPVLGAQIRILDQSGNEVAKGQTGEICIYGGGVSLGYIGDHAEENSAFERQPDGSTMYRSGDLGYILPNGNIAFLHRKDDQIMIYGKRVELAEVESRLYRCKDVQQAIVRAFTDEDGLSYMTAYVVPSDNKLKVSEVKKELSENLTSFMIPEFFVKMKQIPLNVNGKPDVSKLPVVMKAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CZD5</accession>
    <name>A0A174CZD5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="8">6.3.2.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fgs_2</name>
        <name evidence="8" type="ORF">ERS852478_02043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200513.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17118">
        <property type="protein sequence ID" value="CUO17118"/>
        <property type="gene ID" value="ERS852478_02043"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="7">
        <location>
            <begin position="45"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="6">
        <location>
            <begin position="291"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO17118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="427" mass="47222" checksum="0C7632D301B107BB" modified="2016-09-07" version="1">MNYQESREYIDKITREIPSVLGLDHMRELMKRLGNPQDDLKYVHIAGTNGKGSVIAFLYSVLSGAGYRIGRYVSPTLYSYRGRMEVSGSRISREDFAAYITQVSDVIAAMTKDGYPHPTAFEIETAVAFLFFKKENCDLVLLEVGMGGNLDATNIIKNTLLAVLVSISMDHMSFLGNTLAQIAEKKAGIIKDGCRVVTARQKPEAMQVIERISREHGAKCTIADASEAEVLKESCFGQTIRYRGEEYEIPLAGVYQKENAVVALNALKVLDELGFPTAAEQKKEGLRTVNWNGRFTVICKKPLFVVDGAHNPAAADMMAASIEHYFKGKRIIYIMGVFADKDYRSVIQKTAHFADRILTIQTPDNIRALPAGELAKTVSEYNPNVQAMDTIKDAVEEAFSLAGEQDVIIAFGSLSFIGEMTDIVENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D0X3</accession>
    <name>A0A174D0X3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc metalloprotease</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rasP</name>
        <name evidence="11" type="ORF">ERS852478_02061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200529.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17690">
        <property type="protein sequence ID" value="CUO17690"/>
        <property type="gene ID" value="ERS852478_02061"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00054">
        <property type="entry name" value="TIGR00054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="182"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO17690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="431" mass="47328" checksum="8744D9CDD5CB6816" modified="2016-09-07" version="1">MKIIIAIVIFSAIILFHELGHFLFAKLNKIVVTEFSLGMGPRLFSFEKGDTRYSLKLLPIGGSCAMLGEDTDIENEPGTFNSASVWGRISVVAAGPVFNFIMAFVLSVIIVGAVGYEPSRVLSVKEGSAAEAAGLKEGDIITGYQGYHIDLGKDLYVYSYLNQLKEGDTINLTVKRDGKKMDISYKSDTNVRYLLGCNFNGDDTSAMTVESVMDGMPLQEAGIRQGDVITSINGVKITNAADYQKYIQENPLTEKSVKLTYSRDGQEYDITVTPKEYRTAESGFTYNMYSEKAKGLNVVKYGAVEVKYMVRTTILSLKELVSGKLGMKDLSGPVGVVDAIGTTYEESKSEGTMILWMNMLNMAVLLSANLGVMNLLPFPALDGGRLVFLVIEAIRRKPINRQVEGGIHFAGLMLLMALMVFVMYNDIVKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DAH3</accession>
    <name>A0A174DAH3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF3789)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21025">
        <property type="protein sequence ID" value="CUO21025"/>
        <property type="gene ID" value="ERS852478_02148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024522">
        <property type="entry name" value="DUF3789"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12664">
        <property type="entry name" value="DUF3789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO21025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="44" mass="4932" checksum="1A14C769FC83AF5F" modified="2016-09-07" version="1">MQRLLFDFLLFSLGGTVGVIAMCILQAGRQSDRKMMELKGEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DAT2</accession>
    <name>A0A174DAT2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200585.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21180">
        <property type="protein sequence ID" value="CUO21180"/>
        <property type="gene ID" value="ERS852478_02152"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041895">
        <property type="entry name" value="ArdA_dom1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO21180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="131" mass="15218" checksum="5D4C3F63F1FDE23C" modified="2016-09-07" version="1">MAEMKVFVINLDEQEKDTGCAWFTLPCNIEALKQSIGLPPDSDRYLISDYDFPFEILQDTDLDLLNNICLAISESEIPPEDIPAIQREWFSNLQELEAGLCNITYHRNCSDMEETSEHFLCVHGRFYEYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DEJ2</accession>
    <name>A0A174DEJ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GntR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">HTH-type transcriptional repressor YtrA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transcriptional regulatory protein PtsJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ytrA_3</name>
        <name evidence="4" type="ORF">BWLFYP14_01474</name>
        <name evidence="2" type="ORF">ERS852478_02222</name>
        <name evidence="3" type="ORF">GT712_11605</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO23873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000022">
        <property type="protein sequence ID" value="MZS89700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993363.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23873">
        <property type="protein sequence ID" value="CUO23873"/>
        <property type="gene ID" value="ERS852478_02222"/>
    </dbReference>
    <dbReference type="GeneID" id="66495141"/>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO23873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS89700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="125" mass="14217" checksum="31E0A0F83CE7CD74" modified="2016-09-07" version="1">MMIEIDFSSDEAIYIQLTNQIIMGIATSRLQEGDTLPSVRQLADTVGINMHTVNKAYSLLRQEGFVTIDRRRGAVISIDVNKRKALEELKQNLMVALAKGCCKSVSREEVHQLIDEIFDEYDENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DF07</accession>
    <name>A0A174DF07_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4 7">GTP pyrophosphokinase YwaC</fullName>
            <ecNumber evidence="4 7">2.7.6.5</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="6">GTP pyrophosphokinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ywaC_4</name>
        <name evidence="5" type="synonym">ywaC_1</name>
        <name evidence="7" type="ORF">BWLFYP14_02856</name>
        <name evidence="4" type="ORF">ERS852478_02195</name>
        <name evidence="5" type="ORF">ERS852523_01703</name>
        <name evidence="6" type="ORF">GT712_11345</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">2789STDY5834863</strain>
            <strain evidence="5 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="4 7"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000015">
        <property type="protein sequence ID" value="CUP46599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993340.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000021_gene1703"/>
    <dbReference type="EnsemblBacteria" id="CUO22506">
        <property type="protein sequence ID" value="CUO22506"/>
        <property type="gene ID" value="ERS852478_02195"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP46599">
        <property type="protein sequence ID" value="CUP46599"/>
        <property type="gene ID" value="ERS852523_01703"/>
    </dbReference>
    <dbReference type="GeneID" id="66493387"/>
    <dbReference type="eggNOG" id="COG2357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="3">
        <location>
            <begin position="56"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO22506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP46599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS89650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="218" mass="25742" checksum="33E43B67BBDFE9CF" modified="2016-09-07" version="1">MNYDSVPLRDFKELNDWETVIFVYQSALKQVETKIDILNGEFQHRHKYNPIEHVKSRIKTPESIVKKLKRHGYESSIENMVRYVNDIAGIRISCSFTSDIYLIADMISKQNDLTILARRDYMKNPKKSGYRSYHMLVTTPVFLSDSIIDTKVEIQIRTVAQDFWATLEHKMHYKFEGDGPDYITKELRECARYVAELDTRMEELNNEIQKYGKLSDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DFW4</accession>
    <name>A0A174DFW4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Int-Tn_3</name>
        <name evidence="9" type="ORF">ERS852478_02240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200627.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24384">
        <property type="protein sequence ID" value="CUO24384"/>
        <property type="gene ID" value="ERS852478_02240"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008907">
        <property type="term" value="F:integrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075713">
        <property type="term" value="P:establishment of integrated proviral latency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044826">
        <property type="term" value="P:viral genome integration into host DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004191">
        <property type="entry name" value="Integrase_Tn916-type_DNA-bd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02920">
        <property type="entry name" value="Integrase_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="SSF54171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0229">DNA integration</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1179">Viral genome integration</keyword>
    <keyword evidence="4" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="8">
        <location>
            <begin position="80"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="7">
        <location>
            <begin position="187"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO24384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="396" mass="45956" checksum="E595B4D0E2ACEEC1" modified="2016-09-07" version="1">MSNVKRKDSKNRNLRNGESQRKDGRYVYKYTDIYGKPQFIYSWKLVPTDKTPAGKRDDISLREKEAQIKKDLNDGIDTVGGKMTVCQLYDKKNSQRKNIKRATEKGRQYLMNALKDDPLGMRAIDTVKQSDAKEWAIRMSEKGYAYKTIDNYKRSLKASFYMAIQDDCIRKNPFEFKLSDVLEDDTEQKVILTPEQEERLLAFMETDKIYSKYYDEVVLLLETGLRISEFCGLTTHIDMQNRILNIDHQLLKDSEIGYYIETPKTKNGKRELPLTERAYQAIQRILKNRGKAQPLIVGGYSNFLFLNREGLPKVAGNYEGMVRGLIKKYNKYHTDKLPNITPHSFRHTYCTNMANRGMNPNTLQYLMGHANITMTLGYYAHGTFQSAKAELERLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DJ71</accession>
    <name>A0A174DJ71_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25652">
        <property type="protein sequence ID" value="CUO25652"/>
        <property type="gene ID" value="ERS852478_02282"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008800">
        <property type="term" value="F:beta-lactamase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030655">
        <property type="term" value="P:beta-lactam antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045155">
        <property type="entry name" value="Beta-lactam_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000871">
        <property type="entry name" value="Beta-lactam_class-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35333">
        <property type="entry name" value="PTHR35333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13354">
        <property type="entry name" value="Beta-lactamase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020049" description="Beta-lactamase2 domain-containing protein" evidence="1">
        <location>
            <begin position="38"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase2" evidence="2">
        <location>
            <begin position="279"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO25652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="497" mass="55172" checksum="EBCF889BC67D7640" modified="2016-09-07" version="1">MRKNRQTAKYYIKSYIIAGSLAGAISMALALAVPVMAAQQSLASVTGQAQIQPMGDGSGKYMMKSDGFYCLDVNGAGSTQAEIHYFQDYEIDGTVFDGYYYHDTDGKFKACSPHIEHLKGVAVFGDKTDEEADTQNAQEAEKFDGYYFVNNLGRLSAAPQVRYIDNLAIDGITLNGYYYFDENGRLVTEPGIHSLEMDCYEMNFDGSYYFGGTNGALLQESTVTDDGFIVDDTGKIVNMDDLGMDNLKPQLEKMLSGYQGTWSVYVKDLNEEKEILINDTSLYSASLIKAFVMAKTYEDMEQVKADEAKKLNTADTKTVDVKLNDLLWNMITVSDNESCNELVKLQTDSLDFKKGAEDINKYLEKEGYTETSVQHTLHPAASAQESLGGRNMTSVKDCGTLLEKIYKGECVSKEASEEMLNLLSNQENTWKIPQGLPNGIKSANKTGETDQDQHDIAIVYGEKTTYILCVMSENCPESTAVTNIQNISKIVYNYLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DMI6</accession>
    <name>A0A174DMI6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BMC domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Carbon dioxide-concentrating mechanism protein CcmK homolog 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ccmK2_3</name>
        <name evidence="4" type="synonym">ccmK2_1</name>
        <name evidence="7" type="ORF">BWLFYP14_01564</name>
        <name evidence="3" type="ORF">ERS852478_02318</name>
        <name evidence="4" type="ORF">ERS852523_01623</name>
        <name evidence="6" type="ORF">GT712_12770</name>
        <name evidence="5" type="ORF">GT728_12265</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP43979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000029">
        <property type="protein sequence ID" value="MZL33953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705582.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000086_gene4005"/>
    <dbReference type="EnsemblBacteria" id="CUO26801">
        <property type="protein sequence ID" value="CUO26801"/>
        <property type="gene ID" value="ERS852478_02318"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP43979">
        <property type="protein sequence ID" value="CUP43979"/>
        <property type="gene ID" value="ERS852523_01623"/>
    </dbReference>
    <dbReference type="GeneID" id="66494435"/>
    <dbReference type="eggNOG" id="ENOG5032ST1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO26801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP43979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL33953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS89920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX64710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="104" mass="10947" checksum="DF6ACE8DB3E45D4B" modified="2016-09-07" version="1">MAEAVGILEVFGLATAFVAGDAGCKAANVRLEVFDKNKPANADSLPVPLLVCIKFRGSVTDVTAAVEAGMEVANRMTGVVQHYVIPNPEEGTEKMLKISALDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E2S4</accession>
    <name>A0A174E2S4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO31994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31994">
        <property type="protein sequence ID" value="CUO31994"/>
        <property type="gene ID" value="ERS852478_02449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO31994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="72" mass="8728" checksum="AA9AD78E577352A6" modified="2016-09-07" version="1">MEKILLAESCIEVYENIEEFLEKSGWRRDNPELCSECYLFENHICRKIQGKIWYFSRIQYENGLRGMKQGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E7X7</accession>
    <name>A0A174E7X7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hisJ_2</name>
        <name evidence="4" type="ORF">BWLFYP14_02143</name>
        <name evidence="3" type="ORF">ERS852478_02477</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703656.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32698">
        <property type="protein sequence ID" value="CUO32698"/>
        <property type="gene ID" value="ERS852478_02477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="2">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO32698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="116" mass="13346" checksum="A7B127E3BEBA3588" modified="2016-09-07" version="1">MHVLYYIFYVKDVYSLENRKLLFTSLGKGYVDAIAAHETSVQQYIKDYGAKIRILDEAILTTGIGVAFPENTDSELPEKLTEIFKEMRKDGSEEKILKKYLPETSGYLEVDKIENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EA07</accession>
    <name>A0A174EA07_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32820">
        <property type="protein sequence ID" value="CUO32820"/>
        <property type="gene ID" value="ERS852478_02482"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033QKY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO32820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="611" mass="68308" checksum="6AF519A07BC7E65D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EB36</accession>
    <name>A0A174EB36_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antirestriction protein (ArdA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO34863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34863">
        <property type="protein sequence ID" value="CUO34863"/>
        <property type="gene ID" value="ERS852478_02540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009899">
        <property type="entry name" value="ArdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041893">
        <property type="entry name" value="ArdA_dom3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07275">
        <property type="entry name" value="ArdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO34863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="160" mass="18738" checksum="41810680024F9BCC" modified="2016-09-07" version="1">METKGTTGEETISYWFDLPIDVAEFEEKLGIGAESGDYLIIEKVVPFADEVHEHTSVYQLNELDFMYRQLSSDMQEEYVSLLTVYENLEALYICRNVITVYPNCKSMIDVARQKLMNDPTFKHLSEDCQAYYFDFEAYASHLLENRRYLVTEHAVFELPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EET3</accession>
    <name>A0A174EET3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative aliphatic sulfonates transport permease protein ssuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ssuC_3</name>
        <name evidence="7" type="ORF">ERS852478_02572</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35857">
        <property type="protein sequence ID" value="CUO35857"/>
        <property type="gene ID" value="ERS852478_02572"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="65"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO35857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="263" mass="29945" checksum="62E1FC67A5498A8C" modified="2016-09-07" version="1">MMHSITNDRAKTDNGTKYTGIRILAVLFWIAIWQFASMYLKQEILLASPVSVVRKLFELIFSGNFWQSVGFSFVRIVTGFLLAVLLGIFLAVWAYWSKTVEILTAPVIAVVKSTPVASFIILCLIWIPSKNLSVFISFLMVLPVIYTNIFEGIRQTDRKILEMAKVFRVNLRRQIRYIYVSQVLPYFLSACRLSLGMCWKAGVAAEVIGVPSGSIGEKLYNAKIYLNTPDLFAWTIVIIVISFVFEKCFLGIVSRVVYMIEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ELF5</accession>
    <name>A0A174ELF5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">rex</name>
        <name evidence="9" type="ORF">ERS852478_02616</name>
        <name evidence="10" type="ORF">ERS852523_00213</name>
        <name evidence="12" type="ORF">GT712_07450</name>
        <name evidence="11" type="ORF">GT728_02850</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">2789STDY5834863</strain>
            <strain evidence="10 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 16">BIOML-A1</strain>
            <strain evidence="12 15">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO37045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000002">
        <property type="protein sequence ID" value="CUP00400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000011">
        <property type="protein sequence ID" value="MZS88906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380002.1">
        <property type="nucleotide sequence ID" value="NZ_JADPEU010000096.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000003_gene1630"/>
    <dbReference type="EnsemblBacteria" id="CUO37045">
        <property type="protein sequence ID" value="CUO37045"/>
        <property type="gene ID" value="ERS852478_02616"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00400">
        <property type="protein sequence ID" value="CUP00400"/>
        <property type="gene ID" value="ERS852523_00213"/>
    </dbReference>
    <dbReference type="GeneID" id="66494098"/>
    <dbReference type="eggNOG" id="COG2344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CoA_binding" evidence="8">
        <location>
            <begin position="80"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="7">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="90"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO37045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP00400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL32158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS88906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="215" mass="24380" checksum="1A4B208F9A070E5C" modified="2016-09-07" version="1">MEAKEISKAVIKRLPRYYRYLGELMEENVERISSNDLSKKMHVTASQIRQDLNNFGGFGQQGYGYNVRYLYTEIGKILGLDTVHPMIILGAGNLGQALANYVDFEKRGFKLVGIFDVNPVLEGIAVRGIEIQMLSDLPLFLKENEVEIAILTLPKNKAKEMAKILIDNGIKAIWNFAHIDLDAPEDVMVENVHLSESLMTLSYNLSEYRKEHEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EP20</accession>
    <name>A0A174EP20_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative TrmH family tRNA/rRNA methyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TrmH family tRNA/rRNA methyltransferase</fullName>
            <ecNumber evidence="2 3">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_00909</name>
        <name evidence="2" type="ORF">ERS852478_02646</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2 3"/>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707796.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38326">
        <property type="protein sequence ID" value="CUO38326"/>
        <property type="gene ID" value="ERS852478_02646"/>
    </dbReference>
    <dbReference type="GeneID" id="66492691"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO38326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX63431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="257" mass="28147" checksum="345E9EB2FFB18778" modified="2016-09-07" version="1">MITSVNNGQVKNIIQLNQKTKARREQGLFVAEGRKMFGEAPRDWISKVYVSEALSGDAELMAQVEKLPYEIVTDSVFRQMSDTQTPQGIMTVLKKPSYIMEDILGGENPLVMILEDLQDPGNAGTILRTGEGAGVSGVLLTKTCVDITNPKVIRSTMGSVYRMPFLYVESVVSLAQELKDRNIRTFAAHLHGKNSYDQESYTGGTAFLIGNEGKGLTDEAADSADCLIRIPMCGKVESLNAAMASGILMYEAARQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ERQ4</accession>
    <name>A0A174ERQ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_00580</name>
        <name evidence="1" type="ORF">ERS852478_02722</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707925.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40822">
        <property type="protein sequence ID" value="CUO40822"/>
        <property type="gene ID" value="ERS852478_02722"/>
    </dbReference>
    <dbReference type="GeneID" id="66493326"/>
    <dbReference type="eggNOG" id="ENOG503498W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO40822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX62802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="66" mass="7598" checksum="A65153A729A78614" modified="2016-09-07" version="1">MRKPLEKELKSYREQGISLYLNGILSNPKTIAKACQIAEGGGYMRDYVEDEKGRIARVDFDFVKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ESF0</accession>
    <name>A0A174ESF0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">rplI</name>
        <name evidence="14" type="ORF">BWLFYP14_00570</name>
        <name evidence="10" type="ORF">ERS852478_02732</name>
        <name evidence="11" type="ORF">ERS852523_02526</name>
        <name evidence="13" type="ORF">GT712_09835</name>
        <name evidence="12" type="ORF">GT728_09570</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">2789STDY5834863</strain>
            <strain evidence="11 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 19">BIOML-A1</strain>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000027">
        <property type="protein sequence ID" value="CUP70576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000019">
        <property type="protein sequence ID" value="MZL33440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000017">
        <property type="protein sequence ID" value="MZS89362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707912.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000058_gene2542"/>
    <dbReference type="EnsemblBacteria" id="CUO41082">
        <property type="protein sequence ID" value="CUO41082"/>
        <property type="gene ID" value="ERS852478_02732"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP70576">
        <property type="protein sequence ID" value="CUP70576"/>
        <property type="gene ID" value="ERS852523_02526"/>
    </dbReference>
    <dbReference type="GeneID" id="66493316"/>
    <dbReference type="eggNOG" id="COG0359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L9_C" evidence="9">
        <location>
            <begin position="63"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO41082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP70576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL33440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS89362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX62792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="148" mass="16315" checksum="B4565922DD0E4886" modified="2016-09-07" version="1">MKVILLEDVKALGKKGQIVNVSDGYARNMILPKKLGLEATPKNLNDLKLQKANEEKVAKEVYEAAQAFAKDLETKEIILTLKTGEGGRTFGSVSSKEISEAAKKQLNLDIDKKKLQLPEPIRTLGVTQVPVRLHPKVTGTLKVWVKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ETJ9</accession>
    <name>A0A174ETJ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">adapter protein MecA 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mecB</name>
        <name evidence="3" type="ORF">BWLFYP14_00579</name>
        <name evidence="2" type="ORF">ERS852478_02723</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993442.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40851">
        <property type="protein sequence ID" value="CUO40851"/>
        <property type="gene ID" value="ERS852478_02723"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038471">
        <property type="entry name" value="MecA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008681">
        <property type="entry name" value="Neg-reg_MecA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39161">
        <property type="entry name" value="PTHR39161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05389">
        <property type="entry name" value="MecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO40851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX62801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="248" mass="28023" checksum="5F74154B611C9A25" modified="2016-09-07" version="1">MKIEKINDNQIRCTLTREDLENHQIRISELAYGTEKAKKLFRDMMQQAQIQFGFEADNIPLMIEAIPVSTESIILIITKVEDPEELDTRFSKFAPFRGNDKTDTLQLDGADNIIDIFQKLYEAKMKSTQTKDGKSAQNTGAKENDDTQVPDVNLIRLYEFDTLDDVIAAAHGLNGYFTGTNTLYKDPADELYKLVLHQSSLSPEDFNRVCNILTEYGQGKAFSLSGEAYLTEHGELISDSALQQLIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ETR7</accession>
    <name>A0A174ETR7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpsF</name>
        <name evidence="10" type="ORF">BWLFYP14_00566</name>
        <name evidence="6" type="ORF">ERS852478_02736</name>
        <name evidence="7" type="ORF">ERS852523_02522</name>
        <name evidence="9" type="ORF">GT712_09855</name>
        <name evidence="8" type="ORF">GT728_09590</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000027">
        <property type="protein sequence ID" value="CUP70474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000019">
        <property type="protein sequence ID" value="MZL33444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000017">
        <property type="protein sequence ID" value="MZS89366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993443.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000058_gene2538"/>
    <dbReference type="EnsemblBacteria" id="CUO41194">
        <property type="protein sequence ID" value="CUO41194"/>
        <property type="gene ID" value="ERS852478_02736"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP70474">
        <property type="protein sequence ID" value="CUP70474"/>
        <property type="gene ID" value="ERS852523_02522"/>
    </dbReference>
    <dbReference type="GeneID" id="66493312"/>
    <dbReference type="eggNOG" id="COG0360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO41194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP70474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL33444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX62788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="95" mass="11178" checksum="0F1F6FBDA530E606" modified="2016-09-07" version="1">MNKYELALVVSAKVEDEVRDAVVEKAKGYITRYNGTITEVEEWGKKKLAYEIQKMHEGFYYFIQFEADAQCPAEVERHVRIMDNVLRYLVVRKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EU02</accession>
    <name>A0A174EU02_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative sporulation-specific glycosylase ydhD</fullName>
            <ecNumber evidence="4">3.2.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ydhD</name>
        <name evidence="4" type="ORF">ERS852478_02721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200864.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40797">
        <property type="protein sequence ID" value="CUO40797"/>
        <property type="gene ID" value="ERS852478_02721"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00287">
        <property type="entry name" value="SH3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="2">
        <location>
            <begin position="155"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="3">
        <location>
            <begin position="239"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO40797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="549" mass="61859" checksum="F83809ABDEFA327E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F2Z0</accession>
    <name>A0A174F2Z0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IMPACT family member yigZ</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">YigZ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yigZ</name>
        <name evidence="4" type="ORF">ERS852478_02837</name>
        <name evidence="6" type="ORF">GT712_17605</name>
        <name evidence="5" type="ORF">GT728_14485</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">BIOML-A1</strain>
            <strain evidence="6 8">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000038">
        <property type="protein sequence ID" value="MZL34374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000052">
        <property type="protein sequence ID" value="MZS90824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705884.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44593">
        <property type="protein sequence ID" value="CUO44593"/>
        <property type="gene ID" value="ERS852478_02837"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015796">
        <property type="entry name" value="Impact_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09186">
        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00257">
        <property type="entry name" value="IMPACT_YIGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="19"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1949" evidence="3">
        <location>
            <begin position="141"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO44593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL34374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS90824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="218" mass="24354" checksum="44C74C8B3C731F88" modified="2016-09-07" version="1">MLEKYKTVYEGGEGEIVEKKSRFIATVRPVQTEEEALAFIEEMKKKYWDARHNCYVYSVGKNREYTRCSDDGEPSGTAGRPMLDVILGEDIYNVAAVVTRYFGGILLGTGGLVRAYSRSLQEGLAASTVIEKTYGISMEVVTDYTGIGKIQYIAGEQKLPILDSEYTDRVVLHLLVPADQIAFVEKAITEGTNGRAKMKKEKDLYYSVIDGEVKVFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F3N3</accession>
    <name>A0A174F3N3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_01073</name>
        <name evidence="1" type="ORF">ERS852478_02779</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42785">
        <property type="protein sequence ID" value="CUO42785"/>
        <property type="gene ID" value="ERS852478_02779"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO42785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX63715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="37" mass="4117" checksum="FFF6209E9D679DA3" modified="2016-09-07" version="1">MFEAGLFVETFLPLFILSAYKNSVHCKSIVILVNNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F5H0</accession>
    <name>A0A174F5H0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_02827</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO44066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44066">
        <property type="protein sequence ID" value="CUO44066"/>
        <property type="gene ID" value="ERS852478_02827"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="162"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO44066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="260" mass="30488" checksum="45529256C6C9955C" modified="2016-09-07" version="1">MDQIKQLRIYPPEKGSCKIIVVYEVPDQEELPQNGHELSIDLGLHNLMTCYDSENGKTFILGRKYLELERYFHKKIARVQAQWYGQQSGKGVKHPVTSKHIRKLYKRKQDSVTDYLHKITRYLAEYCREQEITCVVTGDIRNIRREKDLGHRTNQKLHSLPYNRIYIMLEYKLKRYGIRFVKQEESYTSQCSPLSPEVGKRYAEPSKRKERGLYRDGNRTYNADAVGAYNILRKYHSVSGVKRELSVTGLKTPEIIKVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FCV7</accession>
    <name>A0A174FCV7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-L-fucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_02947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO47994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380024.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47994">
        <property type="protein sequence ID" value="CUO47994"/>
        <property type="gene ID" value="ERS852478_02947"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="site" description="May be important for catalysis" evidence="5">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001092-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO47994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="436" mass="50719" checksum="A521A62331FA4D86" modified="2016-09-07" version="1">MYQFNRKEYEERMKWYQDARFGMFIHWGLYSIPARGEWVRSTEEMPEEEYLPFMKEFDARDYNPKQWAKEAKAAGMKYVVLTAKHHDGFCLFDSKYTDYKVTNTPAGRDLIKEYVEALREEGLKVGLYFTLLDWHHPDYPHYGDRIHPMRNHPECSNENRDFSRYIEYMYNQVEEVCTNYGKIDIMWFDFSYDDMRGEKWGATRLIDMVRRLQPGIIIDNRLEVSGEGRGSLYECDPTPYHGDFISPEQIIPPEGICDKEGNPMVWEACFTMNNNWGYCANDHYYKPASMLIKKLVECVSKGGNMILNVGPDAKGKFPKESSAILAEIGRWMDKNHDSIYGCAPAADIPKPDYGRITRNGNKYYVHIYENTLGPLPLIGFDKNKIVKVRALDDGHEVPISTLWVHSDYPDIAFVDLGPDPVLPDPVDYVLEVEMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FKH1</accession>
    <name>A0A174FKH1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cob(I)yrinic acid a,c-diamide adenosyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">btuR</name>
        <name evidence="2" type="ORF">BWLFYP14_03572</name>
        <name evidence="1" type="ORF">ERS852478_02978</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993654.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48970">
        <property type="protein sequence ID" value="CUO48970"/>
        <property type="gene ID" value="ERS852478_02978"/>
    </dbReference>
    <dbReference type="GeneID" id="66493679"/>
    <dbReference type="eggNOG" id="COG2109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adensltrnsf_CobA"/>
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO48970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX67297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="163" mass="18477" checksum="055D1E39356D3DD9" modified="2016-09-07" version="1">MEKEFTEVYCGGGKGKTTLAIGQCLRASAQGKSVIIIQFLKGRERRELDFLEELDNLDIKIFRFEKHDEGYEELNEQEKAEEKTNILNALNFARKVIATQECDFLLLDEILALPDYGITTAEAIGDILKMKDESMHILLTGRTLPDSLRKYADSITTLTTEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FQD6</accession>
    <name>A0A174FQD6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO52434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201117.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52434">
        <property type="protein sequence ID" value="CUO52434"/>
        <property type="gene ID" value="ERS852478_03081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO52434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="84" mass="9577" checksum="43D775CD81B7D5EC" modified="2016-09-07" version="1">MKKPSDFYCCICGQPLNDRQDLFVKIRDNDSEETLRIVPVHSGNCDNTLCKQESAKGNNTNSCFNFYSFGNDKELEKYLVTGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FRQ1</accession>
    <name>A0A174FRQ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Relaxase/Mobilisation nuclease domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO52972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201139.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52972">
        <property type="protein sequence ID" value="CUO52972"/>
        <property type="gene ID" value="ERS852478_03090"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005094">
        <property type="entry name" value="Endonuclease_MobA/VirD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03432">
        <property type="entry name" value="Relaxase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO52972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="449" mass="51018" checksum="343D2A4F700053F3" modified="2016-09-07" version="1">MAVTKIKPIKSTLSKALDYIQNPDKTDGKTLVSSFGCSYETADIEFEYTLSQARQKRNNLAFHLIQSFEPGEVDCEKAHTIGKQLADAATKGQHEYVLTTHIDKGHIHNHIIFCAVNFVDYHKYNSNKRSYYGIRNMSDKLCRENGLSVVVPGKGSKGKSYAEYQAEKTGTSWKGKLKIAVDTLIPQVASFEELLQRLQATGYEIKPGKYISCRAPGQERFTRLKTLGADYAEEAIKERIAGKRTRTAKAPKEQRGVSLLIDIENSIKAQESRGYEQWAKIHNLKLAAKTMNFLTEHQIEQYADLVSRIEEISAENEKTADALKSVEKRLADMAVLMKHVTTYQKTKPVYEAYRRAKDKDAYRTKQESSLILYEAAAKALKASGITKLPNLAAMQEEYGQLQAQKEALYADYGKLKKKVKEYDIIKQNIDRILRLEKEPERGRETERLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FYQ7</accession>
    <name>A0A174FYQ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF2992)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_00687</name>
        <name evidence="1" type="ORF">ERS852478_03150</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO54811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000015">
        <property type="protein sequence ID" value="VUX62938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54811">
        <property type="protein sequence ID" value="CUO54811"/>
        <property type="gene ID" value="ERS852478_03150"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016787">
        <property type="entry name" value="UCP021328"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11208">
        <property type="entry name" value="DUF2992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO54811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX62938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="158" mass="18590" checksum="C2984C8FC0A5F882" modified="2016-09-07" version="1">MSTAFKSSLTILFEAPFWIGLYERTDGGKYEVCKITFGSEPKDYEVYEFLLKNWHKLKFSPPIQAEVSIERKLNPKRMQREIQSQLQDKGVGTKAQQALKLQHEQCKLERKAKSQTHRRRADNTQGKFTCDYRFFFISIYDESLPRPMGKEKNRSWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G051</accession>
    <name>A0A174G051_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">regX3_5</name>
        <name evidence="14" type="synonym">regX3_2</name>
        <name evidence="12" type="synonym">regX3_7</name>
        <name evidence="14" type="ORF">BWLFYP14_00861</name>
        <name evidence="11" type="ORF">ERS852478_03159</name>
        <name evidence="12" type="ORF">ERS852523_03524</name>
        <name evidence="13" type="ORF">GT712_16030</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">2789STDY5834863</strain>
            <strain evidence="12 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="13 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000053">
        <property type="protein sequence ID" value="CUP98820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000041">
        <property type="protein sequence ID" value="MZS90531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000024">
        <property type="protein sequence ID" value="VUX63378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705965.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000114.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000152_gene3982"/>
    <dbReference type="EnsemblBacteria" id="CUO55047">
        <property type="protein sequence ID" value="CUO55047"/>
        <property type="gene ID" value="ERS852478_03159"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP98820">
        <property type="protein sequence ID" value="CUP98820"/>
        <property type="gene ID" value="ERS852523_03524"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="126"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO55047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP98820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS90531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX63378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="228" mass="25685" checksum="683C45E35A24B9D1" modified="2016-09-07" version="1">MSNILLLEDDLSLINGLSFAFKKQGFELNIARTLKEAEELWTDGKYDLLVLDVSLPDGSGFEFCKRVRLTSKVPIIFLTASDEETSIIMGLDIGGDDYITKPFKLGVLVSRINALLRRANSFQAADTELQSNGIKVLLLQGQVFKNGELLDLTAAEYKLLCLFMRNPSMVLTKGQILDKLWDCDGNYIDSSTLTVYMRRLRMKIEDNPSEPQMLLTVRGMGYKWNIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GA76</accession>
    <name>A0A174GA76_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ureH</name>
        <name evidence="3" type="synonym">ureD</name>
        <name evidence="4" type="ORF">ERS852478_03290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UreD family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO59382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59382">
        <property type="protein sequence ID" value="CUO59382"/>
        <property type="gene ID" value="ERS852478_03290"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="PTHR33643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO59382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="286" mass="32500" checksum="83CE3C29FBFF7A4F" modified="2016-09-07" version="1">MDNKFGKISRISACAALKDGRTILEDLSFTAPYKIMMPFEKENGGIQIMPLCASAGIMAGDSQEFSYHVKEGADLEVLSQSFEKIHKMDEGSAARTIEVQVDKNATLYYYPQPVIPFAQSAFDSKMTIHLEDETSRLFLLEIISCGRNAHDERFQYRRFSSKVLLYRGDKLIYRDNTRYEPDKMPMEGIGMYEGYTHMANLFLSKICSRDGENCSQESGTVKSADSAINLELQEKIWQILDEDSEIDGGVTRLTAGDLALRIFGYRAQKLQQVAEKIKKLYETEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GI33</accession>
    <name>A0A174GI33_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="4">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="4">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="4">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">asnS_2</name>
        <name evidence="4" type="synonym">aspS</name>
        <name evidence="6" type="ORF">ERS852478_03328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380269.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000055.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60828">
        <property type="protein sequence ID" value="CUO60828"/>
        <property type="gene ID" value="ERS852478_03328"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="PTHR43450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="5">
        <location>
            <begin position="143"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="4">
        <location>
            <begin position="198"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="227"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="414"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO60828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="443" mass="51490" checksum="754DCFEA8C1184DD" modified="2016-09-07" version="1">MEFMDGTWKKEINTWEELVGNNLLNQEAVIEGAVHSIRNMGDVAFIILRRREGLFQTVYENEMANVSIHELKEAMTIRVKGILHEEERAPHGRELRIRHIDILSTPAEPLPMAIDKWKLNTSLEAKLNYRPISLRNIQERSKFKIQEALTKAFRDYLYGQGFTEIHTPKIGARGAEGGANLFKFSYFHKPAVLAQSPQFYKQMMVGVFDRVFETGPVFRAEKHNTKRHLNEYTSLDFEMGYIDSFEEIMAMETGFLQYAMNLLKTEYAKEVQILKLEIPDVSKIPAVRFDVAKELVSQKYNRKIRNPFDLEPEEEALIGQYFKEEYGSDFVFVTHYPSKKRPFYAMDDPEDARFTLSFDLLFKGLEITTGGQRIHDYNMLVQKIEDRGMTQEGMEQYLDTFKHGMPPHGGLGIGLERLTMQLIGEENVRETCLFPRDMNRLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GVR4</accession>
    <name>A0A174GVR4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66812">
        <property type="protein sequence ID" value="CUO66812"/>
        <property type="gene ID" value="ERS852478_03516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO66812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="185" mass="22324" checksum="C591FF9EC6BF4643" modified="2016-09-07" version="1">MHRGVRRKPIFEDEMDHQVLLQIIKTSLSKYSCWLHAYCLMTNHVHLLLETGDIEIGKFMKYMSECYAIYYNHKYGYRGHVFESRYKSCLVKEDAYFLQTSRYIHLNPVKAQMADYPEDHLWSSYRTMIGITDDGITEKKKTLAYFPKNSIYQYREFVEDIGHKYIVQEQHIRKMIGEDELWLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H056</accession>
    <name>A0A174H056_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conjugal transfer coupling protein TraG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_03572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VirD4/TraG family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201442.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68412">
        <property type="protein sequence ID" value="CUO68412"/>
        <property type="gene ID" value="ERS852478_03572"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003688">
        <property type="entry name" value="TraG/VirD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02534">
        <property type="entry name" value="T4SS-DNA_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO68412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="612" mass="69910" checksum="2C25F6E2BB03A66A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HF83</accession>
    <name>A0A174HF83_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03745</name>
        <name evidence="3" type="ORF">GT712_18755</name>
        <name evidence="2" type="ORF">GT728_19125</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 5 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A1</strain>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000046">
        <property type="protein sequence ID" value="CUO73582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000080">
        <property type="protein sequence ID" value="MZL35227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000063">
        <property type="protein sequence ID" value="MZS91022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379880.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73582">
        <property type="protein sequence ID" value="CUO73582"/>
        <property type="gene ID" value="ERS852478_03745"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z7P3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO73582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL35227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS91022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="273" mass="32004" checksum="24553FE6103E8908" modified="2016-09-07" version="1">MEIRNFDAYSPLHKSGHTSKGDQLKWKIDDRWYKADYMGYEGLSEVLVSDLLQKSTCPFPFVEYEAAVIEYNGKIFQGCSSLDFLKANQVLIPLEKLYRRYTGESLAVKLSDFADVSERIQYLVTQVEEITKIDNFGAYLTAMLEIDAFFMNEDRHTNNIAVIYNEKTQKYELSPFFDQGLCMFADINQDYPIDQSLEYCLEKIEAKPFSSDFDIQLDAAEELYGIQIGFQFTFKDIQIYLQKNSENYPREVIRRVEQLLRGQMRKYGYLMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HFN1</accession>
    <name>A0A174HFN1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FtsX-like permease family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_03686</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-4 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO71968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201492.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71968">
        <property type="protein sequence ID" value="CUO71968"/>
        <property type="gene ID" value="ERS852478_03686"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027022">
        <property type="entry name" value="ABC_permease_BceB-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018968">
        <property type="entry name" value="ABC_permease_BceB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="85"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO71968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="655" mass="75930" checksum="333503D14C937C7E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HJI9</accession>
    <name>A0A174HJI9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase 1</fullName>
            <ecNumber evidence="1">3.2.2.20</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DNA-3-methyladenine glycosylase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tag</name>
        <name evidence="1" type="ORF">ERS852478_03794</name>
        <name evidence="2" type="ORF">GT712_14650</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.2.20" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000050">
        <property type="protein sequence ID" value="CUO75082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000033">
        <property type="protein sequence ID" value="MZS90276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381293.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75082">
        <property type="protein sequence ID" value="CUO75082"/>
        <property type="gene ID" value="ERS852478_03794"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO75082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS90276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="194" mass="22624" checksum="D9D4E509BDB25CC5" modified="2016-09-07" version="1">MKWADGKIRCCWANPRNERYIRYHDEEWGVPVHDDRKLFEMLILECFQAGLSWECVLNKRDAFRKAFDNFDPEKVSAYTEDKLEALRSNPGIIRNRLKIQAAVTNAWAFLEIQKEYGSFSDYIWHWTDGKVVCETGRTSSELSDRISKDLKKRGMKFVGTTVIYAYLQAVGVLCSHEQGCFLANQKAEHHNSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HKP1</accession>
    <name>A0A174HKP1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03742</name>
        <name evidence="3" type="ORF">GT712_18740</name>
        <name evidence="2" type="ORF">GT728_19110</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 5 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A1</strain>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000046">
        <property type="protein sequence ID" value="CUO73529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000080">
        <property type="protein sequence ID" value="MZL35224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000063">
        <property type="protein sequence ID" value="MZS91019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379878.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73529">
        <property type="protein sequence ID" value="CUO73529"/>
        <property type="gene ID" value="ERS852478_03742"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO73529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL35224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS91019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="299" mass="35429" checksum="092B87FA4FEAFC3C" modified="2016-09-07" version="1">MKEKAYFHLPGLFEFYELYRMFLPLFREHREYFYDWCEIGSIYGAPADCIWGGGRAGFGENDPEEVLELMQEYGISARLTFSNSLLRQEHLSDRKCNALCRLFERNREPQNGVIIYSELLLEYIKEQYPGLYFVSSTTKVLTDFTQLEEEIRRKDFHYVVPDFRLNKAFDKLNTLSQAEKDKVEFLCNECCWFGCRDRKACYETVSRKNLGENCLEHYCKAPERERGYLFSKAIENPGFIGINDIRDIYLPMGFSNFKIEGRGLGSALILEFLLYYMTRPEYQIHVREKIYLDSMLDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HMH8</accession>
    <name>A0A174HMH8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cusR</name>
        <name evidence="10" type="ORF">BWLFYP14_00638</name>
        <name evidence="9" type="ORF">ERS852478_03764</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000047">
        <property type="protein sequence ID" value="CUO74085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000009">
        <property type="protein sequence ID" value="VUX62860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705442.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74085">
        <property type="protein sequence ID" value="CUO74085"/>
        <property type="gene ID" value="ERS852478_03764"/>
    </dbReference>
    <dbReference type="GeneID" id="66494638"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO74085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX62860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="222" mass="25642" checksum="618EC9E4241A494E" modified="2016-09-07" version="1">MHILIIEDEEQLCRSMAEGLRMDGYETDTCFDGEEGLELCMTENYDLILLDLNLPGIDGLEILRQFRTFNTNTPVLILSARVQIQDKVEGLDLGANDYLTKPFHFEELEARIRSLTRRKFIQEDVCLRCSRITFDTRTREASVDGTPLALTRKESALLEYFLLHRNRIISPEEMIEHLWDGSVNSFSNSIRVHISSLRKKLRTALGYDPIQNKIGQGYILEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J575</accession>
    <name>A0A174J575_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">pyrH</name>
        <name evidence="12" type="ORF">BWLFYP14_02378</name>
        <name evidence="8" type="ORF">ERS852478_02066</name>
        <name evidence="9" type="ORF">ERS852523_00022</name>
        <name evidence="11" type="ORF">GT712_14135</name>
        <name evidence="10" type="ORF">GT728_13835</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO94892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000035">
        <property type="protein sequence ID" value="MZL34254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000030">
        <property type="protein sequence ID" value="MZS90177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX66008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707658.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000073_gene2014"/>
    <dbReference type="EnsemblBacteria" id="CUO17845">
        <property type="protein sequence ID" value="CUO17845"/>
        <property type="gene ID" value="ERS852478_02066"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94892">
        <property type="protein sequence ID" value="CUO94892"/>
        <property type="gene ID" value="ERS852523_00022"/>
    </dbReference>
    <dbReference type="GeneID" id="66493740"/>
    <dbReference type="eggNOG" id="COG0528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="128"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO17845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO94892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL34254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS90177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX66008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="231" mass="25036" checksum="A404A05ED4B55CCC" modified="2016-09-07" version="1">MKRVLLKLSGEALAGEKKTGFDEATVIEVAKQIRTIAEEGLEIGIVIGGGNFWRGRTSETIDRNKADQIGMLATVMNCIYVSDICRYLGLKTEIFTPFVCGAFTSLYSKDAVEASFAQGKIVFFAGGTGHPYFSTDTATVLRAVEIEAEAILLAKAVDGIYDSDPKTNPNAVKYDEISIEEVVAKKLAAMDLTASIMCMEQKMPMLVFALDEKDSIINAVHGKFVGTKVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JIM8</accession>
    <name>A0A174JIM8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GGGtGRT protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_00387</name>
        <name evidence="1" type="ORF">ERS852478_01967</name>
        <name evidence="2" type="ORF">ERS852523_00123</name>
        <name evidence="4" type="ORF">GT712_18305</name>
        <name evidence="3" type="ORF">GT728_09095</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO14667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO97468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000059">
        <property type="protein sequence ID" value="MZS90945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707497.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2281"/>
    <dbReference type="EnsemblBacteria" id="CUO14667">
        <property type="protein sequence ID" value="CUO14667"/>
        <property type="gene ID" value="ERS852478_01967"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97468">
        <property type="protein sequence ID" value="CUO97468"/>
        <property type="gene ID" value="ERS852523_00123"/>
    </dbReference>
    <dbReference type="GeneID" id="66495585"/>
    <dbReference type="eggNOG" id="ENOG502Z7JK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025964">
        <property type="entry name" value="GGGtGRT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14057">
        <property type="entry name" value="GGGtGRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO14667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO97468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX62256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="336" mass="35753" checksum="4E09903A1CB4FE9B" modified="2016-09-07" version="1">MALFESYERRIDKINSVLNSYGIASIEEAEKITKDAGLNVYDQIKGIQPICFENACWAYTVGAAIAIKKGCKKAADAAAAIGEGLQAFCIPGSVADTRKVGLGHGNLGKMLLEEETECFCFLAGHESFAAAEGAIGIAEKANKVRQKPLRVILNGLGKDAAQIISRINGFTYVETEYDPYKNEVKEVFRKAYSEGLRAKVNCYGANSVPEGVAIMWKEDVDVSITGNSTNPTRFQHPVAGTYKKERLEAGKKYFSVASGGGTGRTLHPDNMAAGPASYGMTDTLGRMHSDAQFAGSSSVPAHVEMMGLIGAGNNPMVGMTVAVAVSIEEAAKAGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KLV6</accession>
    <name>A0A174KLV6_9FIRM</name>
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        <submittedName>
            <fullName evidence="6">Anaerobic ribonucleoside-triphosphate reductase</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nrdD_2</name>
        <name evidence="7" type="synonym">nrdD</name>
        <name evidence="5" type="synonym">nrdD_1</name>
        <name evidence="9" type="ORF">BWLFYP14_01780</name>
        <name evidence="5" type="ORF">ERS852478_00741</name>
        <name evidence="6" type="ORF">ERS852523_00602</name>
        <name evidence="8" type="ORF">GT712_03050</name>
        <name evidence="7" type="ORF">GT728_03875</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.17.4.2" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP11811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993622.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000016_gene3683"/>
    <dbReference type="EnsemblBacteria" id="CUN66464">
        <property type="protein sequence ID" value="CUN66464"/>
        <property type="gene ID" value="ERS852478_00741"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11811">
        <property type="protein sequence ID" value="CUP11811"/>
        <property type="gene ID" value="ERS852523_00602"/>
    </dbReference>
    <dbReference type="GeneID" id="66493516"/>
    <dbReference type="eggNOG" id="COG1328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02487">
        <property type="entry name" value="NrdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN66464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP11811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL32355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS88089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX64986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="711" mass="81165" checksum="13CBAD4CB57924D8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KTC2</accession>
    <name>A0A174KTC2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FeoA domain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">FeoA domain protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Ferrous iron transport protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BWLFYP14_02562</name>
        <name evidence="3" type="ORF">ERS852478_00061</name>
        <name evidence="4" type="ORF">ERS852523_00706</name>
        <name evidence="6" type="ORF">GT712_07600</name>
        <name evidence="5" type="ORF">GT728_03135</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP15283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000005">
        <property type="protein sequence ID" value="MZL32214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703058.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1425"/>
    <dbReference type="EnsemblBacteria" id="CUN42580">
        <property type="protein sequence ID" value="CUN42580"/>
        <property type="gene ID" value="ERS852478_00061"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15283">
        <property type="protein sequence ID" value="CUP15283"/>
        <property type="gene ID" value="ERS852523_00706"/>
    </dbReference>
    <dbReference type="GeneID" id="66492871"/>
    <dbReference type="eggNOG" id="COG1918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN42580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP15283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL32214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS88935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="69" mass="7396" checksum="B820D28AA32D9AAC" modified="2016-09-07" version="1">MPLSMVNAGEPFTIKRIGGKEEVKRHLEELGFVVGGVVTVVSEINGSLIVNVKESRVAIGKDMASKIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M9K8</accession>
    <name>A0A174M9K8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">secY</name>
        <name evidence="17" type="ORF">BWLFYP14_00275</name>
        <name evidence="13" type="ORF">ERS852478_01677</name>
        <name evidence="14" type="ORF">ERS852523_01275</name>
        <name evidence="16" type="ORF">GT712_08890</name>
        <name evidence="15" type="ORF">GT728_04790</name>
    </gene>
    <organism evidence="14 19">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 18">2789STDY5834863</strain>
            <strain evidence="14 19">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="15 21 22" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 22">BIOML-A1</strain>
            <strain evidence="16 21">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="17 20" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707275.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2964"/>
    <dbReference type="EnsemblBacteria" id="CUO03301">
        <property type="protein sequence ID" value="CUO03301"/>
        <property type="gene ID" value="ERS852478_01677"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33053">
        <property type="protein sequence ID" value="CUP33053"/>
        <property type="gene ID" value="ERS852523_01275"/>
    </dbReference>
    <dbReference type="GeneID" id="66496140"/>
    <dbReference type="eggNOG" id="COG0201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO03301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUP33053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL32536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZS89183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VUX67434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="438" mass="48012" checksum="99C651FC6DA272B1" modified="2016-09-07" version="1">MFETLKNVFRVKEMRRKLLYLIWMIFIIRIGCQIPVPGVDSDFFKQWFSSNAGDAFNFFDAFTGGSFERMSIFALNITPYITSSIIIQLLTIAIPALEEMQRDGEEGRKKMTAITRYVTVGLALFESIAMAIGFGRQGMIPNLDFFKGVVVVACLTAGSAMLMWLGERITEKGVGNGISIVLTINIISRVPSDLTLLYENFIKGKTIAKGTLAGLIIAAVILLVVVLVLILNGAERRIPVQYSKKMVGRKLMGGQSTNIPLKVNTAGVIPVIFASSIMSFPAVIAQLTGKGNGTGIGSEIIRGLSSNNWCNPKQLQYTWGLVLYIVLCVFFAYFYTSITFNPLEVADNIKKQGGFIPGIRPGKPTSDYLTNILNYIIFIGAVGLIIVCVIPFIFNGVFGANVSFGGTSIIIIVGVILETVKQIESQLLVRNYKGFLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NAY1</accession>
    <name>A0A174NAY1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ethanolamine utilization protein EutP</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Propanediol utilization protein PduV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pduV</name>
        <name evidence="5" type="ORF">BWLFYP14_01574</name>
        <name evidence="2" type="ORF">ERS852478_02329</name>
        <name evidence="3" type="ORF">ERS852523_01612</name>
        <name evidence="4" type="ORF">GT712_12720</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EutP/PduV family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO27064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP43718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705593.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000126_gene3815"/>
    <dbReference type="EnsemblBacteria" id="CUO27064">
        <property type="protein sequence ID" value="CUO27064"/>
        <property type="gene ID" value="ERS852478_02329"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP43718">
        <property type="protein sequence ID" value="CUP43718"/>
        <property type="gene ID" value="ERS852523_01612"/>
    </dbReference>
    <dbReference type="GeneID" id="66494445"/>
    <dbReference type="eggNOG" id="COG4917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:cellular biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012381">
        <property type="entry name" value="EutP_PduV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40453">
        <property type="entry name" value="PTHR40453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10662">
        <property type="entry name" value="PduV-EutP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036409">
        <property type="entry name" value="EutP_PduV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR036409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO27064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP43718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="171" mass="19096" checksum="9A36E1FE30A14660" modified="2016-09-07" version="1">MKKIFLMGRSEAGKTSLTQALKGEKLHYVKTQYTNTDDDTIDSPGEYAESKHFSVGLACFSFEADVVAMVQSADEPFSLFGYGSNAFILRPLIGIITKIDSPYANVPMVRQWMLNAGCERIFLVNNVTGEGIDELRAFLNEDVPKLSLEEAKFRQSLGLNEWDPLPEGVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174P523</accession>
    <name>A0A174P523_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9 11">Uracil-DNA glycosylase</fullName>
            <shortName evidence="9">UDG</shortName>
            <ecNumber evidence="4 9 11">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 14" type="primary">ung</name>
        <name evidence="17" type="ORF">BWLFYP14_02237</name>
        <name evidence="13" type="ORF">ERS852478_03207</name>
        <name evidence="14" type="ORF">ERS852523_01946</name>
        <name evidence="16" type="ORF">GT712_14605</name>
        <name evidence="15" type="ORF">GT728_20400</name>
    </gene>
    <organism evidence="14 19">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 18">2789STDY5834863</strain>
            <strain evidence="14 19">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="15 21 22" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 22">BIOML-A1</strain>
            <strain evidence="16 21">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="17 20" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9 11">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 11">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 11">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="4 9 11"/>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000018">
        <property type="protein sequence ID" value="CUP53878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000101">
        <property type="protein sequence ID" value="MZL35463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000032">
        <property type="protein sequence ID" value="MZS90267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703498.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000101.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000004_gene1935"/>
    <dbReference type="EnsemblBacteria" id="CUO56792">
        <property type="protein sequence ID" value="CUO56792"/>
        <property type="gene ID" value="ERS852478_03207"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP53878">
        <property type="protein sequence ID" value="CUP53878"/>
        <property type="gene ID" value="ERS852523_01946"/>
    </dbReference>
    <dbReference type="GeneID" id="66493900"/>
    <dbReference type="eggNOG" id="COG0692">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="PTHR11264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="12">
        <location>
            <begin position="49"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9 10">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO56792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUP53878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL35463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZS90267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VUX65871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="224" mass="25538" checksum="BD8EF18848F917BD" modified="2016-09-07" version="1">MSAISGDWLEALKGEFHQPYYAKLYKTVMTEYQTRKIFPPADDLFNAFHFTPLNEVKVVILGQDPYHNDGQAHGLCFSVKRGVETPPSLVNIYQELHDDCGCYIPNNGYLEKWAKQGVLLLNTVLTVRAHQANSHRGIGWEQFTDAAIQVLNEQDRPIVFLLWGRPAQMKKSMLNNPKHLILEAPHPSPLSAYRGFFGCKHFSKTNEFLVANGLEPIDWQIENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174PSH6</accession>
    <name>A0A174PSH6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">pgi</name>
        <name evidence="9" type="ORF">ERS852478_02781</name>
        <name evidence="10" type="ORF">ERS852523_02211</name>
        <name evidence="11" type="ORF">GT728_15815</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
            <strain evidence="10 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000022">
        <property type="protein sequence ID" value="CUP61618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000046">
        <property type="protein sequence ID" value="MZL34621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705267.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000048_gene1285"/>
    <dbReference type="EnsemblBacteria" id="CUO42841">
        <property type="protein sequence ID" value="CUO42841"/>
        <property type="gene ID" value="ERS852478_02781"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP61618">
        <property type="protein sequence ID" value="CUP61618"/>
        <property type="gene ID" value="ERS852523_02211"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO42841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP61618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL34621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="527" mass="56818" checksum="AD8B740CE118C38F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174PUY1</accession>
    <name>A0A174PUY1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein BlaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">blaI_1</name>
        <name evidence="2" type="ORF">ERS852478_00543</name>
        <name evidence="3" type="ORF">ERS852523_02323</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000023">
        <property type="protein sequence ID" value="CUP64812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025581312.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000062.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000181_gene2870"/>
    <dbReference type="EnsemblBacteria" id="CUN58766">
        <property type="protein sequence ID" value="CUN58766"/>
        <property type="gene ID" value="ERS852478_00543"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP64812">
        <property type="protein sequence ID" value="CUP64812"/>
        <property type="gene ID" value="ERS852523_02323"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN58766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP64812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="130" mass="15281" checksum="E55BE8B032FF9521" modified="2016-09-07" version="1">MQQHYELSDTEYKIMQLFWKNSDPLPFNEILKYCNDELQLNWAVGTAQTYLNRLILKGVLKTNNKRYRKLYSAQLSEEELAQKYARQFVDESFGGSLKNFIASFTQETKLSEADVNELIDILHSNMSEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SP22</accession>
    <name>A0A174SP22_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone protein YajL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yajL</name>
        <name evidence="2" type="ORF">ERS852478_03174</name>
        <name evidence="3" type="ORF">ERS852523_03507</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000053">
        <property type="protein sequence ID" value="CUP98416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580707.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000060.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000094_gene756"/>
    <dbReference type="EnsemblBacteria" id="CUO55482">
        <property type="protein sequence ID" value="CUO55482"/>
        <property type="gene ID" value="ERS852478_03174"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP98416">
        <property type="protein sequence ID" value="CUP98416"/>
        <property type="gene ID" value="ERS852523_03507"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO55482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP98416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="186" mass="19983" checksum="39781F1CDD944DC7" modified="2016-09-07" version="1">MSKKVYIFLADGFEDIEGLTVVDLLRRAGIDIKTVSIKETTRIQTSHGITMLTDAIFAETDFADADMLVLPGGMPGTKYLAGYKPLIDLLTDFNNKGKKIAAICAAPSVFSGLGFLKGRKATSYPSFMEVLSKDGAVTSEDSVVVDGNITTSRGLGTAVDFALSLISQLENEEKAKEIAESVVYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174T270</accession>
    <name>A0A174T270_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02824</name>
        <name evidence="2" type="ORF">ERS852523_03650</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000058">
        <property type="protein sequence ID" value="CUQ02207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43992">
        <property type="protein sequence ID" value="CUO43992"/>
        <property type="gene ID" value="ERS852478_02824"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ02207">
        <property type="protein sequence ID" value="CUQ02207"/>
        <property type="gene ID" value="ERS852523_03650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO43992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUQ02207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="29" mass="2931" checksum="B8538FC0C698F89C" modified="2016-09-07" version="1">MSGISFLCEVAESSAGGKMSVLIAAVMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174T5Z3</accession>
    <name>A0A174T5Z3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Six-cysteine peptide SCIFF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">scfA</name>
        <name evidence="5" type="ORF">BWLFYP14_00519</name>
        <name evidence="1" type="ORF">ERS852478_02524</name>
        <name evidence="2" type="ORF">ERS852523_03679</name>
        <name evidence="4" type="ORF">GT712_02235</name>
        <name evidence="3" type="ORF">GT728_13350</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000060">
        <property type="protein sequence ID" value="CUQ03115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000033">
        <property type="protein sequence ID" value="MZL34162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000004">
        <property type="protein sequence ID" value="VUX62649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703734.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000029_gene645"/>
    <dbReference type="EnsemblBacteria" id="CUO33881">
        <property type="protein sequence ID" value="CUO33881"/>
        <property type="gene ID" value="ERS852478_02524"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ03115">
        <property type="protein sequence ID" value="CUQ03115"/>
        <property type="gene ID" value="ERS852523_03679"/>
    </dbReference>
    <dbReference type="GeneID" id="66495275"/>
    <dbReference type="eggNOG" id="ENOG5033AHS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023975">
        <property type="entry name" value="Six-Cys_pep_SCIFF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13165">
        <property type="entry name" value="SCIFF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03973">
        <property type="entry name" value="six_Cys_in_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO33881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUQ03115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS87940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX62649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="46" mass="4951" checksum="AE8809641A36C5EC" modified="2016-09-07" version="1">MEHIKTLNTKNLQNTVKKGGCGECQTSCQSACKTSCTVGNQSCEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WS30</accession>
    <name>A0A173WS30_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucan-binding repeat</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Transglutaminase-like superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02556</name>
        <name evidence="3" type="ORF">ERS852478_00055</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199480.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN42389">
        <property type="protein sequence ID" value="CUN42389"/>
        <property type="gene ID" value="ERS852478_00055"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033RMR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033732573" evidence="1">
        <location>
            <begin position="27"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="188"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN42389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="326" mass="37267" checksum="670AEA0CDCECB082" modified="2016-09-07" version="1">MKTLKKLLFIIMAVAVLAMPVFGVQAAESDIPVTEQPGVSPTPSPVPIRELVTKGNKIYYYYKGKMVKNKWKRYNGYKYYFGANGNAVRGGQRINNVVYVFDEKGRLFENKQNKIVKSGSNIYHIRTEHGRASIGYFIYKNNLYYADPKGRLYQKKSRQNGQLYFTNSGAARKDYNALLKMRVMQIVSSITNSGMSQSQKLYACWKYVVYGGFYYGGPDPNIYQSGWARSEALRMFRTGYGNCYGFSCIFAALAREIGYTPYMICGRVPGSRDGAADGFTRHCWVEINGLYYDPEAQYAGWMTGVYGYDYYPISHQIQRVVNFCKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WTI2</accession>
    <name>A0A173WTI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vitamin B12 import system permease protein BtuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">btuC_1</name>
        <name evidence="8" type="ORF">ERS852478_00024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199517.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41378">
        <property type="protein sequence ID" value="CUN41378"/>
        <property type="gene ID" value="ERS852478_00024"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN41378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="339" mass="36834" checksum="9524A90AD445D81A" modified="2016-09-07" version="1">MDDKKRTARYWMAFLILAVFLMILFVWNVNAGSIHLSVSEILNIIFRHQGDATAYNIIWEIRLPRILSVIILGGALSVSGFLLQTFFNNPIAGPFVLGISSGAKLVVALLMIYFLSRSISMGSVAMIIAAFIGSMISMGFVLLVAKKVHNMSMLVISGVMIGYICSAVTDFVVTFADDSNIVNLHNWSLGSFSGMSWGNVKVMAIVVLLTMVIVFFMSKPIGAYQLGEVYAQNMGVNIKLFRIGLILLSSILSACVTAFAGPISFVGIAVPHIVKSLLKTARPLLVIPACFLGGAVFCLFCDLIARTVFAPTELSISSVTAVFGAPVVIYIMIRRQKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X6Y2</accession>
    <name>A0A173X6Y2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxybenzoyl-CoA reductase subunit gamma</fullName>
            <ecNumber evidence="3">1.3.7.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hcrC</name>
        <name evidence="3" type="ORF">ERS852478_00238</name>
        <name evidence="4" type="ORF">ERS852523_00417</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
            <strain evidence="4 6">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.7.9" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN47393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000003">
        <property type="protein sequence ID" value="CUP05747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026648500.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000017_gene258"/>
    <dbReference type="EnsemblBacteria" id="CUN47393">
        <property type="protein sequence ID" value="CUN47393"/>
        <property type="gene ID" value="ERS852478_00238"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP05747">
        <property type="protein sequence ID" value="CUP05747"/>
        <property type="gene ID" value="ERS852523_00417"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN47393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP05747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="155" mass="17288" checksum="CBE5F4B096981387" modified="2016-09-07" version="1">MNINFWLNGVNRHAEISPDTLLIDFLREQGCFSVKRGCETANCGLCTVLMDGRPVLSCSTLAARIEGKKIVTLEGMQREAQEFGSFLANEGAEQCGFCNPGFIMNVFAMLNEIKDPTEEQIKEYLAGNLCRCSGFVSQTRSILKFLKYKKAQEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XBX4</accession>
    <name>A0A173XBX4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Addiction module antitoxin, RelB/DinJ family</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Type II toxin-antitoxin system RelB/DinJ family antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00265</name>
        <name evidence="3" type="ORF">GT712_15860</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000040">
        <property type="protein sequence ID" value="MZS90501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199534.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49289">
        <property type="protein sequence ID" value="CUN49289"/>
        <property type="gene ID" value="ERS852478_00265"/>
    </dbReference>
    <dbReference type="GeneID" id="66493199"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015643">
        <property type="term" value="F:toxic substance binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044010">
        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026262">
        <property type="entry name" value="DinJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38781">
        <property type="entry name" value="PTHR38781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003108">
        <property type="entry name" value="DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN49289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="90" mass="10040" checksum="5816A713B123C1CE" modified="2016-09-07" version="1">MATTNLNIRIDKAIKDQAEEIFNELGLNMTTAVNMFLRTAIREHGIPFELKLEVPNDTTATAIEEGRKMMKDPSAPRYSSMDALKAALDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XHB9</accession>
    <name>A0A173XHB9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199569.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51211">
        <property type="protein sequence ID" value="CUN51211"/>
        <property type="gene ID" value="ERS852478_00329"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN51211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="216" mass="24201" checksum="40251954F1618935" modified="2016-09-07" version="1">MKHLVITIGCEYGAKGNAIGKKIAQDLGIKFYDRDLVDEIIKEVGIPTDIMDRVEEGGTIAGKGAQGDVRGSFSKYADLTDRAIHVQKQIIRKLAQKEACVIIGRSADYILKDTEGIQLVRAFIYAPNDVRVHNIMESHNLSEKDAKLLLDEKDKRYHKRHLALTGSNRGDRHNRDILINSDFLGIQGTAEYLEDLIAKKIRKKGGLTYGTENIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XHG0</accession>
    <name>A0A173XHG0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">malQ_1</name>
        <name evidence="8" type="ORF">ERS852478_00283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199545.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIOY010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49828">
        <property type="protein sequence ID" value="CUN49828"/>
        <property type="gene ID" value="ERS852478_00283"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN49828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="501" mass="58862" checksum="A56CD27804387AD0" modified="2016-09-07" version="1">MGKRAAGILMPISSLPSDYGIGCFSKSAYEFVDWLKEAGQTYWQILPLGPTSYGDSPYQSFSTFAGNPYFIDLDTLVEEGVLDKKDCEKVNWGKKPEEVDYEKIYKGRYPLLRKAYENSDISKNPDYQKFVAENSWWLSDYALFMAVKDRFEGVEWTKWAEDIRLRWNNAMDYYREELYFDIEFQQYMQFKFYEQWMKLKSYANSKGIQIIGDIPIYVAMDSADAWAHPELFQLDQDNVPLAVAGCPPDGFSATGQLWGNPLYRWDYHRNTGYQWWISRMSYCFRLYDVVRIDHFRGFDEYFSIPYGDKDAKGGHWEKGPGIDLFRKIEQALGWKQVIAEDLGYMTDSVRHLVYESGFPGMKVLEFAFDSRDSGCASDYLPHNYPENCVAYTGTHDNETIVGWWKSITATERKLARDYLCDHATPEEELYKCFISLIMRSVARVCVIPMQDYMGLDNRFRMNKPSTVGMNWKWRIKKRDLTKKLQKEIHDVTLRYGRKNWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XII9</accession>
    <name>A0A173XII9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mgtE</name>
        <name evidence="9" type="ORF">ERS852478_00337</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199573.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51454">
        <property type="protein sequence ID" value="CUN51454"/>
        <property type="gene ID" value="ERS852478_00337"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="139"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="203"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN51454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="464" mass="51732" checksum="9D45B3A5D8FE691E" modified="2016-09-07" version="1">MEKRVQDYSKEILKIIRSNTSPAVMGGRLQDYHENDLADVMPKLTVQERCKLYRILDTDMLSDIFEYTDEENAAEYLNEMDVRKAAAILSRMETDALADVLNKVEKTKKKILIDLLEPEVRRDVEMIASFDEDEIGSRMTTNYIVITDKLTVKQAMSSLIEQAAKNDNISTIFVVTEQQKFYGAINLKELIIARRDDLLENLVVTSYPYVYAEENIDACIEELKDYSEDSIPVLDNDNQLLGVITSASIIDLVDDEMGDDYAKLAGLTAEEDLKEPLKESMKKRLPWLIILLGLGMVVSSVVGIFEKVVTALPIIMCFQSLILDMAGNVGTQSLAVTIRVLMDESLTGKQKLELVWKEMRIGLCNGGLLGILSFALIGLYIYLFKGKTLLFSYAVSGCIGVALLLAMLISSAVGTCIPLFFKKINIDPAVASGPLITTVNDLVAVITYYGLSWLFLLKMLNFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XJ67</accession>
    <name>A0A173XJ67_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ilvB_1</name>
        <name evidence="13" type="synonym">ilvB</name>
        <name evidence="12" type="ORF">ERS852478_00323</name>
        <name evidence="13" type="ORF">GT728_20370</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000100">
        <property type="protein sequence ID" value="MZL35458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059855.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000100.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51076">
        <property type="protein sequence ID" value="CUN51076"/>
        <property type="gene ID" value="ERS852478_00323"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="6"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="194"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="383"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN51076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL35458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="572" mass="63252" checksum="ED25236E27071948" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XLA4</accession>
    <name>A0A173XLA4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacteriophytochrome cph2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cph2_2</name>
        <name evidence="2" type="ORF">ERS852478_00367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199587.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52454">
        <property type="protein sequence ID" value="CUN52454"/>
        <property type="gene ID" value="ERS852478_00367"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN52454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="270" mass="30471" checksum="8DA5FDB73B5D5BA3" modified="2016-09-07" version="1">MKVNKANEFYKILERKAIYPVFQPIVNLQTGRVSGYEALSRIDRSSTTLTISDLFVIAEQVGCVWKLEKLCRNKALKAAVEKPENVKLFLNVDGNIIQDKAFIQGFTNRRAMKAGVPASDIVFEITERSDIENYQILQQIMKHYADQGYEIALDDVGAGHLGLNRVVNTTPDYLKADIELVRDIHKYKKKEIMMKLLLDYCNATGAILIAEGIETVQELECLHSLGVHYGQGFFLGKPERAFGNISAESEEILERLNGRKNILFLDISGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XM57</accession>
    <name>A0A173XM57_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjP</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">L-arabinose transport system permease protein AraQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_3</name>
        <name evidence="11" type="synonym">araQ_8</name>
        <name evidence="8" type="synonym">ycjP_11</name>
        <name evidence="11" type="ORF">BWLFYP14_01998</name>
        <name evidence="7" type="ORF">ERS852478_00379</name>
        <name evidence="8" type="ORF">ERS852523_01568</name>
        <name evidence="10" type="ORF">GT712_06065</name>
        <name evidence="9" type="ORF">GT728_06435</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000013">
        <property type="protein sequence ID" value="CUP42156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000011">
        <property type="protein sequence ID" value="MZL32848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000009">
        <property type="protein sequence ID" value="MZS88663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380668.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000060_gene471"/>
    <dbReference type="EnsemblBacteria" id="CUN52794">
        <property type="protein sequence ID" value="CUN52794"/>
        <property type="gene ID" value="ERS852478_00379"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP42156">
        <property type="protein sequence ID" value="CUP42156"/>
        <property type="gene ID" value="ERS852523_01568"/>
    </dbReference>
    <dbReference type="GeneID" id="66496009"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="78"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN52794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP42156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL32848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS88663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX65407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="297" mass="33769" checksum="66CA254EFBF39DFA" modified="2016-09-07" version="1">MEKKKRKYSRTDRLILGIGFTILGLFVLSIAIPIIYVVLASFMDPTVLNNQGLSSDIKDWTLDAYRRVLENEMIWRGFLNSFLYSFVFTVISVFVTLLAAFPLSKKEFVGRKFFNLIFLITMFFGGGMIPTFILINQLHMVNTVWAVLIPGAFNVWNMILARTYYQSIPAELREASAIDGANEIQHFFKIMMPVCKPIIAVLALWSFVGMWNSYFDAMIYLNDANLQPLQLVLRSILVQNTPQPGMIADIQSTAEMAKVAEQLKYATIVVSSLPLLVMYPFFQKYFDKGIMVGSVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XT64</accession>
    <name>A0A173XT64_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199604.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53745">
        <property type="protein sequence ID" value="CUN53745"/>
        <property type="gene ID" value="ERS852478_00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015664" evidence="1">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="153" mass="17124" checksum="ACFC62ACC1FEB884" modified="2016-09-07" version="1">MKKIMLSLLTISLIGTTVMPVYAADVYGEETTNLYSYNEGAMYDDDHVKEYSADVEDEKLQKDFEAAINDGIGLSTDDFSETSYSANVDETMQSENEIESLEADFEAAMQDENIKLSEDGIETMNLISTADYNIDTEYAVEVNDYKSKPILDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y0H7</accession>
    <name>A0A173Y0H7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199679.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57424">
        <property type="protein sequence ID" value="CUN57424"/>
        <property type="gene ID" value="ERS852478_00499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN57424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="377" mass="43910" checksum="636B4D2E31FA9571" modified="2016-09-07" version="1">MKIYYREKSGGIEILRCFGMGDRVEIPGMIEDKLVVSAASYAFSSHMNEKEELKNAGLWEVSDGLGFGREEHVLAGNDVEEIVFPDTLKEIGRYIFYGCGNLRKLEFSDSLMQIGCGAFTGCHALEKLTVHMRQGKKSGVKEMLGEMWQRIDVNFLYEYEEDGIEKSDIMHRRENKSEARLVFPEHYDEAVENTPARILYTEYHGSGSNYRQCFYDRELNYQEYDRLFEMAVAMDKLEVLVDMSFGRLEFPYGLTGNARENYREYIRKNLEDIAEYLVKQEDMHRLEMISSQKLWTLEGIDSALDCASKRKETEVSAFLMNERANLVDNQAGSERIDVDNLQNNQKADRTEQGKNEQWQNTEKPLNVRNIRRKRFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y4D2</accession>
    <name>A0A173Y4D2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor RpoD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199695.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58513">
        <property type="protein sequence ID" value="CUN58513"/>
        <property type="gene ID" value="ERS852478_00535"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN58513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="254" mass="28960" checksum="133B77FE2B0DF207" modified="2016-09-07" version="1">MDIQKFQQKLTEVCELGEKNGKVLKPEQIKECFGELDLDKSQLIKILQYLKLKGISIEGAEEISAASQTGPEEVSEEKEEKVPLTAEEEAYLKEYLEGLEEQEQGERSAEELFELISKGDALAQAELSQKYLHAAAEMAVEMNCEEIFIADLIQEANISLLMALGEEEPEKKDEKWLLGRIRCGIRHAIEEQTQRKFEDDYLVAKVEKLEAAVRELTEDEEDESSKFSVEELAIILDMDEEEIRDVLRLTGDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YG24</accession>
    <name>A0A173YG24_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Internalin-J</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">inlJ_1</name>
        <name evidence="3" type="ORF">ERS852478_00638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199731.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61955">
        <property type="protein sequence ID" value="CUN61955"/>
        <property type="gene ID" value="ERS852478_00638"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016152" evidence="2">
        <location>
            <begin position="29"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN61955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="501" mass="53597" checksum="3ADF9852096A8913" modified="2016-09-07" version="1">MKNRKLNQLLVAGMISAAMMTSGISVQAADFSDDTSTVEEQSVDAAEEEAPEVEDGSEFQSDAAEASSAVAVSSANFPDAKFRQYILDNIDTDKDKMLSAAEIKAAKTIDVSGLGISNLKGIESFTYATDLFAANNKLTSVNITKNTKVAYLNLSNNSLAGTLDLSKCTNLRVVKYGSNKLTKVVMPSKKYLKNLDFVDASSNKFTTQANAGLNIGDTDYVKSLSEVNASNNAITSFNCAGFQGILDLRNNKITSLKLENSKEGSQVVSLYLDGNSLSKTSSIDFTPEWIAVPQQFSCDAGVSSKVKMLKATASITSATWDQIVVNVGSSTDDASYKLEKKTGNGTYETVKTWDNGDLADAEFGEDYTDNVISTGTAYTYRVTATVQVKDANKNLRSWSNSAEVKATATGTKPAISVKSTKKGVATVSWKAVAGADGYDVYCGSSKKSQKGTVVKGTTKLTANKTKLTSGKTYYFRARAYKMVGSSKVYTGYSTVKSVKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YMX7</accession>
    <name>A0A173YMX7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multiple sugar-binding periplasmic protein sbpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sbpA_1</name>
        <name evidence="3" type="ORF">ERS852478_00681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019162753.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64415">
        <property type="protein sequence ID" value="CUN64415"/>
        <property type="gene ID" value="ERS852478_00681"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016281" evidence="1">
        <location>
            <begin position="29"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="34"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN64415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="355" mass="38427" checksum="EDBFD98BC7BBF38A" modified="2016-09-07" version="1">MKKKLVSAILCASMVAGMVVIPGVAVKADDKKLIGVTMPTKDLQRWNQDGENMKKELEAAGYEVDLQYASNDVSTQVSQLENQVANGCDLLVVASIDGSSLGEPLKQAKEAGIPVISYDRLLMNSDAVSYYATFDNYKVGQKQGEYLVDALDLDNQDGPFNIELFTGDPGDNNCNFFFGGAMDVLQKYIDEGKLVVKSGQTEFEQVATANWDSAKAQDRMDTIIAGNYSDGTNLDAVLCSNDSTALGVENALAASYTGEYPIITGQDCDTPNVKNLVAGKQAMSVFKDTRALASAVVKMVDSIMKGEEPEVNDTESYDNGTGIIPTYLCDPVVVTVDNYKEMLIDSGYYTEDQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YNJ1</accession>
    <name>A0A173YNJ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">braC</name>
        <name evidence="5" type="ORF">ERS852478_00696</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199765.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64907">
        <property type="protein sequence ID" value="CUN64907"/>
        <property type="gene ID" value="ERS852478_00696"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016295" evidence="3">
        <location>
            <begin position="29"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="33"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN64907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="384" mass="40751" checksum="4856D2CB78E13DB8" modified="2016-09-07" version="1">MKNLKKIISVTAAAAMVMTTVAPVSVFADDATFKIGGIGPVTGAAAIYGQAVKNATELAINEVNEDGGINGYQVEFKFEDDENDAEKTLNAYNALKDWGMNILVGTVTSTPCVAVANETAADNMFQLTPSGSATECVANPNVFRVCFSDPNQGTAAAQYIGEHKLATKVAIIYDSSDVYSSGITQNFTAEAANQGIEIVSSEAFTADNNKDFSVQLQKAKDGGAELVFLPIYYTEASLILAQADSMGFETKFFGCDGMDGILGVENFDTSLAEGLMLLTPFAADSTDEKTQNFVKAYKDAYKDTPNQFAADAYDAVYAVKAAAEKEDVKADMDVADICAALEKGMTEITLEGVTGDEITWTEDGEPNKAPKAVEIKDGAYAAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z2Z6</accession>
    <name>A0A173Z2Z6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_00624</name>
        <name evidence="1" type="ORF">ERS852478_00837</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000006">
        <property type="protein sequence ID" value="VUX62846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69806">
        <property type="protein sequence ID" value="CUN69806"/>
        <property type="gene ID" value="ERS852478_00837"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN69806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX62846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="82" mass="9590" checksum="2CF645093A2D718C" modified="2016-09-07" version="1">MTPKISLSFNLRGFRIQAYENDIQILKLCVKYGVEIMLGSDAHREEDVGDFTRTEKILKEVDFPEELIVNRSLSYVKNRLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z4X6</accession>
    <name>A0A173Z4X6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="10">ATP-PFK</shortName>
            <shortName evidence="10">Phosphofructokinase</shortName>
            <ecNumber evidence="10">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pfkA_1</name>
        <name evidence="10" type="synonym">pfkA</name>
        <name evidence="12" type="ORF">ERS852478_00853</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199825.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71334">
        <property type="protein sequence ID" value="CUN71334"/>
        <property type="gene ID" value="ERS852478_00853"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="4"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="179"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="284"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="112"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity; cannot use PPi as phosphoryl donor" evidence="10">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN71334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="360" mass="38991" checksum="248EAFE33CC5D7B4" modified="2016-09-07" version="1">MIKRIGMLTSGGDCQALNATMRGVVKGLSNNLDELEVYGFDDGYKGLIYGKYRMLTSKDFSGILTQGGTILGTSRQPFKLMRVPDENGLDKVEAMKQTYYKLCLDCLVILGGNGTQKTANLLREEGLNIIHLPKTIDNDIYGTDMTFGFQSAVNIATNAIDCIHTTASSHGRVFIVEIMGHKVGSLTLHAGVAGGADIILIPEIPYDIKKVTAAIQKRAKAGKRFTILAVAEGAISKEDAELPKKKYKERLEARAKKYPSVSYEIADQIYKEIGSEVRVTVPGHTQRGGEPCPYDRVLSTRIGAGAAQAIMDGEYGIMIGVVNGKIKRVPLEECAGKLKMVSPKDQLVVAAKQIGISFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z6A7</accession>
    <name>A0A173Z6A7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein BWLFYP14_01236</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BWLFYP14_01236</name>
        <name evidence="3" type="ORF">ERS852478_00851</name>
        <name evidence="4" type="ORF">ERS852523_02494</name>
        <name evidence="6" type="ORF">GT712_07955</name>
        <name evidence="5" type="ORF">GT728_01000</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000026">
        <property type="protein sequence ID" value="CUP69515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS89004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706923.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000122_gene2850"/>
    <dbReference type="EnsemblBacteria" id="CUN71260">
        <property type="protein sequence ID" value="CUN71260"/>
        <property type="gene ID" value="ERS852478_00851"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP69515">
        <property type="protein sequence ID" value="CUP69515"/>
        <property type="gene ID" value="ERS852523_02494"/>
    </dbReference>
    <dbReference type="GeneID" id="66492979"/>
    <dbReference type="eggNOG" id="COG0718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN71260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP69515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL31810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS89004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX64107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="118" mass="12627" checksum="F99B530CF3E87DBC" modified="2016-09-07" version="1">MAKRGGFPGMGMPGNMNNLMKQAQKMQRQMEENQKALEEKEFTATAGGGAVEVTISGKREVTKVKLQEEVVDPDDIEMLEDLIVAATNEALRKVEEESTAVMSKLTGGLGGLGGGLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZBD0</accession>
    <name>A0A173ZBD0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-xylosidase</fullName>
            <ecNumber evidence="2">3.2.1.177</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yicI_2</name>
        <name evidence="2" type="ORF">ERS852478_00898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.177" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72485">
        <property type="protein sequence ID" value="CUN72485"/>
        <property type="gene ID" value="ERS852478_00898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061634">
        <property type="term" value="F:alpha-D-xyloside xylohydrolase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN72485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="163" mass="18069" checksum="EE6DD99BE37F210A" modified="2016-09-07" version="1">MLGDSILVAPIFNKEGHAEYYLPAGKWTHLLSGEVKEGGRWYEEDYDFSSLPVFVRENTLLPIGAVDTTVDYELEKDVQIQVYEVNETASCEVVTRKGETAFTVKAVREGNKLTLEASAENGGMTYLLRNIHEIADVTGGSIVKDTENGIIIVPEGCRQEIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZC48</accession>
    <name>A0A173ZC48_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_03347</name>
        <name evidence="2" type="ORF">ERS852478_00905</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002569239.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72725">
        <property type="protein sequence ID" value="CUN72725"/>
        <property type="gene ID" value="ERS852478_00905"/>
    </dbReference>
    <dbReference type="GeneID" id="61912445"/>
    <dbReference type="GeneID" id="66495688"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033731968" evidence="1">
        <location>
            <begin position="27"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN72725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX67070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="162" mass="18475" checksum="862977D9AD15D720" modified="2016-09-07" version="1">MQKKQLSVLVLIILCFLLGCNRETPKDESQQNYEDESNISKTNGEELVNINSELLGSTPFDIQIDKTALQTRKETETEVTIKTNLTDWGYTVSSEKGKISDINKNSFIYIAPKDERDDTIKIQLSDYENGISYEYTIPLIFAGNNEHSLDKFKENLSRLPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZE38</accession>
    <name>A0A173ZE38_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensory histidine kinase DcuS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053339.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73949">
        <property type="protein sequence ID" value="CUN73949"/>
        <property type="gene ID" value="ERS852478_00945"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="2">
        <location>
            <begin position="172"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN73949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="276" mass="32220" checksum="32AED26C79CA910B" modified="2016-09-07" version="1">MRKNIKLIPLFLFLFVFQLLYFLSTIYTEKIDHMFLILAVFMVLICILLYCVLSDVLKKSNTEMELAFLQKQKQLKQEQDYSLQIRRQDTRDFQIKTVQGLQDFQSLLEQEKYEQADTAIRNLNQTFQKERFHPYCQNNLLQAILEGKRLRAEQKHIQVSYEILLPEKISINTTDLSSIFFNLLDNAIEACSASGNPDPEIRLSANISNGFLTVYMHNTKNPMQTFTHKTTKSEPGAHGYGLSIIEDICQKYNGSYQWIDHNNTFDSIVLLQIKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZEG1</accession>
    <name>A0A173ZEG1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-ribazole phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199852.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74467">
        <property type="protein sequence ID" value="CUN74467"/>
        <property type="gene ID" value="ERS852478_00963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN74467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="242" mass="28470" checksum="74154528D767C509" modified="2016-09-07" version="1">MKLVIVRHGDPDYSIDSLTEKGWKEVEYLSERLAKLDVKEFYVSPLGRARDTASLTLKKMNRTATECDWLQEFNVLIDRPDITDRKKILWDWLPQDWTQDERFYQYDHWFENERLQKSDAKGYYDYVTGKFDQLLAEHGYVREGHYYRVTKANDDTLVFFCHFGLECVLLSHLMSVSPMVLWHGLCAAPSSVTTVNTEERREGIASFRVSAFGDISHLYVHDEPPAFAARFCEMYSNEDERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZH03</accession>
    <name>A0A173ZH03_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative N-acetylmannosamine-6-phosphate 2-epimerase</fullName>
            <ecNumber evidence="6">5.1.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ManNAc-6-P epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">nanE</name>
        <name evidence="7" type="ORF">ERS852478_00981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23932"/>
            <dbReference type="ChEBI" id="CHEBI:57599"/>
            <dbReference type="ChEBI" id="CHEBI:57666"/>
            <dbReference type="EC" id="5.1.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the NanE family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.9" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199868.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75053">
        <property type="protein sequence ID" value="CUN75053"/>
        <property type="gene ID" value="ERS852478_00981"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00682"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047465">
        <property type="term" value="F:N-acylglucosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009385">
        <property type="term" value="F:N-acylmannosamine-6-phosphate 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04729">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01235">
        <property type="entry name" value="ManNAc6P_epimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007260">
        <property type="entry name" value="NanE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36204">
        <property type="entry name" value="PTHR36204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04131">
        <property type="entry name" value="NanE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN75053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="233" mass="25591" checksum="717748396532E063" modified="2016-09-07" version="1">MTKKELLDAIHGQMIISCQAVKGEPLYVEEKSIMYLMARAAKQAGTPAIRTSSIRDVIAIKEETGLPVIGLVKIQYPGYEGYITPTMKEVDDLVAAGSDVVALDCTLRKRGDGTTVNEFIAQIKEKYPDIILMADISNYEEGVNAWKCGVDIVGTTMSGYTDYTSKKDEPDYELMERLAKDIDIPVIGEGKIHYPDQAVKALQTGAWAIVVGGAITRPLEIAQRFQNAIKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZH19</accession>
    <name>A0A173ZH19_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">sn-glycerol-3-phosphate transport system permease protein ugpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ugpA_3</name>
        <name evidence="7" type="ORF">ERS852478_00999</name>
        <name evidence="8" type="ORF">GT728_13480</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000034">
        <property type="protein sequence ID" value="MZL34188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577890.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75692">
        <property type="protein sequence ID" value="CUN75692"/>
        <property type="gene ID" value="ERS852478_00999"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN75692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL34188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="298" mass="33837" checksum="ECF47EC405A882CC" modified="2016-09-07" version="1">MKNRNKYHAQSQKQAYLFLAPSMLILTVFVFIPLIGALVISVMNIDIYMNNISFAGFGNYLKMFHDSRIGNATFNSFYFALAEVPLQVFMALLMLMLMIKNNRFHKFLRTVFYLPYVCSMTAISIMWSMLLNTNYGMLPYLFKQIGVDFPNVLTSTTWAMPVVILITVWKNFGYTLTLLSAAALGVSNSLYEAAEMDGATGFQKFIYVTIPGIKQTINFCIVTTLITALQVFDQVYVMTKGGPLYKTETLVSYIYNQGFQVAPYDLGYASSIAVYLFLMVAIITFVLRRFVLNRGTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZJE8</accession>
    <name>A0A173ZJE8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199874.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIOV010000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75358">
        <property type="protein sequence ID" value="CUN75358"/>
        <property type="gene ID" value="ERS852478_00989"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN75358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="307" mass="34005" checksum="AA2A1F7BE3A90B41" modified="2016-09-07" version="1">MKSCSVSDGLAIFKALGSPVRVQILRLIQEKEGLNIKQIAQSLKLPVTTLSPHLNLLAEAGLIEFRDEALTHGTQKCCYFAKDWDQLLINMALSGPALQIYSAEIGVGHFSDFSVTPTCGLATSTSFVGQLDQPRYFIHPGSRQARIVWFTTGYLEYILPNFIPDHSVIEELTVSFEISSEAPKFCDIWPSDITFSLNGVILGTWTSPGDYGDRRGKYNPSWWFPFLNQYGLLKKLTITPEGTFLDAEKLSDVSTGQLALTDQSVMKLRFSVLPGAEHPGGCTLFGAGFGDYNQHIRITIGYRPENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZKK9</accession>
    <name>A0A173ZKK9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_01388</name>
        <name evidence="2" type="ORF">ERS852478_01013</name>
        <name evidence="3" type="ORF">GT728_13545</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
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                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Venkatesh S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199925.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80673">
        <property type="protein sequence ID" value="CUN80673"/>
        <property type="gene ID" value="ERS852478_01114"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030436">
        <property type="term" value="P:asexual sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SpoIIGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03419">
        <property type="entry name" value="Peptidase_U4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN80673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="285" mass="31560" checksum="580A89453286C296" modified="2016-09-07" version="1">MHYEIYIDVVFFTNLLIDYILIRFTGILFRCGRSRKRALLGAAAGAVFSCWIIYLRSFLKSGIFLPALVLLHGGCAAGMLVIGCNLKRGSLLLKAILTLYFAAFLCGGFWEVIVSDKLTVKMFLILAAATWSGITALSYLMDSLRIRTKNIYPITIYYKGCGYPFQGFYDSGNLLMDSVNGKPVSVGTEKVLSEICSEETVSCLKHLKENPGESGKPGTAGLHPHFTFFHSIGKEQGMMLAVTFERLCIQTPAEVVCIDNPVFAFSFETSAFGKEYEVLLNSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A077</accession>
    <name>A0A174A077_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trkA</name>
        <name evidence="7" type="ORF">ERS852478_01118</name>
        <name evidence="8" type="ORF">GT712_10575</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
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            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Blautia</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000019">
        <property type="protein sequence ID" value="MZS89502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026649088.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80808">
        <property type="protein sequence ID" value="CUN80808"/>
        <property type="gene ID" value="ERS852478_01118"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
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        <location>
            <begin position="140"/>
            <end position="224"/>
        </location>
    </feature>
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        <location>
            <begin position="230"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="371"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN80808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS89502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="452" mass="49450" checksum="083BE89B9FD90C68" modified="2016-09-07" version="1">MQIIIVGCGKVGRTLAEQLQEEESDITLIDVSSNVITSLQDDIDAMGIVGNGASINTLVEAGIENADILIAVTGSDEMNLLCCLIAQKTGHCQTIARVRNPIYAKEISFIKKRLGVTMIINPELAAAQEISRLLRFPSAIKIDTFARGRVEMLKFKVLPEFNLDGMTISRITEALKCDVLFCAVESRDHVSIPGGNQVIHDGDMVSILASPVNAAAFFKKIGLKTNQVKNAIIVGGGTISYYLTKALLDMNISVKIIEQNESRCETLSDLLPEATIINGDGTNRSLLMEEGLSRTEAFVSLTNMDEENVFLSLFAKTVSNAKLVAKVNRLAFDDVIDNLDIGSVIYPKYITADYILQYVRAMQNSIGSNIETLYHILDNQAEALEFAIRENSPVTGIPLSELNLKKNLLVGYLNRNGQVKIPRGQDTIQVGDTVIIVTSQKGLRDITDILEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A0Y8</accession>
    <name>A0A174A0Y8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_03108</name>
        <name evidence="1" type="ORF">ERS852478_01126</name>
        <name evidence="2" type="ORF">ERS852523_00447</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
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        </lineage>
    </organism>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP06948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704144.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000010.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CUN81078">
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        <property type="gene ID" value="ERS852478_01126"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06948">
        <property type="protein sequence ID" value="CUP06948"/>
        <property type="gene ID" value="ERS852523_00447"/>
    </dbReference>
    <dbReference type="GeneID" id="66493962"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025354">
        <property type="entry name" value="DUF4258"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14076">
        <property type="entry name" value="DUF4258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN81078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP06948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="106" mass="12448" checksum="4C54E17D0F301F44" modified="2016-09-07" version="1">MALDILELRKLCIPKNIRITLHAAKRLEQRRIFLKDVIACIMNGEIIEQYPDDYPYPSCLILGMSIEDKYLHVVIGNHESDLFLITAYFPSFDKWESDFKTRKENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A1F6</accession>
    <name>A0A174A1F6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage III sporulation protein AF</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Stage III sporulation protein AF (Spore_III_AF)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_03077</name>
        <name evidence="3" type="ORF">ERS852478_01157</name>
        <name evidence="4" type="ORF">ERS852523_00478</name>
        <name evidence="5" type="ORF">GT728_00665</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
            <strain evidence="4 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP07751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704104.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2145"/>
    <dbReference type="EnsemblBacteria" id="CUN82137">
        <property type="protein sequence ID" value="CUN82137"/>
        <property type="gene ID" value="ERS852478_01157"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07751">
        <property type="protein sequence ID" value="CUP07751"/>
        <property type="gene ID" value="ERS852523_00478"/>
    </dbReference>
    <dbReference type="GeneID" id="66493993"/>
    <dbReference type="eggNOG" id="ENOG503322G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014245">
        <property type="entry name" value="Spore_III_AF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09581">
        <property type="entry name" value="Spore_III_AF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN82137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP07751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL31745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="188" mass="22033" checksum="CCEF9FF93A7A742C" modified="2016-09-07" version="1">MKEELYLWIRNLAVFYIFFTAVLNLIPDQKYEKYVRFFMGLLLIFMMSTPIFSILGKGSELTESFLDNFSEENREKELREFQNIQKVYLEKGYELELEQKIRETLEKRGIEVYKVKVNIEGEETQANLVLKTEISQEERKELKDALVEEWGLKENRICIQIVRNESGKMGNPVAHRSTSGSSGDACIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A2E9</accession>
    <name>A0A174A2E9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="6">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fabG_1</name>
        <name evidence="8" type="synonym">fabG</name>
        <name evidence="9" type="synonym">fabG_4</name>
        <name evidence="9" type="ORF">BWLFYP14_03092</name>
        <name evidence="7" type="ORF">ERS852478_01142</name>
        <name evidence="8" type="ORF">GT712_03475</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199938.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81665">
        <property type="protein sequence ID" value="CUN81665"/>
        <property type="gene ID" value="ERS852478_01142"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 6" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0753">Steroid metabolism</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="11"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="62"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN81665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS88172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="246" mass="26297" checksum="3386D5187C77D33C" modified="2016-09-07" version="1">MLKNKIVLITGAGRGIGRAIAIALAKEGAEVVINYNGSEERAKEVKQTIEENGGKASIYKCNVSDFAACEAMIKDIVKEYGHLDILVNNAGITKDGLIMKMKEEDFDSVLNVNLKGTFNTIRHSARQMLKQRSGKIINISSVSGILGNVGQANYAASKAGVIGLTKTMARELGSRGITVNAIAPGFVDTEMTEVLSEEIRENACKQIILGRFGKPEDIANTAVFLASDKADYITGQVISVDGGMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AHU0</accession>
    <name>A0A174AHU0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-dependent butanol dehydrogenase A</fullName>
            <ecNumber evidence="4">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bdhA</name>
        <name evidence="4" type="ORF">ERS852478_01297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200007.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88261">
        <property type="protein sequence ID" value="CUN88261"/>
        <property type="gene ID" value="ERS852478_01297"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1979">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990362">
        <property type="term" value="F:butanol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08187">
        <property type="entry name" value="BDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044731">
        <property type="entry name" value="BDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43633">
        <property type="entry name" value="PTHR43633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="3">
        <location>
            <begin position="9"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN88261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="394" mass="43657" checksum="7B95313D9A749A0B" modified="2016-09-07" version="1">MRNFEYYTPTQVLFGKDTHLQAGSLLKKYGAKKVLIHYGGQSAVRSGLIDEITSNLKEEGLEYITLGGVIPNPLLSKVREGIELCQKEHVDFILAVGGGSVIDSSKAIGYGVANPNNDVWDFCLKKAVPTGCLPIGVILTIAASGSEMSSSSVITNEETKEKRGCAKTDYCRPKFAILNPRLTYTLPQYQTESGCVDILMHTMERYFVNIETMEITDSISEALMQTVIYNARILMKEPDNYSARAEIMWAGSLSHNGLTGCGTGGGDWACHQLEHELGGVYNVTHGAGLAAIWGSWARYVYEVNPERFAQFATNVFDIPCGTDYKETALAGIEAMENFFRSVEMPTSLHELGLDLTDQQIHDLAFKCSFEDTRTIGIFKQLNMRDMEKIYLMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AMW9</accession>
    <name>A0A174AMW9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lysophospholipase L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200026.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89912">
        <property type="protein sequence ID" value="CUN89912"/>
        <property type="gene ID" value="ERS852478_01343"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="28"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN89912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="307" mass="34728" checksum="16859F5999268786" modified="2016-09-07" version="1">MKYESSFKSEADGLEISVMALMPDKKPYRAVVQLVHGMSEHKERYIPFMQYLAKLGYVVVIHDHRGHGKSVKHQDDLGFTYGGGAQAMLQDIRTVNRKIHAYYPELPLILMGHSMGSLAVRAFVAEHDSCVDMLIVCGSPSYNTAMPLGVAIAKTEKAVFGPRHRSKLIETMSFGAGAMKFRKDKRCTAWICSDPDVAKEYEESEMCGFTFTDDAYLALFELMKRAYDVEHFSCTNPDMPVLFVSGAEDPCLINVRHFAKTVRAMRRAGYKDVKGKLYPGMRHEILNEIGREQVYHDIAAYMRKKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AQB4</accession>
    <name>A0A174AQB4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjO_7</name>
        <name evidence="7" type="ORF">ERS852478_01335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89668">
        <property type="protein sequence ID" value="CUN89668"/>
        <property type="gene ID" value="ERS852478_01335"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="70"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN89668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="292" mass="32858" checksum="1584A5AA8BD784BE" modified="2016-09-07" version="1">MTISKKSMKWIPWLLVLPVVIIRGFTTLYPILMTVRNSFFDIKILSGINEFCGIQNYLKIFSDPKVLTSIRFTVIFVVVSMIFHVILGVGLALILNMKFKGRRFLRTIVLIPWAMPAVVVGMAAKWAFNNDYGLINDFIRLFVHGYQNSWLINTGSARAAVIAVDLWKDLPFFAILVLSGLQFISGDIYEAAKVDGANGIQCFFRITLPLILKNVLTLSIPFTLWRLTTFDIVYSMTSGGPGEDTALIAYRITTEAFTNLNVGYASALAMLLFVVMAVFSWLNIRVMNKIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AS26</accession>
    <name>A0A174AS26_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_00725</name>
        <name evidence="2" type="ORF">ERS852478_01359</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000018">
        <property type="protein sequence ID" value="VUX62976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580445.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000055.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90320">
        <property type="protein sequence ID" value="CUN90320"/>
        <property type="gene ID" value="ERS852478_01359"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN90320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX62976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="204" mass="21553" checksum="405E5FD8BD7D1F48" modified="2016-09-07" version="1">MNTQNSTITKLAETALMAALCYVSFTFLQIKIPVPGGDATSIHIGNAFCVLAALLIGGVYGGLSGAIGMGIADLMDPVYITGAPKTFVLKFCIGLITGLVAHKIAKINESTDKKYVFKWSVIASVAGLAFNVVADPIVGYFYKQYILGQPQELAQALAKMSAVATLFNAVVSVILVAVIYNAVRPVLIKSHLLTITGKKKEQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AS77</accession>
    <name>A0A174AS77_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Manganese transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mntR_3</name>
        <name evidence="3" type="ORF">ERS852478_01371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200039.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90729">
        <property type="protein sequence ID" value="CUN90729"/>
        <property type="gene ID" value="ERS852478_01371"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe_dep_repr_C" evidence="2">
        <location>
            <begin position="95"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN90729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="299" mass="35138" checksum="8C5489A324B46A21" modified="2016-09-07" version="1">MKKRMQTDFEEIKETDTQLPSSRREIEEDMLEQICLIANAGAEITVEELGGRMNMSRREVNFYLKQLKTHGYVVREKDTYTGLQGRRAESGIFLTELGKITGEEFQYRHEILTQFLQFVGVSEEKAKEDACRMEHVISEETVQQICNFVDYGNTFERILKQSDLRSWYRPGRYQFLMGIYQIEKTCPRRFAREFKHFSENICLNVTEDESSFELIKREGEASSQNLWYKDPEQGWIQAEERMGNPRIPSGAFKFLTRCQDPIIEGVALIAFTRKGEKPVDWNSRELDVHIWKSEDKGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AVD3</accession>
    <name>A0A174AVD3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VanZ family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">VanZ like family</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">VanZ like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_00998</name>
        <name evidence="3" type="ORF">ERS852478_01387</name>
        <name evidence="4" type="ORF">GT712_13145</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN92507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000026">
        <property type="protein sequence ID" value="MZS89992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058655.1">
        <property type="nucleotide sequence ID" value="NZ_JADPCB010000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN92507">
        <property type="protein sequence ID" value="CUN92507"/>
        <property type="gene ID" value="ERS852478_01387"/>
    </dbReference>
    <dbReference type="GeneID" id="66492621"/>
    <dbReference type="eggNOG" id="COG4767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="50"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN92507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX63512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="186" mass="20648" checksum="9ECAF24DD9F9F099" modified="2016-09-07" version="1">MDIYQIIITHNRSWTIREIIAFAVVFLMAVFLAAVLLRLHKIVIIQAVCGLLLLTFLSIVFGSTVFTRTPGIRQYQPEVFWSWKEILGIGTCGRLGSTTGDGLLQENLLNILLLFPAGILLPGVTGRKLKWWMGLLVGIAVSSAIEISQLLLCRGLFEFDDIIHNSLGCMLGSLLGNRMLRLVHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AVR2</accession>
    <name>A0A174AVR2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, y4mF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN92682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200052.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN92682">
        <property type="protein sequence ID" value="CUN92682"/>
        <property type="gene ID" value="ERS852478_01393"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN92682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="67" mass="7572" checksum="C7973438039D73E1" modified="2016-09-07" version="1">MATTLNVSQRVKDARCDANLTQTELGRKIGKSKQWVSELERGNIRLSYEMAVVISEVCNKSTDFFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AXS8</accession>
    <name>A0A174AXS8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN92769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN92769">
        <property type="protein sequence ID" value="CUN92769"/>
        <property type="gene ID" value="ERS852478_01396"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN92769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="54" mass="6224" checksum="F8D78A494981FA10" modified="2016-09-07" version="1">MLTTEDVKKYHATVERILNALDNSPVPISWRKMDRCALQSVIAKELILIDKEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B0C7</accession>
    <name>A0A174B0C7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200078.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93669">
        <property type="protein sequence ID" value="CUN93669"/>
        <property type="gene ID" value="ERS852478_01425"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="1">
        <location>
            <begin position="135"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN93669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="190" mass="21907" checksum="45183D31AE2A8087" modified="2016-09-07" version="1">MDTEKKVQFVALTKEEIDAMIQQAALAGAQVASDAMMVGQRKSEKEKIDRRLHNTDLLLRNYRTLKASYENAVYKSKEGEVTEVLEDIMTMKDDKVIVESIKTSAKRTAIMVQHIDKMLDVYRIYCSKLSEKDKRRYKIIKALYISKTPMTIAEISKKFSVSKVTVYEDIKIAKERLSSLFFGIDGLRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B0G6</accession>
    <name>A0A174B0G6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mu-like prophage protein gp29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200146.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93893">
        <property type="protein sequence ID" value="CUN93893"/>
        <property type="gene ID" value="ERS852478_01433"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN93893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="455" mass="51983" checksum="133C775484382952" modified="2016-09-07" version="1">MKEYGRIGQKRWEGVFNEEFLPELSGIRGIKTYREMLDNDDTIGAIMFAIKMLIRQVKWHVEPGGDSAKDREAAEFVESCMDDMQNTWTDTISEILSFLAYGWSFHEIVYKRRMGKTKNRKTSSKYSDGLIGWQKIPPRAQDTLYRWEYDDKDNLIGMTQQPPPDYGLLTIPISKAMLFRTESIKDNPEGRSILRNAYRSWYFKRRIQEIEAIGIERDLAGLPVLHAPDGVDIWDDKDPELVSINAALTSMVKNIRRNEYEGLVLPAGYEAELLSTGGTRQFDTNAIINRYDAKIAQTVMADFIMLGHEQTGSFALSEDKTELFAVALGAFLDVICETFNNQGIPSLIDMNGAHFDAITDYPQLAHGDVDKRDITKLSTFLKDMVGVGILIPDEDLEDYVREVANLPERTLSDDPRNKDEQREAQRRSPEKEGKTSEVEPEENQEIEEAKKRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B4A2</accession>
    <name>A0A174B4A2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200097.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94556">
        <property type="protein sequence ID" value="CUN94556"/>
        <property type="gene ID" value="ERS852478_01453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN94556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="114" mass="12573" checksum="12ED30FEFC2542A5" modified="2016-09-07" version="1">MAYDSNDGVARLAAVLDARMKDHADKPLCLDFAEIQADGSLLSNTFPIPHNDYRVCRQLTIGKTGDAFCDVRADEHSGKAYLPESMRQLQAGDRVLIAWVQDTAVVIDIITRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B692</accession>
    <name>A0A174B692_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4'-phosphopantetheinyl transferase sfp</fullName>
            <ecNumber evidence="3">2.7.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sfp_2</name>
        <name evidence="4" type="synonym">sfp_1</name>
        <name evidence="4" type="ORF">BWLFYP14_00990</name>
        <name evidence="3" type="ORF">ERS852478_01488</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380989.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95739">
        <property type="protein sequence ID" value="CUN95739"/>
        <property type="gene ID" value="ERS852478_01488"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="99"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN95739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX63504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="215" mass="24717" checksum="540A537945BD5148" modified="2016-09-07" version="1">MQKLYRININHFEDPLKNERLLDLVGIRRREKVIRYRMPDDRKRSLGAGIIIRKILDENGLTESCLRYSDNEKPVVDGLFFNVSHAGDYVVGVLSDCEVGCDIEKNANAPLEVAEHYFYHSELAYIKAAKNKDKAFFTLWTLKESYMKMTGRGMSLPLDSFEVVPTAEGFVLGKSSERPCFFETMEFDGYIFSVSSERAFSLHNPLEIAFDDIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B823</accession>
    <name>A0A174B823_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase family B, exonuclease domain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Predicted exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_00989</name>
        <name evidence="2" type="ORF">ERS852478_01489</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380990.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95778">
        <property type="protein sequence ID" value="CUN95778"/>
        <property type="gene ID" value="ERS852478_01489"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN95778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX63503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="341" mass="39767" checksum="1B0229E4C6F5B824" modified="2016-09-07" version="1">MIVKKMPILQGFPDFETVKFFTGKFFQKYNFTPVFYDIETTGLSRNSTYLYLIGAVGIEDETWNFYQWMAENASEEETILRIFSQFLQQYNLMISYNGERFDQPYLEARYEKYGIPSPFTGKQSLDLYLTLKPLKSLLKLSAMKQPCMEEFLGIKDRIYDNGKECIKLYKDFLKKRDAFTADEILGHNLEDVLGLGRIFDMLGYLCIYDGDYEVTYSEFDGDNLILKLKLPCTLPQEFSNGNTDFYLTGKDEEINLIIKTTDGKLKQYYADYKDYYYLPEEDTVIPKSLGSGIDRKHRKAATKNTCYTWFTCSDAFLSSPVQQKQYLTYTLSCLIGTLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BML7</accession>
    <name>A0A174BML7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4'-phosphopantetheinyl transferase sfp</fullName>
            <ecNumber evidence="3">2.7.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sfp_3</name>
        <name evidence="3" type="ORF">ERS852478_01607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057317.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00816">
        <property type="protein sequence ID" value="CUO00816"/>
        <property type="gene ID" value="ERS852478_01607"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="127"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO00816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="232" mass="26816" checksum="8AEC31CFBD58441A" modified="2016-09-07" version="1">MEIKRYGEKEFLSADKLYIRENEIHIWCIRWPEMTDFWKNHEYILSGQELEQAGRFRFPEDRMRYIAGKVVVRILLKRYLDMETIDFSVNELGKPYHKEIAGKQTVNFNISHSGEFILEGFAVGMDIGVDVQEMAGCPDYREIAGNFYTAEEAEDVINEGPELFFQYWAAKEAYVKAIGIGLGRGMDFFSVRNGEITEKGRKGQGWHLYPVKIEGYAAYVAAHKKGDKSNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BP95</accession>
    <name>A0A174BP95_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative multidrug export ATP-binding/permease protein SAV1866</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852478_01619</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_024720762.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01366">
        <property type="protein sequence ID" value="CUO01366"/>
        <property type="gene ID" value="ERS852478_01619"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="25"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="339"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="372"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO01366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="581" mass="63214" checksum="E26EFBDF76FB2D88" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CEQ3</accession>
    <name>A0A174CEQ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01887</name>
        <name evidence="3" type="ORF">GT712_19100</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="ERS852478_01887"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO11407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS91086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="71" mass="7729" checksum="CBAE4B46B8CC6CA9" modified="2016-09-07" version="1">MLSLLFTICMIWFVGKLFAFGLKASWGIMKLLCTVIFFPVILIGMVLGGLMYIAFPLLIVGGIVALATSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CF61</accession>
    <name>A0A174CF61_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative HTH-type transcriptional regulator ywnA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ywnA_3</name>
        <name evidence="1" type="ORF">ERS852478_01860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10600">
        <property type="protein sequence ID" value="CUO10600"/>
        <property type="gene ID" value="ERS852478_01860"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO10600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="140" mass="15248" checksum="A2803A72714CA9FD" modified="2016-09-07" version="1">MIVDSSFNLAVHALVCLSHSGRSLSSEALAENICTNPTRVRRVLTGLKKAGMVEIREGLDGGYRLTADPATLSLRQVAEAVNTRFVDCAWHSGDIDRDCAICSGMAGVIDALYRSMNEECAAYLSHITITDIEKQLFTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CFC7</accession>
    <name>A0A174CFC7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate kinase</fullName>
            <shortName evidence="2">SK</shortName>
            <ecNumber evidence="2">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroK_1</name>
        <name evidence="2" type="synonym">aroK</name>
        <name evidence="3" type="ORF">ERS852478_01902</name>
        <name evidence="4" type="ORF">GT712_17535</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000051">
        <property type="protein sequence ID" value="MZS90810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381300.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11854">
        <property type="protein sequence ID" value="CUO11854"/>
        <property type="gene ID" value="ERS852478_01902"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO11854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="174" mass="19802" checksum="7303A889EC1F44CB" modified="2016-09-07" version="1">MNHIVIIGFMGSGKTRVGKRLAKDFNLPFVDVDRVVSKKMNLTMKEIFDRFGEPFYRALETTVIKALIDDPEQKIISLGSGLPMQEQNAKYIKKLGTIVYLKGSYATLKKRLENSSSNPLIEGEDKEDKIRKLLKQRDPVYAKFADVEMITGDKPFEDLIAQLEEKLKTCVKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CX25</accession>
    <name>A0A174CX25_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">rimP</name>
        <name evidence="10" type="ORF">BWLFYP14_00447</name>
        <name evidence="6" type="ORF">ERS852478_02027</name>
        <name evidence="7" type="ORF">ERS852523_00054</name>
        <name evidence="9" type="ORF">GT712_10170</name>
        <name evidence="8" type="ORF">GT728_08795</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RimP family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO95590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000018">
        <property type="protein sequence ID" value="MZS89423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707593.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2220"/>
    <dbReference type="EnsemblBacteria" id="CUO16629">
        <property type="protein sequence ID" value="CUO16629"/>
        <property type="gene ID" value="ERS852478_02027"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95590">
        <property type="protein sequence ID" value="CUO95590"/>
        <property type="gene ID" value="ERS852523_00054"/>
    </dbReference>
    <dbReference type="GeneID" id="66495647"/>
    <dbReference type="eggNOG" id="COG0779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DUF150" evidence="4">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="DUF150_C" evidence="5">
        <location>
            <begin position="89"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO16629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO95590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL33289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX62376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="154" mass="17863" checksum="0C4A7D3B7CE645BD" modified="2016-09-07" version="1">MSRREEYEKRAEELLAPIVELNGFELVDVEYVKEAGNWYLRGYIDKPGGITVNDCETVSRAFSDKLDENDFIEDSYIMEISSPGLDRPLKKDKDFERNMGKLVEIRTYRPIEKQKEFCGILTAYDSNSVTIDEDGTERVFDKKDTALIRLAIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CZF4</accession>
    <name>A0A174CZF4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BWLFYP14_02400</name>
        <name evidence="6" type="ORF">ERS852478_02044</name>
        <name evidence="7" type="ORF">ERS852523_00045</name>
        <name evidence="8" type="ORF">GT712_14020</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">2789STDY5834863</strain>
            <strain evidence="7 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO95383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000030">
        <property type="protein sequence ID" value="MZS90158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX66029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707623.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2212"/>
    <dbReference type="EnsemblBacteria" id="CUO17165">
        <property type="protein sequence ID" value="CUO17165"/>
        <property type="gene ID" value="ERS852478_02044"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95383">
        <property type="protein sequence ID" value="CUO95383"/>
        <property type="gene ID" value="ERS852523_00045"/>
    </dbReference>
    <dbReference type="GeneID" id="66492639"/>
    <dbReference type="eggNOG" id="COG4905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010540">
        <property type="entry name" value="CmpB_TMEM229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06541">
        <property type="entry name" value="ABC_trans_CmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO17165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO95383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS90158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="128" mass="14316" checksum="EBD8734682786198" modified="2016-09-07" version="1">MKKAFILCGLTGWCMEILWTGLHSILSGELTMTGKTSLLMFPIYGCGAIIRPLSGKLSAVPLFVRGCIYTVGFFFVEFISGALLRCFHMCPWDYSNTPLNYRGLIRPDYAPLWFGAGLFFEKILGKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D0L0</accession>
    <name>A0A174D0L0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19202">
        <property type="protein sequence ID" value="CUO19202"/>
        <property type="gene ID" value="ERS852478_02090"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50336SH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019633" evidence="2">
        <location>
            <begin position="27"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO19202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="315" mass="34946" checksum="548C01A2F8BE5930" modified="2016-09-07" version="1">MKKKVVTAFMMAALGSSLVFSQAVMAADTTAKTETSEDADKDATESEDKDVAEDADKADEEKEDLKTIGEKPEEDTEGVFSVKLKNLTGKVITGVTVKNEKDEEYPDNFLKEEDKFEADEERVLWFDPNAKDKADEENKDSSDDAKETTDTEETKTEDAKTDEKAEGEDKDDAEKEIPKYNIQLTFEDGTTAEIHTFPFGDTEEAELHLEGEVAYLVFDSISQKKEYNTLETEKALAPKPTEAAAQAASETTQSYDNSSDYSNDYDYNNDYDYSNDYDYSNDYDYGNDDSGDYDGSDDGGSDDGGDGCLDNGLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D1F0</accession>
    <name>A0A174D1F0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200550.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19273">
        <property type="protein sequence ID" value="CUO19273"/>
        <property type="gene ID" value="ERS852478_02092"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033RQD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019660" evidence="1">
        <location>
            <begin position="33"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO19273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="222" mass="24645" checksum="6270CD873181108E" modified="2016-09-07" version="1">MKKTKRFLAVVLCMLLMLTPLAVVAETVTVQAAEPQTVKVKLDKKTGKRYGYDGNNQKVTQQWGVTAKGFRYYFGKNGAAYQADQDMVGKYGILMKKINGKYYGFDVSGHTVKGIRVGSVSMYEIPKLYYFNPKTGAVDKKKTSLYRKYAATSTLAKQNNASKIKKVLGKYKKCTISKGNTCMLDGNGKDVTYTYDYVQLNVVRPTGKGSSAEVVASITVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DGW5</accession>
    <name>A0A174DGW5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005428610.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24841">
        <property type="protein sequence ID" value="CUO24841"/>
        <property type="gene ID" value="ERS852478_02256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO24841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="136" mass="15588" checksum="5C9A7079C001284D" modified="2016-09-07" version="1">MCKKRKIITITVLFVLGVAVSYLQWGREIDVVGSMGTSSENFHEEHVTFTLNRLIITDKEKCAEEIIKKCRENDFASTLFSYDVAKPNALYGTVYRSRFSMKGQKPLFHFRYTQTADTLGSYNIVDDPEAFTLVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DI54</accession>
    <name>A0A174DI54_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purE_1</name>
        <name evidence="3 9" type="synonym">purE</name>
        <name evidence="8" type="synonym">purE_2</name>
        <name evidence="11" type="ORF">BWLFYP14_01480</name>
        <name evidence="7" type="ORF">ERS852478_02227</name>
        <name evidence="8" type="ORF">ERS852523_02428</name>
        <name evidence="10" type="ORF">GT712_11635</name>
        <name evidence="9" type="ORF">GT728_09360</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000025">
        <property type="protein sequence ID" value="CUP67883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000018">
        <property type="protein sequence ID" value="MZL33400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000022">
        <property type="protein sequence ID" value="MZS89706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705484.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000042_gene3029"/>
    <dbReference type="EnsemblBacteria" id="CUO24029">
        <property type="protein sequence ID" value="CUO24029"/>
        <property type="gene ID" value="ERS852478_02227"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP67883">
        <property type="protein sequence ID" value="CUP67883"/>
        <property type="gene ID" value="ERS852523_02428"/>
    </dbReference>
    <dbReference type="GeneID" id="66493792"/>
    <dbReference type="eggNOG" id="COG0041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO24029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP67883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS89706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX64627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="166" mass="17658" checksum="34B736B00306529A" modified="2016-09-07" version="1">MAKVGIVMGSDSDMPIMSKAADILEKLGIDYEIKIISAHREPDVFFEYAKTAEEKGFKVIIAGAGMAAHLPGMCAAIFPMPVIGIPMHTTSLGGRDSLYSIVQMPSGIPVATVAINGGANAGLLAAKILATSDEELLAKLKAYSQELKEQVEAKDARLQEVGYKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DL66</accession>
    <name>A0A174DL66_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24630">
        <property type="protein sequence ID" value="CUO24630"/>
        <property type="gene ID" value="ERS852478_02250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO24630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="651" mass="72470" checksum="53E535DDBFD5CDCF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DLD1</accession>
    <name>A0A174DLD1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein</fullName>
            <shortName evidence="2">P2TMN nickel insertion protein</shortName>
            <ecNumber evidence="2">4.99.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nickel-pincer cofactor biosynthesis protein LarC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">larC</name>
        <name evidence="4" type="ORF">ERS852478_02292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide</text>
            <dbReference type="Rhea" id="RHEA:54784"/>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <dbReference type="ChEBI" id="CHEBI:137372"/>
            <dbReference type="ChEBI" id="CHEBI:137373"/>
            <dbReference type="EC" id="4.99.1.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LarC family.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.12" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200687.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26007">
        <property type="protein sequence ID" value="CUO26007"/>
        <property type="gene ID" value="ERS852478_02292"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01074">
        <property type="entry name" value="LarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002822">
        <property type="entry name" value="Ni_insertion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36566">
        <property type="entry name" value="PTHR36566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01969">
        <property type="entry name" value="DUF111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00299">
        <property type="entry name" value="TIGR00299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 2" id="KW-0533">Nickel</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="3">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO26007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="450" mass="50383" checksum="41E5084BE62D8D8F" modified="2016-09-07" version="1">MGKTLYLECYSGISGDMTVAALLDLGADRSVLDRVLKSLKVSGFETKISRVVKSGIDACDFDVVLDKEHENHDHDMEYLHGHHHEGRECNHAHGTGTAQDHHHHEHRGIKEITYIIEHSAMTENAKKIALRIFEILAEAESKAHNVPVDQVHFHEVGAVDSIVDIVSVAVCLDDLDVTEVIVPVLCEGRGTVRCQHGILPIPVPAVANIVSANHLHLKMTEVEGELVTPTGAAIVAAVKTKDKLPETFEIQKIGIGAGKRQYECPGILRAMIISQSAEIDEEKAQTEEFKNPEIGNNPKAENQETKDTIIKMETNIDDCSGEVLGFVMERLMKAGARDVHYVPVFMKKNRPAWVLNVICKEEDMETLQNIIFEETTTIGIRYSIMERTILPRETRTLPTPWGEVQVKVCTLNGKEQLYPEYESVAQLSREKEIPFTEIYRYIVLANKDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DLP2</accession>
    <name>A0A174DLP2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-ribose pyranase</fullName>
            <ecNumber evidence="2">5.4.99.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fucU</name>
        <name evidence="7" type="ORF">BWLFYP14_01551</name>
        <name evidence="4" type="ORF">ERS852478_02305</name>
        <name evidence="5" type="ORF">ERS852523_01636</name>
        <name evidence="6" type="ORF">GT728_12200</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">2789STDY5834863</strain>
            <strain evidence="5 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-ribopyranose = beta-D-ribofuranose</text>
            <dbReference type="Rhea" id="RHEA:25432"/>
            <dbReference type="ChEBI" id="CHEBI:27476"/>
            <dbReference type="ChEBI" id="CHEBI:47002"/>
            <dbReference type="EC" id="5.4.99.62"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.4.99.62" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP44348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000029">
        <property type="protein sequence ID" value="MZL33940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708382.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000081_gene3043"/>
    <dbReference type="EnsemblBacteria" id="CUO26413">
        <property type="protein sequence ID" value="CUO26413"/>
        <property type="gene ID" value="ERS852478_02305"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP44348">
        <property type="protein sequence ID" value="CUP44348"/>
        <property type="gene ID" value="ERS852523_01636"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062193">
        <property type="term" value="F:D-ribose pyranase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023750">
        <property type="entry name" value="RbsD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007721">
        <property type="entry name" value="RbsD_FucU"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05025">
        <property type="entry name" value="RbsD_FucU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102546">
        <property type="entry name" value="SSF102546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO26413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP44348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL33940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX64697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="147" mass="16416" checksum="C289C07D3FA98409" modified="2016-09-07" version="1">MLKGIPEILSPELLKVLCEMGHSDRLVIADGNFPVESMGKNAITIRCDGHGVPEILDAILKLFPLDTYVEHPVNLMEVMPGDNVETPIWDTYKEIVAKYDERGDKAVGNIERFAFYEEAKTAYCIISTSEKALYANIMLQKGVVINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DM11</accession>
    <name>A0A174DM11_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">L-fucose isomerase</fullName>
            <shortName evidence="7">FucIase</shortName>
            <ecNumber evidence="7">5.3.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-deoxy-L-galactose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">fucI</name>
        <name evidence="14" type="ORF">BWLFYP14_01552</name>
        <name evidence="11" type="ORF">ERS852478_02306</name>
        <name evidence="12" type="ORF">ERS852523_01635</name>
        <name evidence="13" type="ORF">GT712_12830</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">2789STDY5834863</strain>
            <strain evidence="12 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="13 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Converts the aldose L-fucose into the corresponding ketose L-fuculose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-fucose = L-fuculose</text>
            <dbReference type="Rhea" id="RHEA:17233"/>
            <dbReference type="ChEBI" id="CHEBI:2181"/>
            <dbReference type="ChEBI" id="CHEBI:17617"/>
            <dbReference type="EC" id="5.3.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the L-fucose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.25" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP44317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381348.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000081_gene3042"/>
    <dbReference type="EnsemblBacteria" id="CUO26444">
        <property type="protein sequence ID" value="CUO26444"/>
        <property type="gene ID" value="ERS852478_02306"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP44317">
        <property type="protein sequence ID" value="CUP44317"/>
        <property type="gene ID" value="ERS852523_01635"/>
    </dbReference>
    <dbReference type="GeneID" id="66494423"/>
    <dbReference type="eggNOG" id="COG2407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00563">
        <property type="reaction ID" value="UER00624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008736">
        <property type="term" value="F:L-fucose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042355">
        <property type="term" value="P:L-fucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.14.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01254">
        <property type="entry name" value="Fucose_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038393">
        <property type="entry name" value="Fuc_iso_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015888">
        <property type="entry name" value="Fuc_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038391">
        <property type="entry name" value="Fucose_iso_dom1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012888">
        <property type="entry name" value="Fucose_iso_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005763">
        <property type="entry name" value="Fucose_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038392">
        <property type="entry name" value="Fucose_isomerase_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012889">
        <property type="entry name" value="Fucose_isomerase_N2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02952">
        <property type="entry name" value="Fucose_iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07881">
        <property type="entry name" value="Fucose_iso_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07882">
        <property type="entry name" value="Fucose_iso_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01089">
        <property type="entry name" value="fucI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="4 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucose_iso_N1" evidence="9">
        <location>
            <begin position="10"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Fucose_iso_N2" evidence="10">
        <location>
            <begin position="181"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Fucose_iso_C" evidence="8">
        <location>
            <begin position="397"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO26444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP44317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS89932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX64698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="598" mass="66346" checksum="DFBEE8DAD224B0D0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E909</accession>
    <name>A0A174E909_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6449 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380892.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33218">
        <property type="protein sequence ID" value="CUO33218"/>
        <property type="gene ID" value="ERS852478_02497"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045611">
        <property type="entry name" value="DUF6449"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20047">
        <property type="entry name" value="DUF6449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6449" evidence="2">
        <location>
            <begin position="448"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO33218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="685" mass="77086" checksum="73E77A7FBB1C369D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EAK6</accession>
    <name>A0A174EAK6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33020">
        <property type="protein sequence ID" value="CUO33020"/>
        <property type="gene ID" value="ERS852478_02488"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO33020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="110" mass="12482" checksum="20566204F1DAEC62" modified="2016-09-07" version="1">MGGGIYPNMLCAHPPFQIDGNFGFAVAEMLIQSRKGYILLLPALPDEWKDGKVRGMKAQGDITVDFEWREGRIHRVRLCSSHEQKVTLECNGISKTVFLKPDRTENMIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ECR0</accession>
    <name>A0A174ECR0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacterial protein of uncharacterized function (DUF961)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003062614.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35127">
        <property type="protein sequence ID" value="CUO35127"/>
        <property type="gene ID" value="ERS852478_02549"/>
    </dbReference>
    <dbReference type="GeneID" id="60884227"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010365">
        <property type="entry name" value="DUF961"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038620">
        <property type="entry name" value="YdcP-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06125">
        <property type="entry name" value="DUF961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO35127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="127" mass="14186" checksum="C21FDD0661BBC8A1" modified="2016-09-07" version="1">MRLSNGFVIDKEKTFGELKFTAVRDVFLQNEDGTPSTQLKKRIYDLKCSLHGGIIPVSVPPEVPVREFPYNAVVELVNPVADTVSRKTYTGADVDWYVKAEDIVLKNKGNQNAGNPQNHVPQGQMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EFH7</accession>
    <name>A0A174EFH7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inner membrane lipoprotein YiaD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yiaD</name>
        <name evidence="4" type="ORF">ERS852478_02602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200801.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36662">
        <property type="protein sequence ID" value="CUO36662"/>
        <property type="gene ID" value="ERS852478_02602"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="3">
        <location>
            <begin position="150"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO36662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="310" mass="35175" checksum="7DF91ACE82EB9F1F" modified="2016-09-07" version="1">MRKRKKSEEGGFNVWRSYSDMMAGVLLLFILIMCVTLFQAQKSYNESIKERDDKIALQEQYTAEILAQQSELDEKNSKLSSQDEQLDKQKKLLAELAAQLKEQQASLDEKTSLLATQQKKIDNIIGVKADVIEALQKEFSKNNVSVDIDSQTGALTLNANVLFDYDKSELTDEGKQELADILPIYCKVLLQKDYKKYLAEIIIDGYTDTDGDYDYNLELSQKRSLAVAQYLTEIRENFLSSDEISELQNYLTVNGHGSANPVLDSDGNVDKDASRRVEVKFRLKDDEMINELNQIMNTDKTSDSEKSGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ET00</accession>
    <name>A0A174ET00_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Maltose/maltodextrin transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">malF_3</name>
        <name evidence="12" type="ORF">ERS852478_02670</name>
        <name evidence="14" type="ORF">GT712_04805</name>
        <name evidence="13" type="ORF">GT728_17890</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="13 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">BIOML-A1</strain>
            <strain evidence="14 16">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO39095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000063">
        <property type="protein sequence ID" value="MZL34994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000007">
        <property type="protein sequence ID" value="MZS88424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_044996454.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39095">
        <property type="protein sequence ID" value="CUO39095"/>
        <property type="gene ID" value="ERS852478_02670"/>
    </dbReference>
    <dbReference type="GeneID" id="66492666"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030156">
        <property type="entry name" value="MalF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47314:SF1">
        <property type="entry name" value="PTHR47314:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="237"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO39095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL34994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS88424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="486" mass="54480" checksum="25BDBF71CAA590E8" modified="2016-09-07" version="1">MAAQDNNSAAAAVSGFFKSIGGFFADFGTAVVKGDAFVKLSLIWMGAGYAKRKQYVKAVLMTLLEIAVIVFSVKFAMQYVPKFSTLGTVKMEKVFNMKTMKSEFNDYDNSFTILLFSLFSFVVWFAAAVVWFKNVINAYTLQKMEEAGKHINTFKEDLRSLTEEKFHITLLTLPVLGVVIFTLIPILLLIFVAFTNYDQQHMPPTELFSWVGFSNFISLFGGGGLTSTFGYAFVRVLGWTLVWAFFATFTTYIGGILLSLLLNSKKTRLSKMWRTLFIVTIAVPQFVSLLLVRNFFSNGGIVNTICHSIGLTGFLRSIGLVSTSYIPFLSAPGWAHVMIILINIWIGVPYQMLIATGVLMNLPSDQLESARVDGATNFQIFRKITMPYLLFVTGPALITDFVKNINNFNVIYLLTQDVYTTTNQAMASSQAKEVDLLVTWLFRLTQDYYNYKMASAIGIIVFIICAVFTLVAFNRMIKGDKEGTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ETH5</accession>
    <name>A0A174ETH5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="4">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cobB_2</name>
        <name evidence="4" type="synonym">cobB</name>
        <name evidence="6" type="ORF">ERS852478_02738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sirtuin family. Class U subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200871.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41253">
        <property type="protein sequence ID" value="CUO41253"/>
        <property type="gene ID" value="ERS852478_02738"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01968">
        <property type="entry name" value="Sirtuin_ClassU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028628">
        <property type="entry name" value="Sirtuin_class_U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="103"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="189"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO41253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="240" mass="27026" checksum="A91E14B93025D8C2" modified="2016-09-07" version="1">MAGEVERLQELVDKYDNIVFFGGAGVSTESGIPDFRSQDGLYHQKYDYPPETILSHTFFMRKPEEFFKFYRDKMLCDTAKPNAAHLKLAELEQAGKLKAVITQNIDNLHQMAGSKKVLELHGSVYRNYCMKCHRFYDFAHMKASTGVPRCECGGIIKPDVVLYEEGLDNQTINEAVKAISEAQVLIIGGTSLAVYPAAGLIDYFRGEHLVVINKSPTPRDRYADLLIQEPIGQVFSQIHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EVT0</accession>
    <name>A0A174EVT0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytidine deaminase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">tRNA-specific adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BWLFYP14_00591</name>
        <name evidence="5" type="ORF">ERS852478_02714</name>
        <name evidence="6" type="ORF">ERS852523_02544</name>
        <name evidence="7" type="ORF">GT712_09745</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
            <strain evidence="6 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000027">
        <property type="protein sequence ID" value="CUP70998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000017">
        <property type="protein sequence ID" value="MZS89344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000135_gene971"/>
    <dbReference type="EnsemblBacteria" id="CUO40619">
        <property type="protein sequence ID" value="CUO40619"/>
        <property type="gene ID" value="ERS852478_02714"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP70998">
        <property type="protein sequence ID" value="CUP70998"/>
        <property type="gene ID" value="ERS852523_02544"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO40619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP70998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS89344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX62813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="163" mass="18346" checksum="7F474A28AE5CCE67" modified="2016-09-07" version="1">MDVNHKRTDYLSWDEYFMGVAMMSGMRSKDPNSQVGACIVSEDNKILSMGYNGFPKGCSDDEFPWAREGDSLHTKYFYVTHSELNAILNYRGGSLEGAKLYVSLFPCNECAKAIIQAGIKTIVYDCDKYADTPAVIASKRMLDAAGVRYYKYNRTGRKITIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EXP9</accession>
    <name>A0A174EXP9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CysO-cysteine peptidase</fullName>
            <ecNumber evidence="7">3.4.17.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mec</name>
        <name evidence="11" type="ORF">BWLFYP14_01074</name>
        <name evidence="7" type="ORF">ERS852478_02778</name>
        <name evidence="8" type="ORF">ERS852523_02213</name>
        <name evidence="10" type="ORF">GT712_06960</name>
        <name evidence="9" type="ORF">GT728_15805</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.17.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000022">
        <property type="protein sequence ID" value="CUP61671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000046">
        <property type="protein sequence ID" value="MZL34619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000010">
        <property type="protein sequence ID" value="MZS88815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055054157.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000048_gene1283"/>
    <dbReference type="EnsemblBacteria" id="CUO42753">
        <property type="protein sequence ID" value="CUO42753"/>
        <property type="gene ID" value="ERS852478_02778"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP61671">
        <property type="protein sequence ID" value="CUP61671"/>
        <property type="gene ID" value="ERS852523_02213"/>
    </dbReference>
    <dbReference type="GeneID" id="66494831"/>
    <dbReference type="eggNOG" id="COG1310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO42753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP61671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL34619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS88815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX63716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="143" mass="16599" checksum="11FFB493875AA56D" modified="2016-09-07" version="1">MAIIRMRDHLYDEIVNYAKEHLPEEACGLLAGVETGEGREIRKVYFLENKDHAEDHFTLDPRDQINAIRDMRANGLKPLGNWHSHPSSPSRPSVEDIRLAFDSKASYLILSLMADYPVLNSFHIEGGEWTKEDLRIYSEEYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F2T4</accession>
    <name>A0A174F2T4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inner membrane protein ypdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ypdA_4</name>
        <name evidence="6" type="ORF">ERS852478_02792</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200926.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43116">
        <property type="protein sequence ID" value="CUO43116"/>
        <property type="gene ID" value="ERS852478_02792"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021283" evidence="4">
        <location>
            <begin position="41"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="315"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO43116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="610" mass="69166" checksum="276B522DEF9DBF25" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F404</accession>
    <name>A0A174F404_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_02806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000020">
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        <property type="gene ID" value="ERS852478_02806"/>
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        <source>
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    <sequence length="547" mass="63144" checksum="8077AC72118BB7D5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F7M7</accession>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
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    </reference>
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        </source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO45216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="589" mass="64383" checksum="8F31C24A310527DE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FDQ5</accession>
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        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Predicted transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_03415</name>
        <name evidence="2" type="ORF">ERS852478_02897</name>
        <name evidence="3" type="ORF">GT712_18005</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000055">
        <property type="protein sequence ID" value="MZS90890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705144.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46470">
        <property type="protein sequence ID" value="CUO46470"/>
        <property type="gene ID" value="ERS852478_02897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13443">
        <property type="entry name" value="HTH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO46470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX67138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="72" mass="8080" checksum="716B2BEF9EAA21E4" modified="2016-09-07" version="1">MAVSYKKLWKLLIDRDMKKKDLCEAAGISHASVAKLGKNENVTTDVLVKICTALKCDISDIMEIIEIEREKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FDT2</accession>
    <name>A0A174FDT2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Daunorubicin/doxorubicin resistance ATP-binding protein DrrA</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">drrA_2</name>
        <name evidence="6" type="synonym">drrA_1</name>
        <name evidence="9" type="synonym">drrA_3</name>
        <name evidence="9" type="ORF">BWLFYP14_03606</name>
        <name evidence="5" type="ORF">ERS852478_02944</name>
        <name evidence="6" type="ORF">ERS852523_01507</name>
        <name evidence="8" type="ORF">GT712_01905</name>
        <name evidence="7" type="ORF">GT728_07260</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO47921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP40316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000013">
        <property type="protein sequence ID" value="MZL33003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706310.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000028_gene219"/>
    <dbReference type="EnsemblBacteria" id="CUO47921">
        <property type="protein sequence ID" value="CUO47921"/>
        <property type="gene ID" value="ERS852478_02944"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP40316">
        <property type="protein sequence ID" value="CUP40316"/>
        <property type="gene ID" value="ERS852523_01507"/>
    </dbReference>
    <dbReference type="GeneID" id="66493645"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO47921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP40316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS87878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX67331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="280" mass="32211" checksum="E5AEC01B4D6780E4" modified="2016-09-07" version="1">MIETRDLTKTFDNFTAVDSLNLKIEKGEFFGLLGPNGAGKTTTISLLSTLLLPTKGEILIDGQQLTRQRPDLKRKISVITQEYSMRQDMNMDEIMEYQGRLYFMPRKQIKERTEELLEFCDLLKFRKRTVRKLSGGMKRKLMVCRALLTDPEILLLDEPTAGMDALSRRQMWNLLRKLNEKNLTILLTTHYMEEAQSLCNRVALMDHGKLEEVSTPSALIESLGAYAVDEMTADGTQNHYFHTRQEAIRYLEELTGQASLRETTLEDVFVERAGKHLISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FE36</accession>
    <name>A0A174FE36_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_03418</name>
        <name evidence="2" type="ORF">ERS852478_02894</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705139.1">
        <property type="nucleotide sequence ID" value="NZ_WWVG01000064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46405">
        <property type="protein sequence ID" value="CUO46405"/>
        <property type="gene ID" value="ERS852478_02894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="606"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO46405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX67141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="704" mass="83747" checksum="4C46CBE41F13D0D0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FIS5</accession>
    <name>A0A174FIS5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48838">
        <property type="protein sequence ID" value="CUO48838"/>
        <property type="gene ID" value="ERS852478_02974"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033RVF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021710" evidence="2">
        <location>
            <begin position="43"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO48838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="170" mass="17583" checksum="14D213A59DD77C14" modified="2016-09-07" version="1">MDRQNAFREQEMNMGIKVKKILTGTALIMSLCMFTACGNANKAADEADTNEENMTDNNAANDDNMENNAGENNANGNSTSGNNAADKNVNNGGTVTDNGTAAEDEAAENETKQNSNATDNTADNTRIDENNNGDGTVSGELGNSVKDLGEGVGNAVEDVGDAVGNAAEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FJY7</accession>
    <name>A0A174FJY7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">phoR_7</name>
        <name evidence="8" type="ORF">ERS852478_02999</name>
        <name evidence="10" type="ORF">GT712_01375</name>
        <name evidence="9" type="ORF">GT728_10060</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">BIOML-A1</strain>
            <strain evidence="10 12">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO49827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000021">
        <property type="protein sequence ID" value="MZL33532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49827">
        <property type="protein sequence ID" value="CUO49827"/>
        <property type="gene ID" value="ERS852478_02999"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031967">
        <property type="entry name" value="PhoR_single_Cache-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="sCache_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="329"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO49827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS87774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="546" mass="61518" checksum="230915C58C795140" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FSX6</accession>
    <name>A0A174FSX6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO52811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201129.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52811">
        <property type="protein sequence ID" value="CUO52811"/>
        <property type="gene ID" value="ERS852478_03085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021956" evidence="1">
        <location>
            <begin position="26"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO52811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="171" mass="20136" checksum="2B873EF1EF9A266D" modified="2016-09-07" version="1">MKKIICMFLTLLLLVCIVGCNQTQDSDNHVVQDYSEEYEVSPYGSEEALDTLDDLKISMSAEKDLDLKNLSFLIENTSDKEYRYSPNYFEIETEQSGTWYQLEQLDDPSKSNEKDCFIKPNERLTLEIDVKSFYGELPAGHYRLIKQFAFFESERDWDYDTYNLSCEFTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FZA8</accession>
    <name>A0A174FZA8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">Int-Tn_7</name>
        <name evidence="9" type="ORF">ERS852478_03125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53949">
        <property type="protein sequence ID" value="CUO53949"/>
        <property type="gene ID" value="ERS852478_03125"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:integrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075713">
        <property type="term" value="P:establishment of integrated proviral latency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044826">
        <property type="term" value="P:viral genome integration into host DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004191">
        <property type="entry name" value="Integrase_Tn916-type_DNA-bd_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02920">
        <property type="entry name" value="Integrase_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="SSF54171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0229">DNA integration</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1179">Viral genome integration</keyword>
    <keyword evidence="4" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="8">
        <location>
            <begin position="82"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="7">
        <location>
            <begin position="187"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO53949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="399" mass="46991" checksum="1E5D1CE9D311A75A" modified="2016-09-07" version="1">MSEKRRDNRNRILREGEYQRKDGRYRFRYIDEDGKEKNVYSWRLDKNDPMPKGKKREPSLREKEKQIEADLFDRIVTNGGNYTVLELVEKYVSLKTGVRHNTVAGYKTVINMLKKESFGNLRIDKVRLSDAKAWLIKLQQIDGRGYSSIHSIRGVLRPAFQMAVDDDLLRKNPFEFELASVIVNDSVTREAITRKQQRDLLKFIQEDKHFSRYYDAIYILFHTGLRISEFCGLTISEIEFGEMRIKVDHQLQRTAQMQYVIEEPKTDKGIRYVPMMEAVAACFRRIIANRKTPKVEPMVEGYAGFLFLDKNDMPMVALHWEKYMEHIIQKYNRIYRIQMPKVTPHVCRHTFCSNMAKSGMNPKTLQYIMGHADISVTLNTYTHVNFDDAKEEVYRIANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G107</accession>
    <name>A0A174G107_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA strand transferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">MobA/MobL family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mobA_4</name>
        <name evidence="5" type="ORF">ERS852478_03129</name>
        <name evidence="6" type="ORF">GT712_02010</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MobA/MobL family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO54045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201182.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54045">
        <property type="protein sequence ID" value="CUO54045"/>
        <property type="gene ID" value="ERS852478_03129"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005053">
        <property type="entry name" value="MobA_MobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03389">
        <property type="entry name" value="MobA_MobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0184">Conjugation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MobA_MobL" evidence="4">
        <location>
            <begin position="17"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="479"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO54045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS87896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="526" mass="61200" checksum="792A1607A0C1A831" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GGW5</accession>
    <name>A0A174GGW5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_00757</name>
        <name evidence="1" type="ORF">ERS852478_03308</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000019">
        <property type="protein sequence ID" value="VUX63008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60119">
        <property type="protein sequence ID" value="CUO60119"/>
        <property type="gene ID" value="ERS852478_03308"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO60119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX63008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="80" mass="8817" checksum="462E552CC6F9F109" modified="2016-09-07" version="1">MGCRTEKFGAAALLFTFLIETTNGQILKNVPKTVFCVWVIKTNLKYIDISGGSWYDKNRNKSAISRKGDGYGIGTGNKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GMM9</accession>
    <name>A0A174GMM9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ethanolamine utilization protein EutJ</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Rod shape-determining protein MreB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB_3</name>
        <name evidence="3" type="synonym">eutJ</name>
        <name evidence="5" type="synonym">mreB_1</name>
        <name evidence="5" type="ORF">BWLFYP14_01444</name>
        <name evidence="2" type="ORF">ERS852478_03370</name>
        <name evidence="4" type="ORF">GT712_18830</name>
        <name evidence="3" type="ORF">GT728_19050</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO62160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000079">
        <property type="protein sequence ID" value="MZL35213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000064">
        <property type="protein sequence ID" value="MZS91036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000033">
        <property type="protein sequence ID" value="VUX64590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994052.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000079.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62160">
        <property type="protein sequence ID" value="CUO62160"/>
        <property type="gene ID" value="ERS852478_03370"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013366">
        <property type="entry name" value="EutJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02529">
        <property type="entry name" value="EutJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="1">
        <location>
            <begin position="28"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO62160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL35213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS91036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="278" mass="29686" checksum="2FEE2471D2548684" modified="2016-09-07" version="1">MELKNRTLSNFADLVQTGECKKFKGRLKVGVDLGTANTVLAVVDTTNRPIAGISAPSQAIRDGVIVNYYESVQLVTRLKAELEEKLKTELPYAAAAIPPGVSEGSSKSIQYVLEGAGFEVSNIVDEPTAAAAVLKISDGAVVDVGGGTTGISILKNGKVIYTDDEATGGSHMTMTVAGHYNIPYEEAEILKTDRSKEAEIFPVIKATVEKMATITQKFLTGYQVPAVYVVGGSASFEDFTGVFEKKLGLPVYRPVHPLLVTPLGIAYHCDLPPVTHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GV73</accession>
    <name>A0A174GV73_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">bioA</name>
        <name evidence="6" type="ORF">ERS852478_03460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201412.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65127">
        <property type="protein sequence ID" value="CUO65127"/>
        <property type="gene ID" value="ERS852478_03460"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="281"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO65127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="396" mass="45492" checksum="B320C1B1BE164829" modified="2016-09-07" version="1">MIWYPYEQMKTMKAPYKILDAEGVHLYTKDQKLIDSISSWWCMIHGYKHPELTEAIKEQADRFCHVMLGGLTHEPVEKLSAKLQEFLPGDLDYCFFSDSGSVAVEVSLKMALQYNTNQGRKRPLVLALEHAYHGDTFKAMEVGDDEDYHFAFDKKEGVVHIPTEIPALEEAFEQYHDRLNCFIVEPLLQGAGGMRMYDISFLKRARELCDQYDVLLIFDEVATGFGRTGNRFVADLVLPDILVLGKALTGGYIGHAVTVANHKVFDAFYSDDDRLALMHGPTFMGNPLACAVALKGIEIFKREDYMSKIRHIEQVSRGEMEAFTDPRIKEVRIMGGCVCVEVHDSRDLEGFQQFAYERGVFSRPFLNYMYSMVPYVISDEELIKIFDVMKEWFREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZP8</accession>
    <name>A0A174GZP8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66637">
        <property type="protein sequence ID" value="CUO66637"/>
        <property type="gene ID" value="ERS852478_03509"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO66637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="50" mass="5987" checksum="4A2A285D5CFC8967" modified="2016-09-07" version="1">MHKKTREIVLEKLRSKLIEYLKLIVWPNSVVEDGRKIKIMALDVDFMETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H6D7</accession>
    <name>A0A174H6D7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC-type transporter ATP-binding protein EcsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ecsA_4</name>
        <name evidence="5" type="ORF">ERS852478_03584</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO68946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201451.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68946">
        <property type="protein sequence ID" value="CUO68946"/>
        <property type="gene ID" value="ERS852478_03584"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO68946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="286" mass="32070" checksum="271AE11CEAB4F3D2" modified="2016-09-07" version="1">MTNYLEVTNLSKSFDSFQLHNISFTLPKGYIMGLIGPNGSGKTTTIKLILNMLKRTGGTVKVMGLDNIAEEQKVKSELGVVFDTNYFSDDWKVSQVEKSISVFYPNWDSQKFADMLRKFHIAPTKKVKELSKGMQMKLMLACAFSYDAKLLILDEPTSGLDPVSRDELLKILSEYIEDGEHSVLFSTHITGDLERAADYITYISYGELFFTGSKDDFVDMFRIVKGGIEELSDDLKNKAAGIRTFPTGFEALMKTEDISGFPNLTVDPATIDEIVVFTSKKGDDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HD17</accession>
    <name>A0A174HD17_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379848.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71236">
        <property type="protein sequence ID" value="CUO71236"/>
        <property type="gene ID" value="ERS852478_03660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12844">
        <property type="entry name" value="HTH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="184" mass="20628" checksum="80684A55ED50A218" modified="2016-09-07" version="1">MTIGERIKKIRVFRKMTMDDLGGALGFEGKNMSVRISQYETGARIPGEDMILKLADALHCNYKAISDYSLGAAEDIIETLFWLEESAASLPARGKGTRFPEYTAPGNLIHLTAMTPAKPSETARPTYNEDDYDCAGAPVALTFEYGLVNDFLSEWCEMKTKLNNGEISPNEYFEWKITWPHAMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HD32</accession>
    <name>A0A174HD32_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381437.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70929">
        <property type="protein sequence ID" value="CUO70929"/>
        <property type="gene ID" value="ERS852478_03653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="405"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO70929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1115" mass="130736" checksum="F2575E5A4225D5A6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HKQ8</accession>
    <name>A0A174HKQ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Low specificity L-threonine aldolase</fullName>
            <ecNumber evidence="4">4.1.2.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ltaE</name>
        <name evidence="4" type="ORF">ERS852478_03762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.1.2.48" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000047">
        <property type="protein sequence ID" value="CUO74036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201514.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74036">
        <property type="protein sequence ID" value="CUO74036"/>
        <property type="gene ID" value="ERS852478_03762"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO74036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="351" mass="38991" checksum="8800D1FB526EFA3B" modified="2016-09-07" version="1">MENTESRLYFASDYMEGAHPAIMKKLMETNLEKTVGYGQDPYTEDAKEKIRKACNAPEADVFLLVGGTQTNATVIDALLKSYQGVVAADTGHIATHESGAIEFGGHKVLTVPQKDGKISAQQIEKLVKDFYDDANYEHMVMPGMVYISQPTEYGTLYSREELAALSKVCRENHLPLYVDGARLAYALASPENDVTLTDLAELSDVFYIGGTKCGALFGEAVVIPQKGRIPHFFTIIKQHGALLAKGRIAGIQFGELFTDGLYLRIGKPAMEAADQIKDALKKYGYQLSLDTPTNQIFCIVSNEVMKKIAQDVEFGFWEKYDETHSVIRFATSWATTMEDTQKLIQILEKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HS00</accession>
    <name>A0A174HS00_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable cysteine desulfurase</fullName>
            <ecNumber evidence="5 6">2.8.1.7</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Putative cysteine desulfurase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">csd</name>
        <name evidence="6" type="ORF">BWLFYP14_03610</name>
        <name evidence="5" type="ORF">ERS852478_03823</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="5 6"/>
    <dbReference type="EMBL" id="CYZN01000054">
        <property type="protein sequence ID" value="CUO76117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706318.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76117">
        <property type="protein sequence ID" value="CUO76117"/>
        <property type="gene ID" value="ERS852478_03823"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010969">
        <property type="entry name" value="Cys_dSase-rel_unknwn_funct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01977">
        <property type="entry name" value="am_tr_V_EF2568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="4"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO76117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX67335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="387" mass="42168" checksum="14E33DFB545B093D" modified="2016-09-07" version="1">MNKIYLDQASTSFPKAPSVAQAVYDYLAGSAVNVNRGGYRAAYSVEEQIFETREQLLKLFHFTSGKGKNVIFTENITASLNVLLKGLLKPGDHVLVTAMEHNAVMRPLVQLEKHGISFDRIPCASDGSLLLDKATALLRPETKLVVCLHASNVCGTVMPAQEIGDFCKEHGLLFILDTAQTAGTINIDMEKCHIDALAFTGHKGLRGPQGTGGFLIRNKLAAQIEPLISGGTGSASHSEEVPAFLPDRFEPGTPNIPGILGLHAALCDLEKQSMEEIRQHELMLTQYFIDGILNLDPEEKFLRIIGKKNIENRCAVVSVQTLHMDMAQAAFELDSTYGIMTRVGLHCAPNAHKTLGTYPEGTLRFSFGPENTKQELDIALDALSALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L0B3</accession>
    <name>A0A174L0B3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metalloregulator ArsR/SmtB family transcription factor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Transcriptional repressor smtB homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ziaR_1</name>
        <name evidence="2" type="synonym">ziaR</name>
        <name evidence="2" type="ORF">ERS852478_00071</name>
        <name evidence="3" type="ORF">ERS852523_00696</name>
        <name evidence="5" type="ORF">GT712_07550</name>
        <name evidence="4" type="ORF">GT728_03085</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A1</strain>
            <strain evidence="5 8">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP14989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000005">
        <property type="protein sequence ID" value="MZL32204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703071.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1434"/>
    <dbReference type="EnsemblBacteria" id="CUN42865">
        <property type="protein sequence ID" value="CUN42865"/>
        <property type="gene ID" value="ERS852478_00071"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP14989">
        <property type="protein sequence ID" value="CUP14989"/>
        <property type="gene ID" value="ERS852523_00696"/>
    </dbReference>
    <dbReference type="GeneID" id="66492861"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018334">
        <property type="entry name" value="ArsR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00846">
        <property type="entry name" value="HTH_ARSR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN42865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP14989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="120" mass="13939" checksum="07B9F8354F08CB30" modified="2016-09-07" version="1">MEVCKEELCESNEIHEDLLKIVDETLPEETELYDLAELFKVFGDSTRIRILFVLFEAEVCVCDLAKALNMTQSAISHQLRILKQNKLVKSRREGKSIFYSLADDHVRTIINQGREHIEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NH62</accession>
    <name>A0A174NH62_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hpt domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02095</name>
        <name evidence="3" type="ORF">ERS852523_01756</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000015">
        <property type="protein sequence ID" value="CUP48042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708253.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000088_gene4040"/>
    <dbReference type="EnsemblBacteria" id="CUO19380">
        <property type="protein sequence ID" value="CUO19380"/>
        <property type="gene ID" value="ERS852478_02095"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP48042">
        <property type="protein sequence ID" value="CUP48042"/>
        <property type="gene ID" value="ERS852523_01756"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="1">
        <location>
            <begin position="40"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO19380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP48042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="116" mass="13220" checksum="2F6F0AEE46D37C64" modified="2016-09-07" version="1">MTVKECYEQMGADYEGVLGRLRSEVLIKKFAKKFLDDGSFRSLKDNLAQKNGEEAFRAAHTLKGVCQNLGFDNLYKASFDITEKLRGRDTEGCEELLAKVEEQYNNTVDAIHMMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NLU1</accession>
    <name>A0A174NLU1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-IPM isomerase</fullName>
            <shortName evidence="6">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dmdA_2</name>
        <name evidence="8" type="synonym">dmdA_1</name>
        <name evidence="6" type="synonym">leuC</name>
        <name evidence="11" type="ORF">BWLFYP14_02804</name>
        <name evidence="8" type="ORF">ERS852478_02102</name>
        <name evidence="9" type="ORF">ERS852523_01749</name>
        <name evidence="10" type="ORF">GT728_16285</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">2789STDY5834863</strain>
            <strain evidence="9 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000015">
        <property type="protein sequence ID" value="CUP47857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000049">
        <property type="protein sequence ID" value="MZL34708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708262.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000130_gene184"/>
    <dbReference type="EnsemblBacteria" id="CUO19616">
        <property type="protein sequence ID" value="CUO19616"/>
        <property type="gene ID" value="ERS852478_02102"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP47857">
        <property type="protein sequence ID" value="CUP47857"/>
        <property type="gene ID" value="ERS852523_01749"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01027">
        <property type="entry name" value="LeuC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011826">
        <property type="entry name" value="HAcnase/IPMdehydase_lsu_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006251">
        <property type="entry name" value="Homoacnase/IPMdehydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01343">
        <property type="entry name" value="hacA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02086">
        <property type="entry name" value="IPMI_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="5 6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO19616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP47857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL34708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX66430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="416" mass="44644" checksum="C6C6A1813EF850E3" modified="2016-09-07" version="1">MGMTIAEKIIAAAAGVDSVKPGDIHTVKLDRLMSNDGTTHLTVDMYNNKLKNPHIADTSKLVFIVDHNVPSDSPKTAASQKKMRDFAKEHNIDFWEGKGVCHQVMIENYVRPGELIFGADSHTCSYGALGAFGTGVGCTDFLYGMVTGTSWVLVPESVKFNLTGKLPEGVYARDLILTIIGEIGANGCNYQAMEFTGEGAKTLSISDRMALCNMAVEAGAKTGIFEADEKAIEYLKEHGREPKAVYHSDPDAVYAREYTFDLSKVRPVVAKPDFVDNVVPAEEACGIEINEAFLGSCNNGRIEDLRVGAEIIKGKKVAEGVRFLVVPASQTIYRQALKEGLIDTFMEAGAIVMNPNCSVCWGSCQGVIGENEVLISTGTRNFKGRAGHPSSKVYLGSAATVTASAITGKIALASEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NSQ4</accession>
    <name>A0A174NSQ4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">modB</name>
        <name evidence="10" type="ORF">ERS852478_00647</name>
        <name evidence="11" type="ORF">ERS852523_01775</name>
        <name evidence="12" type="ORF">GT712_08675</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">2789STDY5834863</strain>
            <strain evidence="11 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN62244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000016">
        <property type="protein sequence ID" value="CUP48919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000014">
        <property type="protein sequence ID" value="MZS89144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380219.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000063_gene710"/>
    <dbReference type="EnsemblBacteria" id="CUN62244">
        <property type="protein sequence ID" value="CUN62244"/>
        <property type="gene ID" value="ERS852478_00647"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP48919">
        <property type="protein sequence ID" value="CUP48919"/>
        <property type="gene ID" value="ERS852523_01775"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="13"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN62244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP48919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS89144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="231" mass="24876" checksum="9E7C3A8DB26D8B65" modified="2016-09-07" version="1">MSEFLAEINWSPLWISLKTGFAATVIAFFLGIFFARLVMKMKPVSRGILDGILTMPLVLPPTVAGFILLLLFSLRRPFGAFLLDNFDIKIVQTWKGCVIAASVIAFPLMYRNARAAFEQVDVNLIAAGKTLGMSDRRIFWTVVMPTAGPGIASGTVLAFARAIGEYGATSMLAGNILGKTRTVSVAIASETAAGNYGMAGFWVVVILIISFVIVAAINIVSGKGMKMGRWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174Q728</accession>
    <name>A0A174Q728_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">OMP decarboxylase</fullName>
            <shortName evidence="4">OMPDCase</shortName>
            <shortName evidence="4">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">pyrF</name>
        <name evidence="10" type="ORF">BWLFYP14_01488</name>
        <name evidence="6" type="ORF">ERS852478_02235</name>
        <name evidence="7" type="ORF">ERS852523_02420</name>
        <name evidence="9" type="ORF">GT712_11670</name>
        <name evidence="8" type="ORF">GT728_09325</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000025">
        <property type="protein sequence ID" value="CUP67701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000018">
        <property type="protein sequence ID" value="MZL33393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000022">
        <property type="protein sequence ID" value="MZS89713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705494.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000042_gene3021"/>
    <dbReference type="EnsemblBacteria" id="CUO24275">
        <property type="protein sequence ID" value="CUO24275"/>
        <property type="gene ID" value="ERS852478_02235"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP67701">
        <property type="protein sequence ID" value="CUP67701"/>
        <property type="gene ID" value="ERS852523_02420"/>
    </dbReference>
    <dbReference type="GeneID" id="66493784"/>
    <dbReference type="eggNOG" id="COG0284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="5">
        <location>
            <begin position="15"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO24275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP67701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL33393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX64635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="308" mass="33606" checksum="9E9B10C7FF763E24" modified="2016-09-07" version="1">MINKLIENIKKTNAPIVVGLDPMLNYIPQHIQKKAFSELGETLEGAAEAIWQYNKGIVDAISDLIPAVKPQIAMYEQFGIPGLMAYKNTIDYCKEKGLVVIGDIKRGDIGSTSAAYAVGHLGKVQVGSNRIAGFDEDFATINPYMGSDSVNPFIDVCKEENKGLFVLVKTSNPSSGEFQDRIIDGRPLYEWVGEKVAQWGESHMGNEYSYVGAVVGATYPEMGKTLRKIMPKTFILVPGYGAQGGKGADLVHFFNEDGLGAIVNSSRGIIAAYKQEKYASFGELNYADASRQAVKDMIEDISTALNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QQP1</accession>
    <name>A0A174QQP1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1284 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF1284)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03761</name>
        <name evidence="2" type="ORF">ERS852523_02656</name>
        <name evidence="3" type="ORF">GT728_16605</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000047">
        <property type="protein sequence ID" value="CUO74011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000029">
        <property type="protein sequence ID" value="CUP74271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000052">
        <property type="protein sequence ID" value="MZL34768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055152229.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000052.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000107_gene615"/>
    <dbReference type="EnsemblBacteria" id="CUO74011">
        <property type="protein sequence ID" value="CUO74011"/>
        <property type="gene ID" value="ERS852478_03761"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP74271">
        <property type="protein sequence ID" value="CUP74271"/>
        <property type="gene ID" value="ERS852523_02656"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009702">
        <property type="entry name" value="DUF1284"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06935">
        <property type="entry name" value="DUF1284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO74011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP74271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="133" mass="14982" checksum="EA7058BB00DA768A" modified="2016-09-07" version="1">MSFIKNIPLRPHHGMCLAYFKGEGYSDGFSAHMQEMLDIFQKGAKIQLHADTDEICSACPNNEKGCCSSFSLVEAYDNAVLELCGLENGQIMEFDDFTDVVQKKILASGKRKEICGNCQWNSICESQKSRWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174RT00</accession>
    <name>A0A174RT00_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00546</name>
        <name evidence="2" type="ORF">ERS852523_03071</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000038">
        <property type="protein sequence ID" value="CUP86110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58860">
        <property type="protein sequence ID" value="CUN58860"/>
        <property type="gene ID" value="ERS852478_00546"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP86110">
        <property type="protein sequence ID" value="CUP86110"/>
        <property type="gene ID" value="ERS852523_03071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN58860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP86110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="58" mass="6714" checksum="DCE524B0FD803BD0" modified="2016-09-07" version="1">MTKKWFLLKVLYIFIVFWGSVTCNEKTVLANEYTIVDENAGYNFLGFCYTVSGEELFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174TB10</accession>
    <name>A0A174TB10_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="6">Glu-ADT subunit A</shortName>
            <ecNumber evidence="6">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">gatA</name>
        <name evidence="11" type="ORF">BWLFYP14_00736</name>
        <name evidence="8" type="ORF">ERS852478_03330</name>
        <name evidence="9" type="ORF">ERS852523_03774</name>
        <name evidence="10" type="ORF">GT728_14560</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">2789STDY5834863</strain>
            <strain evidence="9 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000064">
        <property type="protein sequence ID" value="CUQ05297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000039">
        <property type="protein sequence ID" value="MZL34385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000019">
        <property type="protein sequence ID" value="VUX62987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704899.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000041_gene2599"/>
    <dbReference type="EnsemblBacteria" id="CUO60891">
        <property type="protein sequence ID" value="CUO60891"/>
        <property type="gene ID" value="ERS852478_03330"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ05297">
        <property type="protein sequence ID" value="CUQ05297"/>
        <property type="gene ID" value="ERS852523_03774"/>
    </dbReference>
    <dbReference type="GeneID" id="66494378"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="26"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO60891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUQ05297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL34385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX62987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="489" mass="53083" checksum="C3E8ED4838D448DE" modified="2016-09-07" version="1">MELEKLTALQLGEKIKQRQVSVLDGVKTVFEQIEKQDSEVHAYLDTYKEEAYKRAEEVQKGIEDGTYTSPLAGVPIAIKDNICINGKKTTCASKILENFVPQYNAEVIDRLEKAGLVIIGKTNMDEFAMGSTTETSAYGITRNPWNLEHVPGGSSGGSCAAVAAGETYLALGSDTGGSIRQPSSYCGVTGIKPTYGTVSRYGLVAYASSLDQIGPVGKDVSDCAALLEIIAGHDTKDSTSMKREDLQFSKELTGDIKGMKFGVPEEYLAEGLDPEVKASFMGVLDTLKELGAEVEFFSIKTMEYMIPAYYIIASAEASSNLERFDGVKYGFRAAEYEGLHDMYKKTRTAGFGEEVKRRIMLGSFVLSSGYYDAYYLKALRTKALIKKEFDQAFGKYDVLLAPASPFTAPKIGESLKDPLAMYLGDIYTVAVNLCGLPGITVPCGKDSKGLPIGIQMIGDCFMEKKILRAAHAYETSRGSFAVPGEGGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WRY6</accession>
    <name>A0A173WRY6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">ATP phosphoribosyltransferase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">hisZ</name>
        <name evidence="8" type="ORF">ERS852478_00015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heteromultimer composed of HisG and HisZ subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199466.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41105">
        <property type="protein sequence ID" value="CUN41105"/>
        <property type="gene ID" value="ERS852478_00015"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00125">
        <property type="entry name" value="HisZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004517">
        <property type="entry name" value="HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00443">
        <property type="entry name" value="hisZ_biosyn_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN41105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="372" mass="42567" checksum="8FC384A6BED906B6" modified="2016-09-07" version="1">MQRIFHTPEGVRDIYNGECSQKRKVQEKIHRVFHQYGYEDIETPTFEYFEVFSREVGTIPSKELYKFFDREGNTLVLRPDFTPSVSRACATYFSPDKEPVSLCYTGNTFINNTSYRGHLKETTQMGVERIGDESADADAELLAMTVECLLAAGLTEFQVSVGQVDYFKSLLKEAELGPEAEERLRVLISQKNSFGVEEFVEEQKLKDSMQKAFTEIPQMFGSEEVLKKARSLTNNACALEAVSRLEEIYEIMKNYGYEKYISFDFGMLSKYQYYTGIIFQAYTYGTGEPMIKGGRYNGLMKHFGKPAASIGFALEVDNLLLALSSQKLISEKEEKPEVIEYEPQNRKEAIKEAQKLRAEGRCVALRLKKEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WS26</accession>
    <name>A0A173WS26_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sirohydrochlorin cobaltochelatase</fullName>
            <ecNumber evidence="3">4.99.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbiK_1</name>
        <name evidence="3" type="ORF">ERS852478_00021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.99.1.3" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199470.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41297">
        <property type="protein sequence ID" value="CUN41297"/>
        <property type="gene ID" value="ERS852478_00021"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016852">
        <property type="term" value="F:sirohydrochlorin cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019251">
        <property type="term" value="P:anaerobic cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010388">
        <property type="entry name" value="Anaerobic_Co-chelatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06180">
        <property type="entry name" value="CbiK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008014880" evidence="2">
        <location>
            <begin position="30"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN41297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="465" mass="49322" checksum="DDB30170F4A22B76" modified="2016-09-07" version="1">MKRKSMLALLLAVSMTCSMTAATGTVAFASDDAATEEAADDTEAAADDAAAADTEKASEDTTEASDDDQKAADEVGALIDKIYVQERTDTTDEDCKAAKEAWDKLTDAQKELVTGEEASPEYFGRDTGDASKDDPRNQDEIGENELLVVSFGTSFNDSRAEDIKGIEDALAKAYPDWSVRRAFTAQIIINHVQARDDEVIDNMQQALDRAVANGVKNLVVQPTHLMHGAEYDEMTEAIDGYKDKFESVAIAEPMLGEVGDDATVINDDKKAVAQAITDEACKEAGFDDMKAAADAGTAFVFMGHGTSHTANVTYDQMQTQMDNLGFTNAFVGTVEGKPEDTACDKVIEKVKEAGFKNVILRPLMVVAGDHANNDMAGDDADSWKSQFEASGDFDSVDCQIAGLGRIAAVEDLYVAHTKAAIDSLGASDDAAAEDTNAEAAGDSADDAQADDAAETTADTAQADAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WWC7</accession>
    <name>A0A173WWC7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybeB</name>
        <name evidence="2 5" type="synonym">rsfS</name>
        <name evidence="7" type="ORF">BWLFYP14_02602</name>
        <name evidence="3" type="ORF">ERS852478_00104</name>
        <name evidence="4" type="ORF">ERS852523_01886</name>
        <name evidence="6" type="ORF">GT712_00945</name>
        <name evidence="5" type="ORF">GT728_02925</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP52035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000005">
        <property type="protein sequence ID" value="MZL32172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703130.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000020_gene122"/>
    <dbReference type="EnsemblBacteria" id="CUN43822">
        <property type="protein sequence ID" value="CUN43822"/>
        <property type="gene ID" value="ERS852478_00104"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP52035">
        <property type="protein sequence ID" value="CUP52035"/>
        <property type="gene ID" value="ERS852523_01886"/>
    </dbReference>
    <dbReference type="GeneID" id="66495921"/>
    <dbReference type="eggNOG" id="COG0799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN43822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP52035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL32172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS87691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="119" mass="13743" checksum="993AA0071AA17B42" modified="2016-09-07" version="1">MNRELEMAKLACRALDEKKGKDIKVIDIHEVSVIADYFVIASASNQNQVQAMVDNVDETLGRAGFEAKQIEGTRNSSWVLMDYGDMIVHVFDEENRLFYDLERIWRDGKVLDVNEFLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WXI1</accession>
    <name>A0A173WXI1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tyrosine recombinase XerS</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">xerS</name>
        <name evidence="9" type="ORF">BWLFYP14_02615</name>
        <name evidence="6" type="ORF">ERS852478_00117</name>
        <name evidence="8" type="ORF">GT712_00875</name>
        <name evidence="7" type="ORF">GT728_20330</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">BIOML-A1</strain>
            <strain evidence="8 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000099">
        <property type="protein sequence ID" value="MZL35452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052780.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000099.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44203">
        <property type="protein sequence ID" value="CUN44203"/>
        <property type="gene ID" value="ERS852478_00117"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="33"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="157"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN44203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL35452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS87678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="360" mass="41748" checksum="573F1B052C155843" modified="2016-09-07" version="1">MDKYIDYYNDSKKVTYHEQTDISNILKLRAVLKTLPDFCKDYFRAMDPLTTTKTRISYAYDIRIFFQFLLDENPAFKDYSMKDFTVDVLDQLKAIDIEEYQEYLKVYKNGDKTETNGERGLKRKISALRSFYAYYYKHEFIQTNPTVLVDVPKTHEKNIIRLDADEVAMLLDHIEHCGDELTGQKRVYYEKTKERDLAIVTLLLGTGIRVSECVGLDVEDVDFKNNGIKVTRKGGNEMVVYFGHEVEKALKKYLEVRKNIVPVAGHEHALFYSTQRKRIGIQAVENLVKKYAGAITTTKKITPHKLRSTYGTTLYQETGDIYLVADVLGHRDVNTTKKHYAAMDDARRRKAATAVHLRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WXR1</accession>
    <name>A0A173WXR1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative acyl-CoA thioester hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Uncharacterized acyl-CoA thioester hydrolase HI_0827</fullName>
            <ecNumber evidence="5 6">3.1.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_02586</name>
        <name evidence="5" type="ORF">ERS852478_00087</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.-" evidence="5 6"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43337">
        <property type="protein sequence ID" value="CUN43337"/>
        <property type="gene ID" value="ERS852478_00087"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="4">
        <location>
            <begin position="29"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN43337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="178" mass="20195" checksum="DCE9987241B9A516" modified="2016-09-07" version="1">MERAIIANRKHDKGEVRKEMSERKMKRVEDSLTEQSHLLMPKCLNAAGYLFGGQLLAWIDETAGIVAKRHAEMNVVTVAVDNMYFKAGARVNDTIVLIGRLTHVGRSSMEVRIDTYCEALDGTRTMINRAYFIMVGTDEHQHPVEVPGLIIEGVTQQIENEAAQKRAKLWKVRRQEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WZP9</accession>
    <name>A0A173WZP9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF2442)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703159.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000198.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44366">
        <property type="protein sequence ID" value="CUN44366"/>
        <property type="gene ID" value="ERS852478_00123"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032VN8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018841">
        <property type="entry name" value="DUF2442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036782">
        <property type="entry name" value="NE0471-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10387">
        <property type="entry name" value="DUF2442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143880">
        <property type="entry name" value="SSF143880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN44366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="94" mass="10741" checksum="EE23F74BADA730B5" modified="2016-09-07" version="1">MNEYFPTVVQVIPLDNFHVQVFFDDGKIVDYDATEDLKTEIFKPLRDIDAFKEACTVMNGTLAWDLSGNRDESSCIDIDPFTVYELESINNLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X0W4</accession>
    <name>A0A173X0W4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0291 protein BWLFYP14_02661</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_02661</name>
        <name evidence="2" type="ORF">ERS852478_00163</name>
        <name evidence="3" type="ORF">ERS852523_00320</name>
        <name evidence="5" type="ORF">GT712_00640</name>
        <name evidence="4" type="ORF">GT728_06175</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0291 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000003">
        <property type="protein sequence ID" value="CUP03543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703220.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000032_gene394"/>
    <dbReference type="EnsemblBacteria" id="CUN45363">
        <property type="protein sequence ID" value="CUN45363"/>
        <property type="gene ID" value="ERS852478_00163"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03543">
        <property type="protein sequence ID" value="CUP03543"/>
        <property type="gene ID" value="ERS852523_00320"/>
    </dbReference>
    <dbReference type="GeneID" id="66495860"/>
    <dbReference type="eggNOG" id="COG4224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01103">
        <property type="entry name" value="UPF0291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009242">
        <property type="entry name" value="DUF896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37300">
        <property type="entry name" value="PTHR37300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05979">
        <property type="entry name" value="DUF896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN45363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP03543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS87633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="73" mass="8491" checksum="DDDA80FC56141CE1" modified="2016-09-07" version="1">MEVEKIDRINALAHKAKSVGLTEEEKKERELLRKEYIASVRMNLRAQLDNVDVQQEDGTIINLGEKYGIKKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X0X0</accession>
    <name>A0A173X0X0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate 5-kinase</fullName>
            <ecNumber evidence="7">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-glutamyl kinase</fullName>
            <shortName evidence="7">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">proB</name>
        <name evidence="10" type="ORF">BWLFYP14_02662</name>
        <name evidence="9" type="ORF">ERS852478_00164</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052766.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45391">
        <property type="protein sequence ID" value="CUN45391"/>
        <property type="gene ID" value="ERS852478_00164"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="223"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN45391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX66290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="285" mass="31145" checksum="F630AD4807CF4928" modified="2016-09-07" version="1">MNYRERLKDKKRIVIKIGSSSLTHSETGRLNLRKLEVLARELSDLRNQGKDVILVSSGAIATGVAALGMHEKPTELKGKQACAAVGQARLMMIYQKLFSEYNQLSAQILMTKNTMVNNVNRKNAQNTFDELLSLGVIPIVNENDSISTYELQNLEKFGDNDTLSAMVAALVRADLLILLSDIDGLFTDDPNTNPDAKFIDVVENLDDNLLNMGKGTSGSKVGTGGMATKLTAAQIASAAGVDMVIANGADFHIIHKITEGRRYGTLFVSQSKEEVYLIDIIDRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X3Y1</accession>
    <name>A0A173X3Y1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">cobU_2</name>
        <name evidence="18" type="ORF">ERS852478_00204</name>
        <name evidence="20" type="ORF">GT712_00440</name>
        <name evidence="19" type="ORF">GT728_05975</name>
    </gene>
    <organism evidence="18 21">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="18 21" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 21">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="19 22 23" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 23">BIOML-A1</strain>
            <strain evidence="20 22">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381053.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46472">
        <property type="protein sequence ID" value="CUN46472"/>
        <property type="gene ID" value="ERS852478_00204"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043752">
        <property type="term" value="F:adenosylcobinamide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006135">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="16">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CUN46472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MZL32765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="MZS87595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="180" mass="19794" checksum="F306DEDDE6486F4C" modified="2016-09-07" version="1">MLTLVTGGSGSGKSAFAEDRVLSFGDAQRIYIATMHPFDEESHKRIERHQKMRAGKGFETVECYTGLKNVKLPAGCVVLLECMSNLVANEMFEEQGAHDRTVSEVTKGIENLLEQAAHVVIVTNEIFSDAVVFDGDMDSYLEYLGKINQAAAQRADEVVEVIYGIPVFHKSADTCSNLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XLN0</accession>
    <name>A0A173XLN0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7 9">sn-glycerol-3-phosphate transport system permease protein UgpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ugpA_1</name>
        <name evidence="9" type="synonym">ugpA</name>
        <name evidence="9" type="ORF">BWLFYP14_01991</name>
        <name evidence="7" type="ORF">ERS852478_00372</name>
        <name evidence="8" type="ORF">GT712_06035</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000009">
        <property type="protein sequence ID" value="MZS88658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199589.1">
        <property type="nucleotide sequence ID" value="NZ_JADPFJ010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52604">
        <property type="protein sequence ID" value="CUN52604"/>
        <property type="gene ID" value="ERS852478_00372"/>
    </dbReference>
    <dbReference type="GeneID" id="66496002"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="69"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN52604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS88658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX65400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="293" mass="32672" checksum="23EFCE738E2AF947" modified="2016-09-07" version="1">MVKKPRLFIALCTLPALILTIVFMIVPMVNAIYLSFTSSTALSVGFNSKFVFLDNYKYMFQDKDFLQALFNTLKLMLVIPAVTIFLSLVFAFILTQGQLKEKSFYRTVFFFPSIVSMTVVGIVWSFVFNPTRGILNHMLDLFHFSTWKHAWLGEGKTALWCIGAALVWQAIGYYMVMHVASIDGISQEVYEAASIDGATGVQKFFRITIPLLRRSIGTTYILSLSGTINLSFTLSNVMTGGGPNGASSVLLQYMYTQGMRNANFGYAMAIAMFTLILAIVLAMISKKVSSEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XXE3</accession>
    <name>A0A173XXE3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Altronate oxidoreductase</fullName>
            <ecNumber evidence="4">1.1.1.58</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">uxaB</name>
        <name evidence="4" type="ORF">ERS852478_00467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.1.1.58" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199650.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56354">
        <property type="protein sequence ID" value="CUN56354"/>
        <property type="gene ID" value="ERS852478_00467"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008926">
        <property type="term" value="F:mannitol-1-phosphate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009026">
        <property type="term" value="F:tagaturonate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol_dh" evidence="2">
        <location>
            <begin position="25"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol_dh_C" evidence="3">
        <location>
            <begin position="217"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN56354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="502" mass="57747" checksum="C051C8DFAB020D85" modified="2016-09-07" version="1">MKKLNYEVLKESGYKGYVLKDAPEKVLQFGEGNFMRAFVDYFIDMMNEKAGFNGKVVLVQPIRNVEGGFRLNDRINEQEGLYTLFLRGFQDGKKVNDKRVISSVSRCLNAYEDYEEVMKCAENPELRFILCNTTEAGIRYDAECKFEDKPGESYPAKLTQFMYHRFETFGKEEGKGFIILSCELIDDNGKELEKCVLKYAKQWNLGEEFITWIQKENVFCSTLVDRIVTGYPRNEASAICEELGYEDNVLDTGEIFGFWVIEGPQSIKKEFPIEEAGLPILITDNHKPYKQRKVRILNGAHTSFVLGAYLAGKDIVRDCMNDEVICRFMNKTIYDEIIPTLDLPKEELIDFASAVTERFKNPFIDHALLAISLNSTSKWKARVMPSLKEYVKRKGTLPKCITASFAFYIAFFSGHTLTEEGLIAEREGNTYTVKDDREVLQFYYEHREDSTEKMVHAVCKNTEFWGEDLTEIEGFESAVCGYLDQIRKEGSYSVMKSLISLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XZH5</accession>
    <name>A0A173XZH5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized ABC transporter ATP-binding protein HI_1470</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_00480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199663.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56783">
        <property type="protein sequence ID" value="CUN56783"/>
        <property type="gene ID" value="ERS852478_00480"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN56783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="265" mass="28860" checksum="882024796F8352B0" modified="2016-09-07" version="1">MLLEIENVFGGYGNGDILKGISCSADYGDVLCLLGPNGCGKTTLFRMILGSLPVSNGKIKIAGKNISDFTTKTLANMIAYIPQYHSPVFAYTVLDMVIMGRASHFSAFETPREPDQEAAFAALEKVNALSLANRKYTSLSGGQRQLVLIARAICQSAKIFIMDEPAANLDYANHQLLMEVISGLANQGYCIIMSTHSPEHPFSVGNKVLLMKSGKVMGFGSPKEIITSETLQSVYDIEMDVITTHDRYGRERTICLPVNSSAKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XZY8</accession>
    <name>A0A173XZY8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Macrolide-specific efflux protein macA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">macA</name>
        <name evidence="5" type="ORF">ERS852478_00473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199656.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56566">
        <property type="protein sequence ID" value="CUN56566"/>
        <property type="gene ID" value="ERS852478_00473"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015814" evidence="4">
        <location>
            <begin position="33"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="348"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN56566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="609" mass="65847" checksum="7DDA6D5E98002C3A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y218</accession>
    <name>A0A173Y218_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199692.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58201">
        <property type="protein sequence ID" value="CUN58201"/>
        <property type="gene ID" value="ERS852478_00522"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50348PD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN58201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="65" mass="7396" checksum="ED4A419C91E580F5" modified="2016-09-07" version="1">MAKNYESESKNSRNYTGTSDKNSYGNEMNHDGNAKNSVKSKNETDCRSKAKNKTSQSYSSEEDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y537</accession>
    <name>A0A173Y537_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein BlaR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">blaR1_1</name>
        <name evidence="3" type="ORF">ERS852478_00544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199700.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58803">
        <property type="protein sequence ID" value="CUN58803"/>
        <property type="gene ID" value="ERS852478_00544"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="2">
        <location>
            <begin position="8"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN58803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="449" mass="51354" checksum="3D881F38152BFC21" modified="2016-09-07" version="1">MKILICLLIYMSVSGSAFFLGYLLLDFLTHEMLPASFRYFLLKLGGLFFLVPFPLVKSLVQSWLFHCENGILKTDEYYFFDIDHSIKLIDEGFIFPQLPDSQKVLIGLWTGIMLLIILSQAYRFYLFRRNLRKYLLPLDNCEDLLNSIKADMNITKKVSMYYCGAEISPFTCGVKSPVIILTSLVADDSKELILRHELQHIKSHDLIYRMAALFIVLIHCFNPLSYLFLKELKEVQEMNCDEKLTVTFSNNERMKYGKAIIAVSARTGAFSAPVLYFSGNSKSFLIKRIRKISVPGRIRKLQMALATIVLCLFATVPVFAYSPEIIDLRNFSSDIQNGIEEVTWMEFEFDSSSDTGSAITIPEDENFFSDCNQYFLLEDGTVILLPDRNIQLFSGCKHSFKTGVLKKHISSGKSCTVNQYRGEICTKCNYIKNKTLVNSVYSPVCPHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YP75</accession>
    <name>A0A173YP75_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">rpe_1</name>
        <name evidence="10" type="synonym">rpe</name>
        <name evidence="15" type="ORF">ERS852478_00728</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65942">
        <property type="protein sequence ID" value="CUN65942"/>
        <property type="gene ID" value="ERS852478_00728"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0036">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="196"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUN65942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="223" mass="25152" checksum="9C81811CE9387BD5" modified="2016-09-07" version="1">MYQLCPSILSADFNRLGEQIKTLEKEGIEWLHIDVMDGDFVPSISFGMPVIKSIRKESKLFFDVHLMVTEPERYIRDFVECGADSITVHAEACEDLERTIEQIREAGVKVGVSIKPATPVNDISHMLSDVDMVLIMTVQPGFGGQKYMEECTEKIREVRELIEAEDLDVDVQVDGGINDETMETVLTAGANLLVAGSYVFKDDLAKNVKHARERMDEIIRRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YPX4</accession>
    <name>A0A173YPX4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neutral zinc metallopeptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Peptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative neutral zinc metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_01787</name>
        <name evidence="2" type="ORF">ERS852478_00734</name>
        <name evidence="3" type="ORF">GT712_03085</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706498.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66221">
        <property type="protein sequence ID" value="CUN66221"/>
        <property type="gene ID" value="ERS852478_00734"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007395">
        <property type="entry name" value="Zn_peptidase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36434">
        <property type="entry name" value="PTHR36434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04298">
        <property type="entry name" value="Zn_peptidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN66221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS88096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="231" mass="24567" checksum="5DD9E682E0586AF9" modified="2016-09-07" version="1">MYGYYYFDPTYLLLVIGMVLSLLASAKVKSTFSVYSRVRSASGLTGADAARRILRMSGITDVTVVPISGSLTDHYDPGSKKLALSQDVYDKTSVAAIGVAAHECGHAIQHATNYVPLNLRSAIVPVANIGSTLSWPLFLAGLIFSIRPLLTVGIILFTFAVLFQLVTLPVEFNASSRALKMLGSSGMLGADEVKGARKVLTAAALTYVAALASSILQLLRLIILAGGRDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YT28</accession>
    <name>A0A173YT28_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bile acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199785.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66603">
        <property type="protein sequence ID" value="CUN66603"/>
        <property type="gene ID" value="ERS852478_00745"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="PTHR10361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN66603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="316" mass="34393" checksum="FF26E6418F425068" modified="2016-09-07" version="1">MLRKFNSFIEKWMALVTPTCLLLGVCFPDIAKCGLPYVPAVFAFMTFAGALKSRFKDVANVFRHPGSLLIIMLLVHVVIPTASCGAGHLFFGNNMELITGMVLEFAVPTAVVSLMWVTIYDGNSPLSLSLVVLDTVLAPFVIPATLKILLGSAVTIDPARMMRELIFMVALPAVVAMVLNQITDGKVMETWPGKLAPFSKLALIFVVTSNSSKVAPYIRDMNMQRVKVALAILVLAASGYALGWFVAYIFRKDRSTAVSMMYGTGMRNISAGAVIAAAYFPGEVMFPVMIGTLFQQVLAALFGKLLAQKKEKQEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YUU3</accession>
    <name>A0A173YUU3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199786.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66785">
        <property type="protein sequence ID" value="CUN66785"/>
        <property type="gene ID" value="ERS852478_00750"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008407">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_AzlD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05437">
        <property type="entry name" value="AzlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN66785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="105" mass="11653" checksum="345128ACD991CF6E" modified="2016-09-07" version="1">MSHNIYIYILVMAAVTYLIRMLPLALSRKEITSPFIRSFLYYVPYACLAAMTFPAILFATDSVISAAVGFIVALIAAYKEKSLLTVALFACAAVFIMERILEFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZFU9</accession>
    <name>A0A173ZFU9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="2">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GlcN6P deaminase</fullName>
            <shortName evidence="2">GNPDA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nagB_1</name>
        <name evidence="2" type="synonym">nagB</name>
        <name evidence="4" type="ORF">ERS852478_00983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199870.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75121">
        <property type="protein sequence ID" value="CUN75121"/>
        <property type="gene ID" value="ERS852478_00983"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="3">
        <location>
            <begin position="14"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for enolization step" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for ring-opening step" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN75121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="247" mass="26999" checksum="33A98D4E9A5382DF" modified="2016-09-07" version="1">MIIYAGKDYNDVSRKAANIMSAQIIMKPDAVLGLATGSTPVGMYKQLIEWYKKGDLDFAKVTSVNLDEYKGLSGDNDQSYRYFMNTNLFDHVNIDKTKTYVPNGLEEDSEKACADYNAIIRSVGGVDMQLLGIGGNGHIGFNEPGEAFEKETHCVNLTESTIKANARFFASMDEVPKQAYTMGIKSIMSAKKILLIATGEAKADALYKSLYGPITPNVPASILQLHPDVTVVADEAALKLIREKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZKC0</accession>
    <name>A0A173ZKC0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nickel transport system permease protein nikB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nikB_2</name>
        <name evidence="7" type="ORF">ERS852478_01030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199886.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76674">
        <property type="protein sequence ID" value="CUN76674"/>
        <property type="gene ID" value="ERS852478_01030"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="99"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN76674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="312" mass="34902" checksum="911B2A09B45C8C6E" modified="2016-09-07" version="1">MTKKQIGKRFLQILIVLFGISFLTFGLTYLSPGDPAEIMLTECGNLPTPELLEQTRHELGLDQPFLVQYGTWLKGVLTGDMGQSYSFKMPVVQKLVSCFWPTLKMSLLALLMMIVISIPLGILAAVYQNKFPDYFVRGITFIGVSVPSFWLGLILLSIFGVQLRWVNVAGGSTDFKAMVLPALTLALAMSAKYTRQVRSAVLEELHQDYVTGARMRGIKERVILWRHVLPNVMLPLVTLLGLSLGSLLGGTAVVEIIYNWPGMGNMAVKAISCRDYPLVQGYVLWIAILYMCINLLVDLSYTYLDPRLKEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZSM9</accession>
    <name>A0A173ZSM9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">dnaK</name>
        <name evidence="14" type="synonym">dnaK_2</name>
        <name evidence="17" type="ORF">BWLFYP14_00343</name>
        <name evidence="13" type="ORF">ERS852478_01063</name>
        <name evidence="14" type="ORF">ERS852523_02678</name>
        <name evidence="16" type="ORF">GT712_13630</name>
        <name evidence="15" type="ORF">GT728_14300</name>
    </gene>
    <organism evidence="13 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 18">2789STDY5834863</strain>
            <strain evidence="14 19">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="15 21 22" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 22">BIOML-A1</strain>
            <strain evidence="16 21">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="17 20" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="9">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000030">
        <property type="protein sequence ID" value="CUP75065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000037">
        <property type="protein sequence ID" value="MZL34338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000028">
        <property type="protein sequence ID" value="MZS90084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707391.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000035_gene3845"/>
    <dbReference type="EnsemblBacteria" id="CUN78823">
        <property type="protein sequence ID" value="CUN78823"/>
        <property type="gene ID" value="ERS852478_01063"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP75065">
        <property type="protein sequence ID" value="CUP75065"/>
        <property type="gene ID" value="ERS852523_02678"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="588"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="9">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN78823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUP75065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL34338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZS90084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VUX67498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="625" mass="66704" checksum="BB21A22483A4F242" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AF36</accession>
    <name>A0A174AF36_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF3789)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199986.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86499">
        <property type="protein sequence ID" value="CUN86499"/>
        <property type="gene ID" value="ERS852478_01247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024522">
        <property type="entry name" value="DUF3789"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12664">
        <property type="entry name" value="DUF3789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN86499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="50" mass="5610" checksum="30DC808E07CC8327" modified="2016-09-07" version="1">MSEFLFFIIGTMLGGLFGVVCMCCLQINKLSERKEEDNAKKKCADTFPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AIA9</accession>
    <name>A0A174AIA9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bifunctional purine biosynthesis protein PurH</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purH</name>
        <name evidence="1" type="ORF">ERS852478_01303</name>
        <name evidence="2" type="ORF">ERS852523_00895</name>
        <name evidence="4" type="ORF">GT712_09425</name>
        <name evidence="3" type="ORF">GT728_08210</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
            <strain evidence="2 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">BIOML-A1</strain>
            <strain evidence="4 7">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.2.3" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000007">
        <property type="protein sequence ID" value="CUP20815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000015">
        <property type="protein sequence ID" value="MZL33182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705691.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000047_gene1269"/>
    <dbReference type="EnsemblBacteria" id="CUN88421">
        <property type="protein sequence ID" value="CUN88421"/>
        <property type="gene ID" value="ERS852478_01303"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20815">
        <property type="protein sequence ID" value="CUP20815"/>
        <property type="gene ID" value="ERS852523_00895"/>
    </dbReference>
    <dbReference type="GeneID" id="66494938"/>
    <dbReference type="eggNOG" id="COG0138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN88421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP20815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="394" mass="44090" checksum="51325DDB9F6329EA" modified="2016-09-07" version="1">MKEFELKYGCNPNQKPAKIYMADGSELPVKILSGRPGYINFLDAFNGWQLVSNLKKATGLPAATSFKHVSPAGAAVGLPLTETLAKIYWVNDMDWKNFSPLACAYARARGADRMSSFGDFISLSDVCDKDTALLIKREVSDGVIAPGYTEEALEILKQKKKGNYNVIQIDENFVPAPLEHKEVFGVTFEQGRQELEIDDAMLSNIVTENKELTEEAKRDMKISLIILKYTQSNSVCFVKDGQAIGVGAGQQSRVHCTRLAGQKADNWFLRQCPKVLNLPFKDTISRAERDNAIDVYIGDEYMDVLADGMWEKTFTEKPEVFTKEEKRAWLDQMTDVTLGSDAFFPFSDNIERAHKSGVKYIAQPGGSVRDDAVIETCNKYGMVMSFTGIRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AKU3</accession>
    <name>A0A174AKU3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Thymidylate synthase</fullName>
            <shortName evidence="4">TS</shortName>
            <shortName evidence="4">TSase</shortName>
            <ecNumber evidence="1 4">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thyA1</name>
        <name evidence="4" type="synonym">thyA</name>
        <name evidence="6" type="ORF">ERS852478_01325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="1 4"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200013.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89202">
        <property type="protein sequence ID" value="CUN89202"/>
        <property type="gene ID" value="ERS852478_01325"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="PTHR11548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="SSF55831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylat_synt" evidence="5">
        <location>
            <begin position="8"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="183"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="224"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN89202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="282" mass="32945" checksum="6DB4FEEB2D088023" modified="2016-09-07" version="1">MSYADDVFIKMCQDILENGTSTEGEKVRPVWEDGTPAYTIKKFGVVNRYDLRKEFPAMTLRRTALKSAMDEILWIWQKKSNNIHDLHSHIWDSWADENGSIGKAYGYQLGVKHQYKEGMMDQVDRVIYDLKNNPFSRRIMTNIYVHQDLHEMNLYPCAYSMTFNVTQTPENEKLTLNAILNQRSQDILTANNWNVCQYAILLMMIAQVCDMEAGELLHVVADCHIYDRHIPVVKEMIKRKPYPAPIVKLNPEVKDFYQFTTDDLIVENYETWPQIKNIPVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AQH8</accession>
    <name>A0A174AQH8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable sensor-like histidine kinase YehU</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yehU_4</name>
        <name evidence="4" type="ORF">ERS852478_01337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89726">
        <property type="protein sequence ID" value="CUN89726"/>
        <property type="gene ID" value="ERS852478_01337"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="His_kinase" evidence="3">
        <location>
            <begin position="401"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="502"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN89726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="614" mass="70058" checksum="CE0E53A9D08F8CE6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AYJ6</accession>
    <name>A0A174AYJ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN92570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200048.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN92570">
        <property type="protein sequence ID" value="CUN92570"/>
        <property type="gene ID" value="ERS852478_01389"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="162"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN92570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="529" mass="61157" checksum="DCF12FA7993644F4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BAK3</accession>
    <name>A0A174BAK3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200132.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97644">
        <property type="protein sequence ID" value="CUN97644"/>
        <property type="gene ID" value="ERS852478_01538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026989">
        <property type="entry name" value="TnpV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14198">
        <property type="entry name" value="TnpV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN97644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="108" mass="12074" checksum="379DC5D0ECF379BC" modified="2016-09-07" version="1">MRRLIDNGTTPPARLPHIGHYGHLRKSYLEGYRPDLYTALAASEKLYEHCAEIDAAARSRIDLIMPELAKSAGATEELKAADPMKWVGLMNACKAQAEEIVKYELIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BMD1</accession>
    <name>A0A174BMD1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LexA repressor</fullName>
            <ecNumber evidence="2">3.4.21.88</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lexA_2</name>
        <name evidence="2" type="ORF">ERS852478_01632</name>
        <name evidence="3" type="ORF">ERS852523_02243</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.88" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000022">
        <property type="protein sequence ID" value="CUP62488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_024720752.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01723">
        <property type="protein sequence ID" value="CUO01723"/>
        <property type="gene ID" value="ERS852478_01632"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP62488">
        <property type="protein sequence ID" value="CUP62488"/>
        <property type="gene ID" value="ERS852523_02243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="1">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO01723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP62488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="70" mass="8097" checksum="51373BF262E05F0F" modified="2016-09-07" version="1">MKKALTRKQEESYQCILRYTNEHGYPPTIREFGKLIGVKSTSSAFSRIKQLELNGYIRRIPASPRAIEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BNF9</accession>
    <name>A0A174BNF9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_024720751.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01759">
        <property type="protein sequence ID" value="CUO01759"/>
        <property type="gene ID" value="ERS852478_01633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO01759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="79" mass="9348" checksum="59892DBAEA3CCBD6" modified="2016-09-07" version="1">MNKVYVDVVAEFRKNGQLVPIFFTWEDGRKYSIDRILKIERCASRKAGGVGMMYTCMIQGQESHLFYEVDKWFMERKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BPK7</accession>
    <name>A0A174BPK7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200164.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02523">
        <property type="protein sequence ID" value="CUO02523"/>
        <property type="gene ID" value="ERS852478_01655"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO02523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="381" mass="42836" checksum="41C0254A5DFFDD68" modified="2016-09-07" version="1">MSKFLKFIVHFIVICTIVCVVGLAVPPFLGITTEIMDDSGKETNLPMGSVTYAIPVKIKEAAVGDSILYQTDSKAYRYMITEMDKKNHIFKVIDSSDKDAEPVAVEVKDYIPKVVITVGYAGYLLLATESIEGLIILGLAVLFLVILYIVAELLKKEPQDDYDETDTEPGYVKSKKELKREEKAREKRYKEEERQIKKEERVRRKGKAPERKKIKTGGFVDEIYEDELEPVKPAQPETIQTATSEAHELLRKEIAAATADVPVKQEESVQTKPDAGDIHMEPVSGKTEVIVPQVKEQLKQMMNASDRKPVEAEETEGNAQEEIRRMVIPTWSAAQIAETARSQGDAPDIVRDDVTKVTLFDYSDIIADEKPVYPQKQTAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BWF6</accession>
    <name>A0A174BWF6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-xylosidase</fullName>
            <ecNumber evidence="4">3.2.1.177</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yicI_4</name>
        <name evidence="4" type="ORF">ERS852478_01708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.177" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200171.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05013">
        <property type="protein sequence ID" value="CUO05013"/>
        <property type="gene ID" value="ERS852478_01708"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061634">
        <property type="term" value="F:alpha-D-xyloside xylohydrolase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5110" evidence="3">
        <location>
            <begin position="614"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO05013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="797" mass="92026" checksum="5F97A2FAE43B7FE5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BXE7</accession>
    <name>A0A174BXE7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01729</name>
        <name evidence="3" type="ORF">GT712_12210</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578292.1">
        <property type="nucleotide sequence ID" value="NZ_WWVN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05772">
        <property type="protein sequence ID" value="CUO05772"/>
        <property type="gene ID" value="ERS852478_01729"/>
    </dbReference>
    <dbReference type="GeneID" id="66492345"/>
    <dbReference type="eggNOG" id="ENOG502Z9CR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025647">
        <property type="entry name" value="YceG_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14266">
        <property type="entry name" value="YceG_bac"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YceG_bac" evidence="1">
        <location>
            <begin position="25"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="YceG_bac" evidence="1">
        <location>
            <begin position="270"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO05772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS89816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="757" mass="87916" checksum="634EDD8989061371" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BY33</accession>
    <name>A0A174BY33_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06131">
        <property type="protein sequence ID" value="CUO06131"/>
        <property type="gene ID" value="ERS852478_01742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO06131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="34" mass="3812" checksum="6076E8332E129F4F" modified="2016-09-07" version="1">MIVLHNLTGDTEKGAASFVVKLLYINDVNVWHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C2Q2</accession>
    <name>A0A174C2Q2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="13">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="13">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 17" type="primary">metG</name>
        <name evidence="17" type="ORF">ERS852478_01739</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="13"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200210.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06058">
        <property type="protein sequence ID" value="CUO06058"/>
        <property type="gene ID" value="ERS852478_01739"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="match status" value="2"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="551"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="13">
        <location>
            <begin position="13"/>
            <end position="23"/>
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    <feature type="binding site" evidence="13">
        <location>
            <position position="128"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
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            <position position="131"/>
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        <ligand>
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        </ligand>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
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    <sequence length="652" mass="74106" checksum="67074EC147B5937C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C3B7</accession>
    <name>A0A174C3B7_9FIRM</name>
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        <submittedName>
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        <submittedName>
            <fullName evidence="3">Dihydropteroate synthase</fullName>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">metH_3</name>
        <name evidence="4" type="synonym">acsE_1</name>
        <name evidence="4" type="ORF">BWLFYP14_01201</name>
        <name evidence="2" type="ORF">ERS852478_01789</name>
        <name evidence="3" type="ORF">GT728_05625</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 7">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="ERS852478_01789"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102036">
        <property type="term" value="F:methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:pteridine-containing compound metabolic process"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO07624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX63842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="272" mass="29681" checksum="59712CA3FD5F4300" modified="2016-09-07" version="1">MIIIGEKINGSIPIVAEAIAKRDSEFIKARAKLQAESGATYIDCCASVPEAEEVETLKWMIDCIQEVTDLPISIDSPSPDVLAQAYKFCKKPGIFNSVSGEGHKIDTIFPIMAEPGNEGWQVIALLSDNTGIPKCAADRLKVFDKIMAKAKEYGIAPDRIHIDPLVEMLCTSEDGIATNIETITSVREQYPTIHITAAISNISFNLPVRKLINYGFLVLAMNAGLDSGIMDPTNKDMLGLVYATEALLGLDDYCMEYIGAYREGLIGTTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CPK9</accession>
    <name>A0A174CPK9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF2500)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_02181</name>
        <name evidence="1" type="ORF">ERS852478_01952</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703590.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13526">
        <property type="protein sequence ID" value="CUO13526"/>
        <property type="gene ID" value="ERS852478_01952"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50341N9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019635">
        <property type="entry name" value="DUF2500"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10694">
        <property type="entry name" value="DUF2500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO13526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX65816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="67" mass="8114" checksum="2BFF17A747901A3D" modified="2016-09-07" version="1">MQSEAHVPWFRVVFEMTDGSLMEFQMQQGDFRELEKGDRGMLTYQGNRYICYQKYKFKSEAQEEEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CPX6</accession>
    <name>A0A174CPX6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidylate kinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Cytidylate kinase-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01995</name>
        <name evidence="3" type="ORF">GT712_10330</name>
        <name evidence="2" type="ORF">GT728_08955</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 5 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A1</strain>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000018">
        <property type="protein sequence ID" value="MZS89455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707544.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15601">
        <property type="protein sequence ID" value="CUO15601"/>
        <property type="gene ID" value="ERS852478_01995"/>
    </dbReference>
    <dbReference type="GeneID" id="66495614"/>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO15601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL33321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS89455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="208" mass="23609" checksum="DF1008112786B3AA" modified="2016-09-07" version="1">MSERKYPVITISREFGAGGHSIARVVSERLGIPYYDRDFAKQAAARSGYSQEDIDREGENLSRSARLLDNILNNSAGYFSSHDAIYQAQKELILQFAAEQDCIIIGRCSNLILRNAGIPSLDIFLHADVNLRTEHIQKLGLNGKEDPRKYLTKMDNLRETYFKTYTKHELGTYHDYDLCLDTGTLGYDNCIEIITSLAKQQGLNLKHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CQX6</accession>
    <name>A0A174CQX6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkanesulfonate transporter substrate-binding subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TAXI family TRAP transporter solute-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_00414</name>
        <name evidence="2" type="ORF">ERS852478_01994</name>
        <name evidence="4" type="ORF">GT712_10335</name>
        <name evidence="3" type="ORF">GT728_08960</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000018">
        <property type="protein sequence ID" value="MZS89456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707541.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15573">
        <property type="protein sequence ID" value="CUO15573"/>
        <property type="gene ID" value="ERS852478_01994"/>
    </dbReference>
    <dbReference type="GeneID" id="66495613"/>
    <dbReference type="eggNOG" id="COG2358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011852">
        <property type="entry name" value="TRAP_TAXI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42941">
        <property type="entry name" value="PTHR42941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16868">
        <property type="entry name" value="NMT1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02122">
        <property type="entry name" value="TRAP_TAXI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252611" evidence="1">
        <location>
            <begin position="37"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO15573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX62310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="333" mass="35508" checksum="2C52CA34F94CC16B" modified="2016-09-07" version="1">MRNKELFRGRRKAGRIVGLVLTLALAVSLLSGCGQSKERLTFGTGGTAGTYYSYGGVLAQYITNNTNVKVTAVSTGGSKANLQSVQDGDFQLGFVQSDVMAYAWDGVRAFEQDGATHDFRTLGGLYAETVQLFTMDPDIKTVEDLKGKSVSIGAANSGVYFNALDVLNAGGITLDDIHPQYLSFEDSKESLKDGKIDAAFIVAGAPTTAITELATTNGVYMINIDGAIRDSILSDCPYYTSYQIPAGTYPGQDEPVETITVKATIVVSESLDEDTVYDMTAAIFDHADEISAENAKGAELSLENATSGMTIPFHKGAARYYAEHGITVDTKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CV77</accession>
    <name>A0A174CV77_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional chorismate mutase/prephenate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Chorismate mutase-prephenate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">p-protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">pheA</name>
        <name evidence="22" type="ORF">ERS852478_02042</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200511.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17084">
        <property type="protein sequence ID" value="CUO17084"/>
        <property type="gene ID" value="ERS852478_02042"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="19">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate dehydratase" evidence="20">
        <location>
            <begin position="111"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="21">
        <location>
            <begin position="300"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="18">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CUO17084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="376" mass="43204" checksum="E526E118B4B89FC2" modified="2016-09-07" version="1">MIDLQECRNEIDKIDSDIIRLFEQRMKVCEDVAEYKIRTGKKVLDPERERQKLEVLRGKAHGEFNQLGAQELFQQIMAISRKRQYQLLTEHGIEDDEKLEMVDALPLKDVRVVFQGVEGAYSYAAMREYFQDDIESFHVKTWRDAMEAVVEGRADYAVLPIENTTAGIVADIYDLLTEYELSIVGEQIIRPEHVLLGLSDAELEDIRQVCSHPQALSQCGKYLESHPDWKKKEMENTAGSAKKIKEDNDKTQAAIASRQAGELYGLKILAENICYNGQNATRFVIVSKKPIYVKDAHKISIFFELHHESGTLYNMLSHIIYNGLNMTKIESRPITGKNWQYRFFVDFEGNLKDSAVKNALRGIEAEADRMRILGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CVH3</accession>
    <name>A0A174CVH3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">pyrB</name>
        <name evidence="11" type="ORF">BWLFYP14_02399</name>
        <name evidence="9" type="ORF">ERS852478_02045</name>
        <name evidence="10" type="ORF">ERS852523_00044</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
            <strain evidence="10 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO95355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX66028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993668.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2211"/>
    <dbReference type="EnsemblBacteria" id="CUO17203">
        <property type="protein sequence ID" value="CUO17203"/>
        <property type="gene ID" value="ERS852478_02045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95355">
        <property type="protein sequence ID" value="CUO95355"/>
        <property type="gene ID" value="ERS852523_00044"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="2"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="149"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO17203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO95355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX66028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="307" mass="34747" checksum="8ECCCBB67AF69FE2" modified="2016-09-07" version="1">MRHLMSPLDLSVDELNTLLDLASDIEKHPDKYAHVCDDKRLATLFYEPSTRTRLSFEAAMMNLGGKVLGFSSADSSSASKGESVADTIRVVSCYADICAMRHPKEGAPLVASMASSIPVINAGDGGHQHPTQTLTDLLTIRSLKGRLDNLTIGLCGDLKFGRTVHSLIEALVRYTNVKFILISPEELRIPSYIREDVLKKNNIEFQEVERLEDALPDLDILYMTRVQKERFFNEEDYVRMKDFYILDKQKMELAKKDMYILHPLPRVNEISTEVDADPRAAYFKQAQYGVYVRMALILTLLEVKLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D1H2</accession>
    <name>A0A174D1H2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19511">
        <property type="protein sequence ID" value="CUO19511"/>
        <property type="gene ID" value="ERS852478_02099"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO19511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="519" mass="58615" checksum="89E17BFA59ED0CA2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DK12</accession>
    <name>A0A174DK12_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Dihydroorotate oxidase B, electron transfer subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pyrK_2</name>
        <name evidence="7" type="synonym">pyrK</name>
        <name evidence="11" type="ORF">ERS852478_02234</name>
        <name evidence="13" type="ORF">GT712_11665</name>
        <name evidence="12" type="ORF">GT728_09330</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">BIOML-A1</strain>
            <strain evidence="13 15">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 9">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="7 9">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7 8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotetramer of 2 PyrK and 2 PyrD type B subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PyrK family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000018">
        <property type="protein sequence ID" value="MZL33394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000022">
        <property type="protein sequence ID" value="MZS89712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705492.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24240">
        <property type="protein sequence ID" value="CUO24240"/>
        <property type="gene ID" value="ERS852478_02234"/>
    </dbReference>
    <dbReference type="GeneID" id="66493785"/>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01211">
        <property type="entry name" value="DHODB_Fe_S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023455">
        <property type="entry name" value="Dihydroorotate_DHASE_ETsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000951">
        <property type="entry name" value="Ph_dOase_redase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="7 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 7 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="4"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="54"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="71"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO24240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL33394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS89712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="262" mass="28568" checksum="FD20B1FC03181E4E" modified="2016-09-07" version="1">MSEKTREICTVVSQESIGAGIYSMWIQTDRIAADAKPGQFVSLYTNDKSKILPRPISLCEIDKENGRLHLVYRVTGQGTGTDEFSQMKAGDTIPVLGPLGNGFPVEKAEGKKVFLMGGGIGVPPILELAKQMKCEKKQIIAGYRDCHTFLREEFEAAGTLYIATEDGSVGTKGNVMDAIRENALEADVIYACGPTPMLRAIKKYAEENGIECYISLEERMACGIGACLACVCKSREKDAHSNVNNKRICKDGPVFLSTEVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DM87</accession>
    <name>A0A174DM87_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BMC domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Carbon dioxide-concentrating mechanism protein CcmK homolog 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ccmK2_2</name>
        <name evidence="7" type="ORF">BWLFYP14_01562</name>
        <name evidence="3" type="ORF">ERS852478_02316</name>
        <name evidence="4" type="ORF">ERS852523_01625</name>
        <name evidence="6" type="ORF">GT712_12780</name>
        <name evidence="5" type="ORF">GT728_12255</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP44034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000029">
        <property type="protein sequence ID" value="MZL33951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705580.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000086_gene4007"/>
    <dbReference type="EnsemblBacteria" id="CUO26752">
        <property type="protein sequence ID" value="CUO26752"/>
        <property type="gene ID" value="ERS852478_02316"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP44034">
        <property type="protein sequence ID" value="CUP44034"/>
        <property type="gene ID" value="ERS852523_01625"/>
    </dbReference>
    <dbReference type="GeneID" id="66494433"/>
    <dbReference type="eggNOG" id="COG4577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO26752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP44034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL33951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS89922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX64708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="100" mass="10733" checksum="0FE47F8D1834B608" modified="2016-09-07" version="1">MSKSYGFIEITGVVAAIDALDIMCKTADVELASWERKLGGRLVTIIVEGDVSAVTEAVNAAATGAIKKPVSYAVIARPHEEIVRMVELSASRWKNNQGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DYE3</accession>
    <name>A0A174DYE3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug export protein mepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_11</name>
        <name evidence="2" type="ORF">ERS852478_02375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200733.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29196">
        <property type="protein sequence ID" value="CUO29196"/>
        <property type="gene ID" value="ERS852478_02375"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO29196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="457" mass="50304" checksum="78F80BC114048E70" modified="2016-09-07" version="1">MNEKEKVNQITEGVIWKQLLLFFFPIVFGTFFQQIYNTADTIVVGRFVGKQALAAVGGSASQIANLIVGFFVGLSSGAAVVISQFYGAKDKKNLSKALHTAFAFSIAAGIVLTVVGIFLTRPALLLMKTPADVVEDSAVYLHIYFGGMVFNLVYNMGAAILRAVGDSKRPLYVLIITCVLNIILDLLFVVAFGMGVTGVAVATVTSQVISALIVTVMLLKTREIYVLKINQIRFDRRMLFSVLRIGIPAGLESVMYNISNIVIQVFVNNLGTDTVAAWGTLGKIDAIFWMVINAFAISITTFVGQNFGAGKYHRMRKSVSVCMVMSMVSSAVMIILMYSFAPWIYRLFTTDSAVIVHGVHMSRFLLPSYFIYVIIGILSGALRGTGKVLVPMLLTCGGVCSLRILWLFTAGQMYPGINTIMLSYPVSWSITAVLFVVYYFMKFPGKEKAEHFRRQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E0F0</accession>
    <name>A0A174E0F0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cobalt-precorrin-4 C(11)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
            <ecNumber evidence="9">2.1.1.271</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Precorrin-4 C(11)-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.133</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cbiF</name>
        <name evidence="8" type="synonym">cobM</name>
        <name evidence="9" type="ORF">BWLFYP14_00105</name>
        <name evidence="7" type="ORF">ERS852478_02431</name>
        <name evidence="8" type="ORF">GT728_01845</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EC" id="2.1.1.271" evidence="9"/>
    <dbReference type="EC" id="2.1.1.133" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL31976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704809.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30947">
        <property type="protein sequence ID" value="CUO30947"/>
        <property type="gene ID" value="ERS852478_02431"/>
    </dbReference>
    <dbReference type="GeneID" id="66494318"/>
    <dbReference type="eggNOG" id="COG2875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO30947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL31976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="258" mass="28279" checksum="30D2E606F10EDE16" modified="2016-09-07" version="1">MVHFVGAGPGAPDLITVRGKQYLEEADVVIYAGSLVNPKLLEYTKDICTIYNSAKMTLEEVIHVIEKAEAEGKTTVRLHTGDPCIYGAIREQMDILDEKNITYDYCPGVSAFCGAASALNLEYTLPDISQSVIITRMEGRTPVPSKESIQSFAAHQATMVVFLSTGMLEELSRRLIEGGYTADTPAAIVYKATWPEQKTFVCTVGTLAKTAAENNITKTALMIIGDTVAAAHYDRSKLYDPEFTTEFREAVKSKTHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E269</accession>
    <name>A0A174E269_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ktr system potassium uptake protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ktrB_1</name>
        <name evidence="10" type="synonym">ktrB</name>
        <name evidence="10" type="ORF">BWLFYP14_00120</name>
        <name evidence="8" type="ORF">ERS852478_02416</name>
        <name evidence="9" type="ORF">ERS852523_01982</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
            <strain evidence="9 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000019">
        <property type="protein sequence ID" value="CUP55017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060043.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1144"/>
    <dbReference type="EnsemblBacteria" id="CUO30539">
        <property type="protein sequence ID" value="CUO30539"/>
        <property type="gene ID" value="ERS852478_02416"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP55017">
        <property type="protein sequence ID" value="CUP55017"/>
        <property type="gene ID" value="ERS852523_01982"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO30539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP55017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX66567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="445" mass="47531" checksum="5B4E83CDA88196D1" modified="2016-09-07" version="1">MPEKMCKKKHLTSFQLIILGFAGVILLGSILLMLPVSSLDKVPTPFHEALFTATSAVCVTGLVVKDSGSYWSVFGQTVILALIQIGGLGVVTVAAAVSLLSGKKISLMQRSTMQDAISAPKVGGIVRLTRFILKGTLLIEAAGAMLLLPVFVSDYGLKGIWMAAFHSVSAFCNAGFDILGTADNAFPSLTGYSGNILINVVIMLLIITGGIGFLTWDDIYRNKMNFKRYRMQSKIILMTTVCLIVFPAFFFFACDLKNLPAGERLLAAMFQSVTTRTAGFNTIDISEMSEASKAVMILLMLIGGSPGSTAGGMKTTTFTVLILNAIATFRSQENAGAFGRRLEYHVIKNAATIAMLYFTLFFCGGVAISVYEGLPLLDCLYEAASAVGTVGLTLGVTPGLHVFSQVVLIILMYLGRVGGLTLIYAVFSGRNKGNAKLPLEKITVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E586</accession>
    <name>A0A174E586_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ECF RNA polymerase sigma factor SigW</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor sigV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sigV_4</name>
        <name evidence="5" type="synonym">sigW_1</name>
        <name evidence="5" type="ORF">BWLFYP14_00803</name>
        <name evidence="4" type="ORF">ERS852478_02487</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000021">
        <property type="protein sequence ID" value="VUX63183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703676.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000158.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32933">
        <property type="protein sequence ID" value="CUO32933"/>
        <property type="gene ID" value="ERS852478_02487"/>
    </dbReference>
    <dbReference type="GeneID" id="66495237"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="109"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO32933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX63183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="172" mass="20366" checksum="DC0EDA8D795BC35E" modified="2016-09-07" version="1">MNEILIRKAKKGDKDAFCRLIDENVQSMYKVAAAYLKNDEDVADAIQDTILSCYENLKSLKQNRYFKTWMIRILINKCKDMIQKKKLVTYTDQMPETPFHEEKYAAMEWIQALEPLDSKYRLVVLLYYMEGFGIREISDILDMKESTVKSRLYRGRKQIAEMYGYKVKEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E602</accession>
    <name>A0A174E602_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluB</name>
        <name evidence="5" type="ORF">ERS852478_02496</name>
        <name evidence="6" type="ORF">GT712_02375</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380891.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33201">
        <property type="protein sequence ID" value="CUO33201"/>
        <property type="gene ID" value="ERS852478_02496"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO33201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS87968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="255" mass="28552" checksum="38AB72D85E0172B7" modified="2016-09-07" version="1">MKKAVRLDKFLADAGAGTRSEVKKFIQKGKVQVNGVPAKKSEIKVSEEDEVVLDGNRISQAPEFVYYLLHKPAGYVSATEDKRDKTVMELVASDRKGLFPVGRLDKDTEGLLLITDDGALAHELLSPKKHVDKTYYAVTDGCMTKEDVQHFADGLEIGEKNPTMPAKLEILSTRKVEETELEQYPSGWSSEIQLTIKEGKFHQVKRMTEAVGKKVVYLKRISMGVLTLPDDLKKGECRQLTAEEEKRLKESVVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E6A5</accession>
    <name>A0A174E6A5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO31939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31939">
        <property type="protein sequence ID" value="CUO31939"/>
        <property type="gene ID" value="ERS852478_02447"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO31939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="783" mass="89554" checksum="E360EBDDFBBEDF61" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EAQ3</accession>
    <name>A0A174EAQ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase sigma factor sigV</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Sigma-70 family RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sigV_5</name>
        <name evidence="5" type="ORF">ERS852478_02490</name>
        <name evidence="6" type="ORF">GT712_02415</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059636.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33070">
        <property type="protein sequence ID" value="CUO33070"/>
        <property type="gene ID" value="ERS852478_02490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="14"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="98"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO33070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS87975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="180" mass="21182" checksum="1CB82196210B7BE7" modified="2016-09-07" version="1">MTKDIFIKEVRDAEAMLYHISKSILKNDSDCGDAVQETILKAYEKLPTLKKEKYFRTWITKILINECNGILRKRKNVIPYEEYMDNMRLTEEDRYSHLYMAIMELPEDLRILVTLYYLEEFSQKEISEALDIPEGTIKSRLSRAREFLKAQLSDEEEKRPMPGKNSKPSKRITGKGKMSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EE01</accession>
    <name>A0A174EE01_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antirestriction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO34836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008393092.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34836">
        <property type="protein sequence ID" value="CUO34836"/>
        <property type="gene ID" value="ERS852478_02539"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009899">
        <property type="entry name" value="ArdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041895">
        <property type="entry name" value="ArdA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041896">
        <property type="entry name" value="ArdA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041893">
        <property type="entry name" value="ArdA_dom3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07275">
        <property type="entry name" value="ArdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO34836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="167" mass="19499" checksum="A28B87A86BFB802B" modified="2016-09-07" version="1">MIDDMAVYIANLGKYNEGYLVGAWFTFPIDEEDVKEKIGLNEQYEEYAIHDTDNFPIAIGEYVSIEELNEMYEMIEELPDYIVECLDEFISHYGTLEEVVEHKDDIYYYPDCETMTDVAYYYIDELQALGDIPASLQNYIDYEAYGRDLDMGGCFIETSRGMCEIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EGL7</accession>
    <name>A0A174EGL7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hca operon transcriptional activator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hcaR</name>
        <name evidence="3" type="ORF">ERS852478_02564</name>
        <name evidence="4" type="ORF">GT712_07200</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000011">
        <property type="protein sequence ID" value="MZS88857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052408.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35569">
        <property type="protein sequence ID" value="CUO35569"/>
        <property type="gene ID" value="ERS852478_02564"/>
    </dbReference>
    <dbReference type="GeneID" id="66494149"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO35569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="292" mass="33136" checksum="D4666E00F0FD3AB8" modified="2016-09-07" version="1">MELRLLRYFLTVAKEQSFTKAAEQLHITQPTLSRQMAAFEEDLGITLFIRNGKKISLTDEGILLKRRALEILNLEERTLEELKGKEEVVESTITIGCGEFAAVETLAKICKTYKEKYPLVQIVLHTATADAVYEMMNKGIVDIALFMEPVDTEGLDYIRITDCDHWCVGMRPDDPLAEKEFIKKEDLIGKPLILPERMNVQSELANWFGKDFSKLQIAFTSNLGTNAGVMAANGLGYPISIEGAAKYWREDILVQRRISPEIKTSTVIAWRRNIPYSLAVRKMIEEINAFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EGP3</accession>
    <name>A0A174EGP3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02434</name>
        <name evidence="1" type="ORF">ERS852478_02565</name>
        <name evidence="3" type="ORF">GT712_07205</name>
        <name evidence="2" type="ORF">GT728_02570</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">BIOML-A1</strain>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000011">
        <property type="protein sequence ID" value="MZS88858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000050">
        <property type="protein sequence ID" value="VUX66062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703857.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35599">
        <property type="protein sequence ID" value="CUO35599"/>
        <property type="gene ID" value="ERS852478_02565"/>
    </dbReference>
    <dbReference type="GeneID" id="66494148"/>
    <dbReference type="eggNOG" id="COG1694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11537">
        <property type="entry name" value="NTP-PPase_RS21-C6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025984">
        <property type="entry name" value="DCTPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12643">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029826">
        <property type="entry name" value="UCP029826_pph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO35599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL32102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS88858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="106" mass="12430" checksum="1CACBDD6E0911421" modified="2016-09-07" version="1">MKYETIDRIRKFTEDRNWDQFHSPANLAKSIVIEAAELLECFQWSDEEYDLQHVKEELADVLVYSQNLLDKLELDADEIINMKMSQNEAKYPVDKAKGSAAKYDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EJK5</accession>
    <name>A0A174EJK5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dus_2</name>
        <name evidence="14" type="synonym">dusC</name>
        <name evidence="14" type="ORF">BWLFYP14_00903</name>
        <name evidence="13" type="ORF">ERS852478_02640</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38152">
        <property type="protein sequence ID" value="CUO38152"/>
        <property type="gene ID" value="ERS852478_02640"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="12">
        <location>
            <begin position="32"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO38152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX63425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="335" mass="37533" checksum="F2EFACFFE7F8F37F" modified="2016-09-07" version="1">MQTRNEPVRAREPFMEMQWKIGNVQIDNPFVLAPMAGVTDLPFRTLCKEQGAGLICMEMISAKAISFHNKNTIALMEIDPCEHPVSMQLFGSEPDLMAEVAKSIEDRDFDILDINMGCPVPKVVNNGEGSALLKNPNLIEEIVRKVSSAISKPLTVKVRIGFENEPVDIVEIAKRIEDAGAAALAVHGRTRQQYYSGTADWDTIRRVKEAITIPVIGNGDVDSPLKAEALVKQTGCDAVMVGRAVRGNPWLFRELNHYFRTGELLERPSVEEIREMILRHARKQIELKGEFVGIREMRKHVAWYTAGMRHSAGLRRESNTIESYEALEALLSRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EUW6</accession>
    <name>A0A174EUW6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lgt_2</name>
        <name evidence="2" type="synonym">lgt</name>
        <name evidence="3" type="ORF">ERS852478_02748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200887.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41544">
        <property type="protein sequence ID" value="CUO41544"/>
        <property type="gene ID" value="ERS852478_02748"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO41544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="260" mass="28930" checksum="2FA6D8482240BBB9" modified="2016-09-07" version="1">MHNELLHIGPLTVYGYGFMIAMGVLAAWFVAEQRARKLKLACEHIFYLVVWCAIGGFISAKILFWITNWREFLQNPRQIIGSDGFVVYGGIIGGILVGWLYCRIKKLKFLKYFDLMMPSIALAQGFGRIGCFLAGCCYGKETSGPLAVTFTNSDFAPNNVALIPTQIYSGFLDFAHFLLLLYVAKHKKADGQVAACYLIFYSIGRFVIEFFRGDIERGSVGVLSTSQFISIFTTVAGIILLLTVVKKQKQEANISLNSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EW31</accession>
    <name>A0A174EW31_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42183">
        <property type="protein sequence ID" value="CUO42183"/>
        <property type="gene ID" value="ERS852478_02761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO42183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="73" mass="8193" checksum="834E44BD5A179846" modified="2016-09-07" version="1">MFRKEQIWFVHKDEEGVYVYSLADFTAQQGVRDTTDVMEKYRKGALGALPDPELINSLLSIKSGVKGDDADAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EYU8</accession>
    <name>A0A174EYU8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lytR_2</name>
        <name evidence="10" type="synonym">lytR_3</name>
        <name evidence="10" type="ORF">BWLFYP14_00547</name>
        <name evidence="8" type="ORF">ERS852478_02755</name>
        <name evidence="9" type="ORF">GT728_09680</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000019">
        <property type="protein sequence ID" value="MZL33462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707876.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41716">
        <property type="protein sequence ID" value="CUO41716"/>
        <property type="gene ID" value="ERS852478_02755"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="144"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO41716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX62769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="245" mass="28826" checksum="4DDEBF4CB2A7CA65" modified="2016-09-07" version="1">MKTIVVCDDVEIERLLLKEILCQYFEEINEEVSIVEYDSGETLIADVEEGYIAMDLLFLDICMKKLNGMETARKLRQIQCKVPIIFLTASPDYAIESYEVQASGYLLKSFSEEKLMKLLNRILKTDMKRRVAIKNRRQYRYPCTDDIMYIDSDKHNVTLHLSDGSEIITVDKLGEIEKRINEKRFLRCHQSYLVNMDYIKDVEDDFIMEDGTLVPIRVRGRKEILDTYYDYFVNHFGDSKDTFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZ13</accession>
    <name>A0A174EZ13_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sortase (Surface protein transpeptidase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200874.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41280">
        <property type="protein sequence ID" value="CUO41280"/>
        <property type="gene ID" value="ERS852478_02739"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05826">
        <property type="entry name" value="Sortase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005754">
        <property type="entry name" value="Sortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023365">
        <property type="entry name" value="Sortase_dom-sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009835">
        <property type="entry name" value="SrtB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04203">
        <property type="entry name" value="Sortase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63817">
        <property type="entry name" value="SSF63817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03064">
        <property type="entry name" value="sortase_srtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO41280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="270" mass="30814" checksum="5E695CD43B06A1A9" modified="2016-09-07" version="1">MSEKQPKKKKTAGDVVLTVVLIAAICVFCYAGYNLFHIYTEYKKGTDEYNSITQMAVTERDPDGEAAGPEAGSELKAPMDIDFASLKSVNDDVVGWIYVEAVPDINYPIVHGKDNETYLHRTYEKNYNFAGTIFVDYENKGDFSDCNTIVYGHNMKNGSMFAQLKKFTQDEETYKKSKYFWIFTPEKNYRYEIISAYTTGVNSDTYTLFKGPGEEFEKYLEKIRGYSEIRTDAEGMNIKDKIITLSTCTGNEATRYVVQGKRVDTLDIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F149</accession>
    <name>A0A174F149_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SirA-like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Sulfurtransferase TusA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BWLFYP14_01078</name>
        <name evidence="3" type="ORF">ERS852478_02774</name>
        <name evidence="4" type="ORF">ERS852523_02217</name>
        <name evidence="6" type="ORF">GT712_06940</name>
        <name evidence="5" type="ORF">GT728_15785</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000022">
        <property type="protein sequence ID" value="CUP61786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000046">
        <property type="protein sequence ID" value="MZL34615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000010">
        <property type="protein sequence ID" value="MZS88811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705273.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000048_gene1279"/>
    <dbReference type="EnsemblBacteria" id="CUO42638">
        <property type="protein sequence ID" value="CUO42638"/>
        <property type="gene ID" value="ERS852478_02774"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP61786">
        <property type="protein sequence ID" value="CUP61786"/>
        <property type="gene ID" value="ERS852523_02217"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="11"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO42638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP61786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL34615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS88811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX63720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="83" mass="9432" checksum="4F14A752C6C62D96" modified="2016-09-07" version="1">MAELDFEVTDEVDITDKVCPLTFVKAKVAIEELEDGEILAVRMNDGEPVQNVPRSMKEEGHKVLKLTDNEDGTYTMYVRKVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F5X7</accession>
    <name>A0A174F5X7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">(R)-stereoselective amidase</fullName>
            <ecNumber evidence="4">3.5.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ramA</name>
        <name evidence="4" type="ORF">ERS852478_02851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.100" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44957">
        <property type="protein sequence ID" value="CUO44957"/>
        <property type="gene ID" value="ERS852478_02851"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO44957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="269" mass="30827" checksum="72DF4841AAD19A37" modified="2016-09-07" version="1">MKVAAIQMPTVKDKMQNIRTAGTYIEKIKAENPDFVILPEMFCCPYQTENFPVYAEKEGGPSWQAMSDYARKYHIYLIAGSMPEADDSGNVYNTSYIFDRDGKQIGKHRKAHLFDINVKNGQHFKESDTLTSGDHATVFDTEFGKMGVMICYDIRFPEFARTMVLDGARMIFVPAAFNMTTGPAHWELTFRARALDNQIYMLGCAPARDTQAGYISWGHSIVTDSWGKVMKQLDEKEGILIEEIDLDREDQIREQLPLLKHRKSEMYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F7U0</accession>
    <name>A0A174F7U0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase</fullName>
            <ecNumber evidence="3">2.7.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thiD_2</name>
        <name evidence="3" type="ORF">ERS852478_02881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThiD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.49" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200980.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45781">
        <property type="protein sequence ID" value="CUO45781"/>
        <property type="gene ID" value="ERS852478_02881"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="2">
        <location>
            <begin position="11"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO45781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="269" mass="28771" checksum="9D593352A8FC07C4" modified="2016-09-07" version="1">MRTALTIAGSDSSGGAGIQADIKTMITNGVYAMSAITALTAQNTTGVQAILNVTPEFLGQELDSVFQDIYPDAVKIGMVSDKNLIHVIAEKLKQYKAENIVVDPVMVATSGAKLISDDAVEILKQELFPLADVLTPNIPEAEVLVEMSVTNAEEMIEAAGKISETYHCAVLCKGGHSINDANDLLYYDGKYCWFEGKRIDNPNTHGTGCTLSSAIASNLAKGYDLQTAVKRSKQYISGALAAMLDLGKGSGPMDHGFAIRNEYVKESEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FFK4</accession>
    <name>A0A174FFK4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_03388</name>
        <name evidence="1" type="ORF">ERS852478_02927</name>
        <name evidence="2" type="ORF">ERS852523_03101</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000039">
        <property type="protein sequence ID" value="CUP87041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47190">
        <property type="protein sequence ID" value="CUO47190"/>
        <property type="gene ID" value="ERS852478_02927"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP87041">
        <property type="protein sequence ID" value="CUP87041"/>
        <property type="gene ID" value="ERS852523_03101"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZVJK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO47190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP87041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX67111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="48" mass="5624" checksum="774990BB90911E45" modified="2016-09-07" version="1">MLLADFCRFIAVLVNNAFKTVQQSAKDKEDICRRANARQRYLTQDFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FSN7</accession>
    <name>A0A174FSN7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dpnA</name>
        <name evidence="9" type="ORF">ERS852478_03101</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:16857"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:13674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:137933"/>
            <dbReference type="EC" id="2.1.1.113"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201159.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53264">
        <property type="protein sequence ID" value="CUO53264"/>
        <property type="gene ID" value="ERS852478_03101"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015667">
        <property type="term" value="F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017985">
        <property type="entry name" value="MeTrfase_CN4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00093">
        <property type="entry name" value="N4_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO53264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="319" mass="35501" checksum="654E97F13D84D709" modified="2016-09-07" version="1">MKTDVIINRDALCALQELPSESVHCCVTSPPYFALRDYGLDAQIGQEDTPEQYIDRLTAVFGELYRVLRKDGTLWLNIADTYCGTGNKGGYADPKNPKGRTGQGLARNSRVTGCKQKDLIGIPWLLAFSLREQGWYLRSDIIWQKQNPMPESCKDRPTRCYEHIFLLSKEKKYYYDAAAIAEPLAPTTAERYRRARSTNSKYTQEIPGQGKVQGLNRPRDGGYYDDALMPTTRNKRDVWLINTVPYKGAHFAAFPPKLAETCILAGCPKGGIVLDPFFGSGTTGLAAKSLDRHYIGIELNAEYCALARARIGGAGLSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FV32</accession>
    <name>A0A174FV32_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted choloylglycine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO54073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579839.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000019.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A174FV32"/>
    <dbReference type="EnsemblBacteria" id="CUO54073">
        <property type="protein sequence ID" value="CUO54073"/>
        <property type="gene ID" value="ERS852478_03130"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4927">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO54073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="336" mass="38471" checksum="D8562AE3DB71009F" modified="2016-09-07" version="1">MYHAHFRGTHYEAGFRWGSLLLKHKNIILENIPFEITQERIDYALSCLPIYEKYYHEIVEEIQGLADGQQCDVRILQAVLFSMYSMPPSCNCSCFAFTTEQEILLGRNSDFLTEIERLNQNVVYKLTDGVYSFTGNTTAFIEIEDGVNEHGLAVGLTSVYPNQCKPGFNAGMIVRYLLEKCRNVSEAVSCLYQLPIASAQTLTLADTMGAIAVIECNAEQIKIEKTLNSNIAFVCATNTFHLPGMVGYNNDKIDNWFAEERYQTLYSAFSEKNGGFNFPFAEKLLSGDYGFLCQYDRSTGKDTVWSVIYDMKRHKIYRSEGNPRRHKFKEDIRFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FXJ3</accession>
    <name>A0A174FXJ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anaerobic benzoate catabolism transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002595107.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPF010000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53556">
        <property type="protein sequence ID" value="CUO53556"/>
        <property type="gene ID" value="ERS852478_03111"/>
    </dbReference>
    <dbReference type="GeneID" id="57969717"/>
    <dbReference type="GeneID" id="64114874"/>
    <dbReference type="GeneID" id="66495703"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO53556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="65" mass="7709" checksum="E78CF2CDEB0D9DF3" modified="2016-09-07" version="1">MKNRLEELRKQRGIKQEDLANALEVSRQTIGSLENGRYNPSIQLAFKIARYFNMSIEEIFIYEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G0F1</accession>
    <name>A0A174G0F1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bacitracin export permease protein BceB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">FtsX-like permease family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bceB_2</name>
        <name evidence="9" type="ORF">BWLFYP14_00681</name>
        <name evidence="8" type="ORF">ERS852478_03144</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO54648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000015">
        <property type="protein sequence ID" value="VUX62932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54648">
        <property type="protein sequence ID" value="CUO54648"/>
        <property type="gene ID" value="ERS852478_03144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="712"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="88"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO54648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX62932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="746" mass="84449" checksum="D4979DE76A874156" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G7V3</accession>
    <name>A0A174G7V3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-dehydro-2-deoxygluconokinase</fullName>
            <ecNumber evidence="2">2.7.1.92</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Carbohydrate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">iolC_2</name>
        <name evidence="2" type="ORF">ERS852478_03197</name>
        <name evidence="3" type="ORF">GT712_14555</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.92" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000032">
        <property type="protein sequence ID" value="MZS90257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381048.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56495">
        <property type="protein sequence ID" value="CUO56495"/>
        <property type="gene ID" value="ERS852478_03197"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047590">
        <property type="term" value="F:5-dehydro-2-deoxygluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="8"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO56495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="324" mass="35637" checksum="5BA561B3E4F35B9F" modified="2016-09-07" version="1">MGNKAFDVTALGELLIDFTENGSSAQGNPMLEANPGGAPCNVLAMLEKLGKKTAFIGKVGNDMFGTQLKNAVEEVGIDTRNLVIDNEVHTTLAFVHTYPDGDRDFSFYRNPGADMMLTKDEIQEDLIRDSRIFHFGTLSSTHEGVREATRYAIDVAKEAGCIISFDPNLRPPLWKSLDDAKAEIEYGLGKCDILKISDNEVEFLFGTTDYDKGAALLKEKYNIPLILITLGKDGSRAYYKDMKVEAAPFLQEKTIETTGAGDTFCASSLNYVLEHGLDNLTEENLKELLTFANAAASLITTRKGALRVMSTKEEVLDFMKSRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GJV5</accession>
    <name>A0A174GJV5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_03324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380271.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60715">
        <property type="protein sequence ID" value="CUO60715"/>
        <property type="gene ID" value="ERS852478_03324"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SE0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO60715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="85" mass="10050" checksum="EED0FA8D27DBA9E4" modified="2016-09-07" version="1">MSKWDKLITRICNLSKDLRFDELRKVLESYGYEMNVPRSGSSHYTFRKSGCMPITIPKHEPIKKVYVEMVREIVESEAKNHEDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GMM2</accession>
    <name>A0A174GMM2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase DDE domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO63892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201402.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63892">
        <property type="protein sequence ID" value="CUO63892"/>
        <property type="gene ID" value="ERS852478_03421"/>
    </dbReference>
    <dbReference type="GeneID" id="66495134"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="114"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO63892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="426" mass="49439" checksum="FBFEED36AA86508B" modified="2016-09-07" version="1">MSRTNICKNIVQSIKDYITDQVKLEPHRVEKHFVRRRKLSLLQVIIYLFFSSKASMFQNLSQIREELGTLSFPDVSKQALSKARQFINPSLFKELYYLSVDLFYSQIPSRKLWQGYHLFAVDGSRIELPNSKSTFDFFGEMSSYPDPNRRYTMGLASIIYDVLDDYILHASIHKFLSSERAAALEHLKVLEDMGLYNNSIIIFDRGYYSEDMFRYCVEHGHLCVMRLKEGINLSKKCNGDMISILQGTSKEGTSDVPIRVLEIPLDDGTKEYLATNLFDPAVTKDMFQELYFYRWPVELKYKELKSRFAMEEFSGATAVSIQQEFYINMLLSNLASLIKNEADEEIQISAKSTNKFRYQANRAFIIGRIKSIVPKILCGLFELSIIEQLYTDAVRCRSQLLPGRSFPRKKLKSKGRPHFRNKKASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GMM3</accession>
    <name>A0A174GMM3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201396.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPF010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63211">
        <property type="protein sequence ID" value="CUO63211"/>
        <property type="gene ID" value="ERS852478_03399"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032PN8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO63211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="90" mass="10418" checksum="B0DBE52D3971F02E" modified="2016-09-07" version="1">MMYPFMTLNDDTEITHSEMKADGKVKVYIETPDEFGGFHNATCWLPDYRWEDIEGYSDTEMAYFKQLIRNNAHLIIEFSQEGGILNAANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GNE2</accession>
    <name>A0A174GNE2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="11">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">alaS_2</name>
        <name evidence="11" type="synonym">alaS</name>
        <name evidence="13" type="ORF">ERS852478_03410</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201386.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63481">
        <property type="protein sequence ID" value="CUO63481"/>
        <property type="gene ID" value="ERS852478_03410"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="12">
        <location>
            <begin position="4"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="668"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="672"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO63481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="879" mass="96458" checksum="2FF25CD3B1C77E55" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GNK2</accession>
    <name>A0A174GNK2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protoporphyrinogen oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO62967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201364.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62967">
        <property type="protein sequence ID" value="CUO62967"/>
        <property type="gene ID" value="ERS852478_03391"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004792">
        <property type="entry name" value="BaiN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023166">
        <property type="entry name" value="HI0933-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42887">
        <property type="entry name" value="PTHR42887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00275">
        <property type="entry name" value="TIGR00275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO62967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="454" mass="49445" checksum="04E338FC95ABE71D" modified="2016-09-07" version="1">MSKVIIIGGGAAGMMAGVFAARNHHEVHILEKNEKLGKKVFITGKGRCNVTNACDTEELFPAMMSNPKFLYSSFYSFTPQDVMEFFEKAGVPLKVERGNRVFPQSDHSSDIIRALERELKKAGAKIHLHTAVQEIVKKPVTDSVNTLESEATLTESGSDAGKSRKGKKSPDIQQEKITGVILTDGTFIEGDAVIVATGGFSYQSTGSTGDGYRFARELGLKVTDIAPSLVPLKTKEDYIPKLQGLSLKNTGLTIKNGKKVLYEDFGEMMFTHFGVTGPMILSASAHIGAKLAKAPNGELSAYLDLKPALTREQLDARILREFEAGPNKQFKNVIGVLFPSSLTPVMLELGGIPAEKKIHDISREERQHFIDLIKAFPFTITGMGEFKEAIITRGGVSVKEINPGTMESKKISGLYFAGEVLDLDAVTGGYNLQIAWSTAYLAAQAIRYCSLRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GNP0</accession>
    <name>A0A174GNP0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF2290 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein (DUF2290)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02269</name>
        <name evidence="1" type="ORF">ERS852478_03435</name>
        <name evidence="2" type="ORF">GT712_16265</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000042">
        <property type="protein sequence ID" value="MZS90572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704368.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000068.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64262">
        <property type="protein sequence ID" value="CUO64262"/>
        <property type="gene ID" value="ERS852478_03435"/>
    </dbReference>
    <dbReference type="GeneID" id="66495122"/>
    <dbReference type="eggNOG" id="COG5619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018742">
        <property type="entry name" value="DUF2290"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10053">
        <property type="entry name" value="DUF2290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO64262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS90572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="217" mass="25984" checksum="EFDA1987E38DE6A7" modified="2016-09-07" version="1">MKEQEKVFRELKKVTRELIRCGLAEEYNYPVIQQMDIVWEKYQNISLYLRNMDYSTIYDEIEKNHNYNVKLPDGGIIQLMYRFNRTGKELISHRLGYYPSPSYELYQNDPELYDVDYIYGDILNKSVLPVIIRADYNRDPEESELHHPYSHITLGGYKNCRIPVDRPISPMKFVKFIMEHFYYVPSSQLEFNFEIEGIVAFEEHIAEKDINKSRIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GP81</accession>
    <name>A0A174GP81_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription antitermination protein nusG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusG_2</name>
        <name evidence="6" type="ORF">ERS852478_03381</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO62709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201350.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62709">
        <property type="protein sequence ID" value="CUO62709"/>
        <property type="gene ID" value="ERS852478_03381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="5">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO62709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="168" mass="19660" checksum="9A9F081E34BCCF48" modified="2016-09-07" version="1">MWYVMQVRTGTEENIRCQCQRLISSNVLERCFILYYQQKKRFQGEWHIQERILFPGYVFLIAENQEKLVNGLRKVIGLTKLIGTGDEIVPLVQEEIDLLMKIGTDKQLVEMSSGIIENDRVQILAGPLMGMEGNIRRIDRHKRTAYLEIEMFGRTVEMKVGLEIIRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GPM9</accession>
    <name>A0A174GPM9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02275</name>
        <name evidence="1" type="ORF">ERS852478_03441</name>
        <name evidence="2" type="ORF">GT712_16235</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000042">
        <property type="protein sequence ID" value="MZS90566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058992.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000068.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64403">
        <property type="protein sequence ID" value="CUO64403"/>
        <property type="gene ID" value="ERS852478_03441"/>
    </dbReference>
    <dbReference type="GeneID" id="66495116"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO64403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS90566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="117" mass="13208" checksum="0E296123D1F736D6" modified="2016-09-07" version="1">MDVKDSISVTLKTIDGKETKDQSAKNIFSYKPIMSNILKYTVEEYRDCSLEEIMNCIEGDTIQIGTALVEEDMAKTIRGEDTEFHTTDEAPAAFDILFRSLNPKAEGKLLVNLHIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GT76</accession>
    <name>A0A174GT76_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">NADH oxidase</fullName>
            <ecNumber evidence="8">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BWLFYP14_02260</name>
        <name evidence="8" type="ORF">ERS852478_03426</name>
        <name evidence="10" type="ORF">GT712_16295</name>
        <name evidence="9" type="ORF">GT728_10890</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 15">BIOML-A1</strain>
            <strain evidence="10 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000024">
        <property type="protein sequence ID" value="MZL33690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000042">
        <property type="protein sequence ID" value="MZS90578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381268.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64029">
        <property type="protein sequence ID" value="CUO64029"/>
        <property type="gene ID" value="ERS852478_03426"/>
    </dbReference>
    <dbReference type="GeneID" id="66495128"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="6">
        <location>
            <begin position="5"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="7">
        <location>
            <begin position="391"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO64029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS90578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX65895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="936" mass="102438" checksum="2399B4E0B04FFADE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GX15</accession>
    <name>A0A174GX15_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidoglycan-N-acetylmuramic acid deacetylase PdaA</fullName>
            <ecNumber evidence="5">3.5.1.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Probable polysaccharide deacetylase pdaA</fullName>
            <ecNumber evidence="2">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pdaA</name>
        <name evidence="5" type="ORF">BWLFYP14_02337</name>
        <name evidence="2" type="ORF">ERS852478_03468</name>
        <name evidence="4" type="ORF">GT712_16590</name>
        <name evidence="3" type="ORF">GT728_16115</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.-" evidence="5"/>
    <dbReference type="EC" id="3.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65329">
        <property type="protein sequence ID" value="CUO65329"/>
        <property type="gene ID" value="ERS852478_03468"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10948">
        <property type="entry name" value="CE4_BsPdaA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014235">
        <property type="entry name" value="Spore_PdaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF78">
        <property type="entry name" value="PTHR10587:SF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="88"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO65329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="275" mass="31217" checksum="0FF634753EEC7372" modified="2016-09-07" version="1">MHLKYISSTRIFSSRFTKIFLLFCACAFIGSSIGKIVSHNTARQTAASAQSSNWGLSFQEEGKRPVGNATIEELAQYNAFFAEDTEEKKIYLTFDAGFENGNTPAILDALKKHQAPATFFVVGNFISENKDLIKRMETEGHIVGNHTMTHPDMSKISTKESFQKELSDVEKIYREITGKEMTKFYRPPQGIYSTQNLSMARELGYHTFFWSLAYVDWYQDNQPDPQEAIAKLTKRIHPGAIVLLHSTSSTNAQILDELLDKWEAMGYSFHSLNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GXM8</accession>
    <name>A0A174GXM8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese-like domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase PspE</fullName>
            <ecNumber evidence="2">2.8.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pspE_3</name>
        <name evidence="5" type="synonym">pspE</name>
        <name evidence="5" type="ORF">BWLFYP14_02355</name>
        <name evidence="2" type="ORF">ERS852478_03485</name>
        <name evidence="4" type="ORF">GT712_16500</name>
        <name evidence="3" type="ORF">GT728_16025</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.8.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708183.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65796">
        <property type="protein sequence ID" value="CUO65796"/>
        <property type="gene ID" value="ERS852478_03485"/>
    </dbReference>
    <dbReference type="GeneID" id="66493921"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO65796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="106" mass="11845" checksum="2CD39E1DC01A5523" modified="2016-09-07" version="1">MGFFDLFKQSNINQGIEEYKRTGDAVLLDVRTPQEYQEGHIPESKNVPLQQLDNIASVAKNKDIPLFVYCYSGSRSRQATGILQRMGYSKVNNIGGIAAYSGKVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H6U7</accession>
    <name>A0A174H6U7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional repressor yvoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yvoA_4</name>
        <name evidence="2" type="ORF">ERS852478_03583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO68928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002578893.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000102.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68928">
        <property type="protein sequence ID" value="CUO68928"/>
        <property type="gene ID" value="ERS852478_03583"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO68928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="127" mass="14046" checksum="77F0E8013BAD74E4" modified="2016-09-07" version="1">MKLIISNVSGVPIYEQIKQQIKAAILSGELQAEETLPSLRTLAKDLKISVLTVTKAYTELEQEGFVKNVQGRGCFVMGSGSELIKEQLICKVENNLTEAIKAARMANLSTEELHRLLDILTEVKTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H7L0</accession>
    <name>A0A174H7L0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="6">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GTP cyclohydrolase I</fullName>
            <shortName evidence="6">GTP-CH-I</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">folE</name>
        <name evidence="8" type="ORF">ERS852478_03650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homopolymer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381439.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000082.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70874">
        <property type="protein sequence ID" value="CUO70874"/>
        <property type="gene ID" value="ERS852478_03650"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="PTHR11109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP_cyclohydroI" evidence="7">
        <location>
            <begin position="7"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO70874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="185" mass="20948" checksum="B4DCECAEF62FE93B" modified="2016-09-07" version="1">MVDKAKIEQAVRLLLEGIGEDITREGLIDTPDRIARMCEEIYGGLGHEADQHLLKQFPVENNEIVLEKDITFYSMCEHHLMPFYGKAHLAYIPNGKVTGLSKLARTVEVYSRRPQIQERLTVQIADALERTLDPKGIMVMLEAEHTCMTMRGIKKPGSKTITTVTRGAFTEDKELQKMFLSMVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H9H7</accession>
    <name>A0A174H9H7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03674</name>
        <name evidence="2" type="ORF">GT712_06815</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BIOML-A12</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZS88788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201485.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000072.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71563">
        <property type="protein sequence ID" value="CUO71563"/>
        <property type="gene ID" value="ERS852478_03674"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO71563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS88788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="75" mass="8801" checksum="46375301A0E0CAE9" modified="2016-09-07" version="1">MQNKLFLKVADICELLEVKQTSAYEIIGNLNKELEEQGYLTLRGKVPTKYFVKRFYGVEDTCEIPQEEGKEWFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H9I3</accession>
    <name>A0A174H9I3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03615</name>
        <name evidence="2" type="ORF">ERS852523_02707</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO69878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000030">
        <property type="protein sequence ID" value="CUP75714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006859036.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000053.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000056_gene2498"/>
    <dbReference type="EnsemblBacteria" id="CUO69878">
        <property type="protein sequence ID" value="CUO69878"/>
        <property type="gene ID" value="ERS852478_03615"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP75714">
        <property type="protein sequence ID" value="CUP75714"/>
        <property type="gene ID" value="ERS852523_02707"/>
    </dbReference>
    <dbReference type="GeneID" id="61434859"/>
    <dbReference type="eggNOG" id="ENOG50312WU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045705">
        <property type="entry name" value="DUF6061"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19537">
        <property type="entry name" value="DUF6061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO69878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP75714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="79" mass="9199" checksum="4E2820CF98228D9C" modified="2016-09-07" version="1">MRTIYAEYNINHDSIDVYTSAGYMLRIDCWEAEKNLKTTYGSECALTSLAVDEPLEYARLYLDGNLQMWVDTEDSLELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HGH1</accession>
    <name>A0A174HGH1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphoglucomutase</fullName>
            <ecNumber evidence="11">5.4.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pgcA_2</name>
        <name evidence="11" type="ORF">ERS852478_03706</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000044">
        <property type="protein sequence ID" value="CUO72487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201497.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72487">
        <property type="protein sequence ID" value="CUO72487"/>
        <property type="gene ID" value="ERS852478_03706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="41"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="206"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="319"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="489"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO72487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="557" mass="61680" checksum="FFAE457183486EBF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HK81</accession>
    <name>A0A174HK81_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoside hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Pyrimidine-specific ribonucleoside hydrolase rihA</fullName>
            <ecNumber evidence="4">3.2.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rihA</name>
        <name evidence="4" type="ORF">ERS852478_03751</name>
        <name evidence="5" type="ORF">GT728_19155</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000046">
        <property type="protein sequence ID" value="CUO73717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000080">
        <property type="protein sequence ID" value="MZL35233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059817.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73717">
        <property type="protein sequence ID" value="CUO73717"/>
        <property type="gene ID" value="ERS852478_03751"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="6"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO73717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL35233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="329" mass="37203" checksum="9F113BE80CA7A18F" modified="2016-09-07" version="1">MKKRKVIIDCDPGIDDSLAIMLALKSPEIEVIGITIVCGNSPVEMGFGNAKKILKQMNRLDVPVYIGESTPLRRDYVNALDTHGEDGLGESFLPEVTGYQQQISAVDFLADVLKKEKVSIIELAPMTNLARLIQKDKEAFSCIEEIVSMGGSFKSHGNCSPVAEYNYWCDPDGASLVYETLHQNGQKIHMVGLDVTRKIVLTPDLLEYMCRLNKETGEFVKKITKFYFDFHWEWEHIIGCVINDPLAVAYFINPELCKGFDSYVQIETEGISLGQSVVDSMNFYRKTSNTRVLTEVDVYGFFQMFLSRILDQEPEELDILQDLIRGDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HMU4</accession>
    <name>A0A174HMU4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Uncharacterized HTH-type transcriptional regulator yybR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yybR_2</name>
        <name evidence="2" type="ORF">ERS852478_03826</name>
        <name evidence="4" type="ORF">GT712_15345</name>
        <name evidence="3" type="ORF">GT728_15655</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000055">
        <property type="protein sequence ID" value="CUO76234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000045">
        <property type="protein sequence ID" value="MZL34591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000037">
        <property type="protein sequence ID" value="MZS90406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993870.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76234">
        <property type="protein sequence ID" value="CUO76234"/>
        <property type="gene ID" value="ERS852478_03826"/>
    </dbReference>
    <dbReference type="GeneID" id="66494474"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO76234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="110" mass="12694" checksum="6551D423B5D9624E" modified="2016-09-07" version="1">MRAKEELPECPVATAVSLIGGKWKLLILRNLKERPWRFNELQRSIDGISQKVLTDSLRQMMSDGLAYRHDYHEQPPKVEYGLTELGTKMLPIVNSLADFGNYYKSIIEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HNP7</accession>
    <name>A0A174HNP7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000049">
        <property type="protein sequence ID" value="CUO74710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74710">
        <property type="protein sequence ID" value="CUO74710"/>
        <property type="gene ID" value="ERS852478_03782"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO74710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="51" mass="6144" checksum="3747791173D07B8F" modified="2016-09-07" version="1">MKGYNTSNGYMGYVEGKYILFASEQEYFEFMHYRGYIYVILELVLKDLVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JAY9</accession>
    <name>A0A174JAY9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aliphatic sulfonates transport permease protein SsuC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Putative aliphatic sulfonates transport permease protein ssuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ssuC_1</name>
        <name evidence="7" type="synonym">ssuC_2</name>
        <name evidence="9" type="ORF">BWLFYP14_00402</name>
        <name evidence="7" type="ORF">ERS852478_01982</name>
        <name evidence="8" type="ORF">ERS852523_00101</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
            <strain evidence="8 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO96862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2266"/>
    <dbReference type="EnsemblBacteria" id="CUO15175">
        <property type="protein sequence ID" value="CUO15175"/>
        <property type="gene ID" value="ERS852478_01982"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96862">
        <property type="protein sequence ID" value="CUO96862"/>
        <property type="gene ID" value="ERS852523_00101"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO15175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO96862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX62286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="264" mass="29524" checksum="9620556FEB9E7E99" modified="2016-09-07" version="1">MMSEISYHQQQYIRHQKREKKLVLFLRIFILLFFLVLWEISARTGLIDSFIFSSPVMIWHSFCSMCRDGSIFPHLSVTITETLVSFLFVVVLGAGMAVLLWTCPRLAKITEPYLVVLNSLPKSALAPLLIVWLGANERTIIVCGMSVAIFGSILNLYTGFGEADPEKLKLIETLGGGKKEKLMKIILPSSVPLLLSVMKVNIGLCLVGVIIGEFIGARKGLGYLIIYSSQTFKLTWVLMSIIILCIIAIILYGLLGLIEKRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JUS4</accession>
    <name>A0A174JUS4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yqgN</name>
        <name evidence="6" type="ORF">BWLFYP14_02660</name>
        <name evidence="4" type="ORF">ERS852478_00162</name>
        <name evidence="5" type="ORF">ERS852523_00319</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
            <strain evidence="5 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000003">
        <property type="protein sequence ID" value="CUP03514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703219.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000032_gene395"/>
    <dbReference type="EnsemblBacteria" id="CUN45327">
        <property type="protein sequence ID" value="CUN45327"/>
        <property type="gene ID" value="ERS852478_00162"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03514">
        <property type="protein sequence ID" value="CUP03514"/>
        <property type="gene ID" value="ERS852523_00319"/>
    </dbReference>
    <dbReference type="GeneID" id="66495861"/>
    <dbReference type="eggNOG" id="COG0212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="4"/>
            <end position="8"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="129"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN45327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP03514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="185" mass="21179" checksum="C6C504E39A3CB520" modified="2016-09-07" version="1">MESKKDIRKKIFAERKLHTDEQIEAMSRTITDKVTALPAFKNADRILVYADYNHEVVTEYLIKEAWKAGKEVAVPKVVGKDMVFYKLTDFARLEPGYFGIPEPVSGEIVNWSKALMIMPGVAFDRANHRVGYGGGFYDRYLEKHPQLERVAIAFSFQMLPEVPTEPTDICPQIIVTEEEICYLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KBE9</accession>
    <name>A0A174KBE9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 12">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">fabF</name>
        <name evidence="20" type="ORF">BWLFYP14_03091</name>
        <name evidence="16" type="ORF">ERS852478_01143</name>
        <name evidence="17" type="ORF">ERS852523_00464</name>
        <name evidence="19" type="ORF">GT712_03480</name>
        <name evidence="18" type="ORF">GT728_00740</name>
    </gene>
    <organism evidence="17 22">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 21 22" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 21">2789STDY5834863</strain>
            <strain evidence="17 22">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="18 24 25" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 25">BIOML-A1</strain>
            <strain evidence="19 24">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="20 23" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 14">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 12"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP07397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026649079.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2159"/>
    <dbReference type="EnsemblBacteria" id="CUN81687">
        <property type="protein sequence ID" value="CUN81687"/>
        <property type="gene ID" value="ERS852478_01143"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07397">
        <property type="protein sequence ID" value="CUP07397"/>
        <property type="gene ID" value="ERS852523_00464"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="15">
        <location>
            <begin position="4"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUN81687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUP07397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MZL31760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MZS88173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VUX66815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="411" mass="43857" checksum="594B5BC36207C08E" modified="2016-09-07" version="1">MRRVVITGMGAITPVGLSVEEFWNSVKEGKTNFAEVTRFDSTNYRAHMAAEINNFNPKDYMDFKSAKRMELFSQYAVAAAKEAIEQSGLDMTKEDPFRVGCSVGSGIGSMQVVEKSCEILNTKGPGRLNPLMIPLLISNMASGNVSIQFGLRGKNINVVTACATGTHSIGEAYRTIQCSDADVMVAGGTEAAITPTGFGGFAALTALTSSTDPERCSIPFDKERSGFVMGEGAGVVVLEELEHAKARGAKILGEVVGYGATGDAYHITSPAEDGSGAAKAMEWAVKEAGISTDDVWYVNAHGTSTHHNDLFETIAIKKTFGEHAKEMKINSTKSITGHLLGAAGAVEVITCVKELQEGLIHQTVGYKVPDEQCDLDYVGNGNVKMDIKYALTNSLGFGGHNASLLIKKYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L0T7</accession>
    <name>A0A174L0T7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferric uptake regulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fur_2</name>
        <name evidence="1" type="synonym">fur_1</name>
        <name evidence="3" type="ORF">BWLFYP14_02566</name>
        <name evidence="1" type="ORF">ERS852478_00065</name>
        <name evidence="2" type="ORF">ERS852523_00702</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP15169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1428"/>
    <dbReference type="EnsemblBacteria" id="CUN42702">
        <property type="protein sequence ID" value="CUN42702"/>
        <property type="gene ID" value="ERS852478_00065"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15169">
        <property type="protein sequence ID" value="CUP15169"/>
        <property type="gene ID" value="ERS852523_00702"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN42702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP15169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="157" mass="18167" checksum="8F31A50BB2825257" modified="2016-09-07" version="1">MGAAALQRQENCKEPNYQRTRMQKDVVIQELKKRGCRITKQRRMLLEVILENECSCCKEIYYNASRLDPGIGSATVYRMVNLLEEIGAISRRNMYKIVRNPDCKDESVCTIELDDNTVQKLSKDSFNNVVLTGLKACGYIDKQEIERMFVNSCDFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L1L9</accession>
    <name>A0A174L1L9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF2325 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein conserved in bacteria (DUF2325)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_02561</name>
        <name evidence="2" type="ORF">ERS852478_00060</name>
        <name evidence="3" type="ORF">ERS852523_00707</name>
        <name evidence="5" type="ORF">GT712_07605</name>
        <name evidence="4" type="ORF">GT728_03140</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0751 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP15300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000005">
        <property type="protein sequence ID" value="MZL32215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703057.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1424"/>
    <dbReference type="EnsemblBacteria" id="CUN42542">
        <property type="protein sequence ID" value="CUN42542"/>
        <property type="gene ID" value="ERS852478_00060"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15300">
        <property type="protein sequence ID" value="CUP15300"/>
        <property type="gene ID" value="ERS852523_00707"/>
    </dbReference>
    <dbReference type="GeneID" id="66492872"/>
    <dbReference type="eggNOG" id="ENOG5032SEK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016772">
        <property type="entry name" value="UCP020408"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10087">
        <property type="entry name" value="DUF2325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN42542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP15300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="91" mass="9943" checksum="3FA1E664FB58B629" modified="2016-09-07" version="1">MSIVIVGGHDRMVGQYKKICKSYKCKCKVFTQMEADFGKKIGCPDLLVLFTNTVSHKMVKCALDEVGASTDIVRCHTSSGNALNGILEARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LX02</accession>
    <name>A0A174LX02_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Holin-like protein CidB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">LrgB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cidB</name>
        <name evidence="9" type="ORF">BWLFYP14_01302</name>
        <name evidence="6" type="ORF">ERS852478_00931</name>
        <name evidence="7" type="ORF">ERS852523_01133</name>
        <name evidence="8" type="ORF">GT728_01335</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">2789STDY5834863</strain>
            <strain evidence="7 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000009">
        <property type="protein sequence ID" value="CUP28712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380929.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000054_gene1890"/>
    <dbReference type="EnsemblBacteria" id="CUN73483">
        <property type="protein sequence ID" value="CUN73483"/>
        <property type="gene ID" value="ERS852478_00931"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP28712">
        <property type="protein sequence ID" value="CUP28712"/>
        <property type="gene ID" value="ERS852523_01133"/>
    </dbReference>
    <dbReference type="GeneID" id="66493046"/>
    <dbReference type="eggNOG" id="COG1346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007300">
        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249">
        <property type="entry name" value="PTHR30249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04172">
        <property type="entry name" value="LrgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN73483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP28712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL31875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX64237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="230" mass="24244" checksum="306ED0E0F21C822C" modified="2016-09-07" version="1">MTQFMSNSLFFGAAISLIAYEAGLLLKRKFKMAIFNPLLIAIIAVIAVLCLLHIDYDTYNQSGQYISYLLTPATVCLAVPLYQQMELLKKNLKAVIIGIVSGVLASLVSVLILAKLFSLSHEQYVTLLPKSITTAIGMGVSEELGGIVTITVAVIIITGVLGNMIAETVIKLARIEEPIAKGLALGTSAHAIGTAKAMELGEIEGAMSSLAIAVAGLLTVVGASVFAQFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174N133</accession>
    <name>A0A174N133_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diaminopimelate epimerase</fullName>
            <shortName evidence="3">DAP epimerase</shortName>
            <ecNumber evidence="3">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dapF_2</name>
        <name evidence="3" type="synonym">dapF</name>
        <name evidence="4" type="ORF">ERS852478_02967</name>
        <name evidence="5" type="ORF">ERS852523_01484</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
            <strain evidence="5 7">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP39679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000028_gene195"/>
    <dbReference type="EnsemblBacteria" id="CUO48567">
        <property type="protein sequence ID" value="CUO48567"/>
        <property type="gene ID" value="ERS852478_02967"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP39679">
        <property type="protein sequence ID" value="CUP39679"/>
        <property type="gene ID" value="ERS852523_01484"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="223"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="3">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO48567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP39679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="282" mass="30671" checksum="A67B481C1D410830" modified="2016-09-07" version="1">MANTIIMSKYQGLGNDYLILDPKKNQVQLQGKKIALLCQRGFGLGADGVLYGPVEIDGKLGVRIFNADGSESAISGNGVRIFAKYLMDNGYITEKKFDIETMSGTIHVECLNSRATEFKVNIGKPSFISSDIPVSGEVREVIKENFVFHGKEYKATCLTVGNPHCIIFTDNVSAEAVKNLGPYVENADEFPERMNLQICRQVDKGNLEIEIWERGSGYTKASGTGSCAAAAAAYKLGLVESRINVNQPGGMIQIDMEEDGTIYMTGTVGYIADISVAESFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NLC5</accession>
    <name>A0A174NLC5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P protein component</fullName>
            <shortName evidence="5">RNase P protein</shortName>
            <shortName evidence="5">RNaseP protein</shortName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rnpA</name>
        <name evidence="9" type="ORF">BWLFYP14_02847</name>
        <name evidence="6" type="ORF">ERS852478_02186</name>
        <name evidence="7" type="ORF">ERS852523_01712</name>
        <name evidence="8" type="ORF">GT712_11390</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">2789STDY5834863</strain>
            <strain evidence="7 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000015">
        <property type="protein sequence ID" value="CUP46819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708005.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000021_gene1695"/>
    <dbReference type="EnsemblBacteria" id="CUO22229">
        <property type="protein sequence ID" value="CUO22229"/>
        <property type="gene ID" value="ERS852478_02186"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP46819">
        <property type="protein sequence ID" value="CUP46819"/>
        <property type="gene ID" value="ERS852523_01712"/>
    </dbReference>
    <dbReference type="GeneID" id="66493378"/>
    <dbReference type="eggNOG" id="COG0594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO22229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP46819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS89659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="123" mass="14289" checksum="7208CA0FC8EE0A9C" modified="2016-09-07" version="1">MQRSESLKKNQDFQKVYRNGTSKGNRYLVMYVLKNQYMKNRLGISVSKKVGNSVVRHRLTRLIRESYRLNEAEFENSLDIVVVARPQAKDRTYQEIESALMHLAGKHCIAGKNNDKEVSDQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174Q6K7</accession>
    <name>A0A174Q6K7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">kinA_1</name>
        <name evidence="7" type="synonym">kinA</name>
        <name evidence="7" type="ORF">ERS852478_00885</name>
        <name evidence="8" type="ORF">ERS852523_02460</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
            <strain evidence="8 10">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000026">
        <property type="protein sequence ID" value="CUP68942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706975.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000023_gene1781"/>
    <dbReference type="EnsemblBacteria" id="CUN72108">
        <property type="protein sequence ID" value="CUN72108"/>
        <property type="gene ID" value="ERS852478_00885"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP68942">
        <property type="protein sequence ID" value="CUP68942"/>
        <property type="gene ID" value="ERS852523_02460"/>
    </dbReference>
    <dbReference type="GeneID" id="66493011"/>
    <dbReference type="eggNOG" id="COG3852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN72108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP68942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="227" mass="25429" checksum="55E1928EAFCC20D2" modified="2016-09-07" version="1">MQIEITKQSEKDFRFLLSRLSHEIRNPVTLINSELQLMASSHPELCSYRQWDSLMDNLEYVKELLKELSDFSHAQTVTLVPVNPAEFLTTVLSCQKNTLDYLGIRLEIHVEHTSSPVFLDRIKMRQVIFNLIKNSCEAIDQPGGKIIVNLTPADSGICICIKDNGCGMTHKQTENIFHPFITYKPEGTGLGLAVTAEIISAHHGQIRVSSTPGQGSAFYIYLPASPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174S100</accession>
    <name>A0A174S100_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tetracycline resistance protein tetM from transposon Tn916</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Tetracycline resistance ribosomal protection protein Tet(O)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tetM</name>
        <name evidence="10" type="synonym">tet(O)</name>
        <name evidence="8" type="ORF">ERS852478_01261</name>
        <name evidence="9" type="ORF">ERS852523_03165</name>
        <name evidence="10" type="ORF">GT728_21500</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
            <strain evidence="9 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000041">
        <property type="protein sequence ID" value="CUP89135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000134">
        <property type="protein sequence ID" value="MZL35662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008399617.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000134.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87004">
        <property type="protein sequence ID" value="CUN87004"/>
        <property type="gene ID" value="ERS852478_01261"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP89135">
        <property type="protein sequence ID" value="CUP89135"/>
        <property type="gene ID" value="ERS852523_03165"/>
    </dbReference>
    <dbReference type="GeneID" id="67479024"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03711">
        <property type="entry name" value="Tet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035650">
        <property type="entry name" value="Tet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN87004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP89135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL35662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="639" mass="72255" checksum="FF5822117C11CC9B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174S537</accession>
    <name>A0A174S537_9FIRM</name>
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        <submittedName>
            <fullName evidence="11">DUF2179 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Uncharacterized BCR, YitT family COG1284</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852478_03016</name>
        <name evidence="10" type="ORF">ERS852523_03220</name>
        <name evidence="11" type="ORF">GT728_10145</name>
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    <organism evidence="10 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
            <strain evidence="10 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUP90535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZL33549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_WWVQ01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000010_gene2798"/>
    <dbReference type="EnsemblBacteria" id="CUO50299">
        <property type="protein sequence ID" value="CUO50299"/>
        <property type="gene ID" value="ERS852478_03016"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP90535">
        <property type="protein sequence ID" value="CUP90535"/>
        <property type="gene ID" value="ERS852523_03220"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
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        <property type="entry name" value="YitT"/>
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    </dbReference>
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        <property type="entry name" value="YitT_membrane"/>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="78"/>
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    </feature>
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        <location>
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            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="225"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO50299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP90535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL33549.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="287" mass="32241" checksum="31997552E6F58764" modified="2016-09-07" version="1">MKELNLKHEAKRYGCAVLAATIMALNIKTFVRAGGLFPGGFTGLTLLIQNIFQTFMGIAVPYTLINVLLNSIPVFIGLKFIGKKFTISSVCVIVLSGLLTDIIPSQPITYDTLLISIFGGLINGFCISLCLIGNTSTGGTDFIAIYFSEKNGRDIWNYILCGNAVILTVAGLLFGWDRALYSIIFQFTSTQVIQMLHQRYKKHTLFIITKEPYQIYEEIFKLTNHTATRFEGTGCYTDEKTSMIYSVVSTEEAKYLVKKVHEIDPKAFVNIIKTDYINGRFYQKTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SB90</accession>
    <name>A0A174SB90_9FIRM</name>
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        <submittedName>
            <fullName evidence="9">Molybdenum cofactor biosynthesis protein A</fullName>
        </submittedName>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
            <strain evidence="9 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CUP91719.1"/>
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        <property type="protein sequence ID" value="VUX66564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1121115.AXVN01000001_gene1147"/>
    <dbReference type="EnsemblBacteria" id="CUO30625">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04038">
        <property type="entry name" value="tatD_link_rSAM"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
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            <begin position="7"/>
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        </location>
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    </evidence>
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        </source>
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            <dbReference type="EMBL" id="CUO30625.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUP91719.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VUX66564.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="201" mass="23133" checksum="4A1A6565ED7E34A6" modified="2016-09-07" version="1">MTTDIIYRYKNQVYFNITNKCPCRCTFCIRNTEDAIGEASNLWFEHEPALEEIYKAIDEFDFSDCNEVVFCGYGEPTMALENLIAVSKYIRERYPFRIRLNTNGLSDLIHKRSTAEEICQAVDSISISLNMPDAASYNEVVRPAYGEKSFDAMLKFARDCKQYLDDVRFTVVDVIGEEKVEQSKILAAQNGIPLRVRKYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WY60</accession>
    <name>A0A173WY60_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">RutC family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">RutC family protein HI_0719</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_02590</name>
        <name evidence="2" type="ORF">ERS852478_00092</name>
        <name evidence="3" type="ORF">ERS852523_01911</name>
        <name evidence="5" type="ORF">GT712_01005</name>
        <name evidence="4" type="ORF">GT728_02985</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
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        <property type="protein sequence ID" value="CUN43477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUP52647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000005">
        <property type="protein sequence ID" value="MZL32184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZS87703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="VUX66218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703111.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1452"/>
    <dbReference type="EnsemblBacteria" id="CUN43477">
        <property type="protein sequence ID" value="CUN43477"/>
        <property type="gene ID" value="ERS852478_00092"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP52647">
        <property type="protein sequence ID" value="CUP52647"/>
        <property type="gene ID" value="ERS852523_01911"/>
    </dbReference>
    <dbReference type="GeneID" id="66495933"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN43477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP52647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS87703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="124" mass="13199" checksum="4A49FDF292280498" modified="2016-09-07" version="1">MKTLETKKAPAAIGPYSQAKMTGNFLFASGQIPVDPATGEVAGDKIETQAEQSCKNVGAILEEAGLTFDNVIKTTCFLADMADFAAFNAVYEKYFTSKPARSCVAVKQLPKNVLCEVEAIAVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X311</accession>
    <name>A0A173X311_9FIRM</name>
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        <submittedName>
            <fullName evidence="2">DUF2284 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Predicted metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02667</name>
        <name evidence="1" type="ORF">ERS852478_00169</name>
        <name evidence="3" type="ORF">GT712_00610</name>
        <name evidence="2" type="ORF">GT728_06145</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">BIOML-A1</strain>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381410.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45506">
        <property type="protein sequence ID" value="CUN45506"/>
        <property type="gene ID" value="ERS852478_00169"/>
    </dbReference>
    <dbReference type="GeneID" id="66495854"/>
    <dbReference type="eggNOG" id="COG5423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019271">
        <property type="entry name" value="DUF2284_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10050">
        <property type="entry name" value="DUF2284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN45506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL32797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS87627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="178" mass="20857" checksum="1A437B5E1C04A7D1" modified="2016-09-07" version="1">MNTEKFEEFISQYPIFEYRILDTKDITIQERVRTICQEECERYDSTWACPPAVGTLQECEKKIKSYPQAVFFSSVAEVSDIMNMEEMLSTRRAHEDLTTEVGKYLNKEGYETYILSTESCDICEKCAYKEGKPCRYPDRMHPCLESHGVVVNEIVERESMEYNLGGNTILWFSMVLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X5W9</accession>
    <name>A0A173X5W9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02723</name>
        <name evidence="1" type="ORF">ERS852478_00227</name>
        <name evidence="3" type="ORF">GT712_00330</name>
        <name evidence="2" type="ORF">GT728_05855</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">BIOML-A1</strain>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN47093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703324.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN47093">
        <property type="protein sequence ID" value="CUN47093"/>
        <property type="gene ID" value="ERS852478_00227"/>
    </dbReference>
    <dbReference type="GeneID" id="66495797"/>
    <dbReference type="eggNOG" id="ENOG5032Z1F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN47093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL32742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS87573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="79" mass="8760" checksum="5A20ED712C577B45" modified="2016-09-07" version="1">MNIGNNIGNIMKITGAWNTFKSNHPKFPAFCQAVSRKGLKEGSIIEIAITTPEGEKIETNLKVKDSDLELLKQLSDLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X7U4</accession>
    <name>A0A173X7U4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxybenzoyl-CoA reductase subunit alpha</fullName>
            <ecNumber evidence="2">1.3.7.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hcrA_2</name>
        <name evidence="2" type="ORF">ERS852478_00237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.7.9" evidence="2"/>
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        <property type="protein sequence ID" value="CUN47350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_JAAITO010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN47350">
        <property type="protein sequence ID" value="CUN47350"/>
        <property type="gene ID" value="ERS852478_00237"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
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        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
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        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
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        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ald_Xan_dh_C"/>
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        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="18"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN47350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="805" mass="87935" checksum="A47B26CE8D545C2E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XCE9</accession>
    <name>A0A173XCE9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulatory protein AsnC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">asnC</name>
        <name evidence="5" type="ORF">ERS852478_00270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380202.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49459">
        <property type="protein sequence ID" value="CUN49459"/>
        <property type="gene ID" value="ERS852478_00270"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_ARSR"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_HTH_AsnC-type_CS"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13404">
        <property type="entry name" value="HTH_AsnC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
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        <property type="entry name" value="HTH_ASNC"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF54909"/>
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    </dbReference>
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        <property type="entry name" value="HTH_ASNC_1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN49459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="152" mass="17238" checksum="852FB63E9DA17BBC" modified="2016-09-07" version="1">MYLDGLDELDQKIIRLLIENARISYSDIGEETGISRVAVKARIQALEKRGVIEEYTTIINPQKISGAVSCYFEIETKPEYLAQVTDILYKNDTVTQIYRVTGRDRLHIHAVASSGDEMEYFLHNVIDTLPGIISCSCNMILSRIKDIKGLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XJ04</accession>
    <name>A0A173XJ04_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-aspartate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yveA</name>
        <name evidence="6" type="ORF">ERS852478_00330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199570.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIOY010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51240">
        <property type="protein sequence ID" value="CUN51240"/>
        <property type="gene ID" value="ERS852478_00330"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN51240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="506" mass="54405" checksum="54011440208939F0" modified="2016-09-07" version="1">MEQKTSEFDKVLGAWDILVIAFGAMIGWGWVVSSGNWIESGGVLGAAIAFAIGGIMIFFVGLTYAELTAAMPQCGGEHVFSYRAMGSTGSFICTWAIILGYVSVACFEACAFPTIITYLWPGFLKGYLYTVAGFDVYASWLIVAIVIAFLIMIININGAKTAAVLQTVLTCIIGGAGIILIVASVVTGSVDNLQGQMFVGNGTGEAMKSIIKVAVITPFFFIGFDVIPQAAEEINVPLKKIGKMMILSVVLAVVFYSLVILAVGFILNPAEIIESQQGTGLVTADAMAKAFGTKVMAKVIIVGGMCGIITSWNSFLLGGSRAMYSMAESYMIPPFFAKLHPKHKTPVNSLYLIGALTMLAPFAGRTMMVWICDAGNFGCCLAYCMVSISFLILRKKEPDMARPYKVGYYKFVGFMAVVMSGLMLLVYCIPGSGGSLVFQEWIMVGGWSLLGVVFYAICKRKYKEDFGKLIELISDEDAASLMPEADDEELDVVIDAAIDRVLSSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XK39</accession>
    <name>A0A173XK39_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacteriophytochrome cph2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cph2_1</name>
        <name evidence="4" type="ORF">ERS852478_00353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199584.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52003">
        <property type="protein sequence ID" value="CUN52003"/>
        <property type="gene ID" value="ERS852478_00353"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
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            <begin position="157"/>
            <end position="178"/>
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        </location>
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            <begin position="227"/>
            <end position="246"/>
        </location>
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        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="415"/>
            <end position="546"/>
        </location>
    </feature>
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        <location>
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            <end position="861"/>
        </location>
    </feature>
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        <location>
            <begin position="870"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN52003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1126" mass="130536" checksum="1E40BA1FC75A5B78" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XQI9</accession>
    <name>A0A173XQI9_9FIRM</name>
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        <submittedName>
            <fullName evidence="4">Multidrug resistance protein MdtN</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">ERS852478_00420</name>
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        <name type="scientific">Blautia wexlerae</name>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="ERS852478_00420"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
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        <property type="entry name" value="Biotin_lipoyl_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
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        <location>
            <begin position="27"/>
            <end position="507"/>
        </location>
    </feature>
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        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
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        <location>
            <begin position="173"/>
            <end position="241"/>
        </location>
    </feature>
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        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN54004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="507" mass="55480" checksum="E4B43E1885E3DC0A" modified="2016-09-07" version="1">MKKIKLIKILAGFFALMLLFTFLSRAADSVNVAQVETKTAQNQVITHEVTGTGKVMGTRERAVFTQEGQKVEQVYVQEGQNVKKGDALLKFSVKYLKKTIKEKQDAIDVLQGKINDLISAESVNQQKRHNEFSDAQENYNSAVSSGNYSVQAAQNEAAIARQKLQDYYAQRDAAQNDVQDKIPDEEKFSDSSEFDDPGNTDDFGNTDDPENSDDSGNTDRPDGEGNKNTSGNGDNSNAQDNSQEQALIDDIRAKEEAVNEAMLSRRRELQSAEQAIRDTQIGDASDSTLENTQAELETAQKDLETLQKVLARKGKVKAPCDGVIKSLSAVTGSQTGAEAAVVLYESKGTFRFQAEVSKDDLKYIKSGGEVILKGADEKEITGAKVESVKEDSSNENQYILSVQVPEGTLSIGDTAEFTISQDAGPFNVCVPLSALYEENGRYYVYVTDTQNTVLGEVLVARKTYVNVKDKNSSTAALENGDLSSDQKIVTSSDREISSGSRIRLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XRB9</accession>
    <name>A0A173XRB9_9FIRM</name>
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    </gene>
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        <lineage>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="79"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="327" mass="37657" checksum="895D8B216ED73F93" modified="2016-09-07" version="1">MKVEMIQIKKRHFDVETDGFYGAYWKCKTGSDCAMIAMIGDDPEDYLARTSVKWLHKLGVNVMTMSSGKKDYGHHNYPLERIEKAINWLKAHGDQKIGIVGASTTGTLALTAASYFKDITLTIGLTPSDFIWQGFMQGKRDGCKEWPIDGESLFSYKGEPLPHMPFCYKHPDYWHVIEKETKRTGDMINSRKLFDDSEKAHPITEDEMIKIEKIHGTVLLIGAEDDVLWDTAKYIRRMKQRMKEHSHTCTLDYVIYEHGTHFVFPESMLKTMLPVGSGLFVKLAFQAAKKHPKECRRARLDIDWRVRNAVAKWKSASAKWKLNTCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XWR3</accession>
    <name>A0A173XWR3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Ig domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
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    <reference evidence="2 3" key="1">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199628.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54868">
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        <property type="gene ID" value="ERS852478_00448"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015721" evidence="1">
        <location>
            <begin position="28"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN54868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="893" mass="98827" checksum="048E7D1115E06E84" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YAX7</accession>
    <name>A0A173YAX7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_03269</name>
        <name evidence="1" type="ORF">ERS852478_00587</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Blautia</taxon>
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    <reference evidence="1 3" key="1">
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            <authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60165">
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        <property type="gene ID" value="ERS852478_00587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN60165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX66992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="30" mass="3381" checksum="21F6C91107F9A913" modified="2016-09-07" version="1">MTLLYVLIAARLDALMGTEYLRDKDSCCTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YCQ9</accession>
    <name>A0A173YCQ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706140.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60936">
        <property type="protein sequence ID" value="CUN60936"/>
        <property type="gene ID" value="ERS852478_00609"/>
    </dbReference>
    <dbReference type="GeneID" id="66492506"/>
    <dbReference type="eggNOG" id="ENOG502Z9W3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN60936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="365" mass="41115" checksum="DAE3C7889D1D5DE6" modified="2016-09-07" version="1">MTALLELKQRIKNLYSQYEIYILPVLRFVLAMVYFIWINTNMGYMKQIDNIFIVLILALICSILPSGVMIFVGFALMVAHGYALGIEVAGFMLVLILFMAILFLRFSSDNNLVLVFTPLSFGFSVPTLLPIGSGLLCNAFSALPAGCGVIIYYFIRFIRVQHKLLENPDVAIADKLKLLTDGIVQNWGMWITVIAFIAVILLVNLIRTRSFDYAWRIAIIAGGVVYVLMIIAGGFYFRLDIDVVTLIIYTVISVVIGLLLEFFVFGGDYTRTERLEYEDDEYYYYVKAVPKACVTTSERSIKKINGSSAKDERPAQDNVVSYANPIFHGDEKAVTTDEAAAPVERKKDIDSVDFEKKLEESLKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YE06</accession>
    <name>A0A173YE06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706125.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61235">
        <property type="protein sequence ID" value="CUN61235"/>
        <property type="gene ID" value="ERS852478_00618"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN61235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="320" mass="37818" checksum="CF55A2B2BCA4705F" modified="2016-09-07" version="1">MKEIGGYFQLEEMPGEEYYPDLYRVNLGRTALLWLLKSRRCRKILLPYFLCGSVVHTCQENQIETEFYHLNEKLEVLYPKEQLPEGEYLYLVNYYGQLSDSRISEYKKIYGNIIVDHTHAFFQKPLKGIDTLYSCRKFWGVSDGAYLSTDTSLTENKTVDYSAERMKHILGRYEHNAGTYYKDMLENAAKYDGMELRQMSKLTQNLLKAVDYDRAKKKREENYRILGELLPSESIFNQTVPEGPFAYPYFHADGMKLRRYLAEKKIFVPTYWKNIIENSETKSLEYTWAANILPLPCDQRYSVEDMKYMASVVRECEERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YF69</accession>
    <name>A0A173YF69_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative colanic biosynthesis UDP-glucose lipid carrier transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">wcaJ_1</name>
        <name evidence="9" type="ORF">ERS852478_00632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199726.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61776">
        <property type="protein sequence ID" value="CUN61776"/>
        <property type="gene ID" value="ERS852478_00632"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017473">
        <property type="entry name" value="Undecaprenyl-P_gluc_Ptfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03023">
        <property type="entry name" value="WcaJ_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="280"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN61776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="467" mass="54277" checksum="4EE104B812D69E63" modified="2016-09-07" version="1">MLKDNEKNFSRLHMIIDAIVLVLSYFLAWLIRFVGPMAATAVRTRSFQQYMLMLVFIVPVYLLLYQAFTLYTPMRMQGRRLVLANIVKANSLGLLILMFTFYMIDESDFSRSTYIMFYVINIVLQWCARMLIFALLRDMRERGLNQKQMICVGYSRAAEEYIDRVLANPQWGYVIRGILDDNVPAGTEYKGIKVLGRIANLNIILPENRLDEIAITLGLSEYYRLEEIVALCEKSGVHTKFIPDYNKIIPTKPYTEDILGLPVINIRYVPLNNTFNALVKRAMDIAGSIVGIIVTSPLMLLMCAIIKLTSPGPLIYKQERVGLHNQTFRMYKFRSMEVQPELEEKKAWTVKNDPRVTPIGKFMRHTSIDELPQLFNILKGNMSLVGPRPERPFFVEKFREEIPRYMVKHQVRPGLTGWAQVNGYRGDTSIRKRIEYDLYYIENWSIGLDIKIIFLTFFKGFINKNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YKF3</accession>
    <name>A0A173YKF3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Domain of uncharacterized function (DUF1836)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN63696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026649969.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPC010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63696">
        <property type="protein sequence ID" value="CUN63696"/>
        <property type="gene ID" value="ERS852478_00660"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014975">
        <property type="entry name" value="DUF1836"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40056">
        <property type="entry name" value="PTHR40056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08876">
        <property type="entry name" value="DUF1836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN63696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="205" mass="24338" checksum="A091191C4CDC8033" modified="2016-09-07" version="1">MTIDDKDMINSILESVSRIDYIKPEDIPNIDLYMDQVTTFMEEQLVSSKRYADDKILTKTMINNYAKNKLLPPPEKKRYSKEHVLMLIFIYYFKNILSINDIQTLLTPIAQKYFKSMTEKDMTYIYNEVFSMEKEQIESLKKDLLRKYKTAQDTFGDADEEDQANLKRFSFICLLSFDVYVKKMMIEHIIDGMNPESEHNSKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YPP0</accession>
    <name>A0A173YPP0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="6">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsmH_2</name>
        <name evidence="6 9" type="synonym">rsmH</name>
        <name evidence="10" type="synonym">rsmH_1</name>
        <name evidence="10" type="ORF">BWLFYP14_01798</name>
        <name evidence="7" type="ORF">ERS852478_00710</name>
        <name evidence="8" type="ORF">ERS852523_00634</name>
        <name evidence="9" type="ORF">GT728_03785</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
            <strain evidence="8 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP12634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706511.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000016_gene3655"/>
    <dbReference type="EnsemblBacteria" id="CUN65327">
        <property type="protein sequence ID" value="CUN65327"/>
        <property type="gene ID" value="ERS852478_00710"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12634">
        <property type="protein sequence ID" value="CUP12634"/>
        <property type="gene ID" value="ERS852523_00634"/>
    </dbReference>
    <dbReference type="GeneID" id="66493487"/>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="33"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN65327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP12634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL32337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX65022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="311" mass="35084" checksum="5ECC0F815CCC686F" modified="2016-09-07" version="1">MEFKHKSVLLEETIEGLDIKPDGIYVDGTLGGAGHAGEVCRKLSAKGRFIGIDQDQDAIIAASERLAPYKQATIIRSNYCYMVQELAARGIYKVDGILLDLGVSSYQLDNEERGFTYRVDAPLDMRMDQRQTQTAGDIVNGYEEKELYRIIRDYGEDKFAKNIAKHIVAARQVKPITTTGELTEIIRESIPMKMQVKSGHPAKRTFQAIRIELNRELDVLRDSLDGMIDILDDGGRLCIITFHSLEDRIVKTIFRKNENPCTCPSDFPVCVCGKKSKGKVITRKPILPGETEMEENPRSKSAKLRIFERVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YS40</accession>
    <name>A0A173YS40_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">mnmA</name>
        <name evidence="8" type="ORF">ERS852478_00756</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706462.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67002">
        <property type="protein sequence ID" value="CUN67002"/>
        <property type="gene ID" value="ERS852478_00756"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="306"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN67002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="360" mass="41092" checksum="91F064DE3E8BE1F8" modified="2016-09-07" version="1">MRKAIIAMSGGVDSSVAALLTKETGDECIGATMKLFHNEDIGVKREKTCCSLDDVEDARNVCYRMGIRYYVFNFSERFKEDVMDRFVDAYEHGSTPNPCIDCNRYLKFDKMFQRMRELEYDYIVTGHYARVEYDEEKNRYLLKKAVDDTKDQSYVLYMLTQEQLAHISLPLGGLRKTEVREIAEKHGFVNARKHDSQDICFVPDGDYAKFIEQYTGRKSIPGDFVDTEGNILGKHKGIIHYTLGQRRGLGIPAASRLYVCDISPKTNQVVLGNNEDLFHSELTATKVNLISCESLKEPMRLKAKIRYRHPEQEAVAWQTEDGVLHVRFDKPQRAITRGQAVVLYDGDIVVGGGVIENCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YXE8</accession>
    <name>A0A173YXE8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-2 transporter permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01721</name>
        <name evidence="2" type="ORF">ERS852478_00800</name>
        <name evidence="4" type="ORF">GT712_02765</name>
        <name evidence="3" type="ORF">GT728_12520</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000030">
        <property type="protein sequence ID" value="MZL34002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="VUX64867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_WWVQ01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68664">
        <property type="protein sequence ID" value="CUN68664"/>
        <property type="gene ID" value="ERS852478_00800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025699">
        <property type="entry name" value="ABC2_memb-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13346">
        <property type="entry name" value="ABC2_membrane_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN68664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="208" mass="24033" checksum="7AAE9FA68CEA4885" modified="2016-09-07" version="1">MKGLVFKDLLLMKKMNKKVIFVMYFFVIAISFFGENEVYSIMSSAFFSLFIGMHLMMTMTYDGLTSWKQYELTLPMSKYQIIFSKYLTSLLLVPISIMGTVIIYIIRYVVYHNFTLSQFGFSIAIAIALPVLWCSICLAIAQWFGYMSVQYVRMICTLLVIFFVSKISKDMKYVTQNLVKNPMLITIFALGIVVASYFVSVIGYSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z8E7</accession>
    <name>A0A173Z8E7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_03341</name>
        <name evidence="4" type="ORF">ERS852478_00899</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67064.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_002594230.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72514">
        <property type="protein sequence ID" value="CUN72514"/>
        <property type="gene ID" value="ERS852478_00899"/>
    </dbReference>
    <dbReference type="GeneID" id="61912438"/>
    <dbReference type="GeneID" id="66495695"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025378">
        <property type="entry name" value="DUF4368"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF14287">
        <property type="entry name" value="DUF4368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00239">
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    </dbReference>
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        <property type="entry name" value="Zn_ribbon_recom"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00857">
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    </dbReference>
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        <property type="entry name" value="SSF53041"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
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            <begin position="166"/>
            <end position="307"/>
        </location>
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        <location>
            <begin position="404"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN72514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX67064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="541" mass="62474" checksum="04C2CC200A740090" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZH68</accession>
    <name>A0A173ZH68_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in archaea</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_01362</name>
        <name evidence="2" type="ORF">ERS852478_00992</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199876.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75467">
        <property type="protein sequence ID" value="CUN75467"/>
        <property type="gene ID" value="ERS852478_00992"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN75467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX64357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="307" mass="34452" checksum="A6F4C6C04D1BE953" modified="2016-09-07" version="1">MLYIKSLEQAVPVFKALGSDIRIRLIQTLLEHQEMNMNELASSLGITNGALTSHVKKLEESGILAILPEHSGHGNQKVCRINVDKILVDIASNNDSPAEDSYSIDIPIGNYFNYSVYPTCGLSTTDNLIGEVDDPRYFAHPSHVDAKILWFGRGFIDYRIPNMLPPGQKIDRLTLSFEISSEAPGVNSDWPSDISFFLNNTKVGAWTSPGDFGDVHGMFTPDWWFPNWNQYGLLKMLVIDRHGTFIDGLKISDVNTQQLTFTSQDDMVFRFQVDEPSQNIGGLTLFGKDFGNYNQDINVKVHYTPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZUN8</accession>
    <name>A0A173ZUN8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Autolysin</fullName>
            <ecNumber evidence="4">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lytA_1</name>
        <name evidence="4" type="ORF">ERS852478_01101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.28" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380905.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80172">
        <property type="protein sequence ID" value="CUN80172"/>
        <property type="gene ID" value="ERS852478_01101"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031JZR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018337">
        <property type="entry name" value="Cell_wall/Cho-bd_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19127">
        <property type="entry name" value="Choline_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017172" evidence="2">
        <location>
            <begin position="29"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="165"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN80172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="268" mass="30724" checksum="949A0A5B849755DA" modified="2016-09-07" version="1">MKKLKVFSISAILIAICCSFLFSASVSAASKKRNKFDHKPSGNIYYYDENGHTVKGLVTIRGKKYYFNEKGIQQNGWQKIKGDYYFFQIRNGCYASMVTSQRVNGIYLTKSGKARYNSEEKRKLNLMVTANQVMRHVTKKNMSKPEKLWRCYLKAVSYGYGGTGNDYDFRYYYSNWDVSYAEDMFYRGHGDCFAFASAFAYLANAVGFEAKVISSGGHGWAEIKGEVCDPNWAKGTGHIERYYRMSYDLSGVDGRPYYRGNRAYVITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A2W0</accession>
    <name>A0A174A2W0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">xerD_1</name>
        <name evidence="10" type="synonym">xerC</name>
        <name evidence="16" type="synonym">xerD</name>
        <name evidence="17" type="synonym">xerD_3</name>
        <name evidence="17" type="ORF">BWLFYP14_03056</name>
        <name evidence="14" type="ORF">ERS852478_01178</name>
        <name evidence="15" type="ORF">ERS852523_00499</name>
        <name evidence="16" type="ORF">GT712_03655</name>
    </gene>
    <organism evidence="14 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">2789STDY5834863</strain>
            <strain evidence="15 19">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="16 21" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 21">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="17 20" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family. XerD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP08325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704075.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2124"/>
    <dbReference type="EnsemblBacteria" id="CUN82854">
        <property type="protein sequence ID" value="CUN82854"/>
        <property type="gene ID" value="ERS852478_01178"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08325">
        <property type="protein sequence ID" value="CUP08325"/>
        <property type="gene ID" value="ERS852523_00499"/>
    </dbReference>
    <dbReference type="GeneID" id="66494014"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011932">
        <property type="entry name" value="Recomb_XerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02225">
        <property type="entry name" value="recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0229">DNA integration</keyword>
    <keyword evidence="8 10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="13">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="12">
        <location>
            <begin position="106"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN82854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUP08325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZS88208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VUX66780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="294" mass="33986" checksum="4697634A7E42851F" modified="2016-09-07" version="1">MDIEIREFITYLHNTKKTSANTEISYQRDLKKMAEFLKERGIRNYKDVKELELEGYISYMEREKFASSSISRSVASMRAFFQYLWKEGVIAEDPADNLKPPKVEKRAPEILTIEEVDKLLQQPKLDTPKGIRDSAMLELLYATGMRVSEMLHLQIFDVNLQFGYVVCNENGKERIIPIGIPCKKAMERYLQTARTVFVKDEKETALFTNCSGKAMSRQGFWKVLKGYADDAGIKRDIAPHTLRHSFAVHMLQNGADIRSVQEMLGHSDISTTQVYLGMNMNKMRDVYMKTHPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A9Q9</accession>
    <name>A0A174A9Q9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Maltose transport system permease protein malF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">malF_2</name>
        <name evidence="8" type="ORF">ERS852478_01212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN84178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199964.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84178">
        <property type="protein sequence ID" value="CUN84178"/>
        <property type="gene ID" value="ERS852478_01212"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="73"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN84178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="317" mass="35930" checksum="3BDF2F2CA0A207C8" modified="2016-09-07" version="1">MKKKKSISYAKWGYIFILPFFVTFLIFSLIPLVDTVRYSFYEYYRSGIKEIGPNFIGIANYLSLLKSDMLKYSTNTLILWVIGFVPQIVIALVLACWFTDARLKIHGQQFFKVVIYLPNLIMASAFALLFFTMFSTNGPINSILMSLGWVKKPIDFLGSVIGTRSLVGFMNFLMWFGNTTIMLMAAVMGISMDIFEASELDGCNSIKRFFYITLPLIRPILAYTLITSIIGGLQMFDVPQILTNGQGNPDRTSMTLIMFLNSHLKSKNYGMAGALSVYLFIVSGILCMIVYKMTNDTDPDGSKKAAKKKAKEERRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AHA7</accession>
    <name>A0A174AHA7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugal transfer coupling protein TraG</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Type IV secretory system conjugative DNA transfer family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01257</name>
        <name evidence="4" type="ORF">GT728_16830</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VirD4/TraG family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000053">
        <property type="protein sequence ID" value="MZL34810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_007037036.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86878">
        <property type="protein sequence ID" value="CUN86878"/>
        <property type="gene ID" value="ERS852478_01257"/>
    </dbReference>
    <dbReference type="GeneID" id="61860933"/>
    <dbReference type="eggNOG" id="COG3505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003688">
        <property type="entry name" value="TraG/VirD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02534">
        <property type="entry name" value="T4SS-DNA_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN86878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="602" mass="68230" checksum="76753324307BEAF1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AIW3</accession>
    <name>A0A174AIW3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">groS</name>
        <name evidence="3" type="synonym">groES</name>
        <name evidence="9" type="ORF">BWLFYP14_01650</name>
        <name evidence="5" type="ORF">ERS852478_01310</name>
        <name evidence="6" type="ORF">ERS852523_00902</name>
        <name evidence="8" type="ORF">GT712_09455</name>
        <name evidence="7" type="ORF">GT728_08180</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000007">
        <property type="protein sequence ID" value="CUP20973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000015">
        <property type="protein sequence ID" value="MZL33177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705701.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000047_gene1263"/>
    <dbReference type="EnsemblBacteria" id="CUN88641">
        <property type="protein sequence ID" value="CUN88641"/>
        <property type="gene ID" value="ERS852478_01310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20973">
        <property type="protein sequence ID" value="CUP20973"/>
        <property type="gene ID" value="ERS852523_00902"/>
    </dbReference>
    <dbReference type="GeneID" id="66494932"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN88641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP20973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS89289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX64794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="94" mass="10042" checksum="C6471620A0212123" modified="2016-09-07" version="1">MTLVPLGDRVVLKQVEAEETTKSGIVLPGQAQEKPQQAEVVAVGPGGVVDGKEVKMEVAVGDKVIYSKYSGTEVKMDGTEYIIVKQNDILAIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AJU2</accession>
    <name>A0A174AJU2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oleate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_01623</name>
        <name evidence="2" type="ORF">ERS852478_01281</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.53" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87716">
        <property type="protein sequence ID" value="CUN87716"/>
        <property type="gene ID" value="ERS852478_01281"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050151">
        <property type="term" value="F:oleate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010354">
        <property type="entry name" value="Oleate_hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417">
        <property type="entry name" value="PTHR37417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06100">
        <property type="entry name" value="MCRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252524" evidence="1">
        <location>
            <begin position="24"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN87716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX64768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="658" mass="74364" checksum="71775598801E63D5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AKW5</accession>
    <name>A0A174AKW5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 15">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="8">IMP dehydrogenase</shortName>
            <shortName evidence="8">IMPD</shortName>
            <shortName evidence="8">IMPDH</shortName>
            <ecNumber evidence="8 15">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 17" type="primary">guaB</name>
        <name evidence="21" type="ORF">BWLFYP14_01647</name>
        <name evidence="17" type="ORF">ERS852478_01307</name>
        <name evidence="18" type="ORF">ERS852523_00899</name>
        <name evidence="20" type="ORF">GT712_09440</name>
        <name evidence="19" type="ORF">GT728_08195</name>
    </gene>
    <organism evidence="17 22">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 22 23" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 22">2789STDY5834863</strain>
            <strain evidence="18 23">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="19 25 26" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 26">BIOML-A1</strain>
            <strain evidence="20 25">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="21 24" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 15">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 14">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="8 15"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000007">
        <property type="protein sequence ID" value="CUP20898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000015">
        <property type="protein sequence ID" value="MZL33180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705695.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000047_gene1266"/>
    <dbReference type="EnsemblBacteria" id="CUN88529">
        <property type="protein sequence ID" value="CUN88529"/>
        <property type="gene ID" value="ERS852478_01307"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20898">
        <property type="protein sequence ID" value="CUP20898"/>
        <property type="gene ID" value="ERS852523_00899"/>
    </dbReference>
    <dbReference type="GeneID" id="66494935"/>
    <dbReference type="eggNOG" id="COG0516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 8 15" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11 15" id="KW-0520">NAD</keyword>
    <keyword evidence="6 8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 8 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 8 15" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="93"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8 10">
        <location>
            <begin position="336"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8 10">
        <location>
            <begin position="359"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="8 10">
        <location>
            <begin position="383"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="8 9">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="296"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 12">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 12">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 12">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUN88529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CUP20898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MZL33180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="MZS89286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="VUX64791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="485" mass="52220" checksum="C32B719BE97398EB" modified="2016-09-07" version="1">MGTIIGEGITFDDVLLVPAYSKVIPNQVDVTTYLTKKVKLNIPMMSAGMDTVTEHRMAIAMARQGGIGIIHKNMSIEAQAEEVDKVKRSENGVITDPFYLSPEHTLKDADELMAKFRISGVPITEGRKLVGIITNRDLKFETDFSKKIKECMTSEGLITAKEGITLEDAKKILAKSRKEKLPIVDDDFNLKGLITIKDIEKQIKYPLAAKDEQGRLLCGAAVGITANVLARVDALVKASVDVIVIDSAHGHSENILKAVREIKAAYPELQVIAGNVATGAATKALIEAGVDAVKVGIGPGSICTTRVVAGIGVPQITAVMDCYEAAKEYGIPIIADGGIKYSGDVTKAIAAGANVCMMGSMFAGCDESPGTFELYQGRKYKVYRGMGSIAAMENGSKDRYFQENAKKLVPEGVEGRVAYKGHVEDTVFQLMGGLRSGMGYCGAETIEKLKETGRFIKISAASLKESHPHDIHITKEAPNYSVDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AL62</accession>
    <name>A0A174AL62_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjO</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Lactose transport system permease protein LacF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjO_6</name>
        <name evidence="10" type="synonym">lacF_4</name>
        <name evidence="8" type="synonym">ycjO_2</name>
        <name evidence="10" type="ORF">BWLFYP14_01637</name>
        <name evidence="7" type="ORF">ERS852478_01295</name>
        <name evidence="8" type="ORF">ERS852523_00887</name>
        <name evidence="9" type="ORF">GT712_09385</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
            <strain evidence="8 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000007">
        <property type="protein sequence ID" value="CUP20657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705678.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000052_gene869"/>
    <dbReference type="EnsemblBacteria" id="CUN88188">
        <property type="protein sequence ID" value="CUN88188"/>
        <property type="gene ID" value="ERS852478_01295"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20657">
        <property type="protein sequence ID" value="CUP20657"/>
        <property type="gene ID" value="ERS852523_00887"/>
    </dbReference>
    <dbReference type="GeneID" id="66494946"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="78"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN88188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP20657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX64782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="300" mass="33209" checksum="10A11C1DAE30D23E" modified="2016-09-07" version="1">MNEKGISLVQLRQRKTRQTAALFLAPVIILLVVFIAYPIIDTFITSGYQWNGISADKKMVGLANWAKLIKDTKFWIAFKNNVIIMILSIIIQIPLGLAMATFLDFGGKKLTIFKVIWFIPMLMSSVAIGFLFTYALATNGGIVSTISGWFGGGNIDLLGNPKLALLTVILIIAWQFTPFYMVYFMAGYTNIPYDVFEAARIDGATRGQYFWKIALPLLIPSIKSAAILSMVGSLKYFDLIYVMTGGGPGTATELMATYMYKESFKNFNMGYGSAIAGGMFILITMVSMITMKLINGKQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AN23</accession>
    <name>A0A174AN23_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF2961)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200019.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89603">
        <property type="protein sequence ID" value="CUN89603"/>
        <property type="gene ID" value="ERS852478_01333"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021345">
        <property type="entry name" value="DUF2961"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11175">
        <property type="entry name" value="DUF2961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN89603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="369" mass="42324" checksum="27655AC99A4D4EBF" modified="2016-09-07" version="1">MYQSFKGGLGGIALSKHGRSRAINAENPHGEKGKGGMAASHLGPSRKGSPCLRDIEPGATVTLAEMEGPGEINHIWITVDNKTTDADCFVLRDLVIRMYWDDEETPSVESPLGDFFCCGFGRECIVNSVPMAVVPSRGFNCYFPMPFKKKAKITLENQHANKIPAFFYQVDYCLYDELPDDITYFHAQWRRERLTEKQKDYTILDGVKGKGHYVGTYIALTTLERYWWGEGEMKFYIDGDDEYPTICGTGTEDYFGGSWSFAKQVDGKTVEQNYNTPYLGYPYYSAHDELIHNFYHNDDCPPMRGFYRWHIQDPICFDEDLRVTIQQIGVGYRGLFERQDDVASVAYWYQTHPHAPFAPLMSKEDRWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AN91</accession>
    <name>A0A174AN91_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fructose-1,6-bisphosphatase class 3</fullName>
            <shortName evidence="2">FBPase class 3</shortName>
            <ecNumber evidence="2">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">fbp</name>
        <name evidence="3" type="ORF">ERS852478_01318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FBPase class 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579640.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88945">
        <property type="protein sequence ID" value="CUN88945"/>
        <property type="gene ID" value="ERS852478_01318"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01854">
        <property type="entry name" value="FBPase_class3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009164">
        <property type="entry name" value="FBPtase_class3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06874">
        <property type="entry name" value="FBPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000906">
        <property type="entry name" value="FBPtase_Bacill"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN88945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="651" mass="74722" checksum="2A4E5187007413AC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
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    <name>A0A174B1V1_9FIRM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
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            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200090.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94199">
        <property type="protein sequence ID" value="CUN94199"/>
        <property type="gene ID" value="ERS852478_01443"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032207">
        <property type="entry name" value="DUF5026"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16429">
        <property type="entry name" value="DUF5026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN94199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="94" mass="11309" checksum="87D2DFAF213EA4B8" modified="2016-09-07" version="1">MLINHIERIEFDMDEVRRGTLIYAKHRTWKEGMPGIVYHVSEERITVMFPNEKTNTQNHFFIPVSEVYKNEWEIRYSSDGLRTVQEYREAANES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B6U3</accession>
    <name>A0A174B6U3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ion-translocating oxidoreductase complex subunit G</fullName>
            <ecNumber evidence="6">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rnf electron transport complex subunit G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 12" type="primary">rnfG</name>
        <name evidence="12" type="ORF">BWLFYP14_00986</name>
        <name evidence="9" type="ORF">ERS852478_01492</name>
        <name evidence="11" type="ORF">GT712_13090</name>
        <name evidence="10" type="ORF">GT728_10965</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 16">BIOML-A1</strain>
            <strain evidence="11 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnfG family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000024">
        <property type="protein sequence ID" value="MZL33704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000026">
        <property type="protein sequence ID" value="MZS89981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704336.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95919">
        <property type="protein sequence ID" value="CUN95919"/>
        <property type="gene ID" value="ERS852478_01492"/>
    </dbReference>
    <dbReference type="GeneID" id="66492610"/>
    <dbReference type="eggNOG" id="COG4659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00479">
        <property type="entry name" value="RsxG_RnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010209">
        <property type="entry name" value="Ion_transpt_RnfG/RsxG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36118">
        <property type="entry name" value="PTHR36118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006091">
        <property type="entry name" value="E_trnsport_RnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01947">
        <property type="entry name" value="rnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033731562" description="Ion-translocating oxidoreductase complex subunit G" evidence="7">
        <location>
            <begin position="32"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="8">
        <location>
            <begin position="105"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="modified residue" description="FMN phosphoryl threonine" evidence="6">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN95919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL33704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS89981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX63500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="202" mass="21260" checksum="D4E4A5412B53DC11" modified="2016-09-07" version="1">MSNRIIKDTIAITVITLVAGLALGVVQDITADPIAKQEAQAKQDAYKAVFADADSFETVDVDADAMQSYLDENGYAAQSIDETMLAKDASGNELGYAFTVTTSEGYGGDIQFAMGIQDDGTLNGISILSIGETAGLGMRANTDAFKDQFKDKNVDKFEYTKTGATADDQIDALSGATITTNAMTNGVNAGLCAFQYEKGGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B904</accession>
    <name>A0A174B904_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_00964</name>
        <name evidence="2" type="ORF">ERS852478_01514</name>
        <name evidence="3" type="ORF">GT712_12980</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000026">
        <property type="protein sequence ID" value="MZS89960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993853.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96709">
        <property type="protein sequence ID" value="CUN96709"/>
        <property type="gene ID" value="ERS852478_01514"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN96709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS89960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX63478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="97" mass="11325" checksum="716EF3493DDCB48D" modified="2016-09-07" version="1">MYATKYYYEIDKWTVVDTAKSSGNDQNPSWPEPKLKDGQRTGAEEEHYFVTATYEKKKGKTETGRYEMDFSQWKELKKGEKIELKIDAAGFAEINQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BAM8</accession>
    <name>A0A174BAM8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase</fullName>
            <ecNumber evidence="3">2.7.1.49</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">thiD_1</name>
        <name evidence="3" type="ORF">ERS852478_01552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThiD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.49" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN98081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200142.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98081">
        <property type="protein sequence ID" value="CUN98081"/>
        <property type="gene ID" value="ERS852478_01552"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="2">
        <location>
            <begin position="11"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN98081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="267" mass="28502" checksum="5C4E1FD773D4B76C" modified="2016-09-07" version="1">MKKVLSIAGSDCSGGAGIQADLKTFSAHGVFGMSVIVSVVAENTSRVIDIQDITPDMIEKQIDAVFEDIEVDAVKIGMLSTPECMKAVAKKLLQYKPQNVVIDPVMYAKNGCPLMNPTAVSTLIDTVIPLADVLTPNIPEAEKIADMQISTVSDMEAAARKIYAMGCKAIVVKGGHHIGNAVDVLFNGENFYHFETSRIDTKNTHGTGCTFSSAIASQLAKGKSVPLAVESAKAYVTMAIEHSLAIGKGCGPTHHFYELYQHGLSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BCU0</accession>
    <name>A0A174BCU0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01537</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200131.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97610">
        <property type="protein sequence ID" value="CUN97610"/>
        <property type="gene ID" value="ERS852478_01537"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025378">
        <property type="entry name" value="DUF4368"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14287">
        <property type="entry name" value="DUF4368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="168"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="573"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="427"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN97610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="623" mass="72485" checksum="119F185D91A869A4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BDS2</accession>
    <name>A0A174BDS2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA strand transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mobA_2</name>
        <name evidence="5" type="ORF">ERS852478_01543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MobA/MobL family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97806">
        <property type="protein sequence ID" value="CUN97806"/>
        <property type="gene ID" value="ERS852478_01543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005053">
        <property type="entry name" value="MobA_MobL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03389">
        <property type="entry name" value="MobA_MobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0184">Conjugation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MobA_MobL" evidence="4">
        <location>
            <begin position="2"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="293"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN97806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="428" mass="49628" checksum="D2AE553447F16D77" modified="2016-09-07" version="1">MELYEKAGNAQLAREIDVALPIELSREEQIRLVREYCSSQFVSRGMCVDFAIHDTDSGNPHCHIMLTMRPLDERGAWAAKSKKEYDLDENGERIRLPSGRYKTHKIDLTGWNDKDNTLLWRKAWADFTNDFLERNGSPERIDHRSNAERGIDEIPTVHMGVAACQMEKKGIATEKGELNRSIQKTNRLIREIRAQIGKLKEWIADLFKARETAPEQPPQSPNLANLLMKYLSVQREKSRKYSQRWQQQHAADELKTIAAAVNYLSEHGISNLDELDASLSSVSDKAYSIREGMKTAEQRMKELQKLIENGENYLQYKPIHAELKKLKNGWTNKRDKYEEAHRAELTLWNAASRYLHANLTDIKTLPISKWKQEYADLKEQRDTDYTKLKATRAEVAELQKIRRCVDIALRADQPAQTQSRTKRHDIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BL51</accession>
    <name>A0A174BL51_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage transcriptional regulator, ArpU family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01634</name>
        <name evidence="2" type="ORF">ERS852523_02241</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000022">
        <property type="protein sequence ID" value="CUP62440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008688147.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01791">
        <property type="protein sequence ID" value="CUO01791"/>
        <property type="gene ID" value="ERS852478_01634"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP62440">
        <property type="protein sequence ID" value="CUP62440"/>
        <property type="gene ID" value="ERS852523_02241"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO01791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP62440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="190" mass="22389" checksum="3705ED3936BDDE8E" modified="2016-09-07" version="1">MTDRDYAIKSMKEITFQMASHAQDYLEVTIERHYTDIKELMTSYQKLILENQIVLEELDMECQEKINEDMAYALSYLSIYNNQLNVPKMHREMNNLMIIYGLSDMIYRGMTLVKFYAPNGVMLSEILHSCFCSHYNKTDVEVQQELGIGRTSFYKMKKQALGYLGFYFYEIVVPQAKDKRFKPSLGVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C135</accession>
    <name>A0A174C135_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-tagatose-1,6-bisphosphate aldolase subunit GatY</fullName>
            <ecNumber evidence="4">4.1.2.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gatY_1</name>
        <name evidence="4" type="ORF">ERS852478_01758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.40" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200228.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06643">
        <property type="protein sequence ID" value="CUO06643"/>
        <property type="gene ID" value="ERS852478_01758"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009025">
        <property type="term" value="F:tagatose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="209"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="230"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO06643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="283" mass="31541" checksum="149F3198715B03E4" modified="2016-09-07" version="1">MLEKVSTILKMADESNTAVISFICTDYNMVYSVVTTAEKTNTPALVMLLPEHYEKNNTMNVHGFAEMVKELAESVKVPIGLHLDHSYDYDSVITSIKKGFDSVMIDASAYSLDENIALTRKVTETAHILGADVEAEIGHVGLAQDCDGDKTDYYTKADAAARFYQETNVDSLAIAIGNAHGVYVETPHLDIQRLEEINAATDVPLVLHGGSGIPHDQLEIAFRKGINKFNVGTEFLSVYYDAVKEYVHMMEGNDKPLKMLEVPEFVQTRLCEYLEEKMKLSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C5F1</accession>
    <name>A0A174C5F1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromate transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Chromate transporter, chromate ion transporter (CHR) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_01820</name>
        <name evidence="9" type="ORF">GT728_18320</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000069">
        <property type="protein sequence ID" value="MZL35080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578007.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000069.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08642">
        <property type="protein sequence ID" value="CUO08642"/>
        <property type="gene ID" value="ERS852478_01820"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO08642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL35080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="191" mass="20959" checksum="A6C9A2EDDAD3911D" modified="2016-09-07" version="1">MEEKTKSKGYVLRKLFFACLYLSTFTFGGGYVIVTLLKEKFVDHYHWIEEDEMLDLVAIAQSSPGAIAVNGAIIVGYKLAGIPGMLVSVIGAIIPPMVILSVISVFYDAFCSNYYIAALLKGMTAGVGAVIMSVVYDMGKNVVKSKDWVNVVIMIISFCLSYFLNVNIIYIILLVAVFGMVRTIVKGGREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C5Z3</accession>
    <name>A0A174C5Z3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LPS biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200255.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07178">
        <property type="protein sequence ID" value="CUO07178"/>
        <property type="gene ID" value="ERS852478_01775"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032D71">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO07178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="386" mass="45658" checksum="C278E588A719E17E" modified="2016-09-07" version="1">MNKKQKVILSLLQEIDEICRRNKIEYYLSPRLTLCAVEGHPFPQNPMFGVVLMKTADMERFRLAVDEDPREKRALESMKSHKWFSGFYLRYTNTDTLCLNLDNTRDYAFPGIGVNIFPLRTPVASVKAERRLSRDENAWTELCHINYADRNFRSRVNRTIMRLQCMITGRQGQAAHLYDRLVRSCQQPGANKYILKRRKQTTIFPAEIFAESKRVTLEGAELQVPAKTAEYLTISYGKNYKDAKEPRYVTPIALVVSARVSYTQFWKESGNFEKYCKERMKNARKLARSRRHKDYFNECWDYVEFCGERMNLGVSYEKQKDYIKNLYKNEDYMTLERVFRPYFKMMQKSLQKNELFAEDEEIFDIYVDVLEKTGKTVQRSKIGTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C6S4</accession>
    <name>A0A174C6S4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cobalamin-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Methionine synthase</fullName>
            <ecNumber evidence="3">2.1.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">metH_2</name>
        <name evidence="4" type="synonym">metH_5</name>
        <name evidence="7" type="ORF">BWLFYP14_01200</name>
        <name evidence="3" type="ORF">ERS852478_01788</name>
        <name evidence="4" type="ORF">ERS852523_03627</name>
        <name evidence="6" type="ORF">GT712_11980</name>
        <name evidence="5" type="ORF">GT728_05630</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000057">
        <property type="protein sequence ID" value="CUQ01597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000009">
        <property type="protein sequence ID" value="MZL32699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705414.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000014_gene1247"/>
    <dbReference type="EnsemblBacteria" id="CUO07575">
        <property type="protein sequence ID" value="CUO07575"/>
        <property type="gene ID" value="ERS852478_01788"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ01597">
        <property type="protein sequence ID" value="CUQ01597"/>
        <property type="gene ID" value="ERS852523_03627"/>
    </dbReference>
    <dbReference type="GeneID" id="66493418"/>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="B12-binding N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="88"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO07575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUQ01597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL32699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS89771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX63841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="211" mass="21806" checksum="47483C4840B1B16F" modified="2016-09-07" version="1">MSKINEVAELVEKGKAKLVGPAVQEAIDEGDDPVAILNDGMISAMSVVGEKFKNGEIFVPEMLVAARAMKKGVEVLKPHLASGSTGALGKVIIATVSGDLHDIGKNLVAMMIESAGFEVIDLGVDVPAAKIIECYKENPDVKIIALSALLTTTMPALKETVEALNAADFRGNIKVMVGGAPITEAFAEEIGADGYSDDAASAASLAKKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C9Q4</accession>
    <name>A0A174C9Q4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transporter, chromate ion transporter (CHR) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_01819</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200304.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08610">
        <property type="protein sequence ID" value="CUO08610"/>
        <property type="gene ID" value="ERS852478_01819"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO08610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="189" mass="20304" checksum="5C893057BF803F73" modified="2016-09-07" version="1">MIYIQLFLSFLQVGALSFGGGYAAMPLIQEQVVNLHSWLSMSEFTNLITIAEMTPGPIAVNSATFVGMQIAGILGAIIATLGCILPSCIIVTLLAYVYMKYRNMSLLQGTLASLRPAVVSMIAKAGVTILISAFFIDGTVNLIRQNVCVEMIIFFVIALVLLRKFKINPILAMVLCGVANVVLSAVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C9U2</accession>
    <name>A0A174C9U2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Purine nucleotide synthesis repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purR_3</name>
        <name evidence="5" type="ORF">ERS852478_01814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200295.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08456">
        <property type="protein sequence ID" value="CUO08456"/>
        <property type="gene ID" value="ERS852478_01814"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO08456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="341" mass="38700" checksum="035497BC77521712" modified="2016-09-07" version="1">MESGRQKVTRKDVAREAGVSETIVSYVLNKNRYVKEEKRQRVLEVVEKLQYHPNNIARALHGKGSLQILFLAEELSSGYFSELVSQMSRDAYRRGYMISLCESQEEDEFVSQILSRQFDGLFVSASGVTDRELKLLVKSGIPMVLFLNREISCDLRDTVVVDTGLYEGSRECVKHLVKNGCRNFVYLDKTGKQCDRDIHWKGFFDQIKESEITFAQEQRISGCEDIKKLEKRLQLLLEKNPSVDAIVARYDNLAAVALSVAGRTGRKVPDDLMVTGFDNDFISNYVSPALTTVEIQKEEVAKSAMEALLSLIRHDGVDKKISFTARLVIRESTGKKCYCKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CG73</accession>
    <name>A0A174CG73_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">nrdR</name>
        <name evidence="13" type="ORF">BWLFYP14_02223</name>
        <name evidence="10" type="ORF">ERS852478_01906</name>
        <name evidence="12" type="ORF">GT712_17515</name>
        <name evidence="11" type="ORF">GT728_10805</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 17">BIOML-A1</strain>
            <strain evidence="12 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NrdR family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000023">
        <property type="protein sequence ID" value="MZL33675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000051">
        <property type="protein sequence ID" value="MZS90806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703527.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11967">
        <property type="protein sequence ID" value="CUO11967"/>
        <property type="gene ID" value="ERS852478_01906"/>
    </dbReference>
    <dbReference type="GeneID" id="66493888"/>
    <dbReference type="eggNOG" id="COG1327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ATP-cone" evidence="9">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO11967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL33675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS90806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX65858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="149" mass="17563" checksum="AA7DC689199B0DDB" modified="2016-09-07" version="1">MKCPFCNQDNTRVVDSRPVEDTNSIRRRRLCDACGRRFTTYEKVESIPLTVIKKDQNREQYNRSKIQSGILRACYKRPISIDKIEEMMDAIEGEIFNTEEKEISSTRIGEIVMEHLKDLDAVAYVRFASVYREFKDVSTFMDELKKFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CI47</accession>
    <name>A0A174CI47_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphocarrier protein HPr</fullName>
            <ecNumber evidence="2">2.7.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ptsH_1</name>
        <name evidence="4" type="synonym">ptsH_3</name>
        <name evidence="4" type="ORF">BWLFYP14_02202</name>
        <name evidence="2" type="ORF">ERS852478_01929</name>
        <name evidence="3" type="ORF">ERS852523_03248</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000043">
        <property type="protein sequence ID" value="CUP91360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019162036.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000004_gene1973"/>
    <dbReference type="EnsemblBacteria" id="CUO12804">
        <property type="protein sequence ID" value="CUO12804"/>
        <property type="gene ID" value="ERS852478_01929"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP91360">
        <property type="protein sequence ID" value="CUP91360"/>
        <property type="gene ID" value="ERS852523_03248"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO12804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP91360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="85" mass="9432" checksum="0216AAA6EAC736D9" modified="2016-09-07" version="1">MKEFKYVVTDNEGIHARPAGELVKLVKGFESTISIEKEGKKVDCRKLLALMGLGVKKGHEVTFTIEGADEEAAYEAVSKFMQENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CLN4</accession>
    <name>A0A174CLN4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">btrV</name>
        <name evidence="4" type="ORF">ERS852478_01922</name>
        <name evidence="6" type="ORF">GT712_17435</name>
        <name evidence="5" type="ORF">GT728_10725</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">BIOML-A1</strain>
            <strain evidence="6 8">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000023">
        <property type="protein sequence ID" value="MZL33659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000051">
        <property type="protein sequence ID" value="MZS90790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381312.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12615">
        <property type="protein sequence ID" value="CUO12615"/>
        <property type="gene ID" value="ERS852478_01922"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO12615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL33659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS90790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="100" mass="11198" checksum="A8FBB34003FBAF7F" modified="2016-09-07" version="1">MSLKIEKKNEGTKDTVFLTGRLDTATAPELDTFAEKELLNTQELVLDFTGLEYISSAGLRVILKMQKFMNVKGTMKLIHVSDIIQDVFDITGFADILSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CMP7</accession>
    <name>A0A174CMP7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ebgA</name>
        <name evidence="6" type="ORF">ERS852478_01943</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13200">
        <property type="protein sequence ID" value="CUO13200"/>
        <property type="gene ID" value="ERS852478_01943"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004199">
        <property type="entry name" value="B-gal_small/dom_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032312">
        <property type="entry name" value="LacZ_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02929">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16353">
        <property type="entry name" value="DUF4981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01038">
        <property type="entry name" value="Bgal_small_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bgal_small_N" evidence="5">
        <location>
            <begin position="156"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO13200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="429" mass="49289" checksum="673DB70B71341BC1" modified="2016-09-07" version="1">MDGLVYPDRTVHTGLLEYKNVYRPARVISYDKESGELVLHNYMDFDDLKDYVKISYELTQDGLVISKGKLPEVSAAPHSEGKINLKINVPESGKCYLKFIYHLKKELPLLDEDHILGFDEIEVSQKDAKCQLAEKWVEKTVTDSELQVSEDDTQIHIKGREFAYTIDRRTALFTEMKFAGREYLNHPMELNIWRAPTDNDMYIKSEWKKAHYDKAYTRAYTTEVVQGKHGVKITSHASVVAETVQKILDVTITWKIEAAGKIDADIAVTKDDEFPDLPRFGVRMFLDKKLSAARYFGMGPQESYCDKHQAASHGLYHANVDDLHEDYIRPQENGSHYDCEYVELNNSRYGIVVSAENAFSFNASYYTQEELEKKTHNYELTESDSVVFCVDYALNGIGSNSCGPVVLDQYRFDDVLFRFQFTLIPYVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CU83</accession>
    <name>A0A174CU83_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200489.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16753">
        <property type="protein sequence ID" value="CUO16753"/>
        <property type="gene ID" value="ERS852478_02031"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO16753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="592" mass="65295" checksum="E380FD0F7A9FEEBA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CWR6</accession>
    <name>A0A174CWR6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF554)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200527.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17664">
        <property type="protein sequence ID" value="CUO17664"/>
        <property type="gene ID" value="ERS852478_02060"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007563">
        <property type="entry name" value="DUF554"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36111">
        <property type="entry name" value="PTHR36111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04474">
        <property type="entry name" value="DUF554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO17664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="243" mass="25833" checksum="F69F67F347043206" modified="2016-09-07" version="1">MPIGIIINALSIVIGGILGALVGYKLSPKFKEDITLVFGVCSMGMGISTIGLMENMPAVIFSVVIGTGIGLAIHLGERINAGAGVMQRVIGKFIKNSNSELSEDEFMNTLVTIIVLFCASGTGIYGSIVSGMSGDHSVLISKSILDLFTAAIFACSLGMVVCMIAIPQVLIFLILFFAATAIFPLTTPGMINDFKACGGFLMLATGFRMVKLKNFPTADMIPAMVLIMPMSWFWVNYILPLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D0Q2</accession>
    <name>A0A174D0Q2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580323.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17909">
        <property type="protein sequence ID" value="CUO17909"/>
        <property type="gene ID" value="ERS852478_02068"/>
    </dbReference>
    <dbReference type="GeneID" id="66493742"/>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO17909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="196" mass="22849" checksum="F9A69DA46140237A" modified="2016-09-07" version="1">MKTITISRQYGSGGRHIAALLSEKMGVPCYDSKLLLKEAERHGISQEIINEFKGKTSLLYAIGVMMSEESQDKKRLTIPEKMFHAQKETVKRLAQEGPCIFVGRCADQILKDDNQLLRVYIYASDMEDRIKRIKKNKHISQREALDRIAYKDRQRRDYYNFYTGHEWGKMENYDICLNTSVLSEEECVELLMKLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D5W3</accession>
    <name>A0A174D5W3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20617">
        <property type="protein sequence ID" value="CUO20617"/>
        <property type="gene ID" value="ERS852478_02135"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO20617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="153" mass="17824" checksum="77E0106E4312BFF7" modified="2016-09-07" version="1">MEQNVPKFKRTTEAIADGTGESSKQIQRYIRLTELIPELLDLVDNKKLQFTVAVDISYIDKEVQEWIYEYISDTGFIKPKQIAALRNQLNDGPINQIQMLSIFNNCVMAKKVSRSLTFSEKKLTKYFPDDYTAKDMEQVIESLLEKWMQEQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D8V0</accession>
    <name>A0A174D8V0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Daunorubicin/doxorubicin resistance ATP-binding protein DrrA</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">drrA_1</name>
        <name evidence="6" type="ORF">ERS852478_02179</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200608.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21994">
        <property type="protein sequence ID" value="CUO21994"/>
        <property type="gene ID" value="ERS852478_02179"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="310"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO21994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="357" mass="40012" checksum="F7495DE64CF6EBF5" modified="2016-09-07" version="1">MIEVNNLVKRYGNHTAVDHLSFKIEKGKIYGFLGPNGAGKSTTMNMITGYIASTEGTVKIDGHDILEEPEAAKKCIGYLPEQPPVYFDMTVLEYMKFVADLKKIPKDKKTNMIEEIMDMVKISDMRNRLIKNLSKGYRQRVGLAEAIMGYPEVIILDEPTVGLDPKQIIEIRTLIKELKKKHTVILSSHILSEVSAVCDYVLIISHGKLVASDTPENLGKLAEGSNTLEMLIKGEKTQIRQALEGIEGVNSVTMEKDEKQNLWSVKVSTEEQNDIREKVFYKMSEINSPIYEMKSRKVSLEEIFLELTASDKPISADEVPNTPEDKDTDAGKSNETNVKQTSAEIPEEQNNDKGGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DCC0</accession>
    <name>A0A174DCC0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF based on E. rectale Gene description</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_02831</name>
        <name evidence="1" type="ORF">ERS852478_02170</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21685">
        <property type="protein sequence ID" value="CUO21685"/>
        <property type="gene ID" value="ERS852478_02170"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z916">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024541">
        <property type="entry name" value="DUF3881"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12997">
        <property type="entry name" value="DUF3881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO21685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX66456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="302" mass="34442" checksum="D984035401A57045" modified="2016-09-07" version="1">MEGELFQGGVLMHSYLRAVGFSRITKRSSIRQIITDVVETYDEKTVIENYPDGMFAEFSKNYGCDCGITVCGQYDENNVFYPDYYFPFFRGTGITTQESVVIERHADKESFAGACDDLRIGVTLIFYLQNAAEYLQQREKGNILPGGQPLTLSGLAREGKILFPVEKDKEAVKAERELTKNRNHLIAAARNGDEEAMESLTMEDMDTYSMISQRIVTDDIFSIVDSYFMPYGIECDQYSIMGEILDFMTFKNIITGEEICQLTLDCNDMQFDVCINKNDLLGEPKIGRRFKGIIWLQGQLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DES9</accession>
    <name>A0A174DES9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">GAR transformylase</fullName>
            <shortName evidence="2">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">purN</name>
        <name evidence="4" type="ORF">ERS852478_02225</name>
        <name evidence="5" type="ORF">ERS852523_02430</name>
        <name evidence="6" type="ORF">GT728_09370</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
            <strain evidence="5 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO23963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000025">
        <property type="protein sequence ID" value="CUP67935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000018">
        <property type="protein sequence ID" value="MZL33402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705482.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000042_gene3031"/>
    <dbReference type="EnsemblBacteria" id="CUO23963">
        <property type="protein sequence ID" value="CUO23963"/>
        <property type="gene ID" value="ERS852478_02225"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP67935">
        <property type="protein sequence ID" value="CUP67935"/>
        <property type="gene ID" value="ERS852523_02430"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="3">
        <location>
            <begin position="3"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO23963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP67935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL33402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="213" mass="23306" checksum="F9386954C5B11B3C" modified="2016-09-07" version="1">MLKVGVLVSGGGTNLQAILDAIDCGKITNAEVSLVISNNPKAYALERAKNHNIEAVCISPKQYESREEFHKTLLEKLKESGVELIVLAGFLVAIPPMIVEAYPNKIINIHPSLIPSFCGVGYYGLHVHEKALARGVRVTGATVHFVDTGTDTGPIILQKAVKIKSDDTPEVLQRRVMEKAEWKILPKAINLIANGKVKVVDGRVEIEEYDTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DEV5</accession>
    <name>A0A174DEV5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="6">DHOD</shortName>
            <shortName evidence="6">DHODase</shortName>
            <shortName evidence="6">DHOdehase</shortName>
            <ecNumber evidence="6">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">pyrD</name>
        <name evidence="8" type="ORF">ERS852478_02233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of dihydroorotate to orotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-dihydroorotate + A = AH2 + orotate</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="6">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705490.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24212">
        <property type="protein sequence ID" value="CUO24212"/>
        <property type="gene ID" value="ERS852478_02233"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004589">
        <property type="term" value="F:orotate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="5 6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="7">
        <location>
            <begin position="4"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="68"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="241"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="263"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO24212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="300" mass="31704" checksum="750397F327817065" modified="2016-09-07" version="1">MDMSVNIAGVEWKNPVTVASGTFGSGAEFADYVDINKLGAVTTKGVANVPWAGNPTPRVAEVYGGMMNAIGLQNPGIDLFCERDIPFLKQYDTKIIVNVCGHAPEEYLAVVERLADQPIDMMEINISCPNVNAGFLAFGQDAHHVEELTAQIKKIAKQPVIMKLTPNVTDITEIAKGAEAGGADAVSLINTLTGMKIDINRKTFALANKTGGVSGPIVKPIAVRMVYQVAQAVNIPIIGMGGISCAEDAIEFILAGASAVSVGTANFHNPAVTLEVIDGIEAYMKKNGFNSVKEMVGIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DIU0</accession>
    <name>A0A174DIU0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endosialidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01472</name>
        <name evidence="1" type="ORF">ERS852478_02220</name>
        <name evidence="2" type="ORF">ERS852523_02438</name>
        <name evidence="4" type="ORF">GT712_11595</name>
        <name evidence="3" type="ORF">GT728_21030</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO23820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000025">
        <property type="protein sequence ID" value="CUP68132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000115">
        <property type="protein sequence ID" value="MZL35578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000022">
        <property type="protein sequence ID" value="MZS89698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705473.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000115.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000042_gene3037"/>
    <dbReference type="EnsemblBacteria" id="CUO23820">
        <property type="protein sequence ID" value="CUO23820"/>
        <property type="gene ID" value="ERS852478_02220"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP68132">
        <property type="protein sequence ID" value="CUP68132"/>
        <property type="gene ID" value="ERS852523_02438"/>
    </dbReference>
    <dbReference type="GeneID" id="66495139"/>
    <dbReference type="eggNOG" id="ENOG5031JM9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO23820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP68132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL35578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="137" mass="15369" checksum="D36604DA0C7F67BC" modified="2016-09-07" version="1">MAVVKELIRTEENGAISFGDYELAQKSKLSDYQHQGDMYKVKTFKEITKLERNGMFVYESVPGTAVFNLTQSEAQMDFHVEGPEDAQITVEMEPDTEYEVFIEQASTGKMKTNLGGKLSFSVELGNAARVEVKIVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DPK1</accession>
    <name>A0A174DPK1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <ecNumber evidence="2">5.4.99.18</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purE_2</name>
        <name evidence="2" type="ORF">ERS852478_02293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.18" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993373.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26035">
        <property type="protein sequence ID" value="CUO26035"/>
        <property type="gene ID" value="ERS852478_02293"/>
    </dbReference>
    <dbReference type="GeneID" id="66494411"/>
    <dbReference type="eggNOG" id="COG1691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039476">
        <property type="entry name" value="P2CMN_synthase_LarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064">
        <property type="entry name" value="PTHR43064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="1">
        <location>
            <begin position="115"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO26035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="253" mass="27430" checksum="BF28A8826124F3E0" modified="2016-09-07" version="1">MTLQEILESVKSGSVSVEEAERILKKESYEEMGYAKLDTSRKARTGFAEVIYCSNKADEHLLNIFERLYREDGEVFGTRASQHQYELVKEKFPETEYDPISRILKVEKKDKKRIGKIAVCSAGTADIPVAEEAAQTAEYFGTNVERIYDVGVSGMHRLFSRLETIQSANCVIAVAGMEGALASVMGGLVSRPVIAVPTSVGYGASMHGLSALLTMINSCANGIAVVNIDNGYGAGYLATQINRLAAGTDEKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DRS6</accession>
    <name>A0A174DRS6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter ATP-binding protein YheS</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Uncharacterized ABC transporter ATP-binding protein YheS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yheS_3</name>
        <name evidence="10" type="synonym">yheS_2</name>
        <name evidence="10" type="ORF">BWLFYP14_02928</name>
        <name evidence="6" type="ORF">ERS852478_02347</name>
        <name evidence="7" type="ORF">ERS852523_01072</name>
        <name evidence="9" type="ORF">GT712_13810</name>
        <name evidence="8" type="ORF">GT728_07850</name>
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    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CUO28292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP26432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000014">
        <property type="protein sequence ID" value="MZL33119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000029">
        <property type="protein sequence ID" value="MZS90119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000072">
        <property type="protein sequence ID" value="VUX66652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704538.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1066"/>
    <dbReference type="EnsemblBacteria" id="CUO28292">
        <property type="protein sequence ID" value="CUO28292"/>
        <property type="gene ID" value="ERS852478_02347"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26432">
        <property type="protein sequence ID" value="CUP26432"/>
        <property type="gene ID" value="ERS852523_01072"/>
    </dbReference>
    <dbReference type="GeneID" id="66494235"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="320"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="357"/>
            <end position="364"/>
        </location>
        <ligand>
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        </ligand>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO28292.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZL33119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS90119.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VUX66652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="518" mass="58887" checksum="32BF00B0D015C326" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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    <gene>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR003439">
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    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
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    </dbReference>
    <dbReference type="Pfam" id="PF16326">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="217"/>
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    </feature>
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            <end position="498"/>
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            <end position="587"/>
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            <end position="43"/>
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        <ligand>
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            <end position="320"/>
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        <ligand>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO29039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="605" mass="68733" checksum="03F14831E4FC8640" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
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        </recommendedName>
    </protein>
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        <name evidence="9" type="ORF">BWLFYP14_02145</name>
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    <organism evidence="8 10">
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        <lineage>
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            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
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    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CABHOF010000039.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUO32647"/>
        <property type="gene ID" value="ERS852478_02475"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:phosphorelay sensor kinase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="86"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO32647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX65764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="292" mass="34143" checksum="9A2DA9588E2E935A" modified="2016-09-07" version="1">MTKGRDYYIYMFIDEQMAFASVFKNLLVVLLLYIFVAASVFAFRRRSNAQLLKIQMMQEEACKQKLLQEAQRADMANNAKTEFLQRMSHDIRTPINGIRGMIEVADYYKDDLKKQDECRRKIWDASGYLLELINEVLDMSKLESEEIVLENKDFDINRLLHEIREVIEKQVYERGISLSEKEYNLKYRYLNGSPVHLKRILMNIISNAVKYNKEKGEILLSYYETQVDNRHILFEFQCKDTGVGMSKEFQNHIFEPFTQETGGARSVYGGTGLGMPITKKLIEKMGGTIKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E5M2</accession>
    <name>A0A174E5M2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">sphR_1</name>
        <name evidence="12" type="synonym">sphR_2</name>
        <name evidence="12" type="ORF">BWLFYP14_02141</name>
        <name evidence="11" type="ORF">ERS852478_02479</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994002.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32747">
        <property type="protein sequence ID" value="CUO32747"/>
        <property type="gene ID" value="ERS852478_02479"/>
    </dbReference>
    <dbReference type="GeneID" id="66495227"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="133"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="133"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO32747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX65756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="232" mass="26904" checksum="D0C5B38C7CF8E9BE" modified="2016-09-07" version="1">MDNHILVVEDDAAIREGVRILLEGEGYIVQEAEDGYQCLKKVSDDIDLVILDIMMPGISGIKTCEEIRKISHVPVLFLTAKSQESDKLLGLMAGGDDYLVKPFSYAELLARVKALLRRYHVYSQTLQGEKTKEHWIEYGKVKVNTQCNEVFRNEKEISLREMEYRILLLMMENPKKVFSVKNLYESLWEEPFLYSSGNTVMVHIRRLRMKIEDDPQKPKMIQTVWGKGYRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E9N7</accession>
    <name>A0A174E9N7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpsB</name>
        <name evidence="7" type="ORF">ERS852478_02495</name>
        <name evidence="8" type="ORF">GT712_02380</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380890.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33179">
        <property type="protein sequence ID" value="CUO33179"/>
        <property type="gene ID" value="ERS852478_02495"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO33179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS87969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="247" mass="27403" checksum="2E989D3AC8912588" modified="2016-09-07" version="1">MSVISMKQLLEAGVHFGHQTRRWNPKMAPYIYTERNGIYIIDLQQSVGMVDDAYNAIADIVADGGSILFVGTKKQAQDAIKTEAERCGQFYVNERWLGGMLTNFKTIQSRIARLKEIEAMEADGTFDVLPKKEVIELKKELAKLQKNIGGIKEMKRLPDAIFIVDPKKERICVQEAHTLGIPLIGICDTNCDPEELDYVIPGNDDAIRAVKLIVSKMADAVIEAKQGTADVGGEIEAESEEFAATEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EG12</accession>
    <name>A0A174EG12_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoaspartyl dipeptidase</fullName>
            <ecNumber evidence="2">3.4.19.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">iadA</name>
        <name evidence="7" type="ORF">ERS852478_02568</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="2">Carboxylation allows a single lysine to coordinate two zinc ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M38 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35688">
        <property type="protein sequence ID" value="CUO35688"/>
        <property type="gene ID" value="ERS852478_02568"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008798">
        <property type="term" value="F:beta-aspartyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010229">
        <property type="entry name" value="Pept_M38_dipep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001238">
        <property type="entry name" value="IadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01975">
        <property type="entry name" value="isoAsp_dipep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="56"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="71"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001238-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001238-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001238-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO35688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="383" mass="41246" checksum="72639EFFE9E86D7F" modified="2016-09-07" version="1">MMKLIQNIDVYAPQHLGKKDVLIINDKIVKIKDAGSICADGFLSEAEMINGEGLLLTPGFIDCHVHVLGGGGEGGFANRTPEATMEGLTKFGVTTVVGCLGTDGIGRDMCALVAKTKGLNEQGMSAYCYTGSYQIPVHTLTDSIVKDIMMIQEIIGTGEIAISDHRSSQPTFEEFARVVADTRLGGVLSGKAGIVNVHLGDSPRCLDLIERVVDETEIPASQILPTHINRNEMLFGKSIEYALKGGAVDFTGNEDIDYWETICDEVRVCNGIKRMLDAGVNPDRMTISSDGQGSLPMYSSDGEFLGMGVGQSSCLLKEVKECVFKTKIPLEIAISTITSNPADILRLKGKGKVEEGYDADLCILDQELQLVEVIAKGNTVYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ETI7</accession>
    <name>A0A174ETI7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic-di-AMP phosphodiesterase</fullName>
            <ecNumber evidence="1">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_02733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'-&gt;5')-adenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="ChEBI" id="CHEBI:138171"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GdpP/PdeA phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200908.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41114">
        <property type="protein sequence ID" value="CUO41114"/>
        <property type="gene ID" value="ERS852478_02733"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106409">
        <property type="term" value="F:cyclic-di-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014528">
        <property type="entry name" value="GdpP/PdeA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026583">
        <property type="entry name" value="YybT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="202"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR026583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR026583-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO41114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="683" mass="76889" checksum="02E104F030E1D8E1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EX07</accession>
    <name>A0A174EX07_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dnaC_2</name>
        <name evidence="15" type="synonym">dnaB</name>
        <name evidence="17" type="ORF">BWLFYP14_00571</name>
        <name evidence="13" type="ORF">ERS852478_02731</name>
        <name evidence="14" type="ORF">ERS852523_02527</name>
        <name evidence="16" type="ORF">GT712_09830</name>
        <name evidence="15" type="ORF">GT728_09565</name>
    </gene>
    <organism evidence="13 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 18">2789STDY5834863</strain>
            <strain evidence="14 19">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="15 21 22" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 22">BIOML-A1</strain>
            <strain evidence="16 21">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="17 20" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 11"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000027">
        <property type="protein sequence ID" value="CUP70602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000019">
        <property type="protein sequence ID" value="MZL33439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000017">
        <property type="protein sequence ID" value="MZS89361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707914.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000058_gene2543"/>
    <dbReference type="EnsemblBacteria" id="CUO41049">
        <property type="protein sequence ID" value="CUO41049"/>
        <property type="gene ID" value="ERS852478_02731"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP70602">
        <property type="protein sequence ID" value="CUP70602"/>
        <property type="gene ID" value="ERS852523_02527"/>
    </dbReference>
    <dbReference type="GeneID" id="66493317"/>
    <dbReference type="eggNOG" id="COG0305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0639">Primosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="12">
        <location>
            <begin position="179"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO41049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUP70602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL33439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZS89361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VUX62793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="442" mass="50106" checksum="C82A4C30436D1512" modified="2016-09-07" version="1">MEEALIKRILPHSIEAEQSVIGSMILDRDAILVASEILTSDDFYQKQYGIIFDAMVELCNEGKPVDLVTLQNRLKEKELPPDISSMEYVRDLISAVPTSANVKYYAKIVSEKAVLRRLIKANEEIANTCYLEKENTEIILEEAEKKLFNILQRRNNEEYVPIQQVVLNAINNIEKASKLKGSVTGIPTGFMDLDYKTSGMHPSDLVLIAARPSMGKTAFVLNIAQYMAFRKDVTVAIFSLEMSKEQLVNRLLAMESHVDSQNMRTGNLKDEDWTKLVEGADIIGKSNLIIDDTPGISIAEMRSKCRKYKLEHNLGIIMIDYLQLMSGSGKSDSRQQEISDISRSLKALARELNVPVIALSQLSRAVEQRPDHRPMLSDLRESGAIEQDADVVMFIYRDDYYHKDTEKKDIAEIIIAKQRNGPIGTVELVWLPRYTQFVNMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EY81</accession>
    <name>A0A174EY81_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galactose/methyl galactoside import ATP-binding protein MglA</fullName>
            <ecNumber evidence="5">3.6.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mglA</name>
        <name evidence="6" type="synonym">mglA_1</name>
        <name evidence="6" type="ORF">BWLFYP14_00575</name>
        <name evidence="5" type="ORF">ERS852478_02727</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.17" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058393.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40955">
        <property type="protein sequence ID" value="CUO40955"/>
        <property type="gene ID" value="ERS852478_02727"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="253"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO40955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX62797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="511" mass="55932" checksum="DE9E324B2B65E05F" modified="2016-09-07" version="1">MGENYALELRDISKSFGSVQANDHVDLTLRKSEILAILGENGSGKTTLMNMIYGIYYPDEGHIFVNGKEVTIRSPKDSYELGIGMVHQHFKLVDVLTAAENIVLGLPGKGKLDMKRITEDIQKLADKYGFELDLSQKIYEMSVSQKQTVEIIKMLYRGARILILDEPTAVLTPQESDRLFDILRNMRKDGCSIMIITHKLQEVLALSDRVAILRKGKYIDTVETAQANAQSLSEMMVGGRVDLNIDRPEPENVKKRLVVKGLNCKNKEEVKTLDDVDLTVNAGEILGIAGISGSGQKEFLEAIAGLQAIESGSITLLDDNGKGTELAGMDSISINKAGISLAFVPEDRIGMGLVGDMDMTDNMMLRSYRNGKSPFLDRKGPKALALKIKEQLEVMTPSISAPVRQMSGGNVQKVLVGREIAQNPKVLLVAFPTRGVDVNTSHVIYRLLNEQKKKGVAVVCVIEDLDVVLELCDRIAVFCGGKISGIEDGRTATKEGIGILMTKHEKGGTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F2K2</accession>
    <name>A0A174F2K2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transposase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BWLFYP14_00368</name>
        <name evidence="7" type="ORF">ERS852478_02769</name>
        <name evidence="8" type="ORF">ERS852523_02704</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
            <strain evidence="8 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000030">
        <property type="protein sequence ID" value="CUP75653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000026_gene1015"/>
    <dbReference type="EnsemblBacteria" id="CUO42510">
        <property type="protein sequence ID" value="CUO42510"/>
        <property type="gene ID" value="ERS852478_02769"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP75653">
        <property type="protein sequence ID" value="CUP75653"/>
        <property type="gene ID" value="ERS852523_02704"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="92"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="215"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO42510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP75653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX67523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="291" mass="34151" checksum="BFB03ED93F09519A" modified="2016-09-07" version="1">MEKAYKNFFRDPKVGFPRFKSKHHSKNSYTTNVVNGNILVEDKRIRLPKLKWISMKKHREPAENCCLKSVTVSMEPSGKYFASLLYEGYSCENQAADEDYSNAKILGIDYAMQGMAVFSEEIELEKAGFFRRNEKRLAREQRKLSRCVKESRNYVRQKKKVARCHEKIRNQRKDYLHKLSRRITDQYDIVAVEDIDMKAMGQCLHFGKSVQDNGYGMFRNMLDYKLAWKGKKLVKIDRFFPSSKKCSKCGKIKKELGLSERVYRCTCGNEMDRDRNAAINIREEARRMLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F2V0</accession>
    <name>A0A174F2V0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ydiB</name>
        <name evidence="7" type="synonym">tsaE</name>
        <name evidence="9" type="ORF">BWLFYP14_02882</name>
        <name evidence="5" type="ORF">ERS852478_02835</name>
        <name evidence="6" type="ORF">ERS852523_03591</name>
        <name evidence="8" type="ORF">GT712_17615</name>
        <name evidence="7" type="ORF">GT728_14495</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000056">
        <property type="protein sequence ID" value="CUQ00643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000038">
        <property type="protein sequence ID" value="MZL34376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000052">
        <property type="protein sequence ID" value="MZS90826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000064">
        <property type="protein sequence ID" value="VUX66505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705880.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000066_gene3223"/>
    <dbReference type="EnsemblBacteria" id="CUO44553">
        <property type="protein sequence ID" value="CUO44553"/>
        <property type="gene ID" value="ERS852478_02835"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ00643">
        <property type="protein sequence ID" value="CUQ00643"/>
        <property type="gene ID" value="ERS852523_03591"/>
    </dbReference>
    <dbReference type="GeneID" id="66494774"/>
    <dbReference type="eggNOG" id="COG0802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO44553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUQ00643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL34376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS90826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="144" mass="16201" checksum="6037535300795BD4" modified="2016-09-07" version="1">MIIETKTPQETFEVGKKIGENAKPGQIYTLTGDLGVGKTVFTQGVAAGLGITEPICSPTFTIIQEYESGRLPLYHFDVYRIGDIEEMEEIGYDDYFFGQGICLIEWADLIEEILPEKLIKVTIEKDLEKGFDYRRITVIGPENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F629</accession>
    <name>A0A174F629_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fumarate reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ifcA</name>
        <name evidence="5" type="ORF">ERS852478_02817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43800">
        <property type="protein sequence ID" value="CUO43800"/>
        <property type="gene ID" value="ERS852478_02817"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="4">
        <location>
            <begin position="441"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO43800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="572" mass="62761" checksum="A5BD51F7DE9A55EC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F6Y4</accession>
    <name>A0A174F6Y4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vitamin B12 import system permease protein BtuC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">btuC_2</name>
        <name evidence="8" type="ORF">ERS852478_02868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_044952338.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000067.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45451">
        <property type="protein sequence ID" value="CUO45451"/>
        <property type="gene ID" value="ERS852478_02868"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO45451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="344" mass="36337" checksum="88524A45795CEAC1" modified="2016-09-07" version="1">MYVAVLIGLAAFLIFSILAAITFGNADLSLKDVYSVIAYKLFHIKSLSAYAEGAVHDVVWLIRLPRVLLALAVGMALSVCGVVMQAIVQNPLADPYVLGISSGASLGATLAIMLGVGGFLGGNSVGVPAFIGAMVTSFAVIAIANMGGKATSAKLILAGMAVSAVCSAFSNFVIYITNDKNAATEVMKWTMGSLAGASWSRVGVMLPVTLICVIIFWTQYRNLNLMLLGDDVSITLGTDLHRLRTFYLIVASVMIGFAVYCAGVIGFVGLVIPHVIRILFGTDHRRLLPLSALLGASFLIWCDVACRVILKNSEMPIGVLVSIIGAPCFIYLLVRKSYGFGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F8B0</accession>
    <name>A0A174F8B0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">phoP_3</name>
        <name evidence="11" type="ORF">ERS852478_02861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200972.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45188">
        <property type="protein sequence ID" value="CUO45188"/>
        <property type="gene ID" value="ERS852478_02861"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO45188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="222" mass="25512" checksum="5C58726BCACEC202" modified="2016-09-07" version="1">MIYCVEDERNIRELLIYTLETTGFKARGVGNGNELMKALKEEIPELILLDIMLPGDDGYTILEQLKSMPSVKDVPVIMVTAKEAEFDKVKGLEGGADDYITKPFGMMEFVARVKAVLRRSARQNEDKELHYDELYLNVGRHEVHYREEKVDLTRKEFELLQYLLENKGLVMTRNQILCHVWGYDFDGETRTVDVHVRTLRQKLGEAGNLIETVRGVGYRIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FG34</accession>
    <name>A0A174FG34_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="9">RNAP subunit beta'</shortName>
            <ecNumber evidence="9">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">rpoC</name>
        <name evidence="13" type="ORF">ERS852478_02933</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9 10">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47370.1"/>
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                <person name="Groussin M."/>
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    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000043">
        <property type="protein sequence ID" value="MZL34527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000035">
        <property type="protein sequence ID" value="MZS90353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379952.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51693">
        <property type="protein sequence ID" value="CUO51693"/>
        <property type="gene ID" value="ERS852478_03052"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50330Y9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO51693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL34527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="77" mass="8591" checksum="715F2DD104051D2C" modified="2016-09-07" version="1">MKVSNIKDIDKFFSVVDSCEGRVELVTGEGDRLNLKSKLSQYVSLANIFSGGEIPELEIVAYEKDDIDKLMSFMING</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G743</accession>
    <name>A0A174G743_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-hydroxyglutaryl-CoA dehydratase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">2-hydroxyglutaryl-CoA dehydratase component A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hgdC_2</name>
        <name evidence="5" type="ORF">ERS852478_03205</name>
        <name evidence="6" type="ORF">GT712_14595</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000032">
        <property type="protein sequence ID" value="MZS90265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201234.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56740">
        <property type="protein sequence ID" value="CUO56740"/>
        <property type="gene ID" value="ERS852478_03205"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1924">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018709">
        <property type="entry name" value="CoA_activase_DUF2229"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09989">
        <property type="entry name" value="DUF2229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="3">
        <location>
            <begin position="6"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="BcrAD_BadFG" evidence="3">
        <location>
            <begin position="321"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2229" evidence="4">
        <location>
            <begin position="670"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO56740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS90265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="1414" mass="156904" checksum="C0EE3663F45E4432" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GAR7</accession>
    <name>A0A174GAR7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mepA_15</name>
        <name evidence="6" type="ORF">ERS852478_03276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO58991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580257.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58991">
        <property type="protein sequence ID" value="CUO58991"/>
        <property type="gene ID" value="ERS852478_03276"/>
    </dbReference>
    <dbReference type="GeneID" id="66495395"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO58991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="455" mass="49644" checksum="362441EECB6BAF0B" modified="2016-09-07" version="1">MKRIDFENGTVTNNILSAALPMLVAQILNLLYNIVDRIYIARIHDIGTTALGAVGLCFPIIMIITAFSNLFGSGGAPIFSINRGKGDSRTADMIMNTAFTMLCGSAAVLMLIGFLFARPLLTLFGASDDALVYAYPYLMIYLLGTLPSMIATGMNPFINAQGYAIIGMLSVTVGAVTNIILDPIFIFVLDMGIKGAAIATVISQILSALLVFYFLHGKSELKVRWIHINEISECTRHARDIISLGSAGFIMQLTNSLVSICCNNVLSVTGGDIYISVMTIISSVRQMVETPIHAINEGTSPVLSYNYGARRPDRVKKAGVVLIIMVLIYTGIMWSVILIAPEFLIGIFSSDKLLLKDAVPALKLYFAAFIFMDLQYIGQTVFKSLNKKKQAIFFSLLRKVFIVVPLTYFLPYGLHMGTDGVFMAEPVSNVIGGSLCFITMLVTILPELNKMGNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GBP6</accession>
    <name>A0A174GBP6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine ECF transporter S component ThiT</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Thiamine transporter ThiT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiT</name>
        <name evidence="3" type="ORF">BWLFYP14_03476</name>
        <name evidence="2" type="ORF">ERS852478_03258</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO58548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705130.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000055.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58548">
        <property type="protein sequence ID" value="CUO58548"/>
        <property type="gene ID" value="ERS852478_03258"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015234">
        <property type="term" value="F:thiamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012651">
        <property type="entry name" value="Thia_Transptr_ThiT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09515">
        <property type="entry name" value="Thia_YuaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX67201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="221" mass="24108" checksum="1289D9CEEF84F4E4" modified="2016-09-07" version="1">MFGFMVTADGGLTTAGYVITVIAGIILFFLAIYFAGKNSDKKKLTTRQLVFCAVAIALAFITSYLKIFKLPWGGSVTLCSMLFIVLIANWYGVGTGIMAGFAYGILQFIQEPYILSFFQVCCDYILAFAALGLAGLFAKQSHGLLKGYIIAVIARGAFHSLGGYLYWMSYMPDNFPKSLTAVYPILYNYSYLLAEGIITVIIISVPAVSKALIQVKRAALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GGL0</accession>
    <name>A0A174GGL0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted AAA-ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201310.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61702">
        <property type="protein sequence ID" value="CUO61702"/>
        <property type="gene ID" value="ERS852478_03353"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018631">
        <property type="entry name" value="AAA-ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012547">
        <property type="entry name" value="PDDEXK_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09820">
        <property type="entry name" value="AAA-ATPase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08011">
        <property type="entry name" value="PDDEXK_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA-ATPase_like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO61702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="531" mass="61330" checksum="C05820E95F56E8D5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GH02</accession>
    <name>A0A174GH02_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61633">
        <property type="protein sequence ID" value="CUO61633"/>
        <property type="gene ID" value="ERS852478_03350"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032ZWT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO61633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="162" mass="19162" checksum="F860463D996ED849" modified="2016-09-07" version="1">MNFNYCYKITYESGETYDRRRNELSVEISKEDYKKIITGVLQERSIDQIEGISDVIDKMTENVEFADRFMNKNGSLRKTPLKKKRAISKLEFFIPEYEYRRLKKMKNPIETLERPVEHMTVYRNDGSSVTLTAENGRVSIVDSREKNVRHIIEADHFISKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GJG7</accession>
    <name>A0A174GJG7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61517">
        <property type="protein sequence ID" value="CUO61517"/>
        <property type="gene ID" value="ERS852478_03345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO61517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="399" mass="45928" checksum="9B13FA693CDF4FA4" modified="2016-09-07" version="1">MWEFRKITAIEEPVFNNVLERFYNLGLDGLVRENIQNSLDGKLQESNLPVEVRIKTGNIPVSEIPGIEEIKKHIESLRGENSYTKETIAHMKKEMKKEIVPFISFEDSNTKGLSGAEHGEDFQEGDTWGVYAYKKGVHFMENDVELEKTRGGSHGVGKIACNAASDIHMMFFANCDADGRQHIGGTTQLIEHNLDGVNYRASGYFTRIKDDKYFPFENHFASMFRKDTRGLKIIIPYLRTQYIGENKAICSVCDNFFVAILQKKLVVYVNDYEINDETIHEIVSDPKFYPEQNPAEMKSCFTPLYINTYLEKDPILIQIADKNTEYKFKLYLQYEEEIKRARVAIVRGIGMKIEDKKIKGYVNSPFNGVLIPISSEEDIFLNLWKMNHTQVCLVIILKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GXW2</accession>
    <name>A0A174GXW2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yycF_4</name>
        <name evidence="9" type="ORF">ERS852478_03543</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201424.1">
        <property type="nucleotide sequence ID" value="NZ_WWVN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67582">
        <property type="protein sequence ID" value="CUO67582"/>
        <property type="gene ID" value="ERS852478_03543"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO67582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="224" mass="26463" checksum="B6AFEE6386558FB7" modified="2016-09-07" version="1">MKYKILVVDDDKELVKMLCSYFNMKQYETITATDGMEALNKIKMKPDIILLDINMPRMDGIEVCRLIRSKVLCPILFLTARVDEDDKINGLLSGGDDYITKPFSLRELEARIVTNIKREERHQQKTEYRFMDEMLMDYSEKIVAIAGHRIEFTKIEYQIIEFLSMHPGQVFDKERIYAQVCGYDAEGDSRTITELVRRIRKKIADYSEKEYIETVWGIGYRWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GY80</accession>
    <name>A0A174GY80_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage transcriptional regulator, ArpU family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02342</name>
        <name evidence="1" type="ORF">ERS852478_03473</name>
        <name evidence="3" type="ORF">GT712_16565</name>
        <name evidence="2" type="ORF">GT728_16090</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">BIOML-A1</strain>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708199.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65455">
        <property type="protein sequence ID" value="CUO65455"/>
        <property type="gene ID" value="ERS852478_03473"/>
    </dbReference>
    <dbReference type="GeneID" id="66493934"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO65455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL34672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="190" mass="22430" checksum="EDDB2491F1069C4D" modified="2016-09-07" version="1">MTDRDYAIKSMKEITFQMASHAQDYLEVTIERHYTDIKELMRSYQKLILENQVVLEELDMECQEKINEDMAYALSYLSIYNNQLNVPKMHREMNNLMIIYGLSDMIYRGMTLVKFYAPNGVMLSEILHSCFCSHYNKTDVEVQQELGIGRTSFYKMKKQALGYLGFYFYEIVVPQAKDKRFKPSLGVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZ77</accession>
    <name>A0A174GZ77_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Global nitrogen regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ntcA</name>
        <name evidence="4" type="synonym">ntcA_2</name>
        <name evidence="4" type="ORF">BWLFYP14_02357</name>
        <name evidence="3" type="ORF">ERS852478_03487</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65855">
        <property type="protein sequence ID" value="CUO65855"/>
        <property type="gene ID" value="ERS852478_03487"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="2">
        <location>
            <begin position="145"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO65855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="219" mass="25250" checksum="0AE8657DCAE52189" modified="2016-09-07" version="1">MNFENCFPLWNDLNTTQKKIISDNLITQYVKKGTIIHNGNLDCTGLLLVKSGQLRTYILSDEGREITLYRLFDMDMCLLSASCIIRSIQFEVTIEAEKDTDLWIIPAEIYKGIMKESAPVANYTNELIATRFSDVMWLIEQIMWKSLDKRVASFLLEETSIEGTNELKITHETIANHLGSHREVITRMLRYFQGEGLVKLSRGKITILDPKRLETLQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H0K0</accession>
    <name>A0A174H0K0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposon Tn7 transposition protein tnsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tnsB</name>
        <name evidence="3" type="ORF">ERS852478_03577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201447.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68552">
        <property type="protein sequence ID" value="CUO68552"/>
        <property type="gene ID" value="ERS852478_03577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015378">
        <property type="entry name" value="Transposase-like_Mu_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09299">
        <property type="entry name" value="Mu-transpos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="222"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO68552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="613" mass="70966" checksum="6635E69305B17141" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H337</accession>
    <name>A0A174H337_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201457.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69263">
        <property type="protein sequence ID" value="CUO69263"/>
        <property type="gene ID" value="ERS852478_03596"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="86" mass="9809" checksum="E8A75D096DE8EEC6" modified="2016-09-07" version="1">MELTPTLILNLALLIVPPVAIGLVFRQWLARHIRWTVALTALCDVLLFWDELFYYESFGLFAVLILVQLAATGAAAFRIYNKQKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HNX0</accession>
    <name>A0A174HNX0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">8-oxo-dGTP diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mutT</name>
        <name evidence="4" type="ORF">ERS852478_03787</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.55" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000049">
        <property type="protein sequence ID" value="CUO74838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380648.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000049.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74838">
        <property type="protein sequence ID" value="CUO74838"/>
        <property type="gene ID" value="ERS852478_03787"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO74838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="134" mass="15262" checksum="67CC438614F98A32" modified="2016-09-07" version="1">MKTIKVVAAVICDNMKEKNKIFATARGYGELKGGWEFPGGKIEAGETPQEALKREIMEELDTEIKVGDLIDTIEYDYPTFHLSMDCFWAEVTAGHLELKEAEAAKWLTKDQLDRVAWLPADVTLIEKIRRNMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HTN0</accession>
    <name>A0A174HTN0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacteriophage protein gp37</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Radical SAM mobile pair protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03828</name>
        <name evidence="2" type="ORF">GT712_15335</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000055">
        <property type="protein sequence ID" value="CUO76269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000037">
        <property type="protein sequence ID" value="MZS90404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704237.1">
        <property type="nucleotide sequence ID" value="NZ_WWVG01000062.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76269">
        <property type="protein sequence ID" value="CUO76269"/>
        <property type="gene ID" value="ERS852478_03828"/>
    </dbReference>
    <dbReference type="GeneID" id="66494472"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011101">
        <property type="entry name" value="DUF5131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031010">
        <property type="entry name" value="rSAM_mob_pairA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07505">
        <property type="entry name" value="DUF5131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04471">
        <property type="entry name" value="rSAM_mob_pairA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO76269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS90404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="229" mass="26864" checksum="DC8011C555C8D82E" modified="2016-09-07" version="1">MSICIKDQIQNMNIVIGCTVGCTYCYARNNVKRWHMIDDFADPEFFPGKLKMMEKKRPQNFLLTGMSDLSGWKPEWRDEVFAKIRENPQHQFLFLTKRPDLLDFDTDLENAWFGVTVTRKAERWRIDALRKNVRAKHYHVTFEPLFDDPGTVDLSGINWIVVGTMTGAQSRKIHTEPEWAWSLTDQAHKLGIPVFMKEDLVPIIGDENMIQEMPEEFNKVLEVQKSWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174J8H9</accession>
    <name>A0A174J8H9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">uppS</name>
        <name evidence="7" type="ORF">BWLFYP14_02380</name>
        <name evidence="3" type="ORF">ERS852478_02064</name>
        <name evidence="4" type="ORF">ERS852523_00024</name>
        <name evidence="6" type="ORF">GT712_14125</name>
        <name evidence="5" type="ORF">GT728_13825</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO94951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000035">
        <property type="protein sequence ID" value="MZL34252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000030">
        <property type="protein sequence ID" value="MZS90175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX66010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707655.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000073_gene2016"/>
    <dbReference type="EnsemblBacteria" id="CUO17782">
        <property type="protein sequence ID" value="CUO17782"/>
        <property type="gene ID" value="ERS852478_02064"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO94951">
        <property type="protein sequence ID" value="CUO94951"/>
        <property type="gene ID" value="ERS852523_00024"/>
    </dbReference>
    <dbReference type="GeneID" id="66493738"/>
    <dbReference type="eggNOG" id="COG0020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO17782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO94951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL34252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS90175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="235" mass="27297" checksum="C54A785223CF192F" modified="2016-09-07" version="1">MNVPNHIAIILDGNGRWAKAKGMPRSYGHVKGCANLETVCDYMKELGVKYVTVYAFSTENWKRSKDEVDGLMKLFRSYLKKCIKLADKNKMRVRVIGEVSAFDQDIQESIARLEQYSQKYDEIYFQIALNYGSRDEIIRGIRKLAQDAADGKVKPEEIDEHVFDNYLDTAGIPDPDLMIRTSGELRLSNFLLWQMAYTEFYFTDVAWPDFNKAELIKAIEKYNQRDRRYGGVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KX28</accession>
    <name>A0A174KX28_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rluC</name>
        <name evidence="8" type="ORF">BWLFYP14_02513</name>
        <name evidence="5" type="ORF">ERS852478_00012</name>
        <name evidence="6" type="ORF">ERS852523_00757</name>
        <name evidence="7" type="ORF">GT728_12690</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
            <strain evidence="6 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN40980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP16612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000031">
        <property type="protein sequence ID" value="MZL34034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055149671.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1376"/>
    <dbReference type="EnsemblBacteria" id="CUN40980">
        <property type="protein sequence ID" value="CUN40980"/>
        <property type="gene ID" value="ERS852478_00012"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16612">
        <property type="protein sequence ID" value="CUP16612"/>
        <property type="gene ID" value="ERS852523_00757"/>
    </dbReference>
    <dbReference type="GeneID" id="66492919"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="92"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN40980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP16612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL34034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="341" mass="39033" checksum="D74BD0AC5A2DF5B8" modified="2016-09-07" version="1">MKEFIIEENEAGQRFDKYLAKLLREAPKSFFYKMLRKKNITLNGKKATGNEKLLKGDTIKLFLSDETFDKFAGSSQAARAYCELDIVYEDPDIIIINKPAGMLSQPADDGEPSLVEYLTGYLLKKGDLTEEQLKTFRPSVCNRLDRNTSGMVCAGKSLAGLQFLSRIFHDRTLHKYYICLTKGKIEKPDHIRGYLHKDKKTNKVIVSRQEFKDSLPIETKYRPLGSNGKITLLEVELITGRTHQIRAHLAGTGHPLLGDTKYGDSEFNKQYIRHGVRHQLLHAYRLVIPETDQTFVAPAPELFCKIIKEENLEEAYHENLERNMGLRKNDHHSSSDRNACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L240</accession>
    <name>A0A174L240_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">purC</name>
        <name evidence="14" type="ORF">BWLFYP14_02555</name>
        <name evidence="10" type="ORF">ERS852478_00054</name>
        <name evidence="11" type="ORF">ERS852523_00713</name>
        <name evidence="13" type="ORF">GT712_07635</name>
        <name evidence="12" type="ORF">GT728_03170</name>
    </gene>
    <organism evidence="11 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">2789STDY5834863</strain>
            <strain evidence="11 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 19">BIOML-A1</strain>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP15470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000005">
        <property type="protein sequence ID" value="MZL32221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1418"/>
    <dbReference type="EnsemblBacteria" id="CUN42348">
        <property type="protein sequence ID" value="CUN42348"/>
        <property type="gene ID" value="ERS852478_00054"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15470">
        <property type="protein sequence ID" value="CUP15470"/>
        <property type="gene ID" value="ERS852523_00713"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="7"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN42348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP15470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL32221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS88942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX66183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="289" mass="32932" checksum="91AE4A5854B72A7B" modified="2016-09-07" version="1">MQEMKPIKEGKVREIYDNGDSLIMVATDRISCFDVILNNQVTKKGTVLTQMSKFWFDMTEDILPNHMISVDVKDMPEFFQQEKFDGNSMMCRKLEMLPIECIVRGYITGSGWESYKKTGKVCGIELPEGLKESDKLPEPIYTPSTKAEIGDHDENISYEQSIAHLEKYFPGRGEELAAKLRDNTIALYKKCAEYALSKGIIIADTKFEFGLDKDGNMVIGDEMLTPDSSRFWPAEGYEPGHGQPSFDKQFARDWLKANPDNDWTLPQDIVDKTIGKYLQGYEMLTGKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MG92</accession>
    <name>A0A174MG92_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">rpsM</name>
        <name evidence="15" type="ORF">BWLFYP14_00279</name>
        <name evidence="11" type="ORF">ERS852478_01681</name>
        <name evidence="12" type="ORF">ERS852523_01271</name>
        <name evidence="14" type="ORF">GT712_08865</name>
        <name evidence="13" type="ORF">GT728_04815</name>
    </gene>
    <organism evidence="12 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 16">2789STDY5834863</strain>
            <strain evidence="12 17">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="13 19 20" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 20">BIOML-A1</strain>
            <strain evidence="14 19">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="15 18" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP32945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707282.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2959"/>
    <dbReference type="EnsemblBacteria" id="CUO03457">
        <property type="protein sequence ID" value="CUO03457"/>
        <property type="gene ID" value="ERS852478_01681"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP32945">
        <property type="protein sequence ID" value="CUP32945"/>
        <property type="gene ID" value="ERS852523_01271"/>
    </dbReference>
    <dbReference type="GeneID" id="67479991"/>
    <dbReference type="eggNOG" id="COG0099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO03457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP32945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL32541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS89178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VUX67438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="122" mass="13834" checksum="C27E82B0F0220A54" modified="2016-09-07" version="1">MARIAGVDLPREKRIEIGLTYIYGIGRPSADKILAKAEVNPDTRVRDLTDDEVKRLSAVIDETMTVEGDLRREIALNIKRLQEIGCYRGIRHRKGLPVRGQKTKTNARTRKGPKRTVANKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MN57</accession>
    <name>A0A174MN57_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purine nucleoside phosphorylase DeoD-type</fullName>
            <shortName evidence="4">PNP</shortName>
            <ecNumber evidence="4">2.4.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">deoD</name>
        <name evidence="6" type="ORF">ERS852478_00536</name>
        <name evidence="7" type="ORF">ERS852523_01330</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
            <strain evidence="7 9">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase</text>
            <dbReference type="Rhea" id="RHEA:36431"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:142361"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexamer; trimer of homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000011">
        <property type="protein sequence ID" value="CUP35099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380050.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000146_gene775"/>
    <dbReference type="EnsemblBacteria" id="CUN58547">
        <property type="protein sequence ID" value="CUN58547"/>
        <property type="gene ID" value="ERS852478_00536"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP35099">
        <property type="protein sequence ID" value="CUP35099"/>
        <property type="gene ID" value="ERS852523_01330"/>
    </dbReference>
    <dbReference type="GeneID" id="66495175"/>
    <dbReference type="eggNOG" id="COG0813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042278">
        <property type="term" value="P:purine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09006">
        <property type="entry name" value="PNP_EcPNPI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01627">
        <property type="entry name" value="Pur_nucleosid_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004402">
        <property type="entry name" value="DeoD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF2">
        <property type="entry name" value="PTHR43691:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00107">
        <property type="entry name" value="deoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="5">
        <location>
            <begin position="19"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="90"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Purine nucleoside binding" evidence="4">
        <location>
            <begin position="182"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Purine nucleoside binding" evidence="4">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN58547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP35099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="234" mass="25416" checksum="5033356388836DF9" modified="2016-09-07" version="1">MSIPTPHNSAKKGDIAKKVLMPGDPLRAKYIAETYLENPVCFNTVRNMFGYTGTYKGEQISVMGSGMGMPSMGIYSYELYNFYDVEKIIRIGSAGALQDDVSVMDVVIAMSACTDSNYASQYQLPGTFAPTASYELVARAVEVAKEQGTPVRVGSVVSSDAFYGDNPESSKAWRKMGVLCVEMECAALFMNAARAGKEALGILTISDHVFRDEAISAEARQTSFNRMMEIALGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174N5S6</accession>
    <name>A0A174N5S6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Sucrose-6-phosphate hydrolase</fullName>
            <ecNumber evidence="3 8">3.2.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Invertase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">sacA</name>
        <name evidence="12" type="ORF">ERS852478_00381</name>
        <name evidence="13" type="ORF">ERS852523_01570</name>
        <name evidence="15" type="ORF">GT712_06075</name>
        <name evidence="14" type="ORF">GT728_06425</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">2789STDY5834863</strain>
            <strain evidence="13 17">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="14 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 19">BIOML-A1</strain>
            <strain evidence="15 18">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Enables the bacterium to metabolize sucrose as a sole carbon source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.</text>
            <dbReference type="EC" id="3.2.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Glycan biosynthesis; sucrose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="3 8"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000013">
        <property type="protein sequence ID" value="CUP42197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000011">
        <property type="protein sequence ID" value="MZL32846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000009">
        <property type="protein sequence ID" value="MZS88665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706700.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000060_gene469"/>
    <dbReference type="EnsemblBacteria" id="CUN52884">
        <property type="protein sequence ID" value="CUN52884"/>
        <property type="gene ID" value="ERS852478_00381"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP42197">
        <property type="protein sequence ID" value="CUP42197"/>
        <property type="gene ID" value="ERS852523_01570"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00238"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005985">
        <property type="term" value="P:sucrose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006232">
        <property type="entry name" value="Suc6P_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01322">
        <property type="entry name" value="scrB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="10">
        <location>
            <begin position="28"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="11">
        <location>
            <begin position="341"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN52884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUP42197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZL32846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZS88665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="494" mass="56871" checksum="560D2A4343788051" modified="2016-09-07" version="1">MSEMLEKARKYEFIQGQQIKEEERPAFHITPYVGWMNDPNGFSYYKGEYHLFYQYNPYSTHWDSMHWGHVVSKDLLHWNYVPTALAPDEDYDKFGCFSGSAIELEDGRQLLMYTSVNQEKLEDGTVRDIQTQAVAVGDGKDYEKYDKNPVLTAKDLPKGASKVDFRDPKIWKGNDGNFYCVIGSRPADGSGQILLYRSKNGFEWEFVSILAKNQNRYGKMWECPDFFELDGKYVLLTSPQDMLPEGLEFHNGNGTLCIIGELDPETHTLKEQFCQGVDYGIDYYAMQTLLAPDGRRIMIAWMQNWDTLAYRCNDSGWFAQMSLPRELSVKNGRLYQVPIRELNAMRANKVEYNNVVIKDTRLTLDQIEGRTVDLELVIRPADKDNLYKKFELCFAENEKYHSTLCFRPDESVLKIDRKFSGSERALVHQSSCLVNGDSNELKLRVILDKFSVEVFINDGEQVMSAVILTKQEAKGISFFADGAAKLDIVKYDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NQC0</accession>
    <name>A0A174NQC0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CdaR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Sugar diacid regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cdaR_2</name>
        <name evidence="4" type="synonym">cdaR_1</name>
        <name evidence="4" type="ORF">ERS852478_00649</name>
        <name evidence="5" type="ORF">ERS852523_01773</name>
        <name evidence="6" type="ORF">GT712_08685</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
            <strain evidence="5 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN62328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000016">
        <property type="protein sequence ID" value="CUP48868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000014">
        <property type="protein sequence ID" value="MZS89146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706081.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000063_gene712"/>
    <dbReference type="EnsemblBacteria" id="CUN62328">
        <property type="protein sequence ID" value="CUN62328"/>
        <property type="gene ID" value="ERS852478_00649"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP48868">
        <property type="protein sequence ID" value="CUP48868"/>
        <property type="gene ID" value="ERS852523_01773"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="123"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="294"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN62328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP48868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS89146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="362" mass="41426" checksum="BF37D2221F0A0C17" modified="2016-09-07" version="1">MKIQQILQKCLTDWKNISQIDFCLLDSDNHIFLSTCDKKLPAESKLEEFRQSSALCVSNTSCCLYKIMENHSISYILIVWGKAESTATIGELAVCQVQSLLAAYAEKSDKNTFMQNLLLGSYSDVDAFNCAKKLHIATSVQRAVFLVETKQTKDENALATIRNIFSARTRDFITAIDDTGIIIIRELQSTETYEDLESIAYMLVDMLNTEAMTSAWVAYSNLAEDISRLPDAYKEAHTALEVGKIFYADKNVFGYNQLGIGRLIYQLPVSICEMFIDEIFKEETLDSIDEETLITIRTFFENNLNLSETSRQLYVHRNTLVYRFEKLQRKFGLDIRAFEDALTFKLAMMVVDYIKYSKNHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174P702</accession>
    <name>A0A174P702_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="7">GSA</shortName>
            <ecNumber evidence="7">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="7">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">hemL</name>
        <name evidence="13" type="ORF">BWLFYP14_00131</name>
        <name evidence="9" type="ORF">ERS852478_02406</name>
        <name evidence="10" type="ORF">ERS852523_01993</name>
        <name evidence="12" type="ORF">GT712_04430</name>
        <name evidence="11" type="ORF">GT728_02015</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000019">
        <property type="protein sequence ID" value="CUP55301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL32010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381480.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1133"/>
    <dbReference type="EnsemblBacteria" id="CUO30144">
        <property type="protein sequence ID" value="CUO30144"/>
        <property type="gene ID" value="ERS852478_02406"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP55301">
        <property type="protein sequence ID" value="CUP55301"/>
        <property type="gene ID" value="ERS852523_01993"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO30144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP55301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL32010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS88358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX66578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="425" mass="45938" checksum="D3E96CC2452D8F33" modified="2016-09-07" version="1">MGLSEELFDRAVKVIPGGVNSPVRAYGAIGIAPRFIDRADGCHIYDVDGKEYVDYIDSWGPMILGHNFPEVKESVLKACEKGLSFGCATAIEVEMAEFICDHIPHVDMVRMVNSGTEAVMSAVRVARGFTGKNKIIKFAGCYHGHSDAMLVSAGSGVMTSGVPDSAGVPKGCTEDTMTAVYNDLDSVRALMEQADGQTAAVIVEAVGANMGVVPPKKGFLEGLRKLCDEYGALLIFDEVITGFRLAFGGAAEYFGVTPDLVTYGKIIGAGMPVGAYGGRREIMELVSPVGKVYQAGTLSGNPIAMAAGLTQLKYLYEHQEIYKDLEEKGKRLYGGMEKILAEKNLPYHINHVSSLGSLFFTEQEVVDYTSAKSSDTKAFSEYFKGMLAQGIHMAPSQFEAMFLSVAHTDEIIDQTLEAVRNYFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QF95</accession>
    <name>A0A174QF95_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="3">2.2.1.7</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Transketolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dxs_3</name>
        <name evidence="2" type="synonym">dxs_1</name>
        <name evidence="6" type="ORF">BWLFYP14_01231</name>
        <name evidence="2" type="ORF">ERS852478_00846</name>
        <name evidence="3" type="ORF">ERS852523_02499</name>
        <name evidence="5" type="ORF">GT712_07930</name>
        <name evidence="4" type="ORF">GT728_00975</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.2.1.7" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000026">
        <property type="protein sequence ID" value="CUP69628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS88999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706912.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000122_gene2855"/>
    <dbReference type="EnsemblBacteria" id="CUN71095">
        <property type="protein sequence ID" value="CUN71095"/>
        <property type="gene ID" value="ERS852478_00846"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP69628">
        <property type="protein sequence ID" value="CUP69628"/>
        <property type="gene ID" value="ERS852523_02499"/>
    </dbReference>
    <dbReference type="GeneID" id="66492974"/>
    <dbReference type="eggNOG" id="COG3958">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="7"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN71095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP69628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL31805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX64097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="312" mass="32971" checksum="D877168EADC418A7" modified="2016-09-07" version="1">MSEVKKIATRASYGAALVELGKKHENLVVLDADLAAATQTGVFKKEFPERHIDCGIAECNMMGIAAGLATTGKVPFASTFAMFAAGRAFEQVRNSIAYPKINVKIGATHGGISVGEDGATHQCCEDFALMRVIPGMVVACPSDDIEAKAMVEAAYEHVGPVYMRFGRLAVPVINDRPDYKFELGKGIVLREGKDLTIIANGLCVAPALEAAEKLAADGVDAKVINIHTIKPLDEELVVAAAKETGKVVTVEEHSVIGGLGGAVCECLSEKAPVPVKRIGVNDVFGESGPATALLEKYGLDAEGIYKQIKEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QK24</accession>
    <name>A0A174QK24_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">rpsR</name>
        <name evidence="11" type="ORF">BWLFYP14_00568</name>
        <name evidence="7" type="ORF">ERS852478_02734</name>
        <name evidence="8" type="ORF">ERS852523_02524</name>
        <name evidence="10" type="ORF">GT712_09845</name>
        <name evidence="9" type="ORF">GT728_09580</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000027">
        <property type="protein sequence ID" value="CUP70529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000019">
        <property type="protein sequence ID" value="MZL33442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000017">
        <property type="protein sequence ID" value="MZS89364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707906.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000058_gene2540"/>
    <dbReference type="EnsemblBacteria" id="CUO41135">
        <property type="protein sequence ID" value="CUO41135"/>
        <property type="gene ID" value="ERS852478_02734"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP70529">
        <property type="protein sequence ID" value="CUP70529"/>
        <property type="gene ID" value="ERS852523_02524"/>
    </dbReference>
    <dbReference type="GeneID" id="66493314"/>
    <dbReference type="eggNOG" id="COG0238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO41135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP70529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS89364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX62790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="87" mass="10237" checksum="9D49395227FE46C5" modified="2016-09-07" version="1">MAYNRGERPDSPMKRRGGRRRKKVCVFCGKENNEIDYKDVAKLRKYVSERGKILPRRITGNCAKHQRALTVAIKRARHMSMMPYIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SM23</accession>
    <name>A0A174SM23_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Predicted membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_00277</name>
        <name evidence="8" type="ORF">ERS852523_03473</name>
        <name evidence="9" type="ORF">GT728_11925</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
            <strain evidence="8 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000051">
        <property type="protein sequence ID" value="CUP97421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000028">
        <property type="protein sequence ID" value="MZL33887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380196.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000089_gene2818"/>
    <dbReference type="EnsemblBacteria" id="CUN49646">
        <property type="protein sequence ID" value="CUN49646"/>
        <property type="gene ID" value="ERS852478_00277"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP97421">
        <property type="protein sequence ID" value="CUP97421"/>
        <property type="gene ID" value="ERS852523_03473"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010540">
        <property type="entry name" value="CmpB_TMEM229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06541">
        <property type="entry name" value="ABC_trans_CmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN49646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP97421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="295" mass="33136" checksum="BBB40AF07B52D1B2" modified="2016-09-07" version="1">MICGMTYFQICLYFLIYSFGGWVVEVIFHAVALGKVINRGFLNGPVCPVYGFGVLSVFALLNTIQGSGRQMSDGMIFVFGIVLATAVELVAGWLLDVCFHARWWDYSDKPFNFHGYICLEFSLIWGLAIVMVVKVFQKYVEAHALHTPATWEWIVIAVLYAVYLTDFIVTVAVIQGLNKKLTRLDKVRSDLRIVSDKLSDTLATTTIGTAQKVGEGKVQATLAAAELRDATAAQREKSIEMLRIKRAELQAQFEELSSSITNHTVVGQGRIIKAFPKMQHRDYSELIQELKKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174TMK1</accession>
    <name>A0A174TMK1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein-tyrosine-phosphatase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Tyrosine-protein phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iphP</name>
        <name evidence="6" type="ORF">BWLFYP14_00083</name>
        <name evidence="2" type="ORF">ERS852478_03642</name>
        <name evidence="3" type="ORF">ERS852523_03933</name>
        <name evidence="5" type="ORF">GT712_04090</name>
        <name evidence="4" type="ORF">GT728_01740</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000071">
        <property type="protein sequence ID" value="CUQ09357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL31955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993720.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000170_gene504"/>
    <dbReference type="EnsemblBacteria" id="CUO70682">
        <property type="protein sequence ID" value="CUO70682"/>
        <property type="gene ID" value="ERS852478_03642"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ09357">
        <property type="protein sequence ID" value="CUQ09357"/>
        <property type="gene ID" value="ERS852523_03933"/>
    </dbReference>
    <dbReference type="GeneID" id="66494339"/>
    <dbReference type="eggNOG" id="COG2365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="1">
        <location>
            <begin position="219"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO70682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ09357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL31955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="350" mass="41449" checksum="3FBD138077B43E1C" modified="2016-09-07" version="1">MKYGKIRIEDGFLVFTRHMMINNLPCKDIVWAYMRKEGADEGDDRQLSVNYLVIVTRRKKRYKFDMTEKEIHECIRILKILNPDMATGFPKGGRISLHSLPNTRDLGAIVTADDRHILPRRLLRSGELYHISESDKNRLREEYNLKTVIDLRSAEERKCKPDTIIAEVEYYHVPVVDEDVQVISNREQFVKMLAGLPDDMEEYMIRQYRNLCMDQLVLKQYAKFIDILFRQEKGAVLWHCGTGKDRTGIGTAFLLSLLGVEEDVIYEDYLRTNRYMEPKLVYMQRLVQTWPEADEKMTEKLPIIYNVKEEYLAAVFETVKKTYGSMEKFFQTVFYLKPKMIEEFRNKYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174TNC0</accession>
    <name>A0A174TNC0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ilvH_3</name>
        <name evidence="14" type="synonym">ilvH_1</name>
        <name evidence="10" type="synonym">ilvH_2</name>
        <name evidence="12" type="synonym">ilvN</name>
        <name evidence="14" type="ORF">BWLFYP14_00084</name>
        <name evidence="10" type="ORF">ERS852478_03641</name>
        <name evidence="11" type="ORF">ERS852523_03934</name>
        <name evidence="13" type="ORF">GT712_04095</name>
        <name evidence="12" type="ORF">GT728_01745</name>
    </gene>
    <organism evidence="11 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">2789STDY5834863</strain>
            <strain evidence="11 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 19">BIOML-A1</strain>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000071">
        <property type="protein sequence ID" value="CUQ09378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL31956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704845.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000170_gene503"/>
    <dbReference type="EnsemblBacteria" id="CUO70660">
        <property type="protein sequence ID" value="CUO70660"/>
        <property type="gene ID" value="ERS852478_03641"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ09378">
        <property type="protein sequence ID" value="CUQ09378"/>
        <property type="gene ID" value="ERS852523_03934"/>
    </dbReference>
    <dbReference type="GeneID" id="66494338"/>
    <dbReference type="eggNOG" id="COG0440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO70660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUQ09378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL31956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS88292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX66531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="165" mass="18221" checksum="91F1F403984277FD" modified="2016-09-07" version="1">MQKRVLSLLVDNTAGVTTRVSGLFSRRGYNIDSITGGVTADERFSRITVVCSGDELILEQITNQLAKLVDVRDIKILEPDNSVCHELMMIKVAAKPEQRQGLISIADVFHAKVADVSVDSMILEMTGNHNKLEAFLELMGDYEILELARTGMTGLSRGSQDVTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WSJ7</accession>
    <name>A0A173WSJ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biotin synthase</fullName>
            <ecNumber evidence="8">2.8.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bioB_1</name>
        <name evidence="8" type="ORF">ERS852478_00057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199481.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN42453">
        <property type="protein sequence ID" value="CUN42453"/>
        <property type="gene ID" value="ERS852478_00057"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044271">
        <property type="term" value="P:cellular nitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018130">
        <property type="term" value="P:heterocycle biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901362">
        <property type="term" value="P:organic cyclic compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042364">
        <property type="term" value="P:water-soluble vitamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024021">
        <property type="entry name" value="FeFe-hyd_HydE_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034422">
        <property type="entry name" value="HydE/PylB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43726">
        <property type="entry name" value="PTHR43726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00348">
        <property type="entry name" value="FeFe_hydrogenase_maturase_(Hyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03956">
        <property type="entry name" value="rSAM_HydE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="52"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN42453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="349" mass="39447" checksum="4F5F0AD8F3CDCE7A" modified="2016-09-07" version="1">MASAELQIPEHIQETQNITREELEMILHTQNPLVTEELRRRAQQTAKAIYGNKIYVRGLIEFTNYCKNNCYYCGIRCSNTDADRYRLSLEQILSCCETGWNLGFRTFVLQGGEDPHFTDEHICQIVRTIKEIYPDCAVTLSIGEKSEESYQAYFDAGADRYLLRHETADEEHYRKLHPEQMSLVFRKNCLKTLKKIGYQTGCGFMVGSPGQTADTLYSDLLFIKELKPEMIGIGPFIPHKDTPFAKESPGTLEQTLRLLSIIRLIHPHALLPATTALGTIDPKGREKGILAGANVVMPNLSPVNVRDKYTLYDNKICTGDEAAECKACMAARMKSIGYEVVTDRGDYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WU07</accession>
    <name>A0A173WU07_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FAD-dependent oxidoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">NADH dehydrogenase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BWLFYP14_02539</name>
        <name evidence="9" type="ORF">ERS852478_00038</name>
        <name evidence="11" type="ORF">GT712_07715</name>
        <name evidence="10" type="ORF">GT728_12815</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 16">BIOML-A1</strain>
            <strain evidence="11 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HdrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000031">
        <property type="protein sequence ID" value="MZL34059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380681.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41805">
        <property type="protein sequence ID" value="CUN41805"/>
        <property type="gene ID" value="ERS852478_00038"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="578"/>
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            <end position="648"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN41805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL34059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS88958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX66167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="662" mass="71864" checksum="7010F5406B22A702" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WYI8</accession>
    <name>A0A173WYI8_9FIRM</name>
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        <recommendedName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Cell shape protein MreC</fullName>
        </alternativeName>
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    <gene>
        <name evidence="10" type="primary">mreC</name>
        <name evidence="12" type="ORF">BWLFYP14_02633</name>
        <name evidence="8" type="ORF">ERS852478_00135</name>
        <name evidence="9" type="ORF">ERS852523_01855</name>
        <name evidence="11" type="ORF">GT712_00785</name>
        <name evidence="10" type="ORF">GT728_15920</name>
    </gene>
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        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
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            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <text evidence="5">Involved in formation and maintenance of cell shape.</text>
    </comment>
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        <text evidence="1 5">Belongs to the MreC family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="ERS852478_00135"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUP51131"/>
        <property type="gene ID" value="ERS852523_01855"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    </dbReference>
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        </source>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="303" mass="33759" checksum="46F65AD90CB0FD04" modified="2016-09-07" version="1">MKNLKKKVHFRIKLKSKHLLVIMSIFCVSCIAATFSSGVTTAPLQDAAGILIVPFENSINRISSVLKGMQDRMRDKEEILSENENLKAQIDSLTEQNNKLIQDQTEYVRLQQMYNLDQQYTEYPKIAAEIISKDPGNWYDTFMINRGSADGIRVDNNVLADKGLVGIVTEVGTHWATVRSIIDDSSNVSAMTVSTQDNCVVEGDLELIDEGKLSFSQLYDQNNKVTVGERIVTSNISEKYVEGLFIGYVSEVEQNSNNLTKTGTIVTPVDFQHLKNVLVITVNKQDSVNDNAQAAQEATANEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WZR1</accession>
    <name>A0A173WZR1_9FIRM</name>
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        <submittedName>
            <fullName evidence="6">Bacterial Ig-like domain (Group 2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BWLFYP14_02646</name>
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            <taxon>Bacteria</taxon>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
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                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="entry name" value="Big_2"/>
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        <property type="entry name" value="FN3_sf"/>
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        </location>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN44963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS87648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="1140" mass="121970" checksum="D8B7F7BC9196A689" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X459</accession>
    <name>A0A173X459_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Copper-sensing transcriptional repressor CsoR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Copper-sensitive operon repressor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Metal-sensing transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">csoR_1</name>
        <name evidence="4" type="synonym">csoR_2</name>
        <name evidence="4" type="ORF">BWLFYP14_02654</name>
        <name evidence="1" type="ORF">ERS852478_00156</name>
        <name evidence="2" type="ORF">ERS852523_00313</name>
        <name evidence="3" type="ORF">GT712_00675</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
            <strain evidence="2 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000003">
        <property type="protein sequence ID" value="CUP03362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052769.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000112.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000032_gene401"/>
    <dbReference type="EnsemblBacteria" id="CUN45168">
        <property type="protein sequence ID" value="CUN45168"/>
        <property type="gene ID" value="ERS852478_00156"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03362">
        <property type="protein sequence ID" value="CUP03362"/>
        <property type="gene ID" value="ERS852523_00313"/>
    </dbReference>
    <dbReference type="GeneID" id="66495867"/>
    <dbReference type="eggNOG" id="COG1937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN45168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP03362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS87640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="105" mass="11902" checksum="C9A723B7E64E96EA" modified="2016-09-07" version="1">MADTQEKKVCPCCTKHTMRSEEERKKLINRLKRVEGQIRGIIGMLENDAYCNDILIQSAAVNAAVNAFNKELLASHIRNCVARDIREGKDETIDELVATLQKLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XDE4</accession>
    <name>A0A173XDE4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phage/plasmid primase, P4 family, C-terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_00252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN48907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199527.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN48907">
        <property type="protein sequence ID" value="CUN48907"/>
        <property type="gene ID" value="ERS852478_00252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004968">
        <property type="entry name" value="DNA_primase/NTPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006500">
        <property type="entry name" value="DNA_primase_phage/plasmid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045455">
        <property type="entry name" value="DUF5906"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19263">
        <property type="entry name" value="DUF5906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03288">
        <property type="entry name" value="Pox_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01613">
        <property type="entry name" value="primase_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="4">
        <location>
            <begin position="149"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN48907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="463" mass="52870" checksum="661421E4BF17D257" modified="2016-09-07" version="1">MAKNRKTPDMNLPVWFDGQNINEALFCEEFLHERRIIFANGAFFTPDGRVTDDLPLRGEIYDKLKFCAVNNIPRKITNILEVLKLEAQVPDFPPEQDRIHVFNGTLLLNGTFTEGRPAIVRSRLPVVYNPDAPAPVIWLNFLNGLLHAEDIPTLQEFIGYCLIPSNKGQRMMVIKGNGGEGKSQIGVVLSAIFGTNMKDGSIGKISENRFARADLEHILLCVDDDMRMEALRQTNYVKSIVTAQGKMDLERKGKQSYQGWMFARLLAFSNGDLQALYDRSDGFYRRQLVLTTKEKPVDRADDPDLAEKMKAESEGIFLWAFEGLQRLVANNFKFTESDRIRENREAVKRDNNNIFDFMDSEGYIQRKADASISSKDFYEIYRMWCEENSLAPLKARSFSDAMIANAKKFNLEHCNNITNSAGRRVWGFMGVEAIARPHINGFYGDSPCTYVPEDIPEEWRQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XFJ4</accession>
    <name>A0A173XFJ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase estB</fullName>
            <ecNumber evidence="2">3.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">estB</name>
        <name evidence="2" type="ORF">ERS852478_00309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50612">
        <property type="protein sequence ID" value="CUN50612"/>
        <property type="gene ID" value="ERS852478_00309"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN50612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="395" mass="44099" checksum="AB9B1515DE5DF778" modified="2016-09-07" version="1">MDIKEKISKVMKQAVDHCEVMGVNLLVEKGGEELLYCEEGMADRENRRLISRDTIFCLYSQTKPVTAACAMILMERGLLDPGEFVSEYLPSYSELKTADVHGTSPAKQPLRIIDLLNMTSGLVYPDDCTEPGKAADKVFAEACDRLDTDRPMTTRELADRLARCPLAFEPGTGWRYGTSADVLGAVIEVISGKKLSEFMQDELFAPLEMKDTAFWVPAEKQGRLAKAYETVTAEDGSKSMQLYTGNNLAVRNDMAKPPAYEAGGAGLASTLDDYMKFARMLRNGGRAGKREILKPETVRYMCSGQLLPVRQQDFDQWIGLDGFSYGNLMRVCKNPSQAVMFAREGEYGWDGWLGMYFANFPKEDMTILMGMQKKDAGTFPLTRKLRNVVISEYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XQZ2</accession>
    <name>A0A173XQZ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative multidrug export ATP-binding/permease protein SAV1866</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852478_00431</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199619.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54342">
        <property type="protein sequence ID" value="CUN54342"/>
        <property type="gene ID" value="ERS852478_00431"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="203"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="477"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="511"/>
            <end position="518"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN54342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="720" mass="79906" checksum="D4DE02C8A2A7BB01" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XRP3</accession>
    <name>A0A173XRP3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent helicase/nuclease subunit A</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase/nuclease AddA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">addA</name>
        <name evidence="12" type="ORF">ERS852478_00440</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -&gt; 5' nuclease activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of AddA and AddB/RexB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the helicase family. AddA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199624.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54602">
        <property type="protein sequence ID" value="CUN54602"/>
        <property type="gene ID" value="ERS852478_00440"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01451">
        <property type="entry name" value="AddA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014152">
        <property type="entry name" value="DNA_helicase_suAddA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF48">
        <property type="entry name" value="PTHR11070:SF48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02785">
        <property type="entry name" value="addA_Gpos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 9 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="10">
        <location>
            <begin position="3"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="11">
        <location>
            <begin position="518"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN54602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1269" mass="146648" checksum="410DEF0FD84D4375" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XTH8</accession>
    <name>A0A173XTH8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199616.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54227">
        <property type="protein sequence ID" value="CUN54227"/>
        <property type="gene ID" value="ERS852478_00427"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN54227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="333" mass="38951" checksum="4D4E486EBB6283FB" modified="2016-09-07" version="1">MQDNQEKCKELAIRIYNLDEEVYKCVGSSLGRTFTGQKETTLRHLAALMYTKPDGHLLRSELALISNMARTIRDKSERRRLMIEYDSILKEIESLPDTFGQTDIVDKERISLNNLIARRQNEISENDHLIICISRTQGSGGNDIGFELADQLQINYYDAEIFDQVMKRLQADKNAVGDAGSFERFDKYRKKKHTDLKTWFREFNRYHGLPKQDAVFFNMSDLICELAKSEDCVIMGRCADTILKNNHIPHISLFISAPFQVRVQHVMDIRNMNLKQAVRFLKQMDKQHKKYYEFYTGEKWGKPENYDLCINSANYGLKDTIELIQRMLDQKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XTM1</accession>
    <name>A0A173XTM1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199629.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54893">
        <property type="protein sequence ID" value="CUN54893"/>
        <property type="gene ID" value="ERS852478_00449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015686" evidence="2">
        <location>
            <begin position="25"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN54893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="252" mass="27198" checksum="6E818F421642EDB1" modified="2016-09-07" version="1">MKQKKIVIIMAGILAAAAAMTGCAEQNKTATQVDYTQNAQGKSEQAKQKTAEKSQPDKKQVNKSTSGGKENSNQTADKKTKVFASSNNAGDVQNSGNGTDGTEGTDTDDSQTTGVDTSASEDNGSTGNGGTQSDQRADQAMIYDSEGNGRLISEADDGNWYDSDGNYYGSWEDIEDAMVNENGVTDQDGNKYYWTAPHDASEEVTDPYDLYSWDPGTNSYIPFQAAESDCSPIGRGNGWYYYDEDSGEYVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XYL5</accession>
    <name>A0A173XYL5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mg-protoporphyrin IX methyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199662.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56749">
        <property type="protein sequence ID" value="CUN56749"/>
        <property type="gene ID" value="ERS852478_00479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="67"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN56749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="294" mass="34522" checksum="D5C429519EF3A305" modified="2016-09-07" version="1">MDSILDYFISLQESEPAELPERAIERWNKRADFWEDARKKKEKGDERVISAINYLDSKGLLEKNYDVADIGCGPGRFAAAFAKYVHKVVGLDISDKMVKHGMEHIQNEGLNNAILYTCNFQTLDIDKSGYKHAFDLVFSSMTPAIHNMDELIKSMEMSRAWCCNITHLDRRNSLRKQILQEVFGKQTAPQWNGRWFFSLFNILFLLGYNPETSYEKLHRETWVTPDEQYIDFLMEHMLPSEEHTQENANKIMQWIQSHLNKDGQIKEITDSTYGRILWDVRNKTIRPDYRTIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y400</accession>
    <name>A0A173Y400_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Manganese transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mntR_2</name>
        <name evidence="7" type="ORF">ERS852478_00539</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706218.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000046.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58629">
        <property type="protein sequence ID" value="CUN58629"/>
        <property type="gene ID" value="ERS852478_00539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN58629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="126" mass="14105" checksum="FF7F5B8F3712AB53" modified="2016-09-07" version="1">MQIRKSAEDYLEAILVLSKQGGGVRSIDIATMLGVSKPSVSHAMKLLREDGYIAMDRYGTVTLLEKGNDIAVHIYERHTVLSKMLEHLGVSPEVAKEDACKLEHDLSDESFTRIKEHFHKVIGEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y6T8</accession>
    <name>A0A173Y6T8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ComE operon protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">comEA</name>
        <name evidence="3" type="ORF">ERS852478_00570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59589">
        <property type="protein sequence ID" value="CUN59589"/>
        <property type="gene ID" value="ERS852478_00570"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00426">
        <property type="entry name" value="TIGR00426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="2">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN59589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="293" mass="30970" checksum="9DF4C734142EF441" modified="2016-09-07" version="1">MIKIKNRCCYTVTLILCGTLFLTGLTGCKSREAQFLIDGLQEAKAEVDAESSEEKTSGQKSKKDTDEKKADTEDRQNDDGSSAESWKKQAESDGSDAGNGTGSDSGKHISDADIDNGSEAVSDKEMQQAMIYVDVCGAVANPGVFQLAAGSRVFQAIEAAGGYLPEAALTCVNRAGVLTDGQQLYILTQEEMERQGLDPAEMSGASDGQMNGSAGTGQNTGMTAQVQQDNRININTADEAQLTTLTGIGATRAQAIIAYREENGPFAAIEDIMNVQGIKEGTFAKIKDEIVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y7V5</accession>
    <name>A0A173Y7V5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formate dehydrogenase accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59949">
        <property type="protein sequence ID" value="CUN59949"/>
        <property type="gene ID" value="ERS852478_00580"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN59949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="272" mass="30680" checksum="39C3D00C7857DF00" modified="2016-09-07" version="1">MKINEQYHDLNLLENVTYEFLGRDGETHEETEPILVEHMMDVYVNERLTMKLVCIPQHLTELVLGRLFTEGIISSAEDVEQIYICEFGKRARVILSKNKSGQSHEENEDYVAPTPTCCTGNRVLNDYFITDQPMTPVTPVPWKKQWIFDLADCFANGTPLHSQTWATHSCFLACDGELLFQCEDIGRHNALDKAIGYALRHNIDLKKCVVYSSGRIPTDMAVKAIRAGIPVLASKASPSAEAVAMAKEYHLTLICAARRDRMKLFTGNNPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YB04</accession>
    <name>A0A173YB04_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rmlC</name>
        <name evidence="6" type="synonym">rfbC</name>
        <name evidence="8" type="ORF">BWLFYP14_03234</name>
        <name evidence="4" type="ORF">ERS852478_00622</name>
        <name evidence="5" type="ORF">ERS852523_01801</name>
        <name evidence="7" type="ORF">GT712_08550</name>
        <name evidence="6" type="ORF">GT728_05435</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">2789STDY5834863</strain>
            <strain evidence="5 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 13">BIOML-A1</strain>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000016">
        <property type="protein sequence ID" value="CUP49589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000009">
        <property type="protein sequence ID" value="MZL32662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000014">
        <property type="protein sequence ID" value="MZS89120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX66957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706119.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000022_gene1724"/>
    <dbReference type="EnsemblBacteria" id="CUN61391">
        <property type="protein sequence ID" value="CUN61391"/>
        <property type="gene ID" value="ERS852478_00622"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP49589">
        <property type="protein sequence ID" value="CUP49589"/>
        <property type="gene ID" value="ERS852523_01801"/>
    </dbReference>
    <dbReference type="GeneID" id="66492519"/>
    <dbReference type="eggNOG" id="COG1898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN61391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP49589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL32662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS89120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="184" mass="20954" checksum="6FC4D9A2AD1F5E3A" modified="2016-09-07" version="1">MGKIKVTECGGIKGLKVVEPTVFGDARGYFMETYNYNDFKEAGIDVEFVQDNQSSSHKGVLRGLHFQINYPQDKLVRVVNGEVFDVAVDLREGSETYGKWFGVVLSAENKKQFFIPKGFAHGFLVLSEHAEFVYKCSDFYHPNDEGGLIWNDPDIGVEWPIPEGMELSFSDKDTKWGSFKEYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YD88</accession>
    <name>A0A173YD88_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">clpX_1</name>
        <name evidence="9" type="synonym">clpX</name>
        <name evidence="11" type="synonym">clpX_3</name>
        <name evidence="11" type="ORF">BWLFYP14_03220</name>
        <name evidence="7" type="ORF">ERS852478_00636</name>
        <name evidence="8" type="ORF">ERS852523_01786</name>
        <name evidence="10" type="ORF">GT712_08620</name>
        <name evidence="9" type="ORF">GT728_16860</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000016">
        <property type="protein sequence ID" value="CUP49197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000054">
        <property type="protein sequence ID" value="MZL34815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000014">
        <property type="protein sequence ID" value="MZS89134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX66943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706095.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000063_gene700"/>
    <dbReference type="EnsemblBacteria" id="CUN61904">
        <property type="protein sequence ID" value="CUN61904"/>
        <property type="gene ID" value="ERS852478_00636"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP49197">
        <property type="protein sequence ID" value="CUP49197"/>
        <property type="gene ID" value="ERS852523_01786"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="162"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="6">
        <location>
            <begin position="364"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN61904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP49197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL34815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS89134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX66943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="472" mass="52936" checksum="BA0B9D6A011B77F9" modified="2016-09-07" version="1">MSENYNDDEIIDSSEDTEKKRNKSEKFCFLCRRPESKAGPMIELPNNIHVCTDCMQKSFNSMNQQFNEGKFNYSDLLNMPNVSMIDLGSFQNPVQQPKKEKKKKKQEKPVLDLKNIPAPHKIKETLDQYVIGQEKAKKVMSVAVYNHYKRVATDTMDEIEIEKSNMLMIGPTGCGKTYLVKTLAKLLDVPLAIADATSLTEAGYIGDDIESVVSKLLAAADNDVERAEHGIIFIDEIDKIAKKKNTNQRDVSGEAVQQGMLKLLEGSEVEVPVGANSKNAMVPLVTVNTRNILFICGGAFPDLENIIKERLNKQASIGFYADLKDKYDNDPHLLQKVTVEDIRSFGMIPEFIGRLPIIFTLDGLNEDMLVKILQEPKNAILKQYQKLLALDEVKLEFEDGALHAIAAKALERDTGARALRAILEEYMLDIMYEIPKDDSIGEVVITREYIEGNGGPKILLRGQEPILLEGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YFD9</accession>
    <name>A0A173YFD9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">16S ribosomal RNA methyltransferase KsgA/Dim1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_03231</name>
        <name evidence="3" type="ORF">ERS852478_00625</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX66954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706113.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61498">
        <property type="protein sequence ID" value="CUN61498"/>
        <property type="gene ID" value="ERS852478_00625"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_12" evidence="2">
        <location>
            <begin position="78"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="691"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN61498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="730" mass="85089" checksum="5BA2D3F16B9670E6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YHQ2</accession>
    <name>A0A173YHQ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC exporter transmembrane subunit, DevC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_00654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN63474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63474">
        <property type="protein sequence ID" value="CUN63474"/>
        <property type="gene ID" value="ERS852478_00654"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="85"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="559"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN63474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="644" mass="71053" checksum="6F45F86E4292D64A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YM71</accession>
    <name>A0A173YM71_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_00666</name>
        <name evidence="7" type="ORF">ERS852523_00680</name>
        <name evidence="9" type="ORF">GT712_03360</name>
        <name evidence="8" type="ORF">GT728_03610</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">2789STDY5834863</strain>
            <strain evidence="7 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">BIOML-A1</strain>
            <strain evidence="9 12">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN63878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP13965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055149581.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000015_gene3740"/>
    <dbReference type="EnsemblBacteria" id="CUN63878">
        <property type="protein sequence ID" value="CUN63878"/>
        <property type="gene ID" value="ERS852478_00666"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13965">
        <property type="protein sequence ID" value="CUP13965"/>
        <property type="gene ID" value="ERS852523_00680"/>
    </dbReference>
    <dbReference type="GeneID" id="66493438"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="148"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN63878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP13965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL32303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS88151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="249" mass="28598" checksum="C8601EB83D79D3F0" modified="2016-09-07" version="1">MRILIAEDEQRTRQGLVRVLQSLRDEYEIVAQASNGKAALEMILEQKPDVVFIDIKMPFMDGLSVIEAARAQGIKAEFVIVSAYADFDFAKQSISLGVIEYLLKPLTRDEAEAVLKKIENKISGKNSYSRRKSRNLRDKYPDAHPMILQALDIIQSGYAGKISQKKLAEDLGLSQEYFSYLFGKNIGENFSTFLREYRIEQAQYMLREEICDQRDVPYQVGFSDSKYFKKVFREVTGKSPSEYLSEIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YM98</accession>
    <name>A0A173YM98_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Penicillin-binding protein 2x</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pbpX</name>
        <name evidence="6" type="ORF">ERS852478_00708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transpeptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65281">
        <property type="protein sequence ID" value="CUN65281"/>
        <property type="gene ID" value="ERS852478_00708"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_dimer" evidence="5">
        <location>
            <begin position="71"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="4">
        <location>
            <begin position="281"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="697"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="719"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN65281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="746" mass="81367" checksum="36B8E52D28D88FF4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YQ66</accession>
    <name>A0A173YQ66_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA ATPase containing von Willebrand factor type A (VWA) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199775.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65683">
        <property type="protein sequence ID" value="CUN65683"/>
        <property type="gene ID" value="ERS852478_00722"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_5" evidence="1">
        <location>
            <begin position="67"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN65683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="310" mass="35145" checksum="0B6E8DE44891DBDE" modified="2016-09-07" version="1">MRNHWTEIEKYLEDQKIAQELIGELRDFHMRYEVEDQVKERIEKPDILFYGKKILEMSIAALLQGDNLLLSGAKATGKNVLCETLAWIFGRPEYDISFHVNTDSADLIGTDTFINNEVRLRKGPIYQCAEFGGFGILDEINMAKNDAVSVLHATLDHRRRIDIPGYNRILLHPATRFIGTMNYGYAGTRELNEALVSRFMVIDMPEMDEDSVLFVLRQHFPEGKKSALKAFAGLFLDLQIKAYHGEISTKSLDLRGLVSAVKATRSGLSPIEAIQMGIINKSFDVFEKEIVEDVVSTRIPSSWTGKDIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YXL8</accession>
    <name>A0A173YXL8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_01738</name>
        <name evidence="1" type="ORF">ERS852478_00783</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199794.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67986">
        <property type="protein sequence ID" value="CUN67986"/>
        <property type="gene ID" value="ERS852478_00783"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN67986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX64901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="299" mass="33549" checksum="B97F2ADE6C38F4A8" modified="2016-09-07" version="1">MKKYSVAVCVCAVLFSVGIHGGGMREVSARAPGADENLAILQDIIRENECQAGMAFLGYTYEGAEAAEILEYTRQGEVAAAYPFLQDGTVVDAGGYEIYAIVPGDDCRVSVYPAQPTEEGEYLDDLNAPYYTGKENEIIILRCNVSEIHSNVMVSVQKQNMSIQYHPMVSLKDGHLAAETHCYDFSIYYNWDEYDPEYNPVYESEYDQECNPEHDSALNIKIAREQLSETDEVSYYLGLGMSLWYTGTEEYIEGRNCPVFVLGTDHEDHFTKEHYYAVGDNVVYYYDPSGDAWLLLGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YZE9</accession>
    <name>A0A173YZE9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Making large colonies protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mlc_1</name>
        <name evidence="4" type="ORF">ERS852478_00822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional repressor of xylose-utilizing enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379994.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69354">
        <property type="protein sequence ID" value="CUN69354"/>
        <property type="gene ID" value="ERS852478_00822"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN69354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="370" mass="41313" checksum="182672187BE14941" modified="2016-09-07" version="1">MSGLEKKFATKSKIVNYIINRESTSKVEISKELNLSMPTVLSNVKDLLEKGIIIETGEYESTGGRKAKSIGINPSYRYAMGIVITANHLGMVLVNLKYEIVKSERIRLKFVSDMSYCSQVADFATKFLNHMNDAEQKEKLLGVGISIPGIINQEQKLVIKSHALKLENYSLSFLEQAFSVPVYFSNDANAAMMAEDMNTYQNAIYLSLNQTLGGAFCIRGNLFSGENQKAGEFGHMILVPQGRKCYCGKSGCADAYCAAGALVVESKDSVEQFMQLLQNNDEKAEKKWEEYLDYLAILISNLRMAYDMDIILGGEMGGYLSDYMIPLGEKVMKYNGFDHDLRYLKNCSYKKEASAVGAAKHFLQDFIGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZCR5</accession>
    <name>A0A173ZCR5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380928.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73450">
        <property type="protein sequence ID" value="CUN73450"/>
        <property type="gene ID" value="ERS852478_00930"/>
    </dbReference>
    <dbReference type="GeneID" id="66493045"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN73450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="73" mass="8149" checksum="5FD9831BB203776E" modified="2016-09-07" version="1">MMNAVNTTQRMRRKERHKFSRTMAVILGLIVTLEVMVAGGMIFNIDFHSADMVAVVMGFMVLYAGIVAILTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZH34</accession>
    <name>A0A173ZH34_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-N-arabinofuranosidase 2</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577880.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75437">
        <property type="protein sequence ID" value="CUN75437"/>
        <property type="gene ID" value="ERS852478_00991"/>
    </dbReference>
    <dbReference type="GeneID" id="66493236"/>
    <dbReference type="eggNOG" id="COG3940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016828">
        <property type="entry name" value="Alpha-L-arabinofuranosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025414">
        <property type="entry name" value="Alpha-L-arabinofuranosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN75437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="318" mass="36700" checksum="4D31E0A4997CB39E" modified="2016-09-07" version="1">MSEELKYNEPWILQRADPYVYRHTDGNYYFTASIPAYDRIVLRRSETLAGLKDAEEVTVWEKHKEGIMSEHIWAPELHYLDGKWYIYFAGGDKDDIWAIRPYVLECADTDPLTGAWTEKGKMGRADADEFSFEAFSLDATVFENKGKHYYVWAEKVGVGKQISNLYIGEMETPYKLKTVQVLLTSPDYDWERVGFWVNEGPAVIHHDGRIYLTYSASETGAAYCMGMLTADEDSDLLDPKSWTKERYPVLRTDESRGIYGPGHNSFTEDEEGNPVMVYHARTEAEIEGNPLYNPNRHAMLMKIRWDEKTGAPIFSYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZHB0</accession>
    <name>A0A173ZHB0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione import ATP-binding protein GsiA</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_5</name>
        <name evidence="6" type="ORF">ERS852478_00976</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199864.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74876">
        <property type="protein sequence ID" value="CUN74876"/>
        <property type="gene ID" value="ERS852478_00976"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN74876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="342" mass="38004" checksum="AF1C124B52D4CCAB" modified="2016-09-07" version="1">MDNQKIILNVENLNTTFVSDKKEIKIVKNVSFQVKRGKTLAVVGESGCGKSVTMNSIMRFTGKNAIVKADSIQYNALHDGKVTEYHLESITKPNGPEMRALRGPDLSMVFQDPMSSLNPVYKVGDQVAEGLLQHNKGMKKAEAREKVLEMFRKLGIPDPEERIDCYPHQFSGGMKQRVVIAIAMICNPELIICDEPTTALDVTIQAQIMELLKSLQVNEGKSIILITHNMGLVAEMADEVCVMYMGRVVEFGSLEDIFDHTSHPYTKALLRSVPVLGLGDDQKLETIPGVTPNPADLKEGCEFADRCSECMEKCRKGKIPAFEVSPGHKVRCLKFDSYPEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZVQ2</accession>
    <name>A0A173ZVQ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphorylated carbohydrates phosphatase TM_1254</fullName>
            <ecNumber evidence="2">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80522">
        <property type="protein sequence ID" value="CUN80522"/>
        <property type="gene ID" value="ERS852478_01110"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN80522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="275" mass="32053" checksum="CE0151531EE09D95" modified="2016-09-07" version="1">MKKDNNKIKKIGAWIAIIILLLACCMPMIFAFGNGEDSQVYFKASLAVAIMVPIMAYAIWMVYKLLNRNKKVVDSDMENIIFDVGQVLVKYDWETYLDSFGFPKEERDKIAEVVFQSNTWNERDRSSETEQYYVDQMVKAAPEYEKDIREVMRRSDETIEKTDYAETWVRYLKDKGYHVYILSNYAADTLERTEDKLTFLKYVDGAVFSCQVKQIKPEPEIYKTLLGRYHLDPEKSVFLDDRAENCEAARKQGIHAIQFKTFKQAAAELEKLGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A6V8</accession>
    <name>A0A174A6V8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">ribD</name>
        <name evidence="16" type="ORF">BWLFYP14_03014</name>
        <name evidence="15" type="ORF">ERS852478_01221</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN84442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84442">
        <property type="protein sequence ID" value="CUN84442"/>
        <property type="gene ID" value="ERS852478_01221"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="301"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUN84442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VUX66738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="375" mass="41238" checksum="2C144996A871C881" modified="2016-09-07" version="1">MKDITDMEKDRQYMKMALELAQKGMGFTAPNPMVGAVIVKSGKVIGQGYHRKYGELHAEREALASCTEQPEGASIYVTLEPCCHYGKQPPCVNAILESGIRRVIIGSSDPNPLVSGKGIRILKEHGIEVTENVLKEECDKLNEAFFYYIQNQKPYVVMKYAMTMDGKIATYTGASRWVTGEAARMHVQKQRLKYTGIMAGVGTVLADDPMLTCRLENGRNPVRIICDSHLRTPLNSRIVKTASTIPTIFATSSKDQQKIKNYEDMGCKVLDVPEKNGHIDLNRLMELLGAAKIDSILLEGGGTLNWSALESGIVQKVQTYIAPKLFGGESAKTPIEGKGFPDPASAILLKNSEIIRIGDDFLIESEVKSNVHGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AD32</accession>
    <name>A0A174AD32_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199987.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86532">
        <property type="protein sequence ID" value="CUN86532"/>
        <property type="gene ID" value="ERS852478_01248"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033X21">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN86532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="97" mass="11049" checksum="CD1223941C78ABB9" modified="2016-09-07" version="1">MKKYDVTLTAHYQKTVSVYAESPEQAKEKTKIILFDTDLIDFTDDDFVCGEADITEQSEDGLDVAGENTLQENEDCSDCPYFCPVCGECMYEDDYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AN36</accession>
    <name>A0A174AN36_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">ispG</name>
        <name evidence="6" type="synonym">gcpE</name>
        <name evidence="7" type="ORF">BWLFYP14_01660</name>
        <name evidence="5" type="ORF">ERS852478_01320</name>
        <name evidence="6" type="ORF">GT712_09505</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705719.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000087.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89020">
        <property type="protein sequence ID" value="CUN89020"/>
        <property type="gene ID" value="ERS852478_01320"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0821">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN89020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS89299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX64804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="350" mass="37561" checksum="76F74330C8CD1E09" modified="2016-09-07" version="1">MYRDHTKVIQIGDRKIGGGNPILIQSMTNTKTEDVEQTVAQILALEQAGCDIIRCAVPTMEAAKALKEIKKQIHIPLVADIHFDYRLAIAAMENGADKIRINPGNIGSTERIKAVVDVAKERGIPIRVGVNSGSLEKELVEKYHGVTAEGLVESALDKVHIIEDLGYDNLVISIKSSDVLMCAKAHELIAEKTNYPLHVGITEAGTLYSGNIKSAIGLGIILNQGIGDTIRVSLTGAPLEEIKSAKRILKTLGLRKGGIEVVSCPTCGRTQIDLIGLANKVETMVQDIPLDIKVAVMGCVVNGPGEAKEADIGIAGGVGVGLLIKHGEIIKKVPEDQLLDTLREELLNWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AZP3</accession>
    <name>A0A174AZP3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage head morphogenesis protein, SPP1 gp7 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93924">
        <property type="protein sequence ID" value="CUN93924"/>
        <property type="gene ID" value="ERS852478_01434"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006528">
        <property type="entry name" value="Phage_head_morphogenesis_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04233">
        <property type="entry name" value="Phage_Mu_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_Mu_F" evidence="1">
        <location>
            <begin position="200"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN93924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="312" mass="35927" checksum="C0A0C6C9757808D0" modified="2016-09-07" version="1">MLKMRARSRMIKKSVESQKVLEALDNYLESNLEEPMKWLVRFWKDQAAVMLYKDLREIVIGEADPQSLFDQWFSDYSVFLSSKMTASWESAYFAAWNSTAEFVALEEKVSSEIYVRDWIINRTGNLITNVCSDQVNAVRYLIAEAQSLGMSSDETARYIRPTVGLTERQAAANLRHYNSVKTQLRADHPRMKEESIERKARTAAAKYAERQQRYRAETIARTEIAQAYNAGADAFIREAMRHDLMPEMKKEWSTALDGRVCKECQALEGVQISMDDSFETQSGRRNVTVLLPPLHPRCKCAVKYVEATYEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AZT9</accession>
    <name>A0A174AZT9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200073.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93479">
        <property type="protein sequence ID" value="CUN93479"/>
        <property type="gene ID" value="ERS852478_01418"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN93479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="111" mass="12838" checksum="BE49BFF5E4CDA0DB" modified="2016-09-07" version="1">MKKQWNYVEKDGNPKKAGLYWVTLIYPERKDGKKTGKFMAEVDTRYFADLDKEPDLRGLTMDGEPDSGFAWTEECGSISGERVHAWMPMEDIRIAELPEGVENRNFESMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B1J4</accession>
    <name>A0A174B1J4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200077.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93640">
        <property type="protein sequence ID" value="CUN93640"/>
        <property type="gene ID" value="ERS852478_01424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN93640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="76" mass="8723" checksum="97AFC32D7CFFFC2D" modified="2016-09-07" version="1">MDKSLYNASGCKDRTAHDAICAADRTRTLVYRASRTKKDEEAELFVKMVKRLAKGFGFKLCDRIKFEDPETGKKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B2U6</accession>
    <name>A0A174B2U6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200101.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94713">
        <property type="protein sequence ID" value="CUN94713"/>
        <property type="gene ID" value="ERS852478_01458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN94713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="200" mass="21906" checksum="1CA26455FDEC23FA" modified="2016-09-07" version="1">MANVVIPENPEFNEALRIIETEDLVHANVVNPMFRTLLLNTIYLERRVAKMIERIDTLAIDNTYGGPELSADANIVDASAQFSVIRKTSSTASVQTLFQKAIDSLRKGLYSLLIRVKVNSNSNNGGLIELNVTSGGAILETRTITANMFERAGVYQTFGLNVELNDTVTITARLLKNSANITVSVDYVMLQPAQTAITSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B4R6</accession>
    <name>A0A174B4R6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rsbV</name>
        <name evidence="8" type="ORF">BWLFYP14_00991</name>
        <name evidence="4" type="ORF">ERS852478_01487</name>
        <name evidence="5" type="ORF">ERS852523_00792</name>
        <name evidence="7" type="ORF">GT712_13115</name>
        <name evidence="6" type="ORF">GT728_10940</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">2789STDY5834863</strain>
            <strain evidence="5 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 13">BIOML-A1</strain>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP17550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000024">
        <property type="protein sequence ID" value="MZL33699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000026">
        <property type="protein sequence ID" value="MZS89986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704342.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1342"/>
    <dbReference type="EnsemblBacteria" id="CUN95704">
        <property type="protein sequence ID" value="CUN95704"/>
        <property type="gene ID" value="ERS852478_01487"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17550">
        <property type="protein sequence ID" value="CUP17550"/>
        <property type="gene ID" value="ERS852523_00792"/>
    </dbReference>
    <dbReference type="GeneID" id="66492615"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN95704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP17550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL33699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS89986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX63505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="100" mass="11088" checksum="9C015827F6083FEF" modified="2016-09-07" version="1">MEIITKTEGNKATMEISGWLDTQTAPQLGEALSGLEDSITSLVFDFTNLEYISSAGLRQVIVAYKKMAQKDGFKIINVSDEVYDVFSLTGFDSKIDIQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B798</accession>
    <name>A0A174B798_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug export protein mepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_7</name>
        <name evidence="2" type="ORF">ERS852478_01485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380987.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95636">
        <property type="protein sequence ID" value="CUN95636"/>
        <property type="gene ID" value="ERS852478_01485"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN95636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="581" mass="63418" checksum="EBB0A70FAE7B5118" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B9N8</accession>
    <name>A0A174B9N8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200134.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97731">
        <property type="protein sequence ID" value="CUN97731"/>
        <property type="gene ID" value="ERS852478_01541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN97731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="238" mass="25547" checksum="287EB9CD4425FD6B" modified="2016-09-07" version="1">MNAKKFSDAMSELDTKYVDEALNYKKKAKKPIWVKWGAIVACFAVIAVLGVGVFQNGLFGNKTDIATLDNGNEIIFVKSETAGSSIDIDGTITTRQLTETEAASLFPNLTVTAHAVFRVDDTVSDSNKELIGFEGKIENAKVVISTTDIALLDTKIVGSEESSEVNGTSVTAGYFVTDRNSVGEQNVIYYATFKLGDSTVYVENAGAKTESESVKNDLATIIQELINNGALDLSSFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BIN1</accession>
    <name>A0A174BIN1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057313.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00574">
        <property type="protein sequence ID" value="CUO00574"/>
        <property type="gene ID" value="ERS852478_01600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040568">
        <property type="entry name" value="LPD16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041045">
        <property type="entry name" value="LPD25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025923">
        <property type="entry name" value="YodL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18830">
        <property type="entry name" value="LPD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18840">
        <property type="entry name" value="LPD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14191">
        <property type="entry name" value="YodL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LPD16" evidence="2">
        <location>
            <begin position="368"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="LPD25" evidence="3">
        <location>
            <begin position="689"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO00574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="919" mass="106606" checksum="98B59F64A1B3E670" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BJ69</accession>
    <name>A0A174BJ69_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plipastatin synthase subunit D</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ppsD</name>
        <name evidence="3" type="ORF">ERS852478_01611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01052">
        <property type="protein sequence ID" value="CUO01052"/>
        <property type="gene ID" value="ERS852478_01611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO01052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="75" mass="8656" checksum="EF4225ACE5E87D7D" modified="2016-09-07" version="1">MERIMQEIWKEVLKLQKMPSIGDSFFDLGGNSFLAVQVIAILEEKYGKTIDIIAFYECETIENLVARIENKESLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BZN2</accession>
    <name>A0A174BZN2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Anaerobic sulfatase-maturating enzyme</fullName>
            <ecNumber evidence="9">1.8.98.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852478_01741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.8.98.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200212.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06087">
        <property type="protein sequence ID" value="CUO06087"/>
        <property type="gene ID" value="ERS852478_01741"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034485">
        <property type="entry name" value="Anaerobic_Cys-type_sulfatase-m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00289">
        <property type="entry name" value="anaerobic_Cys-type_sulfatase-m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01384">
        <property type="entry name" value="thioether_bond_formation_requi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="12"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="SPASM" evidence="8">
        <location>
            <begin position="263"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO06087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="372" mass="43727" checksum="83A483B2EBD71186" modified="2016-09-07" version="1">MPAISVLMKPSSSMCNMSCDYCFYCDEAQKRTQESFGYMSEQTLKNIIRKTMLRAEGMISYTYQGGEPTLRGVGFFKKAIEFQNQYNRNHVQVQNALQTNGYAITEEWCQFFKDNHFLIGLSVDGTEEIHNSMRHTHSGSGTFARVNQTAMLMDEYGVDYNILTVVTPKIAENIREIYGTYQRRGWYYQQYIACLDPFGEEHGKTPYSLSPEVYGQFLTDLFWLWYKDLRRGKQPFIRQFENYVGLAAGYMAESCEQRGVCGIQNVVEADGSVYPCDFYMMDKYRLGNFNTDRLDDINQRRSEIQFIEQSWKLDEECRFCKYFRLCRGGCQRNRDFQPDTGLYKNYFCEGYRMFFRQCYEQIMEIGKSLSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C5T9</accession>
    <name>A0A174C5T9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fucose 4-O-acetylase and related acetyltransferases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060165.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07260">
        <property type="protein sequence ID" value="CUO07260"/>
        <property type="gene ID" value="ERS852478_01778"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="3">
        <location>
            <begin position="16"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO07260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="452" mass="51946" checksum="CBE01F3DD47462C5" modified="2016-09-07" version="1">MKIKKERAAVPYSCLIDNIKVLLIFLVVFNHIIAFNLVKVDTVVRYVWYAITIFHMPAFVFISGYLSKKPQNVLKNFKNLLIPYVLGYTLTWYSQIWLGRSVDYEILRPTGSVMWYILALFIYRLTIEALGKIRFIVPLSILFALWAGTRPEFTTFLSSSRIVVFFPFFVAGYLWKSEYITAIRKFKGKWILVAISGVLLWAIPNYMIPNEMGIAIFRGNHGYQLCGLTDPQGVILRLLMYLVSFVVVYTMLALVPDIKLPLTYVGRHTMGIYFFHYPIMIIMNGLYILMLPAMNNVWVLLGVSLVFVLVLGSLPVDLLYTGVLNLIAFILIKKDKTVRDEGLEEEYDSEYDEYELLRRKKAIAELAATLDSESEQDEHVEKVNMDEDTPDHTSSDSHEGFSNVAGMELEIEEDNLDDIPDELIKGEEELSLEDLIQELEATTRTMDDNKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C6C2</accession>
    <name>A0A174C6C2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate diacid transcriptional activator CdaR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07450">
        <property type="protein sequence ID" value="CUO07450"/>
        <property type="gene ID" value="ERS852478_01784"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="283"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="450"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO07450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="516" mass="60762" checksum="E8E4ADE3E248F314" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CD03</accession>
    <name>A0A174CD03_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10697">
        <property type="protein sequence ID" value="CUO10697"/>
        <property type="gene ID" value="ERS852478_01863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO10697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="203" mass="23046" checksum="02C6A5BD2B1694B7" modified="2016-09-07" version="1">MNNNHVYDMIVVGEGLHIIQTFEPHPLYAVMEGLGYEHHTEQRSEAEFHVWFCRVEKNAGDSSAPFKPLALLNYPMIDEKLGQIAVDFWETTWQSEKRVLPYETLLLSLTNAVGAGRMRQAARELVKAYIHGVESAALDDVFELLAWNQGIGFFSSEIGPSALFQAYKLIKNGEKQGKSREDICSALREKFGEKNPEMQVLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CDW3</accession>
    <name>A0A174CDW3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO09915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070102125.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09915">
        <property type="protein sequence ID" value="CUO09915"/>
        <property type="gene ID" value="ERS852478_01838"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023387">
        <property type="entry name" value="DUF1653-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037135">
        <property type="entry name" value="DUF1653-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07866">
        <property type="entry name" value="DUF1653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1653" evidence="1">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO09915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="121" mass="14360" checksum="05169DB105C46DC6" modified="2016-09-07" version="1">MLRTREFCKKTVTEELRPGDVVQHFKRGMTNSDDHNAYLYKIICEAIHTETKEPMVVYQALYGDCATYVRPKEMFLEKVDTKKYPDATQEYRFEKYAGIPRLKSEKEIPRELKHSPSRFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CIY7</accession>
    <name>A0A174CIY7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in cyanobacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053630.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11768">
        <property type="protein sequence ID" value="CUO11768"/>
        <property type="gene ID" value="ERS852478_01899"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06260">
        <property type="entry name" value="DUF820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012296">
        <property type="entry name" value="Nuclease_put_TT1808"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008538">
        <property type="entry name" value="Uma2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05685">
        <property type="entry name" value="Uma2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO11768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="182" mass="21016" checksum="4838061ADE0DF071" modified="2016-09-07" version="1">MALLKEESYTIEDIYALPDGERAELIDGHIYYMAPPSYKHQKLVMELSAIIRNYIKQHKGTCEVLPAPFAVYLDEINNTYVEPDISVICDPNKLDDKGCKGAPDWIIEIVSPASRKMDYLLKLFKYHSAGVREYWIVDIAKNRITVYNFNHDYSIEEYSFTDTVKAGIYEDLSIDFSEINIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CJN8</accession>
    <name>A0A174CJN8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glucuronide carrier protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Glucuronide permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">uidB_2</name>
        <name evidence="6" type="ORF">BWLFYP14_02191</name>
        <name evidence="4" type="ORF">ERS852478_01942</name>
        <name evidence="5" type="ORF">GT728_10640</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000023">
        <property type="protein sequence ID" value="MZL33642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703574.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13167">
        <property type="protein sequence ID" value="CUO13167"/>
        <property type="gene ID" value="ERS852478_01942"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001927">
        <property type="entry name" value="Na/Gal_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00792">
        <property type="entry name" value="gph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="239"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO13167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL33642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="465" mass="51181" checksum="DA23D94236C97C9D" modified="2016-09-07" version="1">MEEKKYLKWYNKIGYGSGDIAGNVVYAFLTSFMMVYLTDSVGLAAGVVGTLIAVSKLFDGFTDIFFGSMIDKTHSKMGKAKPWMLYGYIGCAITLVCCFAIPVSFGTTAKYAWFFISYTLLNGVFYTANNIAYSALTSLITKNSKERVQMGSYRFIFAFSTSLLIQAITVGFVDKCGGDAAAWRTVAIIYAIIGLVINTISALSVKELPEEELNEGEVKDDNEKYGMVQAFKLLVKNKYYMMICGTYILQQLYGAMIGAGIYYMTWVLKNKNLFGQFAWAVNIPLIIALIFTPTLVGKWKGMYKLNLRGYVLAVIGRALVVIAGYMGSVPLMMAFTALAALGQGPWQGDMNAVIASCSEYTYLTQGKRIDGTMYSCTSLGVKIGGGIGTAVVGWMLEFSGYVGTNATQPQSALDMMQFMYLWLPLIFDVLIMFVLSRMNVEDANKKLKAEKEIAADEVTDASDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CRC5</accession>
    <name>A0A174CRC5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="2">3.2.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">glgX</name>
        <name evidence="2" type="ORF">ERS852478_02010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16111">
        <property type="protein sequence ID" value="CUO16111"/>
        <property type="gene ID" value="ERS852478_02010"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="143"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO16111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="631" mass="72998" checksum="A1E31DB2246E0C94" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D0D1</accession>
    <name>A0A174D0D1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTP cyclohydrolase 1 type 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02395</name>
        <name evidence="3" type="ORF">ERS852478_02050</name>
        <name evidence="4" type="ORF">ERS852523_00039</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO95296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX66024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707629.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2208"/>
    <dbReference type="EnsemblBacteria" id="CUO17316">
        <property type="protein sequence ID" value="CUO17316"/>
        <property type="gene ID" value="ERS852478_02050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95296">
        <property type="protein sequence ID" value="CUO95296"/>
        <property type="gene ID" value="ERS852523_00039"/>
    </dbReference>
    <dbReference type="GeneID" id="66492644"/>
    <dbReference type="eggNOG" id="COG0327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO17316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO95296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="260" mass="28754" checksum="23C6C02CD0BED167" modified="2016-09-07" version="1">MKAYELTSWLEKKYPSDAAEDWDNVGLLAGDDTNEISHVFLALDLTEETLAEAIEDGADMIITHHPMIFSGIKKINNHSFTGRKILTLIQKGIVYYAMHTNYDVLGMADLSADYTKMHDTTVLSVTEEREGEVQGFGRVGKLPREMTLREYAQLVKESLKLNDVKVYGNLDSMVKCAAVCTGSGKSMIKDVIKAGADVYVTGDIDHHTGIDTVAQGLALIDAGHYGTEYIFMDAMKKELTQAFPELKISCAEVKSPYTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D2D2</accession>
    <name>A0A174D2D2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">ERS852478_02071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecG family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO18016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707669.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18016">
        <property type="protein sequence ID" value="CUO18016"/>
        <property type="gene ID" value="ERS852478_02071"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34182">
        <property type="entry name" value="PTHR34182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO18016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="78" mass="8299" checksum="DB428A660E2B8C75" modified="2016-09-07" version="1">MQIIKIILSVIFIIDCIALTVVVLMQEGKQQGLGAIAGAAETYWGKNKGRSMEGGLVKATTIMGILFFVISVALNMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D2R1</accession>
    <name>A0A174D2R1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Uridine phosphorylase</fullName>
            <ecNumber evidence="5 10">2.4.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">udp</name>
        <name evidence="13" type="ORF">BWLFYP14_02808</name>
        <name evidence="12" type="ORF">ERS852478_02106</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>phosphate + uridine = alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:24388"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.3" evidence="5 10"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19743">
        <property type="protein sequence ID" value="CUO19743"/>
        <property type="gene ID" value="ERS852478_02106"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010058">
        <property type="entry name" value="Uridine_phosphorylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01718">
        <property type="entry name" value="Uridine-psphlse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="11">
        <location>
            <begin position="38"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO19743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX66434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="276" mass="30369" checksum="D921965E2FF2FD7D" modified="2016-09-07" version="1">MATDVSRENEKDGMIMKNYSEDVNRQYHIQVAKGEVGRYVILPGDPKRCVKIAQYFDNPVLIADNREYITYTGTLDGVKVSVTSTGIGGPSASIAMEELYRCGADTFVRIGTCGGMQTEIKSGDIVIATAAVRMEGTSREYAPIEYPAVANLDVTNALVEAAKEKGFIYHTGVVQSKDSFYGQHEPEAMPAGYELINKWEAWKRMGCLASEMESAALFIVAGKLRARMGSCLLVLANQEREKLGLENPVVHDTDMAIRVAVEAIRRMIKEDQGQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D4X0</accession>
    <name>A0A174D4X0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tyrocidine synthase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tycA</name>
        <name evidence="2" type="ORF">ERS852478_02087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200541.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19115">
        <property type="protein sequence ID" value="CUO19115"/>
        <property type="gene ID" value="ERS852478_02087"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO19115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="506" mass="57562" checksum="6C294F1DAAE9845E" modified="2016-09-07" version="1">MKTSILEYLEESARKYPDKTAFADEHTSCTFKELEQTARRIGTAIAKYFTPRNPVPVFMEKSVETIGVFMGAVYAGCFYVLMDTKQPASRLQQILGILDSDVIVTSEKYLKDLEKLEFKGKVLMAPDLADEQENEAVLNEIREQALDVDPLYGIFTSGSTGVPKGVVVGHRSVLDFIDCFTELFDITDKDVMGNQAPWDFDVSVKDIYSGLKTGATVQIIPKQLFSFPMKLIDYLIEREVTTLVWAVSALCIISTLNGFEYKVPDKIKKILFSGEAMPVKHLNIWRKYLPDVMYVNIYGPTEITCNCTYYIVDREFQPGDVLPMGKAFPNEKVFLLDEEDKLITEKNKNGELCVTGSALALGYYKNREQTAKVFVQNPLNDRYLEPMYRTGDLAYYNERGELCFATRKDFQIKHMGHRIELGEIEAAMDKVPEIVRSCCIFDTVKSKIVAFYEGDIERRPLAKALGQYVPAFMVPNVFRQVESMPLTKNGKIDRKALTAMYQEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D6U8</accession>
    <name>A0A174D6U8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV secretory pathway, VirB4 components</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200587.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21264">
        <property type="protein sequence ID" value="CUO21264"/>
        <property type="gene ID" value="ERS852478_02155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016628">
        <property type="entry name" value="ATPase_SAG2001_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015040">
        <property type="entry name" value="ATPase_SAG2001_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="294"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO21264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="817" mass="93104" checksum="D55257A27DF52447" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DBV7</accession>
    <name>A0A174DBV7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rsmI</name>
        <name evidence="9" type="ORF">BWLFYP14_02870</name>
        <name evidence="8" type="ORF">ERS852478_02210</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380442.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22943">
        <property type="protein sequence ID" value="CUO22943"/>
        <property type="gene ID" value="ERS852478_02210"/>
    </dbReference>
    <dbReference type="GeneID" id="66493401"/>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO22943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="283" mass="32470" checksum="56ED18AB6D166B0F" modified="2016-09-07" version="1">MSGKLYLCATPIGNLEDITLRVLRTLKEVDLIAAEDTRNSIKLLNHFDIKTPMTSYHEYNKIDKAYVLISKMQEGQNIALITDAGTPGISDPGEELAAMCYEAGIEVTSLPGPAACITALTLSGLPTRRFAFEAFLPADKKERKLILEELKNETRTIILYEAPHRLIRTLEELKETLGNRRMTLCRELTKRHETAFHTTIEELILYYQTEKPLGECVLVIEGRSRQEMEEEQKASWEKITIEEHMEIYENQGHSRKEAMKMVANDRGMTKRDVYQYLINKTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DFV8</accession>
    <name>A0A174DFV8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gmk_1</name>
        <name evidence="3" type="ORF">BWLFYP14_02866</name>
        <name evidence="2" type="ORF">ERS852478_02206</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200613.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22826">
        <property type="protein sequence ID" value="CUO22826"/>
        <property type="gene ID" value="ERS852478_02206"/>
    </dbReference>
    <dbReference type="GeneID" id="66493397"/>
    <dbReference type="eggNOG" id="COG0194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO22826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="195" mass="22723" checksum="502871C1F0717885" modified="2016-09-07" version="1">MGKIFYIMGKSASGKDRIYSLLAAHKELNLKTLILYTTRPIRVGEQDGKNYYFVDDGKLEEFRKNGNLIEERAYHTVYGIWTYFTADDGQVNLADSDYLGIGTLESFKKMRKYYGEDAVCPVYVQVEDGERLSRALNREREQENPRYEEMCRRFIADQSDFSEENILNAGIEKRFQNINLDDCVKEIANYIKSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DLH6</accession>
    <name>A0A174DLH6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacterial protein of uncharacterized function (DUF961)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200661.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25018">
        <property type="protein sequence ID" value="CUO25018"/>
        <property type="gene ID" value="ERS852478_02262"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010365">
        <property type="entry name" value="DUF961"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038620">
        <property type="entry name" value="YdcP-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06125">
        <property type="entry name" value="DUF961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO25018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="108" mass="12426" checksum="EC6E5039C8249C3A" modified="2016-09-07" version="1">MEMKYVVPDMAQSFGTLEFAGESDHVFDRDKDNRRVFARRSYNLYSDVQKGENVVVEIPVQAGEKKFKYEQKVKLVNPKLYGRGYVIGDMGHTDYVLLADDIVAVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DTJ3</accession>
    <name>A0A174DTJ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UPF0122 protein BWLFYP14_02910</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BWLFYP14_02910</name>
        <name evidence="4" type="ORF">ERS852478_02363</name>
        <name evidence="5" type="ORF">ERS852523_00962</name>
        <name evidence="6" type="ORF">GT712_13730</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">2789STDY5834863</strain>
            <strain evidence="5 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPF0122 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP23338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000029">
        <property type="protein sequence ID" value="MZS90103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000072">
        <property type="protein sequence ID" value="VUX66634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704687.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000106.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1082"/>
    <dbReference type="EnsemblBacteria" id="CUO28803">
        <property type="protein sequence ID" value="CUO28803"/>
        <property type="gene ID" value="ERS852478_02363"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP23338">
        <property type="protein sequence ID" value="CUP23338"/>
        <property type="gene ID" value="ERS852523_00962"/>
    </dbReference>
    <dbReference type="GeneID" id="66494251"/>
    <dbReference type="eggNOG" id="COG2739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00245">
        <property type="entry name" value="UPF0122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007394">
        <property type="entry name" value="UPF0122"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40083">
        <property type="entry name" value="PTHR40083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04297">
        <property type="entry name" value="UPF0122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO28803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP23338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS90103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="107" mass="12757" checksum="1DA7C45B5216BA10" modified="2016-09-07" version="1">MEKFVEQGYLYDFYGELLTERQQQVYESVVLEDYSLSEVAEDLGISRQGVHDMIKRCNKTLEEYEQKLHLVEKFLNIRAQVKQIRVLAREYHSDEIVNISNEILEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DU39</accession>
    <name>A0A174DU39_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Phosphate acyltransferase</fullName>
            <ecNumber evidence="3 4">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">plsX</name>
        <name evidence="7" type="ORF">BWLFYP14_00166</name>
        <name evidence="5" type="ORF">ERS852478_02369</name>
        <name evidence="6" type="ORF">ERS852523_02030</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">2789STDY5834863</strain>
            <strain evidence="6 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PlsX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="3 4"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000019">
        <property type="protein sequence ID" value="CUP56122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993746.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000028.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1098"/>
    <dbReference type="EnsemblBacteria" id="CUO29003">
        <property type="protein sequence ID" value="CUO29003"/>
        <property type="gene ID" value="ERS852478_02369"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP56122">
        <property type="protein sequence ID" value="CUP56122"/>
        <property type="gene ID" value="ERS852523_02030"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO29003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP56122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="345" mass="36831" checksum="F64B3F10CE19652E" modified="2016-09-07" version="1">MAEQVRVVVDAMGGDNAPAEPVRAAVEAVTERQDIKVILTGKQEVIDKELAKYSGYPKNQIQVVNASQVIETAEPPVFAIRKKKDSSIVVGLNMVKKQEADAFVSSGSTGAVLVGGQVLVGRSKGVERPPLAPLIPTTKGVSLLIDCGANVDARPSHLVQFAKMGSIYMENVVGIKNPKVAIVNNGAEEEKGNALVKETFPLLKECKSINFIGSIEARDIPAGYADVVVCEAFVGNVILKLYEGVGSALVQKIKEGMMTSTRSKIGALLVKPALKETLKSFDATEYGGAPLLGLKGLVVKTHGSAKAIEIKHGIFQCVQFKQEKINEKIAERILEDQEVLKSGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DY28</accession>
    <name>A0A174DY28_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensory histidine kinase DcuS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200722.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29138">
        <property type="protein sequence ID" value="CUO29138"/>
        <property type="gene ID" value="ERS852478_02373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="2">
        <location>
            <begin position="526"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO29138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="636" mass="72301" checksum="7A2200169551EE3C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DYY9</accession>
    <name>A0A174DYY9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TIGR04002 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_00116</name>
        <name evidence="2" type="ORF">ERS852478_02420</name>
        <name evidence="3" type="ORF">GT728_01900</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL31987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704793.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30654">
        <property type="protein sequence ID" value="CUO30654"/>
        <property type="gene ID" value="ERS852478_02420"/>
    </dbReference>
    <dbReference type="GeneID" id="66494307"/>
    <dbReference type="eggNOG" id="COG4720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023812">
        <property type="entry name" value="CHP04002"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009825">
        <property type="entry name" value="ECF_substrate-spec-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07155">
        <property type="entry name" value="ECF-ribofla_trS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04002">
        <property type="entry name" value="TIGR04002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO30654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL31987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="178" mass="18540" checksum="F2C67C2651D4CCCD" modified="2016-09-07" version="1">MSELTAKENIKTADTVKRITATAVMAALTTLMTAYIFHIPVGVNGGYVHLGDTMIYLAAAFLPLPYACAAGAIGGGLADLLTAPVWAPATIIIKMLICLPFSSKGTKLVTKRNVVALFLAFAISATGYYIAEGIMFGFTASFFTSVSGSIVQSGGSAIMFVIIGTALDKIGFKTNIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DZW2</accession>
    <name>A0A174DZW2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type III pantothenate kinase</fullName>
            <ecNumber evidence="6">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">coaX</name>
        <name evidence="9" type="ORF">BWLFYP14_00101</name>
        <name evidence="7" type="ORF">ERS852478_02435</name>
        <name evidence="8" type="ORF">GT712_04180</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO31053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704815.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000128.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31053">
        <property type="protein sequence ID" value="CUO31053"/>
        <property type="gene ID" value="ERS852478_02435"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO31053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS88308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="254" mass="27147" checksum="7FAC66007B4282C7" modified="2016-09-07" version="1">MILAIDVGNTNIVVGCIDDRKTYFIERLSTNRTKTELEYAVDLKNVLDIYHIKKTEIEGCIISSVVPQITNIVKLAAEKILKKNAIVLGPGVKTGLNIMMDNPGQLGADQVADAVAGIAGYPVPLILIDMGTATTASVVNSKKQYVGGMILPGVGVSLDALTARASQLSGISIDAPRHVIGKNTIECMKSGVLYSNAAALDGIIDRIEEELGEKATVVATGGLAKKIVPHCKREIILDEELLLRGLLIIYEKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DZX5</accession>
    <name>A0A174DZX5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MBL fold metallo-hydrolase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Metallo-hydrolase YycJ</fullName>
            <ecNumber evidence="4">3.-.-.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yycJ</name>
        <name evidence="4" type="ORF">BWLFYP14_00144</name>
        <name evidence="2" type="ORF">ERS852478_02392</name>
        <name evidence="3" type="ORF">GT712_04525</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704729.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29756">
        <property type="protein sequence ID" value="CUO29756"/>
        <property type="gene ID" value="ERS852478_02392"/>
    </dbReference>
    <dbReference type="GeneID" id="66494279"/>
    <dbReference type="eggNOG" id="COG1235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="11"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO29756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS88376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="264" mass="29395" checksum="5A658F2609E1C9C2" modified="2016-09-07" version="1">MRLCSIASGSSGNCIYVGSDNTHLLVDVGISGKRVEQGLNSLELTGKDIDGILITHEHSDHIKGLGVIARKHQIPVYATEGTVEALSHMNLGKMPEGIFREIHEDEPFEINDLTVNPFTIPHDAAQPVGYRVECGEHSVGIATDLGKYNEYIVGNLQNLDALLLEANHDIRMLQVGKYPYYLKQRILGDRGHLSNENAGRLLCRLLHDNMKGIFLGHLSRENNYEELAYETVCSEVTLGDNPYKSRDFRIQVAQRDCISEVITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E6K9</accession>
    <name>A0A174E6K9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Site-specific tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993990.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32069">
        <property type="protein sequence ID" value="CUO32069"/>
        <property type="gene ID" value="ERS852478_02452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="107"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO32069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="247" mass="29232" checksum="911EAC14CA938CF5" modified="2016-09-07" version="1">MILEEYIFTSCFLNDIQGLIEQKKQSGYIYDSAKYILIQFDKFCVENHIDRAIITKELSDTWLSYHADEAKSRRASRMSVLRQLVQYMNSQGSECYIPSKFSAKSYRVPYVMNEREIREFFTVADDYIPKVNADRFSILAEEYKVLFRFIYCCGLRVSEARKLKLEDIDFERKTALILRSKGDKDRLIYIADDVCNMCLDMLDLLHDKYHFYSEYLFPSSDPNTPLQVASINKKFQEFCNNIVYICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E7U8</accession>
    <name>A0A174E7U8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Anaerobic sulfatase-maturating enzyme homolog YdeM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ydeM</name>
        <name evidence="9" type="ORF">BWLFYP14_00518</name>
        <name evidence="8" type="ORF">ERS852478_02523</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000004">
        <property type="protein sequence ID" value="VUX62647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33861">
        <property type="protein sequence ID" value="CUO33861"/>
        <property type="gene ID" value="ERS852478_02523"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024025">
        <property type="entry name" value="SCIFF_rSAM_maturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01384">
        <property type="entry name" value="thioether_bond_formation_requi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03974">
        <property type="entry name" value="rSAM_six_Cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="93"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO33861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX62647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="455" mass="52124" checksum="3EE66D5D7148E77C" modified="2016-09-07" version="1">MSLIHRYKSNGFNIVLDINSGCIHLVDEVTYEVLPYLEEGLGTEAIAEKLENKYNREDIETSVRECNKLKEDGMLFTKDVYENVIEEFSNNRQTVVKALCLHIAHDCNLACRYCFAEEGEYHGRRALMSYEVGKKALDFLIANSGSRKNLEVDFFGGEPLMNWQVVKDLVKYGREQEKLHNKKFRFTLTTNGVLLNDEVMEFCNKEMGNVVLSVDGRKEVHDYMRPFRKGAGSYDLIMPKFQKFAESRNQDKYYVRGTFTHHNLDFSKDVLHLADLGFKQISVEPVVAADTEEYAIREEDIPQIMEEYDTLAKEMIKREKEGKGFNFFHFMIDLTGGPCVYKRLSGCGSGTEYLAVTPWGDFYPCHQFVGEEQYLMGNVDEGITKPEIQKEFGGCNVYTKKDCKDCFARFYCSGGCAANAFHFQGDIKGNYEIGCELQRKRVECAIMIKAALACD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EEM4</accession>
    <name>A0A174EEM4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Predicted outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_02551</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003060618.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35178">
        <property type="protein sequence ID" value="CUO35178"/>
        <property type="gene ID" value="ERS852478_02551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019931">
        <property type="entry name" value="LPXTG_anchor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041033">
        <property type="entry name" value="Prealbumin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041100">
        <property type="entry name" value="TQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17802">
        <property type="entry name" value="SpaA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18202">
        <property type="entry name" value="TQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50847">
        <property type="entry name" value="GRAM_POS_ANCHORING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0572">Peptidoglycan-anchor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020663" evidence="6">
        <location>
            <begin position="30"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="988"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="GRAM_POS_ANCHORING" evidence="7">
        <location>
            <begin position="979"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="930"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="930"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO35178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1016" mass="111925" checksum="0E8D60D16B1FFB48" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EJG5</accession>
    <name>A0A174EJG5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="10">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 14" type="primary">ileS</name>
        <name evidence="14" type="ORF">ERS852478_02626</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO37781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200814.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37781">
        <property type="protein sequence ID" value="CUO37781"/>
        <property type="gene ID" value="ERS852478_02626"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="19"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="13">
        <location>
            <begin position="690"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="10">
        <location>
            <begin position="603"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO37781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1051" mass="121117" checksum="BCA2CE86CF390A78" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EKH6</accession>
    <name>A0A174EKH6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NfeD family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">NfeD-like C-terminal, partner-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BWLFYP14_00908</name>
        <name evidence="4" type="ORF">ERS852478_02645</name>
        <name evidence="5" type="ORF">ERS852523_02304</name>
        <name evidence="7" type="ORF">GT712_04955</name>
        <name evidence="6" type="ORF">GT728_06995</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">2789STDY5834863</strain>
            <strain evidence="5 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 13">BIOML-A1</strain>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000023">
        <property type="protein sequence ID" value="CUP64329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000012">
        <property type="protein sequence ID" value="MZL32952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000007">
        <property type="protein sequence ID" value="MZS88453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707795.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000055_gene1900"/>
    <dbReference type="EnsemblBacteria" id="CUO38293">
        <property type="protein sequence ID" value="CUO38293"/>
        <property type="gene ID" value="ERS852478_02645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP64329">
        <property type="protein sequence ID" value="CUP64329"/>
        <property type="gene ID" value="ERS852523_02304"/>
    </dbReference>
    <dbReference type="GeneID" id="66492692"/>
    <dbReference type="eggNOG" id="COG1585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="51"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO38293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP64329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL32952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS88453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX63430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="144" mass="15682" checksum="A2B180D97EF74243" modified="2016-09-07" version="1">MQPLIWLGILALLLVVEAITAGLTTIWFAGGALVAAIACYAGANLTVQILLFLCVSLVLLIFTRPLAMKYFNKETIQTNANSLIGKKAVVIQEIDNLAQTGQVRINDIEWTARSADDEKIGEGTVVTIEEIRGVKLIVKQNKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EV82</accession>
    <name>A0A174EV82_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore cortex biosynthesis protein YabQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200848.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40429">
        <property type="protein sequence ID" value="CUO40429"/>
        <property type="gene ID" value="ERS852478_02706"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019074">
        <property type="entry name" value="YabQ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09578">
        <property type="entry name" value="Spore_YabQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO40429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="152" mass="17705" checksum="464C56581BC70480" modified="2016-09-07" version="1">MSAFIHHELLLLLRTIAVGAVLLLCYDLLAAFRNVFAHSDKAVGTEDILYWLCCAFFVFSEIYRSNEGILRFFMVLGFLSGAYICNRVLGDIFVKCCTKLMEIPVIIIKFLIKWLLFPVKRCKLLWYKAYKCAKKGRLANWVILRKGRKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EYE4</accession>
    <name>A0A174EYE4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_00367</name>
        <name evidence="2" type="ORF">ERS852478_02768</name>
        <name evidence="3" type="ORF">ERS852523_02703</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000030">
        <property type="protein sequence ID" value="CUP75625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000026_gene1014"/>
    <dbReference type="EnsemblBacteria" id="CUO42481">
        <property type="protein sequence ID" value="CUO42481"/>
        <property type="gene ID" value="ERS852478_02768"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP75625">
        <property type="protein sequence ID" value="CUP75625"/>
        <property type="gene ID" value="ERS852523_02703"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0675">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO42481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP75625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX67522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="73" mass="8763" checksum="88376B9F1A809432" modified="2016-09-07" version="1">MNIAYRFRIYPTEEQKILLGKTFGCCRFLYNQMLNDKIREYKKTKKLLKNTPAMYKKEYSFLKEVDSLALANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZK6</accession>
    <name>A0A174EZK6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">serB</name>
        <name evidence="4" type="ORF">ERS852478_02783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200916.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42901">
        <property type="protein sequence ID" value="CUO42901"/>
        <property type="gene ID" value="ERS852478_02783"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011863">
        <property type="entry name" value="HSK-PSP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02137">
        <property type="entry name" value="HSK-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611863-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611863-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR611863-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO42901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="200" mass="22423" checksum="20280D690777700D" modified="2016-09-07" version="1">MYITCLDVEGVLVPEIWIAFAEASGIPELKKTTRDEPDYDKLMNWRLGILKEHGLGLKEIQDVITKIDPLPGAKEFLDELRSFSQVILISDTFTQFAAPLMEKLGRPTLFCNTLEVADNGEITGFKMRVEQSKLTTVKALQSIGFDTIASGDSYNDLSMIQASKAGFLFRSTDKIKADYPEIPAYEEYDELLAAIRNAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F375</accession>
    <name>A0A174F375_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C4-dicarboxylate transport protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Cation:dicarboxylase symporter family transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Glutamate-aspartate carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gltT</name>
        <name evidence="10" type="synonym">dctA</name>
        <name evidence="10" type="ORF">BWLFYP14_01048</name>
        <name evidence="8" type="ORF">ERS852478_02798</name>
        <name evidence="9" type="ORF">GT712_15295</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000036">
        <property type="protein sequence ID" value="MZS90397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200930.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43256">
        <property type="protein sequence ID" value="CUO43256"/>
        <property type="gene ID" value="ERS852478_02798"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="term" value="F:symporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
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        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO43256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS90397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX63684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="407" mass="42941" checksum="0871A78BAF2CA42B" modified="2016-09-07" version="1">MKKFYSWYKKHITAAIFTGLILGIITGLFLANRFEPVLAITSLIGSIYMNALNMMIFPLVFCSIIMGISSIGNARTTGKITAGAMIFFLCTTALASLAGLIIPRLIHLGEGVKFEMATSDIQATEMTSILDTIKNLIPSNPVAAFANGNMLQVLVFAVIVGFTLIAIGEKGTALLKVIDSCNEVCLKVISTVMYFTPIGVFCTIVPVVEANGTETIISLATQLIILYVAFFGFALVIYGGSVKFIGKESPVKFFKAMLPAALNAFGTCSSSATIPISKQRMEDEMGVSNKITSIAIPLGATVNMDAVSILMSFMIMFFANACGINVSISMMIIILLANVLLSVGTPGIPGGAIASFAALATMAGLPAGVMGVYISINTLCDMGATCVNVIGDMAGCVVLKEKIKLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F423</accession>
    <name>A0A174F423_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_16</name>
        <name evidence="7" type="ORF">ERS852478_02846</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
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        <property type="protein sequence ID" value="CUO44824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379914.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44824">
        <property type="protein sequence ID" value="CUO44824"/>
        <property type="gene ID" value="ERS852478_02846"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="103"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO44824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="307" mass="34290" checksum="3A1836D68192C866" modified="2016-09-07" version="1">MSQLGSITAEKEKQMDLERQRFQEVKAKMLAQQKYKRAARTAGHIVLNIVVALIVLLPLLYAVSIAFMPSGELFTLDMNILPKHPTLENFRQALQKVPLVRFVVNSFLVAGLITFGQIISCSLAAFSFSFLDFKGKNVLFMLVMATMMIPGEATIISNYLTVSGWNWLDSYQVLIVPYLTSAMGIFLFRQFYLTFPISLYESAKIDGCSNLRFIWQILMPLTKSAMGAMAVYTFINAWNMYMWPLLVTGSDKMRTVQIGIGMLDSVDSQSITLMIAGVVLIILPSISIFIAGQKQLIRGMFSGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FBX4</accession>
    <name>A0A174FBX4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase/IS protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02891</name>
        <name evidence="3" type="ORF">ERS852523_03876</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000069">
        <property type="protein sequence ID" value="CUQ08000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019161580.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000095.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000044_gene2040"/>
    <dbReference type="EnsemblBacteria" id="CUO46326">
        <property type="protein sequence ID" value="CUO46326"/>
        <property type="gene ID" value="ERS852478_02891"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ08000">
        <property type="protein sequence ID" value="CUQ08000"/>
        <property type="gene ID" value="ERS852523_03876"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="1">
        <location>
            <begin position="10"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO46326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ08000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="258" mass="30135" checksum="3F7010DA8EE14970" modified="2016-09-07" version="1">MTNQSTMDKLIEMRLTTMADAFRNQLNDPKFKEVPFEDQFGMLVDIEYSSRKNNRLKRLIKNAGFDQPEANIMDINYTSGRKLNKELIRRLATCEYISEHRNLFITGATGCGKTYMACAFGMEACKQYYNTKYIRLPDLLIDLEVARTDGNYKKVMAKYANPVVLILDEWLLLKPTESEQRDIFELLHRRRKKSSTIFCSQYEFEEWYDQLGGDDSPLADAIIDRIAHDSYRINITSIDAEHDISMREVYGLDKTLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FHH8</accession>
    <name>A0A174FHH8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO49171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706250.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49171">
        <property type="protein sequence ID" value="CUO49171"/>
        <property type="gene ID" value="ERS852478_02984"/>
    </dbReference>
    <dbReference type="GeneID" id="66495489"/>
    <dbReference type="eggNOG" id="ENOG502Z7T7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO49171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="354" mass="38924" checksum="096E9B2BD94DBA67" modified="2016-09-07" version="1">MTFYQELQLSSTGSKQLIRSTTDPKEKRRHILIYNFKVYLVMAFCVAVVSMYSKLTGSSNSVVGVTVLLAVLVLRQADFGIRTTHGLLSIAGIFGILMAGPRLANIVPPLAAFAVNAVCILLLMILGCHNVIMYNHSTFVLGYLLLLGYDVTGKEYTFRVIGLLVGMVICMIVFYKNQRNRAYRRTFLDLFREFDLKSARSRWYVKLTLIVSSAMLFMNLLGLPRAMWAGIACMSVCLPFTEDCIPRSVSRGMFNVVGCLLFIVLYLVLPKSMYPYIGMIGGIGVGYSAGYPWQTAFNTFGALSIAAGIFGMPAAIALRIGANVLGAAYTVICNKVTDKVAEYIGTNKCAENLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FKR4</accession>
    <name>A0A174FKR4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpG_2</name>
        <name evidence="9" type="synonym">atpG</name>
        <name evidence="10" type="ORF">ERS852478_03037</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201091.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50862">
        <property type="protein sequence ID" value="CUO50862"/>
        <property type="gene ID" value="ERS852478_03037"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO50862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="285" mass="31667" checksum="CBDC9A7CD15AD9EF" modified="2016-09-07" version="1">MASNMKAVKLRIKSVQSTMQITKAMELVASSKLRKAKERAEICRPYFTELHETLKEIARENTDFSSVYAKESSNNKTCYVVIAGDRGLAGGYNANLFKCLEASAEGKDYMVLPVGKKAVEYFRQREIEALTEQFAEVGSISVADCFEMANMLCTEFRKGTFGHIELCYTVFNSMLSQQPEVFSMLPMTDIREESGGKIETKNLILYEPDGETVFDAIVPEYLAGLVYGGICESTASELAARRMAMDAATSNAEEMIDQLNLYYNRARQASITQEITEIVAGAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FYK7</accession>
    <name>A0A174FYK7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002304353.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53640">
        <property type="protein sequence ID" value="CUO53640"/>
        <property type="gene ID" value="ERS852478_03114"/>
    </dbReference>
    <dbReference type="GeneID" id="56863493"/>
    <dbReference type="GeneID" id="66495700"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO53640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="62" mass="7516" checksum="AE703DD1BBD85FB5" modified="2016-09-07" version="1">MPRMSKKRKHELSFYLNDRGRVTYNELCRKCQHGCKQSFRAVVIDCPRYLSKRAKKKEEHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G8T8</accession>
    <name>A0A174G8T8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ftsX</name>
        <name evidence="14" type="ORF">BWLFYP14_00321</name>
        <name evidence="13" type="ORF">ERS852478_03216</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707359.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57269">
        <property type="protein sequence ID" value="CUO57269"/>
        <property type="gene ID" value="ERS852478_03216"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 13" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="12">
        <location>
            <begin position="59"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="11">
        <location>
            <begin position="202"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO57269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX67476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="301" mass="33783" checksum="364FEC06F8ABCA6C" modified="2016-09-07" version="1">MRPSTIWYTLKQGVKNIKRNWMFSLASIITMAACIFLFGIFFSIVNNVNNIAHKVEQEVPITVFFEEGTTNKQIKAIGKKIKARPEVEKIEYQSADEAWEEYKEQYFQGSEAADGFKDDNPLANSANYRVYMNDITKQSELVSYIQELKHVRKVNQSEEAAKTLGNINKLVSYISIAIIVLLLIISIFLISNTVSVGIAVRKEEIGIMKYIGATDAFVRAPFLLEGMVLGVVGAAVPLIVLYFCYNGAISYILTRFNVLTGVVDFIPVWQIYQTLLPISLGLGIGIGLIGSFFTTRKHLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G981</accession>
    <name>A0A174G981_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="11">IGPS</shortName>
            <ecNumber evidence="4 11">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">trpC</name>
        <name evidence="13" type="ORF">ERS852478_03230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TrpC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="4 11"/>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57676">
        <property type="protein sequence ID" value="CUO57676"/>
        <property type="gene ID" value="ERS852478_03230"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="12">
        <location>
            <begin position="5"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO57676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="266" mass="29801" checksum="DA9DF4C310D850D8" modified="2016-09-07" version="1">MKNILEEIAARTRERIAKEKSRISVSELENRIQEVNKNARQKITFLQALQKDGMSYICEVKKASPSKGLIAPDFPYLAIAKEYEQAGASAISCLTEPFYFQGADQYLREIAAAVQIPVLRKDFTVDEYMIYQAKSLGASAVLLICAILDDGELRAYRQLAKELGLDALVEAHDEYEVDRALNLGAEIVGVNNRDLRTFQVDMNNSIRLRKMAPDNVVFVSESGIRTPEDIRLLYEDKVDAVLIGETLMRSPNKKAALESLNGSPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GB22</accession>
    <name>A0A174GB22_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthetase [glutamine-hydrolyzing] 1</fullName>
            <ecNumber evidence="9">6.3.5.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnB_2</name>
        <name evidence="9" type="ORF">ERS852478_03249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO58089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201248.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58089">
        <property type="protein sequence ID" value="CUO58089"/>
        <property type="gene ID" value="ERS852478_03249"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="356"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO58089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="610" mass="70369" checksum="351C04101AFA5575" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GBQ9</accession>
    <name>A0A174GBQ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Predicted membrane protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Trimeric intracellular cation channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">yicG</name>
        <name evidence="11" type="ORF">BWLFYP14_00766</name>
        <name evidence="9" type="ORF">ERS852478_03299</name>
        <name evidence="10" type="ORF">GT728_14715</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO59873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000039">
        <property type="protein sequence ID" value="MZL34416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000019">
        <property type="protein sequence ID" value="VUX63026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704940.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59873">
        <property type="protein sequence ID" value="CUO59873"/>
        <property type="gene ID" value="ERS852478_03299"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="105"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO59873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL34416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX63026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="217" mass="23577" checksum="E9A4C55132B6F140" modified="2016-09-07" version="1">MDYQSIVTFVMEMAGSVAFAASGAMVGVERNMDIFGVSVLGVATAVGGGMIRDIVLGIIPPAVFTNPVYALVSVLASCIVFFIFYFKRELLQGHRRETYDKIMLAMDSVGLGIFTVVGVNTGIRQGYMDNVFLLVFLGTITGVGGGLLRDMMASVPPYIFVKHIYACASIIGAVVCVYMNRFVGNVQAMVVSSIVVVLIRYLAAHYRWNLPRLSPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GHM8</accession>
    <name>A0A174GHM8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.89</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Carnitine operon protein CaiE</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Gamma carbonic anhydrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yrdA</name>
        <name evidence="4" type="synonym">dapH</name>
        <name evidence="4" type="ORF">BWLFYP14_01442</name>
        <name evidence="1" type="ORF">ERS852478_03368</name>
        <name evidence="3" type="ORF">GT712_18820</name>
        <name evidence="2" type="ORF">GT728_19040</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">BIOML-A1</strain>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.89" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO62102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000079">
        <property type="protein sequence ID" value="MZL35211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000064">
        <property type="protein sequence ID" value="MZS91034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000033">
        <property type="protein sequence ID" value="VUX64588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703968.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000079.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62102">
        <property type="protein sequence ID" value="CUO62102"/>
        <property type="gene ID" value="ERS852478_03368"/>
    </dbReference>
    <dbReference type="GeneID" id="66494069"/>
    <dbReference type="eggNOG" id="COG0663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047200">
        <property type="term" value="F:tetrahydrodipicolinate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO62102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL35211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS91034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="167" mass="17824" checksum="356D08CC18FA283B" modified="2016-09-07" version="1">MDYKSVKISEDAKIARQSVVIGDVTIGRDSCVLHYAVIRGDDAPIVIGEESNVQENCTIHVSRNMPVHIGNNVTVGHNAVLHGCMIGDRTLIGMGAVVLDGARIGKDCIIGAGSLVTKNTVIPDGSLVMGSPAKIKRNLTWEEKLGNLENSKEYVSVSAEMQKQGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GII5</accession>
    <name>A0A174GII5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamine synthetase</fullName>
            <ecNumber evidence="4">6.3.1.2</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Type I glutamate--ammonia ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glnA_3</name>
        <name evidence="7" type="synonym">glnA_2</name>
        <name evidence="7" type="ORF">BWLFYP14_00740</name>
        <name evidence="4" type="ORF">ERS852478_03326</name>
        <name evidence="6" type="ORF">GT712_14975</name>
        <name evidence="5" type="ORF">GT728_14580</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">BIOML-A1</strain>
            <strain evidence="6 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000039">
        <property type="protein sequence ID" value="MZL34389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000034">
        <property type="protein sequence ID" value="MZS90336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000019">
        <property type="protein sequence ID" value="VUX62991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704905.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60770">
        <property type="protein sequence ID" value="CUO60770"/>
        <property type="gene ID" value="ERS852478_03326"/>
    </dbReference>
    <dbReference type="GeneID" id="66494382"/>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="3">
        <location>
            <begin position="105"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO60770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL34389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS90336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX62991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="440" mass="50094" checksum="DF6131D75CDB046F" modified="2016-09-07" version="1">MGNYTREEILQMAEEEDVEFIRLQFTDMFGTLKNIAITARELPRALDNRCIVDGSFIAGIAGESEPDMYLRPDLDTFAILPWRPQQGKVARLLCDIYCPDGTPHERSPRYILKKTAREAKKEGYTCLVDPECEFFLFHTDDNGVPTTVTHEKAGYLDVSPVDLGENARRDIVLNLEDMGIEVESSHHETAPAQHEVDFKYGEVRTIADRIMSFKMTVRTIAKRHGLHATFMPKPRAEVNGSGMHIHFSLFKDGRNVFVNPGNPQELSEEAYYFVGGLLAHSKEMALITNPIVNSYKRLVPGYEAPTELTWTKNNQNSLVRIPGSRGMETRIELRSPDAAANPYLVFAVCLAAGLDGINKKIYPTKSSSRELSETDQKTMKIENLPGNLNEAIDYFEQSDWIKEVLGTEFCKEYAAAKKKEWLRYTREISAWEIEEYLYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GV40</accession>
    <name>A0A174GV40_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bioD1</name>
        <name evidence="5" type="synonym">bioD</name>
        <name evidence="6" type="ORF">ERS852478_03459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201411.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65097">
        <property type="protein sequence ID" value="CUO65097"/>
        <property type="gene ID" value="ERS852478_03459"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO65097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="232" mass="25487" checksum="7C6640B6C54C1C5F" modified="2016-09-07" version="1">MSKAVFITGTGTDMGKTYLSGLIVKKLAQAGKNPAYYKAAMSGNDRRADGSLIPGDALFVKEMSGISQSLDDMCPYVYENAWSPHLASRVEGNPVDLDVVRRGFLKAANDYEYITMEGSGGILCPLCFDERKIQLEDVIREFELSSILVADAGLGTINSVVLTVEYMKAHSLPIKGIIFNHYHPGNIMEEDNIAMCQYMTGLPVIAKVQDNAKDLDIDADVLAEFYDEVKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H127</accession>
    <name>A0A174H127_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Competence protein ComM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">comM_2</name>
        <name evidence="3" type="ORF">ERS852478_03515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060666.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66780">
        <property type="protein sequence ID" value="CUO66780"/>
        <property type="gene ID" value="ERS852478_03515"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="213"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO66780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="514" mass="56524" checksum="BD7BB3B8568EA3D0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H294</accession>
    <name>A0A174H294_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1002 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Predicted secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_01586</name>
        <name evidence="3" type="ORF">ERS852478_03525</name>
        <name evidence="4" type="ORF">ERS852523_01600</name>
        <name evidence="5" type="ORF">GT728_12380</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
            <strain evidence="4 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP43416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000029">
        <property type="protein sequence ID" value="MZL33976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993380.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000119_gene3268"/>
    <dbReference type="EnsemblBacteria" id="CUO67169">
        <property type="protein sequence ID" value="CUO67169"/>
        <property type="gene ID" value="ERS852478_03525"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP43416">
        <property type="protein sequence ID" value="CUP43416"/>
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        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
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                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
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            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
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        <property type="gene ID" value="ERS852478_03735"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="33"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO73263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="137" mass="15994" checksum="728CA9AF0EE4DBAD" modified="2016-09-07" version="1">MKKIEIIERITDANGSISENILTSWEHKNQFIPEIIRFGELKIYLQEQIVKKNDSDVHLSKYEYDILLLLAKSPGRIFGKEMVYDLVWNEPYSGDYNVVMRHICNIREKIEDDPGQPLYIQTVRGVGYRFNGNLGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HGV7</accession>
    <name>A0A174HGV7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Excisionase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03696</name>
        <name evidence="3" type="ORF">GT712_11170</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO72135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000020">
        <property type="protein sequence ID" value="MZS89618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004613735.1">
        <property type="nucleotide sequence ID" value="NZ_WWVP01000101.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72135">
        <property type="protein sequence ID" value="CUO72135"/>
        <property type="gene ID" value="ERS852478_03696"/>
    </dbReference>
    <dbReference type="GeneID" id="61911905"/>
    <dbReference type="GeneID" id="64195734"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038148">
        <property type="entry name" value="Tn1545/Tn916_Xis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015122">
        <property type="entry name" value="Tn916-Xis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09035">
        <property type="entry name" value="Tn916-Xis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004323">
        <property type="entry name" value="Tn916-Xis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS89618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="67" mass="7967" checksum="8D38478AE3DFA44C" modified="2016-09-07" version="1">MNNTDVPIWEKYTLTIEEASKYFRIGEKKLRKLAEENIDAGWVIVNGNRIQIKRKQFEKIIDTLDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HHX7</accession>
    <name>A0A174HHX7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3 4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">gmd</name>
        <name evidence="6" type="ORF">ERS852478_03710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3 4"/>
    <dbReference type="EMBL" id="CYZN01000044">
        <property type="protein sequence ID" value="CUO72579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201500.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72579">
        <property type="protein sequence ID" value="CUO72579"/>
        <property type="gene ID" value="ERS852478_03710"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="5">
        <location>
            <begin position="6"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO72579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="350" mass="39448" checksum="5C646B780B62D563" modified="2016-09-07" version="1">MSKVALITGITGQDGSYLAEFLLEKGYEVHGIVRRASISNTARINHLIEKNVIKLHDGDLSDSSGLIRLVGEIRPDEIYNLAAQSHVQVSFDAPEYSGDVDALGVLRVLEAVRVCGLTKTCKVYQASTSELYGKVEEVPQKETTPFHPYSPYAVAKQYGFWMVKEYRDAYGMFAVNGILFNHESERRGENFVTRKITLAAGRIAEGLQDHLELGNMDSLRDWGYAKDYVECMWLIMQQEKPEDFVIATGVQHTVRDFTEKAFVANGMTIRWEGTGIDEKGYDVATGKMLVCVNPQWFRPTDVDNLWGDPTKAKTVLGWNPQKTSYEELVEIMAKNDRELAKREKAMKAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HL61</accession>
    <name>A0A174HL61_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ECF transporter S component</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF3816)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_03197</name>
        <name evidence="2" type="ORF">ERS852478_03750</name>
        <name evidence="3" type="ORF">ERS852523_04008</name>
        <name evidence="5" type="ORF">GT712_18780</name>
        <name evidence="4" type="ORF">GT728_19150</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000046">
        <property type="protein sequence ID" value="CUO73699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000075">
        <property type="protein sequence ID" value="CUQ11339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000080">
        <property type="protein sequence ID" value="MZL35232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000063">
        <property type="protein sequence ID" value="MZS91027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX66921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706068.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000080.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000079_gene2743"/>
    <dbReference type="EnsemblBacteria" id="CUO73699">
        <property type="protein sequence ID" value="CUO73699"/>
        <property type="gene ID" value="ERS852478_03750"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ11339">
        <property type="protein sequence ID" value="CUQ11339"/>
        <property type="gene ID" value="ERS852523_04008"/>
    </dbReference>
    <dbReference type="GeneID" id="66492555"/>
    <dbReference type="eggNOG" id="COG3275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO73699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ11339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL35232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS91027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="185" mass="19994" checksum="85D1768C13495484" modified="2016-09-07" version="1">MKTEKISVQKICMIAFAICINFVGGQIALFLKLPIYLDSIGTVFVAAVLGPFYGMLPNLLSGLLMGMTVDIYSLYYAPVGILLGFVTGLVYRKFQPKKWQIFPAALVITLPSTIISSCITAFLFGGITSSGSTVLVQLLAKTPLGMVGSCFVVQFITDYIDRVLCIAVAAVLITALRKSMKENFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HMS1</accession>
    <name>A0A174HMS1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cupin domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Uncharacterized conserved protein, contains double-stranded beta-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03825</name>
        <name evidence="3" type="ORF">GT712_15350</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000055">
        <property type="protein sequence ID" value="CUO76214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000037">
        <property type="protein sequence ID" value="MZS90407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993869.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76214">
        <property type="protein sequence ID" value="CUO76214"/>
        <property type="gene ID" value="ERS852478_03825"/>
    </dbReference>
    <dbReference type="GeneID" id="66494475"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO76214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="117" mass="12761" checksum="51B804B8F46AB33A" modified="2016-09-07" version="1">MANYTKTTIGKENRIELHEKLSLTGAEISLNELPAGANVPFVHSHKENEEIYGILSGNGKAIIDGEEISLSTGDWLKIAPTAKRQFFASDISGITYICIQVKENSLEHFTAEDAVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JDT7</accession>
    <name>A0A174JDT7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA (Adenine(22)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.217</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trmK</name>
        <name evidence="3" type="ORF">BWLFYP14_02394</name>
        <name evidence="1" type="ORF">ERS852478_02051</name>
        <name evidence="2" type="ORF">ERS852523_00038</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.217" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO95269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX66023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707630.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000026.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2207"/>
    <dbReference type="EnsemblBacteria" id="CUO17356">
        <property type="protein sequence ID" value="CUO17356"/>
        <property type="gene ID" value="ERS852478_02051"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95269">
        <property type="protein sequence ID" value="CUO95269"/>
        <property type="gene ID" value="ERS852523_00038"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006901">
        <property type="entry name" value="TrmK"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018637">
        <property type="entry name" value="TrmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO17356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO95269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="235" mass="26675" checksum="29B64290CF9DF985" modified="2016-09-07" version="1">MQLSLRLSAIAGLVTRGNRLVDVGCDHGYLPVSLYLDGKIPGAIAMDVRKGPLSRAQEHISQYGLDAYIETRLSDGLEALKPGEGDTLVIAGMGGPLMERILTDGAEVRESFREMILQPQSDIPHFRRFVRKIGWQITEEEMVLEDGKFYPMMKVIHGEKMHISEDTPYTLDEWFGGMLLERKHPVLREYLERELRIRNEILDRLKNAPNAEKRAGEIEEEKQAVIAALEEYEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MF19</accession>
    <name>A0A174MF19_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rplN</name>
        <name evidence="9" type="ORF">BWLFYP14_00265</name>
        <name evidence="6" type="ORF">ERS852478_01667</name>
        <name evidence="7" type="ORF">ERS852523_01285</name>
        <name evidence="8" type="ORF">GT728_04740</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">2789STDY5834863</strain>
            <strain evidence="7 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707265.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2974"/>
    <dbReference type="EnsemblBacteria" id="CUO02920">
        <property type="protein sequence ID" value="CUO02920"/>
        <property type="gene ID" value="ERS852478_01667"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33357">
        <property type="protein sequence ID" value="CUP33357"/>
        <property type="gene ID" value="ERS852523_01285"/>
    </dbReference>
    <dbReference type="GeneID" id="66496130"/>
    <dbReference type="eggNOG" id="COG0093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO02920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP33357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL32526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX67424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="122" mass="13357" checksum="B803FFCBDA3FECDB" modified="2016-09-07" version="1">MIQQETRLKVADNTGAKEILCIRVMGGSTRRYASIGDTIVATVKDATPGGVVKKGDVVKAVVVRTKKGARRKDGSYIRFDENAAVIIKDDLTPRGTRIFGPVARELREKKFMKIVSLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MF97</accession>
    <name>A0A174MF97_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rpmC</name>
        <name evidence="10" type="ORF">BWLFYP14_00263</name>
        <name evidence="6" type="ORF">ERS852478_01665</name>
        <name evidence="7" type="ORF">ERS852523_01287</name>
        <name evidence="9" type="ORF">GT712_08950</name>
        <name evidence="8" type="ORF">GT728_04730</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994114.1">
        <property type="nucleotide sequence ID" value="NZ_JADPFJ010000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2976"/>
    <dbReference type="EnsemblBacteria" id="CUO02858">
        <property type="protein sequence ID" value="CUO02858"/>
        <property type="gene ID" value="ERS852478_01665"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33427">
        <property type="protein sequence ID" value="CUP33427"/>
        <property type="gene ID" value="ERS852523_01287"/>
    </dbReference>
    <dbReference type="GeneID" id="66496128"/>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO02858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP33427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL32524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX67422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="69" mass="7889" checksum="FF15B5FBAA53C639" modified="2016-09-07" version="1">MKINKFVEDLKAKSAAELNEELVAAKKELFNLRFQNATNQLENTSRIKEVRKNIARIQTVITEQANASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174N7V1</accession>
    <name>A0A174N7V1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02324</name>
        <name evidence="2" type="ORF">ERS852523_01617</name>
        <name evidence="3" type="ORF">GT712_12740</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP43816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000025">
        <property type="protein sequence ID" value="MZS89914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705589.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26984">
        <property type="protein sequence ID" value="CUO26984"/>
        <property type="gene ID" value="ERS852478_02324"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP43816">
        <property type="protein sequence ID" value="CUP43816"/>
        <property type="gene ID" value="ERS852523_01617"/>
    </dbReference>
    <dbReference type="GeneID" id="66494441"/>
    <dbReference type="eggNOG" id="ENOG5033RPH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO26984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP43816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS89914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="127" mass="15093" checksum="C99E921842484F82" modified="2016-09-07" version="1">MKITEELLNEMKIKDENFSDGLIKPDGDYVRIPRGHLHGMMELLPWTENEIWKMIPDDDSPLFWLIEKTGCVLTDYNNSIGMKMTPAQQTVFDMMRKHGVLTDDYYDLTKQREKVREAREQKENRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174P7S7</accession>
    <name>A0A174P7S7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rpmF</name>
        <name evidence="9" type="ORF">BWLFYP14_00159</name>
        <name evidence="5" type="ORF">ERS852478_02376</name>
        <name evidence="6" type="ORF">ERS852523_02023</name>
        <name evidence="8" type="ORF">GT712_04600</name>
        <name evidence="7" type="ORF">GT728_02160</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000019">
        <property type="protein sequence ID" value="CUP55956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL32037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704709.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1105"/>
    <dbReference type="EnsemblBacteria" id="CUO29225">
        <property type="protein sequence ID" value="CUO29225"/>
        <property type="gene ID" value="ERS852478_02376"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP55956">
        <property type="protein sequence ID" value="CUP55956"/>
        <property type="gene ID" value="ERS852523_02023"/>
    </dbReference>
    <dbReference type="GeneID" id="66494264"/>
    <dbReference type="eggNOG" id="COG0333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044957">
        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO29225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP55956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL32037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS88391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="60" mass="6885" checksum="5E36FE76FDD11FA3" modified="2016-09-07" version="1">MSICPKNKSSKARRDKRRANWKMSAPNLVKCSKCGELMMPHRVCKACGSYNKKEIIKVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174S2Q7</accession>
    <name>A0A174S2Q7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02444</name>
        <name evidence="4" type="ORF">ERS852523_03282</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
            <strain evidence="4 6">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO31321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000044">
        <property type="protein sequence ID" value="CUP92214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381449.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1171"/>
    <dbReference type="EnsemblBacteria" id="CUO31321">
        <property type="protein sequence ID" value="CUO31321"/>
        <property type="gene ID" value="ERS852478_02444"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP92214">
        <property type="protein sequence ID" value="CUP92214"/>
        <property type="gene ID" value="ERS852523_03282"/>
    </dbReference>
    <dbReference type="GeneID" id="66494330"/>
    <dbReference type="eggNOG" id="COG0425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019870">
        <property type="entry name" value="Se_metab_YedF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03527">
        <property type="entry name" value="selenium_YedF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="5"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO31321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP92214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="204" mass="22439" checksum="1587BDF0AAAE35FE" modified="2016-09-07" version="1">MKHEVNAMGKQCPIPVVMTKKVIDNAAVGDEIEILIDNETAVNNLSRLANKTGCTFVSEKLGDKKYQVKMAVKTEQTGGTLEEEEFVCEAPHKKVTVAVISSNVMGNGDDELGKILIKGFIYALSQMETHPDTILFYNGGAKLTTEDSESLEDLKKMEEEGVEILTCGTCLKHYGLMEKLMVGKVTDMYTIAERMTGADKVIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SLQ9</accession>
    <name>A0A174SLQ9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">rpsI</name>
        <name evidence="12" type="ORF">BWLFYP14_00865</name>
        <name evidence="8" type="ORF">ERS852478_03163</name>
        <name evidence="9" type="ORF">ERS852523_03518</name>
        <name evidence="11" type="ORF">GT712_16090</name>
        <name evidence="10" type="ORF">GT728_16535</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000053">
        <property type="protein sequence ID" value="CUP98684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000051">
        <property type="protein sequence ID" value="MZL34757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000041">
        <property type="protein sequence ID" value="MZS90538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000024">
        <property type="protein sequence ID" value="VUX63386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705974.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000094_gene767"/>
    <dbReference type="EnsemblBacteria" id="CUO55133">
        <property type="protein sequence ID" value="CUO55133"/>
        <property type="gene ID" value="ERS852478_03163"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP98684">
        <property type="protein sequence ID" value="CUP98684"/>
        <property type="gene ID" value="ERS852523_03518"/>
    </dbReference>
    <dbReference type="GeneID" id="66494517"/>
    <dbReference type="eggNOG" id="COG0103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO55133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP98684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL34757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS90538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX63386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="130" mass="14423" checksum="60E7CD95E701F8AB" modified="2016-09-07" version="1">MASAKFYGTGRRKKSIARVYLVPGTGKITINKRDIDEYFGLDTLKVIVRQPLAATETEGKFDVLVNVHGGGYTGQAGAIRHGVARALLQADNDYRPVLKAAGFLTRDPRMKERKKYGLKAARRAPQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WRX6</accession>
    <name>A0A173WRX6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">4Fe-4S ferredoxin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Succinate dehydrogenase iron-sulfur subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BWLFYP14_02541</name>
        <name evidence="6" type="ORF">ERS852478_00040</name>
        <name evidence="7" type="ORF">ERS852523_00727</name>
        <name evidence="9" type="ORF">GT712_07705</name>
        <name evidence="8" type="ORF">GT728_12825</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP15864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000031">
        <property type="protein sequence ID" value="MZL34061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380682.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1404"/>
    <dbReference type="EnsemblBacteria" id="CUN41860">
        <property type="protein sequence ID" value="CUN41860"/>
        <property type="gene ID" value="ERS852478_00040"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15864">
        <property type="protein sequence ID" value="CUP15864"/>
        <property type="gene ID" value="ERS852523_00727"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN41860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP15864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL34061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS88956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX66169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="324" mass="36555" checksum="0EB872FD4314EDA5" modified="2016-09-07" version="1">MQELINRAKELLADGTVARVLGWKAGDLPYNPEPAYFETEESLKDFVYNGFCGANLSKYMIEASKLEGKTLVCLKPCDTYSFNQLIKEHRVDREKAYIIGVGCKGKLDIERIRKQGIKGIESISGAEITDEAETLTIQTIYGEKTCAYKDAMLERCHVCKGKEHKIYDELIGESKDTKDADRFAEVEKIEAMSPEEKFAFFQSQLSKCIRCNACRNVCPACSCRKCVFDSNKFDSAQKANVDSFEEKMFHIIRAFHVAGRCTDCGECSRVCPQGIPLHLFNRKFIKDIDTFYGEYQAGEDSTSKGPLTNFTFEDVEPSIVAERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WSH9</accession>
    <name>A0A173WSH9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-iminoacetate synthase</fullName>
            <ecNumber evidence="7">4.1.99.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">thiH_1</name>
        <name evidence="7" type="ORF">ERS852478_00058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.1.99.19" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199482.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN42482">
        <property type="protein sequence ID" value="CUN42482"/>
        <property type="gene ID" value="ERS852478_00058"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036355">
        <property type="term" value="F:2-iminoacetate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024007">
        <property type="entry name" value="FeFe-hyd_mat_HydG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034428">
        <property type="entry name" value="ThiH/NoCL/HydG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43583">
        <property type="entry name" value="PTHR43583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43583:SF2">
        <property type="entry name" value="PTHR43583:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00319">
        <property type="entry name" value="Fe_hydrogenase_maturase_(HydG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03955">
        <property type="entry name" value="rSAM_HydG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="BATS" evidence="6">
        <location>
            <begin position="275"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN42482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="473" mass="53311" checksum="425406AFB6914349" modified="2016-09-07" version="1">MYNPKSLKAEEFISDEEIRETLAYADANKENVELIDQILAKAKECKGLTHREASVLLACPIPEKIQEMYDLAAEIKKEFYGNRIVLFAPLYLSNYCVNGCVYCPYHKKNQHIARKKLTQEEIVKEVTALQDMGHKRLAIEAGEDPINNPIEYILECIQTIYSIKHKNGAIRRVNVNIAATTVENYRKLKDAGIGTYILFQETYHKESYETLHPTGPKHNYAYHTEAMDRAMEGGIDDVGLGVLFGLELYRYEFAGLLMHAEHLEAVHGVGPHTISVPRIKHADDIDPSAFDNSISDEIFAKICALIRIAVPYTGMIISTRESKAVREKVLPLGVSQISGASRTSVGGYDVPETEDEVTSAQFDVSDQRSLDEIVNWLMGMGDIPSFCTACYRAGRTGDRFMSLCKSKQISNCCHPNALMTLMEYLQDYASPETKKVGLELIQKELENIPGEKIRKLTEEHLADIVNGQRDFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WT12</accession>
    <name>A0A173WT12_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferrous iron transport protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00062</name>
        <name evidence="5" type="ORF">GT712_07595</name>
        <name evidence="4" type="ORF">GT728_03130</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A1</strain>
            <strain evidence="5 7">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000005">
        <property type="protein sequence ID" value="MZL32213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380698.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN42613">
        <property type="protein sequence ID" value="CUN42613"/>
        <property type="gene ID" value="ERS852478_00062"/>
    </dbReference>
    <dbReference type="GeneID" id="66492870"/>
    <dbReference type="eggNOG" id="COG1918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN42613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="73" mass="8123" checksum="FB8E8B9CB47E9AE5" modified="2016-09-07" version="1">MKTLKEVHVGETVKVQKLTGEGPVKRRIMDMGITKGVEIYVRKVAPLGDPVEVTVRGYELSLRKADAEMIVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WV30</accession>
    <name>A0A173WV30_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclomaltodextrinase</fullName>
            <ecNumber evidence="3">3.2.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.54" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199499.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43449">
        <property type="protein sequence ID" value="CUN43449"/>
        <property type="gene ID" value="ERS852478_00091"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047798">
        <property type="term" value="F:cyclomaltodextrinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="7"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN43449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="582" mass="65663" checksum="965899E0A64C9BB4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WYB4</accession>
    <name>A0A173WYB4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703166.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000198.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44481">
        <property type="protein sequence ID" value="CUN44481"/>
        <property type="gene ID" value="ERS852478_00127"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033ZG8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN44481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="108" mass="13279" checksum="D847023CBDB81686" modified="2016-09-07" version="1">MNKTIYEAEFTKMVHDKMREANRFKEYERIPKNRIGGDYWNTYWTIRYMLRTIEDILAKGDKLVLLGFFTVEPKFYKEKKHVLEWKEQAKMCMRFQKDIRQSLNLVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X149</accession>
    <name>A0A173X149_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Int-Tn_1</name>
        <name evidence="4" type="ORF">ERS852478_00120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44285">
        <property type="protein sequence ID" value="CUN44285"/>
        <property type="gene ID" value="ERS852478_00120"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN44285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="226" mass="26172" checksum="D4CB08CEA9369340" modified="2016-09-07" version="1">MFSISTMVQQDNFLTYIKNSKYAYYYPLFVFMLETALRVGEVCGLTWDDVDLEHGFVNITHQLQYNNVGKDACQYQILTPKSKSGVRNVPLSNAARDALMEQMKNQIEMDKKTEIEIDGYKDFVFSNRQNKPFITQTIGRILNRIVDDYNSDIKKFGGTIEPLPHIHPHLLRHTSCSRMAEAGVDPRTLQDIMGHASMKMTMELYNHVTNERLTNEIQKLNNRRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X8W6</accession>
    <name>A0A173X8W6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00236</name>
        <name evidence="3" type="ORF">GT712_00280</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN47327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703337.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000083.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN47327">
        <property type="protein sequence ID" value="CUN47327"/>
        <property type="gene ID" value="ERS852478_00236"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50327GK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045723">
        <property type="entry name" value="DUF6077"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19554">
        <property type="entry name" value="DUF6077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN47327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS87565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="363" mass="39850" checksum="CD1E416ECF331861" modified="2016-09-07" version="1">MRELCLACAGFALEFIVFYAAGIVLVRILKVKGDCSLTFILGYLVYFAVFELVIVPMTLKWVSLTAAAYIWAGIMALVICAAVICTIKKQRRIRAGQTETCSGIFGSISEIWKNHSVMIILAGAVVLLQCLIVIFYEDTTVDAAYYVGTVSTSVYTDTLGRYNPFNGAIQKAFQARYVFSAYPMHNAVWCRLLGIHPIVQAKQVMSCMNVVTANLIIYQIGKRLFDGNRKKADLMLVFVCVLQLFCGTIYSSGTFFFTRSYEGKAILANIAIPSVLMCAVWYLQEKNSRNVWIILFVTAVSALTFSGSAIIFPIVIAAGMAPAAVMNKRFSGLVYCAVCMLPSALYAAVFFACRIGLLTLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XAX3</accession>
    <name>A0A173XAX3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plasmid recombination enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plasmid mobilization pre family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN48939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199529.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN48939">
        <property type="protein sequence ID" value="CUN48939"/>
        <property type="gene ID" value="ERS852478_00253"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001668">
        <property type="entry name" value="Mob_Pre"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01076">
        <property type="entry name" value="Mob_Pre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN48939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="429" mass="48805" checksum="A0C3A3A0D3F8D8DF" modified="2016-09-07" version="1">MARNDGIDRTVARNQDLGNPADVAKVQEHNEREKDSYSNQDIVPERTSLNVHFKAPTDDYVKMFEQMEQDGVISTRGLKPDAVKYGELVFDVNSAYFYNHGGYEFAKQFYADAYKAAAEIVGGEQYILSAVMHADERNRAMSEALGEDVYHYHLHVVYIPVVEKQILWSKRCKDEDLRGTVKEVITQVSRSKKWESKPVLDEDGNPMLNARGKKILRSSYSVLQDDFFHFMRVAGYTDLERGERGSTEEHLTVTQFKVQAEQQRLETVAGQVAQAEQSLEDAKAATAKQKKKLESLQKETKAAKTIALTVQDIEAMGKKATFGNNITLTPDECDTLKRYAVNGIIANADNKRLKEKLASAEKTVSIWKQRYEVVNEKYMELKQKAQPFLDALEIASEKVRAFINSILIRGKQTQEHEHPARKRGQDMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XD93</accession>
    <name>A0A173XD93_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN48847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN48847">
        <property type="protein sequence ID" value="CUN48847"/>
        <property type="gene ID" value="ERS852478_00250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045722">
        <property type="entry name" value="DUF6076"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19553">
        <property type="entry name" value="DUF6076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN48847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="368" mass="41662" checksum="30F26F9F6C024570" modified="2016-09-07" version="1">MNQELMTLDFWQDTVIYEGKTFPVGTLACDALNVPADTITKMNEQCKKINLLLGMLNAGQDTSALFPMAKEAALTMLEILSKTPPFSYMDIPKHRERIERVFTADNALKYVEFAIKAVTNSLPFEEVPKYADAVMLQRYTAVCGHLAYSLEEYQKAMLDFAEQSDGNEADRTAEGFAKMFGTYFPPEFSITEGNAWMSTLNNSVQYVSVIRPGEKVAKLVKRMHYVSFVGMFRSDLFEGLCVGHAPKKCKICGKWFLTTNARHTKYCGGYAPGDKLHRTCRQIGNLKGREQRELADDHPVKQIYEKRLNTINRYVKRGTLDADLAEVMKKLAKDKMLRALSNVAYAKGDYEKEMGQAALKKEAKLRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XFY5</accession>
    <name>A0A173XFY5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_00296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199555.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50210">
        <property type="protein sequence ID" value="CUN50210"/>
        <property type="gene ID" value="ERS852478_00296"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="418"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN50210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="519" mass="59368" checksum="D8DEF8F2DA278072" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XHJ1</accession>
    <name>A0A173XHJ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF based on E. rectale Gene description</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199547.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIOY010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49858">
        <property type="protein sequence ID" value="CUN49858"/>
        <property type="gene ID" value="ERS852478_00284"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZCII">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024539">
        <property type="entry name" value="DUF3877"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12993">
        <property type="entry name" value="DUF3877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN49858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="176" mass="20736" checksum="B471B7FEDE02EE72" modified="2016-09-07" version="1">MNYNRLETSLIDVIKEEQAKLGYMKEKISLYYPLSSLNHFFGCETDAAGMMEILKNFPSYIEEKFGEVAVSHRGDRFCFTVSEKASEYVHNNMKENEFIRALIELVGRHGCTIEEIKELFHSYSDKIITEPMDNEEFDVMIRFDDGSDPYYYCFKDEGCHIIYHRFLPEDYADFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y046</accession>
    <name>A0A173Y046_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.99.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mop_2</name>
        <name evidence="4" type="ORF">ERS852478_00488</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.99.7" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199671.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57043">
        <property type="protein sequence ID" value="CUN57043"/>
        <property type="gene ID" value="ERS852478_00488"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033727">
        <property type="term" value="F:aldehyde dehydrogenase (FAD-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN57043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="920" mass="99774" checksum="355ED852C4F7ED53" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y194</accession>
    <name>A0A173Y194_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">M18 family aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">apeA</name>
        <name evidence="11" type="ORF">ERS852478_00471</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199654.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56488">
        <property type="protein sequence ID" value="CUN56488"/>
        <property type="gene ID" value="ERS852478_00471"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN56488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="463" mass="51093" checksum="7407A0BDAC9A683A" modified="2016-09-07" version="1">MERRNAWLSYTEAEEKELEKAAKAYRNFLNAGKTERECVTQIVKEAREAGYEPLEEKTAKGEKLKAGDKIYTVGMKKIVALFHIGQDDIEEGMNILGAHIDSPRLDVKQNPLYEDTDLAYLDTHYYGGVKKYQWVTLPLAIHGVVVKKDGSVAEVNIGEDEEDPIVYITDLLIHLAGKQMQKKAAEVIEGENLDILIGSRPLKDLPDDKKKEAVKQNVLNILKEKYAIEEEDFLSAELEIVPAGKARECGLDRSMIAAYGQDDRVCAYTSLLAMLEMEAPKRTSCCLLVDKEEIGSVGATGMQSRFFENAVAELLDAMGCYSELKLRRAMRNSSMLSSDVSAGYDPSYGEAFEKKNAAYLGRGIVLNKFTGARGKSGSNDANAEYVARVRNIFDTHEIAFQTAELGKVDVGGGGTIAYIAALYGMEVIDSGVAVLSMHAPWEVTSKADVYEAKKAYKAFLLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y1D8</accession>
    <name>A0A173Y1D8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Formyltetrahydrofolate synthetase</fullName>
            <shortName evidence="6">FHS</shortName>
            <shortName evidence="6">FTHFS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">fhs</name>
        <name evidence="7" type="ORF">ERS852478_00509</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199687.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57714">
        <property type="protein sequence ID" value="CUN57714"/>
        <property type="gene ID" value="ERS852478_00509"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN57714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="561" mass="60151" checksum="9E843D23FD432A39" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YFA9</accession>
    <name>A0A173YFA9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Biofilm regulatory protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">brpA</name>
        <name evidence="5" type="ORF">ERS852478_00633</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199727.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61816">
        <property type="protein sequence ID" value="CUN61816"/>
        <property type="gene ID" value="ERS852478_00633"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="82"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN61816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="479" mass="51753" checksum="98836452D851FA7D" modified="2016-09-07" version="1">MAKPGKKKKVLFVLEIIVLLLFIGGLYVYGQISSRLDKIEQPELKKEKIVVNQEAPKMTGYKTYVLFGIDTRGEGSQYSAQNSDTMIIVSVNNDTKEVRMISVYRDTLLNVGDDTYTKANAAYALGGPEQAITMLNTNLDLDISDYATADFSALVEVIDDLGGLDIPLSYAEIEHMNNYCVETSKLTGKDYTPIEKPEPKPEDQEAIVGTYHLNGVQATSYCRIRYTASLDMGRTERQRRVLGMLFDKAKIAGLSSIFKIMDDVFPMVTTSLSKQDILGLIPTLIGYKFTDSTGFPQKFKFSNIKGSIIVPTDLENNVVELHKFLYDDQDYTPSSEVVARSNKILEIVGGESKLDDAAKTTTQDTDTTNANDTFVWSGDNTSGSTDNSGDYDNDYDNGGYDGGYDNGGGDYGGGGDYDNSGDDGSYDNGGDDTGSDTGGGDYDGGDDTGGDETGGDETGGDDGFSDDSAADSGASSEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YIF6</accession>
    <name>A0A173YIF6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HAMP domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Inner membrane protein ypdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ypdA_1</name>
        <name evidence="7" type="synonym">ypdA_2</name>
        <name evidence="6" type="ORF">ERS852478_00667</name>
        <name evidence="7" type="ORF">ERS852523_00679</name>
        <name evidence="9" type="ORF">GT712_03355</name>
        <name evidence="8" type="ORF">GT728_03615</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">2789STDY5834863</strain>
            <strain evidence="7 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">BIOML-A1</strain>
            <strain evidence="9 12">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN63912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP13937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578107.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000015_gene3739"/>
    <dbReference type="EnsemblBacteria" id="CUN63912">
        <property type="protein sequence ID" value="CUN63912"/>
        <property type="gene ID" value="ERS852478_00667"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13937">
        <property type="protein sequence ID" value="CUP13937"/>
        <property type="gene ID" value="ERS852523_00679"/>
    </dbReference>
    <dbReference type="GeneID" id="66493439"/>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="330"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN63912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP13937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL32304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS88150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="614" mass="71249" checksum="F4923727850CBB0F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YJS5</accession>
    <name>A0A173YJS5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-glyceraldehyde 3-phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yghZ</name>
        <name evidence="3" type="ORF">ERS852478_00675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199754.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64194">
        <property type="protein sequence ID" value="CUN64194"/>
        <property type="gene ID" value="ERS852478_00675"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="26"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN64194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="331" mass="37490" checksum="797F9737DD0FCE0A" modified="2016-09-07" version="1">MYQANEKRYETMKYHRCGASGLMLPELSLGLWHNFGDTGVYENMKQMCFTAFDNGITHFDLANNYGPQPGSAEENFGKILKEEFSAYRDELIVSTKAGYDMWPGPYGNWGSRKYLIASLDQSLKRLGLDYVDIFYHHRMDPETPLEETMEALAQIVRSGKALYVGISNYDGETMKRAADILEELHCPFIINQNRYNIFNRTIETNGLKQAAAERKKGIIAFSPLSQGMLTDRYLNGIPKDSRVNTDGRFLHADQFSEERLNSIRSLNAIAAERGESLAQMALKWILRDGIVTSVLIGASRPQQILENLKVLDSAPFSEEELKKIDECSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YLI4</accession>
    <name>A0A173YLI4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-xylose-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xylF</name>
        <name evidence="4" type="ORF">ERS852478_00682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64453">
        <property type="protein sequence ID" value="CUN64453"/>
        <property type="gene ID" value="ERS852478_00682"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016259" evidence="2">
        <location>
            <begin position="35"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_4" evidence="3">
        <location>
            <begin position="56"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN64453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="365" mass="39877" checksum="8A988D64BDD1BEE1" modified="2016-09-07" version="1">MKLYKTKKNCGKLLLGILAFCTGMILLTGCGSSSEQKQNKNEETAEENKEEDKVQIGLTVDSFVIERWIRDRDVFVATARELGAEVNVQDAGADVKEQISQIEYFINKQVDVIVVIARDCGALSDAIQKAQSAGIPVISYDRMVNNANTDLYISFDNRKVGEIMAQALVNALPQGGDVFMIQGSSSDNNVQMVKQGFDDMIADTELHVVYEANCDGWTAELAAGYVEEALEKYPHVKGIMCGNDDIASQVVQVLAENQLAGNVVVVGQDGDLAACQRIVEGTQYMTAFKPIEDLARKAAKYAVEMGSGKGVAELEDVTETVNDGTYEIPSCILEPTAVTKENIDKVIIEGGFHRRDEVYLNADYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YM94</accession>
    <name>A0A173YM94_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication-associated recombination protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rarA</name>
        <name evidence="4" type="ORF">ERS852478_00690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199764.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64713">
        <property type="protein sequence ID" value="CUN64713"/>
        <property type="gene ID" value="ERS852478_00690"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="51"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN64713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="439" mass="48684" checksum="845940E1EB1F089D" modified="2016-09-07" version="1">MDLFEYAKSKTLDRESPLASRLRPTTLDEVVGQQHIIGKNTLLYRAIKADKLTSVIFYGPPGTGKTTLAKVIANTTSAEFTQINATVAGKKDMEAVVKEAQQNLGMYGKKTILFIDEIHRFNKGQQDYLLPFVEDGTIILIGATTENPYFEVNAALISRSIIFELKSLEISEVKELILRAVNDKTKGMGNYKARIDEDALDFLADMAGGDARNALNAIELGILTTPRSEDGLIHITLDVASQCIQKRVVRYDKNGDNHYDIISAFIKSMRGSDPDAAVYYLAKMLYAGEDVKFIARRIMILASEDIGNADPQALCVAVAAAQAVERVGMPESQIILSQAVTYMACAPKSNSAVNAIFAAMDSVKRTKTTVPPHLQDAHYGGHEKLGHGIGYKYAHDYPNHYVHQQYLPTEIQGEHFYELSEMGYEKKLKEYQNKIKSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YPE3</accession>
    <name>A0A173YPE3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Coproporphyrinogen III oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_00688</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199763.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64658">
        <property type="protein sequence ID" value="CUN64658"/>
        <property type="gene ID" value="ERS852478_00688"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005911">
        <property type="entry name" value="YhcC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF1">
        <property type="entry name" value="PTHR11135:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01091">
        <property type="entry name" value="uncharacterized_CHP01210-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01212">
        <property type="entry name" value="TIGR01212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="19"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN64658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="308" mass="35266" checksum="34281AFD32BDB078" modified="2016-09-07" version="1">MTKWGEKPYHSLDYMLRERFGEKVYKVTLNGGMSCPNRDGKIGTRGCIFCSAGGSGDFAADAALSITDQIESQISILSQKRPIHKYIAYFQAYTNTYAPVEYLEKIFTEAISHPKIVALSIGTRPDCLSPEIVTLLSRLNKQKPVWIELGLQTIHESTARYIRRGYPLCVFDDAVKRLRKENIEVIVHTILGLPGENTADILETMEYLNHMDIQGIKLQLLHVLRGTDLAADYEKGLFQTYERDEYISLLINCLEHLRPDMIIHRITGDGPKDLLIAPLWASRKREILNMLHHRMKEEQSYQGRLFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YQA2</accession>
    <name>A0A173YQA2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thermostable beta-glucosidase B</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bglB_1</name>
        <name evidence="5" type="ORF">ERS852478_00715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65477">
        <property type="protein sequence ID" value="CUN65477"/>
        <property type="gene ID" value="ERS852478_00715"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="575"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN65477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="812" mass="90478" checksum="DFC9D560F38576FC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YSS4</accession>
    <name>A0A173YSS4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Carbamate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">arcC1_2</name>
        <name evidence="10" type="synonym">arcC1_1</name>
        <name evidence="10" type="ORF">BWLFYP14_01781</name>
        <name evidence="7" type="ORF">ERS852478_00740</name>
        <name evidence="8" type="ORF">ERS852523_00603</name>
        <name evidence="9" type="ORF">GT712_03055</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
            <strain evidence="8 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:10152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate metabolism; carbamoyl phosphate degradation; CO(2) and NH(3) from carbamoyl phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the carbamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP11836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706491.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000016_gene3682"/>
    <dbReference type="EnsemblBacteria" id="CUN66427">
        <property type="protein sequence ID" value="CUN66427"/>
        <property type="gene ID" value="ERS852478_00740"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11836">
        <property type="protein sequence ID" value="CUP11836"/>
        <property type="gene ID" value="ERS852523_00603"/>
    </dbReference>
    <dbReference type="GeneID" id="66493515"/>
    <dbReference type="eggNOG" id="COG0549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00996">
        <property type="reaction ID" value="UER00366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035975">
        <property type="term" value="P:carbamoyl phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04235">
        <property type="entry name" value="AAK_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="PTHR30409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000723">
        <property type="entry name" value="Carbamate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN66427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP11836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS88090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX64988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="310" mass="33378" checksum="9E682800B29D5099" modified="2016-09-07" version="1">MSEKITVVALGHRALGTTLPEQKIATKKAAKAVADLVEAGNRVVISHSNGPQVGMIHTAMNEFGKTHPDYTFAPMSVCSAMSQGYIGYDLQTAIRAELISRGIYKPVATILTQVVIDPYDDAFAEPEKIIGRVLTEEEAETEESKGNFVTKLADGTYKRILAAPKPQKIVELETIRTLVDAGQVVIAAGGGGIPVMEQGIDLHGASAIIEKDLSSGLLAQELNADTLLILTSVEKVSLNLGQDNEEYLNTISVDDAKKYMADNQFAPGSMLPKFEAGISFIEKGDNRRTIITDIAHAKDGYFEKTGTIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YSX6</accession>
    <name>A0A173YSX6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="11">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">rlmN</name>
        <name evidence="14" type="synonym">rlmN_1</name>
        <name evidence="13" type="ORF">ERS852478_00732</name>
        <name evidence="14" type="ORF">ERS852523_00611</name>
        <name evidence="16" type="ORF">GT712_03095</name>
        <name evidence="15" type="ORF">GT728_03830</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">2789STDY5834863</strain>
            <strain evidence="14 18">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="15 19 20" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 20">BIOML-A1</strain>
            <strain evidence="16 19">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP12042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578161.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000016_gene3674"/>
    <dbReference type="EnsemblBacteria" id="CUN66145">
        <property type="protein sequence ID" value="CUN66145"/>
        <property type="gene ID" value="ERS852478_00732"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12042">
        <property type="protein sequence ID" value="CUP12042"/>
        <property type="gene ID" value="ERS852523_00611"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="96"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="212"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="11">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN66145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUP12042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL32346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZS88098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="346" mass="39464" checksum="5056628495F711C5" modified="2016-09-07" version="1">MTDIKSMTIDELKKLMTTLGDKPFRAKQIYSWLHEHLVTSYDEMTNLSKSLREKLKEYPVTALKMVDVQTSRIDGTQKYLFRLSDGNVIESVLMRYKHGNSVCISSQVGCRMGCRFCASTIGGLTRCLLPSEMLDQIYRIQALTGERVSNVVVMGTGEPLDNYENLLRFIHILTEDGGLHISQRNLTVSTCGLVPKIYDLAKEKLQMTLALSLHAPNDVKRRELMPIANKYSMDEVLEACRYYFKETGRRITFEYSLVAGVNDSDEDARELSGRIRDMNCHVNLIPVNPIKERSFVRSTRQAVENFKIKLEKCGINVTIRREMGSDIDGACGQLRKSYMEKTESEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YVL4</accession>
    <name>A0A173YVL4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stage 0 sporulation protein A homolog</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">luxQ_1</name>
        <name evidence="12" type="ORF">ERS852478_00789</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199799.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68221">
        <property type="protein sequence ID" value="CUN68221"/>
        <property type="gene ID" value="ERS852478_00789"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="479"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="739"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN68221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="873" mass="99717" checksum="2EB4B43F86308383" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YVW6</accession>
    <name>A0A173YVW6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Small multi-drug export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_01750</name>
        <name evidence="2" type="ORF">ERS852478_00770</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026648283.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67593">
        <property type="protein sequence ID" value="CUN67593"/>
        <property type="gene ID" value="ERS852478_00770"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009577">
        <property type="entry name" value="Sm_multidrug_ex"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36007">
        <property type="entry name" value="PTHR36007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06695">
        <property type="entry name" value="Sm_multidrug_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN67593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX64926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="166" mass="18398" checksum="26BD653D9CF0FE67" modified="2016-09-07" version="1">MEALVHWFSQNLSQYISPEGAVFIISMIPLLELRGGLLAASLLKISAAKAIPLCIVGNIIPIPFILLFIRQIFKVLKKTKLFRGLVMKLEDRAMRKSDQVKKYEFWGLMLFVGIPLPGTGAWTGSLIASLLEIDIKKSSLAIFCGIIMATVIMYIVSYGLVGNLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YY83</accession>
    <name>A0A173YY83_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Resolvase, N terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_01726</name>
        <name evidence="3" type="ORF">ERS852478_00795</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199803.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68413">
        <property type="protein sequence ID" value="CUN68413"/>
        <property type="gene ID" value="ERS852478_00795"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="23"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="2">
        <location>
            <begin position="190"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN68413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="551" mass="64629" checksum="EEFA4DEBBEEFFEC3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YYX9</accession>
    <name>A0A173YYX9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">S8 family serine peptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Serine protease AprX</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aprX_1</name>
        <name evidence="10" type="synonym">aprX_2</name>
        <name evidence="10" type="ORF">BWLFYP14_01720</name>
        <name evidence="8" type="ORF">ERS852478_00801</name>
        <name evidence="9" type="ORF">GT728_12510</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000030">
        <property type="protein sequence ID" value="MZL34001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706397.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68710">
        <property type="protein sequence ID" value="CUN68710"/>
        <property type="gene ID" value="ERS852478_00801"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07478">
        <property type="entry name" value="Peptidases_S8_CspA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041365">
        <property type="entry name" value="CspB_prodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034045">
        <property type="entry name" value="Pep_S8_CspA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017310">
        <property type="entry name" value="Pept_S8A_subtilisin_clostridia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18425">
        <property type="entry name" value="CspB_prodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037894">
        <property type="entry name" value="Subtilisin_rel_CspABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="CspB_prodomain" evidence="7">
        <location>
            <begin position="4"/>
            <end position="91"/>
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            <end position="565"/>
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        </source>
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</entry>
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                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
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                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
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    </evidence>
    <sequence length="129" mass="15149" checksum="63069396618951CB" modified="2016-09-07" version="1">MRKYENFCNALSNMKDIYNYEEPYDNVVITGLVGLYEICFEQSWKMMKEILEIHGYAEGATGSPKIILKTAYKAGMIRDEEQWLRALQARNNVTHSYNQKIALGIIADAKEEFYQMFCELKTEIEENWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZA67</accession>
    <name>A0A173ZA67_9FIRM</name>
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                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    </evidence>
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            <dbReference type="EMBL" id="CUN72085.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUP68956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64165.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="137" mass="15071" checksum="A8AEC7B6C39CE87E" modified="2016-09-07" version="1">MENCIFCKIANGEIPAATLYEDENFRVILDLGPASKGHALILPKSHAANIYELSDEMAAKAMILAKKMATAMTAALKCDGFNIVQNNGECAGQTVFHFHMHLIPRYKGDQVGITWHPGELSDADKEEILLKVKEQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZG55</accession>
    <name>A0A173ZG55_9FIRM</name>
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        <submittedName>
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    </protein>
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        <name evidence="1" type="ORF">ERS852478_00950</name>
        <name evidence="2" type="ORF">ERS852523_01178</name>
        <name evidence="4" type="ORF">GT712_09560</name>
        <name evidence="3" type="ORF">GT728_01430</name>
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            <taxon>Eubacteriales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 6 7" key="1">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
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        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
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                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
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            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CUP29996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380138.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000090_gene2558"/>
    <dbReference type="EnsemblBacteria" id="CUN74105">
        <property type="protein sequence ID" value="CUN74105"/>
        <property type="gene ID" value="ERS852478_00950"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP29996">
        <property type="protein sequence ID" value="CUP29996"/>
        <property type="gene ID" value="ERS852523_01178"/>
    </dbReference>
    <dbReference type="GeneID" id="66493716"/>
    <dbReference type="eggNOG" id="ENOG5030FFS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN74105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP29996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL31894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="96" mass="11062" checksum="BCB7403918160D81" modified="2016-09-07" version="1">MEIGAMLDELREKALKDRNIWQELMDTRKAEQPLAAFCAKCRELGYQIYEMDLITAGEEFYATMRRSTNGGGENSPKLAGEDDFYELFFASLEEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZII4</accession>
    <name>A0A173ZII4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76041">
        <property type="protein sequence ID" value="CUN76041"/>
        <property type="gene ID" value="ERS852478_01009"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503039I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN76041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="58" mass="6557" checksum="20880A8D6D99114B" modified="2016-09-07" version="1">MKKRKLNYRFHNPNTAEVTADYLLKILIEANASKVEQAIQEAANELPEQMNGTEGHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZKR6</accession>
    <name>A0A173ZKR6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable D,D-dipeptide transport system permease protein ddpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddpC</name>
        <name evidence="7" type="ORF">ERS852478_01029</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580828.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76647">
        <property type="protein sequence ID" value="CUN76647"/>
        <property type="gene ID" value="ERS852478_01029"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN76647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="274" mass="29608" checksum="6C12B65BB74BF14E" modified="2016-09-07" version="1">MKLAKVFKENKQFTLFSILALVVVGVAVFAPQIAPYDPLDAVMLESLQAPSSAHPFGTDKLGRDLLSRVIFGTRTSLIMTLCLVAVIFVIGTFLGVIAGYFGGIVDGVIMRIADMMISFPGLVLAIAIAGMLGPNLVNAVISIAAVSWTKYARLARSMVLRVKKNLYIEAAVVNGTRTWKILLVHVLPNMVTQMVVTAAADIGTMMLELASLSFLGFGATAPTPEWGLMLNEGRTYMAKAPWLMIYPGIAIVICVVIFNMLGDSIRDVLDPRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZLP1</accession>
    <name>A0A173ZLP1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01376</name>
        <name evidence="3" type="ORF">ERS852478_01012</name>
        <name evidence="4" type="ORF">GT728_13540</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000034">
        <property type="protein sequence ID" value="MZL34200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707136.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76138">
        <property type="protein sequence ID" value="CUN76138"/>
        <property type="gene ID" value="ERS852478_01012"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9BV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN76138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="412" mass="48353" checksum="0272A1CFC5DA69D5" modified="2016-09-07" version="1">MKATRHNGRSGKNGTYNPRHNDRRFDLENSEHIDAGRVRENIYWDCYRGYTTMQNREEDSQDISFEKIECTFYQEHYGKYIEAQNERNARTRHTERNRSVEDLLKNNKTCPEETIFQIGTVEESVSYEILLAVVQDFTKQFTNRFGSHVHILDWALHLDEGTPHIHERHVFDCENKYGEICPQQEKALEELGIALPKPDKPKGRNNNRKQTFDAICRTMLFDITRKYGLHLEEEPSYGGRDYLEKQDYILFKQKEQMKNQTEILDTLTLKIEEVEALIDEVSDIAYDKAVEVVTDEVRVETHKEDIRLVEQSKAWVLSPERKASQKERTYAVSRLDGVITKITKAMQTAVKTIQTTLIKPEVKKVNTEQIKKKARSSILDRLAKAKITAEQENRERWEHEGRTKLGRNDMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZQS9</accession>
    <name>A0A173ZQS9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059039.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPC010000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78387">
        <property type="protein sequence ID" value="CUN78387"/>
        <property type="gene ID" value="ERS852478_01051"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017099" description="DUF4097 domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="68"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN78387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="272" mass="29929" checksum="DE97281AC83F5856" modified="2016-09-07" version="1">MKRWAKAWLAVGVGCCVCGAALTGIGVASGGSKYVKSADLNKMDGAAKKSDNEMVLEKTKLDDFDSADISMTDMNLQVVNSDDQYCYISYRASDQKKDPISYQVKDGKLRIQENNNDGKTYYHVDIGFLSGLLGEGTLTTDENVVTIYVPEGQKWKLADIKSDMSNILLNGCEIENGAVQTDSGDVFFKNCDFNNLKVKTDMGNLCFIGKEDVMRTWNIQMNTDMGDINVDDALTGKMVEDQDDCDISYTQKGTGGNLVIQTDSGNIRLKCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZS30</accession>
    <name>A0A173ZS30_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable tRNA sulfurtransferase</fullName>
            <ecNumber evidence="6">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">thiI</name>
        <name evidence="9" type="ORF">ERS852478_01069</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiI family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199911.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79044">
        <property type="protein sequence ID" value="CUN79044"/>
        <property type="gene ID" value="ERS852478_01069"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA U4 sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00342">
        <property type="entry name" value="TIGR00342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="8">
        <location>
            <begin position="62"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN79044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="393" mass="44487" checksum="E14BA3A27C8EDE01" modified="2016-09-07" version="1">MIFHAFLIKYAEIAIKGKNRYIFEDALVKQMNIALSKVEGEFEVKKEQGRIYVFCPEQYDYDETVEALQHVFGIVGICPVVIYEDQGFEQMAKDVVSYMKNCHPDYDGSFKVYTRRAKKSYPITSMEVSAELGGRILDEFPDASVDVHEPDLTLSVEIRDKIYVYSQTIKGAGGMPIGTNGKAMLLLSGGIDSPVAGYMIAKRGVKIDAVYFHAPPYTSERAKQKVVDLAKQVAKYSGPIRLHVVNFTDIQLYIYDQCPHDELTIIMRRYMMRIAEHFAKESRCLGLITGESIGQVASQTLQSLAATNEVCTLPVYRPVIGFDKQEIVERSWEIGTYETSIQPFEDCCTIFVAKHPVTKPNLNVIHRSETKLEEKIDELMKTALETVEIIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZSQ3</accession>
    <name>A0A173ZSQ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">graR_1</name>
        <name evidence="10" type="ORF">BWLFYP14_00327</name>
        <name evidence="9" type="ORF">ERS852478_01047</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060444.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78238">
        <property type="protein sequence ID" value="CUN78238"/>
        <property type="gene ID" value="ERS852478_01047"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN78238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX67482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="222" mass="25573" checksum="01EC10D8C7C8AD85" modified="2016-09-07" version="1">MYRIFIVEDDEIISEVLKKNLSSWGYDVSCAEDFSNIIQEFVRRDPQLVLLDLKLPFYNGFHWCEEIRRISQVPVIFISSAADNMNMVMAMSRGADDFIAKPFDMDVLTAKIQAILRRTYSFGTPGNVLEYKGIVLSPSRCTLTWNGNDIDLTKNELRILEILMEHAGKVVSRDAIMTKLWESDSFIDDNTLTVNITRLRRKLEKEGLKEFIITKKGLGYMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A6T9</accession>
    <name>A0A174A6T9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellin N-methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN84027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199961.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84027">
        <property type="protein sequence ID" value="CUN84027"/>
        <property type="gene ID" value="ERS852478_01207"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN84027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="222" mass="26116" checksum="5C94DD057BB78709" modified="2016-09-07" version="1">MRREQTLEEISDGKLYDSNDMVKADCHDCEGCCDCCQGMGDSVLLDPYDVYRLSAGLQKSAEQLLQEYLELGVTDGNILPHLRMTGVKEQCIFLNSEGRCHIHSIRPGFCRLFPLGRFYENGNFKYILQIHECPKTNRSKIKVKKWIDTPNLKNYEKFVNDWHYFLLDVQEVLYNAEDPDLIRNLNLFVVNRFYLKPYDQNQDFYIQFYERLKEGKELLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AB59</accession>
    <name>A0A174AB59_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <shortName evidence="8">PCK</shortName>
            <shortName evidence="8">PEP carboxykinase</shortName>
            <shortName evidence="8">PEPCK</shortName>
            <ecNumber evidence="4 8">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">pckA</name>
        <name evidence="9" type="ORF">ERS852478_01227</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="4 8"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN84675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199972.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84675">
        <property type="protein sequence ID" value="CUN84675"/>
        <property type="gene ID" value="ERS852478_01227"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PTHR30031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="242"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="443"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN84675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="534" mass="59232" checksum="304C6F61F2AD57F9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AIZ5</accession>
    <name>A0A174AIZ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxygen-independent coproporphyrinogen-III oxidase 2</fullName>
            <ecNumber evidence="5">1.3.99.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hemZ_1</name>
        <name evidence="5" type="ORF">ERS852478_01286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.3.99.22" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200004.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87869">
        <property type="protein sequence ID" value="CUN87869"/>
        <property type="gene ID" value="ERS852478_01286"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025288">
        <property type="entry name" value="DUF4080"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13311">
        <property type="entry name" value="DUF4080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="4">
        <location>
            <begin position="172"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN87869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="558" mass="65575" checksum="3F0FF0D34C93FAEC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174APE5</accession>
    <name>A0A174APE5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted HD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200033.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90462">
        <property type="protein sequence ID" value="CUN90462"/>
        <property type="gene ID" value="ERS852478_01363"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="20"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN90462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="168" mass="19158" checksum="495C6A4F91461261" modified="2016-09-07" version="1">MTVAEVVKKMVEYSKGDLHDINHFMKVYAYAKTIAEGENLSPEQQKLVEVTAVVHDIACPLCRVKYGNANGKHQEEESAALIEEFFAYSDLPKEFVDRVSYIVSHHHTITGIDGIDYQIMIEADYLVNADESDFSGNNVRNMLEKVFKTETGKFLLQSMYQKRLNAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ARR3</accession>
    <name>A0A174ARR3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Maltose transport system permease protein malG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">malG_2</name>
        <name evidence="7" type="ORF">ERS852478_01356</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200030.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90220">
        <property type="protein sequence ID" value="CUN90220"/>
        <property type="gene ID" value="ERS852478_01356"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN90220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="286" mass="31020" checksum="081BEA91AB800815" modified="2016-09-07" version="1">MVTKKTPKVVLTAVAIVIAAYILSPFYLVLINTFKNANGIVANPVSFAGASFAQFKTNISNVVNNSNFSFWSAFGTSATITVVSLVLLALFGGMAAWVICRNKTKWSTAIYMTFIASMTIPFQVVMLPLVSTFRDVGKFLGINMLQSIPGIVFAYCGFGGAMTVFILTGFIKGIPYELEEAAAIDGCSPEGTFFRIILPLLKPVIVTVTILNGMWIWNDYLLPSLMLGQNGKVKTLPVAVQAFVGSYVKQWDLILTAALLAMIPMIIVFLLAQKQIMNGMVEGAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ASZ6</accession>
    <name>A0A174ASZ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribose transport system permease protein rbsC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rbsC_2</name>
        <name evidence="7" type="ORF">ERS852478_01378</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN91029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379836.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91029">
        <property type="protein sequence ID" value="CUN91029"/>
        <property type="gene ID" value="ERS852478_01378"/>
    </dbReference>
    <dbReference type="GeneID" id="66494872"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN91029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="328" mass="34654" checksum="2AD43CC8CD921EDD" modified="2016-09-07" version="1">MENKNWKNLSVIQTIKSNMGILAGLVILCVVLSFTTSSFATVTNLFNVVRQITINLFLACGMTFVILLAGIDLSVGSVIAVSGCISAGLISWNGLPVYVGILGGILAGVVIGLINGYIVSSTNIPAFIVTLAMMNIGRGIARVYTKAQTISVLDDSYTFWGMGTIFGIPIQLYCIVAVIAVSSFILNKTKLGRHIYAVGGNKQAAEYSGINVKKVTFFVFVYSALLASLAGILTVGRTFTAMMTLGDGAEMDAISAVVLGGTSMNGGRGTIAGTVIGAIVIGVLKNGMNLLGIDSSWQYIVQGIVILIAVYIDWFKQTGFKFSRKIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AZI0</accession>
    <name>A0A174AZI0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93864">
        <property type="protein sequence ID" value="CUN93864"/>
        <property type="gene ID" value="ERS852478_01432"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN93864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="489" mass="55344" checksum="82CD31CDFF56C61A" modified="2016-09-07" version="1">MMDDTAFSEFLDESIPLWRDDPVMFFREVLNFEPDEWQAQAARDLAANPKVSIKSGQGVGKTGLEAAVFLWFVTCFPHPRIVATAPTKQQLHDVLWSEISKWMSKSELLSILLKWTKTYVYMVGEEKRWFGVARTATKPENMQGFHEDNMLFIVDEASGVADPIMEAILGTLSGANNKLLLCGNPTKTSGTFYDSHTRDRALYKCHTVSSMDSTRTNKENIDSLVRKYGWDSNVVRVRVRGEFPNQEDDVFIPLSIIEQCSSRLLELDDTDGMQFVSLGVDVARFGDDETIIYRNYHGHCKIVRNRRGQNLMATVGDIVQEFKKIYREHLAYEGKVYVQIDDTGLGGGVTDRLKEVRKEQKLYKMQVIPINAAEKIETDTAAGKDAAERYNNLTTAMWASMRDLLDNKQIVIEDDEQTIGQLSSRKYTMASNGKLEIEPKKEMKKRGLDSPDRADALALALYLGKIKKHTGSAPSVGTMKKLSKDNYWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B0J8</accession>
    <name>A0A174B0J8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF2634)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200098.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94591">
        <property type="protein sequence ID" value="CUN94591"/>
        <property type="gene ID" value="ERS852478_01454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020288">
        <property type="entry name" value="DUF2634"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10934">
        <property type="entry name" value="DUF2634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN94591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="150" mass="17576" checksum="428711C3F4531FFF" modified="2016-09-07" version="1">MADNNLYPVVDIPEYEEENEEYDTEYKPSVAWDLEKGDFVCESPFCMLKSEGLEAYKIWCVKAVSTERYSCLGYDDDIGAEMEDAMKEEDDTAVELAIERTIEEALMVNPRTESVEDFEFSWEPSVVYVKFTVYAIHWEKFDLEVTLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B980</accession>
    <name>A0A174B980_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_00975</name>
        <name evidence="1" type="ORF">ERS852478_01503</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704321.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96320">
        <property type="protein sequence ID" value="CUN96320"/>
        <property type="gene ID" value="ERS852478_01503"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SRT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN96320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX63489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="103" mass="11639" checksum="0CB077109307B775" modified="2016-09-07" version="1">MLKWQENFLAGESVKDPEKIKKKLNSGKPVLGIYLLTLAENPVNLMDIIPAAMLIQKSFYGICPKIIGMAKGKEEALEMVRSLIDEMYRETGTFATAEYIENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BJD1</accession>
    <name>A0A174BJD1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008688040.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99825">
        <property type="protein sequence ID" value="CUN99825"/>
        <property type="gene ID" value="ERS852478_01577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN99825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="248" mass="28942" checksum="CD538EAE896F4F4C" modified="2016-09-07" version="1">MARIMTRRKAIPKAIELLQCLPQTEEVVEVIQALKKYSSTPLDRWDAASVYEALDEWTESHNGIPPRIKECDSHKELPSHMVFEKLFGKTAREFLNDYYGEMEYVRIGRHGTRCVDDQYDFLEIFKNEFERIQPATSKIYDACRNPETPSWGTIARRCKVSSWSELVTLSGVEANCIRRRYDTYNIRNKLSVSQKTNLETDLTAHEQQEEKERFEALLIKTHDLTLQAENQKKAEKAVSKHTLRIGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BJD4</accession>
    <name>A0A174BJD4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable endopeptidase p60</fullName>
            <ecNumber evidence="5">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">iap_2</name>
        <name evidence="5" type="ORF">ERS852478_01592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00309">
        <property type="protein sequence ID" value="CUO00309"/>
        <property type="gene ID" value="ERS852478_01592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="4">
        <location>
            <begin position="815"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO00309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="938" mass="104583" checksum="90069AD1B490C9B8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BM36</accession>
    <name>A0A174BM36_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative accessory gene regulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00745">
        <property type="protein sequence ID" value="CUO00745"/>
        <property type="gene ID" value="ERS852478_01605"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006741">
        <property type="entry name" value="AgrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04647">
        <property type="entry name" value="AgrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00793">
        <property type="entry name" value="AgrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0673">Quorum sensing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO00745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="194" mass="21617" checksum="612ADC9F8655FB00" modified="2016-09-07" version="1">MWKKMAGRLFELQSRNGILEEKDRRLYEYAYGVLLGRVVIYLIIVILGIITGNWMEMIVFLLPFTVLRQYAGGIHLEKAGGCMAVSGILVLLCSLYLASAPAVIWQMRIIWFVAVGVIFIMAPVDASSKKLDAKEKKVYGMRARVILVIECAIAGVFSVIGYSLIVNGIMVAHIVLASGLILGWTKIFFDKELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BX30</accession>
    <name>A0A174BX30_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">V-type ATP synthase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200175.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05243">
        <property type="protein sequence ID" value="CUO05243"/>
        <property type="gene ID" value="ERS852478_01713"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_su_c/d_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_su_c/d_dom_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="SSF103486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO05243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="347" mass="41425" checksum="D3AC3D73FBEE4734" modified="2016-09-07" version="1">MGGVLSYSGLSTKIRAMQSRLTTMDQFEEILQLSDVTQVAAYLKRMPEYSSRWDALDENTLHRGQIEKLLKKSIFQNFSRIYHFANPEQRKFLDLYSKRYEIRVLKEVMTNIFDHRDTDPVDVSPYREFFRLHSNIDVDRITTCSTMEELISCLKGNEFYIPLSKIQEHETALLFDYGMALDLYYFTQIWNIRKKLFKGKDLEEITRTYGEKFDMLNLQFIQRSKRYYNMDPASIYALLIPVNYKLKKEEITALVEAPSYEEGRRIFQKTWYGNKYEQLTVANLEEFYNHIHRSILEKESHRNPYSVAVIYSYLYNKEHEVNRLTIAIECVRYGVQHDEAMRYICNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C0H7</accession>
    <name>A0A174C0H7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06367">
        <property type="protein sequence ID" value="CUO06367"/>
        <property type="gene ID" value="ERS852478_01749"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO06367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="56" mass="5869" checksum="BC2AC57334BD54B1" modified="2016-09-07" version="1">MRRGLGTGMAANGVPVDTVAQVLGHKETKATKQYISTDLQSLRCCTLDFDSLGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C1V6</accession>
    <name>A0A174C1V6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator SlyA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05885">
        <property type="protein sequence ID" value="CUO05885"/>
        <property type="gene ID" value="ERS852478_01733"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO05885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="145" mass="16693" checksum="9A69C0598C38E189" modified="2016-09-07" version="1">MNHYEAINDVLVNLFNEILDLEERALITGEYKNISVNDMHIINAVGIREQKNMSTVARELNVTVGTLTIAVNNLVKKGYIQRMRSQEDRRVVLISLTEQGKKAYYHHKDFHEKMVLAVLKGLNVEETDALTKALTKLQAFFRSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C2D3</accession>
    <name>A0A174C2D3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06459">
        <property type="protein sequence ID" value="CUO06459"/>
        <property type="gene ID" value="ERS852478_01752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO06459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="39" mass="4654" checksum="FD5388C6A72DF390" modified="2016-09-07" version="1">MKKEAIEKATSDFDPLFSNEYDIDWEDDEDLLKKLYGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CD09</accession>
    <name>A0A174CD09_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11312">
        <property type="protein sequence ID" value="CUO11312"/>
        <property type="gene ID" value="ERS852478_01883"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO11312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="67" mass="7525" checksum="A85375AD7B85F53C" modified="2016-09-07" version="1">MITRGISRDIVSRDCLVDIIITMNKNCKGGTDMAQQKEGGSIYSQKYRKVIGYKKHVGGCRIAEYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CIE5</accession>
    <name>A0A174CIE5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-binding transcriptional activator DcuR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200425.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPC010000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11525">
        <property type="protein sequence ID" value="CUO11525"/>
        <property type="gene ID" value="ERS852478_01891"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO11525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="65" mass="7744" checksum="7940C2720E6860AE" modified="2016-09-07" version="1">MQEQTLELIRSYLEENKWIFLSSNEIASKVNLSRITVRRYMNYLVENREIISQIDYSTGEETALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CIJ7</accession>
    <name>A0A174CIJ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative ABC transporter ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Putative multidrug export ATP-binding/permease protein SAV1866</fullName>
            <ecNumber evidence="10">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BWLFYP14_02195</name>
        <name evidence="10" type="ORF">ERS852478_01938</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200457.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13053">
        <property type="protein sequence ID" value="CUO13053"/>
        <property type="gene ID" value="ERS852478_01938"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="172"/>
            <end position="192"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="298"/>
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    </feature>
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        <location>
            <begin position="33"/>
            <end position="317"/>
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            <end position="581"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO13053.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VUX65830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="588" mass="66170" checksum="B7BFFD10030D918F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CNB3</accession>
    <name>A0A174CNB3_9FIRM</name>
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        </submittedName>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in cyanobacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01945</name>
        <name evidence="3" type="ORF">GT712_02615</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
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    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uma2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO13258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS88006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="185" mass="21476" checksum="C9DA5045604BF0D9" modified="2016-09-07" version="1">MPLLEEEYRKEEKINGVIYDMSPSPNYQHGIVDGNIYSIIKSGLKGTLCLAFMENLDYKYHAQENNDYVIPDVMIICDRKHLKGGSYTGTPRFIVETLSPATALRDKTVKKELYQNAGVEEYWIISPRERAVEIYYLENGKYDLKYSYILQDDSEEEHYNADTVVTLKDFPKISMTLAEMFENVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CWX0</accession>
    <name>A0A174CWX0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore cortex-lytic enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
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            <taxon>Clostridia</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200521.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17517">
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        <property type="gene ID" value="ERS852478_02056"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF47090"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="347"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO17517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="422" mass="47965" checksum="E08A34EAC02EBDA6" modified="2016-09-07" version="1">MAFYHMQMQQENIDTGQYQVTVSDRLNNRPIENARVRISYTGAPDSTIEEVATDSSGRTPVIELKAPPLEYSMEPVEQQPYSEYTIQIEAEGFEPKEIAGSQVLADTLSRQPTTLNVMESGETFQRIVIPPHTLFYEYPPKIEEAEIKPINENGEIVLSKVVVPEYIVVHDGPVNDSAAGNYYVRYKDYIKNVASSEIYATWPDDTIRANVLAIMSFTLNRVYTEWYRNKGYNFTITSSTAYDHKWIYGRNIFASIDRIVDELFENYLSRPNVRQPILTQYCDGKQVQCRNRGWMTQWGSKALGDQGYSAIEILRTFYGNDMYINVAEAISGIPASWPGYDLDIGASGNKVRQIQEQLNTIAEAYPAVPVVTADGIYGPETQNSVRIFQSIFGLDQTGIVDYPTWYKIQEIYVAVSRIAELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D4V8</accession>
    <name>A0A174D4V8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacterial protein of uncharacterized function (DUF961)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200570.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20752">
        <property type="protein sequence ID" value="CUO20752"/>
        <property type="gene ID" value="ERS852478_02139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010365">
        <property type="entry name" value="DUF961"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038620">
        <property type="entry name" value="YdcP-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06125">
        <property type="entry name" value="DUF961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO20752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="107" mass="12177" checksum="3A6A5E04024C9A2E" modified="2016-09-07" version="1">MELRFVVPNMEKTFGNLEFAGENTTEQQRINGRMAVINRSYNLYSDVQRADDVVVVLPAKAGEKHFSPEQKVKLINPRITTDGYKIGERGFVNYILLADDMLPVESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D707</accession>
    <name>A0A174D707_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005334925.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21502">
        <property type="protein sequence ID" value="CUO21502"/>
        <property type="gene ID" value="ERS852478_02163"/>
    </dbReference>
    <dbReference type="GeneID" id="42423213"/>
    <dbReference type="GeneID" id="64017248"/>
    <dbReference type="GeneID" id="66495323"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="80"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO21502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="139" mass="16514" checksum="A52608E3384972E5" modified="2016-09-07" version="1">MKPSDFQKTVMCRFDSCLKKTVFGVVKDYYKELKKNQAEAIPFCELPDIIIDKVAIWDTYKTDYTTFNICGHDIYVYDDELAKVIKQLSDRYRENVLMYYFLDMSDTEIAKLQNISRSGVFQNRHYALKQMKKSLEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7J2</accession>
    <name>A0A174D7J2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NAD(P)H-dependent FMN-containing oxidoreductase ywqN</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ywqN</name>
        <name evidence="2" type="ORF">ERS852478_02116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060821.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20025">
        <property type="protein sequence ID" value="CUO20025"/>
        <property type="gene ID" value="ERS852478_02116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO20025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="174" mass="19317" checksum="7468B498696835C7" modified="2016-09-07" version="1">MKIVIINGSARKGNTLAAINAFIKGASEKNEIEIIEPDNLNIAPCKGCGVCQCSKGCVDKDDTNSTIDKIAAADMILFATPVYWWGMSAQLKLIIDKCYCRGLQLKNKKVGTIVVGGSPVGSIQYELIDKQFDCMAKYLSWDMLFKKSYYATARDELEKNKDSMNELEWIGKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D9L8</accession>
    <name>A0A174D9L8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoid occlusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">noc</name>
        <name evidence="3" type="ORF">ERS852478_02137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20688">
        <property type="protein sequence ID" value="CUO20688"/>
        <property type="gene ID" value="ERS852478_02137"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="16"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO20688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="289" mass="33932" checksum="FD2C7A8B678616C4" modified="2016-09-07" version="1">MTEPNRQSEENEERIIEIEIERLRPFKEHPFQVKDDKEMFLLQESIEKYGILNPLIVRPVPDGYYEIISGHRRKHAAEKLGYRKVPVIIRVLSEDDSILSMVDSNLHRERISYSEKAFAYKLKNDVLKRKSGRKKSQVDHKTPRKRAIEIISEDCGDSPKQVQRYISLTKLIPEMLQKLDDEIISFCPAVEIAALSEKEQRELLVAMEYAQAIPSLSQAQRIRQLSKEKQLSLEKMEEIMCEVKKGEITRVAFTNEQLHKYFPNSYTPAMMKREILALLKLWKKESWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DWI6</accession>
    <name>A0A174DWI6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bacterial capsule synthesis protein PGA_cap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_02356</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200705.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28578">
        <property type="protein sequence ID" value="CUO28578"/>
        <property type="gene ID" value="ERS852478_02356"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PGA_cap" evidence="5">
        <location>
            <begin position="106"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO28578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="464" mass="50518" checksum="6404D107493C5343" modified="2016-09-07" version="1">MSLQSNKRSQTKSSSARRKDIYKKSKYYQEKRQKLLIATGIGIFVLVFILILAGIRGCSNYMSSRQAAAKKTVSMNASKDNSQKASSDSQNTDSSNATVSSPVSLTLSVVGDCTLGTDETFDYDTSLNAYYENYGADYFLQNVKDIFSTDDLTIANFEGTLTDSDEREDKTFAFKAPASYASILTGGSVEAVNTANNHSHDYGNQSFDDTLAALDDAGIVHFGYDETAVMDVKGIKVGLVGIYELYDHLEREQQLKDNIAKVKADGAQLIVVIFHWGNETETVPDSNQTTLGRIAIDEGADLVCGHHPHVLQGIETYKGRNIVYSLGNFCFGGNSSPSDMDTMIYQQTFTIDADGVKKDNVTNIIPCSISSAAYDGYNNYQPTPAEGDEATRILGKINERSSWISTAEGSTFTAKYNSNNDSQSSSADTAASDSDIVDMNSSDSDDTDAETYDESYDTDNSDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E641</accession>
    <name>A0A174E641_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized ABC transporter ATP-binding protein YbhF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybhF_3</name>
        <name evidence="5" type="ORF">ERS852478_02498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380893.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33233">
        <property type="protein sequence ID" value="CUO33233"/>
        <property type="gene ID" value="ERS852478_02498"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO33233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="300" mass="34377" checksum="2C823061BE56A4CE" modified="2016-09-07" version="1">MIEIRNCSKAFGEIHAIDHVLMEIGERQIFGLVGTNGAGKSTLLRMAAGVIKPDEGEILVDQEPVYENEKIKQQIFYISDGGYFPQGYTAADLKDFYREYYPDFMTDRYSKLMDQFHLDEKRRISSYSKGMKKQLLVIMGISAGTKYLLCDETFDGLDPVMRQAVKSLFVSEIMNRDFTPVIASHNMRELEDVCDHVGLLHKGGILLSRELEDMKFHIHKIQCVLPDQTKEEALLKELDVLKKEHQGSILILTARGSREEILQKVQTQNPIFCEVIPLTLEEIFISETEVAGYEVKNIFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ELH2</accession>
    <name>A0A174ELH2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-dependent Clp protease proteolytic subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Clp protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02610</name>
        <name evidence="3" type="ORF">GT712_07420</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000011">
        <property type="protein sequence ID" value="MZS88900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36870">
        <property type="protein sequence ID" value="CUO36870"/>
        <property type="gene ID" value="ERS852478_02610"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO36870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS88900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="250" mass="27446" checksum="0D0E4A843C5275D5" modified="2016-09-07" version="1">MSENRYGEKREESETGMKLQNCETQESENKVQESTNEQIKDMGQVVLNSNSRKHKVELLTIIGEVEGHESAPSHSKTTKYEHVLPKLAIIEDDEEIEGLLILLNTVGGDVEAGLAIAEMIASLSIPTVSLVLGGGHSIGVPMAVSADYSFAVPSATMVIHPVRSNGMFIGVAQTYRNMEKIQDRITTFISEHSRASQKRLEELMLDTSQLVKDVGTMLEGKEAVKEGLIDEVGGIKEALAKLYEMIEKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ETU0</accession>
    <name>A0A174ETU0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NAD(P)H nitroreductase yodC</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yodC</name>
        <name evidence="2" type="ORF">ERS852478_02690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO39929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39929">
        <property type="protein sequence ID" value="CUO39929"/>
        <property type="gene ID" value="ERS852478_02690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO39929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="179" mass="20249" checksum="E6A4D88433EE1D2F" modified="2016-09-07" version="1">MMEFQKLIEVRRSIRKYATDKKVTKEELMEMIGAAQEAPSWKNTETGRYYCVLSEEMTERVRRECLPEGNARKAENAVLVVTTFVKDKAGFQNDKTADNELGNGWGCYDLGLKNENFVLKAAELGYGTLIMGLRDGEQLRKVLDIPEEETVVAVIAVGVAAEEPKRPRRKGLDEIVKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EXS3</accession>
    <name>A0A174EXS3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="8">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfp_2</name>
        <name evidence="8" type="synonym">pfp</name>
        <name evidence="10" type="ORF">ERS852478_02745</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200883.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41458">
        <property type="protein sequence ID" value="CUO41458"/>
        <property type="gene ID" value="ERS852478_02745"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01978">
        <property type="entry name" value="Phosphofructokinase_II_B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011404">
        <property type="entry name" value="PPi-PFK_XF0274"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036483">
        <property type="entry name" value="PFK_XF0274"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="9">
        <location>
            <begin position="7"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="188"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="8">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="8">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO41458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="410" mass="44941" checksum="F13ADC3821A9B6F2" modified="2016-09-07" version="1">MSRKNLIVGQSGGPTAVINSSLYGVVSEGMRHPEAIEHIYGMINGIEGFLNGTVLDFAEALPGEKLDGLKVTPGAYLGSCRYKLPESLEDPVYPRLFKKFEEMNIGWFFYIGGNDSMDTVSKLSRYAAQTGSDIRILGEPKTIDNDLIHTDHTPGFGSAARYVASTVREITIDANVYEKKSVTIIEIMGRHAGWLTAASALARKYTGDNPLLIYLPETAFNQEEFLKAVENSFEKNCNVIVCVSEGIHDDKGTFICEYDNSVGTDTFGHKMLAGCGKYLENLVRNRLGVKARSVELNVSQRCSASMMSATDQQEAIKAGEFGVKAALNGETGKMISFIRKETSDGTYTMECGLEDVNAICNEEKTVPSEWITEDGSDVTEAFINYARPLIQGTVQIPCGEDGLPSFVYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZB7</accession>
    <name>A0A174EZB7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cph2_4</name>
        <name evidence="8" type="synonym">cph2_1</name>
        <name evidence="8" type="ORF">BWLFYP14_01072</name>
        <name evidence="7" type="ORF">ERS852478_02780</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42811">
        <property type="protein sequence ID" value="CUO42811"/>
        <property type="gene ID" value="ERS852478_02780"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="32"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="6">
        <location>
            <begin position="189"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="5">
        <location>
            <begin position="324"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO42811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX63714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="575" mass="65809" checksum="4CB1BAB1ECE9A73A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FBM8</accession>
    <name>A0A174FBM8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular solute-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Glycerol-3-phosphate transporter periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02879</name>
        <name evidence="4" type="ORF">GT728_17195</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000057">
        <property type="protein sequence ID" value="MZL34877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705934.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45730">
        <property type="protein sequence ID" value="CUO45730"/>
        <property type="gene ID" value="ERS852478_02879"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252773" evidence="2">
        <location>
            <begin position="27"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO45730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="456" mass="50805" checksum="0C3615E52B2EAF9B" modified="2016-09-07" version="1">MKRRGMALGLAALMTCTALFTTTAKAENKGSDEKETIKFTYWGSGDEKKAIEESVDKFMEANPNIEVDLMHIPSEDFLTKLNAMIAAGEAPDVSYSASWKCQMGEDGLIYNFYDLLDDMGLSKDDYLSTCWWNWSPTESAGPVQANVTTNLMYNVDCFEEAGVDLPPTKVEEAWSWDEFVEMAQKLTLDTEGRNAADPDFDANNIKQYGVMFGTDWNVYMPFILSAGGGYLNESMDGLGLNDEKSAQILQNFADLINVYHVSPTAVQKNAMPSAATALAAKQTAMYIDGSWNHLDLMNSGCNWGVGVLPIDENYTTFFDGGSLIIFKSTKHLEASEKLYLWLTNPESSERITELYRTLWMPVQTEYYTDPDKIDFWASEELPARPEGFQDAIVKATYDHAVVATEINVKNFNEINTLVGSALEQVWSGKKTAEEAMTEVKSQTDSLVEGTYSGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FJA0</accession>
    <name>A0A174FJA0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF2971)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201076.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50354">
        <property type="protein sequence ID" value="CUO50354"/>
        <property type="gene ID" value="ERS852478_03018"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033EBY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021352">
        <property type="entry name" value="DUF2971"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11185">
        <property type="entry name" value="DUF2971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO50354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="311" mass="36908" checksum="C48EF425D0658D39" modified="2016-09-07" version="1">MIVYHYCSLESLNSILKNRSLRLTNILKSNDSMEISWICRYYDAEFKRAYENASDLFRSKISSERLMGYVKLFTDEFFNENHADFRYYVTCFSYQNDLLSQWRGYADDGRGAAIGFDLDVLKEVVMVSPEISKPSIVSLHKISYSETEQREVVHQIVHELVDEIEKILQKEEQCRESIEEKQDYEIEVLDKVMNCFEKKFLKLFQESVYMKNPFFREESEIRLCEFSPKQFLMGREVELSLGARLYNYSYYVKESQLISYVDFDFSDCLDQLIKELVIGPKCLMSERDMEYYLTTLGLSNCRVKKSHGTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FLU8</accession>
    <name>A0A174FLU8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">phoU</name>
        <name evidence="3" type="ORF">ERS852478_02998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO49796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201066.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49796">
        <property type="protein sequence ID" value="CUO49796"/>
        <property type="gene ID" value="ERS852478_02998"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="119"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO49796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="223" mass="25345" checksum="E3E9F3AB3461BED1" modified="2016-09-07" version="1">MSKYFERQLEELHIQLITLGSYCEKAISFSAKAIQKVQNEEIAGQVFETDRDIDAKEREIENLCLSLLLHQHPVARDLREISAALKMVSDMERIGDQAADIADLSLYVAKNTTAIPETITQMAEDTVRMVTESVDAFVKSDLELCRNVIDRDDVVDDAFNEIKEKLADMIYGGNLDAKTGLDLLMTAKYFERIGDHAVNIAEWVEYSITGQHRNNEHQDYLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FRE8</accession>
    <name>A0A174FRE8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor WhiG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO52783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201126.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52783">
        <property type="protein sequence ID" value="CUO52783"/>
        <property type="gene ID" value="ERS852478_03084"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="81"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO52783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="146" mass="17683" checksum="EFDFF2EB25868994" modified="2016-09-07" version="1">MTPNRREFEKQCTFQKFCKSVLHNEACNAHEEIRRRRVREVTFSDLALYEERQLYTVDKYFQDEEAEPSYQMAGKEITPKLLLEAIRALPEERRKIVLLYYFEGLTDIEIGKQLNISRSTVQYRRTSSFEQLKKYLEENADEWIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FRQ3</accession>
    <name>A0A174FRQ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-type ATPase subunit delta</fullName>
            <shortName evidence="6">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpH_2</name>
        <name evidence="6" type="synonym">atpH</name>
        <name evidence="7" type="ORF">ERS852478_03035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="6">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201086.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50795">
        <property type="protein sequence ID" value="CUO50795"/>
        <property type="gene ID" value="ERS852478_03035"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0139">CF(1)</keyword>
    <keyword evidence="2 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO50795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="179" mass="19986" checksum="AE93D8BB4D05A76A" modified="2016-09-07" version="1">MTKTARVYGGSLYDLAAEEKLDGQIMEQMIAVRQIFRENPGYLKLLGEPAIPEDERLKMIEEAFGGQAERYLVNFLKLLCERKILREFAGCCEEFIRRYNSAHGIAEAVVTSAVKLSDTQMEALKAKLEKLSGKKVYLVQKTDASVLGGLRVELESVQLDGTVQSRISGISKKLNELVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FUI0</accession>
    <name>A0A174FUI0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial Ig-like domain (Group 2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO52269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201102.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52269">
        <property type="protein sequence ID" value="CUO52269"/>
        <property type="gene ID" value="ERS852478_03074"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021984" evidence="1">
        <location>
            <begin position="25"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="2">
        <location>
            <begin position="512"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO52269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="783" mass="85632" checksum="C2812C519EC493AA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FZ65</accession>
    <name>A0A174FZ65_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminobenzoyl-glutamate utilization protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">abgB</name>
        <name evidence="2" type="ORF">ERS852478_03175</name>
        <name evidence="3" type="ORF">ERS852523_03506</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000053">
        <property type="protein sequence ID" value="CUP98394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000094_gene755"/>
    <dbReference type="EnsemblBacteria" id="CUO55504">
        <property type="protein sequence ID" value="CUO55504"/>
        <property type="gene ID" value="ERS852478_03175"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP98394">
        <property type="protein sequence ID" value="CUP98394"/>
        <property type="gene ID" value="ERS852523_03506"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017145">
        <property type="entry name" value="Aminobenzoyl-glu_utiliz_pB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037227">
        <property type="entry name" value="Aminobenzoyl-glu_utiliz_pB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO55504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP98394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="505" mass="56489" checksum="D18990D6DC1720E9" modified="2016-09-07" version="1">MGQEEKYMDEYIKEISEKIEDKKEYYAKISDKIWEYAEPRFQEYKSSELLQQTLKKEGFSIKSNLAGEETAFIAEYGSGKPVIGFLGEFDALPGLSQKADTTERIPEEKTSDSKYESVPEREKKQNPDSGHTDNCGHGCGHQLIGTGTLASVIALKDFMKEHNLKGTIRYYGCPAEENAGGKAFLVRDGYFDDCDLALCWHPEQGRRACYGSTKANFRVFFTFHGTPAHASMCPELGRSALDAVELMDVGVNYMREHMIDEARIHYAITDTGGDAPNVVQSRAQVLYAIRAPKITQVKELYNRVCNIAKGAALMTETTVEIRQVAAYSNLISSKILADHMNTYLEKLGPIPYTEQEYAYAQKFQQSLSDQDKNQLPTIARDYFGPKAPEAMKTPIFEPIACQNLYSDLKYSTDVGDVSWIVPTVHLNIPTFAAGTALHSWQAVAQGKSSIAHKGMLYAAKIMALTALDFLQNPELANQARKELTETLNGETYPNPLPKDLKPEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G173</accession>
    <name>A0A174G173_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Melibiose operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">melR_4</name>
        <name evidence="5" type="ORF">ERS852478_03180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380869.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55681">
        <property type="protein sequence ID" value="CUO55681"/>
        <property type="gene ID" value="ERS852478_03180"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="198"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO55681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="301" mass="34650" checksum="B7869D64B34FD59E" modified="2016-09-07" version="1">MAMRKILVDETNRELCEHGTVGFPMTVNHDDLWAFEGKSVPIHWHNDLEISLPREGEAIYQVYQKSYTVRPGDVLLLNRNVPHSCHSSNNSHARYSTFLARPDFIYGEYGSDVERRCFRPFLQNSSVPCILLASGNSCTRTVIQKLNETEALFDQKTFCYELKIKGLLCEIFGMILCEHQNDLAKFVPANQLELERLEQMLDYLNTHFESVISLQELADQVHLSKEVCCRLFKKMTGKTITGYLEEYRVNQSLPLVQSSQYSMIQIADMTGFSNASRFARAFRRQFGCNPGEYNSLKLQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GD86</accession>
    <name>A0A174GD86_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavoredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">flr_2</name>
        <name evidence="3" type="ORF">ERS852478_03300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO59901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59901">
        <property type="protein sequence ID" value="CUO59901"/>
        <property type="gene ID" value="ERS852478_03300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Flavin_Reduct" evidence="2">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO59901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="157" mass="17039" checksum="E283B539F3E07113" modified="2016-09-07" version="1">MPVLMVATYNEDGSINVMNAAWGTMQERDTVALNLTETHKTVQNIKARGAFTVSIADAAHVTEADYFGVESGNREPDKFARSRLTATKSETVDAPIINNFPPRTKRQSDKLSLTALNITCLILYGILPIHVVTAWADSSGNVLPDIGSAPLQLMILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GDH2</accession>
    <name>A0A174GDH2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SseB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO58960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060037.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58960">
        <property type="protein sequence ID" value="CUO58960"/>
        <property type="gene ID" value="ERS852478_03275"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5031T37">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="19"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="142" mass="15889" checksum="11AC0CCAAE32A17F" modified="2016-09-07" version="1">MSDNKNVNQDKGLQGNEKIEQAIAALQQEATQEMLAHTLTVIRRRMREKGQFILSVEPPTGDNQLRIGTVKTGDGKIWWAAFTGFEEELKGGGSVQSTFLTDIDQLFHSALQVNEIEGIILNPWNRTIMLDKNLINIILGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GHF5</accession>
    <name>A0A174GHF5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RelA_SpoT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO62004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201329.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62004">
        <property type="protein sequence ID" value="CUO62004"/>
        <property type="gene ID" value="ERS852478_03365"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="2">
        <location>
            <begin position="122"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO62004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="268" mass="31812" checksum="E201E0EB82BBCF93" modified="2016-09-07" version="1">MIEAGGSDSAYALIERKVNIIINNFNKILRSLTHESGDNTSLFCIDSIELKCVLSAENSEKIYLNKEIEESWTEEDIELFHKLSFEERVFYADYLSTEFEITKFLMDFAKINKAVLAGLEYRVKSPKSLYNKLYQRVEKSFFDSIADVIRYTVILEPKNYVEQIRSVTDALYEKNWKIYSLKNYWVNDSFPYNGVNAKFKNSRNYRIEIQFHTQESFDVKMSEEDHKLYEQRRVLEPGCEEYNRILQLQLKLYSDMEYPENIADLEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GMJ2</accession>
    <name>A0A174GMJ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201372.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63181">
        <property type="protein sequence ID" value="CUO63181"/>
        <property type="gene ID" value="ERS852478_03398"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025427">
        <property type="entry name" value="DUF4160"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13711">
        <property type="entry name" value="DUF4160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO63181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="92" mass="10592" checksum="916D829665A232B1" modified="2016-09-07" version="1">MPQILRIGPYSIYFWSNEGDPLEPIHVHVSEGRASATATKIWITSTGKTILSNNNSKIPEKILKRLMRMIEANSSDIIDEWLNHFGEIRYFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GRG5</accession>
    <name>A0A174GRG5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2 4">group II intron-encoded protein LtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ltrA_3</name>
        <name evidence="4" type="synonym">ltrA_8</name>
        <name evidence="4" type="ORF">BWLFYP14_02784</name>
        <name evidence="2" type="ORF">ERS852478_03418</name>
        <name evidence="3" type="ORF">GT712_13165</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO63867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000026">
        <property type="protein sequence ID" value="MZS89996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000057">
        <property type="protein sequence ID" value="VUX66410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380660.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63867">
        <property type="protein sequence ID" value="CUO63867"/>
        <property type="gene ID" value="ERS852478_03418"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO63867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS89996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="261" mass="30368" checksum="AB62AAA2AA7107C4" modified="2016-09-07" version="1">METKLARISQLSKENPDMVFTSLGHLINKEMLENCHVQMDGTKAVGIDGVTKEEYGRNLEENLEALIESLKKKSYKPKPARLVEIPKDNGKMRPLSIYCYEDKLVQEALRRILEAVFEPMFYDEMMGFRPNRGCHKAIRKLNIMLERKPTNYVLDADIKGFFQHLDHEWIVRFIESRIKDPNIIRLVRRMLKAGIMNNYEFEATEEGSGQGSVCSPIISCIYMHYVLIWWFREVVTPMLKGYAGLVVYADDCAPRRRKLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GSW4</accession>
    <name>A0A174GSW4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02257</name>
        <name evidence="2" type="ORF">ERS852478_03423</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO63949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058916.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63949">
        <property type="protein sequence ID" value="CUO63949"/>
        <property type="gene ID" value="ERS852478_03423"/>
    </dbReference>
    <dbReference type="GeneID" id="66495131"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033253395" evidence="1">
        <location>
            <begin position="29"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO63949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="159" mass="18037" checksum="2117DFFEE1412285" modified="2016-09-07" version="1">MKRKRFSRLLFLMLTIMITVTFYQPAQAASGKYTGTYTKTWSVSSNMTVTIKPSYSVIVNKVTSTKVRLQLEKLGVNGSPIYATAPITAKRKGNTVSFKWKDTWGNSGTGTLKLYKGYVKLKVKQTYTARWNRSTLDTSGKYMKIYRQSGNTKMDNIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GU30</accession>
    <name>A0A174GU30_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_02272</name>
        <name evidence="1" type="ORF">ERS852478_03438</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64329">
        <property type="protein sequence ID" value="CUO64329"/>
        <property type="gene ID" value="ERS852478_03438"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO64329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX65907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="368" mass="44181" checksum="FA019C77BA338A0B" modified="2016-09-07" version="1">MEKTIKKDIWEMISSVSYSTHIAGNAGRADQKFFEHLQEGIADNDLDKIYEFIDAYERGKSIKPDELVCRLFQKAYREDSARLCQLLAEKNNIVDYWIFLSTCCETDMLVDFAKMDVAYPCFYYECARILLKRTSGIDEKCKEAIIAAVKRIADRDLALWERWVQRKEHNTNWQQLLFSVLSKVSREALKRFAQTINLDMMLQNHKEDIVAWEFERLSDTSKKYILENISKDILENWNLLFEKKKKKHENLREIWFSGYFSLILNSLQYDLKNKEEWKLSFLNYEKILEKDMYAWYEKTTHMCCAFFYDITQIFYIVLAGQEKQIIEADESVTQSIRKIQLFIRRHEDYWKDHVKQKIELEHRLEAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GXX0</accession>
    <name>A0A174GXX0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxiredoxin bcp</fullName>
            <ecNumber evidence="2 3">1.11.1.15</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative peroxiredoxin bcp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bcp_2</name>
        <name evidence="3" type="synonym">bcp_1</name>
        <name evidence="3" type="ORF">BWLFYP14_02350</name>
        <name evidence="2" type="ORF">ERS852478_03480</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.11.1.15" evidence="2 3"/>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65639">
        <property type="protein sequence ID" value="CUO65639"/>
        <property type="gene ID" value="ERS852478_03480"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO65639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="121" mass="13748" checksum="21031FA1DEE23A40" modified="2016-09-07" version="1">MILYFYPKDNTPGCTKQACGFSERYPQFTEKGAVILGVSKDSVASHKRFEEKYGLAFTLLADPERKVIEAYDVWKEKKNYGKVSMGVVRTTYLIDEQGIIIKANDKVKAADDPENMLKELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H2T0</accession>
    <name>A0A174H2T0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">luxO</name>
        <name evidence="7" type="ORF">ERS852478_03599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201459.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69332">
        <property type="protein sequence ID" value="CUO69332"/>
        <property type="gene ID" value="ERS852478_03599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="130"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO69332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="256" mass="29572" checksum="D1103A86516AF922" modified="2016-09-07" version="1">MKKILLIDDSDTYTWCLQKYLQHRGYPVKTACTLKEARTAIQEEMPLVVCCDLDLPDGSGMDFLDEVRAADKELPFILASCHDKDDYEQEAMRRGATLCMDKMKGLLLQDKLVEYAYRQLSGEKAPTFHKLLFVYAEDTSAEVLRAAMLQKGFDLILVSSIWEAKRRIFEDKEIELILCDLELPDGTAMELFHTLRRVAGMFQMKNPPVRLLPFFILTENNDPATEYEYRHEGVNDYITAPVNIPELIRQVLFFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H412</accession>
    <name>A0A174H412_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type transport system involved in multi-copper enzyme maturation, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_03541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201423.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67535">
        <property type="protein sequence ID" value="CUO67535"/>
        <property type="gene ID" value="ERS852478_03541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO67535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="356" mass="41327" checksum="3A5806E894254D46" modified="2016-09-07" version="1">MKTIIKRSILDYLKNPVLWIGLIIIVASMYQCLSSYLQIHYIKQNEQITQNDVALEDADVMDGYIPTSDDKERRREWEDTIKETLMDTSKNGFGFSRQEADHVMKEIQNMDVKTASEFLESQYGYYNAIYAYEDLEIHKGTAEEINHYIERKLSEHSFSWYFAKKFTDFAGLHMAFFATVLLSFLFIQDTRKSTYELLHTKPVTAVQYICGKVISGFISMLGVLVILNVIFFMLCLKTSLESGFPVTPIDFCVNSLIYIIPNILMICCVYTITAVIFKNPLPAAPILFLHIIYSNMLTMKNDIYYMRPFSIMVRFPGRFFETHVAKMSNINQIILVISSVILVCISVIIWKRRRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H7C6</accession>
    <name>A0A174H7C6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201456.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69246">
        <property type="protein sequence ID" value="CUO69246"/>
        <property type="gene ID" value="ERS852478_03595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="138" mass="15754" checksum="6EA4527E885985C8" modified="2016-09-07" version="1">MKKINFCKATTIILIINVILSIVLFFVVPDKIAIQWVGTSPSNAVDSYYVFLVPVLSVLFAFTGKPIFTMFLFRLWNRSNEHLVTYLNLCLQVVFLTCEIYIGLYNLCNFNVAISIILIVELMIDVVIGLKLFHNQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H8W4</accession>
    <name>A0A174H8W4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71353">
        <property type="protein sequence ID" value="CUO71353"/>
        <property type="gene ID" value="ERS852478_03665"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZTUJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO71353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="49" mass="5853" checksum="C3C9AAA3F868435B" modified="2016-09-07" version="1">MAKRKRNIQILFCVSPEEKKLIRRKMIESKTKNMGAYGVLFIFCFRESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H9E9</accession>
    <name>A0A174H9E9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Conjugal transfer relaxase TraA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_03620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MobA/MobL family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO69966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015530716.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69966">
        <property type="protein sequence ID" value="CUO69966"/>
        <property type="gene ID" value="ERS852478_03620"/>
    </dbReference>
    <dbReference type="GeneID" id="15232335"/>
    <dbReference type="eggNOG" id="COG2433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005053">
        <property type="entry name" value="MobA_MobL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03389">
        <property type="entry name" value="MobA_MobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0184">Conjugation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobA_MobL" evidence="5">
        <location>
            <begin position="17"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="371"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="526"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO69966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="573" mass="67055" checksum="EEA948AE4AF06491" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HKP6</accession>
    <name>A0A174HKP6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase domain (DUF772)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_03805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000052">
        <property type="protein sequence ID" value="CUO75503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75503">
        <property type="protein sequence ID" value="CUO75503"/>
        <property type="gene ID" value="ERS852478_03805"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF772" evidence="6">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="5">
        <location>
            <begin position="91"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO75503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="291" mass="33105" checksum="3695D03908D096DD" modified="2016-09-07" version="1">MDVMQKTPILLFKYLLLKYLYNLSDNGVVERSRYDMSFKYFLELTPEEEVIHPSLLTKFRKQRLKDENILDLLINKSVELAINQGVLKSNTIIVDSTHTEARYHKTTQREMLKKASTSLKAALKAALKDSDKDIYLPDEPEKRASLDEYNEYCHELLNTVQESPYSELPTIKEESSMLSEILDNQIDCYDQSIDPDARIGHKTVNSSFYGYKTHLAMTDERIITAATITSGEAFDGQELPVLVQKSKAAGATVNEVIADTAYSTLENLKDAQSNDYKLTYCATSNRLCENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K9F1</accession>
    <name>A0A174K9F1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_03105</name>
        <name evidence="1" type="ORF">ERS852478_01129</name>
        <name evidence="2" type="ORF">ERS852523_00450</name>
        <name evidence="3" type="ORF">GT728_00810</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
            <strain evidence="2 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP07026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2172"/>
    <dbReference type="EnsemblBacteria" id="CUN81171">
        <property type="protein sequence ID" value="CUN81171"/>
        <property type="gene ID" value="ERS852478_01129"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07026">
        <property type="protein sequence ID" value="CUP07026"/>
        <property type="gene ID" value="ERS852523_00450"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50348FZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN81171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP07026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL31773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="51" mass="5929" checksum="6E2362D76F0290A7" modified="2016-09-07" version="1">MSELKLVTRNIRINGIQHKASDMSEEEIKCLLIQRQDIILLNMNYERKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KK88</accession>
    <name>A0A174KK88_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00714</name>
        <name evidence="3" type="ORF">ERS852523_00630</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP12534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055149533.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000016_gene3659"/>
    <dbReference type="EnsemblBacteria" id="CUN65447">
        <property type="protein sequence ID" value="CUN65447"/>
        <property type="gene ID" value="ERS852478_00714"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12534">
        <property type="protein sequence ID" value="CUP12534"/>
        <property type="gene ID" value="ERS852523_00630"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZA4G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN65447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP12534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="198" mass="22542" checksum="98231258237305F2" modified="2016-09-07" version="1">MNHIKNIWKCFEEKHATFAKWLYQIFYFVIFSMGVTVFQYLVFTFLPGILGIGLAGTEFMWPKVSMNLFGVKFTWSLLGYNVLRDATGNILIGGGLGYFISYELGSFLAQCINFPLQRNITFKSHGNPVYQAIWYFVAWVVISLICNGFNNLWMPVASAYVAPAVYNMLVTIITGGVSMVIFFFVFKIIFPEGKAESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KQ21</accession>
    <name>A0A174KQ21_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6 8">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 14" type="primary">glmM</name>
        <name evidence="13" type="ORF">ERS852478_00763</name>
        <name evidence="14" type="ORF">ERS852523_00579</name>
        <name evidence="16" type="ORF">GT712_02940</name>
        <name evidence="15" type="ORF">GT728_03985</name>
    </gene>
    <organism evidence="14 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">2789STDY5834863</strain>
            <strain evidence="14 18">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="15 19 20" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 20">BIOML-A1</strain>
            <strain evidence="16 19">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="6 8"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP11269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706453.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000036_gene2412"/>
    <dbReference type="EnsemblBacteria" id="CUN67334">
        <property type="protein sequence ID" value="CUN67334"/>
        <property type="gene ID" value="ERS852478_00763"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11269">
        <property type="protein sequence ID" value="CUP11269"/>
        <property type="gene ID" value="ERS852523_00579"/>
    </dbReference>
    <dbReference type="GeneID" id="66493538"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="3"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="171"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="256"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="374"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="6">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN67334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUP11269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL32377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZS88067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="448" mass="49152" checksum="26AB60440A5D2065" modified="2016-09-07" version="1">MGKYFGTDGFRGEANVKLTVDHAFKVGRYVGWYYGRDHKAKIVIGKDTRRSSYMFEYALVAGLTASGADVYLLHVTTTPSVSYAVRTEDFDCGIMISASHNPFYDNGIKLLNGNGQKIEAEVEARIEAYLDGLIEDLPLATKEDIGRTVDFASGRNRYIGHLISIPSRDFKGIKVGLDCANGSSSAIAKSVFEALQAKTYVINNQPDGTNINTNCGSTHIEVLQKYVVDNGLDIGFAYDGDADRCIAVDHKGNVVDGDKIMYVCGKYLKEQGRLKDDTVVTTVMSNLGLYKSLEREGMKYEQTAVGDKYVAENMMENGYSLGGEQSGHIIFSRYAATGDGILTSLMVMEACVEKKATLCDLAREMKVYPQLLRNVRVADKKTARENPKVVAAVEEVAKKLGSDGRILVRESGTEPLIRVMVEAGTDELCLENVDHVVKVMESEGLLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LHB8</accession>
    <name>A0A174LHB8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">topA</name>
        <name evidence="16" type="ORF">BWLFYP14_01652</name>
        <name evidence="12" type="ORF">ERS852478_01312</name>
        <name evidence="13" type="ORF">ERS852523_00904</name>
        <name evidence="15" type="ORF">GT712_09465</name>
        <name evidence="14" type="ORF">GT728_08170</name>
    </gene>
    <organism evidence="13 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 17">2789STDY5834863</strain>
            <strain evidence="13 18">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="14 20 21" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 21">BIOML-A1</strain>
            <strain evidence="15 20">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="16 19" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000007">
        <property type="protein sequence ID" value="CUP21030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZL33175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705704.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000047_gene1261"/>
    <dbReference type="EnsemblBacteria" id="CUN88710">
        <property type="protein sequence ID" value="CUN88710"/>
        <property type="gene ID" value="ERS852478_01312"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP21030">
        <property type="protein sequence ID" value="CUP21030"/>
        <property type="gene ID" value="ERS852523_00904"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="3"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="10">
        <location>
            <begin position="163"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN88710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUP21030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZL33175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZS89291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VUX64796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="689" mass="78039" checksum="7FD4B1BFA411282B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174Q6Q3</accession>
    <name>A0A174Q6Q3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Galactose-1-phosphate uridylyltransferase</fullName>
            <shortName evidence="10">Gal-1-P uridylyltransferase</shortName>
            <ecNumber evidence="10">2.7.7.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">UDP-glucose--hexose-1-phosphate uridylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">galT</name>
        <name evidence="13" type="ORF">ERS852478_00874</name>
        <name evidence="14" type="ORF">ERS852523_02471</name>
        <name evidence="16" type="ORF">GT712_08060</name>
        <name evidence="15" type="ORF">GT728_01105</name>
    </gene>
    <organism evidence="14 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">2789STDY5834863</strain>
            <strain evidence="14 18">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="15 19 20" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 20">BIOML-A1</strain>
            <strain evidence="16 19">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000026">
        <property type="protein sequence ID" value="CUP69114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS89023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706957.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000023_gene1792"/>
    <dbReference type="EnsemblBacteria" id="CUN71824">
        <property type="protein sequence ID" value="CUN71824"/>
        <property type="gene ID" value="ERS852478_00874"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP69114">
        <property type="protein sequence ID" value="CUP69114"/>
        <property type="gene ID" value="ERS852523_02471"/>
    </dbReference>
    <dbReference type="GeneID" id="66493000"/>
    <dbReference type="eggNOG" id="COG4468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00571">
        <property type="entry name" value="GalP_UDP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000766">
        <property type="entry name" value="GalP_uridyl_Trfase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023425">
        <property type="entry name" value="GalP_uridyl_Trfase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39191">
        <property type="entry name" value="PTHR39191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006005">
        <property type="entry name" value="GalT_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01239">
        <property type="entry name" value="galT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01163">
        <property type="entry name" value="GAL_P_UDP_TRANSF_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 10 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="11">
        <location>
            <begin position="61"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="12">
        <location>
            <begin position="245"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN71824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUP69114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL31829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZS89023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="496" mass="57482" checksum="2FE2323EDD6F1146" modified="2016-09-07" version="1">MLYENIKKLVQYGVETGLTPACEKNYTINLLLDVFKEDEYVEPEEEYRDIDLEEVLNALLDEAVKRNLIEDSVVYRDLFDTRLMNCLMPRPAQVQNEFWSRYEKDPQEATDYFYKLSQDSDYIRRYRVKKDQKWTVDSEYGKIDITINLSKPEKDPKAIAAAKLVKSSSYPKCLLCPENEGYAGRVNHPARENHRIIPITVNDSPWGFQYSPYVYYNEHCIVFNSQHVPMKIEKNTFIKLFDFVKLFPHYFLGSNADLPIVGGSILSHDHFQGGHYTFAMAKAPIEKHVTIPGYEDVEAGIVKWPLSVLRIRHKDEKRLIELATHVLEAWRGYTDESAFIFAETDGEPHNTITPIARRSGDMFELDLTLRNNITTDEHPLGVYHPHAEYHHIKKENIGLIEVMGLAVLPARLKEELELLAEYILEGKDISSNEKIEKHAAWVAEFLPKYDNLDKDNIQDVLRKEVGNVFVHVLEDAGVYKCTAEGREAFMRFINKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QCW3</accession>
    <name>A0A174QCW3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_00599</name>
        <name evidence="3" type="ORF">ERS852478_02705</name>
        <name evidence="4" type="ORF">ERS852523_02553</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000027">
        <property type="protein sequence ID" value="CUP71204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000099_gene781"/>
    <dbReference type="EnsemblBacteria" id="CUO40409">
        <property type="protein sequence ID" value="CUO40409"/>
        <property type="gene ID" value="ERS852478_02705"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP71204">
        <property type="protein sequence ID" value="CUP71204"/>
        <property type="gene ID" value="ERS852523_02553"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2919">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO40409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP71204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX62821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="104" mass="11866" checksum="F5C5343CB1A47FDB" modified="2016-09-07" version="1">MGNSKKRKKKKKVGYNSLGMIAIALVVLVLLGGLMLESNDLKERLTGYDAKAATLQQQIEDEQTRTEEIDKLKKYMETDEYAEEVAREKLGLVKDNETVFKKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QZ08</accession>
    <name>A0A174QZ08_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02276</name>
        <name evidence="2" type="ORF">ERS852478_03442</name>
        <name evidence="3" type="ORF">ERS852523_02801</name>
        <name evidence="4" type="ORF">GT712_16225</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000032">
        <property type="protein sequence ID" value="CUP78442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000042">
        <property type="protein sequence ID" value="MZS90564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704376.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000068.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64421">
        <property type="protein sequence ID" value="CUO64421"/>
        <property type="gene ID" value="ERS852478_03442"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP78442">
        <property type="protein sequence ID" value="CUP78442"/>
        <property type="gene ID" value="ERS852523_02801"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO64421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP78442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="81" mass="9131" checksum="26BDCC6E1752CBC1" modified="2016-09-07" version="1">MARTRKTSKEALEEKIEKAEADVIAAKKKYDQATANLKELLDKRDAIRKEEILSAVVKSGRSYEEIMNFLNAGSDGEKTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174RNY9</accession>
    <name>A0A174RNY9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Molybdenum cofactor biosynthesis protein MoaC /MOSC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00577</name>
        <name evidence="3" type="ORF">ERS852523_03041</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000038">
        <property type="protein sequence ID" value="CUP85457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380639.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000058.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000024_gene320"/>
    <dbReference type="EnsemblBacteria" id="CUN59845">
        <property type="protein sequence ID" value="CUN59845"/>
        <property type="gene ID" value="ERS852478_00577"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP85457">
        <property type="protein sequence ID" value="CUP85457"/>
        <property type="gene ID" value="ERS852523_03041"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="39"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN59845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP85457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="144" mass="16282" checksum="D28828B3A5B28A91" modified="2016-09-07" version="1">MAKILCVCISKERKTCSQNIHECEADLQGLVGDVHYGMGGRKQVSLLPYEKVKEYFEQSEEEFRYGRFGENLLVEGIDWNSIAEGNRFRCGDVLLEAVRIGAGGPASDAYKGEKVCTPMEPWFVFCQILEAGRLREGEIILQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SGN0</accession>
    <name>A0A174SGN0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="6 14">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ptsI_2</name>
        <name evidence="21" type="synonym">ptsI_1</name>
        <name evidence="23" type="synonym">ptsP</name>
        <name evidence="21" type="ORF">ERS852478_02506</name>
        <name evidence="22" type="ORF">ERS852523_03383</name>
        <name evidence="24" type="ORF">GT712_02325</name>
        <name evidence="23" type="ORF">GT728_13260</name>
    </gene>
    <organism evidence="22 26">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 25 26" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 25">2789STDY5834863</strain>
            <strain evidence="22 26">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="23 27 28" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 28">BIOML-A1</strain>
            <strain evidence="24 27">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 14 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="6 14"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000048">
        <property type="protein sequence ID" value="CUP94868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000033">
        <property type="protein sequence ID" value="MZL34144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703702.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000026_gene985"/>
    <dbReference type="EnsemblBacteria" id="CUO33410">
        <property type="protein sequence ID" value="CUO33410"/>
        <property type="gene ID" value="ERS852478_02506"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP94868">
        <property type="protein sequence ID" value="CUP94868"/>
        <property type="gene ID" value="ERS852523_03383"/>
    </dbReference>
    <dbReference type="GeneID" id="66495257"/>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="22" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="14 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="20">
        <location>
            <begin position="6"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="18">
        <location>
            <begin position="153"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="19">
        <location>
            <begin position="250"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="16">
        <location>
            <begin position="451"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="15">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CUO33410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CUP94868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="MZL34144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="MZS87958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="538" mass="60020" checksum="67017A91D9F58CB8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174T9C3</accession>
    <name>A0A174T9C3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IS66 Orf2 like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">IS66 family insertion sequence element accessory protein TnpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tnpB</name>
        <name evidence="1" type="ORF">ERS852478_02892</name>
        <name evidence="2" type="ORF">ERS852523_03763</name>
        <name evidence="4" type="ORF">GT712_10070</name>
        <name evidence="3" type="ORF">GT728_08000</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
            <strain evidence="2 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">BIOML-A1</strain>
            <strain evidence="4 7">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000064">
        <property type="protein sequence ID" value="CUQ05101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000014">
        <property type="protein sequence ID" value="MZL33146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000017">
        <property type="protein sequence ID" value="MZS89409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46353">
        <property type="protein sequence ID" value="CUO46353"/>
        <property type="gene ID" value="ERS852478_02892"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ05101">
        <property type="protein sequence ID" value="CUQ05101"/>
        <property type="gene ID" value="ERS852523_03763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008878">
        <property type="entry name" value="Transposase_IS66_Orf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36455">
        <property type="entry name" value="PTHR36455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05717">
        <property type="entry name" value="TnpB_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO46353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUQ05101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="119" mass="13720" checksum="74EE8D5080E60E45" modified="2016-09-07" version="1">MLGDLSGVSKIFVITGRTDMRKSFDGLMAIIRDTYELDPYANAVYLFCGRDSRKLKALHFDKDGFVLLQKRLDGNGRFQWPRNASEARLLTRQEFRWLMEGLSIDQPKAIKGTGRKKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174UAX2</accession>
    <name>A0A174UAX2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00407</name>
        <name evidence="3" type="ORF">ERS852523_04334</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000103">
        <property type="protein sequence ID" value="CUQ19432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53629">
        <property type="protein sequence ID" value="CUN53629"/>
        <property type="gene ID" value="ERS852478_00407"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ19432">
        <property type="protein sequence ID" value="CUQ19432"/>
        <property type="gene ID" value="ERS852523_04334"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ19432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="83" mass="9728" checksum="765016B34A6B081C" modified="2016-09-07" version="1">MRKIWNKGHRIRASDKHLVYHFSIGTLLFVFVAVLLLLNIKQLMRTDWEHFSLLENGLTLSPYNFITILIATGVCVLVTFLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WMQ1</accession>
    <name>A0A173WMQ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BWLFYP14_02507</name>
        <name evidence="3" type="ORF">ERS852478_00006</name>
        <name evidence="4" type="ORF">ERS852523_00763</name>
        <name evidence="6" type="ORF">GT712_07870</name>
        <name evidence="5" type="ORF">GT728_12660</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN40793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP16749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000031">
        <property type="protein sequence ID" value="MZL34028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008702979.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1370"/>
    <dbReference type="EnsemblBacteria" id="CUN40793">
        <property type="protein sequence ID" value="CUN40793"/>
        <property type="gene ID" value="ERS852478_00006"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16749">
        <property type="protein sequence ID" value="CUP16749"/>
        <property type="gene ID" value="ERS852523_00763"/>
    </dbReference>
    <dbReference type="GeneID" id="66492925"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN40793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP16749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL34028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS88989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="210" mass="23333" checksum="82856842C2BD87C6" modified="2016-09-07" version="1">MSSRIEQIIGEIEEYVDSCKFQPLSTTKIVVNKEEIEELLRELRLKTPDEIKRYQKIINNKDAILEDAQTKADALIADAQARAQELVTQHEIMQKAYAQANDTINAANKQAQEILDSATQDANSIRLSAITYTDDMMANIGSVLNTTLEDAGVKYKTFIDSLQSCLDVVNHNRQELAPQTAQAAAITGSYHDNDGAKDDDDDLLDDLGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WXJ8</accession>
    <name>A0A173WXJ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_00085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43277">
        <property type="protein sequence ID" value="CUN43277"/>
        <property type="gene ID" value="ERS852478_00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="6">
        <location>
            <begin position="179"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="7">
        <location>
            <begin position="320"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN43277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="418" mass="49317" checksum="BE7DCB8D59716AD9" modified="2016-09-07" version="1">MLLSKKTSIKVSREYANLIGHMCYAASKLWNVCNYERQHYKETGMAQYPDWYYQKKAHKKDLWYKQLPSQTAQEVCRLLDKAWKSFYALKRFGGIEAPRPPRFKQESIPITYMQMGIVHERDTDRVRLSLPKTLKKYMEETYQIHENFLYLENKIFRGMDQIKQLRIYPPEKGSCKIIVVYEVPDQEELPQNGHELSVDLGLHNLMTCYDSGNGKTFILGRKYLELERYFHKEIARVQAQWYGQQSGKGVKHPVTSKHIRKLYKRKQDSVTDYLHKITRYLAEYCREQGITCVVTGDIRNIRREKDLGHRTNQKFHSLPYNRIYIMLEYKLKRYGIRFIKQEESYTSQCSPLSPEVGKRYAEPSNRKERGSYRDGNRVYNADAVGAYNILRKYHSVSGIKKELSVTGLKAPEIIKVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WYI0</accession>
    <name>A0A173WYI0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43148">
        <property type="protein sequence ID" value="CUN43148"/>
        <property type="gene ID" value="ERS852478_00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008756">
        <property type="entry name" value="Peptidase_M56"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05569">
        <property type="entry name" value="Peptidase_M56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M56" evidence="2">
        <location>
            <begin position="7"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN43148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="439" mass="50145" checksum="1B6BCACAA8B370D5" modified="2016-09-07" version="1">MELLVCMSIAGSIPVMICLFLYLIQRGNYNYILGRRLLLTGVFFYLVPVQLVKYLLPKDALPETMLIGRKADSYLSGTLSFWSEKQGDYIWIPQWFNIFARIWLAGIIIFAIYEIIKYWRGAHSIRNYIFEKIEDPEDNLTYYLIPDEICGPCTIGFFRQKIVFPESFPLHPDFIMVYKHEHTHLKNHDNLVKLLCLFVLCLHWMNPVAYLLLFLYIDTAEIVSDSVAVDGCTKEKRQDYASLLVLEAATSDIRPAVWKNNLSGHKNNKEGKDFKTLKRRINYMMKEKRKGMLQRGIMVAVSALTVMASVGTVMAYEPIQSSDVSVSDSISDYDLDFTDFGFEADNNIVDNIDTSIIDFSETNDVFISEDGTQIPIKDLSAPRAICTHSMINGYLNNHSSNGSGGCTVYVYKCQRCEKCGYLANATLYSTNTYVKCPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WZC1</accession>
    <name>A0A173WZC1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted ribosomal protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ribosomal-processing cysteine protease Prp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00098</name>
        <name evidence="2" type="ORF">ERS852523_01892</name>
        <name evidence="4" type="ORF">GT712_00975</name>
        <name evidence="3" type="ORF">GT728_02955</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
            <strain evidence="2 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">BIOML-A1</strain>
            <strain evidence="4 7">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP52194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000005">
        <property type="protein sequence ID" value="MZL32178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703122.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000020_gene128"/>
    <dbReference type="EnsemblBacteria" id="CUN43655">
        <property type="protein sequence ID" value="CUN43655"/>
        <property type="gene ID" value="ERS852478_00098"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP52194">
        <property type="protein sequence ID" value="CUP52194"/>
        <property type="gene ID" value="ERS852523_01892"/>
    </dbReference>
    <dbReference type="GeneID" id="66495927"/>
    <dbReference type="eggNOG" id="COG2868">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16332">
        <property type="entry name" value="Prp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007422">
        <property type="entry name" value="Peptidase_Prp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036764">
        <property type="entry name" value="Peptidase_Prp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39178">
        <property type="entry name" value="PTHR39178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04327">
        <property type="entry name" value="Peptidase_Prp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118010">
        <property type="entry name" value="SSF118010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN43655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP52194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS87697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="106" mass="11878" checksum="5D5ED248C45CFD94" modified="2016-09-07" version="1">MITITVKKRNGNYLEFVSKGHAGYAEEGQDIVCAAVSVLVINTVNSLETFTDDQFEVQEDDGYVSFHFTAPVTERGTLLMDSLILGLTEIEHSYNNRYLTVKVKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X2P0</accession>
    <name>A0A173X2P0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02650</name>
        <name evidence="2" type="ORF">ERS852478_00152</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052824.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45057">
        <property type="protein sequence ID" value="CUN45057"/>
        <property type="gene ID" value="ERS852478_00152"/>
    </dbReference>
    <dbReference type="GeneID" id="66495871"/>
    <dbReference type="eggNOG" id="ENOG50335DN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN45057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="122" mass="13221" checksum="C495744AC60A29F5" modified="2016-09-07" version="1">MLKNEERIAEVKRRIGEKERQQRLRHRRIVSAFCIAACLAVIVGVSFVMPGIVGQIEPGASSGFETAATILGGGTALGYMVIGLLAFILGVCVTVLCFRIRQLDKEEQTEEQKGDNGDGADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X8P0</accession>
    <name>A0A173X8P0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN47015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN47015">
        <property type="protein sequence ID" value="CUN47015"/>
        <property type="gene ID" value="ERS852478_00224"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN47015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="56" mass="6596" checksum="89196574C8A47EBD" modified="2016-09-07" version="1">MYEKGQEAERKNTERERQRADFAEKEKIKAPKETTEALKRVAELEKILQCKTTEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XAN6</accession>
    <name>A0A173XAN6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">srrB_1</name>
        <name evidence="7" type="ORF">ERS852478_00246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN48713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199521.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN48713">
        <property type="protein sequence ID" value="CUN48713"/>
        <property type="gene ID" value="ERS852478_00246"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="90"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN48713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="299" mass="32947" checksum="17155B782E0300D0" modified="2016-09-07" version="1">MNKTSIVIILLCFLAAAAVVLWERRKTRKTMEEIERMLDAAMTGSFSETNFDESQLSALETKFAHYLSAAEASSQNIAQEKDKIKTLIADISHQTKTPIANLLLYSELLMEETLPASAKANVEALYKQSEKLRFLIDSLVKLSRLENGIISLSPQQAALQPLLESVVEQYAAKASEKGLSLRLQDTDAFAVFDFKWTAEALANIVDNAIKYTEHGTITISAVSYEMFARVDISDTGSGIPETEQAKIFARFYRSKAVQEQEGVGIGLYLARQIISGEGGYIKIASVPGKGSTFSIFLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XEN8</accession>
    <name>A0A173XEN8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-arabinose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_00294</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577588.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50143">
        <property type="protein sequence ID" value="CUN50143"/>
        <property type="gene ID" value="ERS852478_00294"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008733">
        <property type="term" value="F:L-arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038583">
        <property type="entry name" value="AraA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003762">
        <property type="entry name" value="Lara_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38464">
        <property type="entry name" value="PTHR38464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02610">
        <property type="entry name" value="Arabinose_Isome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN50143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="472" mass="52056" checksum="7746508FEA4CD299" modified="2016-09-07" version="1">MLVNTKAKVGVFSIALGAYLPQFPSLVPEFESQYAAFKKTIPDTVEIIDGGMVTTKEQAMEAGDKFRAADVDLVFLQMLTYATSYNMLPAVRDLDVPVVLVNVQKLKALDYDHTDIASWLGEGYACGAVGEAVADLERAGKRHAVITGVVEGGDPGVQAEIEDWCKAAQVRRRFRDTNIAQIGRPYPGMMDLYIDETNLYNRMFLYTKQFDWEKMWAIADDITDEDAIRAKAQEILDTFEIEGGGTIEKVWDMAKYVVAFEKWVKDEHLGMIASHYDGFAQGKAGVLDSMLIPAFSMLIKQGTACAVEGDMKVAMAMSILKTISGTGQLSEMYSIDFNDDICIIGHSGSGDADISAKKPTMKIVKVFHGKTGGGYLTQFYPYTGPVTYLAITQDADGHFRFVVAEGVNEEGKILSFGDTNMRTRFTCGAREFVNRWSEAGPTHHMAAATGRHIETILKVAKIFNIPVEIVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XG21</accession>
    <name>A0A173XG21_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjO_1</name>
        <name evidence="7" type="ORF">ERS852478_00313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50751">
        <property type="protein sequence ID" value="CUN50751"/>
        <property type="gene ID" value="ERS852478_00313"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN50751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="299" mass="33532" checksum="F30982A56AA9AF70" modified="2016-09-07" version="1">MRTKKMKSQIKEAKTAWAMLTPALVVLALIQGYPILRTFWLSFHEMNLKRPQSGFPWIGISNYAKIFTDSRAGEDILFTLEFTVATVVLELIIGFAAALVMNRVFKGRGLVRAAILVPWAIPTSVSAMMWKFIYNDQYGMFNDILYRLGIIDGYKAWLSTTSGSFMAMVITDVWKTAPYMALLLLAGLQVIDEGLYEAAKIDGANVFQRFFKITLPIVKPSLLVALLFRTLDAFRVFDLVSVLTGGANGTESIAMYAYKQIMTFLDFGYGSALAILIFLIVFGISMIYMCFLKKDLTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XKG6</accession>
    <name>A0A173XKG6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator, effector-binding domain/component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_00325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199567.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51115">
        <property type="protein sequence ID" value="CUN51115"/>
        <property type="gene ID" value="ERS852478_00325"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03769">
        <property type="entry name" value="SR_IS607_transposase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041718">
        <property type="entry name" value="IS607_transposase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="6">
        <location>
            <begin position="60"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN51115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="214" mass="24861" checksum="3DB8DDF5DA51AAAF" modified="2016-09-07" version="1">MSKYYSIHEFSKIIGVSAQTLRNWDANGKLHPHHTTVSGYRYYSDEQLNQVINVKPKNRITIGYCRVSSHKQKDDLERQIDNVKTYLLAKGQPFEIISDIGPGINYKKKGLQELIRRISQNQVEKVVVLYKDRLLRFGFELIEYIASLYNCEIEIIDNTEKSEQQELVEDLVQIITVFSCKLQGKRANKAKKLIRELIQEETDGKSHKSNVDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XNS8</accession>
    <name>A0A173XNS8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52910">
        <property type="protein sequence ID" value="CUN52910"/>
        <property type="gene ID" value="ERS852478_00382"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023314">
        <property type="entry name" value="Myo_inos_IolC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN52910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="71" mass="8064" checksum="0883070B59BBDD02" modified="2016-09-07" version="1">MRAAIKEAGIDDIGLCTDEKIHTTLAMVHTYPDGDRDFSFYRNPGADMMLNKTEISEDILKETEMQISKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XSK2</accession>
    <name>A0A173XSK2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00397</name>
        <name evidence="3" type="ORF">ERS852523_01587</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000013">
        <property type="protein sequence ID" value="CUP42679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53338">
        <property type="protein sequence ID" value="CUN53338"/>
        <property type="gene ID" value="ERS852478_00397"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP42679">
        <property type="protein sequence ID" value="CUP42679"/>
        <property type="gene ID" value="ERS852523_01587"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP42679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="156" mass="17819" checksum="202B877F336579E1" modified="2016-09-07" version="1">MKIRKMKSNLDERQELKLLKIEHNGCWIAFWGLLIVMSIQMVMGNDSIKNLAGEWVVFMSLALYLSIDCLRNGIWDRKLKPNLKTNIIASSIAAVLAGIICFSVSYRNYHKLIGSIATGVIMFVQVEILCLIVLMISSKIYKRRVQKLEEDENPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XXY0</accession>
    <name>A0A173XXY0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted ATPase of the ABC class</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199653.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56459">
        <property type="protein sequence ID" value="CUN56459"/>
        <property type="gene ID" value="ERS852478_00470"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019195">
        <property type="entry name" value="ABC_ATPase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38149">
        <property type="entry name" value="PTHR38149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09818">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN56459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="576" mass="64834" checksum="4B927C8C592C82DF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y619</accession>
    <name>A0A173Y619_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative inner membrane transporter yiJE</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Uncharacterized inner membrane transporter yiJE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yijE</name>
        <name evidence="5" type="ORF">BWLFYP14_03317</name>
        <name evidence="4" type="ORF">ERS852478_00551</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX67040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59010">
        <property type="protein sequence ID" value="CUN59010"/>
        <property type="gene ID" value="ERS852478_00551"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="12"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="172"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN59010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX67040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="313" mass="33411" checksum="9C3FB78B5C248160" modified="2016-09-07" version="1">MQKQQIPLKNSLFLLLAAIIWGIAFVAQSVGMEYVGGFTFSAVRSLLGSVVLIPLILISGRKNSADTAATKANSFVGSSDGTVSSIRKRKDLIIGGISCGICLCLASNFQQFGIKYTTVGKAGFITACYIVIVPIIGLFLGKKCSKFIWAAVAMALIGLYLLCITDEFSIGKGDLLVLVCAFLFSIHILVIDHFSPKADGVKLSCIQFLTCGILSGIPALLFEHPEFSAICRAWMPILYAGIMSCGVAYTLQIIGQKNMNPTVASLILSLESCISVLAGWVLLGQQLSAKEILGCVIMFAAIILAQLPQKQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YCQ8</accession>
    <name>A0A173YCQ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hyaluronan synthase</fullName>
            <ecNumber evidence="2">2.4.1.212</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hyaD_1</name>
        <name evidence="2" type="ORF">ERS852478_00630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.212" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199724.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61724">
        <property type="protein sequence ID" value="CUN61724"/>
        <property type="gene ID" value="ERS852478_00630"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="84"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="341"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN61724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="635" mass="73152" checksum="0681E7DFEDD82498" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YCV9</accession>
    <name>A0A173YCV9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mreB_2</name>
        <name evidence="2" type="synonym">mreB</name>
        <name evidence="4" type="synonym">mreB_1</name>
        <name evidence="5" type="synonym">mreB_3</name>
        <name evidence="5" type="ORF">BWLFYP14_03251</name>
        <name evidence="3" type="ORF">ERS852478_00605</name>
        <name evidence="4" type="ORF">ERS852523_01818</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000016">
        <property type="protein sequence ID" value="CUP50023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX66974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706145.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000022_gene1741"/>
    <dbReference type="EnsemblBacteria" id="CUN60805">
        <property type="protein sequence ID" value="CUN60805"/>
        <property type="gene ID" value="ERS852478_00605"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP50023">
        <property type="protein sequence ID" value="CUP50023"/>
        <property type="gene ID" value="ERS852523_01818"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="284"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN60805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP50023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="329" mass="35219" checksum="FA7B78E4C948877B" modified="2016-09-07" version="1">MPTSDIGIDLGTRNSLAYSTGKGLVLNEPSIVVYDKNTEKIRAIGEEARLMEGRITSDMEIIRPIRQGVIVDYTVTEKMLKYFISRAIGRRAFRKPRISICVPSGITEIEKKAVEEATYQAGARDVYMVEEPIAAAIGAGVDVTKPFGNLVVDIGAGTSDVAVISLAGVVVSASVKVAGDTFNQAILNYVRKNHGLFIGEDMAEKIKIQIGTAIEESNPRTMEVKGRNVITGLPKTVTLTSEEIRVALKDATSQIVETVHGILEKTPPELAADIVDRGIVLTGGGALLHGMDTLIEQRTGVSTLTVQDAMSVVAVGTGKYAEVMARFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YD78</accession>
    <name>A0A173YD78_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase</fullName>
            <ecNumber evidence="3">2.4.2.53</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">arnC_2</name>
        <name evidence="7" type="synonym">arnC</name>
        <name evidence="7" type="ORF">BWLFYP14_03239</name>
        <name evidence="3" type="ORF">ERS852478_00617</name>
        <name evidence="4" type="ORF">ERS852523_01806</name>
        <name evidence="6" type="ORF">GT712_08525</name>
        <name evidence="5" type="ORF">GT728_05410</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.2.53" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000016">
        <property type="protein sequence ID" value="CUP49738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000009">
        <property type="protein sequence ID" value="MZL32657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000014">
        <property type="protein sequence ID" value="MZS89115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX66962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706126.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000022_gene1729"/>
    <dbReference type="EnsemblBacteria" id="CUN61197">
        <property type="protein sequence ID" value="CUN61197"/>
        <property type="gene ID" value="ERS852478_00617"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP49738">
        <property type="protein sequence ID" value="CUP49738"/>
        <property type="gene ID" value="ERS852523_01806"/>
    </dbReference>
    <dbReference type="GeneID" id="66492514"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099621">
        <property type="term" value="F:undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN61197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP49738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL32657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS89115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="311" mass="35852" checksum="1EDF7DB93DFA2DFD" modified="2016-09-07" version="1">MSLYSVVVPVYNSEHTLGELYTRLEKVFRETLKEDFELILVDDGSKDRSYEIMTELREKDHRVRIIQMARNFGQHPALLCGFAHVKGEFVVTMDDDLQHQPEELPKMVRTMQERPDVDVIIASYEGRKHGPIRKLGTKFSVWATSKMLGKDPDLQITSYRLIRRFLVDAMVKTNTYLPQIGNLLIRSSNRIINVPVQHADRAYGKSGYSFKRLLKDLIYDITTHTAFPLLLVRNIGIVSFLISVVLSVCYLVRYFTLGISVQGWTSLMLVMLAFFGLILLSIGIMGIYLMNILNEAKKMPHYVIRREDTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YF73</accession>
    <name>A0A173YF73_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molybdenum-pterin-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Molybdenum-pterin-binding protein 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Molybdenum-pterin-binding protein II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mopII</name>
        <name evidence="8" type="ORF">BWLFYP14_03211</name>
        <name evidence="4" type="ORF">ERS852478_00645</name>
        <name evidence="5" type="ORF">ERS852523_01777</name>
        <name evidence="7" type="ORF">GT712_08665</name>
        <name evidence="6" type="ORF">GT728_16905</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">2789STDY5834863</strain>
            <strain evidence="5 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 13">BIOML-A1</strain>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN62180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000016">
        <property type="protein sequence ID" value="CUP48967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000054">
        <property type="protein sequence ID" value="MZL34823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000014">
        <property type="protein sequence ID" value="MZS89142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX66935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706085.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000054.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000063_gene708"/>
    <dbReference type="EnsemblBacteria" id="CUN62180">
        <property type="protein sequence ID" value="CUN62180"/>
        <property type="gene ID" value="ERS852478_00645"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP48967">
        <property type="protein sequence ID" value="CUP48967"/>
        <property type="gene ID" value="ERS852523_01777"/>
    </dbReference>
    <dbReference type="GeneID" id="66492542"/>
    <dbReference type="eggNOG" id="COG3585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00638">
        <property type="entry name" value="Mop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN62180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP48967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL34823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS89142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="70" mass="7160" checksum="79A31FFF54360140" modified="2016-09-07" version="1">MKLSARNQLKGKVVSINNGAVNSIVSIDIGGGNIITATISCAAVEELNLKVGSDAYAVIKATNVMVGIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YT22</accession>
    <name>A0A173YT22_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cysteine metabolism repressor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">HTH-type transcriptional regulator CymR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Rrf2 family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cymR_1</name>
        <name evidence="2" type="synonym">cymR_2</name>
        <name evidence="4" type="ORF">BWLFYP14_01762</name>
        <name evidence="1" type="ORF">ERS852478_00758</name>
        <name evidence="2" type="ORF">ERS852523_00584</name>
        <name evidence="3" type="ORF">GT712_02965</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
            <strain evidence="2 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP11362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706458.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000036_gene2407"/>
    <dbReference type="EnsemblBacteria" id="CUN67074">
        <property type="protein sequence ID" value="CUN67074"/>
        <property type="gene ID" value="ERS852478_00758"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11362">
        <property type="protein sequence ID" value="CUP11362"/>
        <property type="gene ID" value="ERS852523_00584"/>
    </dbReference>
    <dbReference type="GeneID" id="66493533"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN67074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP11362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS88072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="144" mass="16263" checksum="A477EEEA16F25666" modified="2016-09-07" version="1">MQISTKGRYALRLMLDLAVHNTGELVKIKDISARENISEKYLEQIISSLKKAGYVKSLRGAQGGYMLAREPETYTVGTILRLTEGSMKPVACLEDEPNQCSRAGECVTLRLWKMLDEAIEGVLDKVTLQDLKDWYEEMGNDYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YY76</accession>
    <name>A0A173YY76_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted DNA-binding protein with PD1-like DNA-binding motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_01703</name>
        <name evidence="2" type="ORF">ERS852478_00809</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199807.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68934">
        <property type="protein sequence ID" value="CUN68934"/>
        <property type="gene ID" value="ERS852478_00809"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN68934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX64846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="145" mass="16429" checksum="0A1612AA0448AF0B" modified="2016-09-07" version="1">MDYRKFGECYYIRMDRDDEIISTILEICKKENVRSATFSGIGGCKDAKIQTFIPETGSFEEQRISGMLELVSLNGNVVTGENNICYHHTHAAFSYKDGERHCMAAGHMKSITVLYTAEIELRPVTGGTIHRKYDPETGTGFWDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YYA8</accession>
    <name>A0A173YYA8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative TrmH family tRNA/rRNA methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199811.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69212">
        <property type="protein sequence ID" value="CUN69212"/>
        <property type="gene ID" value="ERS852478_00818"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="121"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN69212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="272" mass="30091" checksum="8002CD23E322ABEF" modified="2016-09-07" version="1">MFNEIKDFAAPELDVYARTSEVQLLRYYEPKPGIFIAESPKVIERALKAGYQPISFLVEHKDLEGEAQEILKQYPDVPVYTAEYELLVKLTGFALTRGMLCSMRRNPLPSVEEICRNASRIAVLENVVNPTNIGAIFRSAAALHMDAVLLTGGCSDPLYRRAARVSMGTVFQIPWTYFDKKTVWPQDGMQILQNLGFKTAAMALRDDSVGIDDKALRSEEKLAVILGTEGDGLASQTIADCDYTVKIPMSHGVDSLNVAAASAVAFWELGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z5A8</accession>
    <name>A0A173Z5A8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative septation protein SpoVG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">spoVG</name>
        <name evidence="7" type="synonym">spoVG_2</name>
        <name evidence="7" type="ORF">BWLFYP14_01245</name>
        <name evidence="5" type="ORF">ERS852478_00863</name>
        <name evidence="6" type="ORF">GT728_01050</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Could be involved in septation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SpoVG family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053372.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71511">
        <property type="protein sequence ID" value="CUN71511"/>
        <property type="gene ID" value="ERS852478_00863"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00819">
        <property type="entry name" value="SpoVG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007170">
        <property type="entry name" value="SpoVG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036751">
        <property type="entry name" value="SpoVG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38429">
        <property type="entry name" value="PTHR38429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04026">
        <property type="entry name" value="SpoVG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160537">
        <property type="entry name" value="SSF160537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0717">Septation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN71511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL31818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX64123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="95" mass="10685" checksum="9DB16857ABB02735" modified="2016-09-07" version="1">MNITDVRVRKVAKEGKMKAVVSITIDDEFVVHDIKVIEGEKGLFIAMPSRKATDGEYRDIAHPINSATRDRIQTIILDKFQEVMDAEPEEAAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZCS0</accession>
    <name>A0A173ZCS0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II toxin-antitoxin system HicB family antitoxin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein family (UPF0150)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_01323</name>
        <name evidence="2" type="ORF">ERS852478_00952</name>
        <name evidence="3" type="ORF">ERS852523_01180</name>
        <name evidence="5" type="ORF">GT712_09550</name>
        <name evidence="4" type="ORF">GT728_01440</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000009">
        <property type="protein sequence ID" value="CUP30052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707065.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000090_gene2560"/>
    <dbReference type="EnsemblBacteria" id="CUN74172">
        <property type="protein sequence ID" value="CUN74172"/>
        <property type="gene ID" value="ERS852478_00952"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP30052">
        <property type="protein sequence ID" value="CUP30052"/>
        <property type="gene ID" value="ERS852523_01180"/>
    </dbReference>
    <dbReference type="GeneID" id="66493714"/>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031807">
        <property type="entry name" value="HicB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15919">
        <property type="entry name" value="HicB_lk_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HicB-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN74172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP30052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL31896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX64279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="92" mass="10638" checksum="F4186EEA5D27B416" modified="2016-09-07" version="1">MKFIYPAVFRKNEEGRYKAFFPDLACCEAEGDTLDDAIDNANEAAYNWIYAEVMEDEMDLPAISDESDLDLLEGDIVRNIQVNIRMYDGWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZIP0</accession>
    <name>A0A173ZIP0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA primase</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaG_2</name>
        <name evidence="6" type="ORF">ERS852478_01011</name>
        <name evidence="7" type="ORF">GT728_13535</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000034">
        <property type="protein sequence ID" value="MZL34199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707134.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76104">
        <property type="protein sequence ID" value="CUN76104"/>
        <property type="gene ID" value="ERS852478_01011"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZnF_CHCC" evidence="5">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN76104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL34199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="234" mass="26717" checksum="4F6B4DA676631184" modified="2016-09-07" version="1">MNIFEAVKQSVTTRQAAESYGIRVNKNGMAVCPFHRDKNPSMKVDRRFHCFGCQADGDVIDFTAHLYNLKPKEAAEKLARDFSIHYENMGHSPPQRKQIKRQLTQEQRYLQAENRYFRALADYLHLLKQWKEECAPKQVEDVWHPLFMEALEKISETEYLLDTLLSGTLEERVAVVVAHGKEVTAIEQRISDFITTDTTGIVRSNGYNGNGVDSRGNQRTTGNDTEGCCEKQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZK64</accession>
    <name>A0A173ZK64_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nickel-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nikA_2</name>
        <name evidence="5" type="ORF">ERS852478_01028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199885.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76614">
        <property type="protein sequence ID" value="CUN76614"/>
        <property type="gene ID" value="ERS852478_01028"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016959" evidence="3">
        <location>
            <begin position="29"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="73"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN76614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="518" mass="57882" checksum="F66EF1C43DB06E20" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZMZ4</accession>
    <name>A0A173ZMZ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted aminopeptidase, Iap family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76980">
        <property type="protein sequence ID" value="CUN76980"/>
        <property type="gene ID" value="ERS852478_01041"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034308">
        <property type="entry name" value="VPS70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="PTHR10404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="PTHR10404:SF46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="252"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN76980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="704" mass="80185" checksum="9ADEBC56A15EA127" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZN58</accession>
    <name>A0A173ZN58_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Penicillinase repressor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Regulatory protein BlaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">blaI_3</name>
        <name evidence="3" type="synonym">blaI_2</name>
        <name evidence="6" type="ORF">BWLFYP14_01426</name>
        <name evidence="2" type="ORF">ERS852478_01043</name>
        <name evidence="3" type="ORF">ERS852523_02907</name>
        <name evidence="5" type="ORF">GT712_17200</name>
        <name evidence="4" type="ORF">GT728_13685</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN77040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000035">
        <property type="protein sequence ID" value="CUP81654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000034">
        <property type="protein sequence ID" value="MZL34229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000049">
        <property type="protein sequence ID" value="MZS90746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707184.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000103_gene865"/>
    <dbReference type="EnsemblBacteria" id="CUN77040">
        <property type="protein sequence ID" value="CUN77040"/>
        <property type="gene ID" value="ERS852478_01043"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP81654">
        <property type="protein sequence ID" value="CUP81654"/>
        <property type="gene ID" value="ERS852523_02907"/>
    </dbReference>
    <dbReference type="GeneID" id="66493836"/>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN77040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP81654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX64485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="124" mass="14251" checksum="56CE9B13CF24E70B" modified="2016-09-07" version="1">MVRNAMSATEFYILQYLWTRETPATFSEIMVHFNEEEKKAWKKQTVNTFLSRLAQKGFLNIDKSGKRAIYIPSVTSKKFYENYAQEIVKDSYNGAIKDFIAAFTAGNKLSAAEKAELLSYIQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZS46</accession>
    <name>A0A173ZS46_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
            <ecNumber evidence="11">2.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">miaB_2</name>
        <name evidence="11" type="ORF">ERS852478_01071</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199912.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79101">
        <property type="protein sequence ID" value="CUN79101"/>
        <property type="gene ID" value="ERS852478_01071"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:N6-threonylcarbomyladenosine methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006467">
        <property type="entry name" value="MiaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034557">
        <property type="entry name" value="ThrcA_tRNA_MEthiotransferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00295">
        <property type="entry name" value="threonylcarbamoyladenosine_tRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01579">
        <property type="entry name" value="MiaB-like-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="140"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN79101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="443" mass="50268" checksum="F39402F28DC774A8" modified="2016-09-07" version="1">MGKKVALHNLGCKVNAYEVEAMQQLLEEAGYEIVPFEPGADVYLINTCTVTNIADRKSRQMLHKAKKMNPDAIVIAAGCYVQTDEGKLDKDEAVDLILGNNQKGNIVQVLEEYEQQHTRQKHVLKINQTKEYEELAIDHTAEHVRAYIKVQDGCNQFCTYCIIPYARGRVRSRKIAHVMDEVHALASKGYKEVVLTGIHLSSYGVDFPAEEKETLLSLIRAVHEVEGIERIRLGSLEPGIITEEFVQSIAALPKMCPHFHLSLQSGCDTTLERMNRRYRSAEYAEKCGLLRKYLGNPALTTDVIVGFPMETEEDFQDSYDFVESIHFYETHIFKYSRRHGTKAAAMSGQLTEAQKAVRSDKMLALNEQHAKEYEKSMLGGELKVLLEEEVEINGEQWYIGHSMEYIKTAVKKQDNYSVNDIITVKAEEFLEEHTLTGEVLGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A5M8</accession>
    <name>A0A174A5M8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein M</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057377.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82826">
        <property type="protein sequence ID" value="CUN82826"/>
        <property type="gene ID" value="ERS852478_01177"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZK4M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN82826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="197" mass="22311" checksum="227BD14259E024F8" modified="2016-09-07" version="1">MKKNRTGTKKFPALILFLLGFLAGNLIPNIIWKAKWQQKTWASVYFLSTFAGKNTGNIEYLKEILKYRGVFYLLNIICGFSIFGAPLAVITLLGSGLYAGMIMTVSILEFGFAGGVIGMGLLLPQYLFYIPVWLYSMEQEWKISSEIWRNRGLISGEVSIYLKKMCIAAVGYFLGILIECYVNPLIIDIILKYIKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A7M4</accession>
    <name>A0A174A7M4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 16">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 16">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">hom_1</name>
        <name evidence="19" type="ORF">ERS852478_01196</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 16"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199953.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83506">
        <property type="protein sequence ID" value="CUN83506"/>
        <property type="gene ID" value="ERS852478_01196"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0460">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 16" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 15 16" id="KW-0521">NADP</keyword>
    <keyword evidence="12 16 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="18">
        <location>
            <begin position="352"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CUN83506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="431" mass="46971" checksum="F1C93F61A6E11795" modified="2016-09-07" version="1">MNENVIKAALLGFGTVGTGVYKVLKNQEKEMSAKIGCKVEIKKILVRNIEKAAAKIEDASLFTSQWDEIINDPEIEIVIELMGGINPAKEYILSALKAGKHVVSANKDLIAVHGHELLDAAHESKVDFLFEAAVAGGIPIIRPLKQCLAGNHMTEVMGIVNGTTNFILTKMTQEGMEFKDALALATELGYAEADPTADIEGLDAGRKVAILASVAFNSRVVFNDVYTEGIAKITSKDIHYAKEMGRDIKLLGVARNEADGIEAYVCPMLIPSSHPLATVNDSYNAVFVHGDAVEDAMFFGRGAGELPTASAVVGDVFDIVRNILAGCCGRIGCTCYKNIPVKKMEDTHNRYFLRLKVEDRCGVLAEMTAIFAKYQVSVAQIIQKDTKVEGCAEVVVITEKVREGDFRTAIEELRNRDSVRKISTIIRVYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AGP6</accession>
    <name>A0A174AGP6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199991.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86668">
        <property type="protein sequence ID" value="CUN86668"/>
        <property type="gene ID" value="ERS852478_01252"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN86668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="299" mass="34340" checksum="D38F6CAFDAF0ABAC" modified="2016-09-07" version="1">MFPEVEVYRYVTEQTFDAYLYQLVESKQKFISQIMTSKSPVRSAEDVDEVALSFAEVKMLATGDARFKEKMDLDIQVSKLRVLKQSYLSEHYDLEDRVLKYYPQTIKEYEERIAGYENDAALAEQHKPQGEDKFCPMTLKGVTYTEKADAGEMLLAICKDYPMSAATEIGSYRGFRIEIYYDTVNAHYCMNLCGKTKHKVDLGSDALGNLTRIENELSKLPARLEAAKTKKAEIIAQLEIAKAEIKKPFAFEDELKEKTERLNALNIELNLNEKDTSVMDTEPEQAEEQPERKCASRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AKJ6</accession>
    <name>A0A174AKJ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">glyA</name>
        <name evidence="10" type="ORF">ERS852478_01289</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380392.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87986">
        <property type="protein sequence ID" value="CUN87986"/>
        <property type="gene ID" value="ERS852478_01289"/>
    </dbReference>
    <dbReference type="GeneID" id="66494952"/>
    <dbReference type="eggNOG" id="COG0112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
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        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="8"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="353"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
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        </ligand>
    </feature>
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        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
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        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN87986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="412" mass="44510" checksum="74963EC3C55E9D67" modified="2016-09-07" version="1">MYSIDDVAKTDKDIADLIEAELARQNSHIELIASENWVSKAVMAAMGSPLTNKYAEGYPGKRFYGGCSCVDEVEALAIERAKELFGCEYANVQPHSGAQANMAVFFAMLQTGDTVMGMNLDHGGHLTHGSPANMSGTYFKPVYYGVNDDGVIDYEEVRRIAIENKPKLIVAGASAYARVIDFKKFREIADEVGAYLMVDMAHIAGLVAGGQHPSPIPYADVVTTTTHKTLRGPRGGLILSSAENAKKFNFNKAVFPGIQGGPLMHVIAAKAVCFKEALQPEFKDYAKMIVENAQALCKGLQKRGIDIVSGGTDNHLMLVDLRSLGVTGKQMENLLDEVNITCNKNAIPNDPQSPFVTSGVRLGTAAVTSRGMKPEDMDKIAEAIAMTLKEEGSQEKAKAIVKELTDKYPLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ALE5</accession>
    <name>A0A174ALE5_9FIRM</name>
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        <submittedName>
            <fullName evidence="2">Maltose-binding periplasmic proteins/domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUN89571"/>
        <property type="gene ID" value="ERS852478_01332"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="SBP"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017746" evidence="1">
        <location>
            <begin position="25"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUN89571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="415" mass="47636" checksum="049A20743524EFA2" modified="2016-09-07" version="1">MKKSVVIFITAVCLLITGCGDTGSLSKLPSSSFHEDKQKLTIMHIDADNKRFQDFIEETEKKLDMEITVEKCPSNADNRQAKISTILASGDKNIDLISVNDEMISEFKHKGYLEPLEKNVMTEEVRDSFPQKYLESICEENGHIYSVPFQMDIMMFWVNQELLKQAGLDEIKNTGDFDILQKSLKNPDQYAYGDAWENTHVYNSLSQFVNFWGGDYFDWTDPKTKDAARYMKSMLDEKNTSPAQFVDQYEQMEEKFIRGKYGCVFMYTSALGTFLDADVYGKNKIHMAPLPVLHKKKATNIATWQYVLNNASENKDAAVRFLQYAAGYEGSTEYAKIMKSYPARVDVIENEDIDLEGIDMIRKYLREYTLNARPLCENSMGAVSDMGKLFQGYVLGQCEEDSFFEQAQNCINTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174APJ4</accession>
    <name>A0A174APJ4_9FIRM</name>
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        <submittedName>
            <fullName evidence="5">RNA polymerase sigma factor sigV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sigV_2</name>
        <name evidence="5" type="ORF">ERS852478_01362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
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    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90424">
        <property type="protein sequence ID" value="CUN90424"/>
        <property type="gene ID" value="ERS852478_01362"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
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    </dbReference>
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        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="3">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="4">
        <location>
            <begin position="107"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN90424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="198" mass="23294" checksum="0599E5DE03B615EE" modified="2016-09-07" version="1">MIQLVKRSISGDADAFLELMEKNSLAMYKVARGILDNDEDAADAMQDTILTCFEKIHTLKNPEYFKTWMIRILINECNKIHRHYKNFSRAEELPEVPGQDMSIEEFEFKEMLGMLDESYRIILVLYYVEGFRIADIASILNMNENTVKTRLVRARMQLKQEYTSAEDNIQKKRLQQKKKKNREFTGIAEGLQNIRMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B019</accession>
    <name>A0A174B019_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200075.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93559">
        <property type="protein sequence ID" value="CUN93559"/>
        <property type="gene ID" value="ERS852478_01421"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN93559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="117" mass="13823" checksum="7F069CEF4B1F04B7" modified="2016-09-07" version="1">MKEVIFYLCGIFSCMIVWFLWAVIASKKAKEAPLKEYARIHTDIEKAIRENEEQIVIAKKYQVVEDQVIDQMILQWKIEYLQSQRAWLFTLLGGKMEDSYVQQMSEMRKETDGSGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B0P9</accession>
    <name>A0A174B0P9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93225">
        <property type="protein sequence ID" value="CUN93225"/>
        <property type="gene ID" value="ERS852478_01411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN93225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="69" mass="8171" checksum="BF697FFB74F87351" modified="2016-09-07" version="1">MEYSITASDIAKRIGCDRQDIYSSASYGLLIKKEYYVEITDRPLSWKKDIDLLTEYDNVRKKFLRRCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B1D9</accession>
    <name>A0A174B1D9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93455">
        <property type="protein sequence ID" value="CUN93455"/>
        <property type="gene ID" value="ERS852478_01417"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN93455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="81" mass="9411" checksum="B39D9D42E60F2967" modified="2016-09-07" version="1">MSRDDYAFHCAGCRCNHCANNVETGDNCAGEAIKACFVCDECNWYDGNFKNRDMTCRQCEDYIVTNQHAEHLRKRIKVIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B8X8</accession>
    <name>A0A174B8X8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division protein FtsW</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">FtsW/RodA/SpoVE family cell cycle protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Lipid II flippase FtsW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ftsW_3</name>
        <name evidence="11" type="synonym">ftsW_1</name>
        <name evidence="11" type="ORF">BWLFYP14_00978</name>
        <name evidence="8" type="ORF">ERS852478_01500</name>
        <name evidence="10" type="ORF">GT712_13050</name>
        <name evidence="9" type="ORF">GT728_11005</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 15">BIOML-A1</strain>
            <strain evidence="10 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000024">
        <property type="protein sequence ID" value="MZL33712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000026">
        <property type="protein sequence ID" value="MZS89973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380997.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96220">
        <property type="protein sequence ID" value="CUN96220"/>
        <property type="gene ID" value="ERS852478_01500"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN96220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS89973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX63492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="457" mass="50645" checksum="5203E15BE2140C0F" modified="2016-09-07" version="1">MINVIVELSKYVILTLMVIYTFHCFYLVKQQSEEERNESLRQQLMLIFFMDFTAFLVIYLKTGKFQVVLFYIEMMAFFAGIQILYRIFYKKASILLLNNMCMLLSVGFIMLCRLDVSTATRQLVIVAGVNVVALIVPVLIRKMKFLKDLTWVYAGIGIVLLAAVFVLAKTSYGAKLSLMGIQPSEAIKITFVFFMAALLRKGADFSKVVQATVVAGLHVGILVLSRDLGSAVIFFAAYLVMIYVASRNVGYLALGLAGGSAGAVVAYHLFGHVRQRVTAWKDPMAVYQNEGYQIVQSLFAIGTGGWFGMGLCQGSPEKIPVVKNDFIFSAICEELGGIFAICLILVCMSFFLMIVNIALKIKKPFYKLIALGLGTEYAFQVFLTIGGATKFIPMTGVTLPLVSYGGSSVACTVLMLAIIQGLYILREDEDEEIERYRRKGTAQRVEEAPEAQSPGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BJF2</accession>
    <name>A0A174BJF2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anti-sigma F factor antagonist</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">STAS domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein AA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoIIAA</name>
        <name evidence="6" type="ORF">BWLFYP14_00239</name>
        <name evidence="2" type="ORF">ERS852478_01574</name>
        <name evidence="3" type="ORF">ERS852523_01311</name>
        <name evidence="5" type="ORF">GT712_09065</name>
        <name evidence="4" type="ORF">GT728_04615</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP34136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994122.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000057_gene2524"/>
    <dbReference type="EnsemblBacteria" id="CUN99728">
        <property type="protein sequence ID" value="CUN99728"/>
        <property type="gene ID" value="ERS852478_01574"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP34136">
        <property type="protein sequence ID" value="CUP34136"/>
        <property type="gene ID" value="ERS852523_01311"/>
    </dbReference>
    <dbReference type="GeneID" id="66496105"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN99728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP34136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX67398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="104" mass="11926" checksum="01E3475BB5B9FE64" modified="2016-09-07" version="1">MENRFEIQGNSLIIHLPKEVDHMVTDEIRRDSDDIIRKKYIRTITFDFSGTAFMDSSGIGLIMGRYRMMGMRGDCIQATGVNSYIEKLLHLSGVYKFVEICGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BZ52</accession>
    <name>A0A174BZ52_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO04915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009247528.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO04915">
        <property type="protein sequence ID" value="CUO04915"/>
        <property type="gene ID" value="ERS852478_01705"/>
    </dbReference>
    <dbReference type="GeneID" id="61850129"/>
    <dbReference type="GeneID" id="66882339"/>
    <dbReference type="eggNOG" id="ENOG50330IM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO04915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="62" mass="7288" checksum="2EF14CE5098AC264" modified="2016-09-07" version="1">MENRFIRAEDVAQELNVSKPYAYKLIRQLNEELKAKGFITIAGRVNRQYFYERLYGAGKGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C4Q8</accession>
    <name>A0A174C4Q8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_12</name>
        <name evidence="7" type="ORF">ERS852478_01761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06748">
        <property type="protein sequence ID" value="CUO06748"/>
        <property type="gene ID" value="ERS852478_01761"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO06748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="281" mass="31054" checksum="B2E57BFBFACDE367" modified="2016-09-07" version="1">MGAVKKKNRLGHRDRSWKIFLAVMAVIALIPLVYALSLSVRTQNSIYDPRLFVTDLTIGNYIKAISDNPTILNNFISSLVISVISTAATVLCASMAVYGFSRKNVYGKVIMYNLILCTLMVPISALVIPITQLNSRMGLLDNYFGLIFPYIALNIPYAVTILQGFMKGVPKELEEAAGLDGCNIVQLYTRIVMPMLKPGIVVVAIWTFLTCWNEFFLALCTMTKATTKTLPLIAQQYKGVYNSQPGILFAILIIITIPMVIFYCVVQKQFVKGMTAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C607</accession>
    <name>A0A174C607_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lacE_2</name>
        <name evidence="2" type="ORF">ERS852478_01827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200308.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08862">
        <property type="protein sequence ID" value="CUO08862"/>
        <property type="gene ID" value="ERS852478_01827"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008018989" evidence="1">
        <location>
            <begin position="28"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO08862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="429" mass="47322" checksum="8C4CA0BB76DA0C1E" modified="2016-09-07" version="1">MRKKLLAVLMTGAMVASFAGSATAVFAKSDDDNKLTVWAWDQNFNIKSMKIAADQYAKDHEGFSVDIVETSSDDCQTKLTTAANAGDYSTLPDIVLMQDNSYQKYLKSYPDAFTDLKDININWDDFGKLKQSYSMVDDTHYGVPFDNGAVIACYRTDILDEAGYTIDDLTDITWSKFMEIGKDVHEKTGKYLLTSEATGGDTLMMMMQSCGANFVNEDGEAYIVGNEVAEKCINLYVDLVKNDVVKLVNNWDEYIATITGGEAAGIVNGNWITATLMSTEDQKGLWQITTMPKVDDVDTATNYANNGGSSWYVTSNCQNVELAEDFLASTFGSSTDFYDAILPEAGAISCYLPAGESKVYNEPNEFFGGQPIFSTIVEYSSHIPEFTKTPYHYEARECVNTAVVNIVNGTPVEDALQEAQDTLAFKMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C9G4</accession>
    <name>A0A174C9G4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO09794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200331.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09794">
        <property type="protein sequence ID" value="CUO09794"/>
        <property type="gene ID" value="ERS852478_01834"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO09794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="98" mass="11301" checksum="44599C4E795C673F" modified="2016-09-07" version="1">MIISIPCKFGEKALCRRMLVFCGVDWFRWSSGMEYTYFFETGDFWHEADFYTGDGAGMSKYIEVDNVLLSSFVLREKGLPLRGEGSVEGFRFKNGKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C9W7</accession>
    <name>A0A174C9W7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO09763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200329.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09763">
        <property type="protein sequence ID" value="CUO09763"/>
        <property type="gene ID" value="ERS852478_01833"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO09763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="86" mass="9923" checksum="2F4F7ACC12B6DAF3" modified="2016-09-07" version="1">MKVIFLDTDGVLTHTDYLNWQTRHIDPEKVLEQIPSVISLDQLDIHCKHRTGRAAEVEKWLIRNMTCSTVSSVFLECRGDKTGIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CDQ6</accession>
    <name>A0A174CDQ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">recJ_1</name>
        <name evidence="9" type="ORF">ERS852478_01844</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200345.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10110">
        <property type="protein sequence ID" value="CUO10110"/>
        <property type="gene ID" value="ERS852478_01844"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="6">
        <location>
            <begin position="76"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="7">
        <location>
            <begin position="323"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="8">
        <location>
            <begin position="459"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO10110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="570" mass="63929" checksum="B359A8CB38DD2BD8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CE00</accession>
    <name>A0A174CE00_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_01856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200369.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10489">
        <property type="protein sequence ID" value="CUO10489"/>
        <property type="gene ID" value="ERS852478_01856"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="153"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO10489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="386" mass="44269" checksum="84230E0F27FB0FCD" modified="2016-09-07" version="1">MMKGVQYFRTRITDVDGKRVAIYGLTREELYDREEDAQKKIAEVVFHRENPTVEEYCEKWLLMRSGTVRTNTLEGYARMVNRYIVGPIGQMYMDEVTTDDLRLLMVPLSKGSSGIYGQLNMLIKNIFNSAEESKVIKENPSKTICARGGKPAKRREALTDEQTAILLDSIRELPPYVFVMIGLYAGLRREEILGLKWDCVFLDEKTPYISVRRAWHVEGGEPVVNTLLKTPAAKRDVPIPKCLVACLKEARGKSESEYVISNSKGTVLTETQFVRVWKYITVRSTAERCYYTYVNGQSIKHRIKPRLGEHQPNNPKLVYTMDFKVTLHMLRHTYITNLIYKGVDPKTVQYLAGHENSKTTMVIYAKVKYNKPEELSSVVNAAFGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CJE9</accession>
    <name>A0A174CJE9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02176</name>
        <name evidence="2" type="ORF">ERS852478_01957</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13651">
        <property type="protein sequence ID" value="CUO13651"/>
        <property type="gene ID" value="ERS852478_01957"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033255214" evidence="1">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO13651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="68" mass="7584" checksum="94248CBA479E8BE8" modified="2016-09-07" version="1">MLPNALLLCLFKMKFLKSLKPQNAASSFFDFDVVQKAKICLDTVDDSGSCLSARFSNGINLLDLRTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CK40</accession>
    <name>A0A174CK40_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CDP-glycerol:poly(Glycerophosphate) glycerophosphotransferase</fullName>
            <ecNumber evidence="6">2.7.8.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tagF_3</name>
        <name evidence="6" type="ORF">ERS852478_01912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.12" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200432.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12168">
        <property type="protein sequence ID" value="CUO12168"/>
        <property type="gene ID" value="ERS852478_01912"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO12168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="419" mass="49146" checksum="E83A4CD2C8DF530C" modified="2016-09-07" version="1">MTKSAIKKYTERLGFFGMILHYIGRLMTKTEQQVIGKLTVRFGKVKKNRLVFKNREMMDCTDNPEAFYEYLISSGYNKKYEIIWLVSEKRKFRNQNTGNVKFVTAENKYGWSSPLAYYYGATAGFFFYSHNSAGLNRYRCKGQTVVNLWHGCGYKDAEQGKKKQNIKPDFDYALVPGPVFVKTKSGLWNCEPDRLLMMGYPRYDWMLHPSMSKDEILDSLFGWKGKKAVLWMPTFRKSDLGGCAENEIELPCQLPAIQDMNELKELDSYLREQEIILIIKKHPLQTEWDENEQEFTNIRYVAEALLEKKQIKLYELIGISDGLLSDYSSVAVDYLLLDRPLGYVLADYNIYKEKRGFVFEDPLEYMPGEKIYNACDIRKFMKHLTDGTDSYRQERAKNLKQMHNKTENYCKRLADYLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CKL4</accession>
    <name>A0A174CKL4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ECF RNA polymerase sigma factor SigH</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor sigV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sigV_3</name>
        <name evidence="5" type="synonym">sigH_2</name>
        <name evidence="5" type="ORF">BWLFYP14_02177</name>
        <name evidence="4" type="ORF">ERS852478_01956</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703599.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13624">
        <property type="protein sequence ID" value="CUO13624"/>
        <property type="gene ID" value="ERS852478_01956"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="14"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="99"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO13624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="162" mass="18757" checksum="4FBB7F2DC250A9AD" modified="2016-09-07" version="1">MTKEELGTLILNSERQLYSTAKTILINDQDCADAIQETIVKAFSKIGTLRNDKYAKTWLIRILINECYTLLRKSSKLVSLEGMSEMTEIETDQRTDYSDLYRAVNSLKEELRMPVILYYIEDFNIKEIAQILEITEGAVQKRLARARGKLKRNLQESEELTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CPQ9</accession>
    <name>A0A174CPQ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13798">
        <property type="protein sequence ID" value="CUO13798"/>
        <property type="gene ID" value="ERS852478_01962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO13798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="38" mass="4365" checksum="8A1940704EC316EB" modified="2016-09-07" version="1">MTKKVILFLVEGPTDEDALAVIFTKLVNDHERNILMHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D1G8</accession>
    <name>A0A174D1G8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphorylated carbohydrates phosphatase TM_1254</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19344">
        <property type="protein sequence ID" value="CUO19344"/>
        <property type="gene ID" value="ERS852478_02094"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO19344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="217" mass="24475" checksum="9E7F7AF9903200EE" modified="2016-09-07" version="1">MKAAIFDVDGTLLDSMSVWEDIGERYLASQNITAEKNLRATLHTMSLEQGAAWMKEKYQLDKSISQIIEEVLKIVSDFYRFEASLKPGVKKTLEWFKERNIQMTVATSGNRELTEAALARNGILDYFEQIYTCTETGAGKDEPLIYLKAAESMQAEPNETLVFEDALHAAETAKKAGFVVVGVYDEENRKNISKMKEVCDCYCDRIDAAIENICLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DA10</accession>
    <name>A0A174DA10_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200578.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20870">
        <property type="protein sequence ID" value="CUO20870"/>
        <property type="gene ID" value="ERS852478_02143"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045507">
        <property type="entry name" value="DUF6483"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20092">
        <property type="entry name" value="DUF6483"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO20870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="131" mass="15508" checksum="39428AC7763D45DD" modified="2016-09-07" version="1">MNFTDEKDYIMRMIKEMVRVLFSLAFGKKYVSVELEKENKYEVSGKNLKNFLNMIDLGQINEAENILLDSIDYTNKNEVMAVALFYQYLSEKDNQFLENNNYTKEEVLSGFKQLLMKSGYSDLLYLLKYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DI37</accession>
    <name>A0A174DI37_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage 0 sporulation protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spo0A_2</name>
        <name evidence="3" type="ORF">ERS852478_02265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200664.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25104">
        <property type="protein sequence ID" value="CUO25104"/>
        <property type="gene ID" value="ERS852478_02265"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042173">
        <property type="term" value="P:regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014879">
        <property type="entry name" value="Spo0A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08769">
        <property type="entry name" value="Spo0A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spo0A_C" evidence="2">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO25104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="109" mass="12686" checksum="7605DF61022E195A" modified="2016-09-07" version="1">MSAVYGVIRKLGATSKYKGYYYVVDAVEMAQKIYERPVKVTKDIYPVIARKYKSTPSNVEHNIRTLVNLCWMNHKDTLEEMAGCTMADKPTNNEFIDILVYYLRYSDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DVE5</accession>
    <name>A0A174DVE5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-methylgalactoside transporter inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_02386</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29552">
        <property type="protein sequence ID" value="CUO29552"/>
        <property type="gene ID" value="ERS852478_02386"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO29552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="308" mass="32368" checksum="311C3604AC0193DB" modified="2016-09-07" version="1">MTIATILSLGETALKLGLICSLTVLALFLSYSMLNVCDLSTDGCFTLGAAVGAAVAVSGHPFLSIFAAMAAGICSGFVTAILQTKLGVDSLLAGIIVNTALYSVNIAVMGGSSLINMNRTETVFSMTKETLKSTPLKGRGDIVVAFIAVAIVIVFLVFFLRTRLGLAIRATGNNADMVKSSSINPVFTTIVGLCVANSFTALSGCLLSQSQKSVDINIGQGMVTIALASLLIGGTILGRGGIFVRAVGMVLGSFIFRLVYTVALRFNMPAFMLKLVSSVIVVLAISGPYLKKQWPQIKRRMTHRKGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DVH9</accession>
    <name>A0A174DVH9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence damage-inducible protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ygaD</name>
        <name evidence="2" type="ORF">ERS852478_02339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28045">
        <property type="protein sequence ID" value="CUO28045"/>
        <property type="gene ID" value="ERS852478_02339"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="12"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO28045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="170" mass="17821" checksum="11B96D9A502A21AA" modified="2016-09-07" version="1">MASEKEASEESALEETVVGLLKKKKMTLSLAESCTGGAVAADIVNVPGASEVFMCGYVTYTNRAKRKCLGVKKSTLKKEGAVSAKCAGQMAKGGAKAAKTDVCLSVTGLAGPGGGTEETPVGTVFMGCYCAGKTTVREFHFEGDRKSIRDQAVAQALTFICDRVCKYNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E068</accession>
    <name>A0A174E068_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">S-ribosylhomocysteine lyase</fullName>
            <ecNumber evidence="4 14">4.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">AI-2 synthesis protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 14">Autoinducer-2 production protein LuxS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">luxS</name>
        <name evidence="16" type="ORF">BWLFYP14_00096</name>
        <name evidence="15" type="ORF">ERS852478_02440</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:17753"/>
            <dbReference type="ChEBI" id="CHEBI:29484"/>
            <dbReference type="ChEBI" id="CHEBI:58195"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.4.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="14">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the LuxS family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.21" evidence="4 14"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO31191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704822.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO31191">
        <property type="protein sequence ID" value="CUO31191"/>
        <property type="gene ID" value="ERS852478_02440"/>
    </dbReference>
    <dbReference type="GeneID" id="66494326"/>
    <dbReference type="eggNOG" id="COG1854">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043768">
        <property type="term" value="F:S-ribosylhomocysteine lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009372">
        <property type="term" value="P:quorum sensing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00091">
        <property type="entry name" value="LuxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037005">
        <property type="entry name" value="LuxS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003815">
        <property type="entry name" value="S-ribosylhomocysteinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35799">
        <property type="entry name" value="PTHR35799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02664">
        <property type="entry name" value="LuxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006160">
        <property type="entry name" value="AI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01487">
        <property type="entry name" value="LUXSPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0071">Autoinducer synthesis</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0673">Quorum sensing</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO31191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VUX66543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="159" mass="18136" checksum="CC923F17D6E13998" modified="2016-09-07" version="1">MEKITSFTIDHIKLQPGIYVSRKDPVGGSMITTFDIRMTSPNEEPVMNTAELHTIEHLAATFLRNHKEFGSKMIYWGPMGCRTGNYLLLNGDYESKDIVPLMIETFEFIRDFEGEVPGASAKDCGNYLDMNLPMAKYLAGKFLDEVLYDIKPDRLIYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E798</accession>
    <name>A0A174E798_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fluoroquinolones export ATP-binding protein Rv2688c/MT2762</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Fluoroquinolones export ATP-binding protein/MT2762</fullName>
            <ecNumber evidence="5 6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_02154</name>
        <name evidence="5" type="ORF">ERS852478_02466</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5 6"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32428">
        <property type="protein sequence ID" value="CUO32428"/>
        <property type="gene ID" value="ERS852478_02466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="29"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO32428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="238" mass="26433" checksum="5E108209F94353BE" modified="2016-09-07" version="1">MEDWKKSEGTFNLACDLERASGMMQNTCVKIEHVTKRFGEDMVLQEVNLSLKTGNVYGIVGNNGSGKTVLMKCICGFLPVTTGTIFVFGKKIGHDVDFPESLGVIIETPGFLTQYTGFKNLEILADMNGRISKADIRIVLKRVGLNPDMKKPVGKYSLGMRQRLGIAQAIMEDPLFLILDEPFNGLDKHGVEEIRELLLDLKAAGKTILLASHNEEDIRILCDHVYEMDGGILRERTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EFK4</accession>
    <name>A0A174EFK4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Relaxase/Mobilisation nuclease domain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Relaxase/mobilization nuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02553</name>
        <name evidence="3" type="ORF">GT728_02290</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994028.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35229">
        <property type="protein sequence ID" value="CUO35229"/>
        <property type="gene ID" value="ERS852478_02553"/>
    </dbReference>
    <dbReference type="GeneID" id="66495297"/>
    <dbReference type="eggNOG" id="COG3843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005094">
        <property type="entry name" value="Endonuclease_MobA/VirD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03432">
        <property type="entry name" value="Relaxase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="399"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO35229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="459" mass="53389" checksum="9E782BE862ED201C" modified="2016-09-07" version="1">MAVTKIHGIKTTVDKAIEYICNPDKTDQNLYISSFACSPETAALDFKYTLDHTHDCRDPHNTNKAFHLIQAFSPGEVSYEEAHQIGRELADRLLEGKYSYVLTTHTDKGHVHNHLIFCSADNITFSHYHDCKKNYWKIRNLSDTLCQEHNLSTIMPNGKKGMKYNEWAANKSESSKKTQLRKDINQTIRIVSTYSEFLTFMEAKGYEIKNAEFGENSRKYITFRSPDMSRPVRGSAKSLGKNFTKERIKERINNKLHRTTVPSVRNKLIDTNTPNIAGNIGLQKWANKENLKIVSAEYNKMLTHNLHNFSELEDRIALLHMQQKEVNTSVVSLESQIRHLREMLKYAKQYQKNKIYDDHYKSSKDPDRYFRKYESQIILFAGAEHILQENGMDLKHLNTNKLQEQLSDLISQKKSLNTQYVSFKQEIKELELIHQNLSKYLKQDAPEIQRSSHNKLPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EFN5</accession>
    <name>A0A174EFN5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alkaline phosphatase synthesis transcriptional regulatory protein phoP</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phoP_1</name>
        <name evidence="6" type="ORF">ERS852478_02554</name>
        <name evidence="7" type="ORF">GT712_18455</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000061">
        <property type="protein sequence ID" value="MZS90973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580539.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35259">
        <property type="protein sequence ID" value="CUO35259"/>
        <property type="gene ID" value="ERS852478_02554"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="33"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO35259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS90973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="137" mass="15993" checksum="7AACA9AF0EE4DBAD" modified="2016-09-07" version="1">MKKIEIIERITDANGSISENILTSWEHKNQFIPEIIRFGELKIYLQEQIVKKNDSDVHLSKYEYDILLLLAKSPGRIFGKEMVYDLVWNEPYSGDYNVVMRHICNIREKIEDDPGQPLYIQTVRGVGYRFNGNLGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EG18</accession>
    <name>A0A174EG18_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO34890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34890">
        <property type="protein sequence ID" value="CUO34890"/>
        <property type="gene ID" value="ERS852478_02541"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO34890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="98" mass="11972" checksum="2440AD33C2A38A70" modified="2016-09-07" version="1">MNDIFKDMQAKVGCEYISDLPSYKRKVWQEMKRLNPADYEERQLEDFSKYVFGMSYQTLKDVMKQQRGREEQCRKQGCWWKRKEQLAKKQYHTGSTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EKU1</accession>
    <name>A0A174EKU1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate synthase [NADPH] small chain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">NADPH-dependent glutamate synthase</fullName>
            <ecNumber evidence="2 3">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gltD_2</name>
        <name evidence="3" type="synonym">gltA</name>
        <name evidence="2" type="ORF">ERS852478_02608</name>
        <name evidence="4" type="ORF">GT712_07410</name>
        <name evidence="3" type="ORF">GT728_02780</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.4.1.13" evidence="2 3"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000011">
        <property type="protein sequence ID" value="MZS88898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379996.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36815">
        <property type="protein sequence ID" value="CUO36815"/>
        <property type="gene ID" value="ERS852478_02608"/>
    </dbReference>
    <dbReference type="GeneID" id="66494106"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006004">
        <property type="entry name" value="Glut_synth_NADPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01316">
        <property type="entry name" value="gltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO36815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="464" mass="49585" checksum="832FFDFBA0CF6BAF" modified="2016-09-07" version="1">MADAKMLKKVPVREQDPKVRATNFEEVCLGYNQEEAMEEAQRCLGCKKPKCVEGCPVSINIPGFIEEIKEGKIEEAYKVIGLSSALPAICGRVCPQESQCEGKCIRGVKGEAVSIGKLERFVADYALEHDIKPVGAEVKNGHKVAVIGSGPSGLTCAGDLAKAGYDVTVFEALHELGGVLVYGIPEFRLPKQKVVKKEIEKVKELGVKFETNVVIGKSTTIDQLIEDEGFEAVFIGSGAGLPMFMGIPGENASGVFSANEYLTRSNLMKAFDDSYDTPIAAGKKVAVVGGGNVAMDAARTALRLGAEVHIVYRRSEAELPARAEEVHHAKEEGIIFDLLTNPKEILVDENGHVKGMKVVKMELGEPDASGRRRPVEIPGSEYDMDVDTVIMSLGTSPNPLISSTTKGLEVNKRRCIIAEEETGKTSKDGVYAGGDAVTGAATVILAMGAGKAGAKGIDEYLKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EL14</accession>
    <name>A0A174EL14_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phospho-sugar mutase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Phosphoglucomutase</fullName>
            <ecNumber evidence="11">5.4.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pgcA_1</name>
        <name evidence="14" type="ORF">BWLFYP14_00895</name>
        <name evidence="11" type="ORF">ERS852478_02632</name>
        <name evidence="13" type="ORF">GT712_05120</name>
        <name evidence="12" type="ORF">GT728_06775</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 18">BIOML-A1</strain>
            <strain evidence="13 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO37927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000012">
        <property type="protein sequence ID" value="MZL32913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000007">
        <property type="protein sequence ID" value="MZS88484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707777.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37927">
        <property type="protein sequence ID" value="CUO37927"/>
        <property type="gene ID" value="ERS852478_02632"/>
    </dbReference>
    <dbReference type="GeneID" id="66492721"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="41"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="220"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="321"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="481"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO37927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL32913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS88484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX63417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="560" mass="61240" checksum="7D6EDC47C671AF44" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EMD3</accession>
    <name>A0A174EMD3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">malP_2</name>
        <name evidence="11" type="ORF">ERS852478_02625</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO37756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026650155.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37756">
        <property type="protein sequence ID" value="CUO37756"/>
        <property type="gene ID" value="ERS852478_02625"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO37756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="820" mass="94313" checksum="822D62C94822264B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EN37</accession>
    <name>A0A174EN37_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oligopeptide-binding protein AppA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">appA</name>
        <name evidence="4" type="ORF">BWLFYP14_00900</name>
        <name evidence="3" type="ORF">ERS852478_02637</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707786.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38058">
        <property type="protein sequence ID" value="CUO38058"/>
        <property type="gene ID" value="ERS852478_02637"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252730" evidence="1">
        <location>
            <begin position="29"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="70"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO38058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX63422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="513" mass="56953" checksum="F541FC1C13ECE8B0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EP28</accession>
    <name>A0A174EP28_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="5">OTCase</shortName>
            <ecNumber evidence="3 5">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argF</name>
        <name evidence="12" type="synonym">argF_1</name>
        <name evidence="12" type="ORF">BWLFYP14_00906</name>
        <name evidence="9" type="ORF">ERS852478_02643</name>
        <name evidence="10" type="ORF">ERS852523_02306</name>
        <name evidence="11" type="ORF">GT728_06985</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">2789STDY5834863</strain>
            <strain evidence="10 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 16">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3 5"/>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000023">
        <property type="protein sequence ID" value="CUP64372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000012">
        <property type="protein sequence ID" value="MZL32950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707793.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000055_gene1902"/>
    <dbReference type="EnsemblBacteria" id="CUO38239">
        <property type="protein sequence ID" value="CUO38239"/>
        <property type="gene ID" value="ERS852478_02643"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP64372">
        <property type="protein sequence ID" value="CUP64372"/>
        <property type="gene ID" value="ERS852523_02306"/>
    </dbReference>
    <dbReference type="GeneID" id="66492694"/>
    <dbReference type="eggNOG" id="COG0078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="152"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="55"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="270"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO38239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP64372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL32950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX63428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="333" mass="37530" checksum="70AB93250F24A207" modified="2016-09-07" version="1">MNLKGRNFLTLKDFTPEEITYLIDLSAELKAKKKAGELHEYYRGKNIALIFEKTSTRTRCSFEVAAHDLGMGSTYLDPTGSQIGKKESIADTARVLGRMYDGIEYRGFGQEVVEELAKHAGVPVWNGLTNEYHPTQMIADMLTIREHFGDLKGRKLVYMGDARYNMGNSLMIACTKLGMHFVACTTKKYFPNAELVAQCEEYAKASGGSITLTEDVQEGTKDADVIYTDVWVSMGEPDEVWTERIHDLTPYKVTKDVMKNAGEKAIFLHCLPAFHDLKTKIGKEMGERFNLTDMEVTDEVFESEQSKVFDEAENRMHTIKAVMVATLGEPENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EVF8</accession>
    <name>A0A174EVF8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coat protein 40 kDa component 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cotS</name>
        <name evidence="2" type="ORF">ERS852478_02710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40536">
        <property type="protein sequence ID" value="CUO40536"/>
        <property type="gene ID" value="ERS852478_02710"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="37"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO40536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="332" mass="40292" checksum="4C1BECAD26895D8C" modified="2016-09-07" version="1">MSLYDYGLGTLAQYELTADRSARTRGALLCYTAQGLLILREFHGSEKKLEKQQELLMKLQENGINTDYFLRNNQESLVSKDKTEQRFTLQHWYEGKECDTKSREDILKSVRTLARLHILMKMEPVEEYRERSLREEYLRHNQELRKIRKFIRNKGASNVFEKNYLASVEQFLERAQYAVKLLDETDYDDLRERAWREGQVCHGEYNQHNILMLKGDHFGTAVTNFGHWSFDIQIADLYRFMRKILEKYNWNLELAGEMLREYHKIRPISAEEWKNLRVRFTYPEKYWKLANYYYSHKKVWISEKNVEKLQNLIRQREIWENFAEECFRDYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EWB2</accession>
    <name>A0A174EWB2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MTH538 TIR-like domain (DUF1863)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379857.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42402">
        <property type="protein sequence ID" value="CUO42402"/>
        <property type="gene ID" value="ERS852478_02765"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036490">
        <property type="entry name" value="MTH538_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015032">
        <property type="entry name" value="MTH538_TIR-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08937">
        <property type="entry name" value="DUF1863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52206">
        <property type="entry name" value="SSF52206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1863" evidence="1">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO42402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="166" mass="19250" checksum="11CD86411B139042" modified="2016-09-07" version="1">MAKRQVFFSFEYNKDAWRASQVRNMGKVDNSSTFSDNDWEEVKEKTDAKIREWIDNQMAKRSCLVVLIGATTSGRKWINYEIEKAYELNKGIVGIYIHGLKDKNGNQTTKGSNPFYNILIGKNKERLSKYVECYESFHLTSTYVYDDIKNNIEQLIEDAISNAGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F1G7</accession>
    <name>A0A174F1G7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Melibiose operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">melR_3</name>
        <name evidence="5" type="ORF">ERS852478_02803</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058636.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43397">
        <property type="protein sequence ID" value="CUO43397"/>
        <property type="gene ID" value="ERS852478_02803"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="195"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO43397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="299" mass="35482" checksum="4D030F38C6EC2902" modified="2016-09-07" version="1">MAEIITDGSQKELKKHGSDEFPLLVSYEKLSGYKSGSFLWHWHPEIEITLVLDGQILYKVNQCTYHMKAGDILLGNANVLHAGFMEDMKDGKYVSITFLPKIIYGSYGSILRRKYVEPFLHNFSLPAVYIDYSQPWHEVFSEYVREIITLYEEKKEFYELDITGTLQKLWRCMLQNLPENLPYTEHSKLERNRMREIMDYLEHNYMNKIQMKDIAEEIHLCESECSRLFKRYMNVSLFTFLQEYRVERSLEFLLSSDDSIMEVAQKSGFTDSNYYAKVFSRVKGCSPQKYRKQNIREDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FQC5</accession>
    <name>A0A174FQC5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_00780</name>
        <name evidence="1" type="ORF">ERS852478_03061</name>
        <name evidence="3" type="ORF">GT712_15115</name>
        <name evidence="2" type="ORF">GT728_15280</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">BIOML-A1</strain>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000043">
        <property type="protein sequence ID" value="MZL34518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000035">
        <property type="protein sequence ID" value="MZS90362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000020">
        <property type="protein sequence ID" value="VUX63095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707729.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51921">
        <property type="protein sequence ID" value="CUO51921"/>
        <property type="gene ID" value="ERS852478_03061"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033W5Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO51921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL34518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX63095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="91" mass="10559" checksum="1C014BC792FFC893" modified="2016-09-07" version="1">MMNKKSKNKKLRRKLSFVLFVAAVGVLMMRAMPGMSGKIAKIAERRQEQTAVTAWWGTLYPKFCFSQFPEENKGQKDDIKISFWLAQALDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FV23</accession>
    <name>A0A174FV23_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO52449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201120.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52449">
        <property type="protein sequence ID" value="CUO52449"/>
        <property type="gene ID" value="ERS852478_03082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022000" evidence="1">
        <location>
            <begin position="35"/>
            <end position="1299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO52449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1299" mass="137908" checksum="0BC4748680E854B7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FXF9</accession>
    <name>A0A174FXF9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH deoR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_03132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO54117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579836.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54117">
        <property type="protein sequence ID" value="CUO54117"/>
        <property type="gene ID" value="ERS852478_03132"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO54117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="113" mass="12344" checksum="A86938C29D13B2D8" modified="2016-09-07" version="1">MNFEFMTIDTPLPPCMPFPRALTGFPVSSTAKVMYCRMLDAMLSKGQEDENGILFVCFPVTAIAAVLSRSPMTVKRSLNELETAGLIMRVCQGVGEPNRIYVLIPGKEDAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FZ99</accession>
    <name>A0A174FZ99_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380866.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55544">
        <property type="protein sequence ID" value="CUO55544"/>
        <property type="gene ID" value="ERS852478_03176"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2954">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023577">
        <property type="entry name" value="CYTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012042">
        <property type="entry name" value="NeuTTM/CthTTM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40114">
        <property type="entry name" value="PTHR40114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01928">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016487">
        <property type="entry name" value="CYTH_UCP016487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01118">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="SSF55154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51707">
        <property type="entry name" value="CYTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO55544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="151" mass="17626" checksum="8C901B3FBE874BBE" modified="2016-09-07" version="1">MEIERKFLISKENLPADLDAYPHHKLEQGYLSTAPVVRIRKEDDNYYLTYKSKGLMTREEYNLPLTKESYEHMRPKADGILISKTRYLIPEKDRLTIELDVFDAPYEGLYLAEVEFSSEEQALSYNPPVWFGKDVTNSGKYHNSRLSQGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G0J3</accession>
    <name>A0A174G0J3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ppdK</name>
        <name evidence="14" type="ORF">ERS852478_03182</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201217.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56072">
        <property type="protein sequence ID" value="CUO56072"/>
        <property type="gene ID" value="ERS852478_03182"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="17"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="303"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="421"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="518"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="831"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="745"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="766"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="768"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO56072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="876" mass="96351" checksum="34FF9D8C72DD64FA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G268</accession>
    <name>A0A174G268_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Energy-coupling factor transporter transmembrane protein EcfT</fullName>
            <shortName evidence="9">ECF transporter T component EcfT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ecfT_2</name>
        <name evidence="9" type="synonym">ecfT</name>
        <name evidence="14" type="synonym">ecfT_1</name>
        <name evidence="11" type="synonym">ecfT_5</name>
        <name evidence="14" type="ORF">BWLFYP14_00868</name>
        <name evidence="10" type="ORF">ERS852478_03166</name>
        <name evidence="11" type="ORF">ERS852523_03515</name>
        <name evidence="13" type="ORF">GT712_16105</name>
        <name evidence="12" type="ORF">GT728_16520</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">2789STDY5834863</strain>
            <strain evidence="11 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 19">BIOML-A1</strain>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cell membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the energy-coupling factor EcfT family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000053">
        <property type="protein sequence ID" value="CUP98625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000051">
        <property type="protein sequence ID" value="MZL34754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000041">
        <property type="protein sequence ID" value="MZS90541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000024">
        <property type="protein sequence ID" value="VUX63390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705979.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000094_gene764"/>
    <dbReference type="EnsemblBacteria" id="CUO55216">
        <property type="protein sequence ID" value="CUO55216"/>
        <property type="gene ID" value="ERS852478_03166"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP98625">
        <property type="protein sequence ID" value="CUP98625"/>
        <property type="gene ID" value="ERS852523_03515"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01461">
        <property type="entry name" value="EcfT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024919">
        <property type="entry name" value="EcfT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO55216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP98625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL34754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS90541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX63390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="267" mass="30224" checksum="31BFED87C7FC2F04" modified="2016-09-07" version="1">MIRDITIGQYYPADSVLHKMDPRAKLVGTLVFIISVFVFHTFPGYAVATIFLAAMIILSKVPVKFMFKGLKAIVMLLMITVVFNIFLTPGKVLWQWGILHVTEEGLKLAGRMAIRLTYLVIGSSLMTLTTTPNQLTDGLERLLRPLNKLHVPIHEIAMMMSIALRFIPILMEETDKIMKAQIARGADFETGNIIQKAKNMIPLLVPLFISAFRRANDLAMAMEARCYHGGDNRTQMKPLRYESRDYISYVVMWAYLGIAIVFRIVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G8L7</accession>
    <name>A0A174G8L7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_03485</name>
        <name evidence="1" type="ORF">ERS852478_03268</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO58774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58774">
        <property type="protein sequence ID" value="CUO58774"/>
        <property type="gene ID" value="ERS852478_03268"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO58774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX67210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="37" mass="4146" checksum="192A178BEC657FF1" modified="2016-09-07" version="1">MKRYFGIFNADEIKSGSCSDIQWKKTGLLKIPKDAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G9S0</accession>
    <name>A0A174G9S0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">trpB</name>
        <name evidence="13" type="ORF">ERS852478_03228</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381374.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57609">
        <property type="protein sequence ID" value="CUO57609"/>
        <property type="gene ID" value="ERS852478_03228"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="50"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO57609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="394" mass="43069" checksum="8D3A366349A87D5A" modified="2016-09-07" version="1">MSKGRFGIHGGQYIPETLMNAVIELEEAYNHYKDDPEFNAELTELLNEYAGRPSRLYFASHMTEDLGGAKVYLKREDLNHTGAHKINNVLGQVLLAKKMGKTRVIAETGAGQHGVATATAAALMGMECEIFMGKEDTERQALNVYRMRLLGAKVNAVTSGTATLKDAVSETMREWTNRISDTHYVLGSVMGPHPFPTIVRDFQAVISKEIKEQILEKEGRLPDAVLACVGGGSNAIGTFYNFINDKDVRLIGCEAAGRGVNTAETAATIATGKLGIFHGMKSYFCQDEYGQIAPVYSISAGLDYPGIGPEHAHLYDTGRAEYVPVTDEEAVEAFEYLSRTEGIIPAIESAHAVAYARKIVPQMRKDQIVVITISGRGDKDCAAIARYRGEDIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GDY8</accession>
    <name>A0A174GDY8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HicB family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Toxin-antitoxin system HicB family antitoxin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein encoded in hypervariable junctions of pilus gene clusters</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_00741</name>
        <name evidence="2" type="ORF">ERS852478_03325</name>
        <name evidence="3" type="ORF">ERS852523_03779</name>
        <name evidence="5" type="ORF">GT712_14970</name>
        <name evidence="4" type="ORF">GT728_14585</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000064">
        <property type="protein sequence ID" value="CUQ05397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000039">
        <property type="protein sequence ID" value="MZL34390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000034">
        <property type="protein sequence ID" value="MZS90335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000019">
        <property type="protein sequence ID" value="VUX62992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704906.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000041_gene2594"/>
    <dbReference type="EnsemblBacteria" id="CUO60744">
        <property type="protein sequence ID" value="CUO60744"/>
        <property type="gene ID" value="ERS852478_03325"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ05397">
        <property type="protein sequence ID" value="CUQ05397"/>
        <property type="gene ID" value="ERS852523_03779"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031807">
        <property type="entry name" value="HicB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15919">
        <property type="entry name" value="HicB_lk_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HicB-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO60744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ05397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX62992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="120" mass="13555" checksum="55670216F9FC9D6F" modified="2016-09-07" version="1">MKTLNDYMSMSYRMEVVEDKTEGGFVVSYPDLPGCITCGETVESAISNALDAKKAWLEAALEEGVEIHEPDSLEDYSGQFKLRIPRSLHRLLAEHSQREGISMNQYCVYLLSRNDAVFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GDZ0</accession>
    <name>A0A174GDZ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
            <ecNumber evidence="3">2.1.1.79</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cfa</name>
        <name evidence="3" type="ORF">ERS852478_03282</name>
        <name evidence="5" type="ORF">GT712_01220</name>
        <name evidence="4" type="ORF">GT728_13065</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A1</strain>
            <strain evidence="5 7">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.79" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO59130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000032">
        <property type="protein sequence ID" value="MZL34105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705100.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59130">
        <property type="protein sequence ID" value="CUO59130"/>
        <property type="gene ID" value="ERS852478_03282"/>
    </dbReference>
    <dbReference type="GeneID" id="66495407"/>
    <dbReference type="eggNOG" id="COG2230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008825">
        <property type="term" value="F:cyclopropane-fatty-acyl-phospholipid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO59130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS87743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="394" mass="46017" checksum="60D7A858EA5DDB16" modified="2016-09-07" version="1">MFETLGEKAEEKAMVQFLERFTDYPFLVKFKNSEYPIGEGEPTFTVNFKETIPLAELLKSTSLALGEAYMRGDLDIEGNLYEALDHFLGQMSKFSTNESALKKIMFSSTSKKNQEKEVTSHYDIGNDFYKLWLDETMSYSCGYFIHDDDSLYQAQVNKVDYILKKLHLEEGMSLLDIGCGWGFLLIEAAKKYKVHGTGITLSHEQYTEFQKRIKDQGLEDYLTVELMDYRDLPKHNYQFDRVVSVGMLEHVGRDNYQLFLDCVEKVLKPGGLFLLHFISALKEHPGDPWIKKYIFPGGTVPSLREILNHMAEDNFHTLDIENLRLHYNKTLLHWEKNFRENIEKEKTMFDESFLRMWELYLSACAATFHNGIIDLHQILMTKGINNDLPMTRWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GFM9</accession>
    <name>A0A174GFM9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Ferredoxin-dependent glutamate synthase 1</fullName>
            <ecNumber evidence="17">1.4.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">gltB</name>
        <name evidence="17" type="ORF">ERS852478_03316</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.7.1" evidence="17"/>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201277.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60367">
        <property type="protein sequence ID" value="CUO60367"/>
        <property type="gene ID" value="ERS852478_03316"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016041">
        <property type="term" value="F:glutamate synthase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="16">
        <location>
            <begin position="23"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="897"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="902"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUO60367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1517" mass="168241" checksum="FE74215F6F46EE40" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GFX6</accession>
    <name>A0A174GFX6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_00748</name>
        <name evidence="3" type="ORF">ERS852478_03318</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000019">
        <property type="protein sequence ID" value="VUX62999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60457">
        <property type="protein sequence ID" value="CUO60457"/>
        <property type="gene ID" value="ERS852478_03318"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO60457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX62999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="81" mass="9711" checksum="B8AAA3F3E47A7BFC" modified="2016-09-07" version="1">MLALTAADFNFEKETVRINKFYQRLHGEDVITTPKTKKSNRMIKMPKFLCEEMQEYLQMLYGLKKKDRIFTVTKNIVEVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GKP5</accession>
    <name>A0A174GKP5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03334</name>
        <name evidence="4" type="ORF">GT712_15015</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO61015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000034">
        <property type="protein sequence ID" value="MZS90343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025581322.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000148.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61015">
        <property type="protein sequence ID" value="CUO61015"/>
        <property type="gene ID" value="ERS852478_03334"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="232"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO61015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="398" mass="46780" checksum="95D9A504B89F67D7" modified="2016-09-07" version="1">MKTITRAKYLDRIIELNGTPDIKIITGIRRSGKSKLMQAYIAYLKNNFENINIIFIDFMDLAYEEIKEYHALHSYVEEHYQEGKTNYLFVDEVQMCPKFELAINSLYSKGKYDIYVTGSNAFLLSADLATLFTGRYIEIHMFPFSFQEYCQYYDDISDKDKLFDEYSIKGGLAGSYAYRTEKDRTNYIKEVYETIVTRDLVQKYNLPDTLVLQRLSEFLMDNISNLTSPNKISQLLTANETPTNHVTVGKYIKYLCNAFVFYDIKRYDIRGKKYLESSEKFYLCDSGIRYAILGSRNMDYGRVYENIVCIELLRRGYDVYVGKLYQKEIDFVAQRGSEKFYIQVSDNISGQETFERECSPLLQIRDAYPKMIIARTKHPQYSYEGIQIHDIADWLLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GTJ2</accession>
    <name>A0A174GTJ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_02360</name>
        <name evidence="1" type="ORF">ERS852478_03490</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708178.1">
        <property type="nucleotide sequence ID" value="NZ_WWVC01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65934">
        <property type="protein sequence ID" value="CUO65934"/>
        <property type="gene ID" value="ERS852478_03490"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO65934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX65990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="98" mass="11604" checksum="68CF9F038C0CCF94" modified="2016-09-07" version="1">MKQALVEDENSIKKYFEMYAKADFDDEDTRNQVLEYFVDKIYVYNDRLVITWYYSDDKTSIDLDALTEITETSESNTVDRVSTLLQSDPYTFLPYVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GXV6</accession>
    <name>A0A174GXV6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67454">
        <property type="protein sequence ID" value="CUO67454"/>
        <property type="gene ID" value="ERS852478_03538"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030YPM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO67454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="33" mass="4134" checksum="24EA00B2C5F3768E" modified="2016-09-07" version="1">MQQNIEFERCIDFLVRMIDKYGEEVLRELEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H490</accession>
    <name>A0A174H490_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201438.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68227">
        <property type="protein sequence ID" value="CUO68227"/>
        <property type="gene ID" value="ERS852478_03564"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO68227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="93" mass="10808" checksum="861C2A13BF58FD09" modified="2016-09-07" version="1">METWKNRDMIYDVVIGAVEEGNANPEVKTVFGEDSLCEKLYEKIYQTKEKLSQRLGKEGEEDADIEKIINNMFDICRIVGNKMYEYGKMDTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H5B7</accession>
    <name>A0A174H5B7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Group II intron-encoded protein ltrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ltrA_4</name>
        <name evidence="3" type="ORF">ERS852478_03627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO70103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201469.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70103">
        <property type="protein sequence ID" value="CUO70103"/>
        <property type="gene ID" value="ERS852478_03627"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030931">
        <property type="entry name" value="Group_II_RT_mat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04416">
        <property type="entry name" value="group_II_RT_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="66"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO70103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="431" mass="51148" checksum="F94552C61A8A3782" modified="2016-09-07" version="1">METKLVRIAEISATSKHPIFTSVYHLINEDMLKQCHKELDGNKAVGIDKVTKDEYGKNLDRNIKELVQRLKNKSFKPLPSLRVYIPKGNGKKRPLGIASYEDKIVQMAVKKILGAIYEPRFLNCMYGFRPNRGCHEAIKEVYQRISYGKISYIVDADIKGFFDHIDHDWMMKFLEWNIQDKNLLWLIRKYLKAGIMEQGKFEPTEEGSAQGSVMSPMLANIYMHHVLTLWFKLVVQREMQGECFLVNFADDFVAGFQYKSEAERYYKELKERMEKFGLELESSKSRLIEFGRFAEQNRRARGECKPETFGFLGFTFYCSKTRKGGFVPKVQTSRKKFELKVRAYKNWIYDNRNRPMREIIKELNVKLIGHYRYYGVTWNFRKITTFLHRVQQFLFKAMNRRGCRRAYTWNGFVEMLKYYPLAKPKTHYCLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HSQ0</accession>
    <name>A0A174HSQ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CysJI operon transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cysL_4</name>
        <name evidence="3" type="ORF">ERS852478_03822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000054">
        <property type="protein sequence ID" value="CUO76100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201543.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000054.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76100">
        <property type="protein sequence ID" value="CUO76100"/>
        <property type="gene ID" value="ERS852478_03822"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO76100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="298" mass="33842" checksum="E7B8AEED2F89CD4E" modified="2016-09-07" version="1">MEFKQLEAFVAVVDYGSFSEAARRLYLTQPTISAHIRSLEDELHMKLIIRTTKKTTITAKGYQLYDSAVRMLEIRNNLLENFTGAHKHMIDLAASTIPSSYLLPELLAAFGKTHPDVYFHSIQSDSSESISRVLDGTVDLALVGQNTRDESCVFIPFCHDELVIATPVTDHYLALKDRETPAIFHDFLKDPIILREKGSGTKKEMDLFLERTGITTGNLNVIARMNDLESIKKSIVNGLGISILSSRSVNDLQKTKQILVFPLEEAAHKRSFYIVYSKNRILKPHVKQFVQFVRDYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JDG3</accession>
    <name>A0A174JDG3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">50S ribosomal protein L7ae</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Putative ribosomal protein YlxQ</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ribosomal protein L30E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplGA</name>
        <name evidence="6" type="ORF">BWLFYP14_00444</name>
        <name evidence="2" type="ORF">ERS852478_02024</name>
        <name evidence="3" type="ORF">ERS852523_00057</name>
        <name evidence="5" type="ORF">GT712_10185</name>
        <name evidence="4" type="ORF">GT728_08810</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO95658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000018">
        <property type="protein sequence ID" value="MZS89426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993678.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2223"/>
    <dbReference type="EnsemblBacteria" id="CUO16546">
        <property type="protein sequence ID" value="CUO16546"/>
        <property type="gene ID" value="ERS852478_02024"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95658">
        <property type="protein sequence ID" value="CUO95658"/>
        <property type="gene ID" value="ERS852523_00057"/>
    </dbReference>
    <dbReference type="GeneID" id="66495644"/>
    <dbReference type="eggNOG" id="COG1358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="1">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO16546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO95658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX62370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="99" mass="10979" checksum="CAEF90C2DBACF20A" modified="2016-09-07" version="1">MKNNRVLSLIGLATKAGKTVSGEFSTEKSVKTGKGLLVIVAEDASENTKKKFRNMCSFYEVPIFFFSDKESLGRAMGKEYRACLAVQDENFAKAIMKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KUX7</accession>
    <name>A0A174KUX7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trp repressor protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">TrpR YerC/YecD</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01824</name>
        <name evidence="1" type="ORF">ERS852478_00677</name>
        <name evidence="2" type="ORF">ERS852523_00667</name>
        <name evidence="4" type="ORF">GT712_03305</name>
        <name evidence="3" type="ORF">GT728_03655</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP13618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706557.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000015_gene3729"/>
    <dbReference type="EnsemblBacteria" id="CUN64276">
        <property type="protein sequence ID" value="CUN64276"/>
        <property type="gene ID" value="ERS852478_00677"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13618">
        <property type="protein sequence ID" value="CUP13618"/>
        <property type="gene ID" value="ERS852523_00667"/>
    </dbReference>
    <dbReference type="GeneID" id="66493454"/>
    <dbReference type="eggNOG" id="COG4496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000831">
        <property type="entry name" value="Trp_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038116">
        <property type="entry name" value="TrpR-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013368">
        <property type="entry name" value="YecD_YerC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40080">
        <property type="entry name" value="PTHR40080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01371">
        <property type="entry name" value="Trp_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012508">
        <property type="entry name" value="YerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02531">
        <property type="entry name" value="yecD_yerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN64276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP13618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="101" mass="11655" checksum="7023F8D29377E0E0" modified="2016-09-07" version="1">MSKKIRTEAVDQLFEAILCLKDKEECYTFFEDVCTINELLSLSQRFEVAKMLMDKRTYLDISEKTGASTATISRVNRSLNYGNDGYEMVFSRMAEKETKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L1I5</accession>
    <name>A0A174L1I5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GTP pyrophosphokinase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">GTP pyrophosphokinase yjbM</fullName>
            <ecNumber evidence="5">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yjbM</name>
        <name evidence="4" type="ORF">ERS852478_00009</name>
        <name evidence="5" type="ORF">ERS852523_00760</name>
        <name evidence="7" type="ORF">GT712_07855</name>
        <name evidence="6" type="ORF">GT728_12675</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">2789STDY5834863</strain>
            <strain evidence="5 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">BIOML-A1</strain>
            <strain evidence="7 10">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN40884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP16691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000031">
        <property type="protein sequence ID" value="MZL34031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025576989.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1373"/>
    <dbReference type="EnsemblBacteria" id="CUN40884">
        <property type="protein sequence ID" value="CUN40884"/>
        <property type="gene ID" value="ERS852478_00009"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP16691">
        <property type="protein sequence ID" value="CUP16691"/>
        <property type="gene ID" value="ERS852523_00760"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="3">
        <location>
            <begin position="45"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN40884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP16691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL34031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS88986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="270" mass="31922" checksum="ACD64E08FEEE19D4" modified="2016-09-07" version="1">MEIQLWRSILCPYELAVRELEVKFNHIIDECKENDVYCPIEQVEGRVKSVSSILEKMQRKHIPMERMEEELEDIAGVRIICQFEEDIETVASLIQKRSDMVIKSEKNYLKHIKQSGYRSYHLIIYYTVDTIKGPKKLQAEIQIRTMAMNFWATIEHSLQYKYKGDMPEHVAERLSKAADAINALDHEMSSVRNEIMDAQNSSQMQSNLVKDILINIENLYKIANKREIMKIQDEFLRVFKTKDLQQLKRFHRQLDIISEGYRAQAVYHHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L7U7</accession>
    <name>A0A174L7U7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">phoR_1</name>
        <name evidence="10" type="synonym">phoR_2</name>
        <name evidence="12" type="synonym">phoR_6</name>
        <name evidence="12" type="ORF">BWLFYP14_01621</name>
        <name evidence="10" type="ORF">ERS852478_01279</name>
        <name evidence="11" type="ORF">ERS852523_00871</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">2789STDY5834863</strain>
            <strain evidence="11 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000007">
        <property type="protein sequence ID" value="CUP20203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705652.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000050.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000052_gene885"/>
    <dbReference type="EnsemblBacteria" id="CUN87632">
        <property type="protein sequence ID" value="CUN87632"/>
        <property type="gene ID" value="ERS852478_01279"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20203">
        <property type="protein sequence ID" value="CUP20203"/>
        <property type="gene ID" value="ERS852523_00871"/>
    </dbReference>
    <dbReference type="GeneID" id="66494962"/>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="193"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="253"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN87632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP20203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX64766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="470" mass="53422" checksum="101BFBAA0DE76EE3" modified="2016-09-07" version="1">MKQHHLSTKFLRFYILIGILGFFLITLGGSYMVEKHLEHSLSAALYTEAHNIASNEAVKSNISSSTVDTLQEHLCAISDFQDAVLWIINSNGEIIVSTQKNIDVRDPIPLEEFDASKWGSNYYQIGKFYGFFKTDHLSVIAPITSDMETKGYVAIHYSMTNLYQSRSSILFIMQVIFLLCYAATSLLLWAYSHYIRKPLARIMKGASEYAGGNLAYKIDVTSDDEMGYLAKTLNYMSDELNKNGEYQRKFIANVSHDFRSPLTSIKGYVNAILDGTIPYEMQERYLKIIAFESERLEKLTRSLLTLNELDMKKRMMHIQRFDINDTIKNTAATFEGICTSRQIRLELLLSGHELYVRADMEQIQQVLYNLLDNAIKFSNDNSSVQIETTVKSGKVFVSVKDYGTGIPKESLGKIWDRFYKIDASRGKDRKGTGLGLSIVKEIINAHNQNIDVISTEGVGTEFIFTLEKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MIF9</accession>
    <name>A0A174MIF9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">rpsJ</name>
        <name evidence="10" type="ORF">BWLFYP14_00254</name>
        <name evidence="6" type="ORF">ERS852478_01656</name>
        <name evidence="7" type="ORF">ERS852523_01296</name>
        <name evidence="9" type="ORF">GT712_08995</name>
        <name evidence="8" type="ORF">GT728_04685</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707245.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2985"/>
    <dbReference type="EnsemblBacteria" id="CUO02543">
        <property type="protein sequence ID" value="CUO02543"/>
        <property type="gene ID" value="ERS852478_01656"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33715">
        <property type="protein sequence ID" value="CUP33715"/>
        <property type="gene ID" value="ERS852523_01296"/>
    </dbReference>
    <dbReference type="GeneID" id="66496119"/>
    <dbReference type="eggNOG" id="COG0051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO02543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP33715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL32515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX67413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="105" mass="11838" checksum="4ECC84413988A019" modified="2016-09-07" version="1">MANQVMRITLKAYDHQLVDASAAKIIETVKKNGAMVSGPVPLPTKKEVVTILRAVHKYKDSREQFEQRTHKRLIDILTPTQKTVDALSRLEMPAGVNIDIKMKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NZB3</accession>
    <name>A0A174NZB3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FtsW/RodA/SpoVE family cell cycle protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Rod shape-determining protein RodA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mrdB</name>
        <name evidence="10" type="ORF">BWLFYP14_02628</name>
        <name evidence="7" type="ORF">ERS852478_00130</name>
        <name evidence="8" type="ORF">ERS852523_01860</name>
        <name evidence="9" type="ORF">GT712_00810</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
            <strain evidence="8 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP51335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703169.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000078.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000020_gene95"/>
    <dbReference type="EnsemblBacteria" id="CUN44551">
        <property type="protein sequence ID" value="CUN44551"/>
        <property type="gene ID" value="ERS852478_00130"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP51335">
        <property type="protein sequence ID" value="CUP51335"/>
        <property type="gene ID" value="ERS852523_01860"/>
    </dbReference>
    <dbReference type="GeneID" id="66495894"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN44551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP51335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS87665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX66256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="386" mass="42660" checksum="42E614057298CD5B" modified="2016-09-07" version="1">MLKQYKLRFYNFRLIIFLLAISLIGVTLVGTAASDLRSKQFAGVILGLIVMLILSLLDYSWIMNFQWIMYGFNIIMLIVVRIAGDSANGAARWIGIGSFRFQPTELSKIILIVFFAKFFMDHEETLNTLKTLALSGVLLAVPLFLILEQPDLKNTITVVVIFCIMIYIAGLSYKIIGGALLIAVPLTIIFLSIVVQPDQKLLKDYQRSRIMSFLYPENEEYSDDIEQQNNSKTAIASGELVGKKLSGDDSTTSVNQGNFVAENQTDFIFAVAGEEYGFIGCVIIVLLLLAIAFECIRMSLRAKDLSGKVLCCGIGGLIALQSFINICVATGLAPNTGTPLPFVSYGLTSLVSLYIGMGLVLNVGLQSSTYNKEIIQKEIDRREDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174PMR9</accession>
    <name>A0A174PMR9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
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                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
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        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000023_gene1783"/>
    <dbReference type="EnsemblBacteria" id="CUN72063">
        <property type="protein sequence ID" value="CUN72063"/>
        <property type="gene ID" value="ERS852478_00883"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP68976">
        <property type="protein sequence ID" value="CUP68976"/>
        <property type="gene ID" value="ERS852523_02462"/>
    </dbReference>
    <dbReference type="GeneID" id="66493009"/>
    <dbReference type="eggNOG" id="ENOG5033PTJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN72063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP68976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL31838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX64163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="177" mass="21287" checksum="29FB16E75029D371" modified="2016-09-07" version="1">MENIDFVSIYRKYRSRAFNIGKFILGDEDEAEDVCQDVFETLFHMGRSVDFSDEKKLENLIVRISYHKASDHRKKAFRKYEYANSDAILEMTDMRVRKGNRVDEIVLNLEAAGYLQSIFEKLREKNRTNYEIYVSVTLYDIPTRLVARHYHITENNVNNRVMRTRRWLAREYKKITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174RX49</accession>
    <name>A0A174RX49_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_00783</name>
        <name evidence="2" type="ORF">ERS852478_03058</name>
        <name evidence="3" type="ORF">ERS852523_03131</name>
        <name evidence="5" type="ORF">GT712_15100</name>
        <name evidence="4" type="ORF">GT728_15295</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000040">
        <property type="protein sequence ID" value="CUP88267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000043">
        <property type="protein sequence ID" value="MZL34521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000035">
        <property type="protein sequence ID" value="MZS90359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000020">
        <property type="protein sequence ID" value="VUX63101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379933.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000043.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000091_gene2603"/>
    <dbReference type="EnsemblBacteria" id="CUO51838">
        <property type="protein sequence ID" value="CUO51838"/>
        <property type="gene ID" value="ERS852478_03058"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP88267">
        <property type="protein sequence ID" value="CUP88267"/>
        <property type="gene ID" value="ERS852523_03131"/>
    </dbReference>
    <dbReference type="GeneID" id="66493348"/>
    <dbReference type="eggNOG" id="ENOG50313SJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO51838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP88267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX63101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="151" mass="16831" checksum="5A1F9472A75758E9" modified="2016-09-07" version="1">MSTVTIVLLVILVILIAALIGLYFFGKKAQKKQEEQQAQIEATKQTVSMLVIDKKRMPLKESGLPQMVIEQTPKLMRRSKLPIVKAKIGPKIAIMIADEKVFDLIPLKKEIKAEVSGLYIVGVKGIRGSLQTPAPKKKGFFAKFKKDKTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SX22</accession>
    <name>A0A174SX22_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_03372</name>
        <name evidence="1" type="ORF">ERS852478_02821</name>
        <name evidence="2" type="ORF">ERS852523_03647</name>
        <name evidence="4" type="ORF">GT712_17420</name>
        <name evidence="3" type="ORF">GT728_08565</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000058">
        <property type="protein sequence ID" value="CUQ02142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000016">
        <property type="protein sequence ID" value="MZL33247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000050">
        <property type="protein sequence ID" value="MZS90787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705184.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43921">
        <property type="protein sequence ID" value="CUO43921"/>
        <property type="gene ID" value="ERS852478_02821"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ02142">
        <property type="protein sequence ID" value="CUQ02142"/>
        <property type="gene ID" value="ERS852523_03647"/>
    </dbReference>
    <dbReference type="GeneID" id="66494706"/>
    <dbReference type="eggNOG" id="ENOG5033Z9H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO43921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUQ02142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX67095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="84" mass="9923" checksum="F89EA20016984708" modified="2016-09-07" version="1">MRLEKVQEALKTKKIHYEYTEENGCGSIDFMFRGLRFHIWEYEDRVWGAETNVFEAGRSQDIEGDYEEIISGEILSWPDMLPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174T8L4</accession>
    <name>A0A174T8L4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">recJ</name>
        <name evidence="9" type="synonym">recJ_2</name>
        <name evidence="13" type="ORF">BWLFYP14_00516</name>
        <name evidence="9" type="ORF">ERS852478_02521</name>
        <name evidence="10" type="ORF">ERS852523_03682</name>
        <name evidence="12" type="ORF">GT712_02250</name>
        <name evidence="11" type="ORF">GT728_13335</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000060">
        <property type="protein sequence ID" value="CUQ03179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000033">
        <property type="protein sequence ID" value="MZL34159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000004">
        <property type="protein sequence ID" value="VUX62643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703731.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000029_gene642"/>
    <dbReference type="EnsemblBacteria" id="CUO33800">
        <property type="protein sequence ID" value="CUO33800"/>
        <property type="gene ID" value="ERS852478_02521"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ03179">
        <property type="protein sequence ID" value="CUQ03179"/>
        <property type="gene ID" value="ERS852523_03682"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="6">
        <location>
            <begin position="77"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="7">
        <location>
            <begin position="327"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="8">
        <location>
            <begin position="460"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO33800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUQ03179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL34159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS87943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX62643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="570" mass="63874" checksum="B610DD4BC078AB57" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174UK99</accession>
    <name>A0A174UK99_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maff2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03119</name>
        <name evidence="3" type="ORF">ERS852523_04369</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000109">
        <property type="protein sequence ID" value="CUQ20438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_069432580.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000109.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000050_gene3059"/>
    <dbReference type="EnsemblBacteria" id="CUO53775">
        <property type="protein sequence ID" value="CUO53775"/>
        <property type="gene ID" value="ERS852478_03119"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ20438">
        <property type="protein sequence ID" value="CUQ20438"/>
        <property type="gene ID" value="ERS852523_04369"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032RXK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024272">
        <property type="entry name" value="MAFF-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12750">
        <property type="entry name" value="Maff2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO53775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ20438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="52" mass="5497" checksum="D890FA7EC7B96F12" modified="2016-09-07" version="1">MEFFNSAIDVLQTLVIALGAGLGIWGVINLLEGYGNDNPGAKSQGIKQFMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WWH2</accession>
    <name>A0A173WWH2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">LexA repressor</fullName>
            <ecNumber evidence="12">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lexA_1</name>
        <name evidence="12 18" type="synonym">lexA</name>
        <name evidence="20" type="synonym">lexA_2</name>
        <name evidence="20" type="ORF">BWLFYP14_02603</name>
        <name evidence="16" type="ORF">ERS852478_00105</name>
        <name evidence="17" type="ORF">ERS852523_01885</name>
        <name evidence="19" type="ORF">GT712_00940</name>
        <name evidence="18" type="ORF">GT728_02920</name>
    </gene>
    <organism evidence="16 21">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 21 22" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 21">2789STDY5834863</strain>
            <strain evidence="17 22">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="18 24 25" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 25">BIOML-A1</strain>
            <strain evidence="19 24">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="20 23" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase S24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="12"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP52005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000005">
        <property type="protein sequence ID" value="MZL32171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703132.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000020_gene121"/>
    <dbReference type="EnsemblBacteria" id="CUN43853">
        <property type="protein sequence ID" value="CUN43853"/>
        <property type="gene ID" value="ERS852478_00105"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP52005">
        <property type="protein sequence ID" value="CUP52005"/>
        <property type="gene ID" value="ERS852523_01885"/>
    </dbReference>
    <dbReference type="GeneID" id="66495920"/>
    <dbReference type="eggNOG" id="COG1974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="11 12" id="KW-0742">SOS response</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="15">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="14">
        <location>
            <begin position="86"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="12">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="12">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="12">
        <location>
            <begin position="93"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUN43853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUP52005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MZL32171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MZS87690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VUX66231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="206" mass="23068" checksum="B6F0000C461DD42B" modified="2016-09-07" version="1">MPYGRITPKQQEILDYIKNEILNRGFPPAVREICEAVNLKSTSSVHSHLEALEKNGYIRRDATKPRAIEIIDDNFNLVRREVVNVPIIGTVAAGQPLLAVENIEGYFPIPAEFMPNSQSFLLKVKGESMINAGIFDGDQVLVKQQSTAEDGDIVVALIDDGATVKTFHKEKGYYRLQPENDTMEPILVHEGLQILGKVFGVFRLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WWZ8</accession>
    <name>A0A173WWZ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="6">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase II</fullName>
            <shortName evidence="6">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">lspA</name>
        <name evidence="9" type="ORF">ERS852478_00111</name>
        <name evidence="10" type="ORF">GT728_20295</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the peptidase A8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000099">
        <property type="protein sequence ID" value="MZL35446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44011">
        <property type="protein sequence ID" value="CUN44011"/>
        <property type="gene ID" value="ERS852478_00111"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN44011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL35446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="174" mass="19824" checksum="C269F64F9B6376B9" modified="2016-09-07" version="1">MTAVSSVSSCMHWIRGCIIILLLTILDQGSKSLVLAQLKDQPDISLIPGVLQLRYLENRGMAFGLFEGKIPVFVILCLLFFGVFIYVYARIPKNRYYLPLSVTALVMVSGALGNFIDRVCRGYVVDFIYFSLIDFPVFNIADMYVVCSGILLVMLVCFRYKNDEDYDFLRIKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WZP0</accession>
    <name>A0A173WZP0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS607 family transposase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Resolvase, N terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02645</name>
        <name evidence="3" type="ORF">ERS852478_00147</name>
        <name evidence="4" type="ORF">GT712_00720</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZS87649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="VUX66273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703198.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000065.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44943">
        <property type="protein sequence ID" value="CUN44943"/>
        <property type="gene ID" value="ERS852478_00147"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:DNA strand exchange activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SR_IS607_transposase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-bd_dom_put_sf"/>
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        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
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        <property type="entry name" value="Resolv_N"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="50"/>
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            <end position="207"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN44943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS87649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="223" mass="26390" checksum="F33AA440187D48CF" modified="2016-09-07" version="1">MNTSNITNYKPKDFAELLGVSVKTLQRWDREGILKADRTPTDRRYYTYDQYLQFKGINTENDMRQVVIYTRVSTRNQKDDLQNQVAFLRQFCNAKGIIVDQCIEDYGSGLNYNRKEWNKLLDAVMEGKIKTIIITHKDRFIRFGYDWFEKFCMKFNTTIVAVNNEELSPQEELVQDIVSILHVFSCRLYGLRKYKKQIERDEEIAKELQDGNKPVRGTEDQDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X4V5</accession>
    <name>A0A173X4V5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_02713</name>
        <name evidence="1" type="ORF">ERS852478_00218</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
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    </organism>
    <reference evidence="1 3" key="1">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46859">
        <property type="protein sequence ID" value="CUN46859"/>
        <property type="gene ID" value="ERS852478_00218"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN46859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX66340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="61" mass="7093" checksum="817FCD5DFD99E516" modified="2016-09-07" version="1">MFVNTIIAAYNAQAVNPELMFVKQSDRNAAQEKTVYYTLDNVNFNESQELIKNKPLEFHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X8E5</accession>
    <name>A0A173X8E5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
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    <reference evidence="1 2" key="1">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46915">
        <property type="protein sequence ID" value="CUN46915"/>
        <property type="gene ID" value="ERS852478_00220"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN46915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="168" mass="18957" checksum="78AD7563005AFFD5" modified="2016-09-07" version="1">MNENLMGPLNDSKLLKSTLNNNNNFELDSNATSSTMVPAISTLIKNDSLLKNGTWAYLDSGKNKNRRYLFWTSVNVSNFPTGTKIPVIICRADNEYYVSESTTAERTGDKITTLYKVIADHQYNAESYQKIADKGTKYDSLQAAYDAYVEKITEDSNYSQFKDTLSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XB94</accession>
    <name>A0A173XB94_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposon Tn1000 resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tnpR_1</name>
        <name evidence="4" type="ORF">ERS852478_00256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49021">
        <property type="protein sequence ID" value="CUN49021"/>
        <property type="gene ID" value="ERS852478_00256"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="13"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="170"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="442"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN49021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="563" mass="65044" checksum="60DC3B3B707DBB44" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XP31</accession>
    <name>A0A173XP31_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable dihydroxyacetone kinase regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381333.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52188">
        <property type="protein sequence ID" value="CUN52188"/>
        <property type="gene ID" value="ERS852478_00358"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN52188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="192" mass="21816" checksum="F03ED55756326A49" modified="2016-09-07" version="1">MQNVIPDERYSVADEAILGAFFKLLKEKKPDRITVSDITKTAGIARSTFYNHYQDIPSLISAVEDKTIHDVFSMMENFQPKNDRDICSSYFLTLCRYTMENPFLSGLLSTPHGNDLFEKMLTMLHHYVTETTSNSRPDRHTKEEVSYVITCAIGSTIGVLHKWSRDNFNLAPEVIADILSEVFLSGMLPLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XSX5</accession>
    <name>A0A173XSX5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase F</fullName>
            <ecNumber evidence="6">2.1.1.178</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmF</name>
        <name evidence="6" type="ORF">ERS852478_00441</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.178" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199625.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54633">
        <property type="protein sequence ID" value="CUN54633"/>
        <property type="gene ID" value="ERS852478_00441"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027391">
        <property type="entry name" value="Nol1_Nop2_Fmu_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031340">
        <property type="entry name" value="RsmF_methylt_CI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13636">
        <property type="entry name" value="Methyltranf_PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17126">
        <property type="entry name" value="RsmF_methylt_CI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="5">
        <location>
            <begin position="27"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="114"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN54633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="467" mass="52659" checksum="13504A6A9401B20C" modified="2016-09-07" version="1">MNENTTPLHPAFLTRMKEMLGNEYPSFLSSFSAPRTYGLRINTSKITCEDFENLSPFPTRQIPWIKNGYFYDEDIRPSRCPYYQAGLYYLQEPSAMTPASRIPIEPGDRVLDLCAAPGGKATAAGAALQGQGLLVANDISTSRARALLRNLELFGIPNVFVANETPAKLTKAFPEFFDKIILDAPCSGEGMFRKEEALAKDWTPEKSMELSEIQKELILQAADMLRPGGLMLYSTCTFAPAEDEQTVSWLLENRPDMELAEMEDYEGFSHGVPEWGNKNPELIKCIRIFPHKMNGEGHFLALFRKKGQAIKESSRPHTKPDKNAFPLIEEFLNEIGLKTLCGQPFDWERVEIRGDKAYYLPPVAHNFRGITFLRNGLYLGDLKKNRFEPSQPLALAIRKNEAEAVISLSASDERITRYLKGETLNIEPEEAAHKKGWHLLCADGYPIGFGKLVNQILKNKYPAGWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y0C4</accession>
    <name>A0A173Y0C4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Xylulose kinase</fullName>
            <shortName evidence="3 5">Xylulokinase</shortName>
            <ecNumber evidence="3 5">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xylB_1</name>
        <name evidence="3 5" type="synonym">xylB</name>
        <name evidence="8" type="ORF">ERS852478_00506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199684.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57621">
        <property type="protein sequence ID" value="CUN57621"/>
        <property type="gene ID" value="ERS852478_00506"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02220">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3 5" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="FGGY_N" evidence="6">
        <location>
            <begin position="2"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="7">
        <location>
            <begin position="254"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="site" description="Important for activity" evidence="3">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN57621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="485" mass="53318" checksum="BFA0EB15C847D790" modified="2016-09-07" version="1">MYYIGIDLGTSAVKLLLMEDSGKICNIVSKEYPLFFPHPGWSEQKPEDWFAQSMEGMKELTKDIDRTKVAGIGFGGQMHGLVTLDKDDNVIRPAILWNDGRTGEETEYLNTVIGKEKLSEYTANIAFAGFTAPKILWMQKNEPENFKKVVKIMLPKDYLAYRLSGSFCTDVSDASGMLLLDVKNRCWSKEMLEICGITEEQLPKLYESWEVVGTLKPEIAKELGFSEDVKVVAGAGDNAAAAVGTGTVGDGQCNISLGTSGTVFISSKNFGVDENNALHSFCHADGSYHLMGCMLSAASCNKWWAEEILQTKDFAAEQAPIQKLGENNVFFLPYLMGERSPHNNPDARGVFFGMSMDSTRADMTQAVLEGVAFGLRDSLEVARSLGIKIERTKICGGGAKSPLWKKIIANVMNLKVDVLENEEGPSMGGAMLAAVGCGAYPDVETIGKKFAKVVDTVEPDPELVAKYEERYQKFRTLYPAMKPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y0M0</accession>
    <name>A0A173Y0M0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-dehydro-2-deoxygluconokinase</fullName>
            <ecNumber evidence="2">2.7.1.92</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">iolC_1</name>
        <name evidence="2" type="ORF">ERS852478_00469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.92" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199652.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56425">
        <property type="protein sequence ID" value="CUN56425"/>
        <property type="gene ID" value="ERS852478_00469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047590">
        <property type="term" value="F:5-dehydro-2-deoxygluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="264"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN56425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="342" mass="37420" checksum="94A0A7416D6F950D" modified="2016-09-07" version="1">MAKVVTMGEIMLRLSPPGYQRFAQASEFEINYGGAEANVAVSLAQLGHDVTYISKIPSNAIGEAAIATLKKTGVDCRYIARGGKRLGVYFLENGASVRPSNVVYDRADSSITQASAEEFDFDQIFDGVDLFHVSGITPVLSEETARLTRIALQKAKEHGVTTSFDLNYRTKLWTEDITGKQKLLSDLMSYVDICFGNTRDAAKCLGYAEKDTDFIDGDYSICVDEKHMENVRKRYGFIYLITTLRKSISASDNGWSGAVCSSSGLYQGSEYNLHIIDRVGGGDSFAAGFLHGILRHMGPERALEFALAAAAIKHTIPGDLNYISEEEVLTLMNSDGSGRVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YBC8</accession>
    <name>A0A173YBC8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EamA-like transporter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706130.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61129">
        <property type="protein sequence ID" value="CUN61129"/>
        <property type="gene ID" value="ERS852478_00615"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN61129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="112" mass="13037" checksum="A64B0A42AD22F7BD" modified="2016-09-07" version="1">MNRTFILIMLSGTFFSAVSQILLKQSANIKYENRIREYLNFRVILSYTIYMLILLLNTWCYTKVDMRYGPVIDTAAYVFVLLLSHFILKEKITKGKIMGNLIIIAGILIYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YC06</accession>
    <name>A0A173YC06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">D-alanyl-D-alanine carboxypeptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="13">D-alanyl-D-alanine carboxypeptidase dacB</fullName>
            <ecNumber evidence="13">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dacB_2</name>
        <name evidence="13" type="ORF">ERS852478_00621</name>
        <name evidence="14" type="ORF">GT728_05430</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="13"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000009">
        <property type="protein sequence ID" value="MZL32661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993492.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61349">
        <property type="protein sequence ID" value="CUN61349"/>
        <property type="gene ID" value="ERS852478_00621"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033254983" evidence="11">
        <location>
            <begin position="35"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="12">
        <location>
            <begin position="55"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="358"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN61349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZL32661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="433" mass="46407" checksum="CF12463820E9744A" modified="2016-09-07" version="1">MKKWKYLLKVVMAVGVIAMTAVQICTAAEGTAQAAVSEVTPVSISTNEISGWPAGPEITSETGVLMDADSGTLLYSKGGDEIRYPASITKIMTLLLAVENCSLKEDVVFTETGTRDISWDSGNIGMQVGEVMSMRACLYALVIRSANEVAAQIAEHVGGTEQHFVDMMNERAAQIGCTNTHFVNASGLPDPDHYSTAHDMALIMREGLKNKKFRRIIGATDYTIKPTNMNSEPRVLHTHHPMLAPESSYHYDGCIGGKTGYTSEAGNTLVTAAGKNGTTYITVTMKAADLAVASTDSTALFNYGYQNFTKAQVNGGEVSVPNGVTVDNLTVQENSQNGNTVDDYYYNDYLLGSVEVPEATPTPEPAVDALSDTSGGNTDQADQNEKADTVGEEKTSAGMPELRKILLIIGAAMLLLIIILSIALAKKEKRYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YEI6</accession>
    <name>A0A173YEI6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molybdate-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">modA</name>
        <name evidence="6" type="ORF">ERS852478_00646</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN62219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199741.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN62219">
        <property type="protein sequence ID" value="CUN62219"/>
        <property type="gene ID" value="ERS852478_00646"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016119" evidence="5">
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            <begin position="26"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
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            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="41"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
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        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>molybdate</name>
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        </ligand>
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        <location>
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        </location>
        <ligand>
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        <location>
            <position position="194"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUN62219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="299" mass="32251" checksum="A1B1FB4CAF1FD669" modified="2016-09-07" version="1">MRKKLIAAMMAGVLSAGMFSTGVFAADTDLKGEVNTFIAASLSNAMEEIQKDFNETYPDVEILYNADSSGTLQTQIEEGARCDIFFSAADKQMNALIDENLAKKDTVEDILENKVVLIKPKDGETKVTGFENITDAANIALAGDSVPVGQYSREIFDNLGITDEVNKMEINEGKNVSEVLAAVSEGSNEIGIVYATDAASVADKVDVIAEAPADALKTPVRYPVGLIEDKEASEDDTAAAEAFLEYIKSDDAMKVFEKYGFTAYKADDASETDDKDAETTEETDDTETNAETETTEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YPB4</accession>
    <name>A0A173YPB4_9FIRM</name>
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        </submittedName>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
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            <end position="91"/>
        </location>
    </feature>
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            <end position="129"/>
        </location>
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        </location>
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            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUN64628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="235" mass="26659" checksum="6FE1880F47EC6C8E" modified="2016-09-07" version="1">MDRLFNMDNKFFTVMGRVADLIMLNVVFLICCLPIVTIGASLTALHYVTLKMARNEESYIIRSFFKSFKQNFKQATVINLIMLAVAAILYMDLRIVGNIGGTMSQVLYIVFFAFGILYLMVFLYIYPVLAKFYNSVKNTFRNAFLMAIRHLPYTVLMAVITLLPAGVFFIKSFRIQSMAIMLLCMFGFALEAFINGHFLVKIFDNYIPADADTQDTDLQNGNSAETSSAENDHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z3I2</accession>
    <name>A0A173Z3I2_9FIRM</name>
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        </submittedName>
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        </source>
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        </location>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="214" mass="22920" checksum="E9F06C1ECC9741C5" modified="2016-09-07" version="1">MLCLPAFNIGAFCLPFVQSFLPAMGSVTACMFDVGNSIMCTGGTYAFVAEYTAASGSKKGIDLKSFAKRLITSPPLVAYVVMFILAVANIDTPPVILTLIEPMAKANTFVAMLMLGLLFHIEFKKEYMGEIFKLIGIRHIFAAVCAVIFYFVLPFDLVIRQTLVLLCFAPMSAVAPAYTGMCGGDEGMASCANSVSILCSLVVITALLAIMGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z7U4</accession>
    <name>A0A173Z7U4_9FIRM</name>
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        <submittedName>
            <fullName evidence="8">Flp pilus assembly protein TadB</fullName>
        </submittedName>
    </protein>
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            </authorList>
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            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
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    </evidence>
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            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX64185.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="257" mass="29802" checksum="37982CA0C787B595" modified="2016-09-07" version="1">MKGKEKEQLYQKRNYDHYRFSMKELLKYMGQALALCIMADYLFYKSKWVLLLMLPVPVFYLKWQKNRMIRERRKNLNYQFKDALTSLSVAVQAGYSVESAVKTCVRDLERLYGKGTDIVEEFRYIESQQHISVPLEELFLDLGERSQIEDIENFASVFYTAKRTGGDMNRVIQKVSRMLGDKIDVKKEIEATLAAKKSEQMIMSLMPVGIILYLQMTSPGFLSVLYGNPFGIAAMSICLVIYAAAYWLGRRIVDIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z931</accession>
    <name>A0A173Z931_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_03348</name>
        <name evidence="2" type="ORF">ERS852478_00906</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002569240.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72754">
        <property type="protein sequence ID" value="CUN72754"/>
        <property type="gene ID" value="ERS852478_00906"/>
    </dbReference>
    <dbReference type="GeneID" id="61912446"/>
    <dbReference type="GeneID" id="66495687"/>
    <dbReference type="eggNOG" id="ENOG5033VRY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033731558" evidence="1">
        <location>
            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN72754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX67071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="101" mass="11448" checksum="9F2F1BEC355016E4" modified="2016-09-07" version="1">MNLRKSILALSVVAGIVAAPMTVFAAHTHSWGSPQYYGYEDEMPGIYDDWDKCATRHVYNYKQCLICGEVSIYEVETIEMSHKWVNGACVYCNKGYAKEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZDV3</accession>
    <name>A0A173ZDV3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">agrA</name>
        <name evidence="8" type="ORF">ERS852478_00943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053386.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73869">
        <property type="protein sequence ID" value="CUN73869"/>
        <property type="gene ID" value="ERS852478_00943"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="132"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN73869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="240" mass="27786" checksum="F24AF38121DCA605" modified="2016-09-07" version="1">MKLAICEDNPSHYEIIHTILQKYPPGAFEITHFASGDEFLRTVAENGCPYSIVLTDIDLGSDNVNGISLAEKINYISPDTQIIFISQYLQYATAVYETEHAYFIHKQQMEKYLPLALRTACQKLEKLHTRYLYFSGNSRNYQVLCSDILYLERNLRQTTIYTRTGTYTTKERLTALTERMKPDFCLCHNSFAVNLHAVRTYSHKGIILSDNTEIPVSRSYYQQFKDAFAFMMLAGHREVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZHL9</accession>
    <name>A0A173ZHL9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclodextrin-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cycB_3</name>
        <name evidence="2" type="ORF">ERS852478_01000</name>
        <name evidence="3" type="ORF">GT728_13485</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000034">
        <property type="protein sequence ID" value="MZL34189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577891.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75731">
        <property type="protein sequence ID" value="CUN75731"/>
        <property type="gene ID" value="ERS852478_01000"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033731978" evidence="1">
        <location>
            <begin position="29"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN75731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="417" mass="46269" checksum="D5937E1349344D5B" modified="2016-09-07" version="1">MKKRLLSGLLCGTLTMSLLGGTAIPVLADDDQTITMWTVFTGSDGDILREIVKDYNESNEDGIKVDIDIMDGSTLQAKLPTAISTNTAPDFVLMGIEYIYQYANNDMIIPLDDFWEKTGLDESNYLENVVDKSKVDGTLYGVPMQYNLQYLYYNKDLFEEAGLDPEQPPTTMEELAEDAKKLTNPDKNQYGIGFPTDYASYCEYLWSNGGDVVSEDGKENNLNSEANIKTLEWIQDLVLNENVSPQGLKAADADTMFQSGQLAMYTSGPWNINGLKQLGVNFGITAIPSGSDGAYAPEGGCAYMIPKSVDDSKKDAIYKWMAYWLSDDVLKEWSTRNGFPVWSNSLLEDEDIKSDEILTDVSDASKIGRNWHLNLDWGSQIDQNVMQPMMEQILSGTDVSEALQTASDTLDGIIAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZKR4</accession>
    <name>A0A173ZKR4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetylesterase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1 4">S-formylglutathione hydrolase FrmB</fullName>
            <ecNumber evidence="1 4">3.1.2.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">frmB</name>
        <name evidence="4" type="ORF">BWLFYP14_01366</name>
        <name evidence="1" type="ORF">ERS852478_01001</name>
        <name evidence="2" type="ORF">ERS852523_01215</name>
        <name evidence="3" type="ORF">GT728_13490</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
            <strain evidence="2 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.2.12" evidence="1 4"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000009">
        <property type="protein sequence ID" value="CUP30923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000034">
        <property type="protein sequence ID" value="MZL34190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577894.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000034.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000012_gene3123"/>
    <dbReference type="EnsemblBacteria" id="CUN75765">
        <property type="protein sequence ID" value="CUN75765"/>
        <property type="gene ID" value="ERS852478_01001"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP30923">
        <property type="protein sequence ID" value="CUP30923"/>
        <property type="gene ID" value="ERS852523_01215"/>
    </dbReference>
    <dbReference type="GeneID" id="66493226"/>
    <dbReference type="eggNOG" id="COG0627">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN75765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP30923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="278" mass="31876" checksum="1D65507AC49CCB6D" modified="2016-09-07" version="1">MALMEVNFFSKALMRPVTMNVILPVDKVFFGEETEEENKPFKTLYLLHGVMGNYTDWVTGTCIKRWAEEKNLAVVMPSGANMFYMDHPNANENYSEFIGKELVKITRRMFPLSHKKEDTFIAGLSMGGYGAIRNGLKYHDTFGYIAGLSSAMILEKMRTADDSSPMFFEKKSFLENVFGDLSRIKDCEINPEWIAENMKKDGIPFPHMYLACGLDDPLLPPNRKFRDTMQKLGVDVTYEEGPGAHEWDFWNRYIKRVLDWLPLDKDSKEGMNSGNVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZKZ4</accession>
    <name>A0A173ZKZ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_01393</name>
        <name evidence="1" type="ORF">ERS852478_01018</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707145.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76300">
        <property type="protein sequence ID" value="CUN76300"/>
        <property type="gene ID" value="ERS852478_01018"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBQ6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026989">
        <property type="entry name" value="TnpV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14198">
        <property type="entry name" value="TnpV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN76300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX64419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="125" mass="14901" checksum="E22E2EF6913A14F5" modified="2016-09-07" version="1">MKDLKTRITENGIDYVLVGDYYIPDLKLPEEKRSIGKWGRMHREYLKKQCYGRYSSLLLTGKLWSYLEDLDEQAEERFTCIVDQMKAAEGVTEELKRKDAMLWVQRCNNIRNRAEEIVLNEMVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZL03</accession>
    <name>A0A173ZL03_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine transporter SstT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Na(+)/serine-threonine symporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">sstT</name>
        <name evidence="9" type="ORF">ERS852478_01019</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29575"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:69999"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199881.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76329">
        <property type="protein sequence ID" value="CUN76329"/>
        <property type="gene ID" value="ERS852478_01019"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032329">
        <property type="term" value="P:serine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015826">
        <property type="term" value="P:threonine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01582">
        <property type="entry name" value="Ser_Thr_transp_SstT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023025">
        <property type="entry name" value="Ser_Thr_transp_SstT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN76329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="408" mass="43434" checksum="4B1C67B9553B0218" modified="2016-09-07" version="1">MKKVWDKWTRIALVKRILVGLILGAILGIAVPQATGIAILGDVFVSALKAIAPLLVFFLVISSLCNAGKSHGGVIKTVIILYMFSTVLAAVIAVFASMAFPVKMTLANAATDTSAPQGIVEVLNNLLLNVVANPVSSLVNANYVGILMWAVLLGLAFRAADKMTKKVLADVADGISMVVTWIINLAPFGIFGLVFNTVSTNGLDIFTTYGKLLLLLVGCMLFIYFVTNPLLVYWCIRQNPYPLIFHCLKRSALTAFFTRSSAANIPVNMKVCEEMGLDRDTYSVTIPLGATINMDGAAITITVMTMATAFTLGIHVDIPTAIILSLLAALSACGASGVAGGSLLLIPMACSLFGISDDISMQVVAVGFIIGVVQDSVETALNSSSDLLLSASAEFRQWRREGKEIKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZL55</accession>
    <name>A0A173ZL55_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione import ATP-binding protein GsiA</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_6</name>
        <name evidence="6" type="ORF">ERS852478_01026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199883.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76543">
        <property type="protein sequence ID" value="CUN76543"/>
        <property type="gene ID" value="ERS852478_01026"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN76543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="323" mass="36087" checksum="AB879BE8225C163C" modified="2016-09-07" version="1">MFKESDIVLSAKHIVKQFPASHGRTLTACNDINLNVYKGKTLGIVGESGCGKSTFVRMVISLDKPTSGEILYHGKNLADLSKKETWLNRQNMQMVFQDPLASFDPKMKIVDILTEPLINFGKLKKSEKEAKARELLEMVELPGDFVDRYPHNMSGGQRQRISIARALSLEPEILVCDEATSALDVSVQESVIELLVRLQKEKNISMLFICHDLALIRSFAHQIAVMYLGNIVEVIPGEDVTEHAVHPYTQALLGAQFSIHMDPSQKIQSIESEAPSPLDVPKGCPFQNRCEHCTDRCKAEMPKLKEIAPGHAVACFYVEEQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZU72</accession>
    <name>A0A173ZU72_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsmE</name>
        <name evidence="7" type="ORF">ERS852478_01067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199910.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPC010000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78976">
        <property type="protein sequence ID" value="CUN78976"/>
        <property type="gene ID" value="ERS852478_01067"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN78976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="248" mass="28217" checksum="DC72221C975031D7" modified="2016-09-07" version="1">MQRFFVESYQIEEEAHRIHINGTDVNHIKNVLRMKCGEDVWISDGGDKEYHCQIEELGEDEVLLHILYAQEPEYELPNKLYLFQGLPKADKMELIIQKAVELGAFSIIPVETKRCVVKLDVKKAAKKVVRWQQIAESAAKQSKRMLIPEIHEVMTYKQALEFAKQLDVKLIPYELAKGMKETREILSEIKPGQSVGIFIGPEGGFEEEEVAKALEAGAHAITLGRRILRTETAGLAILSVLMFQLENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZVB2</accession>
    <name>A0A173ZVB2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yrrK</name>
        <name evidence="4" type="ORF">ERS852478_01073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YqgF HJR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199913.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79165">
        <property type="protein sequence ID" value="CUN79165"/>
        <property type="gene ID" value="ERS852478_01073"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="YqgFc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN79165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="140" mass="16129" checksum="F8BFC3F63AD6B3FB" modified="2016-09-07" version="1">MRILGLDYGSKTVGAAISDPLGITAQGVETIWRKQENHLRQTLARIEELVSEYHVEKIVLGYPKNMNNTIGERARKSLEFKEMLERRTGLEVIMWDERLTTVEANRTLMEASVRRENRKQYLDQLAAVFILQGYLDSLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AI62</accession>
    <name>A0A174AI62_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methionine gamma-lyase</fullName>
            <ecNumber evidence="5">4.4.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mdeA_2</name>
        <name evidence="5" type="ORF">ERS852478_01299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.11" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380750.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88312">
        <property type="protein sequence ID" value="CUN88312"/>
        <property type="gene ID" value="ERS852478_01299"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2873">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018826">
        <property type="term" value="F:methionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN88312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="427" mass="46700" checksum="CA4B621E43C0A406" modified="2016-09-07" version="1">MSDFKVETKCLHSGYTPSKGEPCALPIYQSTTYKYDTTDEMGQLFDLKAEGYFYTRLQNPTNDAVAAKIADLEGGVAAILTSSGQAANFYAVFNICEAGDHVVAASTIYGGTFNLLAVTFKKLGIDCTFVDTDASPEEIAAAFRPNTKVLFAETIANPALVILDIEKFAKVAHEHEVPLIVDNTFATPVNCRPFEWGADIVTHSTTKYMDGHAVQVGGAIVDSGNFDWDAYGHKYHGLTEPDESYHGVIYTKQFGKKAYITKATSQLMRDLGSIPSPTNCFLLNLGLETLPLRVERHCYNAQKIAEFLNAHEKVSHVNYAGLPDDKYYALAQKYMNEGRTCGVISFELTGGREAAVRFMDSLKLATIATHVAASKTMILHPASHTHRQMNDEQLAEAGVSPGMIRLSVGIENVEDIIADIEQALKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ATS7</accession>
    <name>A0A174ATS7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotidyltransferase domain protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Nucleotidyltransferase domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Predicted nucleotidyltransferases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BWLFYP14_00378</name>
        <name evidence="3" type="ORF">ERS852478_01373</name>
        <name evidence="4" type="ORF">ERS852523_04118</name>
        <name evidence="6" type="ORF">GT712_19490</name>
        <name evidence="5" type="ORF">GT728_18640</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000083">
        <property type="protein sequence ID" value="CUQ14071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000073">
        <property type="protein sequence ID" value="MZL35142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000077">
        <property type="protein sequence ID" value="MZS91154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000002">
        <property type="protein sequence ID" value="VUX62214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705807.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000073.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000098_gene2881"/>
    <dbReference type="EnsemblBacteria" id="CUN90805">
        <property type="protein sequence ID" value="CUN90805"/>
        <property type="gene ID" value="ERS852478_01373"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ14071">
        <property type="protein sequence ID" value="CUQ14071"/>
        <property type="gene ID" value="ERS852523_04118"/>
    </dbReference>
    <dbReference type="GeneID" id="66494877"/>
    <dbReference type="eggNOG" id="ENOG5034AWR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN90805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUQ14071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL35142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS91154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX62214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="117" mass="13820" checksum="C0B031EA3A1BBE22" modified="2016-09-07" version="1">MLTCIRSKRQRDAAEYALRTIQSSCIRPYIKTIYLYGSCARGEEKYSSDVDLFLELSESFRSRPELKKYLYLLKSEVSSEELDDAETDLKIVVGDDWKRNKMLYYTNVRKEGIQIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B0M4</accession>
    <name>A0A174B0M4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized homolog of phage Mu protein gp47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200099.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94621">
        <property type="protein sequence ID" value="CUN94621"/>
        <property type="gene ID" value="ERS852478_01455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006949">
        <property type="entry name" value="Baseplate_J-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04865">
        <property type="entry name" value="Baseplate_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Baseplate_J" evidence="2">
        <location>
            <begin position="72"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN94621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="376" mass="41240" checksum="F629F0388E8BF6CB" modified="2016-09-07" version="1">MTEEFVTPEFIDNSDPDTIQSRMMNNLPVDISDMPADFPYDFTMPTAIEISRLIQYNLTRTLMLMFPLWAWGEWLDLHGVSAKVTRKQASRASGHVTVTGIAGTIIEEGTVFCTEGTTDVESVEFATTEEATIPEQGTVDIPVASVLTGATYNVTRNTVTLQKQPNENITSVTNENPIRGGTDEEDDDTYRERILEKLRSAEVSFVGCDADYVRWAKEVSGVGSAVVEPEWKGPGTVKVVVADPDGSAVGEETLKAVENYIVSPKDRLKRLAPIGASVTISTVQDMTMKYRAVIELESNYSVDNVKEAFLSALKTYYRTAKDNEEIRYTVVSALLSNTAGVIDFSGLKINSGTDNIAVAADYYPVTTLSDLDFTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BAW5</accession>
    <name>A0A174BAW5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704298.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000124.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96886">
        <property type="protein sequence ID" value="CUN96886"/>
        <property type="gene ID" value="ERS852478_01519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020378">
        <property type="entry name" value="DUF4186"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13811">
        <property type="entry name" value="DUF4186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN96886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="123" mass="14856" checksum="B8B75B4DF4B3BA24" modified="2016-09-07" version="1">MTKDEWYKQLFERLENSRFRSRFHLKQNDIDYIHEKGLDTIRKHAEDFITKREAPAYIPNDGKQTPMRGHPVFIAQHATATCCRECIRKWHKIQPGRELSQVQQEYLVDVIMTWIERELENAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BFS5</accession>
    <name>A0A174BFS5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome-partitioning protein parB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">parB_2</name>
        <name evidence="3" type="ORF">ERS852478_01579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008688042.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99881">
        <property type="protein sequence ID" value="CUN99881"/>
        <property type="gene ID" value="ERS852478_01579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="2">
        <location>
            <begin position="30"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN99881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="309" mass="35757" checksum="41CB38763C2FC50F" modified="2016-09-07" version="1">MAVKESSASKIKFKGVDALFGLSEEQECVREIPLDELDTFKNHPFKVFRDDKMEEMIESISEYGVLVPGIARPSNSGEKDYELVVGHRRKYACRELGLKTMPVIIRDMSDDEATVVMVDSNIQRENLLYSEKAFAYRMKYEALKRQGRRTDLTLVQVEPKLKKRWAAEMVGTEVGETMSTIKRYIRLTYLSNYLLEFVDKNELPFTVAVDLSYLKSNEQSLLLAFIGTTKKMPNGSQAKKLKELSQQKELTGEDIEKILRGEAKVNYQKISFSEKQLQKYFPPDYKKEQIEKIIFQLLDSWKAQTEQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BPD6</accession>
    <name>A0A174BPD6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacterial mobilisation protein (MobC)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_024720757.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01535">
        <property type="protein sequence ID" value="CUO01535"/>
        <property type="gene ID" value="ERS852478_01624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008687">
        <property type="entry name" value="MobC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05713">
        <property type="entry name" value="MobC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MobC" evidence="1">
        <location>
            <begin position="61"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO01535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="107" mass="12829" checksum="6B4D833CF24CA3B0" modified="2016-09-07" version="1">MAERKRNKEIHFYVTEEERKLIRRKMIESKTKNMGAYLRKMAIDGYIVNTDTTPLKKQYEEMHKIGVNINQIAKKVNITGDLYPEEMQELKEMVKELWRILRSSPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BQL2</accession>
    <name>A0A174BQL2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation initiation factor Spo0A C terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_024720749.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01928">
        <property type="protein sequence ID" value="CUO01928"/>
        <property type="gene ID" value="ERS852478_01638"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042173">
        <property type="term" value="P:regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014879">
        <property type="entry name" value="Spo0A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08769">
        <property type="entry name" value="Spo0A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spo0A_C" evidence="2">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO01928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="70" mass="8211" checksum="8153B44729E6663F" modified="2016-09-07" version="1">MREKTIYEKIAEKYNTTPEEVRREMQIAIDAGFDNPDPAVQEEWKKMTLKGERPTPEEVINYAVKKLKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BRP2</accession>
    <name>A0A174BRP2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stage V sporulation protein AB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_00248</name>
        <name evidence="2" type="ORF">ERS852478_01650</name>
        <name evidence="3" type="ORF">ERS852523_01302</name>
        <name evidence="5" type="ORF">GT712_09025</name>
        <name evidence="4" type="ORF">GT728_04655</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707239.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000057_gene2532"/>
    <dbReference type="EnsemblBacteria" id="CUO02350">
        <property type="protein sequence ID" value="CUO02350"/>
        <property type="gene ID" value="ERS852478_01650"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33914">
        <property type="protein sequence ID" value="CUP33914"/>
        <property type="gene ID" value="ERS852523_01302"/>
    </dbReference>
    <dbReference type="GeneID" id="66496113"/>
    <dbReference type="eggNOG" id="ENOG503152T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020144">
        <property type="entry name" value="SpoVAB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13782">
        <property type="entry name" value="SpoVAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO02350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP33914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX67407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="139" mass="15545" checksum="EF2657DC50EF936F" modified="2016-09-07" version="1">MLEQIFLGFTGLCSGFIIAGGLTGLMIGLSIIPRYAGITHTADHILLYEDITFWGTELGNLFFLFHWNIRFGTPFLILYGLFSGIFLGGWIMALAEMADIFPIFARRSRFQRGLSFTILCIAAGKTVGALIYYYNGWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C0H2</accession>
    <name>A0A174C0H2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Preprotein translocase subunit SecE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">secE</name>
        <name evidence="12" type="ORF">BWLFYP14_01183</name>
        <name evidence="8" type="ORF">ERS852478_01770</name>
        <name evidence="9" type="ORF">ERS852523_02366</name>
        <name evidence="11" type="ORF">GT712_12065</name>
        <name evidence="10" type="ORF">GT728_05715</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000024">
        <property type="protein sequence ID" value="CUP66094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000009">
        <property type="protein sequence ID" value="MZL32716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705380.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000018_gene14"/>
    <dbReference type="EnsemblBacteria" id="CUO07021">
        <property type="protein sequence ID" value="CUO07021"/>
        <property type="gene ID" value="ERS852478_01770"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP66094">
        <property type="protein sequence ID" value="CUP66094"/>
        <property type="gene ID" value="ERS852523_02366"/>
    </dbReference>
    <dbReference type="GeneID" id="66493427"/>
    <dbReference type="eggNOG" id="COG0690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO07021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP66094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL32716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS89788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX63824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="69" mass="7859" checksum="FF2F3A4A68793A27" modified="2016-09-07" version="1">MQGNEKSAGKSQKKSWFQGLQSEFRKIVWTDRNELIKQTIVVVCVSIVLCVLISVMDSFILEGINLLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C0Z4</accession>
    <name>A0A174C0Z4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdopterin adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.75</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mog</name>
        <name evidence="5" type="ORF">ERS852478_01737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in the biosynthesis of molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.75" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200204.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05999">
        <property type="protein sequence ID" value="CUO05999"/>
        <property type="gene ID" value="ERS852478_01737"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="4">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO05999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="162" mass="17581" checksum="2FA830376630A895" modified="2016-09-07" version="1">MKRVAIITSSDTGYRGEREDLSGPAIREIVEKNGYEVVAEDVLPDDRKMLSERMAEIADSGTAELILTTGGTGFSPRDITPEATEDIIDRRVPGIPEAMRAYSMTITKRAMLSRSTAGIRKKTLIINLPGSPKAVKESLEYIIDALGHGIEIMTGEAGNCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C2E8</accession>
    <name>A0A174C2E8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nusG_1</name>
        <name evidence="5 9" type="synonym">nusG</name>
        <name evidence="12" type="ORF">BWLFYP14_01182</name>
        <name evidence="8" type="ORF">ERS852478_01769</name>
        <name evidence="9" type="ORF">ERS852523_02365</name>
        <name evidence="11" type="ORF">GT712_12070</name>
        <name evidence="10" type="ORF">GT728_05720</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">2789STDY5834863</strain>
            <strain evidence="9 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 16 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 17">BIOML-A1</strain>
            <strain evidence="11 16">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000024">
        <property type="protein sequence ID" value="CUP66067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000009">
        <property type="protein sequence ID" value="MZL32717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705379.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000018_gene15"/>
    <dbReference type="EnsemblBacteria" id="CUO06997">
        <property type="protein sequence ID" value="CUO06997"/>
        <property type="gene ID" value="ERS852478_01769"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP66067">
        <property type="protein sequence ID" value="CUP66067"/>
        <property type="gene ID" value="ERS852523_02365"/>
    </dbReference>
    <dbReference type="GeneID" id="66493428"/>
    <dbReference type="eggNOG" id="COG0250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="7">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO06997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP66067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL32717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS89789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX63823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="171" mass="19241" checksum="ED737656D52D40EF" modified="2016-09-07" version="1">MSEAKWYVVHTYSGYENKVKVDIEKTIENRHLEDQILEVRVPLQEVAELKNGALKQVQKKMFPGYVLLNMVMNDDTWYVVRNTRGVTGFVGPGSKPVPLTEEEMLPLGIKKEEIQVDFAEGDTVVVTGGAWKDTVGVITALNVQKQTATINVELFGRETPVEISFAEIKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C2N5</accession>
    <name>A0A174C2N5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH peroxidase</fullName>
            <ecNumber evidence="6">1.11.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rbr3A</name>
        <name evidence="6" type="ORF">ERS852478_01755</name>
        <name evidence="7" type="ORF">GT712_12095</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.11.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578258.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06549">
        <property type="protein sequence ID" value="CUO06549"/>
        <property type="gene ID" value="ERS852478_01755"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016692">
        <property type="term" value="F:NADH peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01046">
        <property type="entry name" value="Rubrerythrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045236">
        <property type="entry name" value="Rubrerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Ferritin-like diiron" evidence="5">
        <location>
            <begin position="51"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO06549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS89794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="181" mass="19825" checksum="6129DB0C5F77D432" modified="2016-09-07" version="1">MTKWVCSVCGYVYEGEKAPEACPVCKAPADKFVKQDSELSWAAEHVVGVAQGSSEDIMADLRANFQGECSEVGMYLAMARVAHREGYPEIGLYYEKAAYEEAEHAAKFAELLGEVVTDSTKKNLQMRVEAENGATAGKTDLAKRAKAANLDAIHDTVHEMARDEARHGKAFAGLLKRYFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C3N6</accession>
    <name>A0A174C3N6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Predicted ATPase (AAA+ superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01753</name>
        <name evidence="4" type="ORF">GT712_12105</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578262.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06490">
        <property type="protein sequence ID" value="CUO06490"/>
        <property type="gene ID" value="ERS852478_01753"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="2">
        <location>
            <begin position="313"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO06490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="471" mass="53871" checksum="315EA9185587C640" modified="2016-09-07" version="1">MKFIGRKMELEKLNAEYERDGGFVVIYGRRRVGKTTLIKEFLKKKTAFYFLATEELESQSMKRLAGVVARMTKNSLLQKAVFTDWLDLFQVIADYEPDKKKVLVIDEFPYLVKTNPAFPSILQNAWDEILKDSNVMLILSGSLIGMMQKHALSYDSPLYGRRTAQMRLAPLPFTDVYDALALPFDKAVEQYAVTGGVPKYLEFFEDGRDLVDQLKDVVLSKSGFLYEEPFFLLKSESMTAVNYFSIIKAIADGNHKLGKIAGALGQETQALTPYLSTLADLGFIEKRTPVTKKNPEKSRKGLYFIADNFIRFWFRYVYPYKGELELDNMQIVLDEIRKDFIEKFVAFAYEDICKDIFASVCKQGEIPFVPSRIGSYWLNDYDGDTEIDVMAIDNQNKRIFAGECKYHVKPVDAPVYFSLKEKVDGAAEIRKAYPGYDVIFGLFSKSGFTQRMLDIAKENASIVLINEEHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C3N8</accession>
    <name>A0A174C3N8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylthioribulose-1-phosphate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.109</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mtnB</name>
        <name evidence="2" type="ORF">ERS852478_01766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.109" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06899">
        <property type="protein sequence ID" value="CUO06899"/>
        <property type="gene ID" value="ERS852478_01766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO06899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="231" mass="25772" checksum="C61204F590259F6D" modified="2016-09-07" version="1">MENIREQMEKLEISSEAINEVLFVAKRMDDKGLVNSFAGNISTKKDGKIYITPTGQNKGLLTPEKIAVINEDGERIWGMKETSEVIMHSMAYDICEANGWDVGGVVHSHSKILTAFSMACMDVETEALPEMMGNFHKIPCVPYGAPGTKYILTMAEPYLADGYRIVLLGNHGSLAVGKTVEDAMNVVEACESIAEQVLITKYILKSEAPLDRDEVARFFDIYKENREKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C3Z5</accession>
    <name>A0A174C3Z5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">D-alanyl-D-alanine carboxypeptidase dacB</fullName>
            <ecNumber evidence="11">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dacB_4</name>
        <name evidence="11" type="ORF">ERS852478_01757</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06600">
        <property type="protein sequence ID" value="CUO06600"/>
        <property type="gene ID" value="ERS852478_01757"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="10">
        <location>
            <begin position="66"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO06600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="332" mass="36380" checksum="34A10CF4D1BEEDC4" modified="2016-09-07" version="1">MAARRRGKKKSGRSYAWRYRGRIVACVFVEVIIICALVIMIGWNKGVKEWFEQFEQPVLKEVDISGINSPNAILMQARGGKILGEINGEAQIYPASMTKIMTVILGIENFDDLDEKITLTNEMFSGLYEQDATQAGFQPGEEVRVIDLLYGAMLPSGAECCIALADTISGSEADFAELMNKKAGKLGMENTHFCDSTGLHNPDHYSTVKDIAVLMKYCIKNDTFREIVETSRHSTGVTNIHPDGITYYSTMFKNLSDPTVTGGKILGGKTGYTSEAGHCLVSFAEIEGREYIFVSAGASGADGNTIPHIQDAVTVYNRVGAAIEEKMNDNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CC05</accession>
    <name>A0A174CC05_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">adhE_1</name>
        <name evidence="3" type="ORF">ERS852478_01875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200404.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11061">
        <property type="protein sequence ID" value="CUO11061"/>
        <property type="gene ID" value="ERS852478_01875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd08179">
        <property type="entry name" value="NADPH_BDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034802">
        <property type="entry name" value="NADPH_BDH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="7"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO11061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="393" mass="43120" checksum="DEC98B46F96ADBE7" modified="2016-09-07" version="1">MARFTLPRDIYHGKGCLEELKNLKGKKAVLVVGGGSMKRQGFLDKAVNYLKEGGMEVQLIEGVEPDPSVETVMKGAKIMQEFQPDWIVAMGGGSPIDAAKAMWTFYEYPDTKFENLITPFGFPELRQKAKFAAIPSTSGTATEVTAFSVITDYHTGIKYPLADFNITPDVAIVDPELVEGLPVKQVAYTGMDALTHAIEAYVSTLHCPYTDPLALQAIEMVLAYLPASYNKNMEAREQMHYAQCLAGMAFSNALLGIVHSMAHKTGAAFSTGHIPHGCANAIYLPYVIKYNAKDPVAAERYAEIARRMGLEGTCQQALINSLCEKIDEFNVRLNIPKTLKDFGIQEEEFKEKVAKIAELAVGDACTGSNPRAIDPANMEKLLTCTYYGTEVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CFS6</accession>
    <name>A0A174CFS6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA dehydrogenase, short-chain specific</fullName>
            <ecNumber evidence="4">1.3.8.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.1" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10830">
        <property type="protein sequence ID" value="CUO10830"/>
        <property type="gene ID" value="ERS852478_01867"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004085">
        <property type="term" value="F:butyryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="2">
        <location>
            <begin position="33"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO10830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="120" mass="12906" checksum="46CE59D3E00DDBF6" modified="2016-09-07" version="1">MGIPYPKEYGGAGLDALSYAIAVEELARVDGGTETTALDKGDYYLLNGGKIFITNAPKADTYVVFAIITPDIGTRGISAFIVEKGFEFGDNYDKMGIRSSSTAELIFNDVKIPKENLLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CHH0</accession>
    <name>A0A174CHH0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Serine/threonine-protein kinase BtrW</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">btrW</name>
        <name evidence="6" type="ORF">BWLFYP14_02209</name>
        <name evidence="2" type="ORF">ERS852478_01921</name>
        <name evidence="3" type="ORF">ERS852523_01975</name>
        <name evidence="5" type="ORF">GT712_17440</name>
        <name evidence="4" type="ORF">GT728_10730</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000018">
        <property type="protein sequence ID" value="CUP54652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000023">
        <property type="protein sequence ID" value="MZL33660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000051">
        <property type="protein sequence ID" value="MZS90791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="CUO12574">
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        <property type="gene ID" value="ERS852478_01921"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP54652">
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        <property type="gene ID" value="ERS852523_01975"/>
    </dbReference>
    <dbReference type="GeneID" id="66493873"/>
    <dbReference type="eggNOG" id="COG2172">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <location>
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            <end position="133"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUP54652.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZL33660.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MZS90791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="135" mass="15210" checksum="BE1E5622D0170387" modified="2016-09-07" version="1">MKSITEEAKIENIAVITDFVNSILEANGCSAKVQMEIDIAIDEIFGNIAYYAYTPKTGEATVQVEIKNFPERLELTFIDKGIPYNPLENKDPDVTLDIEKRKIGGLGIFLVKEMMDEVSYEYADGKNILKLKKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CLM5</accession>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sbcC</name>
        <name evidence="4" type="ORF">ERS852478_01925</name>
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        <name type="scientific">Blautia wexlerae</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="5"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <end position="576"/>
        </location>
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            <end position="382"/>
        </location>
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    <feature type="coiled-coil region" evidence="1">
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            <end position="502"/>
        </location>
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    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="791"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="852"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO12708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1117" mass="127771" checksum="0531E2B03B55847E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CW71</accession>
    <name>A0A174CW71_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02009</name>
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        <name evidence="3" type="ORF">GT728_08885</name>
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        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="1 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO96088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577200.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2239"/>
    <dbReference type="EnsemblBacteria" id="CUO16080">
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        <property type="gene ID" value="ERS852478_02009"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96088">
        <property type="protein sequence ID" value="CUO96088"/>
        <property type="gene ID" value="ERS852523_00073"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043721">
        <property type="entry name" value="DUF5662"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO16080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO96088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="184" mass="21972" checksum="2490608A767F6E6E" modified="2016-09-07" version="1">MHPWLHFKTITRHKLLVMHYCFRAGMYKQGLLHDLSKYAPVEFLVGCKYYQGDRSPNNAEREDTGISKSWLHHKGRNKHHFEYWVDYAPGDEHIINGVPMPRKYIAEMVMDRISASRNYLGDKYDQHQPLDYYLKGKEKLWFIHPKTKRDLEGLLRILNDHGEEVLISYIKNVYLKKDKALERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CWL8</accession>
    <name>A0A174CWL8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Trans-2-enoyl-CoA reductase [NADH]</fullName>
            <shortName evidence="9">TER</shortName>
            <ecNumber evidence="9">1.3.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">fabV</name>
        <name evidence="15" type="ORF">BWLFYP14_00434</name>
        <name evidence="12" type="ORF">ERS852478_02014</name>
        <name evidence="14" type="ORF">GT712_10235</name>
        <name evidence="13" type="ORF">GT728_08860</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="13 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 19">BIOML-A1</strain>
            <strain evidence="14 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18177"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TER reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.44" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000018">
        <property type="protein sequence ID" value="MZS89436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707571.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16230">
        <property type="protein sequence ID" value="CUO16230"/>
        <property type="gene ID" value="ERS852478_02014"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050343">
        <property type="term" value="F:trans-2-enoyl-CoA reductase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01838">
        <property type="entry name" value="FabV_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024906">
        <property type="entry name" value="Eno_Rdtase_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024910">
        <property type="entry name" value="Enoyl-CoA_Rdtase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010758">
        <property type="entry name" value="Trans-2-enoyl-CoA_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37480">
        <property type="entry name" value="PTHR37480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07055">
        <property type="entry name" value="Eno-Rase_FAD_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12242">
        <property type="entry name" value="Eno-Rase_NADH_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12241">
        <property type="entry name" value="Enoyl_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl_reductase" evidence="11">
        <location>
            <begin position="81"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Eno-Rase_FAD_bd" evidence="10">
        <location>
            <begin position="320"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="110"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="138"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="269"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Plays an important role in discriminating NADH against NADPH" evidence="9">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO16230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL33302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS89436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VUX62350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="394" mass="44093" checksum="98DCAF42FC214DE3" modified="2016-09-07" version="1">MIIEPKVREYICTTAHPQGCAESVRNQADYACKQGMVNGTKKALIIGCSTGYGLASRICALENCGADTLGIMFERQANGRRTATPGWYNTAEFHRLASGKGVYAKTINGDAFSKEIKEKAIELIKQDLGKVDLVVYSLAAPRRTDAEGKTWSSCLKTTDEPFTEKSLDLRNNEITEKTVEPATEEEVLSTVKVMGGEDWADWIDALKAADVLTENAVTVAYSYIGPELTYPIYYHGTIGTAKQHLQKTMSEINQAHPDVRAVISVNKGLVTQASAAIPVVPLYFAILYKVMKRAGNHENCIQQIARLFTQKLYTPEGFRTDENGFIRMDDYELLPEIQEEVKKCWKAVTTDTVNQYCDIDGYWEDFYHMFGFHYSDIDYTQDVDANVEINGIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D6M4</accession>
    <name>A0A174D6M4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19939">
        <property type="protein sequence ID" value="CUO19939"/>
        <property type="gene ID" value="ERS852478_02113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO19939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="30" mass="3468" checksum="C3DFD0C6B74A9BB2" modified="2016-09-07" version="1">MPEIDFLNKKTFTKTSGMINLRKRATIESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7K5</accession>
    <name>A0A174D7K5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tyrosine recombinase XerD</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Tyrosine-type recombinase/integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xerD_3</name>
        <name evidence="8" type="ORF">ERS852478_02115</name>
        <name evidence="10" type="ORF">GT712_19625</name>
        <name evidence="9" type="ORF">GT728_11590</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">BIOML-A1</strain>
            <strain evidence="10 12">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000027">
        <property type="protein sequence ID" value="MZL33822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000084">
        <property type="protein sequence ID" value="MZS91177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993164.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19998">
        <property type="protein sequence ID" value="CUO19998"/>
        <property type="gene ID" value="ERS852478_02115"/>
    </dbReference>
    <dbReference type="GeneID" id="66493760"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="98"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO19998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL33822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS91177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="280" mass="32249" checksum="99C8846AD5DC2923" modified="2016-09-07" version="1">MYEEIFNQIRSAANKRNLKDSTIHAYCTSVAHFLNRTAKDIDALTTDDVDIFLTEKKLSGISPETYNHYHSGIRFFYKKILKKNWDDDDIPRMKRDRKLPTVLTKAEISAILDATPNLKHKAMIATMYSGGLRVSEVTHLHYDDISRTNKTIHIRDGKSRSDRYTLLADRTLEILTEYWFQCGRPRGILFPSSWTGDYLTKDSVIQFFRESAERAGIQKHVSTHCLRHSFASHLFESGCDIKYIQALLGHRDPKSTEIYLHVSNKTLLGIKSPFDEMGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DLC5</accession>
    <name>A0A174DLC5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperone protein HtpG</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">High temperature protein G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">htpG</name>
        <name evidence="8" type="ORF">BWLFYP14_01495</name>
        <name evidence="7" type="ORF">ERS852478_02266</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705508.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO25139">
        <property type="protein sequence ID" value="CUO25139"/>
        <property type="gene ID" value="ERS852478_02266"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="6">
        <location>
            <begin position="31"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="461"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO25139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX64642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="690" mass="79808" checksum="06AAAF5A92799320" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DP88</accession>
    <name>A0A174DP88_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chaperone protein DnaJ</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dnaJ_3</name>
        <name evidence="4" type="synonym">dnaJ_1</name>
        <name evidence="3" type="ORF">ERS852478_02335</name>
        <name evidence="4" type="ORF">ERS852523_01606</name>
        <name evidence="5" type="ORF">GT728_12350</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO27293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP43555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000029">
        <property type="protein sequence ID" value="MZL33970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381072.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000029.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000136_gene979"/>
    <dbReference type="EnsemblBacteria" id="CUO27293">
        <property type="protein sequence ID" value="CUO27293"/>
        <property type="gene ID" value="ERS852478_02335"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP43555">
        <property type="protein sequence ID" value="CUP43555"/>
        <property type="gene ID" value="ERS852523_01606"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO27293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP43555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL33970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="215" mass="24205" checksum="1ED8B9CEB38C7E52" modified="2016-09-07" version="1">MIDPYSILGISRDASDEEVKKAYRKMSRKYHPDANIDNPNKEQAEEKFKQVQQAYEQIMKEREQGIDYGNYGSNNYGGFGGFSGQADSGYQDEESMRRQAAANYIQSGHYREAMNVLQSLSQRNGQWYYLSSMANMGLGNNVNALNDIKQAIRLEPDNVQYQMVLQQMEGGGNWYQEMQNPFGGMPTGGDDYCMKLCLANMACSLCCPGSGIFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DXI1</accession>
    <name>A0A174DXI1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381484.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29917">
        <property type="protein sequence ID" value="CUO29917"/>
        <property type="gene ID" value="ERS852478_02398"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020299" evidence="2">
        <location>
            <begin position="24"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO29917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="354" mass="39526" checksum="B37843B33D746456" modified="2016-09-07" version="1">MKKIAAMVLAGVLAAVPVSTTGAAEFQDGADTQNFIWAAGEETSTDTDESKGVSANDSVVEGLDKPLVFYPNTYYKFNVTGAGTQNTNPVEGDVRWTPLYWSLSLKPQESDIHRKWEIGSAKGIYTKVERAYNIYVFFQREEYTGGIWEKNDIVQPVRYQFNAAPLTEQGGSYKYLIGGIGYKILNEREVSVTGLAAEYNVIQIPATVVINDKVYKVTTIDKNAFSGNKEITDVIFGNNVTTIGKYAFSQCPNLRNIRFGSRVKRIGSNAFAQCTKLRNFILPASVRHIDARAFYQCPAVKVIRINSTALNYVGKKAFAVNKTVTIRLPEKLFARYQKLIKASNVYSKTRFVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E2W5</accession>
    <name>A0A174E2W5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF2971)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200754.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32121">
        <property type="protein sequence ID" value="CUO32121"/>
        <property type="gene ID" value="ERS852478_02454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021352">
        <property type="entry name" value="DUF2971"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11185">
        <property type="entry name" value="DUF2971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO32121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="481" mass="56543" checksum="A68192126F8980CE" modified="2016-09-07" version="1">MKLYHYRSISSALLEIENGTFHFASKEELNDPLEGFVRVFWQGDKMAWEGLFRHYIYSVARALELYILKADDETLYHGTLVADVHCYKNNFFEKILLKLGEEFITDTDVQNLAGVYGDNCLKVSEKELQYILFYIHNNALIRCLEEFKKNKFVPAEEAEKQIKLLNFSLSVEKLVDAIKKVFSNEKMRVQTIESMEEIFEEMKEFSYIMKGAENDIFLHGKGSEEQIYNNDGNSVVQQHRKWLIVMADFPKVFVAQLRDMIYPKSYVVCFSKKNDNSAMWGNYADCHKGVCLIYDTGDEAKLKVGGRHIPLDVRAISYGGESIECNFFQTLGRLTMVQIREWLLGVDGVSSCYEAFSDVEEWRKRYWKIYDAKIYRKTKNWEHEKEFRVAVSNTFGEFDVPQKQNMSFDWNLLKGVIFGIRTSEYDKKQILDKLIKHKDELSDFTFYQAEYSAEEQKIKIRKKKFWRLINYKGKVDGTEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E3J0</accession>
    <name>A0A174E3J0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional repressor CzrA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Transcriptional repressor SdpR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">czrA</name>
        <name evidence="4" type="synonym">sdpR</name>
        <name evidence="4" type="ORF">BWLFYP14_00118</name>
        <name evidence="2" type="ORF">ERS852478_02418</name>
        <name evidence="3" type="ORF">ERS852523_03256</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000044">
        <property type="protein sequence ID" value="CUP91698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1146"/>
    <dbReference type="EnsemblBacteria" id="CUO30600">
        <property type="protein sequence ID" value="CUO30600"/>
        <property type="gene ID" value="ERS852478_02418"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP91698">
        <property type="protein sequence ID" value="CUP91698"/>
        <property type="gene ID" value="ERS852523_03256"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO30600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP91698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="101" mass="11268" checksum="0A1627CCDD6CCA40" modified="2016-09-07" version="1">MKGCDELLGLQDTLKALADPIRREILNLLKGGRLSAGEICEHFSVTGASISRHLAILKDADLIRSKREGKFIYYELNTSVLEDVMLWITDLKGVSDYEGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E6Z7</accession>
    <name>A0A174E6Z7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6444 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02163</name>
        <name evidence="4" type="ORF">ERS852478_02458</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32219">
        <property type="protein sequence ID" value="CUO32219"/>
        <property type="gene ID" value="ERS852478_02458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045618">
        <property type="entry name" value="DUF6444"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20042">
        <property type="entry name" value="DUF6444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6444" evidence="3">
        <location>
            <begin position="135"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO32219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="306" mass="35646" checksum="EFE4DDA451BD6C3A" modified="2016-09-07" version="1">MPDTYDHITLMCRLKAAQRRNKELESGERYIQLEELHQKEYNVYEHKIEKLKKELADAHKETIRVRNYWFQVLEDMLREFEKAQKRSAQELRKMEIRALNAEKQREDALDKAAVFRHQFYEAASRLEEEQGKNLKLRAQINRDYENSSIPSSKAVRRKKITNNREKTGRRPGGQPGHKGHCRKRQEPTQPVILLPPPEEVLEDCAFKKTARTIVKQMVSIRMVLNVTEYHADVYYNSHTGERAHAAFPDGVIDDVNYDGSIRAFLFLLNNDCCTSIDKSRAFLSDLTGGKLNISKGMISRLNRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EFE3</accession>
    <name>A0A174EFE3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF512 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Putative FeS-containing Cyanobacterial-specific oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02593</name>
        <name evidence="5" type="ORF">GT728_02710</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577072.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36423">
        <property type="protein sequence ID" value="CUO36423"/>
        <property type="gene ID" value="ERS852478_02593"/>
    </dbReference>
    <dbReference type="GeneID" id="66494120"/>
    <dbReference type="eggNOG" id="COG1625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007549">
        <property type="entry name" value="DUF512"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045375">
        <property type="entry name" value="Put_radical_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04459">
        <property type="entry name" value="DUF512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19238">
        <property type="entry name" value="Radical_SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ_6" evidence="2">
        <location>
            <begin position="7"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Radical_SAM_2" evidence="3">
        <location>
            <begin position="69"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="DUF512" evidence="1">
        <location>
            <begin position="222"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO36423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL32130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="460" mass="52805" checksum="CB8F9589069EF9F9" modified="2016-09-07" version="1">MKKNLHIISRVLPDSIGEELELEPGDALLSINGQPVEDVFDYRYLMNDEFVTLLIRKKNGEEWELEVEKEYEDDLGVEFENSLMDEYRSCSNHCIFCFIDQMPPGMRETLYFKDDDSRLSFLQGNYVTLTNMSDYDLDRIIKFHLSPINVSFQTMNPKLRCKMLHNRFAGDALAKVDRLYKGDVTMNGQIVLCKGINDRDELEYSLEKLSEYAPVLQSVSIVPVGLSRYRKGLYPLESFDKEDARYLISQVERWQKIMVKKHGIHFVHASDEWYILAGYELPEEGRYDGYLQLENGVGMMRLLETEVKERLEQLEGDDREVNATVATGRLAAPYIGKMIKLVQKKFPNVQAEVYAVKNNFFGEKITVSGLITATDLMDQLAQRNLGEKVLIPCNMLRSGEDVFLDDLTVEDVRQALKTEVVVVDEPGADLVNCLIEAPDHKKIRRRQIYEQTGSSDSGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EJW6</accession>
    <name>A0A174EJW6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MotA_ExbB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BWLFYP14_02471</name>
        <name evidence="10" type="ORF">ERS852478_02603</name>
        <name evidence="11" type="ORF">ERS852523_00200</name>
        <name evidence="12" type="ORF">GT728_02760</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">2789STDY5834863</strain>
            <strain evidence="11 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 17">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000002">
        <property type="protein sequence ID" value="CUP00076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000050">
        <property type="protein sequence ID" value="VUX66099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703914.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000003_gene1617"/>
    <dbReference type="EnsemblBacteria" id="CUO36689">
        <property type="protein sequence ID" value="CUO36689"/>
        <property type="gene ID" value="ERS852478_02603"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00076">
        <property type="protein sequence ID" value="CUP00076"/>
        <property type="gene ID" value="ERS852523_00200"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="9">
        <location>
            <begin position="119"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO36689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP00076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL32140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX66099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="546" mass="61558" checksum="484480CDEEBA9F11" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ENS3</accession>
    <name>A0A174ENS3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclodextrin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cycB_4</name>
        <name evidence="2" type="ORF">ERS852478_02671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO39121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070102130.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39121">
        <property type="protein sequence ID" value="CUO39121"/>
        <property type="gene ID" value="ERS852478_02671"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020918" evidence="1">
        <location>
            <begin position="28"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO39121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="421" mass="44595" checksum="8CC1AB92DFD46B26" modified="2016-09-07" version="1">MRKNVKKVIAPLLAAAMALSCTVCVSAAEDETIKLTVWGAEEDQNLLKELTDKFQEKYADQKFDIQIGVESESTAKDTILTDVEAGADVYAFADDQLPDLVKAGALLKLDDYAEALQLADTTLDDVKAANVEGAIDAATIDGSLYAFPRAADNGYFLYYDSSVISEEDAASWDSLLEAADKAGKKVGMTLASGWYNASFFYGAGFTTGLNDDGTTTMDWNGTSADGYTGVDVVKGMLDITSNPAFMAVADGDMSNQLASGNLAACVSGTWDAITAKEIFGDGYAATKLPTFTVGDKQVQQGSVAGYKYVGVNGYSENSGWAVLLAEYLTNEESQQMFFDQRESGPSNKNVATSDSVQENVALAALAAQSEYAQAQKVGGKYWDPAKTFGELIAQGTLSADDDNAIQEALDNLVEGAAASVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EPR7</accession>
    <name>A0A174EPR7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_14</name>
        <name evidence="7" type="ORF">ERS852478_02695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379941.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40112">
        <property type="protein sequence ID" value="CUO40112"/>
        <property type="gene ID" value="ERS852478_02695"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO40112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="279" mass="31451" checksum="2A8C144FD160EB73" modified="2016-09-07" version="1">MENNKKKSIIPTIILTILSLFWIYPIILILLNSLKKESAITTTGVFELPLGEIWNGFTNYVASVTQMDFLKSFWYSLVISVMSVVLILLCCSMCAWYIVRVNGVLSKILYYLFIFSMVVPFQMVMFTLAKTADTLKLNTPYNICIIYLGFGAGLAVFMFTGFVKGIPLEIEEAALIDGCNPLQVFFKILIPILKPTIISTAILQLMWVWNDYLLPTLVLDIKKYRTIPMAVQYFRGSFGHVQMGPMMASIMIDIIPIVIVYLVCQKYIIEGVVAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EV73</accession>
    <name>A0A174EV73_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CCA-adding enzyme</fullName>
            <ecNumber evidence="8">2.7.7.72</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cca</name>
        <name evidence="8" type="ORF">ERS852478_02711</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200853.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40568">
        <property type="protein sequence ID" value="CUO40568"/>
        <property type="gene ID" value="ERS852478_02711"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032810">
        <property type="entry name" value="CCA-adding_enz_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13735">
        <property type="entry name" value="tRNA_NucTran2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="5">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="6">
        <location>
            <begin position="170"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTran2_2" evidence="7">
        <location>
            <begin position="295"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO40568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="441" mass="50320" checksum="53578E29F3D5B014" modified="2016-09-07" version="1">MILEIPKNAETILHILEKAGYEAYVVGGCVRDSILGRSPDDWDITTSAKPEQVKALFHRTVDTGLQHGTVTVLMEKEGYEVTTYRVDGEYEDGRHPKEVTFTASLEEDLKRRDFTINAMAYNPSSGLVDLFGGLEDIERKIIRCVGDPLERFTEDALRIMRAVRFSAQLGFAIEEETRKALKVLAPNLKHVSAERIQVELVKLLMSPHPDYLRVAYEAGITAEFLPEFDACMTTSQNTPHHCYTVGEHILHSLCHVRADKVLRITMLLHDIGKPVVRKTDENGRDHFKMHGIAGEKMAAQILRRLKFDNDTIRKVTRLVKWHDDRPEGMTKAVRRAVNRIGEDLFPYYLEVQQADMLAQSDYRRTEKQERLDKVKEAYETIINEHQCVSLKTLAVTGKDLIEAGYKPGREIGETLNRLLEVVLVDPQKNQKEILLGMLDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EXV3</accession>
    <name>A0A174EXV3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative purine permease ygfU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ygfU</name>
        <name evidence="8" type="ORF">ERS852478_02746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200885.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41488">
        <property type="protein sequence ID" value="CUO41488"/>
        <property type="gene ID" value="ERS852478_02746"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO41488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="463" mass="48387" checksum="AAAF3BA75373FE88" modified="2016-09-07" version="1">MKRGSIFETDGIPRMSEALPLAMQHVVAMIVGCVTPAIIVSGAVPGGLSREDQVILIQSALVIAALSTLLQLFPIGGKAKFAIGSGLPIIMGVSFAYVPSMQAIAESYGIAAIMGAEIVGGIVAVVMGLLVKKIRVFFPPLITGTVVFTIGLSLYPTAINYMAGGTSSPNYGSWQNWAIAFFTLIVVTALNHFGKGIWKLASILIGIIVGYLVSIPFGMVDFSSIGEAGVCQLPSLMHFGVQFEPSSCVALGILFAINSIQAIGDYSATTIGAMDRTPKDDELQRGIVGYGLSNVAGALLGGLPTATYSQNVGIVTTTKVINRWVLGLAAAILGIAGLVPKFSAILTTIPQCVLGGATVSVFASIAMTGMKLVASAEMDYRNSSIVGLAAALGMGVSQATAALASFPTWVTTIFGKSPVVLATIIAVMLNVILPKTRDEQKEEAKKKIKIEQKLEEDHREFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F0Y6</accession>
    <name>A0A174F0Y6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7 10">inner membrane ABC transporter permease protein YcjP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_15</name>
        <name evidence="10" type="synonym">ycjP_2</name>
        <name evidence="10" type="ORF">BWLFYP14_01050</name>
        <name evidence="7" type="ORF">ERS852478_02796</name>
        <name evidence="9" type="ORF">GT712_15305</name>
        <name evidence="8" type="ORF">GT728_08445</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">BIOML-A1</strain>
            <strain evidence="9 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000016">
        <property type="protein sequence ID" value="MZL33223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000036">
        <property type="protein sequence ID" value="MZS90399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705243.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43217">
        <property type="protein sequence ID" value="CUO43217"/>
        <property type="gene ID" value="ERS852478_02796"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO43217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL33223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS90399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX63688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="279" mass="31424" checksum="7703562DF38B6ED9" modified="2016-09-07" version="1">MKKKKPTIPSIIKWVIALILVVMQVYPFFYVFTSSFKSLDDFRQLPAYALPSKWVLTNFINVFTKSHMLTYFKNSIIVLIGVLIPLLLFALMAGFALSKIKFKGRKFVLNYFLLGLMLPMQVALIPLFTIFNKMGLINTYPAIILPQIAFSLSYSIQLFYSFSKFFPEEMLEAAIIDGCSPIGCFFKMVVPMSLNSIITVATMQAVFCWNEYINAYTFTRSTDMKTITLGLNDFVGSMGLTDWGGTFAAITVTVLPVFIFYFFSSKKMLAGMTAGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F1V2</accession>
    <name>A0A174F1V2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate starvation-induced protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sbp</name>
        <name evidence="7" type="ORF">ERS852478_02813</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic sulfate-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200940.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43681">
        <property type="protein sequence ID" value="CUO43681"/>
        <property type="gene ID" value="ERS852478_02813"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901681">
        <property type="term" value="F:sulfur compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902358">
        <property type="term" value="P:sulfate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01005">
        <property type="entry name" value="PBP2_CysP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034408">
        <property type="entry name" value="Sulphate/thiosulphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005669">
        <property type="entry name" value="Thiosulph/SO4-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30368">
        <property type="entry name" value="PTHR30368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00971">
        <property type="entry name" value="3a0106s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00757">
        <property type="entry name" value="PROK_SULFATE_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021259" evidence="6">
        <location>
            <begin position="24"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO43681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="332" mass="37396" checksum="9B89F6E0C0870444" modified="2016-09-07" version="1">MIRKLFAFGLAVVLALMPVQTFGKTVSITNVSYDPTREMFEQYNKIFEDHWKEKTGEDVEVIQSHGGSGKQALEVANGLDADVVTLALEYDIESIENAGLIKAGWKDKFDNDSSPYTSTIVFLVKKGNPRDIKDWDDLTKKGVGVVTPNPKTSGGARWNYMAAWAYADKKYGGDEAQMKEFIKKLYRNVVVLDSGARGATTSFVENGQGDVLVAWENEAYLSMRDYPDEYEIVTPSVSILAQPSVAVVDEVVDYRDTRDVATEYLNYLYSDEAQEIAAENYFRPTNEKILKKHSDTFDLNINLANISDYGGWDKVQEKHFTDGGIFDQIYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F505</accession>
    <name>A0A174F505_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">phoR_6</name>
        <name evidence="9" type="ORF">ERS852478_02860</name>
        <name evidence="11" type="ORF">GT712_16355</name>
        <name evidence="10" type="ORF">GT728_14400</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 14">BIOML-A1</strain>
            <strain evidence="11 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000038">
        <property type="protein sequence ID" value="MZL34357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000043">
        <property type="protein sequence ID" value="MZS90589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380566.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45164">
        <property type="protein sequence ID" value="CUO45164"/>
        <property type="gene ID" value="ERS852478_02860"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031967">
        <property type="entry name" value="PhoR_single_Cache-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16736">
        <property type="entry name" value="sCache_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="232"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO45164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL34357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS90589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="447" mass="50803" checksum="4BABDC3B6E68B990" modified="2016-09-07" version="1">MKHKIFSHTSLLIILSVILTFLAAGTVMYNRYDIYMKQGVRDEAAYIKTGLEEDGDVFLSDRVGDATSSRITLLGKDGQVLFDSIENPEEMENHSNRPEFIEAEKQGSGEMVRYSDTLSKQTFYYAVKLKDDQVLRVARTTDSLLVTMLTSFLLLGGLVCVILVIELFLVQKQTRKLIEPINRIDLEHPLEHVCYEELRPLLFRLDQQNRQIQKQLEDLKNAESARKEFTANVSHELKTPLMSISGYAELMMNGMVPPDKMQDFSGRIFHESERLSNLVADIIQLSRLDEKNGETMFEQVDIGELGEDVINNLQNRAAKKKINLEYTGGPAQMQGVRHVLYEMFYNITDNAIRYTPDGGDVKVFVGKLNGKPYFRVEDNGIGIPESEQQRIFERFYRVDKSHSRETGGTGLGLSIVKHGAVLHHAKILLDSEPGKGTKMEILFDQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F6H0</accession>
    <name>A0A174F6H0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02822</name>
        <name evidence="2" type="ORF">ERS852523_03648</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000058">
        <property type="protein sequence ID" value="CUQ02167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43940">
        <property type="protein sequence ID" value="CUO43940"/>
        <property type="gene ID" value="ERS852478_02822"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ02167">
        <property type="protein sequence ID" value="CUQ02167"/>
        <property type="gene ID" value="ERS852523_03648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO43940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUQ02167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="42" mass="4752" checksum="EFEEAFD8BD812911" modified="2016-09-07" version="1">MAGYAAWDVSMLLFTATHSRELRYVKSNVSITAEGNDIYEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F8P8</accession>
    <name>A0A174F8P8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_17</name>
        <name evidence="8" type="synonym">ycjP_23</name>
        <name evidence="7" type="ORF">ERS852478_02855</name>
        <name evidence="8" type="ORF">ERS852523_03695</name>
        <name evidence="10" type="ORF">GT712_16330</name>
        <name evidence="9" type="ORF">GT728_14425</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
            <strain evidence="8 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BIOML-A1</strain>
            <strain evidence="10 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000061">
        <property type="protein sequence ID" value="CUQ03567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000038">
        <property type="protein sequence ID" value="MZL34362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000043">
        <property type="protein sequence ID" value="MZS90584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019160841.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000092_gene68"/>
    <dbReference type="EnsemblBacteria" id="CUO45059">
        <property type="protein sequence ID" value="CUO45059"/>
        <property type="gene ID" value="ERS852478_02855"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ03567">
        <property type="protein sequence ID" value="CUQ03567"/>
        <property type="gene ID" value="ERS852523_03695"/>
    </dbReference>
    <dbReference type="GeneID" id="66494758"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="81"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO45059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUQ03567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL34362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS90584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="292" mass="32135" checksum="3DCD12EEF288857C" modified="2016-09-07" version="1">MAKEKEARRPFNLKKEVKLLPGYIILLLWVIFTIALLGWVFGASFSTTAEIFQGKALKFESGLHFENYAKAWNGAGVAGFFGNSLIYSVISCTILILVCAPAAYVLSRFDFIANKFIQTSFVSAMGVPAIMVVLPLFSIISGMGILNNVAAGRTVLIILYVGINVPYTTIFLLTFFSNISRTYEEAAAIDGCPPMRTFWKIMFPMAQSGIVTVTIFNFINIWNEYFLSLIFASSDKLKPVAPGLYGMINSMKYTGDWAGMFAAVIIVFLPTFILYIFLSEKIIGGVTGGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FCT3</accession>
    <name>A0A174FCT3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transposase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_02909</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO46758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060656.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO46758">
        <property type="protein sequence ID" value="CUO46758"/>
        <property type="gene ID" value="ERS852478_02909"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039552">
        <property type="entry name" value="IS66_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024463">
        <property type="entry name" value="Transposase_TnpC_homeodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024474">
        <property type="entry name" value="Znf_dom_IS66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13817">
        <property type="entry name" value="DDE_Tnp_IS66_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13007">
        <property type="entry name" value="LZ_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13005">
        <property type="entry name" value="zf-IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LZ_Tnp_IS66" evidence="4">
        <location>
            <begin position="48"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="zf-IS66" evidence="3">
        <location>
            <begin position="133"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="2">
        <location>
            <begin position="198"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_IS66_C" evidence="5">
        <location>
            <begin position="490"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO46758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="558" mass="64477" checksum="F27FA229AFAAFB93" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FFU9</accession>
    <name>A0A174FFU9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705165.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47290">
        <property type="protein sequence ID" value="CUO47290"/>
        <property type="gene ID" value="ERS852478_02930"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033TFS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO47290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="409" mass="48179" checksum="0DF25B39BFB08070" modified="2016-09-07" version="1">MKNRMQDLDFEQNVAFDKVQEYEFTRRAAQRFRQVVSLDSFEDEDADVIFHYLYKEMELVSFGDHLKRYIYERAELEEPFSEIPQEVYKEIVVDSFKETYTPKSMNPTSTKLSALVNNWLNQASVKRETVFLLGFGLKMTTEDVSDFLTRVLKEQDFDFYNPDEVIYWYCYSTQQGYHKAEELKKKYEILAPVEVENTQVLYGSNLCLDTEEKLIDYLARLKSKRVDPISEKSQAFQEFTKLLYHAKQIIAGLYQHDEEEKGGDKVWTAERITPSDVEKVICSGIPINKMGNLKKMSASILAKHFSQKRFSRQRITNILSHKLPVERFDLITLEFFIVSQEMEDDDPFNRYKHFLDEIQDILLRCGMGEIYIVNPYECFLLMCLLTDCPLAVFSEIWEKSYEEGEAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FG78</accession>
    <name>A0A174FG78_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO49262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49262">
        <property type="protein sequence ID" value="CUO49262"/>
        <property type="gene ID" value="ERS852478_02987"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO49262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="45" mass="5435" checksum="EC94A4BDC667C4DD" modified="2016-09-07" version="1">MNLKEQHIGIPTNDIVHFLPFWENRVKFFTIEGPNKEKVEFSQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FGH7</accession>
    <name>A0A174FGH7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 11">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">upp</name>
        <name evidence="12" type="ORF">ERS852478_02939</name>
        <name evidence="13" type="ORF">ERS852523_03114</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">2789STDY5834863</strain>
            <strain evidence="13 15">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="3 11"/>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000039">
        <property type="protein sequence ID" value="CUP87320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055152742.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000068_gene3403"/>
    <dbReference type="EnsemblBacteria" id="CUO47500">
        <property type="protein sequence ID" value="CUO47500"/>
        <property type="gene ID" value="ERS852478_02939"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP87320">
        <property type="protein sequence ID" value="CUP87320"/>
        <property type="gene ID" value="ERS852523_03114"/>
    </dbReference>
    <dbReference type="GeneID" id="66494701"/>
    <dbReference type="eggNOG" id="COG0035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="11">
        <location>
            <begin position="131"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="11">
        <location>
            <begin position="199"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO47500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUP87320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="209" mass="23083" checksum="E64E7B970FAF707F" modified="2016-09-07" version="1">MENVYIMNHPLIQHKISMLRNKNTGTNEFRKLVEEIGILMGYEALRDLPVENVEVETPIETCMTPMISGKKLAVIPVLRAGLGMVNSILTLVPSAKVGHVGLYRDPVTHEPHEYYCKLPEAIDERISVIVDPMLATGGSAEAAVDFVKKQGGKNIKFMCIIAAPEGLKRLHEAHPDVQIYCGHLDRELNDHAYICPGLGDAGDRIFGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FIE5</accession>
    <name>A0A174FIE5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable dihydroxyacetone kinase regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">TetR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03006</name>
        <name evidence="4" type="ORF">GT728_10095</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000021">
        <property type="protein sequence ID" value="MZL33539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201070.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50034">
        <property type="protein sequence ID" value="CUO50034"/>
        <property type="gene ID" value="ERS852478_03006"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039532">
        <property type="entry name" value="TetR_C_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14278">
        <property type="entry name" value="TetR_C_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO50034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="185" mass="22287" checksum="6250FFD37556E5B5" modified="2016-09-07" version="1">MSGFTKEIIAKTFTELLDEKSMSKITVKDIVERCGVNRNTFYYHFKDIPDVVEFILKKKWDEILEHPQDRASILECMEEMADLVRNNRKVMLNVYRSVKKDTFLFYMNEISNYIIMEYFRKNADQFDLDEGEIRILIQYYKCLFMGFLMEWLDNNLKSDFGEEMRQASRLFEKHPELHAVLNRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FMH6</accession>
    <name>A0A174FMH6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anaerobic sulfatase-maturating enzyme</fullName>
            <ecNumber evidence="6">1.1.99.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Radical SAM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atsB</name>
        <name evidence="8" type="ORF">BWLFYP14_03523</name>
        <name evidence="6" type="ORF">ERS852478_03008</name>
        <name evidence="7" type="ORF">GT712_01420</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.99.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705038.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50098">
        <property type="protein sequence ID" value="CUO50098"/>
        <property type="gene ID" value="ERS852478_03008"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="108"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO50098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS87783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX67248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="449" mass="51050" checksum="F01FB4255023A288" modified="2016-09-07" version="1">MKLMDKAKQAALAAAVKTGLGYLEKDPEVNIPKLMELVDKFVPDGWYESQRNAIRNAIQNKDSNWYKLILRIYELDPGVREAFFTNFIINASLKGSALQEETAEENNCNVPWAILLDPTSACNLHCTGCWAAEYGHKLNLDFDTICSIVEQGRKMGTYMYIYTGGEPLVRKKDLMRICEKYPDCEFLSFTNGTLIDEEFCQEMLRVKNFVPAISLEGSEEANDGRRGEGVYQKVMHAMELLKAHKLPFGVSTCYTSANVDSVSSEEFFDHIIDCGALFVWFFHYMPTGNDAVVELMPNPQQREKMYHKIREYRSTKAIFGMDFQNDAQYVGGCIAGGRRYLHINANGDVDPCVFIHYSNANIYENTLLEALKSPIFMAYHDGQPFNENMLRPCPMLENPQKLRKMVEESGAKSTDLQSPESVEHLCAKCDAYAEHWAPKAEELFPVKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FWM2</accession>
    <name>A0A174FWM2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">sensor Histidine kinase GRAS</fullName>
            <ecNumber evidence="5 6">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">graS_2</name>
        <name evidence="6" type="ORF">BWLFYP14_00683</name>
        <name evidence="5" type="ORF">ERS852478_03146</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="5 6"/>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO54702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000015">
        <property type="protein sequence ID" value="VUX62934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005924876.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000091.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54702">
        <property type="protein sequence ID" value="CUO54702"/>
        <property type="gene ID" value="ERS852478_03146"/>
    </dbReference>
    <dbReference type="GeneID" id="56863530"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="126"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO54702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX62934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="337" mass="39027" checksum="935D31D2C7C75878" modified="2016-09-07" version="1">MNSRRYWKNRLPFLLTNLVCMAALTVFLLVCGNSVSAVVLILIVWALILLTGLVLTYWKRKRQMKKLLDMAEQLSERYLISEVMELPEQAEDQVYYQLLKMAGKSMLEQIGEVERERLEYKEYIEQWIHEIKTPITAMKLLCENHRTDWTKELLLELEKTNRFTEQALYYARSEHTEKDYSVREMALSQVVHQAIADNKYLLLQGGMRLEVEEMQDTVYSDEKWVRFILNQLIANAVKYRTEQPVLRISTHKRQDQVVLVMEDNGIGIAASDLPRIFEKGFTGQNGRMVQQSTGIGLYLCKRLCEKLGIGIAAESSEQGTAISLAFHINCLIHEVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FXY6</accession>
    <name>A0A174FXY6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005335911.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPF010000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53696">
        <property type="protein sequence ID" value="CUO53696"/>
        <property type="gene ID" value="ERS852478_03116"/>
    </dbReference>
    <dbReference type="GeneID" id="43514868"/>
    <dbReference type="GeneID" id="64114869"/>
    <dbReference type="eggNOG" id="ENOG502Z939">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014973">
        <property type="entry name" value="DUF1835"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022123">
        <property type="entry name" value="DUF3658"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08874">
        <property type="entry name" value="DUF1835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12395">
        <property type="entry name" value="DUF3658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO53696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="320" mass="36556" checksum="FE0F26D970713105" modified="2016-09-07" version="1">MIEIVFGESACGSLKIAQTYGKGKYRGSAVSIFMRHEDGSVPSSDEMKKAQLQAQEQERIAWENAIPLGGKSSDVYCFDMALSVGDISDNGIGEQRKNIFKKMLSVCFVEDLDYQVEEKIQKIKTTLTSVIERYVAGEEIRIWYSYNPDELCGMYWLMKQLQPLNCQTTIYLVKLPTWEYGKENTMTSKIAWGEVSPGEWGNYITLQEKANPVFLSACTMKWNQLQNENAPLRAMLNGKLQSVSEDIYDSFILREIAEQPEQFKMAIVIGNVLGKYQLGISDVWISNRIDKMLEDGVLEIIQDAPKGETNYRRILRKRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FXZ1</accession>
    <name>A0A174FXZ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002595102.1">
        <property type="nucleotide sequence ID" value="NZ_JAAINB010000067.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53430">
        <property type="protein sequence ID" value="CUO53430"/>
        <property type="gene ID" value="ERS852478_03106"/>
    </dbReference>
    <dbReference type="GeneID" id="57969711"/>
    <dbReference type="GeneID" id="64114879"/>
    <dbReference type="GeneID" id="66495708"/>
    <dbReference type="eggNOG" id="ENOG5032RVM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO53430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="65" mass="7339" checksum="0595970D5C5EF476" modified="2016-09-07" version="1">MAKNKTEIHVTTVFDGELDATDVFVSLISQKYGKTNTKEYLAKKKELKYNEDEVQKSRIPSGLCG</sequence>
</entry>
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            <taxon>Clostridia</taxon>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="gene ID" value="ERS852478_03138"/>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="688"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO54487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="792" mass="87688" checksum="AC531AF76CDDE0B0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G2J8</accession>
    <name>A0A174G2J8_9FIRM</name>
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        <submittedName>
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    </protein>
    <gene>
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        <name evidence="8" type="ORF">ERS852478_03206</name>
        <name evidence="10" type="ORF">GT712_14600</name>
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        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 13">BIOML-A1</strain>
            <strain evidence="10 12">BIOML-A12</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        <property type="gene ID" value="ERS852478_03206"/>
    </dbReference>
    <dbReference type="GeneID" id="66493901"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13124">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PG_synth_SpoVB"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
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            <dbReference type="EMBL" id="MZS90266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
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        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="542" mass="58842" checksum="8487B50C54F95426" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G4V2</accession>
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        <submittedName>
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        </submittedName>
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        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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            <dbReference type="EMBL" id="CUO56146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="291" mass="33083" checksum="2D6B98EDB085DAE3" modified="2016-09-07" version="1">MIHTIENDYLRVSVDDHGAELCSIFDKVHNREVIWQADSAYWKRHAPVLFPNVGRHFEDHYRINGVEYPSSQHGFARDSEFTCVDMTADSITHRLKSSDATRENYPYDFELKIKHVLEKNQVSVCWEVISLNDETMYFTIGGHPAFNVPAGGIGSQEQYHLTFDGQDSLSYLLIDMSSGTAVADKAYTLELENGSCLIDAHMFDKDALIFDDQIEKAGIAFPDGTPYVELICHGFPSFGIWSVPGSPFVCLEPWMGRCDDFGFKGELPEKKYINTLDKDEIFTASYEIKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
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    <name>A0A174G5Y4_9FIRM</name>
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        <submittedName>
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        </submittedName>
        <submittedName>
            <fullName evidence="2">Spermidine/putrescine-binding periplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">potD_1</name>
        <name evidence="2" type="ORF">ERS852478_03188</name>
        <name evidence="3" type="ORF">ERS852523_01924</name>
        <name evidence="4" type="ORF">GT728_04475</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000018">
        <property type="protein sequence ID" value="CUP53302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000007">
        <property type="protein sequence ID" value="MZL32474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577627.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000009_gene1465"/>
    <dbReference type="EnsemblBacteria" id="CUO56249">
        <property type="protein sequence ID" value="CUO56249"/>
        <property type="gene ID" value="ERS852478_03188"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP53302">
        <property type="protein sequence ID" value="CUP53302"/>
        <property type="gene ID" value="ERS852523_01924"/>
    </dbReference>
    <dbReference type="GeneID" id="66495745"/>
    <dbReference type="eggNOG" id="COG0687">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019808">
        <property type="term" value="F:polyamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015846">
        <property type="term" value="P:polyamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001188">
        <property type="entry name" value="Sperm_putr-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00909">
        <property type="entry name" value="SPERMDNBNDNG"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014251356" evidence="1">
        <location>
            <begin position="24"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO56249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP53302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="344" mass="38135" checksum="93304552E9B8677A" modified="2016-09-07" version="1">MKKRVLAVVMCALMAGTAFTGFKDAGDDKELVLFTWEGMFPQEVLDDFEKETGVKVVYSNFDTDETMLEKLSMAKGGDYDIVIADDYILETAIQEGLAEKLDKDSLENIGNINPLYQGQFYDPDDEYTVPYGAGIPLIVYDPEQVDIDIKGYKDLWDPSLEDSIALTANYRVINGITQLSMGESMNEEDVDVIKKTGEKLLELAPNVRLIQDDNTQNALLNGEASVAFLYTSQVTAALAENPDLKVVYPEEGLGFGIMGMFIPSEAPDKDAAYSFMDYIMQPEVAAKCTDYIGYYSTNKAADELVNPDLVVPDDVTKGEIVQNVSQDADAQYQKNWTEFKAACD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G7X5</accession>
    <name>A0A174G7X5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable CtpA-like serine protease</fullName>
            <ecNumber evidence="5">3.4.21.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_03215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060603.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57248">
        <property type="protein sequence ID" value="CUO57248"/>
        <property type="gene ID" value="ERS852478_03215"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="97"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO57248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="396" mass="43109" checksum="2C42389AE8A1745C" modified="2016-09-07" version="1">MKNKEFWKGAVAGALVVTCIGTGAFAGTGLAAKGTALGDRKCTSKLAYLEELIDRYYLGDKDEEKLQEGLYAGLLYGLDDPYSRYYTAEEYDSENSSNEGSYVGIGILMEKNKEGGVKIVECYEGGPGEKAGLEEGDIISAIDGEDITEDEVSDVADIVRNSDKDSVVLTVHREGAEDAMEITVPVTDVELPSVFHEMLDSKIGYIRITQFTGVTGEQYQEAFDDLQKQGMEKMIVDLRDNPGGLLDSVCDVLRKILPEGLIVYTEDKDGNREEEKCDGKNELRIPLAVLVNESSASASEIFAGAVQDYGIGTIVGTTTYGKGVVQSIRQLSDGSAIKLTVANYYTPKGNNINKTGIKPDIEVSLDTSLLNKNKDEITHDEDNQLQEAIKAVEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G9H5</accession>
    <name>A0A174G9H5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="5 11">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">trpE</name>
        <name evidence="14" type="ORF">ERS852478_03233</name>
        <name evidence="15" type="ORF">GT712_16685</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 16">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="5 11"/>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000045">
        <property type="protein sequence ID" value="MZS90649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381369.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57768">
        <property type="protein sequence ID" value="CUO57768"/>
        <property type="gene ID" value="ERS852478_03233"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="13">
        <location>
            <begin position="30"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="12">
        <location>
            <begin position="226"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO57768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZS90649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="495" mass="56396" checksum="BD3BB117FD630815" modified="2016-09-07" version="1">MYPTLETIRQLAQTKEYRRIPLCRELYADRYTPVEVMRILRKASRHCYLLESASQTEVWGRYSFLGYEPSMEITCTDRTLKIRTTDAEGKTEETVRQVTHPGDTLREIIRKYKTPVMEKMPPFTGGLVGYFSYDYIKYSEPKLKLEDREQQDFRDMDLMLFDQVIVFDHFRQKVLLITGVMADDLEASYEKAVKKLEEMAQLIRNGEHMEFEPLRLQSEIQPKFPKEKYAEMVEKAKHYIREGDIFQVVLSNPMRAKATGSLFDTYRVLRASNPSPYMFYFSSDDIELAGASPETLAKLENGTLSTFPLAGTRPRGKTREEDKELEEGLLKDEKELAEHNMLVDLGRNDIGKISKIGTVKVEKYLCVERFSHVMHLGSTVTGIIRDDKDAVDAVDAILPAGTLSGAPKFRACQIIEELEQSKRGIYGGAIGYLDFAGNLDTCIAIRLVYKKNGEICIRSGAGIVADSVPEKEFQECCNKARAVVQAIEQAQEGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GKS0</accession>
    <name>A0A174GKS0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted AAA-ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201314.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61748">
        <property type="protein sequence ID" value="CUO61748"/>
        <property type="gene ID" value="ERS852478_03355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018631">
        <property type="entry name" value="AAA-ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012547">
        <property type="entry name" value="PDDEXK_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09820">
        <property type="entry name" value="AAA-ATPase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08011">
        <property type="entry name" value="PDDEXK_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA-ATPase_like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO61748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="528" mass="60933" checksum="9314DEC96FB98876" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GL47</accession>
    <name>A0A174GL47_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO62721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201351.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62721">
        <property type="protein sequence ID" value="CUO62721"/>
        <property type="gene ID" value="ERS852478_03382"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022623" evidence="1">
        <location>
            <begin position="28"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO62721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="208" mass="22528" checksum="B7F2E8A2469EE9EC" modified="2016-09-07" version="1">MKIAKKFMTLALAAALGVGCATVGVGAAPSNTSDLAAVAPSKTSETTVDSKQSSIYEVVKELEKTQGFADLQAKYKDLADAFKQINDGTMKMEDFIKVLKSLSVDEADKADLEDAIAKLEGKMIVTFVNEFNVLKPEEAKPNDDGTYEVKLNVPSLTDTMEGIQLWVYSKDGTKKFVVIDPVNIDKEGKTLTVNLNDGDFFMVIADAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GLG6</accession>
    <name>A0A174GLG6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="1">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63384">
        <property type="protein sequence ID" value="CUO63384"/>
        <property type="gene ID" value="ERS852478_03406"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="1" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="2">
        <location>
            <begin position="196"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO63384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="365" mass="40052" checksum="2A8EC05F5D1A79AF" modified="2016-09-07" version="1">MYNKIQMGIEGNKKQKEGTILMKEIRTEDAVGHILCHDITQIIKDVKKGVLFKKGHIVREEDIPLLLSVGKEHLYVWEKKEGILHENEGAEILYKICAGDSDTMHGSDIKEGKIELIADIDGVLKIRREALLAVNSLGEMMIASRHGDFPVKKGDKLAGTRIIPLVIEKEKMDRAAEVAGTEPIFSILPYKKKKVGIVTTGSEVQKSLITDTFTPVLRDKFAKFPSEVIGQTKPGDDMEQITADILKFIEEGADMVVCSGGMSVDPDDRTPGAIKATGTRIVSYGAPVLPGAMMLVSYYEKDGRQIPILGLPGCVMYAKNTIFDLLLPRLMADDEITLSEINQLGEGGLCLNCDVCTFPNCGFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GLW3</accession>
    <name>A0A174GLW3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO62367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62367">
        <property type="protein sequence ID" value="CUO62367"/>
        <property type="gene ID" value="ERS852478_03376"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO62367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="56" mass="6375" checksum="7C0ECB9AB47C237A" modified="2016-09-07" version="1">MLAILSDEELGDKITMEQYYYNHMNKAQQAAYHSILSGVKNLADEFQIPALEGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GPF1</accession>
    <name>A0A174GPF1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Recombination protein F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02280</name>
        <name evidence="3" type="ORF">ERS852478_03446</name>
        <name evidence="4" type="ORF">GT712_16210</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000042">
        <property type="protein sequence ID" value="MZS90561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704383.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000068.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64522">
        <property type="protein sequence ID" value="CUO64522"/>
        <property type="gene ID" value="ERS852478_03446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="9"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="243"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO64522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="455" mass="51994" checksum="76B4C5193AC53682" modified="2016-09-07" version="1">MCEFNIQEIELFNYRQFEDKKFVLNSRMNVFAGKNGSGKTTVLEAANVVLGAYLAAFKTYVPSRFVFNIKSTDARRKTQISDDSRILTAGAIPQYPCKVSCKAAWNIDYESIGFQRVLLKQDGRTKFGGKNPMQQTVIEWESKIANADHSDEDVILPLVLYLSSARLWKDGNKRTVKTGVLSRTDAYSHCLDAQHGLDIAFRYIDTLKAVAVEENDGKIFPAYEVILWAVNEAFRDELKSGEKIIFSTKYEDDIIALRTSEGTVLPFQMLSDGYRNVIKIILDIAARMCILNPYLKEKALQETPGIVLIDEIDLSLHPTWQKRIIGILKQLFPKIQFICATHSPFIIQSLEEGELITLDQPLESEYSGESIEDISEDIMGVVLPQYSEKKRKIYEASKLYFEALTQAKSQEDIDRLGKRLAELEAEYSENPAYMAWVHQQYLEQKWKVKKNETNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GVY1</accession>
    <name>A0A174GVY1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060662.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66882">
        <property type="protein sequence ID" value="CUO66882"/>
        <property type="gene ID" value="ERS852478_03519"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO66882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="146" mass="16915" checksum="60871B1C1867F04C" modified="2016-09-07" version="1">MSIKITPDKYPQIIEVYNTEGKTAAYDLMRSCYEIKNPTCVMKRMKADKSLGYNYDTDRFESDSHKEDDIFLNLEMLCENKIETSDRSEGAISRNDRIKAMENMVHSLISDRLLELSKYVLLDPIGKRILIDKSSMQTDGYQVLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GYV2</accession>
    <name>A0A174GYV2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0246 protein BWLFYP14_02351</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yaaA_2</name>
        <name evidence="3" type="synonym">yaaA</name>
        <name evidence="5" type="ORF">BWLFYP14_02351</name>
        <name evidence="2" type="ORF">ERS852478_03481</name>
        <name evidence="4" type="ORF">GT712_16525</name>
        <name evidence="3" type="ORF">GT728_16050</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0246 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708186.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65685">
        <property type="protein sequence ID" value="CUO65685"/>
        <property type="gene ID" value="ERS852478_03481"/>
    </dbReference>
    <dbReference type="GeneID" id="66493926"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00652">
        <property type="entry name" value="UPF0246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005583">
        <property type="entry name" value="YaaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30283">
        <property type="entry name" value="PTHR30283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03883">
        <property type="entry name" value="H2O2_YaaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO65685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="253" mass="29507" checksum="90B05B783E6D4085" modified="2016-09-07" version="1">MKIILSPAKKMITDTDSIAPDGLPEFIEKTTEIQSWLKSKSKEELKTIWKCNDKITEQNFNRLENMDLYHLLTPAVLSYEGIAFQYMAPSVFEDSQFEYVQNHLRIISAFYGVLKPRDGVTPYRLEMQAKVGIGETKNLYEYWGDLLYRSVIDNSRIIINLASKEYSKCIEKYLTRQDRYITITFCELSGDKLVTKGTYAKMARGEMVRFMAENRIENPEDIKKFDRLGYSFRSDLSSDAEYVFERKTEITSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZI1</accession>
    <name>A0A174GZI1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201430.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68034">
        <property type="protein sequence ID" value="CUO68034"/>
        <property type="gene ID" value="ERS852478_03556"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO68034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="67" mass="7852" checksum="5D401414EDAEDD35" modified="2016-09-07" version="1">MKKLINGERYNQEIAMHTGYHLQITATEAAYLVSGGRYFTRTDDLEYRGRVMQHPGMRDYLANELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZR4</accession>
    <name>A0A174GZR4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-ribazole phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.73</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobC_2</name>
        <name evidence="1" type="ORF">ERS852478_03505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.73" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060675.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66526">
        <property type="protein sequence ID" value="CUO66526"/>
        <property type="gene ID" value="ERS852478_03505"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043755">
        <property type="term" value="F:alpha-ribazole phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO66526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="186" mass="22010" checksum="90B6616C5123017C" modified="2016-09-07" version="1">MGNLYFLRHCKTQFNADGMISGCLDSELIENEITYQEEMMNWDNVTIFSSDLMRCKKTLGILLENIRISPVIVYTSALRERNMGLFEGKRRADLQKKYPQYFINQRFCHQFTPPQGESFYDFLQRVDGFINNEFLPYKNRNVQENFIICAHNQILKLLYCRLQNVSIEENWMSLDFPSGTVVKIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H0R4</accession>
    <name>A0A174H0R4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted NTPase (NACHT family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66660">
        <property type="protein sequence ID" value="CUO66660"/>
        <property type="gene ID" value="ERS852478_03510"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO66660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="595" mass="71317" checksum="4893C0E5EF5535E9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H192</accession>
    <name>A0A174H192_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66850">
        <property type="protein sequence ID" value="CUO66850"/>
        <property type="gene ID" value="ERS852478_03518"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IstB_IS21" evidence="1">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO66850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="133" mass="15289" checksum="CFB73F853C7536CC" modified="2016-09-07" version="1">MIATGIGRNACEAGYKVLFVNAKELVDQLYEDMQKGYLKETLKQISKIPLLIIDELSYLKMDKERESLFFQIIRQRYEKSSLIITTNLPMGRWDELFTGKLAAAAILDRLVHHCHVISITGDSYRVKGSKTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H456</accession>
    <name>A0A174H456_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201436.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68187">
        <property type="protein sequence ID" value="CUO68187"/>
        <property type="gene ID" value="ERS852478_03562"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO68187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="252" mass="30114" checksum="9FF8A4CCD0ADA85A" modified="2016-09-07" version="1">MSKTNEDYFYDNLIYDSFDESHPYPGKCYKDPFWVCEHEPITLQEYADRRCISYETVRRQVKKYRADLIPHIRKVGKTQYLDDQAVEFLEEHRRPQAQPEDSQIVRNQIQKLSDTVKQNASNMDIAQRLSQEIGSLQNDNSHLKVKIEQLKQDLQEQECLYKESSEQYRELLEQYNELKTELAVSHKEYENLEETMRHLKTELRMVKQELSTSKNFQKVLNSQVHYYQDIIAGRDPSDPFKDLDFDTDLDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HD50</accession>
    <name>A0A174HD50_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379847.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71266">
        <property type="protein sequence ID" value="CUO71266"/>
        <property type="gene ID" value="ERS852478_03661"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="244" mass="28037" checksum="66CAB84F5C0743BB" modified="2016-09-07" version="1">MIEQLLGTALLCCIITAFFYCLFYKIACKSNINDFEADSPYIGDYASSIIVFLAISSLTLLIVVYFYITISPKLPKFLNDSGFTFAFLQLGAGFFIRLLHKIFFFTIVKITKSTSYHKLTSSEISWTWLILCFIYGIVFLINKECTIAFTYFVIDISYFFWLDSSCSSIIEKLSSIKKLSKSYWYVIIFIGLTAFIILRYHSKAQIFFAFIGLLIGIILSIIAMQYSLKRHCKKIDDHSHSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HES6</accession>
    <name>A0A174HES6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS982-like element ISRmsp1 family transposase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transposase DDE domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03679</name>
        <name evidence="3" type="ORF">GT712_12645</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000024">
        <property type="protein sequence ID" value="MZS89895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708342.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000084.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71668">
        <property type="protein sequence ID" value="CUO71668"/>
        <property type="gene ID" value="ERS852478_03679"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025668">
        <property type="entry name" value="Tnp_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13612">
        <property type="entry name" value="DDE_Tnp_1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tnp_DDE_dom" evidence="1">
        <location>
            <begin position="123"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS89895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="312" mass="35907" checksum="113185CCF2CC7041" modified="2016-09-07" version="1">MLKFQDNNTTVIATFEDFILTAYVIIDELYHQFAPPEVTRRRHILNAKLSDSEIITISLCGELAGVDSENAWFSFVKRNYRHLFPQLCSRSRFNRTRRALMQTTELLRQKMISVFPIPVSSYYIVDSFPLAVCKFGRARYCKAFRGHGADYGKCPSKKETYYGYKVHALITLEGYIASFEITPASTDDREGLRDLADHWSNVTILADKGYVGKNMKQEMQEKNICLFALKRSNSKENWPKSVRQLIFKLRRRVETVFSQLSGQLNAERVLAKSFQGLCTRLVNKVLAYNLCIALNSIFGETCELGKIKKLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HIX0</accession>
    <name>A0A174HIX0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted HKD family nuclease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Type III restriction enzyme, res subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02989</name>
        <name evidence="2" type="ORF">ERS852478_03788</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000049">
        <property type="protein sequence ID" value="CUO74854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000073">
        <property type="protein sequence ID" value="VUX66713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74854">
        <property type="protein sequence ID" value="CUO74854"/>
        <property type="gene ID" value="ERS852478_03788"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ResIII" evidence="1">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO74854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="96" mass="10962" checksum="56E992599E4C647C" modified="2016-09-07" version="1">MTNSGTGKIYASALAMRELGFKRVLFLVHRVTLAKQAKKSFEKVFDKKVTMGLVGARNARKEDNRGRMQPITKVTMKMHHPVREDLLRYLQSNITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HL28</accession>
    <name>A0A174HL28_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="1">1.1.1.100</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG_5</name>
        <name evidence="1" type="ORF">ERS852478_03792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.100" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000049">
        <property type="protein sequence ID" value="CUO74941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74941">
        <property type="protein sequence ID" value="CUO74941"/>
        <property type="gene ID" value="ERS852478_03792"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO74941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="45" mass="5046" checksum="EF4F4B7E066E80F6" modified="2016-09-07" version="1">MDIANMVLFLCSEKAGFITGENICIDGGMTKQMIYHGDCGWRFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KDF5</accession>
    <name>A0A174KDF5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01151</name>
        <name evidence="2" type="ORF">ERS852523_00472</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP07625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2151"/>
    <dbReference type="EnsemblBacteria" id="CUN81956">
        <property type="protein sequence ID" value="CUN81956"/>
        <property type="gene ID" value="ERS852478_01151"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07625">
        <property type="protein sequence ID" value="CUP07625"/>
        <property type="gene ID" value="ERS852523_00472"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN81956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP07625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="363" mass="41471" checksum="D8B60AA71C7BE4E9" modified="2016-09-07" version="1">MKILVAVLALGLAFWGYAFVYRGKTEPPAKYPVTNQDAAVYSLRGQIQMLSQQEELNTFAFEGRKKEKEYGTYIIPGLRYTRTFLNAEGTKQAVCTSMTPQGLAVTDEYVLVSAYCHTEKHNSVIYVINKETHRFIKEVVLPGLPHVGGLAYDQEHDMLWYSSNTNGIAQAISIKMDVLRDYNYADNHMPVQVNQTCSLYGIVRDSFMTFYKGCLYVGCFNKYTESTIARYAVDSKGDLVNTFNEELGMMFEMAVPLDYSTISEQAQGMAFYNDKLLLSHSFGILPSRIVFYEQSDKRLYVNENSARSYRMPEMIEQIVVEGDELYVLFESGAYAYRGYAGNVVDRVLKLNLIKMEESYQEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KFJ3</accession>
    <name>A0A174KFJ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ppnK</name>
        <name evidence="5" type="synonym">nadK</name>
        <name evidence="6" type="ORF">ERS852478_01168</name>
        <name evidence="7" type="ORF">ERS852523_00489</name>
        <name evidence="8" type="ORF">GT728_00350</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">2789STDY5834863</strain>
            <strain evidence="7 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP08029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704089.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2134"/>
    <dbReference type="EnsemblBacteria" id="CUN82508">
        <property type="protein sequence ID" value="CUN82508"/>
        <property type="gene ID" value="ERS852478_01168"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08029">
        <property type="protein sequence ID" value="CUP08029"/>
        <property type="gene ID" value="ERS852523_00489"/>
    </dbReference>
    <dbReference type="GeneID" id="66494004"/>
    <dbReference type="eggNOG" id="COG0061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="182"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN82508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP08029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL31683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="286" mass="31910" checksum="DC673DE00D86BA9D" modified="2016-09-07" version="1">MDRFYIITNSDKDKKLEITEKIADYLKTHHKNCEVQQAERKHEGSFHYTDPDKVPDDTQCIIVLGGDGTLLQAARDVVHKEIPLLGINLGNLGFLAEVNQTSLYSALDQLMADDYEVEERMMLEGRVYRGRKLIGQDIALNDIVIGRDGHLRVVRFKNYVNDVYLNSYNADGIIISTPTGSTGYSLSAGGPIVSPNAAMTIMTPIAPHTLNTRSIIFPAQDVITVEIGKGRHCDCEKGIASFDGDTFIPMVTGDCIQIRQADVKTKILKLNHLSFVEVLRRKMRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LRQ5</accession>
    <name>A0A174LRQ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02940</name>
        <name evidence="1" type="ORF">ERS852478_03414</name>
        <name evidence="2" type="ORF">ERS852523_01084</name>
        <name evidence="4" type="ORF">GT712_13870</name>
        <name evidence="3" type="ORF">GT728_07790</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUP26783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000014">
        <property type="protein sequence ID" value="MZL33107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000029">
        <property type="protein sequence ID" value="MZS90131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="VUX66664.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_022381125.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63562">
        <property type="protein sequence ID" value="CUO63562"/>
        <property type="gene ID" value="ERS852478_03414"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUP26783"/>
        <property type="gene ID" value="ERS852523_01084"/>
    </dbReference>
    <dbReference type="GeneID" id="66494223"/>
    <dbReference type="eggNOG" id="ENOG5033W6S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="CUO63562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP26783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="106" mass="10326" checksum="432FF1004D16DCB8" modified="2016-09-07" version="1">MSDLAATNCGCEDRGGCGCGCANNSGCGCDNGCGCNNGCGCNSGWGLSGGNNSCCNILWIIILLCLCGNNNCGCSNGCGGCGNGDNCWIIIVLLLLCGNNGCGCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MAJ0</accession>
    <name>A0A174MAJ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rpsQ</name>
        <name evidence="10" type="ORF">BWLFYP14_00264</name>
        <name evidence="6" type="ORF">ERS852478_01666</name>
        <name evidence="7" type="ORF">ERS852523_01286</name>
        <name evidence="9" type="ORF">GT712_08945</name>
        <name evidence="8" type="ORF">GT728_04735</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707264.1">
        <property type="nucleotide sequence ID" value="NZ_WWVL01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2975"/>
    <dbReference type="EnsemblBacteria" id="CUO02891">
        <property type="protein sequence ID" value="CUO02891"/>
        <property type="gene ID" value="ERS852478_01666"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33392">
        <property type="protein sequence ID" value="CUP33392"/>
        <property type="gene ID" value="ERS852523_01286"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO02891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP33392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL32525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX67423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="84" mass="9956" checksum="992B0A776AC11E43" modified="2016-09-07" version="1">MERNLRKTRVGKVVSNKMDKTIVVAIEDHVKHPLYKKIVKRTYKLKAHDENNECNIGDTVKVMETRPLSKDKRWRLVEIVEKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WNS8</accession>
    <name>A0A173WNS8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">16S rRNA (Guanine(966)-N(2))-methyltransferase RsmD</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Ribosomal RNA small subunit methyltransferase D</fullName>
            <ecNumber evidence="3 4">2.1.1.171</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsmD</name>
        <name evidence="6" type="ORF">BWLFYP14_02505</name>
        <name evidence="3" type="ORF">ERS852478_00004</name>
        <name evidence="5" type="ORF">GT712_07880</name>
        <name evidence="4" type="ORF">GT728_12650</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">BIOML-A1</strain>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.171" evidence="3 4"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN40730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000031">
        <property type="protein sequence ID" value="MZL34026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993877.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN40730">
        <property type="protein sequence ID" value="CUN40730"/>
        <property type="gene ID" value="ERS852478_00004"/>
    </dbReference>
    <dbReference type="GeneID" id="66492927"/>
    <dbReference type="eggNOG" id="COG0742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052913">
        <property type="term" value="F:16S rRNA (guanine(966)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN40730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="183" mass="20691" checksum="7A3C62C94B65E178" modified="2016-09-07" version="1">MRVIAGKARRLNLKTIPGIDTRPTTDRIKETLFNILQPELLECRFLDLFSGSGGIGIEALSRGASYAVFVEKNPKAAACIRENLAFTKLAEDGKLLNMDVLQALRSLEGKGVFDIIFMDPPYNNELERQVLEYLKDSTVADKNTLIIVEADLQTDFSYVESLGYRQLRSKEYKTNKHVFLERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WQV4</accession>
    <name>A0A173WQV4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anaerobic sulfite reductase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_00041</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380683.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41893">
        <property type="protein sequence ID" value="CUN41893"/>
        <property type="gene ID" value="ERS852478_00041"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17179">
        <property type="entry name" value="Fer4_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN41893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="343" mass="38929" checksum="60B3314BEEC47C8D" modified="2016-09-07" version="1">MYKIAAENLQALFQKIAADQDLYLPVKVSDQVNFRAWSQDAEVCLDTLKTVKSPKDAFFPQSENLYTCEKEGKNITIEPQALQEKNFVVFGMKACDVQGVKVLDNVFLSDPVDTFYAARREHGTIVALACHEPEESCFCKVFGIDCADPVADVAAWMIEGELYWKPLTEKGEALTKAVAELLNDADEAKVEEEKTAIRAIVEKLPYSNLSLEGWGQEDYMDRFNSPVWEELYKPCLACGTCTFVCPTCQCYDIKDYDTGHGVQRYRCWDSCMYSDFTMMAHGNNRNSQMQRFRQRFMHKLVYYPVNNNGMFSCVGCGRCVEKCPSSLNIVKVIKAFENQGGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WSA9</accession>
    <name>A0A173WSA9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="5">IGPD</shortName>
            <ecNumber evidence="5 6">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">hisB</name>
        <name evidence="7" type="ORF">ERS852478_00018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="5 6"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199468.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41235">
        <property type="protein sequence ID" value="CUN41235"/>
        <property type="gene ID" value="ERS852478_00018"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN41235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="195" mass="21519" checksum="8DCA2918A79FE22C" modified="2016-09-07" version="1">MAREASAERNTKETEIKLKINLDGTGYSDIETGVGFFNHMLDGFTRHGLFDLSVRVHGDLQVDDHHTIEDTGIVLGTALKEAIGDKKGIKRYGSCILPMDESLVLCAIDLSGRPYFVWDAEFTTDRIGDMSTEMVKEFFYAISYACGMNLHIRVLAGGNNHHVAEAMFKSFAKALDAATSYDTRITDVLSTKGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WYU7</accession>
    <name>A0A173WYU7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rod shape-determining protein MreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852478_00134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MreD family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199504.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000070.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44643">
        <property type="protein sequence ID" value="CUN44643"/>
        <property type="gene ID" value="ERS852478_00134"/>
    </dbReference>
    <dbReference type="GeneID" id="66495890"/>
    <dbReference type="eggNOG" id="COG2891">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017225">
        <property type="entry name" value="Cell_shape_determin_MreD_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04093">
        <property type="entry name" value="MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037497">
        <property type="entry name" value="MreD_Clostridium/Treponema_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03426">
        <property type="entry name" value="shape_MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN44643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="176" mass="20259" checksum="657FB5D280045E89" modified="2016-09-07" version="1">MKSKIALFFMILISFLLQCTLLHVISIGSITPNLILILCISMGLMRGRKSGLWTGFFCGFLVDMFYGSVFGFYALIYMYIGFLSGYAHRICYDDDIKVPVMLAGIGDLLYGLSVYALQFLLRGRLGLGTYLYRIILPEIFYTVILTLIVYRVFHYINYHFMNNPSMKESESIWVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X357</accession>
    <name>A0A173X357_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxybenzoyl-CoA reductase subunit alpha</fullName>
            <ecNumber evidence="2">1.3.7.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hcrA_1</name>
        <name evidence="2" type="ORF">ERS852478_00196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.7.9" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199508.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46222">
        <property type="protein sequence ID" value="CUN46222"/>
        <property type="gene ID" value="ERS852478_00196"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="16"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN46222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="757" mass="83151" checksum="DF457213CCBCCB2C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X8C6</accession>
    <name>A0A173X8C6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="6">HAT</shortName>
            <ecNumber evidence="6">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Homoserine transacetylase</fullName>
            <shortName evidence="6">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">metA</name>
        <name evidence="6" type="synonym">metAA</name>
        <name evidence="11" type="ORF">BWLFYP14_02725</name>
        <name evidence="8" type="ORF">ERS852478_00229</name>
        <name evidence="10" type="ORF">GT712_00320</name>
        <name evidence="9" type="ORF">GT728_05845</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 15">BIOML-A1</strain>
            <strain evidence="10 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MetA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN47147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381035.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN47147">
        <property type="protein sequence ID" value="CUN47147"/>
        <property type="gene ID" value="ERS852478_00229"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008899">
        <property type="term" value="F:homoserine O-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019281">
        <property type="term" value="P:L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03131">
        <property type="entry name" value="GATase1_HTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00295">
        <property type="entry name" value="MetA_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005697">
        <property type="entry name" value="HST_MetA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033752">
        <property type="entry name" value="MetA_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20919">
        <property type="entry name" value="PTHR20919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04204">
        <property type="entry name" value="HTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000450">
        <property type="entry name" value="H_ser_succinyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01001">
        <property type="entry name" value="metA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6 7">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for acyl-CoA specificity" evidence="6">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="6">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000450-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN47147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL32740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS87571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX66352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="310" mass="36336" checksum="676A31E3D493D58C" modified="2016-09-07" version="1">MPIKIQSDLPVKEILEKENIFVMDESRASHQDIRPIQILILNLMPLKEETELQLLRSLSNTPLQVDVTFMAVQSHEAKNTSVSHLNKFYQTFPELKNNKYDGMIITGAPVEQMEFEEVDYWKELVEIMDWTNTHVTSTIYLCWAAQAGLYHHYGLKKRKLDKKMFGLFWHKVMNRKIPLVRGFDDMFLAPHSRHTEVPIEDIHNCKELTVLAESDEAGLFLAMADGGRKIFVMGHPEYDRVTLDGEYKRDVSKNLPIEIPENYYKDNNPENRPLLMWRAHANNLYTNWLNYYVYQSTPFDLYGTPDFSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XH87</accession>
    <name>A0A173XH87_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylornithine aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.11</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Acetylornithine/succinylornithine family transaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">argD_1</name>
        <name evidence="6" type="ORF">BWLFYP14_01944</name>
        <name evidence="4" type="ORF">ERS852478_00327</name>
        <name evidence="5" type="ORF">GT712_05815</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000009">
        <property type="protein sequence ID" value="MZS88615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706795.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51181">
        <property type="protein sequence ID" value="CUN51181"/>
        <property type="gene ID" value="ERS852478_00327"/>
    </dbReference>
    <dbReference type="GeneID" id="66495958"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN51181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="405" mass="44248" checksum="4CC78F9230F9AD50" modified="2016-09-07" version="1">MKLKDTGLTFQDIKDKVNKYMIETYERFDFLAETAEGMYIYDENKTPYLDFYAGIAVNSAGNCNPKVVAAAKDQLDDIMHTFNYPYTIPQALLAEKVCETIGMDKIFYQNSGTEANEAMIKMARKYGIEKYGPNRYHIVTAKMGFHGRTFGAMSATGQPGNGCQVGFGPMTYGFSYAPYNDLQAFKDACTENTIAIMVEPVQGEGGVHPATMEFMQGLRKFCDENDMLLLIDEVQTGWCRTGAVMSYMNYGIKPDIVSMAKALGGGMPIGAICATAEVAKAFTAGSHGTTFGGHPVSCAAALAEVNELLDRDLAGNAKKVGDYFAAKLEKLPHVKEVRHQGLLVGVEFDDTIGGVDVKHGCLDRHLLITAIGAHIIRMIPPLIVTEEECDKAVAIIEDTIKSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XMZ9</accession>
    <name>A0A173XMZ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Na(+)/drug antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">norM_1</name>
        <name evidence="2" type="ORF">ERS852478_00394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199599.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53252">
        <property type="protein sequence ID" value="CUN53252"/>
        <property type="gene ID" value="ERS852478_00394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN53252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="443" mass="47815" checksum="76E7ECDB9AE5CC81" modified="2016-09-07" version="1">MSKFMKSLCKIAIPVTLQSMLQASFSIVDQIMIGQLGETNISAVGLCGNFSLIFSVVIGAVSTVAGILIAQFIGAQETKEAWCSFDVSFICGIIISALFLLAAGVFPSQILGLYTKDMSIINTGAVYFRIIAFSYIPMAVSNILSSWLRCKEYATIPFLASFGAIIVNTGLNYLLIFGKLGFSCMGITGAAIATLISQLFNLIFIVIGFVLCIRKDGDKPVLSLHFKKITIRDYLIMIMPILISEFLWSLGQNVESAVYGHLGTSSLAAYTLTGPIQGLMVGALSGLSAAAGVIVGKRLGRKEYDEAYTESKKIMYAGLFGAVMVSALLILLAGAYTGLYRVDDSVKDLGKTLLIVFALYAPVKVENMILGGGIIRSGGNTKIIMIIDIVGTWCIGIPLCLLAAYVFKWGIVGVYTLLTTEELFRLAVSLIVFKRRKWIISLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y138</accession>
    <name>A0A173Y138_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-fucose isomerase and related proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57599">
        <property type="protein sequence ID" value="CUN57599"/>
        <property type="gene ID" value="ERS852478_00505"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008736">
        <property type="term" value="F:L-fucose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015888">
        <property type="entry name" value="Fuc_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02952">
        <property type="entry name" value="Fucose_iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucose_iso_C" evidence="2">
        <location>
            <begin position="352"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN57599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="495" mass="54981" checksum="5F456FAF7BD09795" modified="2016-09-07" version="1">MIDNMPKVKVGIVAVSRDCFPESLSVNRRKALVEAYTKKYGAEDIYECPICIVESEIHMVQALEDIKKAGCNALCVYLGNFGPEISETLLAKHFEGPKMFCAAAEETQGDLIQGRGDAYCGMLNASYNLQLRNVKAYIPEYPVGDAEDCADMIHDFLPIARAVEGLSNLKIISFGPRPTNFLACNAPIKQLYNLGVEIEENSELDLFEAFNKHAGDERIPAVVKEMEEELGAGNKKPEILEKLAQYELTLKDWVEAHRGYRKYVTLTGKCWPAFQTQFGFVPCYVNSRLTAQGIPVSCEVDIYGTLSEFIGTVVSQDTVTLLDINNSVPKDMYKESIEGKYNYTLKDTFMGFHCGNTASSKLSFCEMKNQMIMARSLPVEVTNGTLEGDIVPGDITFYRLQSTADNKLRGYIAHGEVLPVATKSFGSIGVFAIPEMGRFYRHVLIEGGYPHHGAVAFGHYGKALFEVFKYIGVPVEEIGYNQPAGVRYPTENPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y1F3</accession>
    <name>A0A173Y1F3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fimbrial isopeptide formation D2 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_00517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58042">
        <property type="protein sequence ID" value="CUN58042"/>
        <property type="gene ID" value="ERS852478_00517"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026466">
        <property type="entry name" value="Fim_isopep_form_D2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01451">
        <property type="entry name" value="B_ant_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04226">
        <property type="entry name" value="RrgB_K2N_iso_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015837" evidence="3">
        <location>
            <begin position="37"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1534"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="4">
        <location>
            <begin position="513"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1416"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1429"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1483"/>
            <end position="1500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN58042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1569" mass="171874" checksum="DA2EEF8647AD0E4B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y293</accession>
    <name>A0A173Y293_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal RNA large subunit methyltransferase L</fullName>
            <ecNumber evidence="4">2.1.1.173</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rlmL_1</name>
        <name evidence="4" type="ORF">ERS852478_00525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.173" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059933.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58302">
        <property type="protein sequence ID" value="CUN58302"/>
        <property type="gene ID" value="ERS852478_00525"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052915">
        <property type="term" value="F:23S rRNA (guanine(2445)-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01261">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="45"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN58302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="383" mass="43816" checksum="F16EFC2CF0C43131" modified="2016-09-07" version="1">MEKFELIAPCHFGMEAVLKREILDLGYEITKVEDGKVTFEADAQGIADANIFLRSTERILLKVAEVKAETFDELFEKTKALPWENYIPKDGKFWVAKANSVKSKLFSPSDIQSIMKKAIVERLKGVYGVSWFEEDGASFPIRVAFMKDVATIGIDTSGVSLHKRGYRKMTVKAPITETLASALIMLTPWNKDRILVDPFCGSGTFPIEAAMMAADIAPGMNRSFLAEEWKHLVPRKCWYDANEEAQDRINLNIETDIQGFDIDPEALKAARANAKMAGVDKLIHFQQRAVKDLRHPKPYGFIITNPPYGERLEEKENLTQLYREIGESYERLDKWSMYLITSYEKAENDIGRKADKNRKIYNGMLKTYYYQFLGPRPPKKNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y900</accession>
    <name>A0A173Y900_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Germination protease</fullName>
            <ecNumber evidence="1">3.4.24.78</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GPR endopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Germination proteinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Spore protease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">gpr</name>
        <name evidence="2" type="ORF">ERS852478_00599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Initiates the rapid degradation of small, acid-soluble proteins during spore germination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endopeptidase action with P4 Glu or Asp, P1 preferably Glu &gt; Asp, P1' hydrophobic and P2' Ala.</text>
            <dbReference type="EC" id="3.4.24.78"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Autoproteolytically processed. The inactive tetrameric zymogen termed p46 autoprocesses to a smaller form termed p41, which is active only during spore germination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A25 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.78" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199718.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60602">
        <property type="protein sequence ID" value="CUN60602"/>
        <property type="gene ID" value="ERS852478_00599"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00626">
        <property type="entry name" value="Germination_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005080">
        <property type="entry name" value="Peptidase_A25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03418">
        <property type="entry name" value="Peptidase_A25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019549">
        <property type="entry name" value="Peptidase_A25"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01441">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5008186496" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023436405" description="Germination protease" evidence="1">
        <location>
            <begin position="11"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN60602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="304" mass="33561" checksum="99E19C6DA11D20C5" modified="2016-09-07" version="1">MLDNYGIRTDLALEATERFTEENVEVRGVEVHEDYNEEKDIRTTVVKITTENGARTMGRPQGSYITIEAPGLSVHDEDYHREISLEIARHLQNVINLERELSILVVGLGNSAITADSLGPHVVENLHITRHMIREYGLQSLGKEKMHRISGIIPGVMAQTGMETSEIIQGIVAETKPDIVIAIDALAARSTRRLNRTIQITDTGINPGSGVGNHRVGLTEENLQVKVIGIGVPTVVDAATIVHDSMAHLLEALEEAEQKEFLEEMISPHLHTMFVTPKDVDETVKYLSFTISEGLNMAFEEIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y964</accession>
    <name>A0A173Y964_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron hydrogenase 1</fullName>
            <ecNumber evidence="8">1.12.7.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_00575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.12.7.2" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053034.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59777">
        <property type="protein sequence ID" value="CUN59777"/>
        <property type="gene ID" value="ERS852478_00575"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S" evidence="7">
        <location>
            <begin position="353"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN59777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="574" mass="64830" checksum="8FDF733918939CDD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YAG9</accession>
    <name>A0A173YAG9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Holin family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Phage-related holin (Lysis protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BWLFYP14_03270</name>
        <name evidence="6" type="ORF">ERS852478_00586</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX66993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60136">
        <property type="protein sequence ID" value="CUN60136"/>
        <property type="gene ID" value="ERS852478_00586"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006480">
        <property type="entry name" value="Phage_holin_4_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05105">
        <property type="entry name" value="Phage_holin_4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN60136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="74" mass="7998" checksum="60E988C229FA48AE" modified="2016-09-07" version="1">MKYRIITLIGLAGSTLAVCLGGWDKFLQTLLLFMAIDWFTGGILLPAVFGKSPKSENGVHWKAEQVGKGCAEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YE03</accession>
    <name>A0A173YE03_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Teichoic acids export ATP-binding protein TagH</fullName>
            <ecNumber evidence="6">3.6.3.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tagH_1</name>
        <name evidence="6" type="ORF">ERS852478_00624</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.40" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61457">
        <property type="protein sequence ID" value="CUN61457"/>
        <property type="gene ID" value="ERS852478_00624"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10147">
        <property type="entry name" value="Wzt_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029439">
        <property type="entry name" value="Wzt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14524">
        <property type="entry name" value="Wzt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN61457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="426" mass="47773" checksum="46F5A706A3B4540D" modified="2016-09-07" version="1">MENKKVIQVKDLTKMYKLYDKPSDRLKEALGLTRKKLYKEHYALHDVNFDIYEGECVGIIGTNGSGKSTILKIITGVLTPTAGEVKVDGRISALLELGAGFNMEYSGLENVYLNGTMIGFSKEEIDARLNDILEFADIGDFIHQPVKTYSSGMFVRLAFAVAINIDPEILVVDEALSVGDVFFQAKCYHKFEEFKKQGKTILFVSHDLGSVSKYCDRVILLNKGVKMDEGSPKQMVDLYKQLLVGQNPVKQNESDGTEQIVAEDSEGLGDFQVNPNMLEYGSRIAEITDFRVIDDKGRCSNTVEKGSCFKIRMKVRFNEEIQEPIMAYTFKNIQGTEITGTNTMYENAKIEHSGKGDICTVTFTQNMNLQGGEYLLSFGCTGYKNGDFTVFHRLYDACNITVISSKNTVGFYDMDSKVEVRCEEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YK75</accession>
    <name>A0A173YK75_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ypdA_2</name>
        <name evidence="10" type="ORF">ERS852478_00684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059352.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64512">
        <property type="protein sequence ID" value="CUN64512"/>
        <property type="gene ID" value="ERS852478_00684"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="206"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="311"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN64512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="493" mass="56733" checksum="1A3961C87BB1FEB1" modified="2016-09-07" version="1">MKQLRWKDFSLVSKIVIEVGMIAVLLFAMNMLFYVRINNSMQKMDNVYASNAELTELSQVFEKVQDNMYKYLKVKNSQTLLDYYQNEAKYRNELEKLNEDNINDPVKLLERNIRKMSETYLDCTAETVAAKRGRNVEQYKRKYDDATKLYRYIQSSIDELNNLMFQENSSTYAVLRAVMRYLEISNSVIMIIIVAGGMLLLIQATRNMFVPLSNMAETAQLVGQGNFHVKMHDTDAQDELGTVTRAFNTMVENLDLYMARTKASMEKEQQMMERELLMENHLKEAQLKYLQSQINPHFLFNSLNAGAQLAMMEDAEQTGIFVEKMADFFRYNVKKGQEDATLGEELEAVDNYIYILNVRFAGDIHFSKEVDESLENVRMPSMILQPVVENAVNHGIRDIEWEGKIHLTVTGDADYIRISVKDNGKGMTQEQIEGVLSGNRERRNEEGDSTGIGMNNVISRLELYYEESGLMEINSEGEGKGTEAVIYIPVHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YPQ6</accession>
    <name>A0A173YPQ6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15 16">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="6 15 16">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 19" type="primary">murD</name>
        <name evidence="19" type="ORF">ERS852478_00705</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 15 16">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 15 16">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="6 15 16"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199768.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN65186">
        <property type="protein sequence ID" value="CUN65186"/>
        <property type="gene ID" value="ERS852478_00705"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 15 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 15 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 15 16" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 15 16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="18">
        <location>
            <begin position="114"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="17">
        <location>
            <begin position="312"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="116"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CUN65186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="451" mass="49871" checksum="1647E366EA3C7202" modified="2016-09-07" version="1">MELQGKKVLVFGSGKSGIGASDLLAKVGAFPVIYDGNAETDKDAVVHKTDGTYPVTVYAGELPKEVQDSLDLVVLSPGVPTDLPLVKSFYEQGLPVWGEVELAYRVGDGEVLAITGTNGKTTTTALLGKIMQDARESVFVVGNIGTPYTSKVLEMKPNSITVAEISSFQLETIDEFAPKVSAILNITEDHLNRHHTMEEYIRVKELITENQGTEDVCVLNYEDEVLREFGKHLTPRVVYFSSGRKLDEGIYLDGNKIILKDGEKEIEVVKTEDLKLLGKHNFENVMAAVAMAYYDGVSLDSIRKSICEFTAVAHRIEYVTEKKGVVYYNDSKGTNPDAAIKGIQAMNRPTLLIGGGYDKQSGYDEWIEAFDGKVRYLVLIGQTKEKIKEAAEKHGFHDIILCEDLKEAVKVCEEKAQPGDAVLLSPACASWGQFDNYEQRGDMFKEYVRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YR81</accession>
    <name>A0A173YR81_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_01782</name>
        <name evidence="5" type="ORF">ERS852478_00739</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993621.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66404">
        <property type="protein sequence ID" value="CUN66404"/>
        <property type="gene ID" value="ERS852478_00739"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033QJ9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01451">
        <property type="entry name" value="B_ant_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252792" evidence="3">
        <location>
            <begin position="30"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="4">
        <location>
            <begin position="415"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN66404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX64990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="603" mass="66608" checksum="EED7447AF32A12BD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YXS0</accession>
    <name>A0A173YXS0_9FIRM</name>
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        <submittedName>
            <fullName evidence="6">Sulfite reductase, dissimilatory-type subunit alpha</fullName>
            <ecNumber evidence="6">1.8.99.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dsvA</name>
        <name evidence="6" type="ORF">ERS852478_00803</name>
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        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.99.3" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199805.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68774">
        <property type="protein sequence ID" value="CUN68774"/>
        <property type="gene ID" value="ERS852478_00803"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018551">
        <property type="term" value="F:hydrogensulfite reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN68774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="303" mass="33683" checksum="868B175E06E8BE23" modified="2016-09-07" version="1">MNEEKITTSANKKLSPEEIKRVKGLGCLQDKRYDDIFNIRVITGNGHITTDEHRAIADAADKFGNGQITMTTRLSMEIQGVPYDNIEKTIAFLGEHGLMTGGTGAKVRPVVSCKGTTCQYGLIDTFALSKKIHERFYVGYHDVVLPHKFKIAVGGCPNNCVKPNLNDMGIIGQRIPKPDSEKCRGCKKCQIEKSCPVHVPKLVDGKLYIDPEECIHCGRCKGKCPFGAVPEYQNGYKIYIGGRWGKRVSHGQALTRIFTEEEEVMAVIEKAILLFKNEGIAGERFADTVKRLGFEYVNEKLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YZR6</accession>
    <name>A0A173YZR6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bioY_1</name>
        <name evidence="5" type="synonym">bioY_2</name>
        <name evidence="4" type="ORF">ERS852478_00812</name>
        <name evidence="5" type="ORF">ERS852523_03005</name>
        <name evidence="6" type="ORF">GT728_12460</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
            <strain evidence="5 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000037">
        <property type="protein sequence ID" value="CUP84394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000030">
        <property type="protein sequence ID" value="MZL33992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058206.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000038_gene3335"/>
    <dbReference type="EnsemblBacteria" id="CUN69019">
        <property type="protein sequence ID" value="CUN69019"/>
        <property type="gene ID" value="ERS852478_00812"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP84394">
        <property type="protein sequence ID" value="CUP84394"/>
        <property type="gene ID" value="ERS852523_03005"/>
    </dbReference>
    <dbReference type="GeneID" id="66493607"/>
    <dbReference type="eggNOG" id="COG1268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN69019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP84394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL33992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="194" mass="20383" checksum="DF980BDDB383A062" modified="2016-09-07" version="1">MSQSYAKSPAAERKFTTREMVLVGMFAAVLAVISQISLPMPTGVPITIQVFGVALVGAVLGSRLGTTATLVYVLLGAIGLPIFANFSGGISSIVGVTGGYIWAWPIMTWLCGIRPKTENKTKNLAISIVFALIGLLIVETIGGLQWHFVGGSMSIPAIAVYSLTAFIPKDIVITVLAVLIAIPIRKGINNAGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z6E2</accession>
    <name>A0A173Z6E2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Na(+)/drug antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">norM_3</name>
        <name evidence="2" type="ORF">ERS852478_00857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380097.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71363">
        <property type="protein sequence ID" value="CUN71363"/>
        <property type="gene ID" value="ERS852478_00857"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN71363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="455" mass="49855" checksum="0205E954976E0516" modified="2016-09-07" version="1">MKKDTTNDMTVGSPVSLIIKFMIPMCLGNLFQQFYNIADSIVAGKFIGVNALAAIGSTGSLMFFVTGWLNGLSSGFAIIVAQMFGAKKFDRMRHYVAMSIYLMAAFSIVMTIGFSLANKPILHLMNSPEEVFGDVTAYMGIIYAGLIITGAYNALAAFLRALGDSKSPLYFLIISAVINVILDVVFIVVFGMGVEGCGYATVIAQGISAVCCLIYIVKRFPILHLERKDFEICWDSFGRLLKLGIPMGLQFSITAIGTIIVQSAVNIYGPVHMAGFSAAGKIQNIFATVFTAFGATIATYVGQNRGAGKMDRVKQGVRYTQMMVLGWSVFVMFLMFFFGKYLTYLFVDPSEQDVVNVSVTYFRTVFWAYPFLGSIFLYRNTLQGMGYGLVPMLGGVFELVARTGIVVLIAGHTSFAGVCMADPTAWIAALIPLIPYYFHVMKKYKNKSQVQAVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZD22</accession>
    <name>A0A173ZD22_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpB_1</name>
        <name evidence="11" type="synonym">atpB</name>
        <name evidence="13" type="ORF">ERS852478_00917</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199842.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73098">
        <property type="protein sequence ID" value="CUN73098"/>
        <property type="gene ID" value="ERS852478_00917"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN73098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="220" mass="24509" checksum="AB3929865CE61630" modified="2016-09-07" version="1">MEELQCKTVFTIPVFGGIPVAESVAVTWVIMAVLLILSLVLVRNLSVENPGKKQILLETGVSFLHDFFKDILGEEGKMYIPYLMTVVIYIGIANIFGVFGFVPPTKDLNCTIGLALTSIFLIEYAGFHKKGLKGFLKSFAEPAPIMLPINILEVAIRPTSLCMRLFGNVLGSYVVMKLLEFICPAIIPIPFSLYFDFFDGFIQAYVFVFLTSLFIKEAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZEY4</accession>
    <name>A0A173ZEY4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thiazole synthase</fullName>
            <ecNumber evidence="4 6">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">thiG</name>
        <name evidence="11" type="ORF">BWLFYP14_01328</name>
        <name evidence="8" type="ORF">ERS852478_00958</name>
        <name evidence="10" type="ORF">GT712_16950</name>
        <name evidence="9" type="ORF">GT728_01465</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 15">BIOML-A1</strain>
            <strain evidence="10 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiG family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4 6"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000047">
        <property type="protein sequence ID" value="MZS90700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707074.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74333">
        <property type="protein sequence ID" value="CUN74333"/>
        <property type="gene ID" value="ERS852478_00958"/>
    </dbReference>
    <dbReference type="GeneID" id="66493258"/>
    <dbReference type="eggNOG" id="COG2022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ThiG" evidence="7">
        <location>
            <begin position="11"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="DXP binding" evidence="6">
        <location>
            <begin position="208"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="6">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN74333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL31901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS90700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX64289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="259" mass="27576" checksum="A12881EE0853B8BA" modified="2016-09-07" version="1">MSTNNEDKLILGGHEFTSRFILGSGKFSLDLVKACIEKADAQIITLALRRANEGGLANILDYIPKNVTLLPNTSGARNAEEAVRIARLSREIGCGDFVKIEVIHDSKYLLPDNYETVKATEILAKEGFVVMPYMYPDLNAARDLVNAGAACIMPLGSPIGSNKGLCTKEFIQILIDEIELPIIVDAGIGRPSQACEAMEMGASAVMANTAIATAGDVQIMAEAFKKAIEAGRSAYLAGLGRTLEKGASASSPLTGFLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZG19</accession>
    <name>A0A173ZG19_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type uncharacterized transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199855.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74580">
        <property type="protein sequence ID" value="CUN74580"/>
        <property type="gene ID" value="ERS852478_00966"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016846" evidence="1">
        <location>
            <begin position="17"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN74580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="68" mass="7473" checksum="515E655DCB533129" modified="2016-09-07" version="1">MNIKKILKPVLSIVLALVLGAAVIAMVGENPLSVYRSMLLGAFGSKMSIQKDSCWKPARIIWSLQMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZG35</accession>
    <name>A0A173ZG35_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-N-arabinofuranosidase</fullName>
            <ecNumber evidence="5">3.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">abfA_1</name>
        <name evidence="5" type="ORF">ERS852478_00985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199872.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75201">
        <property type="protein sequence ID" value="CUN75201"/>
        <property type="gene ID" value="ERS852478_00985"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="4">
        <location>
            <begin position="292"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN75201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="507" mass="57543" checksum="38DA9B4FE6EFDA3A" modified="2016-09-07" version="1">MAKQAKMVVDKAFSISKIDKRIYGSFIEHLGRAVYDGIYQPGHPLSNADGFRKDVIDLVKELDVPIVRYPGGNFVSNFYWEDSVGPVEERPHRLELAWRSLEKNEVGLHEFKKWADAANSEVMMAVNLGTRGITDACNLLEYCNHPGGTKYSDLRIKHGQKDPYGFKTWCLGNEMDGPWQIGHKTMDEYGRLAEETAKAMKLIDPSIEFVVCGSSNQEMPTFALWEDHVLSHTYDYVDYLSLHTYYGNRSDDSNDFLAKSDDMDEFIRTIIATCDYVKAKKRSKKNMYLSFDEWNVWYHSNAADNDITENHPWQVAPPLLEDIYNFEDALLVGLMLIVLIRHSDRVKVACLAQLINVIAPIMTDPNGGGSWKQTIFYPFMHASKYGRGVALQPVISSTEHETSGHGSITDIEAVAVYNEEKEEVTIFAVNRNLKEDVVLNTDVRSFEGYRVAGHIVLESDDLKVVNAFGQENVKPKTTEQTTMDNGELTSMLHKASWNVIRLVKDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZHW7</accession>
    <name>A0A173ZHW7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199860.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74725">
        <property type="protein sequence ID" value="CUN74725"/>
        <property type="gene ID" value="ERS852478_00972"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN74725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="480" mass="55485" checksum="516CEAFC85C20507" modified="2016-09-07" version="1">MKTFLSADRRFLNPQAMENVELKAAVPAKDTENNPLFTQDMPWEIRIDNGYPNVIYDRREQIFHCYYTLFTEDKDTEGTTLQERTQRNYRPRMDRVTSLAYARSKDGIHWEKPSLGLVDWRGSKENNLLFRYAHGTGVMLDERDKNAGRRFKMVTKVDIPGHGAHMAVGFSEDGIHWGELIPWPEYNPQADSHNFPFWNEEEQCYMLVSRIWKDGIRVTTISHSQDFIHWSEPVETLRGRGYENQIYSMPVFKTHGLYLGLASLLHEGDRNEKNFDCVDCELTWSADGKKFDFAAMDQAVIPRGDGHYPDGEFDNSCIYASSPVTDGQKVWIYYMGGNGQHTNFRESSLGRAYWEADKFACWTEKNEGMESILTTTTLTLGGNYIEVLADEADAEKDWELMASVHPVWTENAYEGLGMEDAVTEKSGRWIRISWKGKKLPDKSGCIRFQFKNLKIWAVRGELEYKGHRLWEGADMENEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZQ98</accession>
    <name>A0A173ZQ98_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">L(+)-tartrate dehydratase subunit alpha</fullName>
            <ecNumber evidence="8">4.2.1.32</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ttdA_2</name>
        <name evidence="9" type="synonym">ttdA_1</name>
        <name evidence="9" type="ORF">BWLFYP14_00337</name>
        <name evidence="8" type="ORF">ERS852478_01057</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.32" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052528.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000144.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78592">
        <property type="protein sequence ID" value="CUN78592"/>
        <property type="gene ID" value="ERS852478_01057"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008730">
        <property type="term" value="F:L(+)-tartrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN78592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX67492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="301" mass="32406" checksum="DE06004B7435B543" modified="2016-09-07" version="1">MTKENGVKVLTDMVADFVAHIGKKLPDDVVEKLEELGSQESAALPKVLYETMTKNQGLAVELNRPSCQDTGVLQFWLKCGTNFPYINELEALLKEAVVQATFAAPLRHNSVETFDEYNTKKNVGKGTPTVWWDIVPNSDKCEIYAYMAGGGCTLPGKAMVLMPGAGYEGITDFVLDQMTTYGLNACPPLLVGVGVGTSVETAALNSKKALMRPIGSHNDNANAAKMEKLLEDGINAIGLGPQGMGGKYSVMGVNIENTARHPSTIGVAVNVGCWSHRRGHLIVNSDLTVTCDTHSTWKFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZZQ2</accession>
    <name>A0A173ZZQ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spore coat associated protein CotJA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Spore coat associated protein JA (CotJA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_03100</name>
        <name evidence="1" type="ORF">ERS852478_01134</name>
        <name evidence="2" type="ORF">GT712_03435</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994075.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000108.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81373">
        <property type="protein sequence ID" value="CUN81373"/>
        <property type="gene ID" value="ERS852478_01134"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033B4S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020256">
        <property type="entry name" value="Spore_coat_CotJA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11007">
        <property type="entry name" value="CotJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN81373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS88164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="107" mass="12281" checksum="3CD238BF3F3A33A0" modified="2016-09-07" version="1">MENYRMGCSGNRPYNRTCGMNMPQPSNRNMNSSECSVRNTTDCSCTIPGVKEKKHKMFSHLQYLEPAMAYVPCQKFTENFPLQYALNVGTIFPQLCKPFCGKRGIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A0E6</accession>
    <name>A0A174A0E6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Resolvase, N terminal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852478_01120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199928.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80878">
        <property type="protein sequence ID" value="CUN80878"/>
        <property type="gene ID" value="ERS852478_01120"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="7">
        <location>
            <begin position="5"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="8">
        <location>
            <begin position="160"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="350"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4 5">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN80878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="471" mass="53973" checksum="F5FE32EA21791B3C" modified="2016-09-07" version="1">MSSKVACLYIRVSTEDQTELSPDAQKRLLLDYAQKNDMIVSGDFIFTESVSGRHAQKRPEFQKMIALAKQPSHPIDVILVWKFSRFARNQEESIVYKSMLKKDNVDVISVSEPLIEGPFGSLIERIIEWMDEYYSIRLSGEVLRGMKEKALQKGYQTSPCLGYTAVGHGKPYIINEAEYAIVSYIMDLYDNQNLDETAIARRCNDLGYRTKRGKLFERRSVDRILGNPFYCGTVVWNGVEFEGSHEVRLSRERYEKRQKLIASRKRPVKARNVSACKHWLSGLLKCSVCGATLSYTGNNKCPYFQCWKYAKGFHKTSVALSVKKAEEAVISYFDQILDGAEFTYVCKKKKTDHSLQIDQLQREISKLAMREGRIKEAYEAGVDTLEEYKNNKDRLVSDRLELTAALSQLLQEEQAEQPDTEKILKEIRSVADVLKNPDVGYEEKGNLIRSVVEQIIYDKESGKMSFDIIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A0Y7</accession>
    <name>A0A174A0Y7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome segregation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199935.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81509">
        <property type="protein sequence ID" value="CUN81509"/>
        <property type="gene ID" value="ERS852478_01138"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017331" evidence="2">
        <location>
            <begin position="29"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN81509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1004" mass="104199" checksum="F85145B71E7B557B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A1V2</accession>
    <name>A0A174A1V2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein YdfJ</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Putative membrane protein ydgH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ydgH</name>
        <name evidence="9" type="synonym">ydfJ</name>
        <name evidence="9" type="ORF">BWLFYP14_03097</name>
        <name evidence="8" type="ORF">ERS852478_01137</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199934.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81475">
        <property type="protein sequence ID" value="CUN81475"/>
        <property type="gene ID" value="ERS852478_01137"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
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        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="662"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="114"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="388"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN81475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="696" mass="76709" checksum="2116F0C5621C54D1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A7X3</accession>
    <name>A0A174A7X3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chondroitin polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">kfoC_2</name>
        <name evidence="2" type="ORF">ERS852478_01202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199958.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83870">
        <property type="protein sequence ID" value="CUN83870"/>
        <property type="gene ID" value="ERS852478_01202"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN83870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="338" mass="39428" checksum="776CFC9F5610F6FF" modified="2016-09-07" version="1">MKLLSIAIPCYNSQDYMENCIESLLVGGEEVEILIVDDGSSDRTAEIADDYARKYPTIVKAIHQENGGHGEAVNAGIRNATGLYFKVVDSDDWVNKEAYVQILKTLYELLRGPQTVDLLISNFVYEKQGATRKKIMQYRKCLPQDRIFGWEEVKHMPKGKYLLMHSMIYRTKLLHECNLELPKHTFYVDNLFAFEPLPYVKNLYYLDVNFYRYFIGRDDQSVNEKVMIKRIDQQIRVNKLMVDAYINCKSTNKQLKAYMFSYLDIITTISSIMLIRANTGESLQKKKELLEYIRTENKQVYRKLRHSLFGRVMNLPGRGGRKMSVAAYKISQKFYGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A919</accession>
    <name>A0A174A919_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA topoisomerase 3</fullName>
            <ecNumber evidence="6">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA topoisomerase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">topB_1</name>
        <name evidence="6" type="synonym">topB</name>
        <name evidence="9" type="ORF">ERS852478_01205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199960.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83965">
        <property type="protein sequence ID" value="CUN83965"/>
        <property type="gene ID" value="ERS852478_01205"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00953">
        <property type="entry name" value="Topoisom_3_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005738">
        <property type="entry name" value="TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01056">
        <property type="entry name" value="topB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="2"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="6">
        <location>
            <begin position="186"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="436"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="6">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="6">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="6">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN83965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="734" mass="83556" checksum="629BE2E03AEA2DBF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ACU3</accession>
    <name>A0A174ACU3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribbon-helix-helix protein, copG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199985.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86462">
        <property type="protein sequence ID" value="CUN86462"/>
        <property type="gene ID" value="ERS852478_01246"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032G0D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN86462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="109" mass="13095" checksum="10CEFA689571549D" modified="2016-09-07" version="1">MRKRNVQILFRLTEEEAEHLNEIVRKSGRSKEAFLREMVRGYQLCEKPDPEFYKMMRELSAIGNRINQLAVKANALGFVDTPMLREEARKWHEFQVDIRKRYLLPRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AEJ4</accession>
    <name>A0A174AEJ4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199989.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86613">
        <property type="protein sequence ID" value="CUN86613"/>
        <property type="gene ID" value="ERS852478_01250"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN86613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="414" mass="48498" checksum="C4A9CEB25E3D63D9" modified="2016-09-07" version="1">MDIRFSTYNDFLTEYQTYKLDKCSNCEGVRELIDDDVTVVIENRTLHFPELLVLCCNKCGDKCLPEYSKQIIDGAYKSMIEQEQFVGEFVSKSYKKKFEYCKETDYKYDHKDYYNIPGLCYDEEHSTEGFLTPVYFDRKALIYFISVPDFEVDIFSETYGHIGKKDPQGVYIYDWDVPFGFNSNGKLVFWLGDLNYMDTQSQAILKGFNVDSDHLIVDSEFFQAQMNCTFSKPIIEKQILMNKDSFISNIKKKYNIDLAHLDEECSEHAKNIKRPLVFTEQSVSGVINAFDKVLVEGFNVGRLRELYEALYSENERDAQYGKWQSIRLIKEILLKFCNGIGNTIDVEKLISPLYILHDYRIYFDHLLSMDKQESTKAHIVETLGVQNFSEQEAIYLEEIDRLNKLFQYLVLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AG83</accession>
    <name>A0A174AG83_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86919">
        <property type="protein sequence ID" value="CUN86919"/>
        <property type="gene ID" value="ERS852478_01258"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50330B7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN86919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="56" mass="6853" checksum="8E0417E6E24948DB" modified="2016-09-07" version="1">MRKRSAEEKQKQLERFLMNVAEAADAALWEYWREKEAEHRRFATEYVTRRGLIPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AJ63</accession>
    <name>A0A174AJ63_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Periplasmic serine endoprotease DegP</fullName>
            <ecNumber evidence="6 7">3.4.21.107</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Serine protease Do-like HtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">degP</name>
        <name evidence="7" type="synonym">htrA_1</name>
        <name evidence="7" type="ORF">BWLFYP14_01617</name>
        <name evidence="6" type="ORF">ERS852478_01275</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.21.107" evidence="6 7"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87496">
        <property type="protein sequence ID" value="CUN87496"/>
        <property type="gene ID" value="ERS852478_01275"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="327"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN87496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX64763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="421" mass="46477" checksum="B5F5BC11E2285B57" modified="2016-09-07" version="1">MKKNKMDTQEYQFIKETVKKQPKENGSLLRRLLMIAGCGVLFGSCAAVTFASVFPVMADREENTQQKIELTGSDVAETISEEQATERESVASVSEQEEKSLLAMRQEMYREVLKVSQKSRKSLVNVRGISKDEDLLNNSYLQQEDTEGLVFLETETQFYILTYEEEMENLQELQVTFADGSTVQGEICRGDADSGFAVATVRKNLLNDSTREGIVVSDLTDTKKLGQSDIVIAIGSPAGDSDAVVYGMITSVSEKLSVADTEYNVLATDVQGNEDGSGVLLDSDGNVAGMILKKNENDGDNIHAVSISQILPLIEHLANKETIRYTGIYGTEITQAQCRKLGIDQGLYVERTQEESPAMKAGIQCGDIISKIDGTPTESMQSYYTYLQTKKQGENLTITVLRKNSDGEYAEKDYKVTVGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AJB0</accession>
    <name>A0A174AJB0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-acetylmuramoyl-L-alanine amidase CwlA</fullName>
            <ecNumber evidence="4">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cwlA</name>
        <name evidence="4" type="ORF">ERS852478_01306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.28" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88494">
        <property type="protein sequence ID" value="CUN88494"/>
        <property type="gene ID" value="ERS852478_01306"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06583">
        <property type="entry name" value="PGRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036505">
        <property type="entry name" value="Amidase/PGRP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002502">
        <property type="entry name" value="Amidase_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01510">
        <property type="entry name" value="Amidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00644">
        <property type="entry name" value="Ami_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55846">
        <property type="entry name" value="SSF55846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetylmuramoyl-L-alanine amidase" evidence="3">
        <location>
            <begin position="119"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN88494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="277" mass="31152" checksum="A8061CA93454C008" modified="2016-09-07" version="1">MQKHINKKKKTDTRTGKTAVKKKNSRSKRRKSSRVRQRNQRILMSLMLLVIIVLIGWIIINRASENGWSIGDFLHNSDTMISDAEQSGTDNADSSGGPEQWQKEGAPYIDVELLTPNEYSRPQIPIESVQYIAIHYTANPGATAIANRNYFENLATTHDTKVSSHFVVGLDGEVVQCIPTSEMSYATNSRNVDTLSIECCHPDETGKFNEATYDSAVKLSAWLCVRFGLTSENVIRHYDVTGKNCPKYYVENPDAWIQMKSDIAAQIDVDYGLQDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ANA9</accession>
    <name>A0A174ANA9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltose-binding periplasmic proteins/domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200020.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89693">
        <property type="protein sequence ID" value="CUN89693"/>
        <property type="gene ID" value="ERS852478_01336"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017799" evidence="1">
        <location>
            <begin position="28"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN89693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="411" mass="46051" checksum="1B375B39888204F1" modified="2016-09-07" version="1">MRKKVLSAVLAATMVAGMMGNVVSVSAEEKYDLTLYSVNTTDPDFDDWLANVEEATGLNINVIAAPTDTDTRQQKITTILSTGDSSVDIVEINDEMSAAFKNSGWLEGLNDTVMTDDIIDQFAQGYIQDMITDKDGNIVGVPGYTGYLAFWVNQEIMDEVGIESIDTKEDFMKYMEAVSKDGRFGYGGSWEKTYAFNEIAQFVNMFGGDYFDWTKEENKEAIQFLHDLVANKETPVDQIADKYDQMNPKINDGKYGCWFMWGLGTDYAKADMLGADKIHMAMVPDFSGNGERAIFTDSWSYVLNSASKNKDAAIKFLQYMADEGGMEASYKAFDRYPARKDVAEKVVPDTDPAKEIYSQYAEECNVQGRPLVAQTMEFISDMGTIFQSCMKDEITVDEFCKKAQEVVDTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ANQ2</accession>
    <name>A0A174ANQ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200024.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89853">
        <property type="protein sequence ID" value="CUN89853"/>
        <property type="gene ID" value="ERS852478_01341"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZUHG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN89853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="160" mass="17528" checksum="E0CDFAA9FF2EB42B" modified="2016-09-07" version="1">MEKNENEELLEQSPADIQQEETQEIAKSGEEEPDTEEQKVSNGRFILWSLAGVYLLYTSYSLCKGYVTGEEGTSMGFMLAGIAFAAIGAGLLFFGIKNMLSEEKIRKAKAAKNAAMEAAAGGELKKEDASGQNRSMSIAERANMVKNLEDEEEDGENEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AW63</accession>
    <name>A0A174AW63_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN92714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200053.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN92714">
        <property type="protein sequence ID" value="CUN92714"/>
        <property type="gene ID" value="ERS852478_01394"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN92714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="159" mass="18080" checksum="4B1DD24015A29BE3" modified="2016-09-07" version="1">MPKFATKAADNMFCQARYEAAKFNERLSSREGAAEELGVDRTRLARIELGSVTPYPEEVLLMADIYRAPELKGNYCREMCPLGKGMPKIESHQDIDRIALRALCSFRKINEAKELLLDITADGVITEDEKSDLEKIINTLDEVNEVTQNLKNWIEKTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B4X1</accession>
    <name>A0A174B4X1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95259">
        <property type="protein sequence ID" value="CUN95259"/>
        <property type="gene ID" value="ERS852478_01474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN95259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="57" mass="6861" checksum="DE59A0B593698CA7" modified="2016-09-07" version="1">MTISEMRERLKVSRAEFSRRYNIPIRTLENWESGKSKCPDYVRQLLERAVLEDCEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B5R5</accession>
    <name>A0A174B5R5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200111.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95090">
        <property type="protein sequence ID" value="CUN95090"/>
        <property type="gene ID" value="ERS852478_01469"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN95090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="154" mass="17692" checksum="C64275129BC99DEA" modified="2016-09-07" version="1">MEVKLCVAKEARRKSNIEVLEIKYGGIEMTLKEILEAGGGILFVVLTLVQVAPIKVNPWTVLGRSIGRVLNKEVMDKIEEGNAKNARYRIIRFNDEVKHDVKHTEEHFDQIIEDIDTYENYCSDHPHFPNGKAVHSISNIRKIYDKCSDEHSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BSM8</accession>
    <name>A0A174BSM8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200165.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03617">
        <property type="protein sequence ID" value="CUO03617"/>
        <property type="gene ID" value="ERS852478_01686"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="53"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO03617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="295" mass="34258" checksum="265AA9CBAE53E274" modified="2016-09-07" version="1">MRQNTKKKRSGFGYFIRMFLLLVELLAVTLFLWGNDAYSISATTPEFKWENYKTIAHALGGIGDKTYLNSKESFLAGYQMGCRLFEVDLVKTSDNVWVCRHSWYQPLGQWEGDEKKVLSSEEFLSRPIYGKYTPITFEDLLVLLSDYPDTFVMLDSKQYSVRNYQKTVEDYADYIELAEAAGVPDVMGQIIPEIYNQAMFAGTALLYDFPGYIYSLWQEYSTEELTEIAAFCKEKNIQAATVYYKYWSEDVQEIFDKKGIRLYIYTVNDLKEAQYYMQEGAAGVCSDYLQDTMFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BTZ8</accession>
    <name>A0A174BTZ8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">rpsE</name>
        <name evidence="15" type="ORF">BWLFYP14_00272</name>
        <name evidence="11" type="ORF">ERS852478_01674</name>
        <name evidence="12" type="ORF">ERS852523_01278</name>
        <name evidence="14" type="ORF">GT712_08905</name>
        <name evidence="13" type="ORF">GT728_04775</name>
    </gene>
    <organism evidence="11 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 16">2789STDY5834863</strain>
            <strain evidence="12 17">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="13 19 20" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 20">BIOML-A1</strain>
            <strain evidence="14 19">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="15 18" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707272.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2967"/>
    <dbReference type="EnsemblBacteria" id="CUO03160">
        <property type="protein sequence ID" value="CUO03160"/>
        <property type="gene ID" value="ERS852478_01674"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33140">
        <property type="protein sequence ID" value="CUP33140"/>
        <property type="gene ID" value="ERS852523_01278"/>
    </dbReference>
    <dbReference type="GeneID" id="66496137"/>
    <dbReference type="eggNOG" id="COG0098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO03160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP33140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL32533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS89186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VUX67431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="169" mass="18123" checksum="0469992B1E588B1B" modified="2016-09-07" version="1">MKRNLIDASQLELEDKVVSIKRVTKVVKGGRNFRFTALVVVGDGNGHVGAGLGKAAEIPEAIRKGKEDAIKKLVTVARDENNSITHDFVGKYGSAEMLLKRAPEGTGVIAGGPARAVIELAGIKNIRTKCMGSRNKQNVVLATIEGLRQLKTPEEVARLRGKSVDEILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C8D0</accession>
    <name>A0A174C8D0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Triosephosphate isomerase</fullName>
            <ecNumber evidence="2">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pgk</name>
        <name evidence="3" type="synonym">tpi</name>
        <name evidence="3" type="ORF">ERS852478_01805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08140">
        <property type="protein sequence ID" value="CUO08140"/>
        <property type="gene ID" value="ERS852478_01805"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO08140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="312" mass="34533" checksum="EC0DFED7B6D3E8B0" modified="2016-09-07" version="1">MSFYGEYEQTAKADGRYLLVNIVKEKGKNLMKHIYLNLKRFDVPVEFGGVNRLAPVADWASCIVKNTQEELKTYDPTEVEFGMYFPEVHLLNAVAAKTEGSPVQIGCQSVFRADTAVGGNFGAFTTNRPASAMVAAGCETTIIGHCEERNDKAGILAEAGVTDTDAVNRLLNQEIKCAIERGMKVLYCIGEKSEEQEQWQEVLGKQLEIGLKDVDTSKVVIAYEPIWSIGPGKTPAGKEYITKIAKFVKEKTNGMDIVYGGGLKQDNAEMLASIDEIDGGLIALTRFQGEIGYYPEEYLEIIRLYMGRENNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CKT2</accession>
    <name>A0A174CKT2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative virion core protein (Lumpy skin disease virus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200438.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12550">
        <property type="protein sequence ID" value="CUO12550"/>
        <property type="gene ID" value="ERS852478_01920"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03408">
        <property type="entry name" value="SPFH_like_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033880">
        <property type="entry name" value="SPFH_YdjI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13421">
        <property type="entry name" value="Band_7_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band_7_1" evidence="1">
        <location>
            <begin position="52"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO12550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="424" mass="45399" checksum="0899007BAA75DA13" modified="2016-09-07" version="1">MGLIKAAAGAFGGTMADQWKEFFYCDAIDKDVLVVKGEKRVGGRSSNKKGSDNIISSGSGIAVADGQCMIIVEQGKVVEVCAEPGQFTYDASTEPSIFAGSLGEGIHRTFDTVKKRFTFGGDTGKDQRVYYFNIKELVDNKFGTANPIPFRVVDRNIGLDIDVSVRCNGVYSYKIVDPLLFYTNVCGNVEQQYDREEIEVQLKTEFVSALQPAFAKISELQIRPSAIPGHVLELCDAMNEALTKKWQQTRGLAVVSIAMNPVTLPEEDAQLIKDAQKNAILRDPTMAAATLAGAQADAMKSAASNTAGAMTGFMGMGMAGQAGGANMQNLYQMGAQQQAAQNMQPASGAGTWKCECGAENTGKFCSECGKPKPQREEWICSCGAVNTGKFCSECGSPRPTGKWTCSCGAVNTGKFCAECGKPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CNU7</accession>
    <name>A0A174CNU7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13839">
        <property type="protein sequence ID" value="CUO13839"/>
        <property type="gene ID" value="ERS852478_01963"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO13839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="410" mass="47300" checksum="AA0A5EA4AE27366C" modified="2016-09-07" version="1">MVLLKYLLSGRQIPSNFYYYINEASDTSTVKYRFELKIEEKCYLVEYEIGLLKNGKKSFCISKEKFSQREMSEGKRITPVFDYQKGKKELFRPLKLYERFSKDIQNVIALGVAEQATQNYNEEKGVPEVSSFLFSRKAQEVFEKAEGEAALLALLSQCFQKYGIYALAVVENAQYGYLSLNLESMPVNIDWSDTIPKKGEGIFLRFTDINVVPKEVFPYVANTIKQINIVMKSLIPEINIEIYNAFDKLLKDGKDGVQFEIIAMRGENRIPLLYESAGIKKLISICSNLVDCYNRESYCLVVDELDSGIYEYLLGECLEVMQDKAKGQLIFTSHNLRPLEILENDSLLYTTVNPENCYIKSTYIKNTQNTRLSYLRTIKLGGQKEKLYNETNIYEMELAMRRAGRIRAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CNY3</accession>
    <name>A0A174CNY3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Selenide, water dikinase</fullName>
            <ecNumber evidence="5">2.7.9.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Selenium donor protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Selenophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">selD</name>
        <name evidence="8" type="ORF">ERS852478_01973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Synthesizes selenophosphate from selenide and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate</text>
            <dbReference type="Rhea" id="RHEA:18737"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:29317"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the selenophosphate synthase 1 family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.3" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO14854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707503.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO14854">
        <property type="protein sequence ID" value="CUO14854"/>
        <property type="gene ID" value="ERS852478_01973"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0709">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02195">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00625">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023061">
        <property type="entry name" value="SelD_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004536">
        <property type="entry name" value="SPS/SelD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256">
        <property type="entry name" value="PTHR10256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036407">
        <property type="entry name" value="Selenphspht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00476">
        <property type="entry name" value="selD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0711">Selenium</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="49"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="167"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="47"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO14854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="345" mass="37099" checksum="959FC3D0A3A5F237" modified="2016-09-07" version="1">MKKNEVRLTQLASAAGCGAKIGPKVLAQVVGKLPKFTDPMLLVGPETSDDAAVYKINDELAMIHTVDFFPPVVDDPYMYGQIAAANALSDVYAMGGVPKLALNVVAFPNCLGPEVLEQILRGGADKVMEAGAVLAGGHTINDKEPKYGLCVTGYVHPDKMWKNYGAEEGDILILTKPLGCGILNTAIKAEMASQEEIERVQKIMAKLNKYAAEIASKYTIHSCTDVTGFSLAGHSLEMAKGSRKTLVIQSEKLPIIEGVEEYAQMGLIPEGAYRNRDFAGDEVRSEIKELWMEDLVFDPQTSGGLLLAVPAEEADALAEELAGMDIFGGVIGYVTELQDKAVVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CV68</accession>
    <name>A0A174CV68_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor sigM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sigM_2</name>
        <name evidence="4" type="ORF">ERS852478_02037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200503.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16917">
        <property type="protein sequence ID" value="CUO16917"/>
        <property type="gene ID" value="ERS852478_02037"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="116"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO16917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="182" mass="21529" checksum="BF422B3A0C4E3397" modified="2016-09-07" version="1">MVTDEELYGQYLCGDETGLELLIKKYGDPLTLYIDGYLHDVHEAEDLMMETFSWLFMKKPRIRNGCFKAYLYKAARHMALRHKSRRRIIFSLDNLTREPEAQTLVEEVVRTKERNQILHLCMDELNPDYREALYLTYFEGMSYQQAAEVMGKSVKQITNMVYRGKERLRGLLQREGITDVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CXD5</accession>
    <name>A0A174CXD5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Recombinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Recombinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BWLFYP14_02369</name>
        <name evidence="4" type="ORF">ERS852478_02075</name>
        <name evidence="6" type="ORF">GT712_14180</name>
        <name evidence="5" type="ORF">GT728_13880</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">BIOML-A1</strain>
            <strain evidence="6 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO18161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000035">
        <property type="protein sequence ID" value="MZL34263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000030">
        <property type="protein sequence ID" value="MZS90186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053834.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18161">
        <property type="protein sequence ID" value="CUO18161"/>
        <property type="gene ID" value="ERS852478_02075"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="7"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="168"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="442"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO18161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL34263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS90186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX65999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="545" mass="62901" checksum="DEE6773422CD4F79" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D0T0</accession>
    <name>A0A174D0T0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">smpB</name>
        <name evidence="4" type="ORF">ERS852478_02069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580321.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17939">
        <property type="protein sequence ID" value="CUO17939"/>
        <property type="gene ID" value="ERS852478_02069"/>
    </dbReference>
    <dbReference type="GeneID" id="66493743"/>
    <dbReference type="eggNOG" id="COG0691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO17939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="156" mass="18249" checksum="00764C95998F1C5E" modified="2016-09-07" version="1">MAKKKGMKLIANNKKAFHDYFIEDTYEAGIALAGTEVKSLRMGKCSIKESFIRVENGEVYIYGMHISPYEKGNIFNKDPLRIRKLLLHRYEINKIEAKLKEKGLTLVPLKVYFKDSLVKVEIGMARGKKLYDKRQDIAKKDQRREAERDFKVKNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D3W2</accession>
    <name>A0A174D3W2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02120</name>
        <name evidence="2" type="ORF">GT712_11560</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006427156.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20143">
        <property type="protein sequence ID" value="CUO20143"/>
        <property type="gene ID" value="ERS852478_02120"/>
    </dbReference>
    <dbReference type="GeneID" id="64017283"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO20143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS89691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="332" mass="38864" checksum="56DD0137A44925A1" modified="2016-09-07" version="1">MESVNYEYFDSENDYSKNPNATKHRSFNVSRGDFSKYAILNGFYGKKLISRDARKFYSSMCRMAVKKEKGFYVISDEYEFAETSYKNVISFAMGMLATRIIANEIYNINKLYHFTDKSFKGTLVNGKMAPDWIGVDGQKKVFLFESKGTCNKNVRKKTIEHAKVQLNNVGSIKDTSTNQMYYPQKDSKHVICSCFDAYSGIDKVWNIHDVDPEGKGEVNLEINFDKECFMYYQAFVSYVDSLNQVYQCESVKNQKYYCWVYEDEKYCILEEIYNSMKSGQFNEQNRYRNFNNYVNEKLSDIEYPEQFSHDGISSYEDGIVVCSSVSWRDKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D4Q8</accession>
    <name>A0A174D4Q8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FUSC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02814</name>
        <name evidence="2" type="ORF">ERS852478_02123</name>
        <name evidence="3" type="ORF">GT712_11545</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060228.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20227">
        <property type="protein sequence ID" value="CUO20227"/>
        <property type="gene ID" value="ERS852478_02123"/>
    </dbReference>
    <dbReference type="GeneID" id="66495362"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO20227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS89689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="354" mass="39806" checksum="9D627B3F195FE878" modified="2016-09-07" version="1">MTFYQELQLNQTGSKNLLKKSETLKEKLYHMWVYLVKIAVTMAFCFFFVSIFSILFGNENSIVGVVVLLCLMVFRNADLGIHTGQSTMLLALFFVIMTVCPHLANQFSPVLGMLLNIAALAVLILFGCHNPFMFNQSTLVLGYLLLYGYDVTGKSYQMRLVGMALGAALTCFVFYRNHKNRTYKRNLKDLIQEFDITSSRTKWQICQILCVPIVLCIAELCNMPRAMWAGIAAMSTILPFMEDMHYRVRKRIVGNIAGVICFTVLYFLLPSSIYAYIGILGGIGVGFSAQYGWQAVFNTFGALAIAAETYGLQGAVSLRVIQNVFGVVFALAFCVIFYWFMSKKKESEVTVHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D791</accession>
    <name>A0A174D791_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Site-specific tyrosine recombinase XerC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_02166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200600.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21592">
        <property type="protein sequence ID" value="CUO21592"/>
        <property type="gene ID" value="ERS852478_02166"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="200"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO21592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="488" mass="56391" checksum="EC7E0B4DD5974512" modified="2016-09-07" version="1">MASIKKRKSTFSVIYWYLDNAGERKQKWDTLETKKEAKQRKAFVEYYQEKYGYVIVPLEEQFARQIDESKKELDSTDEDITLCDFLKIFVNLYGTSKWSPSTFSSKVGTIENYINPLIGDWKLNEITTKKLSAYYNDLLSVPEVPRANRKATGRCVQPANIKKIHDIIRCALNQAIRWEYIDTNKRNPASLATLPKVPKVKRKVWSVDTFREAIQQSDDDLLTICMHLAFSCSMRIGEITGLTWEDVVIDEQSIATNNARVIINKELSRVNAQAMQKLKEKDIIKIFPTQKPHCTTRLVLKTPKTETSNRTVWLPKTVAELLVQYQKDQKELQEFLGDAYNNYNLVIALENGNPVESRIVRDRFQKLCEQNGYEQVVFHSLRHLSTGYKLKMTNGDVKSVQGDTGHAEAEMVTDVYSEIIDEDRRYNAQKMDEQFYSTLNHDSEMQPQNEEVQPENNGLSDSDMELLQFLKSLTPEMKAMLLKQSASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DCJ7</accession>
    <name>A0A174DCJ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379907.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21750">
        <property type="protein sequence ID" value="CUO21750"/>
        <property type="gene ID" value="ERS852478_02172"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027981">
        <property type="entry name" value="DUF4446"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14584">
        <property type="entry name" value="DUF4446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO21750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="172" mass="19772" checksum="BF83545C33F411C6" modified="2016-09-07" version="1">MSGIFESLGIDSGIIIIILLILTIFLLVRNISMNMRLSRLERKYKTFMKGSDAQSLEKVFVRKFAQIDKLYDAKEEHDHDLLFIKKNLDKMFSKYGVEKYDAFDDVGGKLSFALALLDKENTGLILNAVHSRDNCFLYMKEIVKGESYVMLSQEEVEALRKAVNFGLDNIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DE44</accession>
    <name>A0A174DE44_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphorylated carbohydrates phosphatase</fullName>
            <ecNumber evidence="1 2">3.1.3.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Phosphorylated carbohydrates phosphatase TM_1254</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_01470</name>
        <name evidence="1" type="ORF">ERS852478_02218</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="1 2"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO23764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705471.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23764">
        <property type="protein sequence ID" value="CUO23764"/>
        <property type="gene ID" value="ERS852478_02218"/>
    </dbReference>
    <dbReference type="GeneID" id="66495137"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO23764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX64617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="221" mass="24232" checksum="5C2F47C13F9ED1BC" modified="2016-09-07" version="1">MASGIDTVIFDMDGVIFDSEILVLQAWKEVAERHGIAGVEAACHECLGTNSVVSKGVFLKHYGEDFPYEEYKAEMAEVFFSHASGGKLAKKPGVEELLKYLKMRGFKIGLASSTREVLVRSEISDGGLLGYFDQIVGGDMVERSKPEPDIFLEACRRLGTRPENCYVIEDSHNGIRAAYAAGMHPIMVPDLMEVTEEMKSLAEEILGSLCAVQEFLQGSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DS88</accession>
    <name>A0A174DS88_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 15" type="primary">leuS</name>
        <name evidence="16" type="ORF">BWLFYP14_02926</name>
        <name evidence="15" type="ORF">ERS852478_02349</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000072">
        <property type="protein sequence ID" value="VUX66650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059424.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28343">
        <property type="protein sequence ID" value="CUO28343"/>
        <property type="gene ID" value="ERS852478_02349"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="13">
        <location>
            <begin position="39"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="14">
        <location>
            <begin position="220"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="415"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="651"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="579"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO28343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VUX66650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="800" mass="91014" checksum="05109724FEE29FF1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DWS8</accession>
    <name>A0A174DWS8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cobD_1</name>
        <name evidence="4" type="ORF">ERS852478_02389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060040.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29667">
        <property type="protein sequence ID" value="CUO29667"/>
        <property type="gene ID" value="ERS852478_02389"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="26"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO29667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="363" mass="41464" checksum="BD7ECBB3DD3DE40B" modified="2016-09-07" version="1">MSTAKMVFHGSDIEKICEVYQLKPEEIVKFGANVNPLGLSEHVKEQLAGRLDILSSYPDRDYTSLRSTISEYCNIPAEFILPGNGSSELIALLIQERNPKHTLILGPTYSEYSRELSFSGSTQEYYHLREEDNFVLNVDDLCHTLDGKYDFLILCNPNNPTSSAISINDLRRIVSFCNERNIFVMIDETYVEFAPDINEITAVSLTREFTNLMILRGVSKFYAAPGMRLGYGITGNLEFLKKMKEKQVPWSLNSLGALAGELMLKDKNYIRQTRDLILSERTRLLKALENIPTYKTYPAYANFLLLKIQKPGLTSRDVFDACIRQGLMIRDCSSFECLDGEYIRFCIMHPEDNTRLLHILESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E9H6</accession>
    <name>A0A174E9H6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380888.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000108.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33119">
        <property type="protein sequence ID" value="CUO33119"/>
        <property type="gene ID" value="ERS852478_02492"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO33119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="184" mass="20871" checksum="4E953192E8CD1B7F" modified="2016-09-07" version="1">MRILMLGNSFTTANHMPDMLDELTGAEIVQHTRGGARLAEQLNPKTKMGKRTQEALQNEKWDFVILQEMSNGPITSKASFLENAEKLCEKIRENGAKPVFYATWAYQRGGKKLETFGMDYDEMYQKLYEAYHLAADRNHTLIADVGKKFYELSDKVNLYADDGCHPNEKGSQIAAEIIAEVLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E9T0</accession>
    <name>A0A174E9T0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO34147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380368.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34147">
        <property type="protein sequence ID" value="CUO34147"/>
        <property type="gene ID" value="ERS852478_02533"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033TE1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043743">
        <property type="entry name" value="DUF5688"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18941">
        <property type="entry name" value="DUF5688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO34147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="316" mass="36916" checksum="09E3A050721EDAAC" modified="2016-09-07" version="1">MQKDYETFVEKLEIGIYEATGIPRENISFEKEGGRFAPVGDRLLVKFAEHDDAWEVCGLYTQELFKSYQNGSPFEEIIKEITDDLNRIKKADIYEKTRVIRDYEKTKPRLFIRLLNADKYSADLQDAVYKTLGDIALVLYMKVTEYEGCVTSTKIRQGMLEQWGKECDEVFKEAILNTYFMSPPRIYRWEQMIFNPEYEGESFMNLGDKCELKKDAMGNCLSTTKKTNGAVAVFLPGVAEQLAYMLDSDFYMVFTSVHEVMIHNDKFVEPEDLQCVLRDTIREATPKEDYLTSRIYQYNRETHKFICVTPLEKDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EB99</accession>
    <name>A0A174EB99_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35064">
        <property type="protein sequence ID" value="CUO35064"/>
        <property type="gene ID" value="ERS852478_02547"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO35064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="38" mass="4520" checksum="9C6EC6623B5396C4" modified="2016-09-07" version="1">MEFWLIMIGFIVMGGSCSLAGTWWDRKNKKDKKEEKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EH84</accession>
    <name>A0A174EH84_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-type taurine transport system, periplasmic component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380773.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35886">
        <property type="protein sequence ID" value="CUO35886"/>
        <property type="gene ID" value="ERS852478_02573"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027024">
        <property type="entry name" value="UCP027386_ABC_sbc_TM0202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027386">
        <property type="entry name" value="UCP027386_ABC_sbc_TM0202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020759" evidence="1">
        <location>
            <begin position="30"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="NMT1" evidence="2">
        <location>
            <begin position="101"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO35886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="324" mass="34796" checksum="FF2F677BD8ED0E4B" modified="2016-09-07" version="1">MKRKLMICAMALCICAGLTGNTGEVSVWASEGSSSDAVRIGALKGPTAMGMAQLLDEDGYDFTIAASPDEIVPMVVQDKLDIAAVPANLAATLYQKTDKDVSVLEVNTLGVLYLVENGDSVKSVEDLKGKTIYASGKGATPEYALNSVLKANGIDPEKDVTVEFKSEHAEVVSALVQDQTAVGLLPQPFVTTALMKNDKLKVALDLNKLWEDSMDDGSKLVTGVVIANNEFVQDHADKVNDFMDAYKESVDFVNSDTEAAAQIIGDHDIIAKEVAQKAIPDCSIVFIEGDEMKTMLSGYLATLDDQNPEIIGGQLPDDAFYYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EJR4</accession>
    <name>A0A174EJR4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">alr</name>
        <name evidence="7" type="ORF">ERS852478_02614</name>
        <name evidence="8" type="ORF">ERS852523_00211</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
            <strain evidence="8 10">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000002">
        <property type="protein sequence ID" value="CUP00342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059578.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000003_gene1628"/>
    <dbReference type="EnsemblBacteria" id="CUO36988">
        <property type="protein sequence ID" value="CUO36988"/>
        <property type="gene ID" value="ERS852478_02614"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP00342">
        <property type="protein sequence ID" value="CUP00342"/>
        <property type="gene ID" value="ERS852523_00211"/>
    </dbReference>
    <dbReference type="GeneID" id="66494100"/>
    <dbReference type="eggNOG" id="COG0787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="247"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO36988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP00342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="381" mass="42708" checksum="56894A55BA4E5CD2" modified="2016-09-07" version="1">MKKDSRVKAVISLDAVEHNFREMRKNIAEETKMIAVIKADAYGHGAVPVAHLIEDYDYIWGFAAATAEEAIHLREAGITKPILILGIVFDEYFPELVRYEIRPAVCEYEEARKLSDEAVLQKKTVHIHIALDTGMTRIGFADAQENVEEIKKISELPNLKIEGMFTHFARADEYDRSPAMVQLERYLDFSRRVEEAGVEIPLHHCSNSAGIIRMPEANLNIVRAGITIYGIYPSSEVERDIVKLEPVMELKSHVTYVKDVPAGAAISYGGTYVADRKLRVATVPVGYADGYSRQLSNKGWVLIHGQKAPILGRVCMDQFMVDVTEIGDVKKGDEVTLIGRDGDEFIGIEEIGDLCGRFSYEFACDISPRVPRVYIKNGKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EK36</accession>
    <name>A0A174EK36_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="8">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">leuB_1</name>
        <name evidence="17" type="synonym">icd</name>
        <name evidence="17" type="ORF">BWLFYP14_01459</name>
        <name evidence="14" type="ORF">ERS852478_02618</name>
        <name evidence="16" type="ORF">GT712_07460</name>
        <name evidence="15" type="ORF">GT728_02860</name>
    </gene>
    <organism evidence="14 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 18">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="15 20 21" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 21">BIOML-A1</strain>
            <strain evidence="16 20">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8 11">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO37108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000011">
        <property type="protein sequence ID" value="MZS88908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000033">
        <property type="protein sequence ID" value="VUX64605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703938.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37108">
        <property type="protein sequence ID" value="CUO37108"/>
        <property type="gene ID" value="ERS852478_02618"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="PTHR11822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 12" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Iso_dh" evidence="13">
        <location>
            <begin position="9"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="94"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="307"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="9">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="9">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO37108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL32160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZS88908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VUX64605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="402" mass="45690" checksum="4CE9B0B6A174B793" modified="2016-09-07" version="1">MKKIQMQTPLVEMDGDEMTRILWKIIKDELLLPYIDLNTEYYDLGLEYRNETDDQVTVDAAEATKKYGVAVKCATITPNKARMEEYTLKKMYKSPNGTIRAILDGTVFRAPIVVKGIEPCVKNWKKPITIARHAYGDVYKNTEMYIDGPGDAYLVFEGADGQQRKELIHHYEGPGVLQGMHNLDDSITSFARCCFNYALDTKQNLWLGGKDTISKIYDGRFKEIFATIYEDEFKEKFEAAGIEYFYSLIDDIVARVMKAEGGFIWACKNYDGDVMSDMVSSAFGSLAMMTSVLVSPQGYYEYEAAHGTVQRHYYRYLKGEETSTNSVATIFAWTGALRKRGELDGNKELMEFADKLEKATLETIESGKMTKDLALITSLEDVTVLNSKDFILAIRERLDEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EME6</accession>
    <name>A0A174EME6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="15">ATP-PFK</shortName>
            <shortName evidence="15">Phosphofructokinase</shortName>
            <ecNumber evidence="15">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">pfkA_2</name>
        <name evidence="15 18" type="synonym">pfkA</name>
        <name evidence="20" type="synonym">pfkA_1</name>
        <name evidence="20" type="ORF">BWLFYP14_00912</name>
        <name evidence="17" type="ORF">ERS852478_02649</name>
        <name evidence="19" type="ORF">GT712_04935</name>
        <name evidence="18" type="ORF">GT728_07015</name>
    </gene>
    <organism evidence="17 21">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 21" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 21">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="18 23 24" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 24">BIOML-A1</strain>
            <strain evidence="19 23">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="20 22" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 15">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="15"/>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000012">
        <property type="protein sequence ID" value="MZL32956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000007">
        <property type="protein sequence ID" value="MZS88449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993323.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38417">
        <property type="protein sequence ID" value="CUO38417"/>
        <property type="gene ID" value="ERS852478_02649"/>
    </dbReference>
    <dbReference type="GeneID" id="66492688"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00339">
        <property type="entry name" value="Phosphofructokinase_I_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012828">
        <property type="entry name" value="PFKA_ATP_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02482">
        <property type="entry name" value="PFKA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="16">
        <location>
            <begin position="9"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator; shared with dimeric partner" evidence="15">
        <location>
            <begin position="26"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="15">
        <location>
            <begin position="190"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="15">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="255"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUO38417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MZL32956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MZS88449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VUX63434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="332" mass="35784" checksum="1624F4B1419CE0CA" modified="2016-09-07" version="1">MAENKIKTIGVLTSGGDAPGMNAAIRAVVRRGLSNGLNVKGILKGYNGLLNEEIIDMSAKDVSDTIERGGTILYTARCAEFRTEEGQKRGAEICRKHGIDGLVVIGGDGSFAGAQKLANLGINTIGLPGTIDLDIACTEYTIGFDTAVNTAMEAIDKVRDTSTSHERCSIIEVMGRGAGYIALWCGIANGAEDVLVPEKYDYDEQKLINNIIESRKKGKKHHIIINAEGIGHSEAMAKRIEAATGIETRATILGHMQRGGSPTCKDRVYASMMGALAVDLLIAGKTCRVVGYRHGEFVDFDINEALAMQKGISDYQWEVCQSLSHNYDKNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EQK1</accession>
    <name>A0A174EQK1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="4">4.1.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fba</name>
        <name evidence="4" type="ORF">ERS852478_02698</name>
        <name evidence="5" type="ORF">ERS852523_02560</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
            <strain evidence="5 7">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000027">
        <property type="protein sequence ID" value="CUP71387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707962.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000070.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000099_gene787"/>
    <dbReference type="EnsemblBacteria" id="CUO40203">
        <property type="protein sequence ID" value="CUO40203"/>
        <property type="gene ID" value="ERS852478_02698"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP71387">
        <property type="protein sequence ID" value="CUP71387"/>
        <property type="gene ID" value="ERS852523_02560"/>
    </dbReference>
    <dbReference type="GeneID" id="66495162"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011289">
        <property type="entry name" value="Fruc_bis_ald_class-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01859">
        <property type="entry name" value="fruc_bis_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="208"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO40203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP71387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="287" mass="30727" checksum="38AD5793F008DCD6" modified="2016-09-07" version="1">MLVNATEMLKKAKAGHYAVGQFNINNLEWTKAILLTAQELNSPVILGVSEGAGKYMTGYKTVVGMVNGMMEELNITVPVALHLDHGSYEGCLKCVEAGFSSIMFDGSHYPIEENVAKTKELVKIVAEHGMSLEAEVGSIGGEEDGVVGMGECADPQECKMIADLGIDFLAAGIGNIHGKYPANWKGLSFETLDAIQKLTGEMPLVLHGGTGIPADMIKKAIDLGVSKINVNTECQLSFAAATRKYIEEGKDQQGKGYDPRKLLAPGFEAIKATVKEKMELFGSVNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F371</accession>
    <name>A0A174F371_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Iron hydrogenase 1</fullName>
            <ecNumber evidence="6">1.12.7.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_02825</name>
        <name evidence="7" type="ORF">ERS852523_03651</name>
        <name evidence="8" type="ORF">GT712_17430</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">2789STDY5834863</strain>
            <strain evidence="7 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.12.7.2" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO44017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000058">
        <property type="protein sequence ID" value="CUQ02226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000050">
        <property type="protein sequence ID" value="MZS90789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380573.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000118.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000104_gene843"/>
    <dbReference type="EnsemblBacteria" id="CUO44017">
        <property type="protein sequence ID" value="CUO44017"/>
        <property type="gene ID" value="ERS852478_02825"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ02226">
        <property type="protein sequence ID" value="CUQ02226"/>
        <property type="gene ID" value="ERS852523_03651"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027631">
        <property type="entry name" value="FeFe_hydrog_B1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04105">
        <property type="entry name" value="FeFe_hydrog_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO44017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUQ02226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS90789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="505" mass="55374" checksum="F4FB0CB33956E4F7" modified="2016-09-07" version="1">MRGLYSSKTEIRHKIFTEIARMAYEGQSPEMLEELPYKIVPGEIATYRDSIFLERAVVGERLRVAMGMSLRKVTEHAPISKGVEASVIEEKYYEPPLINVIKFACNSCPEKRVMITEGCQGCLEHPCVEVCPKKAVHMEGGRSHIDEDACIKCGKCLEACPYNAIIKQERPCSKACGMNAIGSDEYGRAEIDQDKCVSCGQCLVSCPFSAIVDKGQIFQTIMALKSETPVYAIVAPAIAGQFPGMENNKIRGAFQALGFTDVREVAVGADLCTVEEAKDFLEEVPEKLPFMATSCCPSWSMMAKKLFPEQAKCISMALTPMVLTARLIKQKEPDCKIVFVGPCAAKKLEASRKSIRSYVDFVLTFEEVAGMFDAKGVDWKDIPEGEPLFHASADGRGFAVSGGVAEAVVHAVKRIDPDREVKVMNAEGLQNCKKMLQMAKIGKYNGYLLEGMACPGGCVAGAGTIQTVKKAAAALEKMKKEASFTDAYDSKYRARLESLEKFDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FE06</accession>
    <name>A0A174FE06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_03394</name>
        <name evidence="1" type="ORF">ERS852478_02921</name>
        <name evidence="2" type="ORF">GT712_01165</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053915.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47056">
        <property type="protein sequence ID" value="CUO47056"/>
        <property type="gene ID" value="ERS852478_02921"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO47056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS87734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX67117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="64" mass="7401" checksum="ED54088B55A19594" modified="2016-09-07" version="1">MQRQNYMITAEEVAESMGISLGYAYKLLRKLNKELADQGYVTVAGKIPRAFWEKKFYGYSQIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FPH9</accession>
    <name>A0A174FPH9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03071</name>
        <name evidence="3" type="ORF">GT712_15175</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO52172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000035">
        <property type="protein sequence ID" value="MZS90374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060435.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52172">
        <property type="protein sequence ID" value="CUO52172"/>
        <property type="gene ID" value="ERS852478_03071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033253031" evidence="1">
        <location>
            <begin position="35"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO52172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="214" mass="22433" checksum="B73E078552F8B5C4" modified="2016-09-07" version="1">MTKIKNTKKGVAKKTLSMSLVVAMLATSNVPVWAAEFSDDFDAAVATEAPVTEFSDNTIETPAIEEETTEAPMAQAVVESDDLSVDVSVSESAEFTGIVSVSGTINASDLDKWGIDKQTIANYDVTIKDGVATVINDTIKVPVSEYTVTKNSDDTYTVAAKSTSKNYTGSKTVQAEGKAENKKPDALMISSVKVVGNKATVILSGASEGAAGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FRT5</accession>
    <name>A0A174FRT5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_03047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51546">
        <property type="protein sequence ID" value="CUO51546"/>
        <property type="gene ID" value="ERS852478_03047"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13145">
        <property type="entry name" value="Rotamase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021925" description="Peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="180"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="347"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO51546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="413" mass="45030" checksum="8E5418BF03A56365" modified="2016-09-07" version="1">MKKMVKRTAVVTLAGVMSVGMLSGCGSKTLDGTKTVATVDGTDIPLGVVSLYAREQQQQTTTMYLNYMGSADNIWDQTAGDDSDETYGDQAVTSSLESVEKMYILKEKAADYNVELTDDDEAAIADAASQFMAANSEETIKELAVTEDQVKTLLELQTIQKKMYDPVVAEGKITVSDDEANQTTFTYVSISTSGDDITDEEKKTKKEQAQEILDKMKEDPTADMSEIAKGVDDSYSAVQGNFTTKESEDEDEDSGSEAYPDEVLKVLRGLKDGEVADNIIETDTGYYVVRLDKINDEDATASKRESLQNSKENTYFTDTTAKWLDEADVKAVKKVLKTLKITDKHTFMAPTPTPVPETPTPEVTEEATPTPETEEVTETPAAEDTDVTETPAAEEEAAETTETPEATPTEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FTC5</accession>
    <name>A0A174FTC5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted P-loop ATPase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53453">
        <property type="protein sequence ID" value="CUO53453"/>
        <property type="gene ID" value="ERS852478_03107"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007936">
        <property type="entry name" value="VirE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05272">
        <property type="entry name" value="VirE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO53453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="442" mass="51190" checksum="9DC38EDF776BB5CC" modified="2016-09-07" version="1">MQPPQSVEEVKATLETTEKGGVRQSIRNCLTVFQRDPVLAGAIAYNILTDRKDIIKPIGFHRESTALTDTDMKYLLLYLEETYGLTSEKKIETAIGIVANENKYHPIRDFLNSLAWDGTERIRFCLRHFLGADVDDYTYEALKLFLLGAITRAFKPGSKFEIMLCLVGGQGAGKSTFFRLLAVRDEWFSDDLRKLDDDNVYRKLQGHWIIEMSEMMATANAKSIEEIKSFLSRQKEVYKIPYETHPADRPRQCVFGGTSNALDFLPLDRSGNRRFIPVMVYPEQAEVHILEDEAASRAYISQMWAEAMEIYRSGRYKLSFSPAMQRYLKEHQRDFMPEDTKAGMIQAYLDKYTGETVCSKQLYKEALNHTFDEPKQWEIREINEIMNQCITGWNYFSNPRMFAEYGRQKGWEREIPATDTDNPPEKSMDGFVEVTEQMELPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G1P9</accession>
    <name>A0A174G1P9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spermidine/putrescine transport system permease protein PotB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">potB_2</name>
        <name evidence="7" type="ORF">ERS852478_03193</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201230.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56383">
        <property type="protein sequence ID" value="CUO56383"/>
        <property type="gene ID" value="ERS852478_03193"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="68"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO56383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="287" mass="32308" checksum="7BC08339C164FEC4" modified="2016-09-07" version="1">MKKRRNRSDSSAWMALPLYIFTIVFVVCPLVYMVALSFATPSRGFGVTWKFTLDNYRNILEPVYLNTFVESLKLAFTSTIVIALIGYPFGYFMARLPEHRKKKAQLLLSTPFWVNSLIRLYGWIIILQKKGLLNFVLIKLGIIEKPLSILYSYPAIVIGMIYVLLPFMIMSVYSSAEKLDWSYVEAARDLGASRLQAFFTITLKLTLPGLLSGVILTFVPSMGLFFIADILGGNKVVLVGSLIQDQMTRGSNWPFAAALAVVMMVLTTVLIMIYRKVTNARELEGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G430</accession>
    <name>A0A174G430_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DegV domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DegV domain-containing protein SAV1425</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_00323</name>
        <name evidence="2" type="ORF">ERS852478_03214</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707361.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57213">
        <property type="protein sequence ID" value="CUO57213"/>
        <property type="gene ID" value="ERS852478_03214"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO57213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX67478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="289" mass="32270" checksum="C70FEAB5BD99AAB1" modified="2016-09-07" version="1">MSEYVITTDNNSDLPEEYLKDHGVGCMYLSYSMDGKNYTHGNFLPEHEFYEAMRNGSMPTTAQVNPENAKALLEPYLKEGKDILHIAFSSALSGTYNSSRIAAEELMEDYPDRKIIVVDSLGASLGQGLLVYLAQEKKEQGEDMETVAKWAEENRLHMVHLFTVNDLNHLYRGGRISRTTAVVGSMLNIKPVLHVDNDGKLTAIGKVRGRKKSLQELVKLMDEKIGSYHDTCHTIFISHGDCEEDANYVAEKVKEKYQINTIIMNQVGATIGAHSGPGTMALFFVGDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G733</accession>
    <name>A0A174G733_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xanthine permease XanP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xanP</name>
        <name evidence="8" type="ORF">ERS852478_03235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381368.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIOY010000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57791">
        <property type="protein sequence ID" value="CUO57791"/>
        <property type="gene ID" value="ERS852478_03235"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO57791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="486" mass="50260" checksum="88817723D1999C1B" modified="2016-09-07" version="1">MEKQEKNTVTPYDLDGRPPLKLAIPLGLQHVLAMFVGNLTPLLIITAACGIEAGGELQVALLQNAMLIAGIVTLVQVFTVGPVGGKLPIVMGTSSGFIGVCQSVAGVMGNGVVAYGAIMAASFIGGLFETVLGSFLKPLRKFFPSVVTGTVVLSIGLSLIAVGISSFGGGSSAKDYGSLENLFVGFVVLVVIVVLKHGTKGFTSFASILIGIIVGYVLVSIMAAVLPTTFTYVDDAGATVEATKSWVLNWDKVASASWFAVPKIMPVKWVFDARAIVPICIMFIVTAVETVGDISGITEGGLGREATDKELSGGVMCDGLGSSLAAVFGVLPNTSFSQNVGLVAMNKVVNRFSIATGGIFLIACGLFPKLAALISIMPQSVLGGAAVMMFSSIVVSGIQLITKWPVTPRNVTIVSVALGLGYGLGANSAVLAHMPQAITLIFGGSGIVPAALFAIILNIVLPPDEKSEVEIAEEILDIKKKEAQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GAZ5</accession>
    <name>A0A174GAZ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug export protein mepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_16</name>
        <name evidence="2" type="ORF">ERS852478_03279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO59071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060020.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59071">
        <property type="protein sequence ID" value="CUO59071"/>
        <property type="gene ID" value="ERS852478_03279"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO59071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="455" mass="48744" checksum="50E8603D890A780E" modified="2016-09-07" version="1">MTTSMIKGNPLKLMLQFAFPLLLGNLLQQTYNIIDAAIVGQILGAKALASVGASSSIQFLVLGFCMGSCTGFGVPVAKYFGAEKIEKMRDYIFNGAVLCAGIAVILTALCSVLCPQILHILSVPEDIYDNAYSYLLIIFLGIPFTILYNYLSSILRSVGDSRTPFIFLALSAVLNIFLDLFCIVVLKLGCAGAAIATISAQAISGILCLIFIIRKMKLLWLKKENRTIKGDAVKELLAMGMPTGLQFSITAIGSMVMQSANNRLGSTYVSAFTTAMKIKQFTMCPFDAIATSASVFCSQNLGAGQSDRIKKGLRCGITVGVGYGIVAGILLIFAGHTLSMLFVGKSAVAVLDASAKYLRCMGFFYWSLGILNVARMVTQGLGYSGRAVFSGVTEMIARTVVCLGFVGTFGFTAICFADQTAWITATCYIFPTCLWCIRKSTKMLASIAARVNNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GFR6</accession>
    <name>A0A174GFR6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase/pyrazinamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201292.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61392">
        <property type="protein sequence ID" value="CUO61392"/>
        <property type="gene ID" value="ERS852478_03340"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO61392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="173" mass="19008" checksum="54DC86160097AD53" modified="2016-09-07" version="1">MQKVLVVVDMQNDFIDGALGTKEAVAIVPGVKEKIENFDGVVLFTRDTHETYYLDTQEGKKLPVPHCIRDTEGWQIRSELDALRKTEPIDKETFGSTDLAGELVAMNEDNEIESITFVGLCTDICVISNALLAKASLPEVPIIVDAKCCAGVTPESHENALKAMEACQIQIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GIQ7</accession>
    <name>A0A174GIQ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201348.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61861">
        <property type="protein sequence ID" value="CUO61861"/>
        <property type="gene ID" value="ERS852478_03359"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033Y8M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO61861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="90" mass="10543" checksum="1005424BB10FFE6E" modified="2016-09-07" version="1">MASERTKELYRVLLSKGYPKELCAEIAYKNMNTDYTATRMLGYLYRYTNPKIEDLVDEMLAILTERAQIIEKKESEHAQAVISEMYRKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GMX7</accession>
    <name>A0A174GMX7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">adh</name>
        <name evidence="3" type="ORF">ERS852478_03373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO62260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201333.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62260">
        <property type="protein sequence ID" value="CUO62260"/>
        <property type="gene ID" value="ERS852478_03373"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="27"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO62260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="344" mass="37670" checksum="A1A29FD4664BFA87" modified="2016-09-07" version="1">MQTYTYVSKGKFELMEKPKPVLMHERDAVVKVTLASICSSDLHIKHGSVPRAVPGITVGHEMVGIIESVGSAVTHVKPGDRVTVNVETFCGECFFCKKGYVNNCTDENGGWALGCRIDGGQAEYVRVPFADQGLNKIPEGVTDRQALLVGDVLATGYWAARISEITEEDTVLIIGAGPTGICTLLSVMLKNPKCIIMCEKDENRIHFINEHYPEVLTVSPEECFDFVQDHSDHGGADVVLEVAGAESTFRLAWECARPNATVTVVALYDKAQVLPLPDMYGKNLTFKTGGVDGCDCEETLKLIAEGKINIEPLITHTYPLSRIEEAYELFENKRDGVIKVAVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GNV4</accession>
    <name>A0A174GNV4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyrosine-protein phosphatase CpsB</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cpsB</name>
        <name evidence="7" type="ORF">ERS852478_03387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Dephosphorylates CpsD. Involved in the regulation of capsular polysaccharide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Capsule biogenesis; capsule polysaccharide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO62858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201394.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62858">
        <property type="protein sequence ID" value="CUO62858"/>
        <property type="gene ID" value="ERS852478_03387"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00934"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045227">
        <property type="term" value="P:capsule polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016667">
        <property type="entry name" value="Caps_polysacc_synth_CpsB/CapC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39181">
        <property type="entry name" value="PTHR39181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19567">
        <property type="entry name" value="CpsB_CapC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016557">
        <property type="entry name" value="Caps_synth_CpsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO62858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="248" mass="28414" checksum="A6B4D1581414FF58" modified="2016-09-07" version="1">MSIKGIYDIHCHIVPGVDDGATDIGETVKLLRMEYEQGVRTVIATPHFRFRMFETPAEKVREQFRLVEKAASEISPDLHVYLGCEFHANMEMLPMLREQKVMTMAGSRYVLIEFSHNSEESYIRERLGALLSGGYKPIMAHIERYEITRNSLDFVEELADMGVYMQINADSITGKDGFFTKRYCNKIMKDGLLHFVGSDCHNSAKRSSRIGEAYRMVSAKFGQDYADELFIHNPAEILKQKQKHESAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GP66</accession>
    <name>A0A174GP66_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02274</name>
        <name evidence="1" type="ORF">ERS852478_03440</name>
        <name evidence="2" type="ORF">GT712_16240</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000042">
        <property type="protein sequence ID" value="MZS90567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058991.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64374">
        <property type="protein sequence ID" value="CUO64374"/>
        <property type="gene ID" value="ERS852478_03440"/>
    </dbReference>
    <dbReference type="GeneID" id="66495117"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO64374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS90567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="180" mass="20830" checksum="781161E4879F27EA" modified="2016-09-07" version="1">MSAQLDKIGENGKGYGHLEKVYSIWICLDNIPRKLENTISYYKMQNYKNEGIKDKEFRIDSWESDLLEIIIVRLGGEGQEEKGLLDLLYGLFSGNQKKVLSYIPDSDNQVRQKEVSDMLSMISYAEENGIKKGEKKGEKKGENRLGALINILLKNKRYSDAEKASEDEVYREQLYKEYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GQR5</accession>
    <name>A0A174GQR5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcriptional regulator yvhJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yvhJ</name>
        <name evidence="4" type="ORF">ERS852478_03383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO62745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201354.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62745">
        <property type="protein sequence ID" value="CUO62745"/>
        <property type="gene ID" value="ERS852478_03383"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="105"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO62745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="343" mass="38025" checksum="1476FCD1F9ED9D16" modified="2016-09-07" version="1">MKKNTRKAIRQRKICMLLIIILIIVLSILGGGYYLLSQKNAALPKIGGQNSDSLNQTDLNQNSDTVEYKGETYKYNDHLSNYLFLGIDTREAVDTYQSQADAGQADAIFLVSMDRATEKIKVLFIPRDSMTRIEVFNPYGQSLGETTDHLNIQYAFGDGKEKSCELMKTAVSGMLDGLPIQGYCSMNMDGISVITDFVGGIQLTIPDDSLADVNPEYKKGAVVDITGETAEQFVRYRDIDKTQSALVRQERQKTFLQALVQKAQEKAGEDAGFVTGLYDSVKSYTVTNMGNDIFAKLLAASQNGITDTETVPGEGTHGENFDEYHIDEDALSDLIISMFYEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GVP3</accession>
    <name>A0A174GVP3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS66 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transposase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02283</name>
        <name evidence="2" type="ORF">ERS852478_03449</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64595">
        <property type="protein sequence ID" value="CUO64595"/>
        <property type="gene ID" value="ERS852478_03449"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004291">
        <property type="entry name" value="Transposase_IS66_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03050">
        <property type="entry name" value="DDE_Tnp_IS66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66" evidence="1">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO64595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="99" mass="11357" checksum="4A5BC046DC14D3EC" modified="2016-09-07" version="1">MIYEYQKDRDHQKPLEFYRDYKGILVTDGLQQYHLVDKKLPDVTNANCWAHARRDFADAVKAMDKKDPSAGHSSVAYTALQKIGGFYTADTELKKLSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GW18</accession>
    <name>A0A174GW18_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DDE_Tnp_IS66_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66733">
        <property type="protein sequence ID" value="CUO66733"/>
        <property type="gene ID" value="ERS852478_03513"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039552">
        <property type="entry name" value="IS66_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13817">
        <property type="entry name" value="DDE_Tnp_IS66_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS66_C" evidence="1">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO66733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="74" mass="8282" checksum="A0E1CE38661E91CC" modified="2016-09-07" version="1">MIDTVNGANSSAIIYGIAETAKANNLKPFNYFEYLLAEIPKHVDDKNTDFLAELLPWSDMLPENIRKPQKASGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H4J0</accession>
    <name>A0A174H4J0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antirestriction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201439.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68256">
        <property type="protein sequence ID" value="CUO68256"/>
        <property type="gene ID" value="ERS852478_03565"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013610">
        <property type="entry name" value="ArdC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08401">
        <property type="entry name" value="ArdcN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArdcN" evidence="1">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO68256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="321" mass="36165" checksum="5A1A8C95CCC27DC2" modified="2016-09-07" version="1">MTKKYSDSEKKDKKAALKEITEQLEKSIHEFMNGEKYKNFLNQMSKFHSYSLNNQILIAIQRPEATICASYSGWKSQGRQVKAGERGIKIICPAPYKKEKIKDVIDPKTGKPELLADGNVKREIVEVIIPHFKIGHTFDVSQTEGKPLVELSQQLTGELTDYQKELRDALLQISPVPVSFQPIEGSANGFYSLDKNAITVDSTLSEKQSVKTLIHEIAHATIHNTNIPDAPKDSPTREVQAESIAYVVCQYFGMDVSDYSFGYIAGWSTGKDTKELKESLEIIRDTSNDIISKTEQTLTQMQSIKQTVSETIQPKRRGRCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H4M2</accession>
    <name>A0A174H4M2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adaptive-response sensory-kinase sasA</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sasA</name>
        <name evidence="4" type="ORF">ERS852478_03594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69191">
        <property type="protein sequence ID" value="CUO69191"/>
        <property type="gene ID" value="ERS852478_03594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO69191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="122" mass="13573" checksum="7AEC965B3BA8A025" modified="2016-09-07" version="1">MSVDCPEDLTVFHDSKWTSEALFNLLDNAVKYTPAGGKIAVSVVLWEMYVEIKVADTGKGISESNQAAIFRRFYREEEVHEQQGVGIGLYLAREIVTRQGGYIKVVSEPGKGSEFSIMLPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H972</accession>
    <name>A0A174H972_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phoR_12</name>
        <name evidence="7" type="ORF">ERS852478_03671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201483.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPB010000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71492">
        <property type="protein sequence ID" value="CUO71492"/>
        <property type="gene ID" value="ERS852478_03671"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008358">
        <property type="entry name" value="Sig_transdc_His_kin/Pase_MprB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01780">
        <property type="entry name" value="LANTIREGPROT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="241"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO71492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="454" mass="51003" checksum="72545C1BD9C22BE5" modified="2016-09-07" version="1">MGVKKKPTLKILFRQFAISLIVMLVAAIIVPSGLEGLAVNAGLATRANLSELQVKEIIPTLTIAPDITKVVIPQGCGYLILDKNFNELYSNMDDDEKEIALLYAKGEYIEYATGRQFALVVRENEFCVLRYYIGSQFTVSWLPEYFPSPDTLVFILMAVNSLLVIIILTARFAKNLRTQLTPLFEATAEVSKQNLDFEVGHAKIKEFEDVLASFSDMKDNLKISLERQWKTEQTQKEQIAALAHDLKTPLTVIQGNADLLTETNLDDEQRLYAGYVVESSGQMQSYIQTLIDISRAAVGYQLHIESIDLPAFMQHLFGYMESLCRTKEIRLQMNTVSLPQMLKFDRVLIERAIMNVISNGLDYSPQGGTLYVDVQSNNGFVEILVTDEGTGFSKEALCHAQERFYMGDQSRNSKLHFGMGLYITNSIMEQHNGQLILENSKETGGAKVTMKLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HBI3</accession>
    <name>A0A174HBI3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_00087</name>
        <name evidence="1" type="ORF">ERS852478_03638</name>
        <name evidence="3" type="ORF">GT712_04110</name>
        <name evidence="2" type="ORF">GT728_01760</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">BIOML-A1</strain>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL31959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704840.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70588">
        <property type="protein sequence ID" value="CUO70588"/>
        <property type="gene ID" value="ERS852478_03638"/>
    </dbReference>
    <dbReference type="GeneID" id="66494335"/>
    <dbReference type="eggNOG" id="ENOG50349VV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO70588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL31959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS88295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="61" mass="7099" checksum="7F77A4E9D15679FE" modified="2016-09-07" version="1">MEIEEEFISGFCRTCNGGQTVCCEYTMEGDKRTLTFMDCAHDRCVNYAACEIYKQAHEMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HCU7</accession>
    <name>A0A174HCU7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71166">
        <property type="protein sequence ID" value="CUO71166"/>
        <property type="gene ID" value="ERS852478_03657"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046103">
        <property type="entry name" value="DUF6040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19506">
        <property type="entry name" value="DUF6040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="162" mass="17962" checksum="421DA44B887EC65D" modified="2016-09-07" version="1">MIVVLWWYVIVTTIFAAIRSETFLGDFTVFVDTVWNGICQSGKWIVDVGNALAQAGDRIPNETMAIVAHWLLFIIVIVGAAVAVGVLMVIGEKKVTKVYRENCWDVISVGEAVTSVALVVYFGDWIKAFVKLNLVVLLLLVQAVYVGIRAYVKGCKRARGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HD47</accession>
    <name>A0A174HD47_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rffG_2</name>
        <name evidence="7" type="ORF">ERS852478_03718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="CYZN01000044">
        <property type="protein sequence ID" value="CUO72754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201505.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72754">
        <property type="protein sequence ID" value="CUO72754"/>
        <property type="gene ID" value="ERS852478_03718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="4"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO72754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="339" mass="38775" checksum="D909B2D9D12E68BA" modified="2016-09-07" version="1">MNIIVTGGAGFIGSNFVFHMLKKYPDYRIICLDKLTYAGNLSTLAPVMDNPNFRFVKADICDREAVDKLFEEEHPDIVVNFAAESHVDCSIEDPGIFLQTNIIGTSVLMDACRKYGIQRYHQVSTDEVYGDLPLDRPDLFFTEETPIHTSSPYSSSKAAADLLVLAYHRTYGLPVTISRCSNNYGPYHFPEKLIPLMIANALADKPLPVYGEGLNVRDWLYVEDHCKAIDLIIHKGRVGEVYNVGGHNEKQNIEIVKIICKELGKPESLITHVGDRKGHDMRYAIDPTKIHNELGWLPETKFEDGIKKTIQWYLDNREWWETIISGEYQNYYEKMYSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HE11</accession>
    <name>A0A174HE11_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000045">
        <property type="protein sequence ID" value="CUO73133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73133">
        <property type="protein sequence ID" value="CUO73133"/>
        <property type="gene ID" value="ERS852478_03729"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008023359" evidence="1">
        <location>
            <begin position="25"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO73133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="284" mass="29716" checksum="56F5D0999FF0D52C" modified="2016-09-07" version="1">MKLLRKQMLLCSILFLVFTLSACSAIGQTDENNLTDSATSAEKTVSVVRGTITPTVSTQTTIVPAVPFIISSPENGIFNTAVELEEKITAGQIIGTVNGKELKSPVDGTITSIAPSNESVPSNYPVAIVHYTGFALNVEADNFLSTLPEYAELKAKFQVYDGVGPTDMIAVVSPAADENAFTGIVPQEGILQCLISQTVDVKSGQSATVVITATTRNDVLILPLSVIAGRQGTGLVTVITPNGERVETKVTLGVTDGANIEILSGLEEGDVVSATPPNLDPRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HQY3</accession>
    <name>A0A174HQY3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yycF_5</name>
        <name evidence="7" type="ORF">ERS852478_03820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000053">
        <property type="protein sequence ID" value="CUO75966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75966">
        <property type="protein sequence ID" value="CUO75966"/>
        <property type="gene ID" value="ERS852478_03820"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO75966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="142" mass="16113" checksum="17957B90667A2199" modified="2016-09-07" version="1">MNKIAIIEDDIDICNMIAKFLENNKYIVHYALNGAEGIELCKSLVPDLIILDIMLPKLNGNDVLQRLRKFTNAPVIVVSAKTMVQTKIDLLKLGADDYMTKPFDLHELLARIEANLKRTSNTSCQNDTLTYRDIEINNSLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K5B2</accession>
    <name>A0A174K5B2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">cobU_1</name>
        <name evidence="20" type="ORF">BWLFYP14_02698</name>
        <name evidence="16" type="ORF">ERS852478_00202</name>
        <name evidence="17" type="ORF">ERS852523_00359</name>
        <name evidence="19" type="ORF">GT712_00450</name>
        <name evidence="18" type="ORF">GT728_05985</name>
    </gene>
    <organism evidence="17 22">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 21 22" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 21">2789STDY5834863</strain>
            <strain evidence="17 22">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="18 24 25" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 25">BIOML-A1</strain>
            <strain evidence="19 24">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="20 23" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000003">
        <property type="protein sequence ID" value="CUP04480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381052.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000025_gene955"/>
    <dbReference type="EnsemblBacteria" id="CUN46419">
        <property type="protein sequence ID" value="CUN46419"/>
        <property type="gene ID" value="ERS852478_00202"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04480">
        <property type="protein sequence ID" value="CUP04480"/>
        <property type="gene ID" value="ERS852523_00359"/>
    </dbReference>
    <dbReference type="GeneID" id="66495822"/>
    <dbReference type="eggNOG" id="COG2087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043752">
        <property type="term" value="F:adenosylcobinamide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUN46419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUP04480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MZL32767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MZS87597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VUX66325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="126" mass="13995" checksum="B93CE3BAC329A133" modified="2016-09-07" version="1">MEMIIGGAYQGKTEYARKQYPQLRWSDGGSVTEEELMNAQGVTGFQQYIRSELENGKDVSDLAEKIICKNPDIVLVSQEVGYGVVPVDAFDRKYREAVGRVCTKLAAYSHKVTRVICGIGTVIKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M485</accession>
    <name>A0A174M485_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00948</name>
        <name evidence="3" type="ORF">ERS852523_01176</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000009">
        <property type="protein sequence ID" value="CUP29936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74050">
        <property type="protein sequence ID" value="CUN74050"/>
        <property type="gene ID" value="ERS852478_00948"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP29936">
        <property type="protein sequence ID" value="CUP29936"/>
        <property type="gene ID" value="ERS852523_01176"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030IA6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN74050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP29936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="403" mass="46914" checksum="069359F0B914E0C3" modified="2016-09-07" version="1">MKVRMYNVGFGDCFCLRDRKKSLLVDFGTNNSRIEGRPRREIFDVIISDLSTIKSKNLLLTHFHMDHLSGLLYMMKKKDISVDFGKIYLPDVFSKKEMSRTLVLLLLADLLKESGLPSRQVSLFALVDALLENKQNVELLSRGKLFENKYQALWPDTDVIRKETDEVYNRICEDGKFKEVMDVLLEFAEKLRLIVWSMTAEGNKPAETVEKETDLTASELTEQPEVRQKIIRAYVYEREFRRIKALPDFKKLLAWLNENQINLRQFKHKISIVFQNARDGELNLLFTGDAQPEHLKMIAENYDGKLPLYEHYWCIKVPHHGTQGHYFDFSQYEPENMLISNGIHFANSKKESKELRTSPLYGGLFYIPDTHMYCSNCDCCDSYENGCSCKEADVISPAYYKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M9B9</accession>
    <name>A0A174M9B9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">map_2</name>
        <name evidence="2 7" type="synonym">map</name>
        <name evidence="5" type="synonym">map_1</name>
        <name evidence="9" type="ORF">BWLFYP14_00277</name>
        <name evidence="5" type="ORF">ERS852478_01679</name>
        <name evidence="6" type="ORF">ERS852523_01273</name>
        <name evidence="8" type="ORF">GT712_08880</name>
        <name evidence="7" type="ORF">GT728_04800</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707279.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2962"/>
    <dbReference type="EnsemblBacteria" id="CUO03380">
        <property type="protein sequence ID" value="CUO03380"/>
        <property type="gene ID" value="ERS852478_01679"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33002">
        <property type="protein sequence ID" value="CUP33002"/>
        <property type="gene ID" value="ERS852523_01273"/>
    </dbReference>
    <dbReference type="GeneID" id="66496142"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO03380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP33002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL32538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS89181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX67436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="251" mass="27751" checksum="4E23C4AAB4DA2D1B" modified="2016-09-07" version="1">MSVSIKTEHEIELMREAGHLLEKVHDGLIPYIKPGVSTKEIDRIGEQMIRDLGCIPNFLNYGGFPASFCISLNDEVVHGIPSEEKIIQEGDLVKIDAGLIYKGYHSDAARTYAVGEVSPQARKLMDVTRECFFEGLKAARAGNHLNDISKAIGAHAAKYHYGIVRDLVGHGIGTHLHEDPQIPNFPQKRRGVRLMPGMTLAVEPMINLGRADVAWLDDEWTVVTMDGSLSAHYENTILITDGDPEILTLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174Q5T7</accession>
    <name>A0A174Q5T7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-type ATP synthase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">V-ATPase subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ntpD</name>
        <name evidence="4" type="synonym">atpD</name>
        <name evidence="9" type="ORF">BWLFYP14_01156</name>
        <name evidence="5" type="ORF">ERS852478_01720</name>
        <name evidence="6" type="ORF">ERS852523_02336</name>
        <name evidence="8" type="ORF">GT712_12250</name>
        <name evidence="7" type="ORF">GT728_09940</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000024">
        <property type="protein sequence ID" value="CUP65409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000020">
        <property type="protein sequence ID" value="MZL33509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705345.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000018_gene55"/>
    <dbReference type="EnsemblBacteria" id="CUO05473">
        <property type="protein sequence ID" value="CUO05473"/>
        <property type="gene ID" value="ERS852478_01720"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP65409">
        <property type="protein sequence ID" value="CUP65409"/>
        <property type="gene ID" value="ERS852523_02336"/>
    </dbReference>
    <dbReference type="GeneID" id="66492354"/>
    <dbReference type="eggNOG" id="COG1394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="PTHR11671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO05473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP65409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS89824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX63797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="205" mass="23541" checksum="40119D16683B61D4" modified="2016-09-07" version="1">MDPNTFPTKGNLILAKNSLKLSRQGYELMDKKRNILIREMMELIDQAKDIQTQIDVTFRTAYTALQKANMEIGIAFVQQIACTVPVENSIRIKTRSVMGTEIPLVEYDKTTNTPTYAYYSTKMSLDEAKAAFEKVKELSIRLSMVENAAIRLAANIKKTQKRANALKNITIPKYEALTKDIQNALEEKEREEFTRLKVIKRMKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174Q727</accession>
    <name>A0A174Q727_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_01259</name>
        <name evidence="1" type="ORF">ERS852478_00877</name>
        <name evidence="2" type="ORF">ERS852523_02468</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000026">
        <property type="protein sequence ID" value="CUP69073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379846.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000023_gene1789"/>
    <dbReference type="EnsemblBacteria" id="CUN71890">
        <property type="protein sequence ID" value="CUN71890"/>
        <property type="gene ID" value="ERS852478_00877"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP69073">
        <property type="protein sequence ID" value="CUP69073"/>
        <property type="gene ID" value="ERS852523_02468"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50330BS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN71890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP69073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX64151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="122" mass="15219" checksum="3AF1F774DFD94E9B" modified="2016-09-07" version="1">MYLKEYFPFYTTYANPLLYEGERMQDKEFNLMKSYYPGTVQHIQEKIEEECDLMDYEGSRLYDEYPDKYMIYHLSCKIRESMEPEISTQAIREDFLDELIQVMLCQEISRRRCRRYRCRRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QR83</accession>
    <name>A0A174QR83_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">regX3_3</name>
        <name evidence="9" type="synonym">regX3_7</name>
        <name evidence="9" type="ORF">ERS852478_03616</name>
        <name evidence="10" type="ORF">ERS852523_02708</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
            <strain evidence="10 12">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO69886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000030">
        <property type="protein sequence ID" value="CUP75732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009265522.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000122.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000056_gene2499"/>
    <dbReference type="EnsemblBacteria" id="CUO69886">
        <property type="protein sequence ID" value="CUO69886"/>
        <property type="gene ID" value="ERS852478_03616"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP75732">
        <property type="protein sequence ID" value="CUP75732"/>
        <property type="gene ID" value="ERS852523_02708"/>
    </dbReference>
    <dbReference type="GeneID" id="61434858"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="127"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO69886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP75732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="229" mass="26123" checksum="9151559665A02623" modified="2016-09-07" version="1">MKHILIVEDDNLLNKTLTYNLELDGYTITSVLNARTAAESLKTNIFDLVLLDINLPDGNGYDLCRLIKPEHPDTVVIFLTANDQESNQIRGYEAGAVDYITKPFSISALQRKIKAMFAMLEHHKPAKDIYEDGSLFLDFSEQFASLNGKPLALSAMEYKMLNLFLKNPKQVLTRQQFLEKLWDVDEKYVDEHTLTTSISRIRSKIEADGDTYIKTVYGMGYQWTGGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174TW85</accession>
    <name>A0A174TW85_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_01840</name>
        <name evidence="2" type="ORF">ERS852478_00657</name>
        <name evidence="3" type="ORF">ERS852523_04045</name>
        <name evidence="5" type="ORF">GT712_17780</name>
        <name evidence="4" type="ORF">GT728_10290</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN63618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000077">
        <property type="protein sequence ID" value="CUQ12237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000022">
        <property type="protein sequence ID" value="MZL33577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000054">
        <property type="protein sequence ID" value="MZS90851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706577.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000022.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000132_gene729"/>
    <dbReference type="EnsemblBacteria" id="CUN63618">
        <property type="protein sequence ID" value="CUN63618"/>
        <property type="gene ID" value="ERS852478_00657"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ12237">
        <property type="protein sequence ID" value="CUQ12237"/>
        <property type="gene ID" value="ERS852523_04045"/>
    </dbReference>
    <dbReference type="GeneID" id="66493260"/>
    <dbReference type="eggNOG" id="ENOG5032ZDT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN63618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ12237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="73" mass="8497" checksum="C4F35ED41332C30D" modified="2016-09-07" version="1">MNIKIEELLSALNRKEEEKEKNTVLWVLAIIGAVAAVAGIAFAVYHFFAPDYLEDFEEDFDDDFDDYFEDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WVG6</accession>
    <name>A0A173WVG6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mercuric reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052796.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43090">
        <property type="protein sequence ID" value="CUN43090"/>
        <property type="gene ID" value="ERS852478_00079"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN43090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="86" mass="9366" checksum="9D087079560E9F2F" modified="2016-09-07" version="1">MIKTTVKVDGMMCGMCESHVNDAVRKAFQVDKVTSSHSKGETVIISDGPVDEAKLKTAISATGYEVKGITSEPYEKKKGLFSFLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X4G2</accession>
    <name>A0A173X4G2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobT</name>
        <name evidence="10" type="ORF">ERS852478_00205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobT family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381054.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46504">
        <property type="protein sequence ID" value="CUN46504"/>
        <property type="gene ID" value="ERS852478_00205"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN46504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="350" mass="37275" checksum="DAB6070350916F4D" modified="2016-09-07" version="1">MTLEEAIAKIKPLDHNAMEIAQKRWDSIAKPLHSLGKLETLLIQIAGITGNAEVDLSRRGLIAMCADNGVVEEGVTQTGQEVTAIVAENFLKYDTSVGVMCKQNHAEIFPVDMGMVTDTKVRTDHKIAYGTQNMTKGPAMTREQAVKGLEAGIDMVRELNDKGYRILATGEMGIGNTTTSSAVASVLLKQPVEEMTGRGAGLTSEGLVRKINAIKKAIALNEPDPEDAIDVLAKVGGLDIAGMAGVFLGGAVYGIPVVMDGFISCVSALIAMRICPAARDYILASHVSNEPAAHLILENMGKEAIIHADMCLGEGTGAVALFPILDLAAAVYHSMSTFDDIHVEQYEELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X725</accession>
    <name>A0A173X725_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter ATP-binding protein YheS</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Uncharacterized ABC transporter ATP-binding protein YheS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yheS_1</name>
        <name evidence="7" type="synonym">yheS_2</name>
        <name evidence="10" type="ORF">BWLFYP14_02707</name>
        <name evidence="6" type="ORF">ERS852478_00211</name>
        <name evidence="7" type="ORF">ERS852523_00368</name>
        <name evidence="9" type="ORF">GT712_00405</name>
        <name evidence="8" type="ORF">GT728_05940</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000003">
        <property type="protein sequence ID" value="CUP04680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703297.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000025_gene946"/>
    <dbReference type="EnsemblBacteria" id="CUN46677">
        <property type="protein sequence ID" value="CUN46677"/>
        <property type="gene ID" value="ERS852478_00211"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04680">
        <property type="protein sequence ID" value="CUP04680"/>
        <property type="gene ID" value="ERS852523_00368"/>
    </dbReference>
    <dbReference type="GeneID" id="66495813"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="320"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN46677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP04680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL32758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS87588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX66334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="546" mass="61655" checksum="5EEFA887CBCC1436" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XHD4</accession>
    <name>A0A173XHD4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50045">
        <property type="protein sequence ID" value="CUN50045"/>
        <property type="gene ID" value="ERS852478_00291"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN50045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="38" mass="4527" checksum="B644F011DC02EDD1" modified="2016-09-07" version="1">MKITEELLKEMKVKDENFSDGDYIRITKEHLLSSRCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XZA6</accession>
    <name>A0A173XZA6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199659.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56693">
        <property type="protein sequence ID" value="CUN56693"/>
        <property type="gene ID" value="ERS852478_00477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN56693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="80" mass="9153" checksum="99DA012EC3D8A786" modified="2016-09-07" version="1">MQLLFKSIPEAQGIFHLNLTKDTWISSNRVSRNVENLKDAPDVDMLIAQISAFIPNERMKEKFLGKKISFPVLEAMNSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XZX6</accession>
    <name>A0A173XZX6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ferrichrome/ferrioxamine B periplasmic transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199665.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56850">
        <property type="protein sequence ID" value="CUN56850"/>
        <property type="gene ID" value="ERS852478_00482"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015835" evidence="2">
        <location>
            <begin position="30"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="59"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN56850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="374" mass="40921" checksum="D099A4B6A3799C94" modified="2016-09-07" version="1">MKKHRQLLALFICLVMSVSLLTGYSETKAATEEPTQSAEQDATQETAETREITDMAGRKVTVPTAENIESVFSAGPVAAIFLYMVAPDKLLGWNYELNDVEKSIILDKYQDLPNFGMGDAVNYEAVIAANPTIAINSGKINDAMVSDCDALSESLGIPVVAVDNELNNSAEAFRFMGELLGVEDHAEELAQYAEQVFTDINALSDIPEEKKVSVYFGNGEDSLETAPRGSQHAQILDAINAVNVADLELGDGSRVQISAEQLLAWDPDVIVVNGEPKADKSGSSAAEDILSNPDYASLKAVQDQKVYGTPNAPFSWVDRPAGPNRLIGMRWFSALIYPEYIKCDINEEIHKFFDLFYHVDLSDEQLENVLKGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y7A5</accession>
    <name>A0A173Y7A5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706177.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000058.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60002">
        <property type="protein sequence ID" value="CUN60002"/>
        <property type="gene ID" value="ERS852478_00582"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025911">
        <property type="entry name" value="ToxN/AbiQ_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13958">
        <property type="entry name" value="ToxN_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN60002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="178" mass="20971" checksum="BE02A01A75F7CCB4" modified="2016-09-07" version="1">MNWYIVDKKYINYLTQFDSHVGYVEYGERLKLHVGTLLTIGNFHYYVPISSAKPKHQKMSNSLDFHKLQDESTRYLYAVLNINNMIPVPDNCLTQLKYNQIDCFRSFKSDKEKTDYIYLLQKEKFLIDNIQNTLQNKAMKLYQKCIAKPDSSLAARCCNFKMLEEKCLSYLHISPANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YA19</accession>
    <name>A0A173YA19_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nadC</name>
        <name evidence="13" type="ORF">ERS852478_00594</name>
        <name evidence="14" type="ORF">ERS852523_01829</name>
        <name evidence="15" type="ORF">GT728_05295</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 16">2789STDY5834863</strain>
            <strain evidence="14 17">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="15 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000016">
        <property type="protein sequence ID" value="CUP50387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000009">
        <property type="protein sequence ID" value="MZL32634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053023.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000022_gene1752"/>
    <dbReference type="EnsemblBacteria" id="CUN60420">
        <property type="protein sequence ID" value="CUN60420"/>
        <property type="gene ID" value="ERS852478_00594"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP50387">
        <property type="protein sequence ID" value="CUP50387"/>
        <property type="gene ID" value="ERS852523_01829"/>
    </dbReference>
    <dbReference type="GeneID" id="66492491"/>
    <dbReference type="eggNOG" id="COG0157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="12">
        <location>
            <begin position="23"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="11">
        <location>
            <begin position="113"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="242"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="263"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN60420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUP50387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL32634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="283" mass="30776" checksum="48ABBE96D318D98C" modified="2016-09-07" version="1">MNSITMKMQADKLIRMALQEDITSEDVSTNAVMRSAVKGTVDLIAKEDGIIAGLDVYARVFQILDEKTEISFNFKDGDAVKKGDLLGTVTGDIRVLLSGERVALNYLQRMSGIATYTKQVSKLLEGSKVTLLDTRKTTPNCRVFEKYAVRIGGGCNHRYNLSDGVLLKDNHIGAAGSVAKAVAMAKEYAPFVRKIEIEVETMEQVKEAVEAGADIIMLDNMTPEMMKEAVELIAGRAQTECSGNITKENIAKILETGVDFVSSGALTHSAPILDISMKNLHAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YD79</accession>
    <name>A0A173YD79_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">dTDP-Rha:alpha-D-GlcNAc-pyrophosphate polyprenol, alpha-3-L-rhamnosyltransferase</fullName>
            <ecNumber evidence="3">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">wbbL_2</name>
        <name evidence="3" type="ORF">ERS852478_00631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199725.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61759">
        <property type="protein sequence ID" value="CUN61759"/>
        <property type="gene ID" value="ERS852478_00631"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN61759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="318" mass="36440" checksum="27D688C4650DAD04" modified="2016-09-07" version="1">MQEVSVIIPNFNGMAYLDGVLAGLECQTVSNFDVILVDNGSNDGSCAFVAARYPWVHLIELPENFGFCKAVNEGIRASRSPYVLLLNNDIEVTENFIEEMLSAIKRHPKAFSCAARMIQFHDRDRLDDAGNYYCALGWAYARGKGKNIHTYEKEEKIFASCAGAAIYRKKIFDELGYFDEEHFAYLEDMDVGYRARIYGYENWYAPDAMVYHVGSGTSGSRYNQFKIRYSSRNNIYLIYKNMPVLQIIINLPFLVAGFGIKILFFTLKGFGREYIAGIKNGFQISKKNHKIPFKFQNLSNYFGIQVELWVNIFRRLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YQ65</accession>
    <name>A0A173YQ65_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division inhibitor MinD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">minD_2</name>
        <name evidence="3" type="synonym">minD_3</name>
        <name evidence="2" type="ORF">ERS852478_00723</name>
        <name evidence="3" type="ORF">ERS852523_00621</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN65710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP12312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055149516.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000016_gene3665"/>
    <dbReference type="EnsemblBacteria" id="CUN65710">
        <property type="protein sequence ID" value="CUN65710"/>
        <property type="gene ID" value="ERS852478_00723"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP12312">
        <property type="protein sequence ID" value="CUP12312"/>
        <property type="gene ID" value="ERS852523_00621"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014433">
        <property type="entry name" value="CooC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005647">
        <property type="entry name" value="CooC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN65710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP12312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="256" mass="27976" checksum="A3EF98176AA6FA08" modified="2016-09-07" version="1">MGHVIAVSGKGGVGKTTLCGLLIQYLCESGKRPVLAVDADANANLNEVLGVEPEVTLGELREEIERAGIDPRYQIPSGMTKQAYLEMRLSDAIAEEDDYDLMVMGRTQGQGCYCFVNGLVQTQVQKLQSHYPYIVVDNEAGMEHISRGILPMMEVAILVSDCSRRGVQAAGRIAKLMKELNFKPQKTGLIVNRVPNGKLDAGTLEEIRNQGLELLGVVPHDDQVYQYDCNGKPIIQLPKDSPVRSALGEIIKKLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YW80</accession>
    <name>A0A173YW80_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Purine nucleotide synthesis repressor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Putative HTH-type transcriptional repressor ExuR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purR_1</name>
        <name evidence="8" type="synonym">exuR</name>
        <name evidence="8" type="ORF">BWLFYP14_01746</name>
        <name evidence="5" type="ORF">ERS852478_00775</name>
        <name evidence="7" type="ORF">GT712_02885</name>
        <name evidence="6" type="ORF">GT728_04040</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">BIOML-A1</strain>
            <strain evidence="7 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059313.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67723">
        <property type="protein sequence ID" value="CUN67723"/>
        <property type="gene ID" value="ERS852478_00775"/>
    </dbReference>
    <dbReference type="GeneID" id="66493549"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN67723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL32388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS88056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX64918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="337" mass="37712" checksum="379B54700B9E3D7F" modified="2016-09-07" version="1">MVSMKDIAKQCNVSVASVSKALNGYSDISEETRQLILKTASEMGYLPNSSARALKTRRSYNLGVLFVDEAMSGLTHDYFNHVLESFKRTAESRGYDITFTSGNLSGQHLSYYEHCRYRGVDGVVIACINFFTEEVQRLVQSEIPVVTIDHVFDGRIAVVSNNIQGMEELVSYILERGHRKIAYIHGEDSSVTRNRLGSFYRTLQKKRIDIPDEYMPVIPYRDAEAAAIATSELLDLKDPPTCILYPDDFSALGGINEIHERGLRIPDDISIAGYDGLTFARILEPRLTTLCQDTETIGRLAAQKLIDLIENPKTTIIDKFTVDGRLFPGASVRNLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z1Y0</accession>
    <name>A0A173Z1Y0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199809.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69088">
        <property type="protein sequence ID" value="CUN69088"/>
        <property type="gene ID" value="ERS852478_00814"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN69088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="163" mass="18519" checksum="8D260DADF4F9B660" modified="2016-09-07" version="1">MDIVIREYQTEDVTAAITIWNQVVEDGVAFPQEENLTEETGDAFFEEQTYTGIAVNTDNNEIVGLYILHPNNVGRCGHICNASYAVRRDFRGEHIGEKLVLDCLAQAKENGFRVMQFNAVVANNTHALHLYERIGFTRLGVIPQGFRMPDGHYEDIIPHYYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z764</accession>
    <name>A0A173Z764_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00844</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199823.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71038">
        <property type="protein sequence ID" value="CUN71038"/>
        <property type="gene ID" value="ERS852478_00844"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="407"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN71038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="455" mass="52323" checksum="E8416326D59FD2BB" modified="2016-09-07" version="1">MIEVIYKDESQEGQNGEEPFGLPRNIRQIGLAAEDYRIYMEDYVYTFLVRLARTEDSLGEAKTRVAVLTGNLKWRSQTAYLFIKGAIIAEEMEAAPDHIDFSENQWKQIQEAQKEYFEDQEIVGWFFSQPQLLLKVSEVMSKVHMKHFGGEKVLMLMEPQEREDAFFRYENNEMVRLGGYYLYYEKNPGMQTYMIDKNEELQPEPQEKYEDQAVKDFRKIIADKKETRKEPAAPSVFSYGLTACLAIAVLTVGVNFYRSYQNVKQNEKESATVSSVIVEEITPSPVVGTSNNEAVRQHKQYRTDTIQNDAGKNKKNNEENDEENNQSTSEKENSEKKNNTSEKKISAEQTETEQKSDKTEQLPDVKTEKADKTEQIYQQEADERKAQKRVREAVQKENSEAAGKAHESYVIQPGDTLFQISMDRYGSIEAISQICKLNGMSADEIIYPGQVIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZCQ8</accession>
    <name>A0A173ZCQ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199846.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73246">
        <property type="protein sequence ID" value="CUN73246"/>
        <property type="gene ID" value="ERS852478_00923"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016770" evidence="1">
        <location>
            <begin position="24"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN73246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="392" mass="42299" checksum="68B6845B73995277" modified="2016-09-07" version="1">MKKLLAACVCAGLSFSFAGCSPETILEQFTSTGDTSVRELTSSSDTTTETETKDRIYMDELSGTLQDFSGSQLILNTDSTSYVFNVSNATLECKGGMITGDEISIIYEGQLSGTDTGSVHVLKVVDEFHKKNKLKKRTAHGQVISLTSNTITIKSKKGKTATYPITGTKQYYQNGIKAGDWVYLTFKGKFPDTSNDSSVSLNASHLKVLSISDLKDLEIPDPTPTPDPKLTQTPEQIENKEKQLLATVQGVNLNILRILPAGSDTSFNLDMSAIPAYFKGGIAPGSHVNVTYIGDLETTSLEEVRIIAVTGEDPDTINDKHISFTVTGTIIGSTANTITVQTDDGAIDTFRTENAQDLTASGMEYGDYVCVTFHPSKSKSSNIYTAIKVQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZEC7</accession>
    <name>A0A173ZEC7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase 2</fullName>
            <ecNumber evidence="2">3.1.1.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lip2_1</name>
        <name evidence="2" type="ORF">ERS852478_00962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74437">
        <property type="protein sequence ID" value="CUN74437"/>
        <property type="gene ID" value="ERS852478_00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triglyceride lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="78"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN74437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="316" mass="35793" checksum="3B62890E187EDB79" modified="2016-09-07" version="1">MISKTMKTILHTLSYGNIEVDSSRKLADLKQLDAMRIFVKKLDAKVYNGDHAVPIRLYFPTEEAMQAGIVEGNIFPILLFFHGGGWVTESVENYDRVCSRMAQATAHIVVSVEYRLAPEHKFPVPLEDCYAAAKALYSNELILNTDPEKITIVGDSAGGNLTAAVCLMARDRGDFTPKRQILIYPALGNCYTEESPYPSVHENGSDYLLTAVKMEDYLTLYQRTEEDRQNPYFAPILENNLKDLPETLVLTAEYDPLRDEGEAYAKNLEEAGNHVKLHRIHGAFHGFFALGIKFLHVQESFKYINEFLNKSYEKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZEJ6</accession>
    <name>A0A173ZEJ6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380930.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73545">
        <property type="protein sequence ID" value="CUN73545"/>
        <property type="gene ID" value="ERS852478_00933"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033RE4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN73545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="155" mass="17274" checksum="41B22D72DDC4EFFD" modified="2016-09-07" version="1">MKNKKERDWKFIIGMIVLLAIFAVMGGAFWNMVGKQAQIVREEEQKEEANAISAIYIETGEFLKTGVFVDLNNGTIFSADIPAEGIYNKKGKLISDDVLENGDKVKIYGDGIMLESFPGQYPGVTKIQRTGRASLEETQEYEDQVTGMMKPVAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZFF1</accession>
    <name>A0A173ZFF1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione import ATP-binding protein GsiA</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_4</name>
        <name evidence="6" type="ORF">ERS852478_00975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199863.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74827">
        <property type="protein sequence ID" value="CUN74827"/>
        <property type="gene ID" value="ERS852478_00975"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN74827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="337" mass="38423" checksum="44A80DC4748BEDB5" modified="2016-09-07" version="1">METEKKEVIFKIKNLKTWFPITKGFMKKVVGNVKAVDDVSIEVYKGETLGIVGESGCGKSTFGKTVMMLEKPTGGEVLFNYNGEYKDITKFNKDEMFEFRKKVQMVFQDPYSALNPQKKIYTSFEEPLKTHGVDSVEEREKIMNRVLKMVNIQPDYLMRFPHEFSGGQRQRLCIARALEVTPEVLICDEPVSALDVSIQAQVLNLMKEIQKELNLTYLFIAHDLSVVQYMSDRIMVMYLGKIVEVADSKALYDEPLHPYTKALLSAIPVADIHHKKKRQVLEGEVPSPIHKPSGCAFHNRCPYCMDICKKEDPVLRYHGADGHMTACHLYDGSEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZJW5</accession>
    <name>A0A173ZJW5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380841.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000060.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76501">
        <property type="protein sequence ID" value="CUN76501"/>
        <property type="gene ID" value="ERS852478_01025"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019271">
        <property type="entry name" value="DUF2284_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10050">
        <property type="entry name" value="DUF2284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN76501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="160" mass="17830" checksum="5BA2FE9DEA8ED3DD" modified="2016-09-07" version="1">MDLIKEALSMGFADAAIMDTKDLVFVPEYRQFCEDNLCGNYNLVPACPPACGTVEEMQAKALKYEKALVLQTVLKDPIMDPALFKQAKHAQNILTEQLARQMQEAGKEDILIMSAGPYKNCSCMSAYSVDAQKMADAVGMVCWADDSDVRFFTQILFHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZQK3</accession>
    <name>A0A173ZQK3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyn operon transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cynR_3</name>
        <name evidence="3" type="ORF">ERS852478_01055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052530.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78524">
        <property type="protein sequence ID" value="CUN78524"/>
        <property type="gene ID" value="ERS852478_01055"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN78524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="300" mass="34607" checksum="9A44B66C7ABAFC5D" modified="2016-09-07" version="1">MTLNQLRYFCTASRCHSITKAAEELYVTQPTVSVAIRDLEIEFGISLFYRKGNRLILTEEGEELYNKATYILQYCTELQADYSSMARVKPPLRIGIPPMLSTVFFPELLIAFHDQYPEIAVVLEEYGSVRACNLVQDDTLDLALVNMEQYNIDKFNKALLANDQVVFCVSDDHRLADKEVVTTKEMSKESLIFFNADSVQNQLLKTRFETDGYVPDIIMRSSQIYTILQLVKTCKYGSFLYSSMTDRFASSGIKGIPLSPPIRIKIGMIWKKGKYISDNMQKFLNFTKMYYREHPLIQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZV07</accession>
    <name>A0A173ZV07_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="6">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dus_1</name>
        <name evidence="9" type="ORF">ERS852478_01081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199914.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79459">
        <property type="protein sequence ID" value="CUN79459"/>
        <property type="gene ID" value="ERS852478_01081"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="5 6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="8">
        <location>
            <begin position="5"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN79459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="326" mass="37608" checksum="D79F1A7AFB9C8930" modified="2016-09-07" version="1">MKIYLAPLEGITGYTYRRALYNCFGGFDKYFIPFILPNQKGHLSTREKKDIMPENNEGMYAVPQILTKNAEDFIQTAETLQEYGYNEVNLNLGCPSKTVVTKGRGAGFLDRPDELDKFLDEIFRKCDMKISIKTRLGMDDPEEFEDLLTIYNKYPLEELIVHARVQKDYYKNKPRLETFGEAVEHSKSPVCYNGDIVTAEDCTRLQEMFPTLDCIMTGRGTLKNPALAREIRGGAPASKEEIRRFHDMMYNEYGEDLSGDRNILFRMKELWSYLAPMFTNNKKYAKKIKKAEKCVVYENAVRELFGCEQLIGEVENADMEKNTGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A6R4</accession>
    <name>A0A174A6R4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-galactosyl-beta-1-&gt;3-N-acetyl-D-hexosamine phosphorylase Cphy0577</fullName>
            <ecNumber evidence="4">2.4.1.211</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.211" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN84331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84331">
        <property type="protein sequence ID" value="CUN84331"/>
        <property type="gene ID" value="ERS852478_01217"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050500">
        <property type="term" value="F:1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035080">
        <property type="entry name" value="Lact_bio_phlase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012711">
        <property type="entry name" value="Lacto-N-biose_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035356">
        <property type="entry name" value="LBP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035363">
        <property type="entry name" value="LBP_M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09508">
        <property type="entry name" value="Lact_bio_phlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17386">
        <property type="entry name" value="LBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17385">
        <property type="entry name" value="LBP_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02336">
        <property type="entry name" value="TIGR02336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lact_bio_phlase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="LBP_M" evidence="2">
        <location>
            <begin position="439"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="LBP_C" evidence="3">
        <location>
            <begin position="664"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN84331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="718" mass="83600" checksum="756EAD21FD4272DD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AFF9</accession>
    <name>A0A174AFF9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199994.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87124">
        <property type="protein sequence ID" value="CUN87124"/>
        <property type="gene ID" value="ERS852478_01265"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9RA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN87124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="235" mass="27658" checksum="4D75DC8241A1CF8E" modified="2016-09-07" version="1">MSNEIRTRPLTPTEQKYTYAQSMQLEGQTGTIGHLRGDFATTGYGFYTTWFDTRPQWKSDEFKADLDTVINALREDKGLLHNRYDMSAFARHFPESAIKGNYCTEYGFRVDTEKHAFLLRCNPTKGDYNFYCYCYVKEWLDKHIQKAEQGIRFIDPQYKELFRIPDGGKVIVTTSWGEKREYPCRFIDEYHTEVGSNLYHICEFAERMQKNGATYEPKSAEQTPQKTPKHKDLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AQK0</accession>
    <name>A0A174AQK0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ferrous-iron efflux pump FieF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fieF</name>
        <name evidence="9" type="ORF">ERS852478_01354</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90149">
        <property type="protein sequence ID" value="CUN90149"/>
        <property type="gene ID" value="ERS852478_01354"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="8">
        <location>
            <begin position="240"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN90149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="319" mass="34293" checksum="240C8483E94C15C8" modified="2016-09-07" version="1">MEQTKKLNMTAMSDKTNSNTTAKKEEPAWEHKVAMKVSGVSIAVNLLLSLFKLLAGILAHSGAMISDAIHSASDVGSTFVVIVGVNLSSKKSDKEHQYGHERMECVSSIILSGLLLATGIGIGMNGIENIIKSTSGASIAIPGTLALIAAVVSIVVKEWMFWYTRSAAKKINSGALMADAWHHRSDAMSSVGAFIGILGARLGFPILDPIASVAICVLIVKASVDIFRDAIDKMVDHSCDEATEESMREVIMGVKGVKGIDLLQTRLFGSKMYVDIEISADGEIPLNEAHDVAENVHHTIEKNFKDVKHCMVHVNPVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ASN6</accession>
    <name>A0A174ASN6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized HTH-type transcriptional regulator ybbH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ybbH_2</name>
        <name evidence="3" type="ORF">ERS852478_01383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN91203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379841.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91203">
        <property type="protein sequence ID" value="CUN91203"/>
        <property type="gene ID" value="ERS852478_01383"/>
    </dbReference>
    <dbReference type="GeneID" id="66494867"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51071">
        <property type="entry name" value="HTH_RPIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="122"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN91203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="280" mass="31343" checksum="26C524267C48E53B" modified="2016-09-07" version="1">MNDLFVRIRFLLPSLPRAEKAIASALLENPEAITHLTLAEIARESGSSEASIIRFCKRMGYDGYSSMKEDFIRALAEGMEIHSEDIKVSDDMKTILKKVYQSNVQMLSDTLVLADDENYEKALDALLKAREIHFFGVGDAFAVCQLAYMKFGRLGIPCSVHSDVMLQMMTAGNLTSEDVALAVSYEGRSRNVVEAMKIAKERGAVTISITKMNKSPLLRYTDISLFTAVNDLTVGRDKVTRRVSDQFILDALYLGYTTKINKGYKKQLQKIQTVIDCNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ATY6</accession>
    <name>A0A174ATY6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-xylulose 5-phosphate 3-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060590.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90946">
        <property type="protein sequence ID" value="CUN90946"/>
        <property type="gene ID" value="ERS852478_01376"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN90946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="275" mass="31410" checksum="FE773E76C9D5423F" modified="2016-09-07" version="1">MEKKIKFGCVAWGLPGGGYFGPQIAKEAGLDGIQLELGSYEWGYPLAQKQVQEAYLEEGNRLGIEYPSIVLNDVMDHEFIHGKDTENGKIAYDQMELAVQVAAEIGISKIMVPNFLGNLITEESHVEATKDALRFICEKAEKKDITVMTENALDYKEQIQLLKEINMPNLTIHFDTQNFRFNFNMDQCEQLEGLYPYMDSQLHVKDGINEPGGCLLGEGNTDFFPQMEILKKHGYEGWIIIENYYNLLPLRKCNEQNQMQIINKDLETLRTVWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AXX6</accession>
    <name>A0A174AXX6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200061.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93013">
        <property type="protein sequence ID" value="CUN93013"/>
        <property type="gene ID" value="ERS852478_01404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025586">
        <property type="entry name" value="PcfJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14284">
        <property type="entry name" value="PcfJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="578"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN93013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="720" mass="85229" checksum="B56C8607254F8E0D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B4T8</accession>
    <name>A0A174B4T8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative amidoligase enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200118.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95413">
        <property type="protein sequence ID" value="CUN95413"/>
        <property type="gene ID" value="ERS852478_01479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN95413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="308" mass="35545" checksum="F3D32932E5A1AEFC" modified="2016-09-07" version="1">MSELLKKQKFGVEVEFTGITRTMAAEAVAEILGSHAAGPDRTCYRTYTIRDSKRRIWKVMRDSSICPVRKAGRELMDEYRVEFVTPPLNYEDIETLQTIIRKFKELGGVPHSSCGIHIHVDGANHTATSLRRLVNFFFSRQEIIYDALAVGNRKDRWCRPVCKDLLDTMKKEKDLDTRKVEEIWYSSANDQYHGGIDHSHYNSTRYHALNLHSFFQKGTVEFRLFNSTLHAGKIKAYIQFVLALSAWSIESSDKIVFRSMNGYTAEKKVTLMYNILTNRLGLYGDEFKTCRLHMMKQLRKNAEASHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B4U4</accession>
    <name>A0A174B4U4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200102.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94756">
        <property type="protein sequence ID" value="CUN94756"/>
        <property type="gene ID" value="ERS852478_01459"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN94756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="176" mass="18125" checksum="013A5D9E460E2D65" modified="2016-09-07" version="1">MISAERLVELRAKVKKEMARRSCVEHGSSASMNKFAANYDYNVVPVTGGDITDEHIQKVIDPLLNVADFLQNNSLQQSHSGADVIVDQAEKFVDTLAKIDKQASDSGCRGLCTGLCVGSCTSGCQGCTGCTGGCDTTCAKSCSDGCSTSCGGCSDGCFSGCTHTCGSGCTTGAMTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B5I6</accession>
    <name>A0A174B5I6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200109.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95006">
        <property type="protein sequence ID" value="CUN95006"/>
        <property type="gene ID" value="ERS852478_01466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN95006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="114" mass="13461" checksum="2DB8FC338448C957" modified="2016-09-07" version="1">MQKAKYMERQPEVRWQPVNNGMVDVTLCLNEQKVTIEQGQMEDSAKQMMYEYDYHQFRESADKINEETVRASPAKYMSYVPEVEKSLEEQFEELKASNEMLTGCVLEMSELVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B6R9</accession>
    <name>A0A174B6R9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200116.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95325">
        <property type="protein sequence ID" value="CUN95325"/>
        <property type="gene ID" value="ERS852478_01476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN95325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="140" mass="16666" checksum="4A7D9A21584088DF" modified="2016-09-07" version="1">MKKYNLSKIMKRAWELVKKSAMTISSGLKKAWEEAKTMVNYALEVFDNQKGYKIPWKELEKMLDTVYPDGDQGNGWYQKWNCNDWVKGGKDRTYISLREYRNSKLRAEHALGYYDNINGVYVITDRYKKVTDVIEKFQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B9A7</accession>
    <name>A0A174B9A7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">topB_2</name>
        <name evidence="12" type="ORF">ERS852478_01536</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97581">
        <property type="protein sequence ID" value="CUN97581"/>
        <property type="gene ID" value="ERS852478_01536"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN97581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="488" mass="54646" checksum="839DDA278708DA14" modified="2016-09-07" version="1">MSYQLVIAEKPSVARSIAGVIGADKKQDGYMEGNGYLVSWCIGHLVSLADAGTYDERFKKWRYDDLPILPQEWQYIIPDDKKKQFDTLRSLMERPDVTGLVCATDAGREGELIFRFVYRMAGCKKPFQRLWISSMEDAAIKDGFAHLKPGTDYDNLYQSALCRAQADWLVGINATRLFSILYHKTLTVGRVQTPTLKMLVDREAKISSFQKEKYHIVQIAAGGMEAASERMGNADDAKALKAACETAQAVCVSVTREKKTEQPPRLYDLTTLQREANRLFGFTAKQTLDYAQQLYEKKLLTYPRTDSQYLTDDMLPTAESLVSGLWPLLPFAAGLDLSPQFGRVLNSKKVSDHHAIVPTMEFVQKGFDGLAEGEKKLLSLVCCKLLCAVAAPHVYEAVTATFTCAGKTFTAKGKTILTPGWKELDRRFKASFKTDADDTAPELARELLEITEGQTFDKVTATVTEHFTAPPKSYTEVICYERGIRNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BB70</accession>
    <name>A0A174BB70_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spo0A_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN98261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009319960.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000117.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98261">
        <property type="protein sequence ID" value="CUN98261"/>
        <property type="gene ID" value="ERS852478_01557"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042173">
        <property type="term" value="P:regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014879">
        <property type="entry name" value="Spo0A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08769">
        <property type="entry name" value="Spo0A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spo0A_C" evidence="2">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN98261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="74" mass="8712" checksum="07D98D8E05FC8DD1" modified="2016-09-07" version="1">MLRFRKKDSKELIKRMAKTNGCSVSEIRREMQYAIDEARNSDDPNKQAEFQRLFGNKIPSPEEFICVVSKNLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BDS6</accession>
    <name>A0A174BDS6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF3847)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200135.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97778">
        <property type="protein sequence ID" value="CUN97778"/>
        <property type="gene ID" value="ERS852478_01542"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024215">
        <property type="entry name" value="DUF3847"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12958">
        <property type="entry name" value="DUF3847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN97778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="97" mass="11482" checksum="DF17EF299B9B07E7" modified="2016-09-07" version="1">MTKPREKTREELQAEIEDGKKKIRQFENREKMLRQKLSKEERRTRSHRLIVRGAVFESIVPEAKDMTDEEAAALLRLALTSEPVREFLRKRAEETTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BG43</accession>
    <name>A0A174BG43_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008371496.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00001">
        <property type="protein sequence ID" value="CUO00001"/>
        <property type="gene ID" value="ERS852478_01583"/>
    </dbReference>
    <dbReference type="GeneID" id="43514312"/>
    <dbReference type="GeneID" id="64113512"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO00001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="130" mass="15078" checksum="8B3A00F21C46A42E" modified="2016-09-07" version="1">MVSVDQAYMVEHMKNADGSINNKNVVLSAACEAAELFQCMMSVNQKLEDWQRFNHTLEMHLRSVECEKIHDICQAVYGMKHPSNELEGLYLAREDEQICLLYYQVFVGMLEININSAEVLYKQKEEIINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BS22</accession>
    <name>A0A174BS22_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HTH-type transcriptional activator CmpR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cmpR</name>
        <name evidence="6" type="synonym">cmpR_1</name>
        <name evidence="6" type="ORF">BWLFYP14_00293</name>
        <name evidence="3" type="ORF">ERS852478_01695</name>
        <name evidence="5" type="ORF">GT712_08795</name>
        <name evidence="4" type="ORF">GT728_04885</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">BIOML-A1</strain>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707308.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03901">
        <property type="protein sequence ID" value="CUO03901"/>
        <property type="gene ID" value="ERS852478_01695"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO03901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX67452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="292" mass="33075" checksum="0187F0881B8AAFD0" modified="2016-09-07" version="1">MDINLELYKVFYYVATTLSFSEASRQLFISQSAVSQSIKTLEKKLNHPLFIRSTKKVLLTPEGELLLQHVKPALQLLDEGESLLSGDNLLKGQLRIAASDTICRYFLIDYLQKFHQTYPDVRIKVTNSTSIGCAELLEKGQADLIVCNCPNSRLGSHFQTRVLKEFHDVFVANTDYFPVHTVQTELQELLNYPILMLSPKSTTSEYLREAFTAHNLKLLPEVELNSNDLLLDLARIGLGIACVPDYMLKENDQLTPLMLKEPLPGRQLILAQHDSLTVSQAAERFIEMFTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BZ78</accession>
    <name>A0A174BZ78_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO04945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009247529.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO04945">
        <property type="protein sequence ID" value="CUO04945"/>
        <property type="gene ID" value="ERS852478_01706"/>
    </dbReference>
    <dbReference type="GeneID" id="61850130"/>
    <dbReference type="GeneID" id="66882340"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO04945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="176" mass="20316" checksum="02D287FC259DE4C6" modified="2016-09-07" version="1">MAISERIHFFRLMRGMTQKYLGTAIGFPEKSADVRLAQYETGTRKPKADLTNALAQVLDVSPQALDVPDIDSYIGLMHTLFTLEDIYGLTVSEADGEVCLKVNKDKGREAYELLKMLYAWKEQADKLSSEEINREEYDNWRYHYPEFDTTQRWAKVPSQELSDALVEAFKDHLKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C465</accession>
    <name>A0A174C465_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stalked cell differentiation-controlling protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pleD</name>
        <name evidence="4" type="ORF">ERS852478_01772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200251.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07079">
        <property type="protein sequence ID" value="CUO07079"/>
        <property type="gene ID" value="ERS852478_01772"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="401"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="487"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO07079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="626" mass="71347" checksum="3C2BA70DDFDDCF78" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CCS6</accession>
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        <submittedName>
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        </submittedName>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">2789STDY5834863</strain>
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        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO10974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="192" mass="22278" checksum="9B76BF8BCCC98AE3" modified="2016-09-07" version="1">MKAKHWYDYLWVYAIIYFALGFFNILFAWLGMIDFLLPLFLAIFGGNKFFCNHLCGRGQLFSKLGTDLKCSRCKPTPRWMSSKWFRYGFLLFFLTMFGNMVFQTYLVAAGAASLREAVKLFWTFRVPWSWTYTAGTVSDWVAQFSFGLYGLMLTSLLLGLIVMVLYKPRTWCAFCPMGTMTLGICKLKNKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CDF8</accession>
    <name>A0A174CDF8_9FIRM</name>
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            <end position="221"/>
        </location>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0004540">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO10350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="214" mass="25242" checksum="68464EF292C1B7EA" modified="2016-09-07" version="1">MHKVMVFIDYQNFFISWKWKNRGKKPPAIDYKKLGRLINRQIPLDSEVIKTYLFAYKPCDELMLLEPYQRYYNWLNGMKKTPYLEVIEGRQDIHRIHGVEFDINDPSTYTTEEKETDINIATHMIAKGFQNAYDIAILVSGDTDYVQVIRTLHDLGKIVVIAHFPEQNIAKYQGMYDAEVILDDDLLHRAGNASYGREKRSRKRYPSRFPSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CNS2</accession>
    <name>A0A174CNS2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_02186</name>
        <name evidence="1" type="ORF">ERS852478_01947</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
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            <taxon>Lachnospiraceae</taxon>
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        </lineage>
    </organism>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CUO13306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13306">
        <property type="protein sequence ID" value="CUO13306"/>
        <property type="gene ID" value="ERS852478_01947"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO13306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX65821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="57" mass="6667" checksum="6128AD0C7CBEF48F" modified="2016-09-07" version="1">MIILNKEHREIYSREVTREIPNSETISAINEVQQMKQNPSLGKSYTDIDKMMIDLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CP34</accession>
    <name>A0A174CP34_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multidrug export protein mepA</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">mepA_9</name>
        <name evidence="3" type="ORF">ERS852478_01985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707523.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15271">
        <property type="protein sequence ID" value="CUO15271"/>
        <property type="gene ID" value="ERS852478_01985"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019361" evidence="2">
        <location>
            <begin position="20"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO15271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="445" mass="48357" checksum="4FF4FF8DE2A5FF94" modified="2016-09-07" version="1">MNNTFMKKKPILPLLASMAMPMVLSMLVNSLYNIVDSFFVAKISEQAMTALSLVFPVQNFINAVAIGFGVGINAQISFQLGAKNIKNANIAATHGMLFNIIHGIIFTVICIPFMPVFLSMFTKAQEVISSGVQYSTIAFAFSTVIMISLSFEKIFQAVGRMKLTMISLMIGCISNIILDPLLIFGVGIFPEMGIRGAALATGLGQVFTVIVYLIAYKKCSIPVEISRKYLELNRNLDGKLYMVGIPAILNIALPSVLISFLNQILSAFSGSYVVVLGIYYKLQTFLYLPASGIVQGMRPLIGYNYGAGEIKRVKKLFGISVLLNGMIMLAGTIICFTASETLMGMFTENPETVRLGTAALQIISIGFIPSAISVTASGALEGLSKGAQSLVISLLRYIIVIIPAAYLLCYFAGADAVWNAFWICEFITAVVVGIGIKYYWNRLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CSZ2</accession>
    <name>A0A174CSZ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <ecNumber evidence="5">3.6.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dut</name>
        <name evidence="8" type="ORF">BWLFYP14_00435</name>
        <name evidence="5" type="ORF">ERS852478_02015</name>
        <name evidence="7" type="ORF">GT712_10230</name>
        <name evidence="6" type="ORF">GT728_08855</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 12">BIOML-A1</strain>
            <strain evidence="7 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000018">
        <property type="protein sequence ID" value="MZS89435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707572.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16264">
        <property type="protein sequence ID" value="CUO16264"/>
        <property type="gene ID" value="ERS852478_02015"/>
    </dbReference>
    <dbReference type="GeneID" id="66495635"/>
    <dbReference type="eggNOG" id="COG0756">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="4">
        <location>
            <begin position="38"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO16264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL33301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS89435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX62352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="170" mass="19129" checksum="BE309F2543D16751" modified="2016-09-07" version="1">MKRIAKFHKVSKERFTADWIDTFAQSQEEAEKVYEAIRLPKRATAGSAGYDFFAPAEFTLKPGETVKIPTGIRVEMQPEWVLKCYPRSGLGFKYRLQLNNTVGIIDSDYFYSDNEGHIFSKITNDSNENKTLTIPADTGFMQGIFVEYGITVDDDATEIRNGGFGSTTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CV41</accession>
    <name>A0A174CV41_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">accB_2</name>
        <name evidence="6" type="ORF">ERS852478_01998</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707550.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15690">
        <property type="protein sequence ID" value="CUO15690"/>
        <property type="gene ID" value="ERS852478_01998"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00531">
        <property type="entry name" value="BCCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="67"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO15690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="145" mass="15950" checksum="252442920F8D0297" modified="2016-09-07" version="1">MDLEKIEGLVKIIEDSSLNEFTYKDKDVKITMSKLDHPPVVAAGVPVAASAPVNTIVEKAEEEEEESLFITSPIVGTFYSASAPDVPAFVKVGDQVKAGQTVCILEAMKLMNEIQSDYDCEIEAVLVSNEQKVEYGQPLFRVKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D531</accession>
    <name>A0A174D531_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060223.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20553">
        <property type="protein sequence ID" value="CUO20553"/>
        <property type="gene ID" value="ERS852478_02133"/>
    </dbReference>
    <dbReference type="GeneID" id="66495352"/>
    <dbReference type="eggNOG" id="ENOG5032RBW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO20553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="98" mass="11180" checksum="FFCCDAEF7E742642" modified="2016-09-07" version="1">MFILKFAGKILLLPVWLILFVIGLAVKMTVQTYAVVRGILGFIFTLLIIATAYCYHDWVQVAFLFSLSVILYLILFAGVFVDTVLDMTRERLIDFIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D6S1</accession>
    <name>A0A174D6S1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable endopeptidase p60</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">iap_3</name>
        <name evidence="4" type="ORF">ERS852478_02157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200589.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21321">
        <property type="protein sequence ID" value="CUO21321"/>
        <property type="gene ID" value="ERS852478_02157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="211"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO21321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="335" mass="37022" checksum="24467F6DC6DC220D" modified="2016-09-07" version="1">MRLKRILIIGTIFPVLFSIVLFFGILISGEDDDSSNSYSPVYSGMNLSADVLKHQPMVEKYARENGISEYVNVLLAIIQVESGGTATDVMQSSESLGLPPNSLSTEESIKQGCKYFASLLSSCKAKGMNDINVVIQSYNYGGGYTDYVAKNGKKHSFNLAENFAKNKSGGTKVTYTNPIAVSKNGGWRYNYGNMFYVELVNQYLTVKQFSNETVQAVMNEALKYQGWKYVYGGSNPNTSFDCSGLTQWCYGKAGISLPRTAQAQYDATQHIPLSQAQAGDLVFFHSTYNTSDYVTHVGIYVGNNQMYHAGNPIGYTDLTSAYWQQHIICAGRIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7X4</accession>
    <name>A0A174D7X4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20118">
        <property type="protein sequence ID" value="CUO20118"/>
        <property type="gene ID" value="ERS852478_02119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO20118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="49" mass="5742" checksum="B09B568068727103" modified="2016-09-07" version="1">MANDITVKHGWILLLFVSLYITKRSETVLQWGKRKNIKKLMINGELVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D8P5</accession>
    <name>A0A174D8P5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sporulation initiation inhibitor protein soj</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">soj_4</name>
        <name evidence="2" type="ORF">ERS852478_02174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379905.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21823">
        <property type="protein sequence ID" value="CUO21823"/>
        <property type="gene ID" value="ERS852478_02174"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO21823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="255" mass="28124" checksum="CCF42CD02961C0A9" modified="2016-09-07" version="1">MGRIVAVANQKGGVGKSTTAINLSACLAEKGKKVLTIDIDPQGNTTSGLGVDKNSVENTLYELLLGEAETKDTIVKDVVENVDLIPSNINLSGAEIELVGIDNKEFILKGITDKLRRKYDYIIMDCPPSLNMLTINALTAATSVLVPIQCEYYALEGLSQLIHTIDLVRDRLNKRLKIEGVVFTMYDARTNLSLQVVENVKENLNQNIYKTIIPRNVRLAEAPSYGQPITIYDPRSAGAESYRLLAEEVLNREDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DG44</accession>
    <name>A0A174DG44_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor, sigma-70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200633.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24454">
        <property type="protein sequence ID" value="CUO24454"/>
        <property type="gene ID" value="ERS852478_02243"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="79"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO24454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="139" mass="16453" checksum="9D2C19AC693116C0" modified="2016-09-07" version="1">MKPSDFQKTIQCQFESKLKKIVKGIVKNYQKELKRRKKKEISFCELPEVVIENLAVLDDYEADYTLFSVCGIDIRILDDELAEALKKLSDRNRENLLMYYFLEMSDTEIAKLQNISRSGVFQNRYNSLELMKKILKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DIA7</accession>
    <name>A0A174DIA7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">purD</name>
        <name evidence="11" type="ORF">ERS852478_02224</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO23928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705481.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23928">
        <property type="protein sequence ID" value="CUO23928"/>
        <property type="gene ID" value="ERS852478_02224"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GARS_C"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="107"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO23928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="424" mass="46551" checksum="311F9AC20A53F701" modified="2016-09-07" version="1">MKVLIVGSGGREHAIAWSVSKSPKVDKIYCAPGNAGIAELAECVDIGAMEFEKLADFAQEKEIDLTIIGMDDPLVGGVVDVFEARGLKVFGPRKNAAILEGSKAFSKDLMKKYNIPTAAYENFDDPEKALEYLRTEARFPIVLKADGLALGKGVLICKDLKEAEDGVKEIMEDKKFGNAGNTMVIEEFMTGREVSVLSFVDGKTIRTMTSAQDHKRAQDGDQGLNTGGMGTFSPSPFYTEEVDEFCRKYVYQPTVDAMAAEGRPFKGIIFFGLMLTPDGPKVLEYNARFGDPEAQVVLPRMKNDIIEVMEACVNGTLDQIDLQFEDNAAVCVVLASDGYPVKYEKGIPMYGFENFKGKDGYYCFHAGTKLKDGQIVTNGGRVLGITATGKDLKEARKNAYEATEWITFANKYMRHDIGKAIDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DR39</accession>
    <name>A0A174DR39_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ypdA_3</name>
        <name evidence="16" type="synonym">ypdA_4</name>
        <name evidence="16" type="ORF">BWLFYP14_01549</name>
        <name evidence="15" type="ORF">ERS852478_02303</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380184.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26350">
        <property type="protein sequence ID" value="CUO26350"/>
        <property type="gene ID" value="ERS852478_02303"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="327"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="401"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO26350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VUX64695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="601" mass="68155" checksum="A7586EBFC867192F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E4E0</accession>
    <name>A0A174E4E0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase IS200 like protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Transposase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02146</name>
        <name evidence="2" type="ORF">ERS852478_02474</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32623">
        <property type="protein sequence ID" value="CUO32623"/>
        <property type="gene ID" value="ERS852478_02474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="16"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO32623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="139" mass="16506" checksum="608108D5700FB05D" modified="2016-09-07" version="1">MFNINNNELSYGRGYVYSLQYHLVWCTKYRKKVLKDGIDTECKEMLCDLAEEYKFQILAMEVMPDHIHLLVDCRPQFYISDMIKIMKGNIARQMFLAHPELKKELWGGHLWNPSYCAVTVSDRSREQVCSYIEGQKERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E990</accession>
    <name>A0A174E990_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32865">
        <property type="protein sequence ID" value="CUO32865"/>
        <property type="gene ID" value="ERS852478_02484"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030R6U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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            <end position="26"/>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO32865.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="144" mass="15809" checksum="EFBBADFC87AF9D74" modified="2016-09-07" version="1">MKKKVTIVLVIISIVAISTMIMFSTYKSSEACRKANAAIQWDCSVTCAEESTPDSYVITYSDAKILSKTGVLTVQNRNDFDVIVHLLCEGKQELVSGSIPAGGCYSFLNVTDKEYTVGIHADVGENTDIKVFVYDGKDTESYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
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                <person name="Raman A."/>
                <person name="Venkatesh S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
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    </evidence>
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    <gene>
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        <name evidence="10" type="synonym">cooS</name>
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        <name type="scientific">Blautia wexlerae</name>
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            <taxon>Bacteria</taxon>
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    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
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            </authorList>
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            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
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                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
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            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:21040"/>
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        </reaction>
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    <comment type="cofactor">
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            <dbReference type="ChEBI" id="CHEBI:49883"/>
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    </dbReference>
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        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR004137">
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        <property type="entry name" value="Prismane-like_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0533">Nickel</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
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        <location>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
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        <location>
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        <ligand>
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        <ligand>
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        <ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR005023"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="630" mass="67990" checksum="68671C7A95E858F1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EK91</accession>
    <name>A0A174EK91_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ktr system potassium uptake protein B</fullName>
        </submittedName>
        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="9" type="ORF">BWLFYP14_00911</name>
        <name evidence="8" type="ORF">ERS852478_02648</name>
    </gene>
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        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
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            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
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        </lineage>
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    <reference evidence="8 10" key="1">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38382">
        <property type="protein sequence ID" value="CUO38382"/>
        <property type="gene ID" value="ERS852478_02648"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO38382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX63433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="464" mass="50385" checksum="9EC2AE60D7FEF219" modified="2016-09-07" version="1">MNKKMQLYNRLHKLNTAQIITLGFAGVIILGGLLLWLPFCTAPGYHTSFTDAMFTATTSICVTGLVTVVTATHWTLAGKIIILVLIQIGGVGLISLGSIIFISLRKKISLRNRRVIQESYNMDRMGGMVRLVKKVLICVFGAEGIGAVCYAVRFIPQFGLAKGLGYSVFTAVSAFCNAGIDLLGEDSLAQYVADPIVNFTSVGLIIMSGLGFVVWWDIWDKIKRVIRGKLPVGRIFKNLRLHSKIVLMMTLILVVGGTVLIFLFDHGNPESIGTYSPGTKWMASLFQSVTTRTAGFFTVSQERFSNATYMLCLVLMLIGGSPMGTAGGIKTTTVAVLLLSLKSNLQGKRDVEVHHRRIRDSYIRSAIVVTGMVLTVLILMSMLLCAAMPEAPIEDVVYEITSAVATVGLSRGLTPCLNTAGKWIVILTMYLGRIGPLTLGTAVTVRVQKMPADSHLAEEDIMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EQB2</accession>
    <name>A0A174EQB2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pncB2</name>
        <name evidence="12" type="ORF">ERS852478_02663</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200816.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO38858">
        <property type="protein sequence ID" value="CUO38858"/>
        <property type="gene ID" value="ERS852478_02663"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="10">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="9">
        <location>
            <begin position="152"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase_C" evidence="11">
        <location>
            <begin position="363"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO38858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="487" mass="54712" checksum="2DA5F95D6A990B88" modified="2016-09-07" version="1">MRANNLTLLTDLYELTMMQGYFKNPTNQTVIFDMFYRTNPCGGAFAITAGLEQMIEYIENLKFTNEDIKYLRSLNIFEEDFLEYLSNFRFTGDIYAIPEGTVVFPREPLVKVVAPIMEAQLVETAILNIINHQSLIATKAARVCYAAKGDAIMEFGLRRAQGPDAGIFGARAAIIGGCAGTSCVLTGKMFDVPVLGTHAHSWIMSFPDEYTAFKTYAKLYPNACTLLVDTYDVLKSGVPNAIRVFEEMREEGIPLTKYGIRIDSGDLAYLSKEAYKMLAAAGFDDAVISASSDLDEYLIESLKAQDAKINSWGVGTRLITANDNPAFGGVYKLAAVKDADSTEFTPKIKLSENTEKVTNPGNKTVYRLYNKKTGKIRADLICLADEKLDADQNMVLFDPIDTWKKTKVLGGTYEVRELLVPVIREGKRVYESPSVMELREYCQKEQNTLWDESRRFVNPQKVYVDLSQKLWDLKKDLLEEMSEKALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F340</accession>
    <name>A0A174F340_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucokinase</fullName>
            <ecNumber evidence="2">2.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glucose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glcK</name>
        <name evidence="9" type="ORF">BWLFYP14_02886</name>
        <name evidence="5" type="ORF">ERS852478_02839</name>
        <name evidence="6" type="ORF">ERS852523_03595</name>
        <name evidence="8" type="ORF">GT712_17595</name>
        <name evidence="7" type="ORF">GT728_14475</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000056">
        <property type="protein sequence ID" value="CUQ00745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000038">
        <property type="protein sequence ID" value="MZL34372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000052">
        <property type="protein sequence ID" value="MZS90822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000064">
        <property type="protein sequence ID" value="VUX66509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379920.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000066_gene3227"/>
    <dbReference type="EnsemblBacteria" id="CUO44643">
        <property type="protein sequence ID" value="CUO44643"/>
        <property type="gene ID" value="ERS852478_02839"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ00745">
        <property type="protein sequence ID" value="CUQ00745"/>
        <property type="gene ID" value="ERS852523_03595"/>
    </dbReference>
    <dbReference type="GeneID" id="66494770"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004654">
        <property type="entry name" value="ROK_glcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00744">
        <property type="entry name" value="ROK_glcA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO44643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUQ00745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL34372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS90822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="314" mass="32667" checksum="5763147BAD8E83F6" modified="2016-09-07" version="1">MGKYCFGIDVGGTSVKCGLFQTDGVLVEKWEIPTRKENSGEAILPDIAKTILDKIAERKLDKEEIDGVGIGVPGPVNERGEVPCAVNLFWGFKEVTKELTELTGLPSKAGNDANVAALGEAWKGAAAGAKNVILVTLGTGVGGGIIVDGKIVGGAHGAGGEIGHAAVDHEEKEACNCGNCGCLEQYASATGIVRVAQRTLAATDEQTVLRKFTKLSAKNVLDAFKEGDKVACDVMAQVGEMLGGTLAMFACVTDPEAIVIGGGVSKAGQPLIDCIQKYYEKYAFTACKKTPIILATLGNDAGIYGSARMVIKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F3D2</accession>
    <name>A0A174F3D2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF3783 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Domain of uncharacterized function (DUF3783)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_01047</name>
        <name evidence="1" type="ORF">ERS852478_02800</name>
        <name evidence="2" type="ORF">GT712_15290</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000036">
        <property type="protein sequence ID" value="MZS90396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200934.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43316">
        <property type="protein sequence ID" value="CUO43316"/>
        <property type="gene ID" value="ERS852478_02800"/>
    </dbReference>
    <dbReference type="GeneID" id="66494732"/>
    <dbReference type="eggNOG" id="ENOG5033FK0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016621">
        <property type="entry name" value="UCP014543"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12646">
        <property type="entry name" value="DUF3783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO43316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS90396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX63682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="127" mass="14772" checksum="DFEB68C268214F1E" modified="2016-09-07" version="1">MKPTILLINFQDQQKLRKLKMALLPFKLRIKTIEPQDYSQPIGYLAGVKEISQVQIPSALIPQEQMEKEMLILAGITGNLFDQVLYTLRKAGTPVDYKAVLTEHNQNWNCMQLYKELEKEHNMYHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F8X5</accession>
    <name>A0A174F8X5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vegetative protein 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fusA_2</name>
        <name evidence="8" type="ORF">ERS852478_02864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200976.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45266">
        <property type="protein sequence ID" value="CUO45266"/>
        <property type="gene ID" value="ERS852478_02864"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03711">
        <property type="entry name" value="Tet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010298">
        <property type="entry name" value="DUF901"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035650">
        <property type="entry name" value="Tet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05991">
        <property type="entry name" value="NYN_YacP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="670"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="674"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO45266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="920" mass="104784" checksum="2576FE3D899906C8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FFB8</accession>
    <name>A0A174FFB8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="9">HTPA reductase</shortName>
            <ecNumber evidence="9">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">dapB</name>
        <name evidence="12" type="ORF">ERS852478_02976</name>
        <name evidence="13" type="ORF">GT728_07420</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 14">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000013">
        <property type="protein sequence ID" value="MZL33035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706259.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48894">
        <property type="protein sequence ID" value="CUO48894"/>
        <property type="gene ID" value="ERS852478_02976"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="10">
        <location>
            <begin position="2"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="DapB_C" evidence="11">
        <location>
            <begin position="115"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="(S)-2,3,4,5-tetrahydrodipicolinate binding" evidence="9">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO48894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL33035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="253" mass="27397" checksum="313AECB5313A7A39" modified="2016-09-07" version="1">MVKIIMHGCNGHMGQVISGLVEKDPDAEIVAGIDVADQGKNSYPVYTNMEECQVEADALIDFSSAKATDALLAYCEKRKLPVVLCTTGLSEEQLAKVEETSKNVAVLKSANMSLGINTLMKLLQDAAKVLATAGFDMEIVEKHHRLKLDAPSGTALALADSINEAMDNQYHYIYDRSQRREMRDDKEIGISAVRGGTIVGEHEVIFAGPDEVIEFKHTAYSKAVFGKGAVEAAKFLAGKPAGRYDMSDVISAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FS11</accession>
    <name>A0A174FS11_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cys_rich_VLP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201142.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53034">
        <property type="protein sequence ID" value="CUO53034"/>
        <property type="gene ID" value="ERS852478_03092"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBYW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025973">
        <property type="entry name" value="Cys_rich_VLP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14194">
        <property type="entry name" value="Cys_rich_VLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cys_rich_VLP" evidence="1">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO53034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="121" mass="14010" checksum="1B7B78D7A382F788" modified="2016-09-07" version="1">MTGSKRLTPPQSRKVNSLVKKECCNCERGHCILLDDGEECVCPQLISYSLLCKWFQIAVLPLDKLLYAELFKTEDKKRCTECGTFFVSKSNSVKYCPDCRKRIIRRQAAERMRKRRAAVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FTE1</accession>
    <name>A0A174FTE1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA primase</fullName>
            <ecNumber evidence="5">2.7.7.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dnaG_4</name>
        <name evidence="5" type="ORF">ERS852478_03108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201167.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53473">
        <property type="protein sequence ID" value="CUO53473"/>
        <property type="gene ID" value="ERS852478_03108"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZnF_CHCC" evidence="4">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO53473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="214" mass="24226" checksum="FF9A2D5E0E3A7ED2" modified="2016-09-07" version="1">MNVFEAVKQSVTTRQAAEHYGIRVNRNGMACCSFHNDKTPSMKLDKRFHCFGCGADGDVIDFVAALYGLGKKEAAAQLASDFGLAYEDWKPPGRARKPKPRQKSPEEQFREAKAHCFRVLADYLHLLRVWKTDYAPHSPEEAFHPRFVEALQKQAHVEYLLDVLLFGDTEEIASLITEHGKDVIQLEQRMAEIAAADAARTKKHHERHAAAPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FWS6</accession>
    <name>A0A174FWS6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6017 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53897">
        <property type="protein sequence ID" value="CUO53897"/>
        <property type="gene ID" value="ERS852478_03124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046059">
        <property type="entry name" value="DUF6017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19481">
        <property type="entry name" value="DUF6017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6017" evidence="2">
        <location>
            <begin position="157"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO53897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="322" mass="37031" checksum="21CC7C05AF521A8F" modified="2016-09-07" version="1">MAVFRVEKNKGYTVMSNHHLRNKELSLKAKGLLSQMLSLPEDWDYTLAGLSLINREKIDAIREAVRELENAGYIQRSRERDEKGRLRGTTYVIYEQPPKLDLPTLEKPTLDNPTLEKPMLEKPTLENPTQLNKELLKTNLPNKEKLNTDISSTHSIPFHSLNPSPLEDAAQPPERKRTEATDAYSVYEEIIKDNIEYDYLIQDRYLDRDRIEEILALILETVCTKRRTIRIAGDDHPAELVKAKFMKLNGEHIRFVLDCMQENTTKIRNIKQYMKAALFNAPSTIGSYYTSLVSHDMYGGRTIQSARSKGIPDYTCNEGESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FZA0</accession>
    <name>A0A174FZA0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_00685</name>
        <name evidence="1" type="ORF">ERS852478_03148</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO54747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000015">
        <property type="protein sequence ID" value="VUX62936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201202.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000098.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54747">
        <property type="protein sequence ID" value="CUO54747"/>
        <property type="gene ID" value="ERS852478_03148"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO54747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX62936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="61" mass="6734" checksum="8703CEEAC9A33BBF" modified="2016-09-07" version="1">MDYMTLKEASEKWGVTPRQINYLCASGRIPGAVKMAGVWLIPKTAEKPVDGRTKQGKVQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G4V4</accession>
    <name>A0A174G4V4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="5">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">trpA</name>
        <name evidence="7" type="ORF">ERS852478_03227</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381375.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIOY010000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57582">
        <property type="protein sequence ID" value="CUO57582"/>
        <property type="gene ID" value="ERS852478_03227"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO57582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="259" mass="28078" checksum="AC51627154CF57E9" modified="2016-09-07" version="1">MNKRITEAFEKGKAFIPFITCGDPSLEVTEQLVYAMEEAGADLIELGIPFSDPTAEGPVIQRANVRALSGGVTTDKVFDMVVKIRKNSSVPMVFMTYANVVFSYGTERFIKTAAEIGMDGLILPDVPFEEKEEFDIVCKKYGVDLISLIAPTSHERVAQIAKDAEGFVYCVSSLGVTGTRTNITTDIEAMVKLVKQAKDIPCAVGFGISTPEQAKKMAAQSDGAIVGSAIVKLCAQYGRDCVPYVKEYVKSMKDAVMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G8Q1</accession>
    <name>A0A174G8Q1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">phoR_10</name>
        <name evidence="11" type="ORF">ERS852478_03210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201236.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56875">
        <property type="protein sequence ID" value="CUO56875"/>
        <property type="gene ID" value="ERS852478_03210"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="217"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="298"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO56875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="514" mass="59209" checksum="91DA2CD3E9AAC617" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GFF7</accession>
    <name>A0A174GFF7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIN7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201288.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61282">
        <property type="protein sequence ID" value="CUO61282"/>
        <property type="gene ID" value="ERS852478_03336"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50333DZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041494">
        <property type="entry name" value="PIN7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18475">
        <property type="entry name" value="PIN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN7" evidence="2">
        <location>
            <begin position="9"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO61282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="254" mass="29249" checksum="938EFCA4E085014D" modified="2016-09-07" version="1">MKIIKTYYLIDYENVGSEGFKGCEKLRETDIIHLFYTDNSRKIDLDIINDHGESKLITHKVPTGNQSADMHLGSYLGYLIGKECTGQDEECKIVVISKDTGFDHIIEFWKAEKNVKISRNEKISGKQVQTRKQVKKQTGKEKDKQVAEQTDQKIEKQLNEQPEKQSAKQSENQNTKKPKQKIIDMKAGTKKLQQELVLVLDKAGMPKEVVNYVSTTVEKNAEDKNRKQQIYRSIISKYGQTKGLNIYNHIKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GH74</accession>
    <name>A0A174GH74_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase and inactivated derivatives</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO59815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070102140.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000031.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59815">
        <property type="protein sequence ID" value="CUO59815"/>
        <property type="gene ID" value="ERS852478_03297"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01797">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO59815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="136" mass="16099" checksum="A1F21E7396683F0B" modified="2016-09-07" version="1">MKENLIHYRTCVCNINYHMVWSVKYRRKILSAEVEAYLQKLVQEIAEDKGFTVHLFECGEGDHVHCFVSAPPKLSITAIVKYLKGISGRKLFERFPEIRNQLWKGELWNHSYYVEMVGSVSEENIRRYIEHQSKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GJ37</accession>
    <name>A0A174GJ37_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60990">
        <property type="protein sequence ID" value="CUO60990"/>
        <property type="gene ID" value="ERS852478_03333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO60990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="83" mass="9911" checksum="413D1655505EE03F" modified="2016-09-07" version="1">MTEIVDESRRSILRKEFYMDGLNCDPVSFDKECELTNAHFYKNEKREDIKSHHYIISYVPADVKTEKSSHSERTRHGFENENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GKL3</accession>
    <name>A0A174GKL3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tellurite resistance protein TehB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201295.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61439">
        <property type="protein sequence ID" value="CUO61439"/>
        <property type="gene ID" value="ERS852478_03342"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="44"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO61439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="198" mass="23109" checksum="496E3669C0721877" modified="2016-09-07" version="1">MADIDKTLKYYNENAQSFASGTVSVKFTEVQDKFLEKLNPDAYILDFGCGAGRDTKYFLSRGYQIDAIDGSEQLCWIASEYTGIKVRQMLFQELDEKEKYDGIWACASVLHLPKKQLREVLENMYASLKLEGWIYTSFKYGEFEGERNGRYFTDFTTDTFKEFIHDMHGLKIEEHWITGDVRPGRGEEKWLNLLLQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GMC3</accession>
    <name>A0A174GMC3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">BMC domain protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">BMC domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Carboxysome structural protein EutK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_01441</name>
        <name evidence="3" type="ORF">ERS852478_03367</name>
        <name evidence="5" type="ORF">GT712_18815</name>
        <name evidence="4" type="ORF">GT728_19035</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">BIOML-A1</strain>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO62059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000079">
        <property type="protein sequence ID" value="MZL35210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000064">
        <property type="protein sequence ID" value="MZS91033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000033">
        <property type="protein sequence ID" value="VUX64587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703969.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000079.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A174GMC3"/>
    <dbReference type="EnsemblBacteria" id="CUO62059">
        <property type="protein sequence ID" value="CUO62059"/>
        <property type="gene ID" value="ERS852478_03367"/>
    </dbReference>
    <dbReference type="GeneID" id="66494068"/>
    <dbReference type="eggNOG" id="COG4577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031469">
        <property type="term" value="C:bacterial microcompartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000249">
        <property type="entry name" value="BMC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037233">
        <property type="entry name" value="CcmK-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044872">
        <property type="entry name" value="CcmK/CsoS1_BMC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00936">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00877">
        <property type="entry name" value="BMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143414">
        <property type="entry name" value="SSF143414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51930">
        <property type="entry name" value="BMC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1283">Bacterial microcompartment</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BMC" evidence="2">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO62059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL35210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS91033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX64587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="95" mass="10064" checksum="1A353056863C6388" modified="2016-09-07" version="1">MSYGALGLVEVVGSCNAVVVLDQMLKTSDVEFRTWHTKCGGHATIFLSGDIAAVKAAVDAVKGNPPCEIIAAAVISAPSEETSRLVKEEEEKHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GMI3</accession>
    <name>A0A174GMI3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201307.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61655">
        <property type="protein sequence ID" value="CUO61655"/>
        <property type="gene ID" value="ERS852478_03351"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO61655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="121" mass="14353" checksum="57F3F2E80DD11783" modified="2016-09-07" version="1">MISFYKSIVDQDRASIVICNLKHEIIYMNPAAVNSYAKRGGDKLIGRSLLDCHNQESRDKIQKVVDWFATDESHNLVYTFHNEKQNKDVYMVALREEGRLIGYYEKHEYRNAETMKQYDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GS33</accession>
    <name>A0A174GS33_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate kinase</fullName>
            <shortName evidence="2">SK</shortName>
            <ecNumber evidence="2">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aroK_3</name>
        <name evidence="2" type="synonym">aroK</name>
        <name evidence="4" type="ORF">ERS852478_03400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201374.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63245">
        <property type="protein sequence ID" value="CUO63245"/>
        <property type="gene ID" value="ERS852478_03400"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="100"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO63245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="262" mass="30368" checksum="6A9A99A5D0B10C12" modified="2016-09-07" version="1">MSQLEILRESLGQCDEIILDALIMRNRIVEDIMAYKEANGLQILQPEQEAKQKEWLEKRMEGRRHKDEVSDVFECIRTNSKRIQARKLFNYNIVLIGFMGTGKSTISDFLKNVFAMDVAEMDQIIAQRQGMSISDIFETYGEQYFRNLETNLLIEMQSRSNVVISCGGGTPMRECNVVEMKKNGRVVLLTAEPETILDRVKDNHDRPLIENNKTVPFITELMEKRRAKYEAAADIIIETDGKNELEICEELVHRLRTMDEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GTM6</accession>
    <name>A0A174GTM6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pantothenate synthetase</fullName>
            <shortName evidence="5">PS</shortName>
            <ecNumber evidence="5">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">panC</name>
        <name evidence="9" type="ORF">BWLFYP14_02266</name>
        <name evidence="6" type="ORF">ERS852478_03432</name>
        <name evidence="8" type="ORF">GT712_16280</name>
        <name evidence="7" type="ORF">GT728_10865</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">BIOML-A1</strain>
            <strain evidence="8 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000024">
        <property type="protein sequence ID" value="MZL33686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000042">
        <property type="protein sequence ID" value="MZS90575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704364.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64179">
        <property type="protein sequence ID" value="CUO64179"/>
        <property type="gene ID" value="ERS852478_03432"/>
    </dbReference>
    <dbReference type="GeneID" id="66495125"/>
    <dbReference type="eggNOG" id="COG0414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="183"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO64179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL33686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS90575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX65901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="279" mass="31304" checksum="7762B75B1EFEC09D" modified="2016-09-07" version="1">MQVTKTVEETRKQIKAWKKEGKTIGLVPTMGFLHEGHASLIKKCREQNDIVVVSDFVNPTQFGPTEDLEAYPRDFERDSKLCESLGTDLIFCPEPSEMYHDPHAFVSIDTLSETLCGKTRPIHFKGVCTVVTKLFHIVAPDRAYFGQKDAQQLAIIRKMVQDLNFDIEIVGCPIVREEDGLAKSSRNTYLSDEERKAALCLSRSVKLGQEIIHAGISAEELLGKMRAVIEAEPLAKIDYVSMVDALTMQPVEKADHNVLVAMAVYIGKTRLIDNFSYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GWI0</accession>
    <name>A0A174GWI0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201416.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66944">
        <property type="protein sequence ID" value="CUO66944"/>
        <property type="gene ID" value="ERS852478_03522"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO66944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="104" mass="12026" checksum="79AC5B43FC830B16" modified="2016-09-07" version="1">MVLDIFPGTHFSRLKLLLGTNRYFNNAPLSKKITYKGSNYVVKIGKRSIKIIASNNFSENDINKIKKYIETMFQNRSILIDSTDELHWINDIPNVSVHTLNNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H2A1</accession>
    <name>A0A174H2A1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO68973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015542934.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68973">
        <property type="protein sequence ID" value="CUO68973"/>
        <property type="gene ID" value="ERS852478_03585"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025699">
        <property type="entry name" value="ABC2_memb-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13346">
        <property type="entry name" value="ABC2_membrane_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO68973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="216" mass="23738" checksum="E82214200F4D23B1" modified="2016-09-07" version="1">MSNILKSTKLDIALVKPYFKTICFTLLLPIVFAAINRSLLTGVSFAMCFIAMTTGYTFSITEKNSMDRLFGILPVRKSELVIGRYVFVLAMGLLSLIISLIAQPLVLKVLGETVGVFDIVTAAIAGVFLFALYTVFQIPGYYKYGSIKGRVFMYIPVAGFLVTLLLLSKMPAIGNSIISVVESSPILLVFLAVFAIVVMYAVSIFLSIRVMKNKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H6B5</accession>
    <name>A0A174H6B5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-hydantoinase</fullName>
            <ecNumber evidence="5">3.5.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_03634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201473.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70463">
        <property type="protein sequence ID" value="CUO70463"/>
        <property type="gene ID" value="ERS852478_03634"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="4">
        <location>
            <begin position="50"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO70463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="457" mass="50681" checksum="16AF382B0F1DD9E4" modified="2016-09-07" version="1">MKTLLKNGTVVSGDMSVREDVLIDGEKIVKVGRNLEAEDAQVVDVNGKLLFPGFIDGHTHFDLEVAGTVTADDFETGTRAAIAGGTTLVIDYASQDKGGHTLKEGLEKWHKKADGKCSCDYSFHMSVVEWNEETEREIQDMINEGITSFKLYMTYPAMIVDDGDLYKIIKKLNEYGCFAGVHCENAGAIDALIAEAKKEGRLGPENHPLVRPDIMEAEAVHRLLVIADAADAPVMVVHLTNRKAFEEVMRARMNGQKVYAETCPQYLLLDDSVYSKPDFEGAKYVCAPPIRKKADQDCLWKALANDQIQTVATDQCSFTMEQKALGKDDFTKIPGGLPGVQTRGTLLYTYGVRTGRITQEQMCRLLSENAAKLYGVYPNKGVIREGSDADIVVFDPEKENVISAKTHLYHTDNNPYEGFKLHGDIDSVYLRGVHVVQDGKVILEKTGKYIKRGKNQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HBD3</accession>
    <name>A0A174HBD3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">Int-Tn_9</name>
        <name evidence="4" type="ORF">ERS852478_03697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO72154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72154">
        <property type="protein sequence ID" value="CUO72154"/>
        <property type="gene ID" value="ERS852478_03697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO72154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="158" mass="18108" checksum="727C7E8FBFE4EDC0" modified="2016-09-07" version="1">MQNKILNIDHQLLKDSEIGYYIETPKTKNGKRELPLTERAYQAIQRILKNRGKAQPLIVGGYSNFLFLNREGLPKVAGNYEGMVRGLIKKYNKYHTDKLPNITPHSFRHTYCTNMANRGMNPNTLQYLMGHANITMTLGYYAHGTFQSAKAELERLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HCN3</accession>
    <name>A0A174HCN3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxalate decarboxylase oxdD</fullName>
            <ecNumber evidence="2">4.1.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">oxdD</name>
        <name evidence="2" type="ORF">ERS852478_03646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381443.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70779">
        <property type="protein sequence ID" value="CUO70779"/>
        <property type="gene ID" value="ERS852478_03646"/>
    </dbReference>
    <dbReference type="GeneID" id="66494343"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046564">
        <property type="term" value="F:oxalate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="37"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO70779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="108" mass="11942" checksum="FBF1CF1186BFD46C" modified="2016-09-07" version="1">MRIRREEHMAGGNGHVIIKEILDAEQLNGKCGLYAQVTLEPGCSLGYHEHHGESETYYILQGQGEYNDNGTYRPVKAGDITFTPDNHGHALANTGNTDLVFMALIIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HDG1</accession>
    <name>A0A174HDG1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fluoroquinolones export ATP-binding protein Rv2688c/MT2762</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_03666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201480.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71376">
        <property type="protein sequence ID" value="CUO71376"/>
        <property type="gene ID" value="ERS852478_03666"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022501">
        <property type="entry name" value="ABC_Gallidermin_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03740">
        <property type="entry name" value="galliderm_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="25"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO71376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="254" mass="27927" checksum="8A6D7FAF16521105" modified="2016-09-07" version="1">MKSSKLPGMLSVKSKKGLDYMDMILKTTDLCKNFKGQMAVNNVSLNIRRNSVYGLLGPNGAGKSTILKMLTGILRPTSGSIEFDGHPWKRNDLEHIGALIEMPPLYENLTAYENLKVRTTLLGLDDARINEVLQIVQLTNTGKKRAGQFSLGMKQRLGIAIALLNSPQLLILDEPTNGLDPLGIEELRELIRSFPCKGITVILSSHILSEVQQIADHVGIIAGGVLGYEGELRAGEDLEQLFMDVVRRNGKEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HEV7</accession>
    <name>A0A174HEV7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03682</name>
        <name evidence="3" type="ORF">ERS852523_03746</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO71917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000063">
        <property type="protein sequence ID" value="CUQ04761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008393100.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71917">
        <property type="protein sequence ID" value="CUO71917"/>
        <property type="gene ID" value="ERS852478_03682"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ04761">
        <property type="protein sequence ID" value="CUQ04761"/>
        <property type="gene ID" value="ERS852523_03746"/>
    </dbReference>
    <dbReference type="GeneID" id="15230415"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ04761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="137" mass="15180" checksum="5580A912FB8549AD" modified="2016-09-07" version="1">MKHKIQKVELFVGVIVLLGGLLTYGLGVHQLLPVPRPDLVVYGTTLIGIILILMGCDIFSKPTKEMQILENDERNIAITNASLANAYKVTLTLLVLVLFALIFMGYMSKVVFFSIVGVIAIGQITWVITARYLDKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HGP7</accession>
    <name>A0A174HGP7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="2">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">fcl</name>
        <name evidence="4" type="ORF">ERS852478_03709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18885"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.271"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000044">
        <property type="protein sequence ID" value="CUO72557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201499.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPB010000052.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72557">
        <property type="protein sequence ID" value="CUO72557"/>
        <property type="gene ID" value="ERS852478_03709"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="165"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO72557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="314" mass="35447" checksum="DEC7135A3EF27C3C" modified="2016-09-07" version="1">MMEKNAKIYVAGHRGMVGSAIVRELQRQGYTNIVTRTHKELDLTRQDAVEKFFATEKPEYVFLAAAKVGGIVANQNALADFMYDNMILEMNVIHSAWKNGCRKLEFLGSSCIYPRMAPQPMKESCLLTSELEKTNEAYALAKISGLKYCEFLNRQYGTDYISVMPTNLYGPNDNYHPTHSHVLPALIRRFHEAKESGAESVTCWGDGSPLREFLYVDDLANLCVFLMNNYSGNETVNAGTGKELTIKELTELVAKVVGYDGEIKWDPDKPNGTPRKLLDVSKATNLGWTYKTELEDGIRLAYEDFLNNPMRAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HIT4</accession>
    <name>A0A174HIT4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000045">
        <property type="protein sequence ID" value="CUO73247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73247">
        <property type="protein sequence ID" value="CUO73247"/>
        <property type="gene ID" value="ERS852478_03734"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Recombinase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO73247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="252" mass="29753" checksum="6DA770AC5D8D7BE4" modified="2016-09-07" version="1">MHTGHKAVLNDETEWVRLENHHTAIIDRELFEKANEMHPKKKRSVAESRTNFTLERRKKQPALLICANCGHSLLKETEHLLKCSDARTNGDPVCRSLVIRREPMEENILGLVRQYAASMLKKGKKVSSKRQCEYKEINTTELQKQSRQLTSEKMKLYDDYKDGRIDRDSYKQRAEKISVQLDEIKRKIEDAKNSKKLLEQNELSDKIKLKDFLGIQKFDTEKLREVIKVIRVHSQDEIEIEWNFDDIFSEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HMY3</accession>
    <name>A0A174HMY3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-galactonate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dgoD</name>
        <name evidence="3" type="ORF">ERS852478_03808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.6" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000052">
        <property type="protein sequence ID" value="CUO75571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060736.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000052.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75571">
        <property type="protein sequence ID" value="CUO75571"/>
        <property type="gene ID" value="ERS852478_03808"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:cellular amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03325">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="Mandelate_racemase_DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="PTHR48080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00003">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="2">
        <location>
            <begin position="125"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO75571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="382" mass="42286" checksum="685D828F16FF41A5" modified="2016-09-07" version="1">MKIVEVNAYHVRPRWGFVEIITDEGITGWGEAVLEGHCDAVLACVQEYRSYLIGQDPFRIEDISATIFRAGFYRGGGVLMSALSGIDQALWDIKGKAFGAPAYELMGGKCRDKIKVYSWIGGDRPSDVGTAAKERQDAGFKAIKMNATEELQMIDSYDKIDAVLERVAAIRESCGKYFGIAIDFHGRVHKPMAKILAKKLEEFDPMFIEEPVLCENMEVFKEIAVACNIPIATGERLFTKYDFKRLLQAGGVDIIQPDLSHAGGLTEVKKIASMAEAYDVALAPHCPLGPIALAACLNVDATCYNAVIQEQSIGIHYNVGKSVLDYALNKQDFQFVDGFCAMPTKPGLGIEVNKELVLEENLTKHQWKNPIWRHVDGSVAEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KAQ2</accession>
    <name>A0A174KAQ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding transcriptional regulator AraC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Transposon Tn10 TetD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tetD</name>
        <name evidence="6" type="ORF">BWLFYP14_03026</name>
        <name evidence="2" type="ORF">ERS852478_01208</name>
        <name evidence="3" type="ORF">ERS852523_00527</name>
        <name evidence="5" type="ORF">GT712_03800</name>
        <name evidence="4" type="ORF">GT728_00155</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN84061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP09104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704032.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000061_gene491"/>
    <dbReference type="EnsemblBacteria" id="CUN84061">
        <property type="protein sequence ID" value="CUN84061"/>
        <property type="gene ID" value="ERS852478_01208"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP09104">
        <property type="protein sequence ID" value="CUP09104"/>
        <property type="gene ID" value="ERS852523_00527"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="142"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN84061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP09104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL31644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="265" mass="31354" checksum="00CD86B87A843CFD" modified="2016-09-07" version="1">MSYQNEWLLFEAEDEFDEIKHREPTEELLFYRAVASGDIKTVKKNCERQRFTECDGVGVLSKNAVTNMKYHFVITTAMITRLCKQNGMEMEQAFRLSDFYIQKLDGIHTVEEVQSLHDEMVMDYTEKMRRYFRDNTYSKHINASKEYIYSHIKERITIEDLADSLGVSASYLSRLFKKETGISVSAYIRRQKIEMAKNLLQYSDYPIIEIANRLSFSSQSHFIQQFREVTGMTPGKYRDEHYMIHWDIEKELCVASESELKKEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KED0</accession>
    <name>A0A174KED0_9FIRM</name>
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        <submittedName>
            <fullName evidence="4">4'-phosphopantetheinyl transferase sfp</fullName>
            <ecNumber evidence="4">2.7.8.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="5">4'-phosphopantetheinyl transferase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sfp_1</name>
        <name evidence="6" type="synonym">sfp_2</name>
        <name evidence="6" type="ORF">BWLFYP14_03084</name>
        <name evidence="3" type="ORF">ERS852478_01150</name>
        <name evidence="4" type="ORF">ERS852523_00471</name>
        <name evidence="5" type="ORF">GT712_03515</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
            <strain evidence="4 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.8.-" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP07589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704112.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2152"/>
    <dbReference type="EnsemblBacteria" id="CUN81929">
        <property type="protein sequence ID" value="CUN81929"/>
        <property type="gene ID" value="ERS852478_01150"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07589">
        <property type="protein sequence ID" value="CUP07589"/>
        <property type="gene ID" value="ERS852523_00471"/>
    </dbReference>
    <dbReference type="GeneID" id="66493986"/>
    <dbReference type="eggNOG" id="COG2091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
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        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="2">
        <location>
            <begin position="82"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN81929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP07589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="183" mass="21558" checksum="BDF3D61849006C90" modified="2016-09-07" version="1">MNKGIIYCTKIREEYEGAHMEHMIAEKLLEIALKKEYGINLYNEPRAEGEHGKPFLSYRPSLHYNISHSGKYVVCILADQEVGIDVQIHCRANYERMLRRMVPREQYLEILSDINVEKKFFEQWVLREAYIKWTGEGLSRDMRTISMDEGSHMLLDMEDGYSGAVWAMNPMEINWKYEDIILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KG86</accession>
    <name>A0A174KG86_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease Y</fullName>
            <shortName evidence="5">RNase Y</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 10" type="primary">rny</name>
        <name evidence="13" type="ORF">BWLFYP14_03058</name>
        <name evidence="9" type="ORF">ERS852478_01176</name>
        <name evidence="10" type="ORF">ERS852523_00497</name>
        <name evidence="12" type="ORF">GT712_03645</name>
        <name evidence="11" type="ORF">GT728_00310</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Y family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP08269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZS88206.1"/>
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            <end position="26"/>
        </location>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
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            <taxon>Clostridia</taxon>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
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                <person name="Alm E.J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
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                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="ERS852478_00056"/>
    </dbReference>
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        <property type="gene ID" value="ERS852523_00711"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP15422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="EMBL" id="MZL32219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="81" mass="8788" checksum="4FEF5AA4DF885C75" modified="2016-09-07" version="1">MESRIAVISIIVENSDSVECLNRILHEYGIYIIGRMGIPYRQRGISIISVAIDAPLDIINALTGKIGRLAGVSAKTVYSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KXR2</accession>
    <name>A0A174KXR2_9FIRM</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02567</name>
        <name evidence="2" type="ORF">ERS852478_00066</name>
        <name evidence="3" type="ORF">ERS852523_00701</name>
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    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
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            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
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                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000005">
        <property type="protein sequence ID" value="MZL32209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703066.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1429"/>
    <dbReference type="EnsemblBacteria" id="CUN42727">
        <property type="protein sequence ID" value="CUN42727"/>
        <property type="gene ID" value="ERS852478_00066"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15146">
        <property type="protein sequence ID" value="CUP15146"/>
        <property type="gene ID" value="ERS852523_00701"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50330JY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046092">
        <property type="entry name" value="DUF6110"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19605">
        <property type="entry name" value="DUF6110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN42727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP15146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="111" mass="11976" checksum="184FF68FA18A39C4" modified="2016-09-07" version="1">MIKFDGKKTGIFAAGVAFGTAGIKILTSKDAKKLYTNCTAAVLRAKACVMKTASAIQENAEDIYAEAQQINEDRAAAEEVVEDTADEAAEETEETTDFKEETEETEEGSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LCC5</accession>
    <name>A0A174LCC5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">yycF_1</name>
        <name evidence="11" type="synonym">yycF_3</name>
        <name evidence="14" type="ORF">BWLFYP14_01620</name>
        <name evidence="11" type="ORF">ERS852478_01278</name>
        <name evidence="12" type="ORF">ERS852523_00870</name>
        <name evidence="13" type="ORF">GT728_08330</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">2789STDY5834863</strain>
            <strain evidence="12 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="13 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 18">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000007">
        <property type="protein sequence ID" value="CUP20187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000015">
        <property type="protein sequence ID" value="MZL33204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705651.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000015.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000052_gene886"/>
    <dbReference type="EnsemblBacteria" id="CUN87587">
        <property type="protein sequence ID" value="CUN87587"/>
        <property type="gene ID" value="ERS852478_01278"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20187">
        <property type="protein sequence ID" value="CUP20187"/>
        <property type="gene ID" value="ERS852523_00870"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="10">
        <location>
            <begin position="133"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="133"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN87587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP20187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL33204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX64765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="233" mass="26789" checksum="A15BC13781EBE86A" modified="2016-09-07" version="1">MVSKQKILIVDDDNNIAELIALYLTKECFETKIVNDGEEALREFASFRPDLIILDLMLPGIDGYQVCREIRHTSDVPIIMLSAKGETFDKVLGLELGADDYMIKPFDSKELVARVRAVLRRFQVKQPSPSSSEKCVTYPDLTVNLTNYAVTYMGRQVDMPPKELELLYFLAASPNQVFTREQLLDHIWGYEYIGDTRTVDVHIKRLREKIKDNPHWSIATVWGIGYKFEVKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MCS6</accession>
    <name>A0A174MCS6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Predicted methyltransferase (Contains TPR repeat)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_01573</name>
        <name evidence="6" type="ORF">ERS852523_01312</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
            <strain evidence="6 8">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP34162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055150455.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000057_gene2523"/>
    <dbReference type="EnsemblBacteria" id="CUN99694">
        <property type="protein sequence ID" value="CUN99694"/>
        <property type="gene ID" value="ERS852478_01573"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP34162">
        <property type="protein sequence ID" value="CUP34162"/>
        <property type="gene ID" value="ERS852523_01312"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="373"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN99694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP34162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="445" mass="49227" checksum="21389B0FFD9E1DD5" modified="2016-09-07" version="1">MNCMNCGAFLVDKDLDYCPKCGCNVLIQKKVDYLSRQYYNRGLEKASVRDLSGAIDCLKQSLIYNKHNIQARNLLGLVYFETGEVVAALSEWVISKNLQPSRNLASEYINKLQANSNKLEAINETIRKYNDALNLCREGHEDMAAIRLKKILIQNPKLIKGYHLLALVQMKEGEYNKARKTLRKAARIDKTNTTTLRFLREIDEQTGVSTRLERQNKRNRKAVDSSENDMAIQIPQYKEKGRIPLFFTLVAGFCAGLLAFYLLAVPAIRQGIYREANQQIMKYSDAVSSQGAELTKAQSQAQESGDTVEAASKQIEEEKKKSSSYEALIEAYSALQQQNTDEAALKIQNVYADLLPADLKGIYNTICNTTGTTGIEGTTDAKVTDGTGSADSAEGDASSDSAEDGSYDDGSYDSGEYDDGSYDNSDGDSADDGSYDTGDYDDSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MF72</accession>
    <name>A0A174MF72_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Catabolite repression HPr</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">HPr family phosphocarrier protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">HPr-like protein Crh</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">crh_1</name>
        <name evidence="2" type="synonym">crh_2</name>
        <name evidence="6" type="ORF">BWLFYP14_00252</name>
        <name evidence="2" type="ORF">ERS852478_01654</name>
        <name evidence="3" type="ORF">ERS852523_01298</name>
        <name evidence="5" type="ORF">GT712_09005</name>
        <name evidence="4" type="ORF">GT728_04675</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707243.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2987"/>
    <dbReference type="EnsemblBacteria" id="CUO02485">
        <property type="protein sequence ID" value="CUO02485"/>
        <property type="gene ID" value="ERS852478_01654"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33771">
        <property type="protein sequence ID" value="CUP33771"/>
        <property type="gene ID" value="ERS852523_01298"/>
    </dbReference>
    <dbReference type="GeneID" id="66496117"/>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO02485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP33771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX67411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="84" mass="9057" checksum="1CC6D79441BC222C" modified="2016-09-07" version="1">MIKKPITINLSTGLEARPVAQLVQVASQFNSEIYVEIGKKRVNAKSIMGMMTLGLDAGEEITLSANGEDEEAAMAGIEQYLSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MFE5</accession>
    <name>A0A174MFE5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Adenylate kinase</fullName>
            <shortName evidence="8">AK</shortName>
            <ecNumber evidence="8 10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">adk</name>
        <name evidence="16" type="ORF">BWLFYP14_00276</name>
        <name evidence="12" type="ORF">ERS852478_01678</name>
        <name evidence="13" type="ORF">ERS852523_01274</name>
        <name evidence="15" type="ORF">GT712_08885</name>
        <name evidence="14" type="ORF">GT728_04795</name>
    </gene>
    <organism evidence="13 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 17">2789STDY5834863</strain>
            <strain evidence="13 18">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="14 20 21" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 21">BIOML-A1</strain>
            <strain evidence="15 20">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="16 19" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="8 10"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707277.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2963"/>
    <dbReference type="EnsemblBacteria" id="CUO03340">
        <property type="protein sequence ID" value="CUO03340"/>
        <property type="gene ID" value="ERS852478_01678"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33028">
        <property type="protein sequence ID" value="CUP33028"/>
        <property type="gene ID" value="ERS852523_01274"/>
    </dbReference>
    <dbReference type="GeneID" id="66496141"/>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
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            <dbReference type="Pfam" id="PF05191"/>
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            <dbReference type="EMBL" id="VUX67435.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
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        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
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            <dbReference type="Proteomes" id="UP000366766"/>
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        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
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    </evidence>
    <sequence length="214" mass="23376" checksum="73850BB2678185A6" modified="2016-09-07" version="1">MKIIMLGAPGAGKGTQAKKIAAKYQIPHISTGDIFRANIKNGTELGKKAKTYMDQGLLVPDELTCDLVVDRIQQPDAANGYVLDGFPRTIPQAECLTEALNKLGSKVDYAIDVDVPDSNIVNRMSGRRACLKCGATYHVVHAAPKVEGVCDTCGEKLVLRDDDQPETVQKRLNVYHEQTQPLIDYYTKEGILKSVDGTKDLEEVFADIVAILGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NHV8</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 8">2789STDY5834863</strain>
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    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
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                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174P6Q4</accession>
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            <taxon>Clostridia</taxon>
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            <taxon>Blautia</taxon>
        </lineage>
    </organism>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 11">2789STDY5834863</strain>
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    </reference>
    <reference evidence="9 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
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                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000019">
        <property type="protein sequence ID" value="CUP55201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381476.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1137"/>
    <dbReference type="EnsemblBacteria" id="CUO30309">
        <property type="protein sequence ID" value="CUO30309"/>
        <property type="gene ID" value="ERS852478_02410"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP55201">
        <property type="protein sequence ID" value="CUP55201"/>
        <property type="gene ID" value="ERS852523_01989"/>
    </dbReference>
    <dbReference type="GeneID" id="66494296"/>
    <dbReference type="eggNOG" id="COG1648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="PTHR35330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO30309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP55201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS88354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX66574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="165" mass="18893" checksum="B28B0F2ABFAD106A" modified="2016-09-07" version="1">MKNKPYFPMFIDLSDKNIVVVGGGNIATRRVKTLLSFTRNIRVIAPKVTMEMMELGKAGYVELITRPVKRTDFAMAYMVIAATNDRKLNDEIHRICRQEGVYVNVASDREQCDFYFPGIYMEEGLVVGITASGLDHKKARRIREEIQNALERVAQEDDNEEENDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174PRW2</accession>
    <name>A0A174PRW2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rd</name>
        <name evidence="13" type="ORF">BWLFYP14_02344</name>
        <name evidence="9" type="ORF">ERS852478_03474</name>
        <name evidence="10" type="ORF">ERS852523_02239</name>
        <name evidence="12" type="ORF">GT712_16555</name>
        <name evidence="11" type="ORF">GT728_16080</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="6 7">Binds 1 Fe(3+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the rubredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000022">
        <property type="protein sequence ID" value="CUP62366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000048">
        <property type="protein sequence ID" value="MZL34670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993356.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65476">
        <property type="protein sequence ID" value="CUO65476"/>
        <property type="gene ID" value="ERS852478_03474"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP62366">
        <property type="protein sequence ID" value="CUP62366"/>
        <property type="gene ID" value="ERS852523_02239"/>
    </dbReference>
    <dbReference type="GeneID" id="66493932"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024922">
        <property type="entry name" value="Rubredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000071">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000071-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO65476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP62366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL34670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS90626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX65974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="54" mass="5926" checksum="25B13CDAB7B8EC3E" modified="2016-09-07" version="1">MIKYECEPCGYIYDPAVGDPDAGIDPETAFEDIPDDWTCPICGLGKDVFVPVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174Q6S6</accession>
    <name>A0A174Q6S6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02264</name>
        <name evidence="2" type="ORF">ERS852523_02415</name>
        <name evidence="3" type="ORF">GT728_09300</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000025">
        <property type="protein sequence ID" value="CUP67591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000018">
        <property type="protein sequence ID" value="MZL33388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993367.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000042_gene3016"/>
    <dbReference type="EnsemblBacteria" id="CUO25072">
        <property type="protein sequence ID" value="CUO25072"/>
        <property type="gene ID" value="ERS852478_02264"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP67591">
        <property type="protein sequence ID" value="CUP67591"/>
        <property type="gene ID" value="ERS852523_02415"/>
    </dbReference>
    <dbReference type="GeneID" id="66493779"/>
    <dbReference type="eggNOG" id="ENOG5032RA4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043779">
        <property type="entry name" value="DUF5721"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18988">
        <property type="entry name" value="DUF5721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO25072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP67591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="166" mass="19416" checksum="1266168D4CBF159C" modified="2016-09-07" version="1">MLALKITDVKDFMNKLLIGEVFDRFSLVEASVTTFNTFTINGKLHYDFFDTDTKAAFEENSTEYSLWHDVKPYCFSIIRGRRTPLNFRIVFELSHDQTQSLLKNEQHIADIPVQSFYLNIRYKNQSLLCTTGVSYTSFSPDKRLEHLWDDSMTVFLSSHHIPCEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174Q7X7</accession>
    <name>A0A174Q7X7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartokinase</fullName>
            <ecNumber evidence="12">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">thrA</name>
        <name evidence="15" type="ORF">ERS852478_02284</name>
        <name evidence="16" type="ORF">ERS852523_02395</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 17">2789STDY5834863</strain>
            <strain evidence="16 18">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="12"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000025">
        <property type="protein sequence ID" value="CUP67078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705535.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000071_gene3934"/>
    <dbReference type="EnsemblBacteria" id="CUO25709">
        <property type="protein sequence ID" value="CUO25709"/>
        <property type="gene ID" value="ERS852478_02284"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP67078">
        <property type="protein sequence ID" value="CUP67078"/>
        <property type="gene ID" value="ERS852523_02395"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="7 12 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="376"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="6"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUO25709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUP67078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="439" mass="48644" checksum="89CE76310DBD0081" modified="2016-09-07" version="1">MKKIVKFGGSSLANAEQFQKVGEIIRSDESRRYVVPSAPGKRFDGDTKVTDLLYKCYNTAVEGEDFIPILQEIKGRYYEIIRGLNLDLSLEDEFAQIEADFKAQAGTDYAASRGEFLNGKVMAAYLGYEFVDAADVIRFDKNGNLDAEKTDRLLSKKLAKCEHAVIPGFYGAGEDGKVKTFSRGGSDVTGSLVAKAIKADLYENWTDVSGFLVTDPRIVKNPEVIESITYRELRELSYMGATVLHEDAIFPVRKEGIPINIKNTNRPEDKGTFIVESTCKKPKFTITGIAGKKGFCSINIEKSMMNSEVGFGRKVLQVFEDQGISFEHVPSGIDTMTVYVHQDEFEEKEQQVIAGIHRAVQPDFVEMESDLALIAVVGRGMKSTRGTAGRIFSALAHANVNVKMIDQGSSELNIIIGVENRDFETAVKAIYDIFVITQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SW74</accession>
    <name>A0A174SW74_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease Z</fullName>
            <shortName evidence="8">RNase Z</shortName>
            <ecNumber evidence="8">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">rnz</name>
        <name evidence="14" type="ORF">BWLFYP14_02879</name>
        <name evidence="10" type="ORF">ERS852478_02832</name>
        <name evidence="11" type="ORF">ERS852523_03588</name>
        <name evidence="13" type="ORF">GT712_17630</name>
        <name evidence="12" type="ORF">GT728_14510</name>
    </gene>
    <organism evidence="11 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">2789STDY5834863</strain>
            <strain evidence="11 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 19">BIOML-A1</strain>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000056">
        <property type="protein sequence ID" value="CUQ00571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000038">
        <property type="protein sequence ID" value="MZL34379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000052">
        <property type="protein sequence ID" value="MZS90829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000064">
        <property type="protein sequence ID" value="VUX66502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705877.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000038.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000066_gene3220"/>
    <dbReference type="EnsemblBacteria" id="CUO44478">
        <property type="protein sequence ID" value="CUO44478"/>
        <property type="gene ID" value="ERS852478_02832"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ00571">
        <property type="protein sequence ID" value="CUQ00571"/>
        <property type="gene ID" value="ERS852523_03588"/>
    </dbReference>
    <dbReference type="GeneID" id="66494777"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
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    </dbReference>
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        <property type="entry name" value="SSF56281"/>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="9">
        <location>
            <begin position="32"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
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        <location>
            <position position="63"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </source>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="CUO44478.1"/>
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        <source>
            <dbReference type="EMBL" id="CUQ00571.1"/>
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        <source>
            <dbReference type="EMBL" id="MZL34379.1"/>
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            <dbReference type="EMBL" id="MZS90829.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="302" mass="34192" checksum="6DCEE4136138F318" modified="2016-09-07" version="1">MLDVCLVGTGGMMPLPRRWLTALMTRYNGSSLLIDCGEGTQVAIKEKGWSFKPIDVICFTHYHGDHISGLPGLLLTMGNADRTEPLTLVGPKGLERVVNALRVIAPELPFEIKFIEITQPEQVIELNGYRITAFKVNHNVLCYGYTLEILRQGKFSAERAKEQDIPLKYWNPLQKGQTIEADGITYTPEMVLGPARKGIRLTYTTDTRPTESILRNAKESDLFICEGMYGEDDKADKARGYKHMTFREAAVLARDARVKEMWLTHYSPSLVRPDEFMDKVREIFPNAYPGKDGKSLELNFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X3E2</accession>
    <name>A0A173X3E2_9FIRM</name>
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        </submittedName>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
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                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUN45850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="129" mass="14910" checksum="A7181FAFE86BCDFF" modified="2016-09-07" version="1">MEDAELRNILFSIQGSIAGFQNDMSDVKNDIADMRTDIANMKTDITNMKADITNMKTDITNMKSDIVQLKGSVKTIELKLENEIDRKISALFDSRMDELRYRKENKETREKVFELDMRVDNLEKAIMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X3G5</accession>
    <name>A0A173X3G5_9FIRM</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BWLFYP14_02682</name>
        <name evidence="1" type="ORF">ERS852478_00186</name>
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        <name type="scientific">Blautia wexlerae</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
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    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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    </dbReference>
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            <dbReference type="EMBL" id="CUN45880.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="VUX66309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="413" mass="47304" checksum="B87700035131DF9C" modified="2016-09-07" version="1">MAVFHAFRALRPTPEKAADVAALPYDVVNREEAKSIGDENPLSFLHIDRPEMDLEPETDLYDDRVYEKAKENLDNMEEKGILVQDQKACYYIYELVRKGKTQTGIVGCSSIDDYMNGVVKKHELTREDKEQDRIHHVDSCNANTGPIFLACRYPDSLLTLMNNWKDHHEAAYDFTEEDQITHRVWVIDEDEVISEINKEFAGIDSLYIADGHHRAASAVKVGLKRREQNPGYTGEEEFNYFLSVVFPYDQLCILPYNRIVKDLNGLTVKAFLGALKFNFELMLMPGFPCKPVEKHCMGMYVDGQWYHLKAWPDIYEKKDVVGQLDVSILQEKVLRPVLGIEDPRTDQRISFVGGSHKAAELAEIADRTGGVAFVMYPTSMEDLMKIADENKLMPPKSTWFEPKLRSGLFIHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XG44</accession>
    <name>A0A173XG44_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribose transport system permease protein rbsC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rbsC_1</name>
        <name evidence="7" type="ORF">ERS852478_00298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
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            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199556.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50270">
        <property type="protein sequence ID" value="CUN50270"/>
        <property type="gene ID" value="ERS852478_00298"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN50270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="330" mass="34732" checksum="D5723AB99C542127" modified="2016-09-07" version="1">MEKKSIMKKITGSREALLAVILILLCLVVTAISPSFLTPKSIMELLKNNAVTLVMSLGMLCVMLVGGIDISIMSTLALSGMSVGMLLKYGHISNTFLAFVIAIAIGAACGAVVGLVISRASVPPIIATMGFMYVFRAMGYLVSHGGEWAGAAALGNFKNFATSKFLGLNCVIWIIIFCYVFFFWFMKWTRAGRKIYAVGSNSSAAEVSGINAKNINLLVYTIMGILAGLGGALQVSIYASAMPDMQYGGEMDVIAACVIGGVSMSGGRGTVMGALLGSLILATIAKALPLVGIGALWQNTIKGVLILVVVVVNVVLQRIADRNALKGREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XIU1</accession>
    <name>A0A173XIU1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase YdhF</fullName>
            <ecNumber evidence="2">1.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ydhF</name>
        <name evidence="2" type="ORF">ERS852478_00315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199563.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50817">
        <property type="protein sequence ID" value="CUN50817"/>
        <property type="gene ID" value="ERS852478_00315"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN50817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="298" mass="33140" checksum="29B15D8F0AE4024F" modified="2016-09-07" version="1">MKYTSLNENLKFSRIIAGCMRTLDAGMDGNKLRNFVHNCMDMGIDTFDHAPVYGAGRCEKIFGDEVLRKDPELRSKIKIVTKAGIILPGQKGNKHIFYDSTKSNLLAEMDASLNRLGTDHVDLLLIHRPDVLSNPEETAEALTEIVKAGKALNVGVSNYEPAQFEALQKYLPYKLVANQMEFSVKATYNFFNGVVDNAQMNKTALMAWSPLGGGSVFKGEDEQSVRLRTVLETIAKEHQTDIDVVMYAFVLKHPAEIMPITGTMNVGRVKNAVDALELDLTYDEWYAILAASRGFDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XJ68</accession>
    <name>A0A173XJ68_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rnhA</name>
        <name evidence="3" type="ORF">ERS852478_00332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199571.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51300">
        <property type="protein sequence ID" value="CUN51300"/>
        <property type="gene ID" value="ERS852478_00332"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="72"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN51300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="218" mass="23818" checksum="9422BF3EDD053435" modified="2016-09-07" version="1">MAKKKIYAVRKGHKTGLFATWAECQKAVSGYSGAEFRGFTEKEEALAFLNMETTGNVSGDKAKEAAGIVEVPENMVIAYVDGSFEKSIGRYAFGCVILTPDGQEIRKSGSGSDSAGVAIRNVAGEMLGSMTAVNWAIENKYPAVEIRYDYEGVEKWVTGVWRAKTPLTSKYAAHMQEAGKKIKISFCKIAAHTGNHYNEEADQLAKSALLKMDEEVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XK34</accession>
    <name>A0A173XK34_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_1</name>
        <name evidence="7" type="ORF">ERS852478_00314</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199636.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50788">
        <property type="protein sequence ID" value="CUN50788"/>
        <property type="gene ID" value="ERS852478_00314"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN50788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="279" mass="31309" checksum="B8D0689EF8F47DDB" modified="2016-09-07" version="1">MKKKTQRTVGWIAFYLFVIIFVVLLLLPFIWQFLTSVKPLNEIAEMPAKWIPSHIHGDFYVNVFTKHPFARYMLNSLIVATTATLLSLLVGASAAYALSRLHFKGRTVLLMVILGVSMFPTIATLSPLYLILKNMNLLNTYRGLILTYIGFSLPMAIWLMTNFFSQIERGFEEAAAIDGCSYFQTFTKIMLPLIKPATFSVGLLVFINCWNEYLYSLTFMSKDNMRTVPVGIALFPSNYQLPWGDMAAASIVCTLPLIALVLIFQKNIVAGLTTGGMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XT47</accession>
    <name>A0A173XT47_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycine/sarcosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.156</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.156" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199621.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54450">
        <property type="protein sequence ID" value="CUN54450"/>
        <property type="gene ID" value="ERS852478_00435"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017174">
        <property type="term" value="F:glycine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052730">
        <property type="term" value="F:sarcosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="41"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN54450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="270" mass="30669" checksum="27B9292C8C4D5152" modified="2016-09-07" version="1">MESYGRFAGVYDVFMDNVNYREWADYIIETLAQDGIRDGLVLELGCGTGTVTEMLADAGYDMIGIDNSEEMLAEAMEKRAESGHDILYLLQDMQDFELYGTVRAVISVCDSMNYLTDEEDLEYLFALVNNYLDPGGLFIFDMNTVHKYRDVIGDTTIAEDREDGSFIWENSYDRENALNVYELALFLPREDGLYEKCEEEHVQKAYSIEAIKAMIVKAGMELVAVCDAYTHNPGDENCERLTFVAREHGKSAQNGYHGKIPEKPETHRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y335</accession>
    <name>A0A173Y335_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyn operon transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cynR_2</name>
        <name evidence="3" type="ORF">ERS852478_00507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199685.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57656">
        <property type="protein sequence ID" value="CUN57656"/>
        <property type="gene ID" value="ERS852478_00507"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN57656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="311" mass="35712" checksum="465DDE93FFBDBC68" modified="2016-09-07" version="1">MFQGMEYIYEVYKEKSFSKAAAALFISQPSLSANVKRVENRIGYPIFDRSTKPLQLTEVGKHYIEAVEKVMDIENNLENFLLDLGNLKTGTLNVGGSNFFSSWILPPLIADFSQKFPHVQISLVEESTAKLSQFLQAGKLDLVIDNCILDNQIFEHYTYQKEQLLLAVPKNYSVNTRLQEYQIPIEEIRNGQFRSSHIPSVPLNKFENEPFIILRSDNDTGKRALTICQENHFSPSVVFRLDQQMTAYNIACLGMGITFIGDLLLSRVPTNSELIFYKLPGQSSKRTVFFYWKKGRYISRAMKEFLKLPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YA70</accession>
    <name>A0A173YA70_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">UvrABC system protein A</fullName>
            <shortName evidence="14">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">uvrA</name>
        <name evidence="17" type="ORF">ERS852478_00604</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199722.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60774">
        <property type="protein sequence ID" value="CUN60774"/>
        <property type="gene ID" value="ERS852478_00604"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="608"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="14">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="14">
        <location>
            <begin position="745"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <begin position="646"/>
            <end position="653"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUN60774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="946" mass="104692" checksum="5F55D1A735204DBF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YD02</accession>
    <name>A0A173YD02_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysozyme M1</fullName>
            <ecNumber evidence="6">3.2.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">acm_1</name>
        <name evidence="6" type="ORF">ERS852478_00614</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706131.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61107">
        <property type="protein sequence ID" value="CUN61107"/>
        <property type="gene ID" value="ERS852478_00614"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018337">
        <property type="entry name" value="Cell_wall/Cho-bd_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01473">
        <property type="entry name" value="Choline_bind_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016101" evidence="5">
        <location>
            <begin position="33"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN61107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="485" mass="54970" checksum="205BBFE6FBBD1A4D" modified="2016-09-07" version="1">MKRDFLKIRKRLIVGCLAAAIAVAQPVSSVFANPHYDRRDTVAEEEFIYSARTSGTESSRKKVNSKAWKKINGVCYNGSGEIIPGAITRGMDVSEWQGNIDWKQVKRSDIDFAFVRISYGLTHEDYTYDENMTNAELAGVPTGTYVYSTALSTTTALKEAQLAISKMQGYKVSYPVVYDLEYAKASKLSAKTVSEMALTFCNEVRRAGYYPMVYCNTNWYDNYIDWSLLSGVDVWIARYGDTIQAPDKERYNYTIWQSTDGNRESGLNSTSGLVAGIPAGNDVDMDFGYVDYTKKITPRWKSLHSYVPAMKPDTGSNDGSQEQTGLHQENGKYYYVNENGERVSDQWVTVNGKTYYISSDGYALMGMKKVDGKCYWFHTKSGYMFKNRRVTRSTGDIYYFGSDGVRCENGMYKVREKSGEHTYYFRKNGKAYKGWLTLNGKKYYFYKGSSALSGTRAENITLTSSNRIVSVFDGNGVCTRQYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YE51</accession>
    <name>A0A173YE51_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glucan-binding repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_00613</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61068">
        <property type="protein sequence ID" value="CUN61068"/>
        <property type="gene ID" value="ERS852478_00613"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016115" evidence="4">
        <location>
            <begin position="25"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="701"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN61068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="861" mass="94002" checksum="233D2CB795296E14" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YIS2</accession>
    <name>A0A173YIS2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative HAD-hydrolase yfnB</fullName>
            <ecNumber evidence="1">3.-.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yfnB</name>
        <name evidence="1" type="ORF">ERS852478_00658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.-.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN63639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380274.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63639">
        <property type="protein sequence ID" value="CUN63639"/>
        <property type="gene ID" value="ERS852478_00658"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011951">
        <property type="entry name" value="HAD-SF_hydro_IA_YjjG/PynA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02254">
        <property type="entry name" value="YjjG/YfnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN63639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="227" mass="26097" checksum="69C6F279D79DEC1B" modified="2016-09-07" version="1">MVETLFFDLDNTLLDFNRAERAAIAKTLKSFHIAPEPSVLKRYSELNLAQWKLLEQGKITRDQVKLRRFRLLFAELNVDIPAKEAAHTYETLLAQGHYFIDGAEELLETLYGQYRMYLVTNGTLSVQKGRLKSSGISRYFEDIFISEELGYNKPGREYFNCCFSRIPDFHKETAVIIGDSLTSDIQGGINAGIRTIWFNPSHEKTSEIIPDHEFDSLMKLPELLSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YK18</accession>
    <name>A0A173YK18_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">btr_2</name>
        <name evidence="7" type="ORF">ERS852478_00683</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052672.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64482">
        <property type="protein sequence ID" value="CUN64482"/>
        <property type="gene ID" value="ERS852478_00683"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="431"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN64482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="531" mass="61512" checksum="6B1D9AD1F13B73CD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YL02</accession>
    <name>A0A173YL02_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_6</name>
        <name evidence="7" type="ORF">ERS852478_00670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199750.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64017">
        <property type="protein sequence ID" value="CUN64017"/>
        <property type="gene ID" value="ERS852478_00670"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN64017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="274" mass="30656" checksum="23DDC9A79D1BA38A" modified="2016-09-07" version="1">MSARDKANRVLIHVILILVSITMLVPFLWMILTAFKTMTEATSVNPFVILPSTWRWDSFKEVIENMDFLHLYINTLLLILGRVVCAVLTATLAGYAFGRLNFRGKNLMFSLVLFQMMVPGQIFIIPQYLMVSKMGMLNTIFALVFPGIVTAFGTFLLKQAYMGLPKDLEEAARLDGCNIGQTFLFIMAPLTRSSMVALGIFTAVFAYKDLMWPLICNKDVMPLSAALAKMQGQYTNNYPQLMAASLLACIPMIVLYLIFQKQFIEGIATSGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z2S9</accession>
    <name>A0A173Z2S9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenosine nucleotide hydrolase NudE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199816.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69485">
        <property type="protein sequence ID" value="CUN69485"/>
        <property type="gene ID" value="ERS852478_00826"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN69485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="204" mass="23458" checksum="3B52A50BA92AF14E" modified="2016-09-07" version="1">MGQIHNIEKLTDCKFLNLYHLNATSIHNTPVSYFVASRAKSINELKIKTGKNTPDGVIIYSLYGEKKDRVVLVRQYRYAIGGYIYEFPAGLVEPNEEFHEGAVREMYEETGLKFTPLKVDPAFEKPYFTTVGMTDESCATVYGYAEGEISKDAQEDTEEIEVVLADREEVKRILREENVAIMCAYQLMHFLRDEEPFAFLKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z6K0</accession>
    <name>A0A173Z6K0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6128 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199826.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71423">
        <property type="protein sequence ID" value="CUN71423"/>
        <property type="gene ID" value="ERS852478_00860"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030VT8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046131">
        <property type="entry name" value="DUF6128"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19623">
        <property type="entry name" value="DUF6128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6128" evidence="2">
        <location>
            <begin position="251"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN71423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="347" mass="39008" checksum="3913D89B1A63DFEB" modified="2016-09-07" version="1">MAGYRRFIAYVYDYESGKKGSNCGFIKVEVKDQQCSVEIHLHCPGLPENVKCNIYGFTRKDGLINGILLDTCETEKETVECLIITDATDMNDSGVAMGKLGGMIITSDTGGFFGTEWDDQPIRPENFHEIKAMPDADIPESAKITSQKPEVPADMVLQEMPEELEDISEKPEDTSLTKVPDDSLSIEPSANIPAQGTSDNKPGTESSYISDNTVEDSNSSENAGNPVPERNAENRKTSAEFSPFSDGELISAWKIHLDDLKHFPRHYCALRNNRFLQYGHYNFGYLLLGQRNNGQYILGVPGVYNQQERFMANMFGFPYFKESSYIEIPKMRGGYWYRLIDAPDSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZBS9</accession>
    <name>A0A173ZBS9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDSL-like Lipase/Acylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199843.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73129">
        <property type="protein sequence ID" value="CUN73129"/>
        <property type="gene ID" value="ERS852478_00918"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="1">
        <location>
            <begin position="5"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN73129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="232" mass="26597" checksum="B3B0F964100CEA29" modified="2016-09-07" version="1">MQIICLGDSITDCNHLFEDFPLGNGYVQILSEMFRNQPPSFSISADTVRRSSSAVQLTDRSTGAIHFRNCGIDGFTVARVLENIRQHRIFLHCSPVITLLIGINDIGLIMNTDRTDSQKEQMMREFATHYNELLNLLTADARQVILMEPFIFPHPEEYETWIPYVHTMSDIIRQLSVRFRLPFLPLHNYFNKEATQSGFDAITTDGIHLTLYGHKLLAEKLFPLLQSIDNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZKD2</accession>
    <name>A0A173ZKD2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Catabolite control protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ccpA_3</name>
        <name evidence="5" type="ORF">ERS852478_00997</name>
        <name evidence="6" type="ORF">GT728_13470</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
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                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
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            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BIOML-A1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75625">
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        <property type="gene ID" value="ERS852478_00997"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG1609">
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    <dbReference type="Proteomes" id="UP000095431">
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HTH_LacI"/>
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        <property type="entry name" value="LacI/GalR-like_sensor"/>
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        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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        <location>
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    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
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    <sequence length="329" mass="37335" checksum="ABC517364003A7F5" modified="2016-09-07" version="1">MGITTKEIAKICGVSRTTVHRALNNTGRISEKTKRMILETAEKNGYRPDLLATGLAKGKTYYIGVVVMDVNNRYFSQMLSALEIEARERGYFINITLHQNDKEIEKEQLCKLADYHVDGIILSSVNKGEEYKKFIESLNIPVVTIDNKIADKIPFVTVNGRSAISKAVCEIAESGYEKVIFVCPPLAEKNLENIYVHEERTAGFKEAVKKIHGLEYVIIGNWDYQKQAKKELEKSEKKTAFLCTGDMFALNLIRMFEKNGKRAGQDYGIMGYDNIDFLEYVTPRLTTIDNHVEKVAEEAFNLLLQLMENKNVAETERILETVTVQGETI</sequence>
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    <accession>A0A173ZVM7</accession>
    <name>A0A173ZVM7_9FIRM</name>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN80294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="264" mass="31295" checksum="BFEBBFE257914D87" modified="2016-09-07" version="1">MSGYILCQTKKAQRPYFIENISMNIYSIEELCYYLYHNLYLADHTVFNEELCNWLRDELELVHLAAKLKQNLERNVSVEEMIYPVFKEINYLTYEEMKGFNSRIVTYGKEKAAVRQKRKGDALTENGMYVNAIRVYQKLLEREDLSEQRKGFAASVRYNLGCAYSYLFQMEKAQECFLEAYREEHSKEALKAYIIAYSSVHDKTDYDKVMEELEVDEELKKDIKEEIRQSLKAFESVPEEKTDEKNLDALLERLMKDYHRSTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZX88</accession>
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        <recommendedName>
            <fullName evidence="1">DUF5716_C domain-containing protein</fullName>
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    <gene>
        <name evidence="2" type="ORF">ERS852478_01103</name>
        <name evidence="3" type="ORF">ERS852523_00425</name>
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    <organism evidence="2 5">
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    <reference evidence="2 5 6" key="1">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BIOML-A1</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CUN80259">
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    </dbReference>
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        <property type="gene ID" value="ERS852523_00425"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="415" mass="47342" checksum="664433C46C3B06A2" modified="2016-09-07" version="1">MNEIRDLIVGIDFGKEYSQICYYDRKGDEARSLSMKAGGNQYEAPCILCWRPEQKDYCVGLEADYFVREKGGVMIDDVYGICEKSDSVLVEGQELAPWEILAQFLQGMLKFLGVAELVKNTKCVAVTLPGLTEIQVENFQKAFEIIGFPHEKYMLLDYGESFYYYVLSQKRETWNRSVGWYAFTPENVSFRKMTMNGATKPVTVKLEEAVETELPAEGQERDSEFGKFVQKTLGRDLFSSIQITGDGFSQDWAEQSVRLLCYQKRKVFYGNNLFAKGACAAGKEKTENKALKGYRFLSDSLVMADVGMEMRVMGSPTYYPLIEAGNNWYDSKASCEFILDDTEELVFIVSTYHRPEKRRVGMMLPGIPLRPDKTTRLRLELQYVSSTECKVTVTDLGFGEMFPSSGKTWTETVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZXJ0</accession>
    <name>A0A173ZXJ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Major Facilitator Superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
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            <taxon>Blautia</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79898">
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        <property type="gene ID" value="ERS852478_01094"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN79898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="408" mass="44201" checksum="0D9639CB5C9BEDDB" modified="2016-09-07" version="1">MIFKCRNSIKKTDYHKTKIACYMGFITQAIAANFAPLLFLKFHSDYHISLGNIALISTFFFFTQLLVDLFCAKFVDHIGYRVCIVTSEIFSALGLLGLAFLPDFLPDPFIGIICSVIVYAIGSGLIEVLCSPIIEACPFENKEATMSLLHSFYCWGAVGTILISSLFFLIFGIDNWKWLAVIWAIIPAVNTYNFMTCPIEHLVDNGSGMGIKNLFSKPFFWVAICLMICSGASELAMAQWASAYAEAALGLSKALGDLAGPCMFAVTMGISRIIFGKYGEQLDLMKFMGGSGILCVVCYLLAALSSSPIIGLIGCIACGFSVGIMWPGTISISSKTFPTGGTAMFSLLAMAGDLGGSIGPGIVGRITQNAGNNIRIGMGFGLIFPVILLFMLFLLYRKKSIQPQISKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZZR7</accession>
    <name>A0A173ZZR7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">accB_1</name>
        <name evidence="7" type="synonym">accB</name>
        <name evidence="9" type="synonym">accB_2</name>
        <name evidence="9" type="ORF">BWLFYP14_03090</name>
        <name evidence="6" type="ORF">ERS852478_01144</name>
        <name evidence="8" type="ORF">GT712_03485</name>
        <name evidence="7" type="ORF">GT728_00735</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 13">BIOML-A1</strain>
            <strain evidence="8 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059530.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81734">
        <property type="protein sequence ID" value="CUN81734"/>
        <property type="gene ID" value="ERS852478_01144"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00531">
        <property type="entry name" value="BCCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="77"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN81734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL31759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS88174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="153" mass="16815" checksum="C53E553214DA7C06" modified="2016-09-07" version="1">MELANILELIHAVSDSDLTEFNLQDDTLNISMSKEKTIVQQMAVNTDPADAQQYQPVVQQAVHVESVNAVNDEVQTGSVVKSPLVGTYYAASSPENPPFVKIGDKVSKGQVLGIVEAMKLMNEIESEFDGTVKEILVENEQMVEFGQPMFVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A1J1</accession>
    <name>A0A174A1J1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage III sporulation protein SpoAB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199941.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82023">
        <property type="protein sequence ID" value="CUN82023"/>
        <property type="gene ID" value="ERS852478_01153"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503181X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014198">
        <property type="entry name" value="Spore_III_AB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09548">
        <property type="entry name" value="Spore_III_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN82023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="172" mass="19890" checksum="398C232036F6A565" modified="2016-09-07" version="1">MLRTVGLCVIVISGVGCGFAMSNELGRRKKMMEMILRMIILLRGEIRYGNKSLYDAFTGASGKLEGKYREFFILTAQKMKEKKGDSFGTIFRESAGKCLDLDCLSQEERDRFYSLGDQLGYLGLDMQLKQMDLMEKETEYEIRELRKDFCEKRKLYRSMGILGGIFVAVFFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A743</accession>
    <name>A0A174A743_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">23S rRNA (Uracil-C(5))-methyltransferase RlmCD</fullName>
            <ecNumber evidence="6">2.1.1.189</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rlmCD_2</name>
        <name evidence="6" type="ORF">ERS852478_01191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.189" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199950.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83326">
        <property type="protein sequence ID" value="CUN83326"/>
        <property type="gene ID" value="ERS852478_01191"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN83326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="396" mass="45176" checksum="51F7E1F5CE6397F9" modified="2016-09-07" version="1">MEEKVTKCSVSKKCGSCQYQGVPYKEQLSAKQKRMKKLLGKFANVKPIIGMDDPFYYRNKVHAVFDRDKKGNIICGTYEAKTHKVVPIEECMIEDKISQEIIRTIRDMLKSFRIKTYDEDTGYGLLRHVLVRRGFSTDEIMVVLVIGSPIFPSKNNFVKALRKKYPQITTVVLNVNDKKTSMVLGERDIVIYGKGYIRDTLCGCTFRISPQSFYQVNPVQTEILYKTAIEYAGLGRKETVIDAYCGIGTIGLVAAKRAKNVIGVELNPDAVRDARINAKENKITNARFYQGDAGEFMENMAENGEHADVVFMDPPRTGSDKKFMTSVIKLNPSRIVYISCGPETLARDLEYLTKHGYDVRKIQPVDMFSFTDHCENICLLTKKFEKQTKNQNEYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A8W1</accession>
    <name>A0A174A8W1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_01226</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN84643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84643">
        <property type="protein sequence ID" value="CUN84643"/>
        <property type="gene ID" value="ERS852478_01226"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1893">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00004"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="3">
        <location>
            <begin position="12"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="4">
        <location>
            <begin position="188"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN84643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="311" mass="34645" checksum="C6FDE895481F77B5" modified="2016-09-07" version="1">MKAGQKINMKYLIIGAGGTGGVTGYYMKKAGKDVTLIARGEHLKKIQKQGLTLEKMWDKTEENISIPATDMEHYAEHPDVIFVCVKGYSLQETIPFIKRIARKNTIVIPVLNIYGTGGKMQKELPDLLVTDGCIYVSANIKEPGKLLQHGQILHIVFGVRDKAEFRPELKEIQKDLCDSHIDGTLSENIRREALEKFSYVSPIGAAGLYYHATAADFQKEGEARELFKTMVKEIAALAEAMGVPFQKDMAEVNLKILSNLAPEATTSMQRDIMAGKQSEIDGLVYEVVRMGEEYHVPVPAYEKVAEKLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AE75</accession>
    <name>A0A174AE75_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">srrB_2</name>
        <name evidence="8" type="ORF">ERS852478_01230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN85805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_006857258.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000068.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN85805">
        <property type="protein sequence ID" value="CUN85805"/>
        <property type="gene ID" value="ERS852478_01230"/>
    </dbReference>
    <dbReference type="GeneID" id="61431740"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="195"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN85805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="409" mass="46019" checksum="06E96398E8BB06BA" modified="2016-09-07" version="1">MNFLHDKHSRYYCIFIVTLVLLLFLMGIAVIDTQTAATKEMFLTHNNAIATSLLEEGISKEVIATALMNTEAGTTGNKFLAEIGLSNSTDIENLPYVSAVKNTILTSLFVMLFLWTLLLFLGTMLFLYRRERLYRESENIIKDYIDGNYTVHLPQSNEGTIYQLLSSVDQLATMLQAKNDTEQKTKEFLKNTISDISHQLKTPLSALMMYQEIIENEPENFETVKEFSLKIGTALKRMEQLIQSMLKITRIDAGSISFEKSNYSIPNIINHAISELTTRADNEKKEIVIDGDLEQMLYCDIEWTGEAIGNIIKNALDHTDTGGKISISWEQTPAMIRIFITDNGHGISQEDIHHIFKRFYRSKNTSESQGIGLGLPLAKAIVEGQGGILSVQSELLQGTTFTLSFLTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ALY4</accession>
    <name>A0A174ALY4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IMP cyclohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380752.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88456">
        <property type="protein sequence ID" value="CUN88456"/>
        <property type="gene ID" value="ERS852478_01304"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006188">
        <property type="term" value="P:IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020600">
        <property type="entry name" value="IMP_cyclohydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036795">
        <property type="entry name" value="IMP_cyclohydrolase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07826">
        <property type="entry name" value="IMP_cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75569">
        <property type="entry name" value="SSF75569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP_cyclohyd" evidence="1">
        <location>
            <begin position="15"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN88456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="237" mass="26708" checksum="225CC94E894124C4" modified="2016-09-07" version="1">MEMLSLEKELKENSYPGRGIVIGRSADGKKAVTAYFIMGRSENSRNRVFVEDGEGIRTQAFDPSKLTDPSLIIYAPVRVLGNKTIVTNGDQTDTIYEGMDHQLTFEQSLRSREFEPDGPNYTPRISGVMHVENGKFNYAMSILKSNNGNPDACNRYTFAYENAIAGEGHFIHTYKCDGNPLPSFEGEPKLVAIPDDIDEFAELLWNSLNEDNKVSLFVRYIDIETGKYESKIINKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AM95</accession>
    <name>A0A174AM95_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01648</name>
        <name evidence="2" type="ORF">ERS852478_01308</name>
        <name evidence="3" type="ORF">ERS852523_00900</name>
        <name evidence="4" type="ORF">GT712_09445</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000007">
        <property type="protein sequence ID" value="CUP20923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380754.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000027.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000047_gene1265"/>
    <dbReference type="EnsemblBacteria" id="CUN88566">
        <property type="protein sequence ID" value="CUN88566"/>
        <property type="gene ID" value="ERS852478_01308"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20923">
        <property type="protein sequence ID" value="CUP20923"/>
        <property type="gene ID" value="ERS852523_00900"/>
    </dbReference>
    <dbReference type="GeneID" id="66494934"/>
    <dbReference type="eggNOG" id="ENOG50332G5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046088">
        <property type="entry name" value="DUF6106"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19601">
        <property type="entry name" value="DUF6106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN88566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP20923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="167" mass="18599" checksum="A8629452402CA02B" modified="2016-09-07" version="1">MGDLYSELLVKKDKTAKDSLLKYGLIVLTVLAVFAGLIITPLALIIAVALGIACYFVIPKTDVEYEYLFINGDFDIDMIMSKTKRKKVKSFKLSEADLAAPLDSHRMDYYNGNQNMKVLDFSSGNPEHKRFGVITRLDGNLCKIILEPDEALAQAMKNSAPSKVFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AMQ2</accession>
    <name>A0A174AMQ2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">DNA-protecting protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smf_1</name>
        <name evidence="4" type="synonym">dprA</name>
        <name evidence="5" type="ORF">BWLFYP14_01653</name>
        <name evidence="3" type="ORF">ERS852478_01313</name>
        <name evidence="4" type="ORF">GT712_09470</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_062807261.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88748">
        <property type="protein sequence ID" value="CUN88748"/>
        <property type="gene ID" value="ERS852478_01313"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041614">
        <property type="entry name" value="DprA_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17782">
        <property type="entry name" value="DprA_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DprA_WH" evidence="2">
        <location>
            <begin position="250"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN88748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="305" mass="33578" checksum="994171590A5A7F83" modified="2016-09-07" version="1">MERTDVKNNHTEEYSTGQIRCIEKSDPEYPQIMKQYSSMPAKLYVKGRLPDPKRRTVAVIGARMCSPYGRMQAFRYAKALSVAGVQIISGMALGIDSEGHKGALEGKMPTFAVLGSGVDVCYPKSNRKLYERILWENGGIISECPLGSGPVSWHFPARNRIISALSDAVLVVEAKENSGSLITAGFALEQGKMVYAIPGAVTDELSRGCHKLIYDGAGIAYCPEIMLEELGISMEKVTQNGEKNNLGLARDLNMVYSCLDLRPKNPDYIVRKTGFSPAQVSNCLVELTLRGLIRESGRHYYVKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ANL1</accession>
    <name>A0A174ANL1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TelA-like protein SA1238</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TelA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200011.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89056">
        <property type="protein sequence ID" value="CUN89056"/>
        <property type="gene ID" value="ERS852478_01321"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008863">
        <property type="entry name" value="Toxic_anion-R_TelA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38432">
        <property type="entry name" value="PTHR38432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05816">
        <property type="entry name" value="TelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026508">
        <property type="entry name" value="TelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="123"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="350"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR026508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN89056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="379" mass="43502" checksum="D1B4DF2A2D1726C3" modified="2016-09-07" version="1">MGNEFKDFEMETPSLTLEPDLGEFEKKEEVIPKKQLQKEEVPVLTPEEQKMVNDFAAKIDIENTNQILQYGAGTQKKMADFSDTALENVKTQDLGEIGELISNVVGELKDFDVQEEGKFFGFFRKQTSKIENLKNKYDKAQANVEKITDSLQQHQVRLMKDSAMLDKMYEQNLNYFKELTMYILAGKKKLEETRNGKLAEMKNKAALSGLPEDAQAARDLDEKCSRFEKKLHDLELTRTIAMQTAPQIRLIQNNDTVMVEKIQTTIVNTIPLWKSQMVLALGIAHSAEAAQAQRQVTDITNELLRKNAETLHMATVETAKESERGIVDLETLQKTNADLIQTLDDVMRIQMEGRQKRQAAEMEMHRMEEELKRKLLEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174APX9</accession>
    <name>A0A174APX9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltose/maltodextrin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">malX</name>
        <name evidence="2" type="ORF">ERS852478_01358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200031.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90293">
        <property type="protein sequence ID" value="CUN90293"/>
        <property type="gene ID" value="ERS852478_01358"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017828" evidence="1">
        <location>
            <begin position="28"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN90293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="428" mass="46484" checksum="783D1FCC2D8A0E1D" modified="2016-09-07" version="1">MKKKVFATLLAVSMIASMVPAAVSVQAADGDSIRLVNGKIEVDAQLKKLAEMYEKETGTKVEIESMGGGIDIQGTLKGYYQSDNMPDIFVNGSGADFANWTDMLVDMSDQKWASDTDAAYVDESQGTIGFPYTTEAIGLAYNKDILDKAGVDPSTLTSPDAIQKAFETIDSKKDELGLTAVVGYAAEPVNLYWSTGNHLFGTYLDEGLDRDDTTYIDMLNDGGKLDEARFTDFAKFVGLLNQYSDPALLVSGTYDQQILNFSSGKYAFVTQGSWIGATMVGDDADAYKEAGNFEVGMIPYAFEDGQDTILTSSPSWWSVYKDGNVEAAEAFLQWLTTDEAQEVLVKEAGFVSPFKSCTIVGDDPFAQTITDYQNAGKTSAWHWSIPGFKEGIAQNYTGQVFADYAAGSLDEAGFIKTMQQVLESAYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AY86</accession>
    <name>A0A174AY86_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200074.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93532">
        <property type="protein sequence ID" value="CUN93532"/>
        <property type="gene ID" value="ERS852478_01420"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN93532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="104" mass="11785" checksum="45340609145B24A1" modified="2016-09-07" version="1">MKKFKEKRMASYVFRSNELIQEGKTKEAAELIGKGLGYYSSNIIHAITPYATADAGLISTVLCHLASEIEEKNSGAKEMREWAETHVEKPELKEIKRIKKPNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BC60</accession>
    <name>A0A174BC60_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97315">
        <property type="protein sequence ID" value="CUN97315"/>
        <property type="gene ID" value="ERS852478_01530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN97315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="179" mass="19963" checksum="71DAF8440E0AA59F" modified="2016-09-07" version="1">MAPLGKQADFRVSSRPVAQPVKPCGAFAVQFQPDKGHGLKGEAPRLNQTQRLRELGESRPQKQEAVFFRQRFHRQGAQLVNAHGGIVLFCCTLYCFLFISPRRVGVKDVVGFLLCFFDSWYSSCLSMCGKYGFRYAAGLEQTEAKQNGIAHTAPDCTGYVVSGSDLLDQHRINPDNHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BEY3</accession>
    <name>A0A174BEY3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">phoR_3</name>
        <name evidence="7" type="ORF">ERS852478_01559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN98320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004611592.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000097.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98320">
        <property type="protein sequence ID" value="CUN98320"/>
        <property type="gene ID" value="ERS852478_01559"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="80"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN98320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="292" mass="34102" checksum="9423522CC3C957D4" modified="2016-09-07" version="1">MLYFLLICFIFILAFSLFSIIRTIRNINKQIKQQRKIRVSLSNRDIEELAYAINQKDNLHKKLQVQIKQEEEQLKQSISNISHDLRTPLTSIQGYLTLLQECEDKQEQGQCIKIIKAKTDYLTDLVQEFYDLSVIENEQVDVECERVDINRIVTDCLIEKYYEFGEIQPTIQTENTPVWIYGNNLICKRIIENLIVNALRYSDNYIEVSINQKGVFTIKNSTKSLDDIDVNLLFNKFYTVDKSRTKGSSGLGLYIVKELLKKIDGKIENVSYEKNILSISICFPLYNDKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BJ55</accession>
    <name>A0A174BJ55_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phenyloxazoline synthase MbtB</fullName>
            <ecNumber evidence="6">6.3.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mbtB_2</name>
        <name evidence="6" type="ORF">ERS852478_01612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO01101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057322.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO01101">
        <property type="protein sequence ID" value="CUO01101"/>
        <property type="gene ID" value="ERS852478_01612"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041464">
        <property type="entry name" value="TubC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044894">
        <property type="entry name" value="TubC_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18563">
        <property type="entry name" value="TubC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1030"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="4">
        <location>
            <position position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO01101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1105" mass="127513" checksum="B81D1EE64DA9ACC9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BJN4</accession>
    <name>A0A174BJN4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein AC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sigF_1</name>
        <name evidence="2" type="ORF">ERS852478_01576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99788">
        <property type="protein sequence ID" value="CUN99788"/>
        <property type="gene ID" value="ERS852478_01576"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN99788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="78" mass="8760" checksum="4E60EDD175C2B4B0" modified="2016-09-07" version="1">MDHTLALIMKSQQGDKEARDTVFKENAGLVYSMAKRFAGRSVEMEDIVQIGSIGLLKAIDRFDISYDVKFSTYAVPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BRG7</accession>
    <name>A0A174BRG7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stage V sporulation protein AD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">spoVAD</name>
        <name evidence="1" type="ORF">ERS852478_01648</name>
        <name evidence="2" type="ORF">GT712_09035</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994117.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02280">
        <property type="protein sequence ID" value="CUO02280"/>
        <property type="gene ID" value="ERS852478_01648"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010894">
        <property type="entry name" value="SpoVAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038369">
        <property type="entry name" value="SpoVAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07451">
        <property type="entry name" value="SpoVAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011570">
        <property type="entry name" value="SpoVAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO02280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS89212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="360" mass="38572" checksum="1A0E8644939C88B6" modified="2016-09-07" version="1">MNRQMTCGTSSISFQNPVFVQSCASVVSRKEGEGPLGAYFDTICEDPMFGTDTWEAAESTLQKQAALLAIKKNGLTCSDIQLLFAGDLLAQTSASSFGTADLKIPFYGLFGACSTMGESLSLGSMCIDGGYGKYILCATSSHFASAEKEFRFPLGYGNQRPLSATWTVTGAGACILGYEPPPRPDNKTLNTLRNRNICAVITGITTGRLIDFGFRDSLNMGACMAPAACDTIARNLQDFHRKPSDYDAIFTGDLGMVGQTILFDLLTEKGFDISSVHQDCGMLIYDPQTQDTHSGGSGCGCAASVLAGYILPGIIQKKWKRILFVPTGALLSKVSFNEGDPIPGIAHAVVIEQYRVPDMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BTT7</accession>
    <name>A0A174BTT7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplX</name>
        <name evidence="10" type="ORF">BWLFYP14_00266</name>
        <name evidence="6" type="ORF">ERS852478_01668</name>
        <name evidence="7" type="ORF">ERS852523_01284</name>
        <name evidence="9" type="ORF">GT712_08935</name>
        <name evidence="8" type="ORF">GT728_04745</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="4">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707266.1">
        <property type="nucleotide sequence ID" value="NZ_WQPZ01000191.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2973"/>
    <dbReference type="EnsemblBacteria" id="CUO02956">
        <property type="protein sequence ID" value="CUO02956"/>
        <property type="gene ID" value="ERS852478_01668"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33334">
        <property type="protein sequence ID" value="CUP33334"/>
        <property type="gene ID" value="ERS852523_01284"/>
    </dbReference>
    <dbReference type="GeneID" id="66496131"/>
    <dbReference type="eggNOG" id="COG0198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO02956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP33334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL32527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX67425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="103" mass="10938" checksum="968B3074B15542C0" modified="2016-09-07" version="1">MSAMKIKKGDTVKVIAGKDNGKEGKVLAVNAKDNTVVVENINKVTKHSKPSAANQQGGIITKEAPLHISNVMLVVDGQATRVGFQMDGDKKVRVAKKTGKVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BZH7</accession>
    <name>A0A174BZH7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3 5">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">moaC</name>
        <name evidence="7" type="ORF">ERS852478_01738</name>
        <name evidence="8" type="ORF">GT728_05770</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaC family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000009">
        <property type="protein sequence ID" value="MZL32727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200207.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06027">
        <property type="protein sequence ID" value="CUO06027"/>
        <property type="gene ID" value="ERS852478_01738"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="6">
        <location>
            <begin position="16"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="76"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO06027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL32727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="158" mass="17077" checksum="805CD2CEAE246375" modified="2016-09-07" version="1">MSQGFNHFDENGNAVMVDVSGKNVTYRTAVATGEIHVGEAIMEAVKEGSVKKGDVLGVARVAGIMGVKRTSELIPMCHPLPIQKCSVDYELDETNGIIRAFCTVKTEGKTGVEMEALTGVQVTLLTIYDMCKAIDKHMVMSNIHLVEKTGGKSGDFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C6Q6</accession>
    <name>A0A174C6Q6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylamine methyltransferase corrinoid protein reductive activase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO07555">
        <property type="protein sequence ID" value="CUO07555"/>
        <property type="gene ID" value="ERS852478_01787"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027980">
        <property type="entry name" value="RACo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040506">
        <property type="entry name" value="RACo_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041414">
        <property type="entry name" value="Raco_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042259">
        <property type="entry name" value="Raco_middle_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14574">
        <property type="entry name" value="RACo_C_ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17650">
        <property type="entry name" value="RACo_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17651">
        <property type="entry name" value="Raco_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO07555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="577" mass="62242" checksum="63C5D218832774CB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C7Q2</accession>
    <name>A0A174C7Q2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">sn-glycerol-3-phosphate transport system permease protein ugpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ugpA_6</name>
        <name evidence="7" type="ORF">ERS852478_01826</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055054104.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08827">
        <property type="protein sequence ID" value="CUO08827"/>
        <property type="gene ID" value="ERS852478_01826"/>
    </dbReference>
    <dbReference type="GeneID" id="66495531"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="76"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO08827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="299" mass="33354" checksum="CF4419BBA8021BCF" modified="2016-09-07" version="1">MNSKKKGMSLLGKQRAAGWTFLAPATIMIAIMSFYPMIRAFIISLQTGAGANMRFADPIFSNYKRILADKVFQQSIVNTFLYLIIQVPIMLILAILLAQLLNNKDLKFKGFFRTCVFLPCATSLVSYSLIFRSMFATDGLINSILIKLGILSTGYNFLGNSASAKIVIILALIWRWTGYNMVFYLAGLQNIEYSVYEAAKIDGANGWKTFWKITVPLLKPTIIMTFIMSINGTLQLFDESVNLTKGGPANSTITMSHYIYNTCFINVPNFGYAAAMSFIIFIMVAVLAFINLKVGDTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C8K2</accession>
    <name>A0A174C8K2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="4">4.1.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fda</name>
        <name evidence="4" type="ORF">ERS852478_01807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200284.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08210">
        <property type="protein sequence ID" value="CUO08210"/>
        <property type="gene ID" value="ERS852478_01807"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="229"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="271"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO08210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="384" mass="41759" checksum="302962B0A2EAB562" modified="2016-09-07" version="1">MPLIPLRPLLETVDKYHFAQGAFNVNAVAQAKAAIEVHEMFRSAAILQGADLANGFMGGRTDFQNATLEDKKVGAKNIADAVKKYAENSPIPVVLHLDHGKNFDSCKAAIEGGYTSVMIDGSSLPFDENVELTREVVKYAHERGVSVEGELGVLAGVEDHVFSTTSTYTNPLKAIEFFKKTGVDALAISYGTMHGASKGKNVKLRKEIAIAIKECMMHEGIFGVLVSHGSSTVPKYIVDEINALGGNIQNAYGISIDELKAAIPCGIGKINVDTDIRLAVTRNMKEFFANHPEKRESQSIGEVYRLLEAKKEQFDPRAFLTPIMDTVMYGIIPDEDVAALMAVVEKGVKEAIGTLIVEFGSYGKAPLVEMASLDEMAERYRKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CA89</accession>
    <name>A0A174CA89_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_13</name>
        <name evidence="7" type="ORF">ERS852478_01825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08800">
        <property type="protein sequence ID" value="CUO08800"/>
        <property type="gene ID" value="ERS852478_01825"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="73"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO08800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="275" mass="31178" checksum="F95EE5BF19D1C891" modified="2016-09-07" version="1">MTKKNKSAIQRRLIPTYIFLIIVSFISVFPLYWMISAATNTSTDVSRGRIIPGSYFMENFRNLTSQQPLWRALGNSFFYAILTTVICLLVCSIAGYGFEVYHDKWKDRVFSILLLAMMVPQVATMVPLFKMFSKAGLLNTAVGFILPIISTPFMIMMFRQNARSFPVDIIEAARIDGLNEVRIFFQMFIPTMKSTYAAAAVITFMNAWNSYLWPKVIMTDNKAMTMPMLIANLITGYVTDYGMLMCGVLFCSIPTMIVFFVLQKQFAEGITGAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CFY6</accession>
    <name>A0A174CFY6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10406">
        <property type="protein sequence ID" value="CUO10406"/>
        <property type="gene ID" value="ERS852478_01853"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO10406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="39" mass="4338" checksum="1E03302CAFCF9D3A" modified="2016-09-07" version="1">MERTCVPIPSSDINAIMHLEICAPENKNNLKGLIRSVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CHR3</accession>
    <name>A0A174CHR3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor glcR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glcR_1</name>
        <name evidence="5" type="ORF">ERS852478_01927</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200444.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12773">
        <property type="protein sequence ID" value="CUO12773"/>
        <property type="gene ID" value="ERS852478_01927"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO12773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="247" mass="27300" checksum="D22DED412A87ECE5" modified="2016-09-07" version="1">MLTEQRFDIILKLLEERKSITVTELRELLDASESTVRRDITALDKAGKLTKVFGGAVALNHKVTAYEPTVAQKLELNKEEKQKIAKYAASLITPDDFVYLDAGTTTGLMLEYLKGVKAAFVTNAVSHAQTLAKMGIRVYLIGGELKSSTEAVVGSQAMQMIQMYHFTKGFFGTNGITRREGFTTPDTSEAIVKSTAMKQCKDVYILTDKSKFGEVSSVTFGGFTDAKILTEEIPEEYEDSKNILKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CJ30</accession>
    <name>A0A174CJ30_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-hydroxyglutaryl-CoA dehydratase component A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hgdC_1</name>
        <name evidence="5" type="ORF">ERS852478_01935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200450.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12957">
        <property type="protein sequence ID" value="CUO12957"/>
        <property type="gene ID" value="ERS852478_01935"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1924">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008275">
        <property type="entry name" value="CoA_E_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00241">
        <property type="entry name" value="CoA_E_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="4">
        <location>
            <begin position="305"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO12957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="559" mass="60962" checksum="FC4544E40535B399" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CNI4</accession>
    <name>A0A174CNI4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13328">
        <property type="protein sequence ID" value="CUO13328"/>
        <property type="gene ID" value="ERS852478_01948"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO13328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="57" mass="6696" checksum="A8EF627CC84310CF" modified="2016-09-07" version="1">MSDNMTKRAKEYMNADFVYEDYKNLAEAQKIADVEDVTAISERLIKQNMEAYKELTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CPE9</accession>
    <name>A0A174CPE9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mdeA_3</name>
        <name evidence="4" type="ORF">ERS852478_01983</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.11" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15202">
        <property type="protein sequence ID" value="CUO15202"/>
        <property type="gene ID" value="ERS852478_01983"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2873">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018826">
        <property type="term" value="F:methionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO15202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="413" mass="45044" checksum="9D22B03B2ED4681E" modified="2016-09-07" version="1">MLMEFQTKLLHGKAVDNYANGSTVPPVSLANAFAYESSEQLEKVFQNRAPGFAYTRIANPTVDAFERRVNELEGGIGGVACSSGMSAVTLSLLNILQAGDEVIAGSALFGGTLDLLHDLEAFGIKVHFIPRVEKALIEPFLTDKTRAVFGEIVGNPALNVMDVRETADFLHGKGVPLIVDSTTSTPYLLNPIQYGADVVVHSTSKYINGSGDAISGIIIDSGNFSWSPERYPGMKEYKKYGKFAYLVKLRNGIWRNMGGCLAPMNAYLNIIGMETLGLRMERVCNNAFRLAQALEKLEGVSVNYPLLESSPYHELAEKQLSGKGGAILTIRAGSKERAYKLINHLKYVKIATNIGDVRTLVIHPASTIYIHSTPEAMEEAGVYDDTIRISVGIEDIKDLIKDFTEAVESLGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CYQ8</accession>
    <name>A0A174CYQ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02368</name>
        <name evidence="1" type="ORF">ERS852478_02076</name>
        <name evidence="3" type="ORF">GT712_14185</name>
        <name evidence="2" type="ORF">GT728_13885</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">BIOML-A1</strain>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO18187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000035">
        <property type="protein sequence ID" value="MZL34264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000030">
        <property type="protein sequence ID" value="MZS90187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053835.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO18187">
        <property type="protein sequence ID" value="CUO18187"/>
        <property type="gene ID" value="ERS852478_02076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO18187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL34264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="88" mass="10001" checksum="D474DA540A3AC4F6" modified="2016-09-07" version="1">MTTVERLEELKTVDIKEIERDSLPKYKDLISELDSRKSNKMEVLLNHSDNPYVYEDMGYVVKSVFNAAASLSYIDCTKQLVAKKAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D1L8</accession>
    <name>A0A174D1L8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">D-alanyl-lipoteichoic acid biosynthesis protein DltB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dltB_1</name>
        <name evidence="11" type="ORF">ERS852478_02089</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200545.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19177">
        <property type="protein sequence ID" value="CUO19177"/>
        <property type="gene ID" value="ERS852478_02089"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO19177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="503" mass="57384" checksum="46CA6A5FAEB399FA" modified="2016-09-07" version="1">MSLVSNLFLLFVAVSVLVYYIVPHKFQWLVLLCFSYIYYLAGGVRYVGFILFSTLVTWGIALAVEKAEAGGSHKSARNFLVLGLILNFGMLGVIKYTNFMIENLNALFHMNLRGMEILLPLGISFYTFQSSGYLLDVYWKRCDAERNPVKYALFVSFFPQILQGPIGRYSRLAHQLYEPHKFEGKNIIRGFERILWGFFKKMILADWAAVFVDAIFDNPDQYSGLAIFGVLFYTVQLYADFSGGMDVVIGIASMFGIELDENFKRPFFSISITDFWHRWHITLGTWMKDYVFYPVTLSKWMGKFGKWGKKVFGKKTGRTLPICLANLIVFFVVGVWHGAAWKYIVYGMYNGIIIAFSGLMAEHYRNWKKKFNITGKENWYHVFMIIRTFILVNISWFFDRADTVGQAFHMMKLSVTKFAPSQLLLIPAGKEGTAFTPYALAILAAGCIILFIVSVLQERGMKIRESLAGLSLPITVAIYFCLLASIGFFGSTAVARGFIYAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D9X6</accession>
    <name>A0A174D9X6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">30S ribosomal protein S1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">S1 RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpsA_1</name>
        <name evidence="5" type="synonym">rps1_1</name>
        <name evidence="5" type="ORF">BWLFYP14_02857</name>
        <name evidence="2" type="ORF">ERS852478_02196</name>
        <name evidence="3" type="ORF">ERS852523_01702</name>
        <name evidence="4" type="ORF">GT728_11180</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000015">
        <property type="protein sequence ID" value="CUP46562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000025">
        <property type="protein sequence ID" value="MZL33744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380403.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000025.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000021_gene1704"/>
    <dbReference type="EnsemblBacteria" id="CUO22542">
        <property type="protein sequence ID" value="CUO22542"/>
        <property type="gene ID" value="ERS852478_02196"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP46562">
        <property type="protein sequence ID" value="CUP46562"/>
        <property type="gene ID" value="ERS852523_01702"/>
    </dbReference>
    <dbReference type="GeneID" id="66493388"/>
    <dbReference type="eggNOG" id="COG0539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="109"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="196"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO22542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP46562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="302" mass="33083" checksum="EF046B939940B16C" modified="2016-09-07" version="1">MAESMKDYETELEASFKKIEEGDILTGTVISVDEKEVVVDLKYYAEGIIPAEDYSREPGFSLKEQVNVGDEVSATVVSKDDGNGNILLSRTEAADVLAWDKLKELKDSKEVIDVVVKGIVNGGVIAYVEGVRGFIPASKLALNYVEDTNEYLNKPIQVQVFDIDKEKGRLILSAKEILREKAEEERKTKISNVQVGLVTEGVVESLQPYGAFVDLGNGLSGLVHISQICEKRIKKPSEVLTVGDKVKVKVTAVKDGKLSLSIKEATDMMAKEIEEEVIELPDSKEEASTSLGALFANIKLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DG16</accession>
    <name>A0A174DG16_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200631.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24434">
        <property type="protein sequence ID" value="CUO24434"/>
        <property type="gene ID" value="ERS852478_02242"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024760">
        <property type="entry name" value="HTH_dom_conjug_TS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12645">
        <property type="entry name" value="HTH_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_16" evidence="1">
        <location>
            <begin position="10"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO24434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="81" mass="9483" checksum="B5C486BB7BB0140C" modified="2016-09-07" version="1">MKRTFKKPSFYLISSATDGDAKAIEKILAFYDPYISKCCLRPFYDEYGNVYIAVDMELKGRIREALIKMMLDFDIPLEIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DH31</accession>
    <name>A0A174DH31_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA segregation ATPase FtsK/SpoIIIE and related proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005428608.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24902">
        <property type="protein sequence ID" value="CUO24902"/>
        <property type="gene ID" value="ERS852478_02258"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="3">
        <location>
            <begin position="214"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="231"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO24902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="455" mass="52624" checksum="657C11C081668CCE" modified="2016-09-07" version="1">MRKIWNKGHRIRASDKHLVYHFSIGMLLVVFVAVLLLLNIKQLMRTDWEHFSLLENGLTLSPYNFITILIATGVCALVAFLYYRFCYDSFKKLLHRQKLARMVLENKWYEADTVQDSGFFTDRQSRSREKIVWFPKIYYQMEKGLLHIRCEITLGKYQDQLLRLEDKLESGLYCELTDKTLHDGYIEYTLLYDMIANRITIDEVRAENGSLRLMKNLVWEYDALPHALIAGGTGGGKTYFLLTLIEALLHTNAVLYVLDPKNADLADLGTVMGNVYHTKEEMIDCVNAFYEGMVQRSEEMKRHPNYKTGENYAYLGLPPCFLIFDEYVAFFEMLGTKESVSLLSQLKKIVMLGRQAGYFLIVACQRPDAKYFSDGIRDNFNFRVGLGRISELGYGMLFGSDVKKQFFQKRIKGRGYCDVGTSVISEFYTPLVPKGHDFLQEIGRLEEKRTASNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DIG1</accession>
    <name>A0A174DIG1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacterial protein of uncharacterized function (DUF961)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005428605.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24987">
        <property type="protein sequence ID" value="CUO24987"/>
        <property type="gene ID" value="ERS852478_02261"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZBK5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010365">
        <property type="entry name" value="DUF961"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038620">
        <property type="entry name" value="YdcP-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06125">
        <property type="entry name" value="DUF961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO24987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="127" mass="14140" checksum="980099BC7B92D2B8" modified="2016-09-07" version="1">MRLSNGFVIDKEKTFGELKFTAVRDVFLQNEDGTPSTQLKKRIYDLKCSLHGGIIPVSVPPEVPLREFPYNAVVELVNPVADTVSRKTYTGADVDWYVKAENIVLKNKGNQNAGSPQNHTPQGQPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DYX1</accession>
    <name>A0A174DYX1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Threonine-phosphate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.81</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobD_2</name>
        <name evidence="3" type="ORF">ERS852478_02425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.81" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200751.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30802">
        <property type="protein sequence ID" value="CUO30802"/>
        <property type="gene ID" value="ERS852478_02425"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="15"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO30802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="347" mass="39495" checksum="A6353CD5735D315C" modified="2016-09-07" version="1">MTKHIHGGDVYKYDHCLDFSANCNPLGTPQSVKQAIIDSVEDLSDYPRVGCGPLKEAITDYEYTKKEYLICGNGAADLIFSLSRALNPKKALLPAPTFAEYEQALVSVGCEISRYYLKEENDFCIQKDYPDVLKREKPDIIFLCNPNNPTGITIPQDLLEEILETCAMQGIFMVVDECFLDFVKDPEKYTLKGKLEKYPGLFILKAFTKRYAIPGVRLGYGFCSDRKVLDRMEAVTQPWNVSTMAQQAGMAALKESEYVEAGRQIIFRESAWMKEKMRQVGLTVYPSEANYIFFYGPEDLFERCVAKGILIRDCSNYLGLKKGYYRVAVKLHEQNEKLIEVLEEVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E2R4</accession>
    <name>A0A174E2R4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 13">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="8">GluTR</shortName>
            <ecNumber evidence="4 8 13">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 17" type="primary">hemA</name>
        <name evidence="18" type="ORF">BWLFYP14_00126</name>
        <name evidence="17" type="ORF">ERS852478_02411</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 19">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 13">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 13">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="4 8 13"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019161306.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30340">
        <property type="protein sequence ID" value="CUO30340"/>
        <property type="gene ID" value="ERS852478_02411"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GlutR_N" evidence="16">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="15">
        <location>
            <begin position="173"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="GlutR_dimer" evidence="14">
        <location>
            <begin position="312"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="112"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <begin position="187"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="8 12">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000445-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CUO30340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="VUX66573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="409" mass="45797" checksum="3AD4558C8DF7D00B" modified="2016-09-07" version="1">MSISMIGIDHNMAPVDIRAKFAFTKKNAGEAMEKIKNQNGIYGCVILSTCNRLEVWASVDDEVDVCLYDCLCRIKGITEDSYRQYFVERKDQEAVEHLFYLTSGLKSQIIGEDQILTQVKDALNLARENFAADGVLEVLFRMAATAGKRIKTEVPFSHGNPSVIHQAIGFLAEKGYSLRDKTCMVIGNGEMGKVAAQALQEAGADVTVTIRQYRSGVVNIPLGCKRINYGDRMEYMPQCDLVVSATASPNFTLKEELFQGIRTKDDLILIDLAVPRDIEPSVGKIQGVTLYDMDSFRIEEVPAELQENLEAAGAIVREQMDEFFQWLDGRDLIPRIQDIKDEAVNDLNLRIAKILKKTPMEEDDRQNLVHAVDTAAGKVVNKLIFGLRDSLNQEIFLECVAGLEKIYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EA28</accession>
    <name>A0A174EA28_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FtsX-like permease family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="9">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">macB_5</name>
        <name evidence="13" type="synonym">macB_1</name>
        <name evidence="10" type="synonym">macB_6</name>
        <name evidence="13" type="ORF">BWLFYP14_00503</name>
        <name evidence="9" type="ORF">ERS852478_02508</name>
        <name evidence="10" type="ORF">ERS852523_03381</name>
        <name evidence="12" type="ORF">GT712_02315</name>
        <name evidence="11" type="ORF">GT728_13270</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000048">
        <property type="protein sequence ID" value="CUP94821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000033">
        <property type="protein sequence ID" value="MZL34146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000004">
        <property type="protein sequence ID" value="VUX62617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703706.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000033.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000026_gene983"/>
    <dbReference type="EnsemblBacteria" id="CUO33446">
        <property type="protein sequence ID" value="CUO33446"/>
        <property type="gene ID" value="ERS852478_02508"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP94821">
        <property type="protein sequence ID" value="CUP94821"/>
        <property type="gene ID" value="ERS852523_03381"/>
    </dbReference>
    <dbReference type="GeneID" id="66495259"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="325"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO33446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP94821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL34146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS87956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX62617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="419" mass="45358" checksum="A34AD6C99D94307F" modified="2016-09-07" version="1">MLENIRLAFQGIWSHMMRSFLTMLGIIIGIASIIAIVSTIKGTSEQIKEDLIGAGSNTVKIYLYDGDNQYDAEYGNSSKTPILTDDVKEEVKDLDHVENATFYYNSTSASIYNNNNSLEGGSVYGIDVNYLATCGYIIQSGRGFVKDDYKNYNKVALIDDNAAQNLFPSQNPVGQTVEINQEPYTIVGVIRQDENYQPTINSIDEYYTYYQSIVGSVMIPDSCWPISFKFDVPQNVIVKADSTDTMSSVGNAAADVLNNLIAALNTDGNTTMKYKADNIMEQVKNMQKLSESTNNQLIWIASISLLVGGIGVMNIMLVSVTERTKEIGLKKAIGARKKTILGQFLTEASVLTSIGGIIGVITGIGLSKVVGKVTGSPTAISVPSIVIAVLFSTVIGVVFGLLPSVKAANLNPIDALRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EBI0</accession>
    <name>A0A174EBI0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Protein translocase subunit SecD</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Protein-export membrane protein SecF</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">secDF</name>
        <name evidence="9" type="synonym">secD</name>
        <name evidence="10" type="synonym">secF</name>
        <name evidence="13" type="ORF">ERS852478_02522</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200766.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33829">
        <property type="protein sequence ID" value="CUO33829"/>
        <property type="gene ID" value="ERS852478_02522"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0015450">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
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        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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    <feature type="chain" id="PRO_5008020583" description="Multifunctional fusion protein" evidence="12">
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            <end position="294"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="424"/>
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            <end position="473"/>
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        <location>
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            <end position="599"/>
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            <begin position="606"/>
            <end position="628"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="655"/>
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        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
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        <location>
            <begin position="710"/>
            <end position="735"/>
        </location>
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            <begin position="751"/>
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        </location>
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        <location>
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            <end position="774"/>
        </location>
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        <location>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
    <sequence length="802" mass="85781" checksum="52B892A8FABB1AA8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EC56</accession>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">ERS852478_02528</name>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
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            <end position="169"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUO33999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="200" mass="23233" checksum="A389C52A24F9C676" modified="2016-09-07" version="1">MMNDVYEKFLKSSEEFIFAENKPEKSDIIFVPGNGYPQMAEKAAELFKKGMADWILPSGKYSVVNGKFSGVLEKSNVYDKEYGTEWEFLRDVLIKNGVPDQKILKEDQATFTYENAIYSRQVTDHAELEIERAILCCKSYHARRCLMYYQLLYPKTEFYVVPVNADGITRENWKKNEEGIDAVTGELSRIVKQFSLMLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EPG2</accession>
    <name>A0A174EPG2_9FIRM</name>
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        <submittedName>
            <fullName evidence="3">Lipoprotein lplA</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Blautia wexlerae</name>
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
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            <end position="568"/>
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            <end position="61"/>
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    </feature>
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            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="568" mass="65284" checksum="6D6E2932E2D26257" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EQL8</accession>
    <name>A0A174EQL8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized metallophosphoesterase Cj0846</fullName>
            <ecNumber evidence="4">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
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            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="4"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000041.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUO38896"/>
        <property type="gene ID" value="ERS852478_02664"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
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        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="160"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO38896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="400" mass="45009" checksum="D4A6B05132CC9E07" modified="2016-09-07" version="1">MAAIYLAPFYLLVCVYILLRSLHWFQVLHTVFRNVWVCRGIGLVYLFVVFSILIAFMAPASGFRRFMKLLSNYWLGVLMYTLMTLGIADGLRLLLKYPLRNLGFPGRELLFSNMGTAVVGAVCAVIISTVSIYGVLSAGNIHTTKYNISVDKKAGNMKELKVVLVADFHLGYNIGCKQMEQMTEKINEQKPDLVVVAGDIFDNEYEALDDPEKLAEILRGIRSKYGVYACYGNHDIQEKILAGFTFGSKEKKESTPEMDEFLEKAGITLLRDEYVLIDDSFYLYGRPDYERPGRGIDKRKTPQEITEGMDVSLPVLVIDHEPRELQELADTGVDVDLCGHTHDGQVFPGNIVIRFFWENPCGYLKKGNMHNIVTSGVGLFGPNMRVGTKSEICDVSICFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ETP7</accession>
    <name>A0A174ETP7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="16">EIIBCA-Bgl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">bglF</name>
        <name evidence="16" type="ORF">ERS852478_02679</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO39360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200832.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39360">
        <property type="protein sequence ID" value="CUO39360"/>
        <property type="gene ID" value="ERS852478_02679"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00212">
        <property type="entry name" value="PTS_IIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036878">
        <property type="entry name" value="Glu_permease_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018113">
        <property type="entry name" value="PTrfase_EIIB_Cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001127">
        <property type="entry name" value="PTS_EIIA_1_perm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013013">
        <property type="entry name" value="PTS_EIIC_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001996">
        <property type="entry name" value="PTS_IIB_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00358">
        <property type="entry name" value="PTS_EIIA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00367">
        <property type="entry name" value="PTS_EIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02378">
        <property type="entry name" value="PTS_EIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55604">
        <property type="entry name" value="SSF55604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00826">
        <property type="entry name" value="EIIB_glc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00830">
        <property type="entry name" value="PTBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51093">
        <property type="entry name" value="PTS_EIIA_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00371">
        <property type="entry name" value="PTS_EIIA_TYPE_1_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51098">
        <property type="entry name" value="PTS_EIIB_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01035">
        <property type="entry name" value="PTS_EIIB_TYPE_1_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51103">
        <property type="entry name" value="PTS_EIIC_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIB type-1" evidence="14">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIC type-1" evidence="15">
        <location>
            <begin position="120"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="PTS EIIA type-1" evidence="13">
        <location>
            <begin position="504"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate; for EIIB activity" evidence="11">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CUO39360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="634" mass="68002" checksum="56D04F3C230D022E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EUW5</accession>
    <name>A0A174EUW5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sporulation protein YabP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580783.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40458">
        <property type="protein sequence ID" value="CUO40458"/>
        <property type="gene ID" value="ERS852478_02707"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YWW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012504">
        <property type="entry name" value="Spore_YabP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022476">
        <property type="entry name" value="Spore_YabP/YqfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038705">
        <property type="entry name" value="YabP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07873">
        <property type="entry name" value="YabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011576">
        <property type="entry name" value="YabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02892">
        <property type="entry name" value="spore_yabP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO40458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="93" mass="10796" checksum="B943D35D157A82F6" modified="2016-09-07" version="1">MEEKKILSTHSLMLENRQNGRITGVKDIKSFDEKEILLFTQAGKLVIKGEQLHVKQLDLEKGEVDLEGKVDSLTYLSKNTDNRDESLFKRMFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EXB4</accession>
    <name>A0A174EXB4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="7">TC-AMP synthase</shortName>
            <ecNumber evidence="4 7">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rimN</name>
        <name evidence="10" type="ORF">ERS852478_02716</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="4 7"/>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060249.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40670">
        <property type="protein sequence ID" value="CUO40670"/>
        <property type="gene ID" value="ERS852478_02716"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="9">
        <location>
            <begin position="15"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO40670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="350" mass="37843" checksum="1267E22AC4EA3DFB" modified="2016-09-07" version="1">MKAEVVSMTADNLDMEAIRRGGDILKQGGLVAFPTETVYGLGGDALNPQASMKIYAAKGRPSDNPLIVHIAEFDKLDSIVTEVPEKAKILAEKYWPGPLTMILPKSDLVPQETTGGLDSVAVRFPSDRIAQELIKAAGGYVAAPSANTSGRPSPTTAQHVEEDLGEAIEMIIDGGQVGIGLESTIVDFTEDVPVVLRPGYISLEMLQETLGDVRMDKGLIASDSKVRPKAPGMKYRHYAPKADLAIVEGPEEAVVKKINELAAEAKAHGEQVGIIATDETKDRYPEGLVVSIGSRKEEETIAHHLYEVLRDFDQSAVRSIYSEAFYTPRMGQAIMNRLLKAAGHKIIQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F791</accession>
    <name>A0A174F791_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">uvrC</name>
        <name evidence="10" type="ORF">ERS852478_02841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200957.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000061.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44696">
        <property type="protein sequence ID" value="CUO44696"/>
        <property type="gene ID" value="ERS852478_02841"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="8">
        <location>
            <begin position="13"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="204"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="9">
        <location>
            <begin position="271"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO44696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="620" mass="72060" checksum="D20DC6974F772790" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FB76</accession>
    <name>A0A174FB76_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA repair protein RadA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47001">
        <property type="protein sequence ID" value="CUO47001"/>
        <property type="gene ID" value="ERS852478_02919"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="34"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO47001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="329" mass="36848" checksum="2B4CFA913CF82BD2" modified="2016-09-07" version="1">MEQRNENKTELKMIKMSDVQSQTVDWLWYPFIPYGKLTIIQGDPGDGKTTLVLNIAARLSKGEGLDNDMKVTEPVNIIYQTAEDGLADTVKPRLELAEAVCERIMVIDETEKSLSMIDERLETAIKQTGARVLILDPIQAYLGGTMDMNRANEARDMTKRLSLLAEKYKCAILLIGHMNKAGGNKAAYRGMGSIDFFAVARSVLLVGRIEGEPDLRAVVQIKNNLAAFGHSKAFRLTETGFEWIGDYEITADEVLGGIAPKVNKLEQAKKMLRELAETSTSVQSSEIFDMAEDLNISKRTLENAKKELEIKARRIGNSWYWDLDKVKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FBW1</accession>
    <name>A0A174FBW1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">ERS852478_02883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200984.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45830">
        <property type="protein sequence ID" value="CUO45830"/>
        <property type="gene ID" value="ERS852478_02883"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO45830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="461" mass="50731" checksum="431E6DE3B19C2A2D" modified="2016-09-07" version="1">MKKENNSAHNHNRGSFSGRIGYVLAVAGSAVGLGNIWRFPYLAAKYGGGIFLLIYILLTASFGYVLIMSETALGRMTRKSPVGAFEHFGKTKSFKIGGWLNAVIPMLIVPYYSTIGGWVIKYLVEYFKGNVQAVAEDGYFGNFISDSWQVELWFLVFAALVFIIILGGVQNGVERMSKIMMPVLVVLAVVVTIYSVTRPGAVEGVKYFLIPNVKNFSWMTVVAAMGQMFYSLSIAMGILYTYGSYVRKDMDIERSTTQVEIFDTGIAILAGLMIIPAVFAFSGGNPETLQAGPSLMFITLPKVFASMGFGTATGIVFFILVLLAALTSAVSLMETSVSTFMDELHWSRKKCCGLMVVIMIVLGTASSMGYGLLDFIRIFGMNFLDFFDFMTNSVMMPLAALATCILILRVVGIDGMEKEIEQSSPFRRKKLYRVFIKYFAPICLIIILLSSIANVLGIISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FCG7</accession>
    <name>A0A174FCG7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">rplJ</name>
        <name evidence="7" type="ORF">ERS852478_02937</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201013.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47481">
        <property type="protein sequence ID" value="CUO47481"/>
        <property type="gene ID" value="ERS852478_02937"/>
    </dbReference>
    <dbReference type="GeneID" id="66494700"/>
    <dbReference type="eggNOG" id="COG0244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO47481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="167" mass="18041" checksum="80BA6BCB66EF9C69" modified="2016-09-07" version="1">MAKVELKQPIVDEIINNVKDAESVVLVNYSGLTVEQDTALRKELREAGVVYKVYKNTMMHRAFEGTQCEELIQHLHGTNAIAISATDATAPARILDKFAKKAPALELIAGIVEGNYNDQAGIQALAGIPSREELLGKLLGSIQSPITNFARVLNQIAEKNGSEAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FK65</accession>
    <name>A0A174FK65_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="13">D-alanyl-D-alanine carboxypeptidase dacB</fullName>
            <ecNumber evidence="13">3.4.16.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dacB_6</name>
        <name evidence="13" type="ORF">ERS852478_02975</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="13"/>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201042.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48860">
        <property type="protein sequence ID" value="CUO48860"/>
        <property type="gene ID" value="ERS852478_02975"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018337">
        <property type="entry name" value="Cell_wall/Cho-bd_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01473">
        <property type="entry name" value="Choline_bind_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51170">
        <property type="entry name" value="CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021758" evidence="11">
        <location>
            <begin position="34"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="Cell wall-binding" evidence="9">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="12">
        <location>
            <begin position="176"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO48860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="419" mass="46776" checksum="B8DCEEE697BC6F54" modified="2016-09-07" version="1">MKRKRNHSLRSSVFIFLAALFLLFTCSVSTIYASTLQKPDIAASGKFVKNGDYWIYRYDDKTIAKNVFLKIDKKTYYFNKLGHRWCSWHTIKGKNYYFGTRSQGYLIKNSLIKYKGNYYYVGKDGAMVTGWYTDKSGKKYYFGKDGKAVTGKHKIKGTYYYFNQNGTITHTGLNYSLSSDCALLMNADTGQIIYGKNENVAHANASTTKIMTCILALENCKLNEKVKFSPYAASIEPSKLYANAGEIFYLKDLLYSLMLPSHNDTAVAIAEHVSGSTAKFVKLMNKKAAEIGCTNTHFATPNGLDAGYNHYTTASDLAKIAQYAIKKPMFRKLVSTGYYSFSNLNTGRSYSIGTTNALLGNVPGVQGMKTGYTNKAGYCFVGLSYSARGNTYISVVLGADSSSARWQDSRTLLTYAYNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FMC7</accession>
    <name>A0A174FMC7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit beta</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">atpD_2</name>
        <name evidence="10 14" type="synonym">atpD</name>
        <name evidence="16" type="ORF">BWLFYP14_03553</name>
        <name evidence="12" type="ORF">ERS852478_03038</name>
        <name evidence="13" type="ORF">ERS852523_01446</name>
        <name evidence="15" type="ORF">GT712_01570</name>
        <name evidence="14" type="ORF">GT728_10255</name>
    </gene>
    <organism evidence="12 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 17">2789STDY5834863</strain>
            <strain evidence="13 18">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="14 20 21" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 21">BIOML-A1</strain>
            <strain evidence="15 20">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="16 19" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP38562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000021">
        <property type="protein sequence ID" value="MZL33571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704959.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000021.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000037_gene3255"/>
    <dbReference type="EnsemblBacteria" id="CUO50891">
        <property type="protein sequence ID" value="CUO50891"/>
        <property type="gene ID" value="ERS852478_03038"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP38562">
        <property type="protein sequence ID" value="CUP38562"/>
        <property type="gene ID" value="ERS852523_01446"/>
    </dbReference>
    <dbReference type="GeneID" id="66495476"/>
    <dbReference type="eggNOG" id="COG0055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="145"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="153"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO50891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUP38562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZL33571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZS87813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VUX67278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="464" mass="50681" checksum="244F41C5FB2745AD" modified="2016-09-07" version="1">MSEKHIGEVVQVIGPVLDIRFAHDELPPLLNAIEIDNDGAKLVAEVAQQVGDDVVRCIAMNSTDGLVRGAKALDTGGPISVPVGEECLGRVFNLLGDPVDNLPAPEAKERWSIHRQAPSYEEQMPATEILETGIKVVDLICPYAKGGKIGLFGGAGVGKTVLIMELIHNVATAHGGLSVFTGVGERTREGNDLYNEMKESGVIDKTALVYGQMNEPPGARMRVGLSGLTMAEYFRDEKNQDVLLFIDNIFRFTQAGSEVSALLGRMPSAVGYQPTLATEMGNLQERITSTRKGSITSVQAVYVPADDLTDPAPATTFSHLDATTVLSREISSQGIYPAVDPLDSTSRILSPEIVGTEHYEIARSVQRVLQRYKELQDIIAIMGMDELSEEDKRTVSRARKVQRFLSQSFSVAEQFTGMPGKYVPLKETLRGFRMILNGECDDIPESYFLFVGTIDEVFEKAKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FNY7</accession>
    <name>A0A174FNY7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Germination protein, Ger(X)C family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_03062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GerABKC lipoprotein family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Spore germination protein (SGP) (TC 2.A.3.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379932.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51944">
        <property type="protein sequence ID" value="CUO51944"/>
        <property type="gene ID" value="ERS852478_03062"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009847">
        <property type="term" value="P:spore germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004761">
        <property type="entry name" value="Spore_GerAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008844">
        <property type="entry name" value="Spore_GerAC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35789">
        <property type="entry name" value="PTHR35789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03845">
        <property type="entry name" value="Spore_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0309">Germination</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO51944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="561" mass="62005" checksum="13382858A069E884" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FWK5</accession>
    <name>A0A174FWK5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201156.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53216">
        <property type="protein sequence ID" value="CUO53216"/>
        <property type="gene ID" value="ERS852478_03099"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032R4X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025464">
        <property type="entry name" value="DUF4315"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14193">
        <property type="entry name" value="DUF4315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO53216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="89" mass="10052" checksum="2A9B18CCD6A7EE9B" modified="2016-09-07" version="1">MANNKIDRINKEIAKTREKITEYQNKLKGLEAQKTEAENLEIVQLVRAMRMTPQELNAMLKGDTIPGMTAAPATEAADYEEQEDNADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FYG3</accession>
    <name>A0A174FYG3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF3847)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005335898.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPF010000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53590">
        <property type="protein sequence ID" value="CUO53590"/>
        <property type="gene ID" value="ERS852478_03112"/>
    </dbReference>
    <dbReference type="GeneID" id="43514872"/>
    <dbReference type="GeneID" id="64114873"/>
    <dbReference type="GeneID" id="66495702"/>
    <dbReference type="eggNOG" id="ENOG5031UPX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024215">
        <property type="entry name" value="DUF3847"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12958">
        <property type="entry name" value="DUF3847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO53590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="98" mass="11662" checksum="3987F23CA8F8B6B0" modified="2016-09-07" version="1">MPDTSKLGKLNRELEKSEKKLRKAINDEKALQHQLKQLTRKERTHRLCTRGGMLESFLQEPERLTDDDVMLLLKLIFHRQDTQDILKKLLEREKPETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G2J4</accession>
    <name>A0A174G2J4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH dehydrogenase subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_03186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO56201">
        <property type="protein sequence ID" value="CUO56201"/>
        <property type="gene ID" value="ERS852478_03186"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="319"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO56201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="380" mass="42199" checksum="BB709BD8392FE7F9" modified="2016-09-07" version="1">MNLVKSKVVLLPCREYDEEKIYMLLKQGLDFLGGVETLIPKDAKILLKPNLLKKAEVEKAVITHPVVVGAFAGILRESRYENIVLADSCGHGTTQAVIRGTGMDTYLEKYHIPAVDYSEGVKTAYPQGAQAKEFILPKELLEQDCVISLSKMKTHALERITGAVKNSYGFIYGFHKAKGHTQYPSADSFARMLIDLNKCVAPKLYVMDGIVAMEGNGPGSGDPVPMNVLLMSTDPVALDSVFSRLVYLKPEMVPTNYHGEKMGLGTWKEEEITLLTPDGEISMAEAVKKYGNPAFNVDRTEVRKNIWTRMAGALNIFQKKPYIEADKCVRCGICVQSCPVPGKAVDFRKGKGKPPVYDYRKCIRCFCCQEMCPKKAIKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G8S5</accession>
    <name>A0A174G8S5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-HC2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_03487</name>
        <name evidence="3" type="ORF">ERS852478_03270</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO58832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381005.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000064.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58832">
        <property type="protein sequence ID" value="CUO58832"/>
        <property type="gene ID" value="ERS852478_03270"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030J7T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO58832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX67212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="217" mass="25564" checksum="38FCF89C946ADF79" modified="2016-09-07" version="1">MEKINCNVIQDILPLYIDDVVSDDTKELVEEHLQNCEICQRVYHETKTDLENDMKVSVQTKESSNEANDLKNFRKFLKKRKIKTILLSIAATIVCFVAVFMFMNKHVTYISYKDAGITIIEDNKDEVTYRTNIKGNYRWRTSLDRETGVMTIHFEQSLWEKYVSCIFYPYDHIHDILKKDEIKEVYVDKDGTTTTIWEAPEEEQKAYLSEEHTEPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GD57</accession>
    <name>A0A174GD57_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase involved in DNA repair</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smc_4</name>
        <name evidence="3" type="ORF">BWLFYP14_03484</name>
        <name evidence="2" type="ORF">ERS852478_03267</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO58759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
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                <person name="Venkatesh S."/>
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        <source>
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</entry>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03530</name>
        <name evidence="2" type="ORF">ERS852523_01595</name>
        <name evidence="3" type="ORF">GT712_09180</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000014">
        <property type="protein sequence ID" value="CUP43237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059878.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000052.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67252">
        <property type="protein sequence ID" value="CUO67252"/>
        <property type="gene ID" value="ERS852478_03530"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP43237">
        <property type="protein sequence ID" value="CUP43237"/>
        <property type="gene ID" value="ERS852523_01595"/>
    </dbReference>
    <dbReference type="GeneID" id="60301296"/>
    <dbReference type="GeneID" id="66494988"/>
    <dbReference type="eggNOG" id="ENOG5032DC9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO67252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP43237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS89241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="63" mass="7151" checksum="2AB0DABF282D8AFB" modified="2016-09-07" version="1">MATSSITHNFVISNPNSVKHFIAAIDEADRDRTPKQTLPGRQLTNPQEILALMSKRKKQTLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GYE9</accession>
    <name>A0A174GYE9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-keto-3-deoxy-galactonokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058929.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66237">
        <property type="protein sequence ID" value="CUO66237"/>
        <property type="gene ID" value="ERS852478_03494"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008671">
        <property type="term" value="F:2-dehydro-3-deoxygalactonokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007729">
        <property type="entry name" value="DGOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042257">
        <property type="entry name" value="DGOK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042258">
        <property type="entry name" value="DGOK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05035">
        <property type="entry name" value="DGOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO66237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="335" mass="36558" checksum="CDEB9BA916536FCC" modified="2016-09-07" version="1">MDTYTITIDGGTTNTRCILWNSSRQRIDEQKREVGVRNTAIDGNNSKLKNAVKECLEQLLEDHSLTYDNINHIIASGMITSDVGIVVVPHLTAPADLEQIARSTVAIRLPEICPIPIHFIPGIKNSCSNISLENYEAMDIMRGEEVESLAIIDKYHNGSPMILVLPGSHNKFVAVNADKEITGCLTSISGELLSAIINDTIIAKSVNRSFVTADQYDRKWLLLGYNTAKETGLGRACFSGRILGLFCNAEPSKISNYILGAALQGDIQAIRNSSALCVTDDTQFVVCGKDPFKQALVDIFTEEKLSNQITIFEPEAGFSASALGAYLVAEKCKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZW8</accession>
    <name>A0A174GZW8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PD-(D/E)XK nuclease family transposase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Rpn family recombination-promoting nuclease/putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_03471</name>
        <name evidence="1" type="ORF">ERS852478_03499</name>
        <name evidence="2" type="ORF">GT712_15640</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000038">
        <property type="protein sequence ID" value="MZS90462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000081">
        <property type="protein sequence ID" value="VUX67196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060744.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000167.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66370">
        <property type="protein sequence ID" value="CUO66370"/>
        <property type="gene ID" value="ERS852478_03499"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO66370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS90462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX67196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="273" mass="31996" checksum="D82761B284153FB1" modified="2016-09-07" version="1">MNEEERFDFEQKHEEDLQRLRGFRLLDDDFMSKVFEDKNCVEFLLQIILKRDDLKVTSVSSQYVIKNLQGRSVRLDILAVDRQNQVYNIEIQRDDKGAGVKRARYNSSLIDANVTEPGEQYQNLNETYVVFITENDVLGENIPIYHVDRIVRETGKMFNDQSHIIYVNSQIKDETALGKLMHDFTCTNAKDMYYEVLADRVHYFKEDEKGVAIMCKAMEDMRNEAAREAEKMKAIRMARLMIEDGKLNYEDIAMYTELTLEEVEKIALEKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H5R5</accession>
    <name>A0A174H5R5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060681.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68339">
        <property type="protein sequence ID" value="CUO68339"/>
        <property type="gene ID" value="ERS852478_03569"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO68339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="317" mass="37415" checksum="9A90EB3D97709DDE" modified="2016-09-07" version="1">MRNLIDLKSPNVNLVLSSLLKDRTTGKNIIFATEISDDIHFTTNITKDLLLKDNRIDIRPRVSKSMEEQVKRTRKKAEVFTPSWICNKMNNHCDTEFFGRENVFNIEDGQKWISNDEKIEFPAGKTWKDYVESKRLEITCGEAPYLVSRYDTVTGEIIPIHQRIGLLDRKLRVINENVTTYKTWIQWVYRAFESVYGYEYQGDNLLIARINLLETFCEYMRDRWQEEPNKTSLNRIADIISWNLWQMDGIYGVIPYEGAVYVQEEEEESHQMTLFEIYGIAGEAEPEPEAELPETIDCKIYDWDENKIITYKSMREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HAQ5</accession>
    <name>A0A174HAQ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphatase YtkD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71331">
        <property type="protein sequence ID" value="CUO71331"/>
        <property type="gene ID" value="ERS852478_03664"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="106"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="251" mass="29616" checksum="BDC3121DF16680B5" modified="2016-09-07" version="1">MSRKNHKMIDGRLLQTNKKYSQLKMKQKEKIAEWMFQATRDYYMKKCTFPSDKHLEEVVDSVYEKIEDAEIWIPYGEVFKHYKSKRSDINKRVRKSLNEKEESRIEKVCFMNMCMIQDHKGNVLALDKVNDSYTGTTFPGGHVEANEIFQKSMIREVWEETGLTVEAPKLGGLYHWHKSGVHYVITLYKADKFTGELKSYEEGRVYWIPLEELKTKELATGMEHVLRILESEKVDECYMHLEADGYVGDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HDH1</accession>
    <name>A0A174HDH1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201481.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71386">
        <property type="protein sequence ID" value="CUO71386"/>
        <property type="gene ID" value="ERS852478_03667"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021205">
        <property type="entry name" value="Lantibiotic_perm_SpaE/MutE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03732">
        <property type="entry name" value="lanti_perm_MutE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="248" mass="27620" checksum="D7113EE1CA6DB1B6" modified="2016-09-07" version="1">MEMAYIQAENLKHKRTFTKTLIVLAPFVTALMNFFAPLWFQLNSYNWWYILLYPGFLTLTCALIEQRDNGKLKYRAVASLPVSQNKVWKAKIGVAGIYSCVGNFIFLALNLLGGFAILVINEIPLTIGIWQAAAGTACIVIASLWEVPLCLWLSKKVGIFVTVILNAGLGSVLGIFTATTSLWMICPYSWVPHLMISVLGIFPNGEPVADQSTAMAFWMIILVLVISLAWFAALSFLTARWFEKKEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HFL0</accession>
    <name>A0A174HFL0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="3">SDR family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fabG_4</name>
        <name evidence="2" type="ORF">ERS852478_03749</name>
        <name evidence="4" type="ORF">GT712_18775</name>
        <name evidence="3" type="ORF">GT728_19145</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000046">
        <property type="protein sequence ID" value="CUO73673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000080">
        <property type="protein sequence ID" value="MZL35231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000063">
        <property type="protein sequence ID" value="MZS91026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059818.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000080.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73673">
        <property type="protein sequence ID" value="CUO73673"/>
        <property type="gene ID" value="ERS852478_03749"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO73673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL35231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS91026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="216" mass="24012" checksum="42AF00A82C27ED5E" modified="2016-09-07" version="1">MKVLITGTASGIGKGCAEFFLKENHEVYGFDKNISSIQHPKYTHFCLDIRDKSSYPEIGQVDILINNAGVQNGDDIDVNLKGTISVTEHYGIHPNIYSVIMIGSASGHTGSEFPEYAASKGGVLAYTKNVAMRIAPYQATCNSLDFGGVMTELNRPVMEDEKLWDQIMELTPLKRWMSVEEAAEWIYFMAVKNRFCTGQNILIDGLEAGNCNFIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HN08</accession>
    <name>A0A174HN08_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM mobile pair protein B</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Radical SAM superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_03829</name>
        <name evidence="8" type="ORF">GT712_15330</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000055">
        <property type="protein sequence ID" value="CUO76294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000037">
        <property type="protein sequence ID" value="MZS90403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704236.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000059.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76294">
        <property type="protein sequence ID" value="CUO76294"/>
        <property type="gene ID" value="ERS852478_03829"/>
    </dbReference>
    <dbReference type="GeneID" id="66494471"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031012">
        <property type="entry name" value="rSAM_mob_pairB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04470">
        <property type="entry name" value="rSAM_mob_pairB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="23"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO76294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS90403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="302" mass="34695" checksum="FB77F958FDDFC742" modified="2016-09-07" version="1">MEEVINGILIREVETKNIMTKSSLPVGGYSVNPYVGCTHACKYCYASFMKRFTGHKEEWGTFLDVKHWPEIKNPKKYVGQRVVIGSVTDGYNPQEEQFGNTRKLLEQLIGSDADILICTKSDLVVRDIDLLKKLGCVTVSWSINTLDENFKNDMDSASSIEHRIAAMKQVYEAGIRTVCFVSPVFPGITNFEAIFERVKDQCDLFWLENLNLRGGFKKTIMDYIAGKYPDLVPLYDEIYNKHNRSYFEALEVKAEKMAKKYDCAFVDNEMPYGRVPQGHPVIVDYFYHEEIRGTENTGKRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HNV7</accession>
    <name>A0A174HNV7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, Acidobacterial, PadR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75901">
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        <property type="gene ID" value="ERS852478_03817"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="23"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO75901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="107" mass="11603" checksum="A0DBCF03D3A04957" modified="2016-09-07" version="1">MRDNAKGGALTEVTFFILLSLYTPKHGYAVMQFIEDNTKGRLTLGAGTLYGALNSLQEKGWIAPFGDSAGRKKEYLITTQGKEIAEKELIRLNELVGVANEIIGGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K727</accession>
    <name>A0A174K727_9FIRM</name>
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        <submittedName>
            <fullName evidence="8">N utilization substance protein B homolog</fullName>
        </submittedName>
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        <name evidence="9" type="ORF">BWLFYP14_03072</name>
        <name evidence="7" type="ORF">ERS852478_01162</name>
        <name evidence="8" type="ORF">ERS852523_00483</name>
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        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
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            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
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    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
            <strain evidence="8 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="CUN82301">
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        <property type="gene ID" value="ERS852478_01162"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07872">
        <property type="protein sequence ID" value="CUP07872"/>
        <property type="gene ID" value="ERS852523_00483"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
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        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="12"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN82301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP07872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="116" mass="13199" checksum="5770C1CBBDE89FA9" modified="2016-09-07" version="1">MSEQLSLYFDTLEELSEKDQEYMSRKYRHVLEKLDEIDALLNETSNGWKTKRMSRVDLTALRLAVYELKYDKDVPTGVAINEAVELAKRFGGETSGSFVNGILGKIANSESEEKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LRG1</accession>
    <name>A0A174LRG1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01445</name>
        <name evidence="3" type="ORF">ERS852523_01026</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Clostridia</taxon>
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    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94260.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94260">
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        <property type="gene ID" value="ERS852478_01445"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP25197">
        <property type="protein sequence ID" value="CUP25197"/>
        <property type="gene ID" value="ERS852523_01026"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN94260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP25197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="74" mass="8325" checksum="6FC4D2596BF439B9" modified="2016-09-07" version="1">MAETKKTNAPEETKEVLPAEKETEYGVDELIAARDQLFSCPDCAMVALKLSKKKSMTVSEAEKLVEEFMKKEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LXK7</accession>
    <name>A0A174LXK7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03417</name>
        <name evidence="2" type="ORF">ERS852523_01081</name>
        <name evidence="3" type="ORF">GT728_07805</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
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            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26698">
        <property type="protein sequence ID" value="CUP26698"/>
        <property type="gene ID" value="ERS852523_01081"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032KAG">
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO63638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP26698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="90" mass="9856" checksum="83183ED04F8D4FFC" modified="2016-09-07" version="1">MNDDWRNNPKLAGMDRSKLDMLQNLASQGSSKGANEMLPFLMSAAAQGKKGGLKFNADEISAIIEVLKMGKSPAEAQKLDKVVNLMKMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LZY7</accession>
    <name>A0A174LZY7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SMC-Scp complex subunit ScpB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Segregation and condensation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">scpB</name>
        <name evidence="8" type="ORF">BWLFYP14_02950</name>
        <name evidence="4" type="ORF">ERS852478_03403</name>
        <name evidence="5" type="ORF">ERS852523_01095</name>
        <name evidence="7" type="ORF">GT712_13920</name>
        <name evidence="6" type="ORF">GT728_07740</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">2789STDY5834863</strain>
            <strain evidence="5 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 13">BIOML-A1</strain>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP27059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000014">
        <property type="protein sequence ID" value="MZL33097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000029">
        <property type="protein sequence ID" value="MZS90141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000072">
        <property type="protein sequence ID" value="VUX66674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704505.1">
        <property type="nucleotide sequence ID" value="NZ_JADPFJ010000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1044"/>
    <dbReference type="EnsemblBacteria" id="CUO63315">
        <property type="protein sequence ID" value="CUO63315"/>
        <property type="gene ID" value="ERS852478_03403"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP27059">
        <property type="protein sequence ID" value="CUP27059"/>
        <property type="gene ID" value="ERS852523_01095"/>
    </dbReference>
    <dbReference type="GeneID" id="66494213"/>
    <dbReference type="eggNOG" id="COG1386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO63315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP27059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL33097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS90141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="189" mass="21492" checksum="008AA7907F284D19" modified="2016-09-07" version="1">MKIKETEAAIEAILFAMGGSVELPRIARAIGVDEKTTGRIIRNMMDRYQEENRGIQIIELENSFQMCTKKEYYQYLINIALHPQKPALSDVMLETLSIIAYKQPVTKAEIEKIRGVKCDHAINKLVEYSLVRELGRLDAPGRPILLGTTEEFLRCFGVQDLESLPVPDPVQIEDFKAEAEEEIQLKLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NMD9</accession>
    <name>A0A174NMD9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="2">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Alpha-IPM isomerase</fullName>
            <shortName evidence="2">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DmdB_1</name>
        <name evidence="4" type="synonym">DmdB_2</name>
        <name evidence="2 6" type="synonym">leuD</name>
        <name evidence="8" type="ORF">BWLFYP14_02805</name>
        <name evidence="4" type="ORF">ERS852478_02103</name>
        <name evidence="5" type="ORF">ERS852523_01748</name>
        <name evidence="7" type="ORF">GT712_17090</name>
        <name evidence="6" type="ORF">GT728_16290</name>
    </gene>
    <organism evidence="5 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">2789STDY5834863</strain>
            <strain evidence="5 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 12 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 13">BIOML-A1</strain>
            <strain evidence="7 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LeuD family. LeuD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000015">
        <property type="protein sequence ID" value="CUP47808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000049">
        <property type="protein sequence ID" value="MZL34709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000048">
        <property type="protein sequence ID" value="MZS90726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708263.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000130_gene185"/>
    <dbReference type="EnsemblBacteria" id="CUO19651">
        <property type="protein sequence ID" value="CUO19651"/>
        <property type="gene ID" value="ERS852478_02103"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP47808">
        <property type="protein sequence ID" value="CUP47808"/>
        <property type="gene ID" value="ERS852523_01748"/>
    </dbReference>
    <dbReference type="GeneID" id="66494807"/>
    <dbReference type="eggNOG" id="COG0066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01032">
        <property type="entry name" value="LeuD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011827">
        <property type="entry name" value="LeuD_type2/HacB/DmdB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02087">
        <property type="entry name" value="LEUD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="1 2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="3">
        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO19651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP47808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL34709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS90726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="160" mass="17500" checksum="4AA133335089B99C" modified="2016-09-07" version="1">METGTIFKFHNDLDTDQIIASQYLLLPNLDEMKGHAFESLDPDFSKKVKPGDFVVGGENFGCGSSREQAPGVLKALGVQAVVAKSFARIFYRNSINIGLPVIVCKDLPDEVNTGDKMVLHMSEGTVEANGKTYSCTKLPEYMQNILNQGGLIASLNKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174P610</accession>
    <name>A0A174P610_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation protein, YlmC/YmxH family</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">YlmC/YmxH family sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01907</name>
        <name evidence="3" type="ORF">ERS852523_01961</name>
        <name evidence="5" type="ORF">GT712_17510</name>
        <name evidence="4" type="ORF">GT728_10800</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A1</strain>
            <strain evidence="5 8">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000018">
        <property type="protein sequence ID" value="CUP54278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000023">
        <property type="protein sequence ID" value="MZL33674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000051">
        <property type="protein sequence ID" value="MZS90805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703528.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000004_gene1947"/>
    <dbReference type="EnsemblBacteria" id="CUO11995">
        <property type="protein sequence ID" value="CUO11995"/>
        <property type="gene ID" value="ERS852478_01907"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP54278">
        <property type="protein sequence ID" value="CUP54278"/>
        <property type="gene ID" value="ERS852523_01961"/>
    </dbReference>
    <dbReference type="GeneID" id="66493887"/>
    <dbReference type="eggNOG" id="COG1873">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014238">
        <property type="entry name" value="Spore_YlmC/YmxH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40061">
        <property type="entry name" value="PTHR40061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02888">
        <property type="entry name" value="spore_YlmC_YmxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO11995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP54278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="84" mass="9497" checksum="98474580A1950DC5" modified="2016-09-07" version="1">MKICELKQKEVINICTCRSLGCPIDAEFDCKSSQLTALILPGPGRFCCLFGRDNEYIIPWECISQIGDDIILVKIDEEKCFHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174P7F7</accession>
    <name>A0A174P7F7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor P</fullName>
            <shortName evidence="8">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">efp</name>
        <name evidence="16" type="ORF">BWLFYP14_02228</name>
        <name evidence="12" type="ORF">ERS852478_01901</name>
        <name evidence="13" type="ORF">ERS852523_01955</name>
        <name evidence="15" type="ORF">GT712_17540</name>
        <name evidence="14" type="ORF">GT728_10830</name>
    </gene>
    <organism evidence="13 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 17">2789STDY5834863</strain>
            <strain evidence="13 18">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="14 20 21" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 21">BIOML-A1</strain>
            <strain evidence="15 20">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="16 19" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000018">
        <property type="protein sequence ID" value="CUP54119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000023">
        <property type="protein sequence ID" value="MZL33680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000051">
        <property type="protein sequence ID" value="MZS90811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703519.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000004_gene1941"/>
    <dbReference type="EnsemblBacteria" id="CUO11830">
        <property type="protein sequence ID" value="CUO11830"/>
        <property type="gene ID" value="ERS852478_01901"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP54119">
        <property type="protein sequence ID" value="CUP54119"/>
        <property type="gene ID" value="ERS852523_01955"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="11">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="10">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO11830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUP54119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZL33680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZS90811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VUX65863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="185" mass="20552" checksum="F20602F935C0D78F" modified="2016-09-07" version="1">MISAGDFKNGITLEIDGNVCQIVEFQHVKPGKGAAFVRTKYKNIITGAVLEKSFRPTEKFPAARIERVDMQYLYDDGDLYYFMNVETYDQVGLTKDQVGDSLKFVKENEMVKICSHNGNVFAIEPPLFVELEVTETEPGFAGNTAQGATKPATVETGAQVQVPLFVNQGDKLKIDTRTGEYLSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174R8H4</accession>
    <name>A0A174R8H4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sensor histidine kinase graS</fullName>
            <ecNumber evidence="6">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">graS_2</name>
        <name evidence="5" type="synonym">graS_3</name>
        <name evidence="5" type="ORF">ERS852478_03688</name>
        <name evidence="6" type="ORF">ERS852523_02852</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
            <strain evidence="6 8">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO72004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="CUP80127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72004">
        <property type="protein sequence ID" value="CUO72004"/>
        <property type="gene ID" value="ERS852478_03688"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP80127">
        <property type="protein sequence ID" value="CUP80127"/>
        <property type="gene ID" value="ERS852523_02852"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HATPase_C"/>
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        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="17"/>
            <end position="34"/>
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="60"/>
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    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="129"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO72004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP80127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="337" mass="39364" checksum="0FA6FD42AFD9E390" modified="2016-09-07" version="1">METVSFFTFLEEKITEILFQLFFLALVAFLLIFYGVDTLFVVLLVILFISIQGLFQWCLYRKKRKASQHIIDLVDGLEETYYIADVLPKPKEFQNEAYYYALKKACKSMNDEIGKITEEKQDYQEYVESFAHEIKIPIGALSLTFDNTKNYTLKKETDKIFQLVEQMLYYARSENTEKDYFVKQLQLDEVIHNVILKFRHSLMERKVIINIHDIENVVYTDEKWLTFILSQIVQNAIKYFDKQENKLTIYSQDNGTNILLVIEDNGCGIKTSDLSRVFEKGFTGSNRNKANATGMGLYLSKKLCDRLGLKLDIASTEKEYTRLTIIFPKGTVHNFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174S9K6</accession>
    <name>A0A174S9K6_9FIRM</name>
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        <submittedName>
            <fullName evidence="7">Cobalt-precorrin-3B C(17)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </submittedName>
        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cbiH</name>
        <name evidence="8" type="synonym">cobJ</name>
        <name evidence="9" type="ORF">BWLFYP14_00107</name>
        <name evidence="6" type="ORF">ERS852478_02429</name>
        <name evidence="7" type="ORF">ERS852523_03267</name>
        <name evidence="8" type="ORF">GT728_01855</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 10">2789STDY5834863</strain>
            <strain evidence="7 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 13">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUP91930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL31978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1157"/>
    <dbReference type="EnsemblBacteria" id="CUO30902">
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        <property type="gene ID" value="ERS852478_02429"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP91930">
        <property type="protein sequence ID" value="CUP91930"/>
        <property type="gene ID" value="ERS852523_03267"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00148"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030789">
        <property type="term" value="F:precorrin-3B C17-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO30902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP91930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL31978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="243" mass="26728" checksum="48868261F2410EA8" modified="2016-09-07" version="1">MSKIYVIGIGPGAYDQMTGKAIRAMNESDAIIGYTVYVDLVKEYFPGKEFMTTPMKKEVDRCVLAFEEAKKGKTVSMICSGDAGVYGMAGLMYEVGVNYPETELEIIPGVTAATGGAAVLGAPLIHDFCLISLSDLLTPWEKIEARLLAAAQADFVVCLYNPSSKKRHDYLQKACDLMMKYKSPDTICGTVSNIAREGEEAHVMTLKELRDTQVDMFTTVFIGNSQTKEINNKMVTPRGYRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174T6F1</accession>
    <name>A0A174T6F1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02543</name>
        <name evidence="3" type="ORF">ERS852523_03737</name>
        <name evidence="4" type="ORF">GT712_19820</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO34948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000063">
        <property type="protein sequence ID" value="CUQ04636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000094">
        <property type="protein sequence ID" value="MZS91212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003060793.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000094.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34948">
        <property type="protein sequence ID" value="CUO34948"/>
        <property type="gene ID" value="ERS852478_02543"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ04636">
        <property type="protein sequence ID" value="CUQ04636"/>
        <property type="gene ID" value="ERS852523_03737"/>
    </dbReference>
    <dbReference type="GeneID" id="61431388"/>
    <dbReference type="GeneID" id="64112559"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO34948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ04636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS91212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="73" mass="8023" checksum="E8C7495C3CE2B658" modified="2016-09-07" version="1">MNFGQNLYQWFLSNAQSLVLMSIVVIGIYLGFKREFSKLIGFLVVALIAVGLVFNAGGVKDVLLELFNKIIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174TEN1</accession>
    <name>A0A174TEN1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="10">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="10">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">gatB</name>
        <name evidence="12" type="ORF">ERS852478_03331</name>
        <name evidence="13" type="ORF">ERS852523_03773</name>
        <name evidence="14" type="ORF">GT712_15000</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 15">2789STDY5834863</strain>
            <strain evidence="13 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 17">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000064">
        <property type="protein sequence ID" value="CUQ05279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000034">
        <property type="protein sequence ID" value="MZS90341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000041_gene2600"/>
    <dbReference type="EnsemblBacteria" id="CUO60920">
        <property type="protein sequence ID" value="CUO60920"/>
        <property type="gene ID" value="ERS852478_03331"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ05279">
        <property type="protein sequence ID" value="CUQ05279"/>
        <property type="gene ID" value="ERS852523_03773"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="11">
        <location>
            <begin position="328"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO60920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUQ05279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS90341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="479" mass="54514" checksum="64AF50E6FCB6C583" modified="2016-09-07" version="1">MKQYETVIGLEVHVELATKTKIFCGCSTEFGGAPNTHTCPVCTGMPGSLPVLNKKVVEFALKAGLAANCQIHQYCKFDRKNYFYPDNPQNYQISQLYLPICHDGWVEIETSAGKKKIRIHEMHMEEDAGKLIHDEWEDCSLVDYNRSGVPLIEIVSEPDMRSSEEVIAYLEKLRCMMQYLGVSDCKLQEGSMRADVNLSVREVGAEEFGTRTEMKNLNSFKAIARAIEGERERQIELIEEGKAVTQETRRWDDNKEYSYAMRSKEDAKDYRYFPDPDLPPIHISDAWIEKIKAEQPELREVKQARYQEEYGLPAYDAGILTESRHLAGLFEETAAIYGNAKKTANWFMGEVLRLTKDKAMDPEQVSFSPKHLADLLVMVEKSEVSPQNAKKVFEKVFEEDIDPVAYIEEHGLKIVEDTGLLEETINRILDANPGPLSELLGGKDKVMGFFVGQIMKEMKGKANPASVRETLMKEVEKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WUB1</accession>
    <name>A0A173WUB1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Na(+)-translocating NADH-quinone reductase subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199493.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43073">
        <property type="protein sequence ID" value="CUN43073"/>
        <property type="gene ID" value="ERS852478_00078"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_bind" evidence="2">
        <location>
            <begin position="154"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="2">
        <location>
            <begin position="274"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="2">
        <location>
            <begin position="424"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN43073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="500" mass="52140" checksum="85AE69EDB48E5D19" modified="2016-09-07" version="1">MDKNNEQKNNKTPETKPKQDSFRPWLKLIPAAAVFAAVCVTCYQADKSPVETTSVSNNNVMSTDEIKELISQGTAGKDFDSEDSSETNGTSISKTSKKTKKTSKIKTGTKKNSSTGSAANGGTARGGAGSTVTPTTEVPAGGYADGTYTGSGTGFGGTITVQVTVTDHKIAAINIVDASNETASYFANAQGVISKILASQSPNVDAVSGATYSSNGIITAVQNALSQAIPSGNQAVVTPTPTPSPKPTKKPSPIPKPGDEQIYKDGTYTGTGKGYSGTITLTAKIKKGMIKSLEAEHTDTPMFFKKAWDILENEIIQNQSVDGIDTVSGATYSSKGIINAMKDILKQAEKDTTKVTPTPTPEVTVTPTPEATPTPTPEETPTPEVTPTPEETPAPTPTPEETPEPTPEPTGPYIDGTYTGSSYGYSGRVNVTVTIQGGQIASIEQSNSDSPEYFDYAWETIYPQIMGNQSADGIDAASGATYSSEGILGAIQKALAQALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WVK2</accession>
    <name>A0A173WVK2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM family uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199501.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43542">
        <property type="protein sequence ID" value="CUN43542"/>
        <property type="gene ID" value="ERS852478_00094"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023862">
        <property type="entry name" value="CHP03960_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03960">
        <property type="entry name" value="rSAM_fuse_unch"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="256"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN43542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="623" mass="70827" checksum="B5AF3BAAF42B776D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X564</accession>
    <name>A0A173X564_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flp pilus assembly protein TadD, contains TPR repeats</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00171</name>
        <name evidence="4" type="ORF">GT728_06135</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MZL32795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45548">
        <property type="protein sequence ID" value="CUN45548"/>
        <property type="gene ID" value="ERS852478_00171"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="zinc_ribbon_2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN45548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="363" mass="41397" checksum="B06AEF5E9C4CD42E" modified="2016-09-07" version="1">MKCPKCHKEVEKGSLYCPYCLAEIPWVREFSTVETLMKKEQQNRPSEKKQKTEIIKYFKHPKRRKLKFSRKQLLCLLLCAATLLGFFCYRQLNTFSALYSRAKKQYAQQNYEEAQRIAENALDKNPKNEAANLLLAKSMEKSGDKRSALLVLRPFIQNKTAGTGIYKEYVKLLTQEGKTNEVRLILKSADREVQNACAEYICETPVSNPAPGTYTTTQTLKLEGNCQKIYYTLDGSTPTRKSKVYTEPIILREGTTKLKAFGVNDKNIESDVISRKYVIVLNAPKAPKVTPKSGDYNKKTEIKITVPDGCKAYYAFDSEPDLNSTVYEQPISMPVGYHRLNVILVAANGKTSKMTAMEYYLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X9X7</accession>
    <name>A0A173X9X7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidylate kinase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Cytidylate kinase-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00240</name>
        <name evidence="3" type="ORF">GT712_00260</name>
        <name evidence="2" type="ORF">GT728_15005</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 5 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A1</strain>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN47455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000041">
        <property type="protein sequence ID" value="MZL34472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993942.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000041.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN47455">
        <property type="protein sequence ID" value="CUN47455"/>
        <property type="gene ID" value="ERS852478_00240"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN47455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL34472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS87561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="195" mass="22912" checksum="281532604B1B089D" modified="2016-09-07" version="1">MSKRVITINRMLGSNGRLIGKALAEELGFAFYDKELIDIAAQKENIPFDLLAKVDEKRGSQWRFPIDHELQMDSDFHFVPMNDVLFDLQRKIILDAAEKEDCVIVGRCANHILDNKCLSVFIHAPFEYRVQTVIERTGREEKSAQKLVKKVDKERRTYYEYFTDKKWKDISQYHLAFDSSKFEQDKIIQMIKMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XZP6</accession>
    <name>A0A173XZP6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-galactarate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">garD</name>
        <name evidence="4" type="ORF">ERS852478_00466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UxaA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.42" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199649.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56317">
        <property type="protein sequence ID" value="CUN56317"/>
        <property type="gene ID" value="ERS852478_00466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008867">
        <property type="term" value="F:galactarate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11613">
        <property type="entry name" value="SAF_AH_GD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007392">
        <property type="entry name" value="Gal/Altron_deHydtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044144">
        <property type="entry name" value="UxaA/GarD_SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04295">
        <property type="entry name" value="GD_AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="3">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN56317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="496" mass="53963" checksum="61462C32AB130814" modified="2016-09-07" version="1">MPGKKEYIRINPADSVAVALQPLAKGTDIILDDVQFALLEDIPQGHKFALHTIEEGEPVIKYGNPIGHAKVNIPQGSWVHVHNMKTGLGDLIAYTYHPEKKDIKKRKPDEFMGFRRVDGSVGVRNEIWVIPTVGCVNSVAEKIAELSRKYCQGSVDTVVAFPHPYGCSQMGEDQENSRKILADLINHPNAGGVLVLGLGCENSGIDILKQYIGDYDGERIKFLNAQDCDDELEEGVRAVRELSAYAGTFKREPIPCSELIIGMKCGGSDGLSGITANPTVGGFSDLLISRGGTTILTEVPEMFGAETLLMNRCENEQLFDQTVHLINDFKNYFTSHNQTIYENPSPGNKKGGISTLEDKSLGCVQKSGTAPVKGVLAYGERVKNKGLNLLSAPGNDLVASTACAASGAHIVLFTTGRGTPFASPVPTVKISSNDRLYNKKNNWIDFNCGELVKEKSVEELSQKLYEYVLKVASGEKVKAEEAGFHDMAIFKQGVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y0U7</accession>
    <name>A0A173Y0U7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yqeY</name>
        <name evidence="1" type="ORF">ERS852478_00502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199682.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57514">
        <property type="protein sequence ID" value="CUN57514"/>
        <property type="gene ID" value="ERS852478_00502"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN57514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="145" mass="16210" checksum="EB783A5B4708808B" modified="2016-09-07" version="1">MELEVLRKDMVAAMKAKDKVTKEAVSSLISAVKKVAIDEGCRDEIKSDLVDRVILKELKTVKEQLDTCPESREDLKAEYQARYDVIAKYAPKQMDAAEVKAYLEEKFADVIAKKNKGQIMKAVMADMKGKADGKVINQVVAELCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y1S8</accession>
    <name>A0A173Y1S8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homospermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199688.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57849">
        <property type="protein sequence ID" value="CUN57849"/>
        <property type="gene ID" value="ERS852478_00512"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1748">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Sacchrp_dh_C" evidence="2">
        <location>
            <begin position="160"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN57849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="426" mass="48018" checksum="1BC1AF780F29FB55" modified="2016-09-07" version="1">MSRLLVIGCGGVASVAIRKCCQNSDVFTEIMIASRTKEKCDALKEKIESTTKTKIETAKIDADNAAEVAELIRAYKPDAVLNVALPYQDLTIMDACLEAGADYIDTANYEAEDTEDPTWRAIYEKRCKEKGFTAYFDYSWQWDYDEKFKKAGLTALLGTGFDPGVTSVFSAYALKHYFDEIHTIDILDCNGGDHGYPFATNFNPEINLREVSANGSYWEDGHWVETEPMEFKSVYDFPEVGKKDMYLLHHEEIESLAKNIPGVQRIRFFMTFGQSYLTHMKCLENVGMLSTAPVEFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGVKDGKEKSIYIYNVCDHQECYKEVESQAISYTTGVPAMIGSMMVVTGQWKKPGVFNVEEFDPDPYMEALNKWGLPWKVCEDPELVKVWKANED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y1T4</accession>
    <name>A0A173Y1T4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199658.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56668">
        <property type="protein sequence ID" value="CUN56668"/>
        <property type="gene ID" value="ERS852478_00476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025911">
        <property type="entry name" value="ToxN/AbiQ_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13958">
        <property type="entry name" value="ToxN_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN56668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="172" mass="20496" checksum="EE54BC5A11047FEB" modified="2016-09-07" version="1">MENESPILYYVDKEYLKYLHKEDYRVSVKFNNRPFAGIVTLVGDRKYIIPLTSQTTEERKNAGKNKRSSLITTFVTETSGKEISNLLYNNMIPVNEQIITALEIDPETDTYESNEIRYLRKNWETIKKKAEKIFNQRYDIESHNFNFLKKTCCDFKKLEKALDQFEIRQEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y3F3</accession>
    <name>A0A173Y3F3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arginine decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.19</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">speA_1</name>
        <name evidence="4" type="ORF">BWLFYP14_02110</name>
        <name evidence="3" type="ORF">ERS852478_00510</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN57776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000038">
        <property type="protein sequence ID" value="VUX65631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380826.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN57776">
        <property type="protein sequence ID" value="CUN57776"/>
        <property type="gene ID" value="ERS852478_00510"/>
    </dbReference>
    <dbReference type="GeneID" id="66492750"/>
    <dbReference type="eggNOG" id="COG1982">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000310">
        <property type="entry name" value="Orn/Lys/Arg_deCO2ase_major_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008286">
        <property type="entry name" value="Prn/Lys/Arg_de-COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01276">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03711">
        <property type="entry name" value="OKR_DC_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00703">
        <property type="entry name" value="OKR_DC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OKR_DC_1" evidence="2">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN57776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX65631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="485" mass="52820" checksum="C06D120B1A4FA618" modified="2016-09-07" version="1">MDYERQQHAPIYEALERFRKKRVVPFDVPGHKRGRGNPELAQLLGEKCVGLDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAFLMVGGTTSAVQSMILSVCKAGDKIILPRNVHKSAINALVLCGAIPVYVNPEVNAQLGISLGMEVSQVEKAMDENPDAVAVLVNNPTYYGICSDLRTIVKKAHARGMKVLADEAHGTHLYFGRNLPVSGMAAGADMAAVSMHKSGGSLTQSSLLLLNKSMNAEKVRQIINLTQTTSASYLLLSSLDISRRNLALRGEESFEKVAGMAQYAREEINEIGGYYAYGMDLINGTSVFDFDVTKLSIYTLGNGLAGIEVYDLLRDEYDIQIEFGDICNILAYISIGDRLQDIERLVGALADIERLYKKDSTGMLSGEYIAPAVVASPQQAFYAEKESLPMEQAAGRISGEFVMCYPPGIPILAPGEMVTQEIVEYILYARDKGCSMQGMEDPKVEHLQVLKGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y6C3</accession>
    <name>A0A173Y6C3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58696">
        <property type="protein sequence ID" value="CUN58696"/>
        <property type="gene ID" value="ERS852478_00541"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZFED">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN58696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="117" mass="13705" checksum="09AEDB9091082432" modified="2016-09-07" version="1">MNCKKIVSEIKDDDCYIAVNLGDWLKEQDIYDISVTEDNESEGYKEMYYERNPEKEEKDAFYDTDDTAYIPFERLVYEGDVISYTDSSIETVTEVEENGDFYTKITSTPKLPLKDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y9E4</accession>
    <name>A0A173Y9E4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="5 9">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">moeA</name>
        <name evidence="11" type="ORF">ERS852478_00578</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="5 9"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053032.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59867">
        <property type="protein sequence ID" value="CUN59867"/>
        <property type="gene ID" value="ERS852478_00578"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="8 9" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="10">
        <location>
            <begin position="182"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN59867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="420" mass="46113" checksum="80EF3B6CB2752F4A" modified="2016-09-07" version="1">MEGISVEQAVEQILQHTPVINETEETELNKAGGRVLAQDMVAGFDNPPFDRSPVDGYTCKAEDLAGATKEHPVRLKVMEEIDAGQYSEREIQQGQAVRIMTGAAIPNGCNCCIYQEDTDYGEDTVEVYSEQKRWSNYCFSGEDFKKGTTLLKKGTHIGYVEAAILAGMGVAKVPVYRQPRIVLLTTGDEVVEPGIPLPKGKIYNSNMTMLSARLRELGIESFHMEAVKDDPTVMSEKLKEAAKVADMIITTGGVSVGKKDIMHESLRLMGAERIFWRVKMKPGMPTLFSAYKKTSDITATDHCASEREIPIISLSGNPFGVAVSIELLIRPALEKMMQDPSIGLKEVNGIMADNFEKGIKGRRFIRAYLENGKFHLPNGLHSNGVLSSMAGCNCLIDTKTMENQESRSLNAGDKVGAILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y9I2</accession>
    <name>A0A173Y9I2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stage II sporulation protein E</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">spoIIE_1</name>
        <name evidence="2" type="ORF">ERS852478_00576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_070100109.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPB010000050.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59806">
        <property type="protein sequence ID" value="CUN59806"/>
        <property type="gene ID" value="ERS852478_00576"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039248">
        <property type="entry name" value="Ptase_RsbX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35801">
        <property type="entry name" value="PTHR35801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN59806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="400" mass="44900" checksum="998B1824AD746E4C" modified="2016-09-07" version="1">MKRNKHHGLNVEFDGLCMDFGHVSLNKKKEFLCGDCYKIEENDEDHVLVLSDGLGSGVKANILSTLTATMLSTMIINQVELDEAVRAVAKTLPVCSVRNLAYATFTVLNFQGKQVSLYQFDNPDAILIRDGELFDYPVETSMIEEKEIHKSCFELKDEDMLIIMSDGVTNAGMGKTTNGGWGRDDVMAFCRAKYHKGMSAQEMAGYLAEASLDLNLNETDDDITAIVLRMRHKQVVNLMIGPPSKEEHDERYLKSFFDSEGYHVICGGTTAQCAARYLDKELISLSETACGDVPAYYKLEGTELVTEGFLTIEHLLEYCEEWMEDRLSFNRLKRKKDAAALLGVMLFEQATDINFYFGGAINKSNVELGITEKRKEQVAEELVEHLQNAGKNVNIAFWAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="7" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YF88</accession>
    <name>A0A173YF88_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN62459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN62459">
        <property type="protein sequence ID" value="CUN62459"/>
        <property type="gene ID" value="ERS852478_00653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016130" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN62459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="48" mass="5221" checksum="46A7CE91F44B55DD" modified="2016-09-07" version="1">MKNKKWITLAAAVVLAVTSLPVTAFAEKKDSTDDKMLTKITLNSAENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YKG4</accession>
    <name>A0A173YKG4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjO_4</name>
        <name evidence="8" type="synonym">ycjO_1</name>
        <name evidence="7" type="ORF">ERS852478_00664</name>
        <name evidence="8" type="ORF">ERS852523_00682</name>
        <name evidence="9" type="ORF">GT712_03370</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
            <strain evidence="8 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN63817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP14027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578113.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000015_gene3742"/>
    <dbReference type="EnsemblBacteria" id="CUN63817">
        <property type="protein sequence ID" value="CUN63817"/>
        <property type="gene ID" value="ERS852478_00664"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP14027">
        <property type="protein sequence ID" value="CUP14027"/>
        <property type="gene ID" value="ERS852523_00682"/>
    </dbReference>
    <dbReference type="GeneID" id="66493436"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="77"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN63817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP14027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS88153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="299" mass="33207" checksum="4CDFCA7F8DF68803" modified="2016-09-07" version="1">MAAKSRTMAQQKTKEAYCFIVPAFIYMILVLGYPIVYNIILSLKDVNVKNLKSGTSVFVGLQNYIDLFHDPTFLLVLRNTFIFTIACLIFQFTIGFAFAMFFNQKFKLAGPIRGLILVSYMMPMAVTGLLGKNIFSNAGLINDLLGKIGISGPEWLVNTSTALIAVIIMNCWVGIPFNMLLLVSGLTSISPDVYESASMDGANWGQRFLFITLPLMKESILAVLMLGFIYTFRAFDLMYIMTAGGPLNSTDVLGTYSYMLSFTQFNFSKGAAVAMVLFACLFLIGLFYLKLLSKEEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YM67</accession>
    <name>A0A173YM67_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF4364 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01819</name>
        <name evidence="1" type="ORF">ERS852478_00689</name>
        <name evidence="2" type="ORF">ERS852523_00655</name>
        <name evidence="4" type="ORF">GT712_03245</name>
        <name evidence="3" type="ORF">GT728_03680</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP13223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706534.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000015_gene3717"/>
    <dbReference type="EnsemblBacteria" id="CUN64683">
        <property type="protein sequence ID" value="CUN64683"/>
        <property type="gene ID" value="ERS852478_00689"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP13223">
        <property type="protein sequence ID" value="CUP13223"/>
        <property type="gene ID" value="ERS852523_00655"/>
    </dbReference>
    <dbReference type="GeneID" id="66493466"/>
    <dbReference type="eggNOG" id="COG3432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025374">
        <property type="entry name" value="DUF4364"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14277">
        <property type="entry name" value="DUF4364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN64683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP13223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX65064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="170" mass="19754" checksum="008DA398D88E9060" modified="2016-09-07" version="1">MATPFTVYKLIVLYMLQNTENTLTNSQISEFILDREYTNYFHLQQAISELVEAELITMDTRSNVSHYRITEDGIKTLSFFQKDLSPEIKQEVREYLKSTGFKAQERIVTPADYYITKQGTYSVRCQLIEKGNSLIDLNIAAPNLEAAQSICKKWSTHYQEIYGKIMEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YNB3</accession>
    <name>A0A173YNB3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Autoinducer 2-binding protein lsrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199760.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64545">
        <property type="protein sequence ID" value="CUN64545"/>
        <property type="gene ID" value="ERS852478_00685"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="52"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN64545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="339" mass="37752" checksum="A7D2F87794AB40D7" modified="2016-09-07" version="1">MKKKRTKLLVFFALAGILVLFYMIGESYCEGLSGGSSLEEKNEVMCKYKYDMIVDSPNSSFWQAVYDCAQEWAQKNGAILELRGSGRESDYSKLDYMNMSIASNSDGIILQYSGEQGLEEKINEAVQKGIPVVTVMGDAVHSKRQSFVGVSDYQLGSVYGEKVAEYVTEDTESILILLKKNIDDMNQSQIYTQISNAAQAKAGSLQNIQITGKNLRLTGTFETEEAVTDIFQQRDKVPDILVCMDEETTECARQAVLDFNLAGKVTIIGYYSSEDILTAVEKGVISVTCDVDTEQLGRYSIEALTAYQKDGRTNSYYNVDINFLDKNAVREMRRKGVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YSY1</accession>
    <name>A0A173YSY1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flp pilus assembly protein TadD, contains TPR repeats</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00762</name>
        <name evidence="5" type="ORF">GT712_02945</name>
        <name evidence="4" type="ORF">GT728_03980</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A1</strain>
            <strain evidence="5 7">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380502.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67302">
        <property type="protein sequence ID" value="CUN67302"/>
        <property type="gene ID" value="ERS852478_00762"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252560" evidence="2">
        <location>
            <begin position="35"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN67302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="349" mass="38942" checksum="63C38CDDC0489ECA" modified="2016-09-07" version="1">MYNRKKRLFLTAVCLSLGLLTGCNVGDTKNYKQAAQDLEQGNYEAALEEYETAISEGVKPAQSYRGAGVAKLKLGNYEEAITYFNDALKCDKVGKALKKDILSYRAVAYLKVKDYEAALEDCQTLAENYKMDADLYFLTGETALAMDSYEEASANFEQAYGEDATYDRAIQIYGAYLNRDMEADGTRYLEAALSGTAKNAEDHCDRGRVYYYMDDYENAESELKQAIDGDNTEALVLLGMVYMDKGDSANAKAMFQQYVSQAENGAKGFNGLALCDIEDGDYDSALSDIESGIHVAGAEDMQSLLFNEIVVYEKKLDFQTALQKAQEYLELYPEDKTVKKELAFLKTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YYC2</accession>
    <name>A0A173YYC2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN67758">
        <property type="protein sequence ID" value="CUN67758"/>
        <property type="gene ID" value="ERS852478_00776"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016485" evidence="1">
        <location>
            <begin position="32"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN67758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="443" mass="49234" checksum="8DEC479D4DB132A9" modified="2016-09-07" version="1">MMKRKAMAITLTAAMLAGLTAVPTWAEDAAADEGKVLNIYCWNEEFKSRLTDHYPGYEEVDGTHGKIGDVDVVWNITPSDDNAYQNNLDETLLKQADAAADDKIDLFLVEADYALKYVNTDYTMSVADLGITDEEVADQYQYTKDVMTDSDGNLKGLSWQGCPGAMIYRRDIAKEVFGSDDPAEVQKKVADWDTFKATAEELKEKGYQMTSTVNDAYRVFSNNVTSPWVVDGKITVDDNIKNWVDMSKEMVDAGETATYELWSDDWSKGFFKDSNVFSYFGPAWFIDFSMSADQDGSVGKDGGWAATEGPQGFYWGGTWITAAAGTDNPTLVADIMRTMTTNVDVMKEIVTADNDFVNNKPAMEEMAKDESYGDAVLGGQNPLAMFCAGADKIDLSNMSIYDQGCNEEFQNAMKNYFEGNASYDEALDLFYKAVVEKYPELSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YZB9</accession>
    <name>A0A173YZB9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc transporter ZupT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">zupT</name>
        <name evidence="7" type="synonym">zupT_1</name>
        <name evidence="7" type="ORF">BWLFYP14_01702</name>
        <name evidence="6" type="ORF">ERS852478_00810</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055058205.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN68967">
        <property type="protein sequence ID" value="CUN68967"/>
        <property type="gene ID" value="ERS852478_00810"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN68967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX64845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="260" mass="27243" checksum="59EA366D7BEB7A9A" modified="2016-09-07" version="1">MDINVFYGILIPFLGTSAGAACVFFMKKNLNEQIQRALTGFAAGVMVAASIWSLLIPAIEQSSGLGKLSFVPAAVGFWIGVLFLLLLDHMIPHLHQNSDKAEGPKSKLQRTTMLVLAVTLHNIPEGMAVGVVYAGYLTGHAQITIMGAMALSIGIAIQNFPEGAIISMPLRSEGMGKTKAFAGGVLSGIVEPIGAVLTILAAGLIVPALPYLLSFAAGAMLYVVVEELIPEMSAGEHSNIGTIFFAVGFSLMMILDVALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z952</accession>
    <name>A0A173Z952_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpG_1</name>
        <name evidence="9" type="synonym">atpG</name>
        <name evidence="10" type="ORF">ERS852478_00912</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199841.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72942">
        <property type="protein sequence ID" value="CUN72942"/>
        <property type="gene ID" value="ERS852478_00912"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN72942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="296" mass="33978" checksum="5468184ED3B77519" modified="2016-09-07" version="1">MGSTKEIQTRMKSIQDTMKITNAMYMISSSKMQKAKRILSDTEPYYYNMQAAISRILRHMPDTEHPFFSIRHKIAEEDRKIGCIVVTGDKGMAGAYNHNIQKMTEQFMAEHELCKLYVLGMVGRQYFTKKHMDIAENFPYTVQKPTMHRARLISEEIVRAFLDRELDEVRIFYTEMQSAVAMEPVNMQLLPLKKAEFLPNQAMLADMPQEEIVLSPSADVLLNTMIPNYLTGLIYGCLVEAYASENNARMMAMQSSTDSAKKMLRELSIEYNRARQAAITQEITEIVSGAKAQKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z9F9</accession>
    <name>A0A173Z9F9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_03342</name>
        <name evidence="1" type="ORF">ERS852478_00900</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002594231.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72537">
        <property type="protein sequence ID" value="CUN72537"/>
        <property type="gene ID" value="ERS852478_00900"/>
    </dbReference>
    <dbReference type="GeneID" id="61912439"/>
    <dbReference type="GeneID" id="66495694"/>
    <dbReference type="eggNOG" id="ENOG5032YE1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026990">
        <property type="entry name" value="TnpW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14202">
        <property type="entry name" value="TnpW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN72537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX67065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="64" mass="7007" checksum="01D8B704BE124C8B" modified="2016-09-07" version="1">MTDTQRNKRPARRPDCVTETRIGNTILVVSGFFKEGATDTAADKMMKVLEAEAAAGYLTCDKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZDY3</accession>
    <name>A0A173ZDY3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamine phosphate synthase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2 4">regulatory protein tenI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tenI</name>
        <name evidence="4" type="ORF">BWLFYP14_01326</name>
        <name evidence="2" type="ORF">ERS852478_00956</name>
        <name evidence="3" type="ORF">GT728_01455</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74267">
        <property type="protein sequence ID" value="CUN74267"/>
        <property type="gene ID" value="ERS852478_00956"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TMP-TENI" evidence="1">
        <location>
            <begin position="10"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN74267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL31899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="191" mass="21402" checksum="981C77F6BA102F37" modified="2016-09-07" version="1">MQKNPYENVIAVTNRSLCQRPFAEQIERVCSLHPKAVILREKDLPEEEYSRLAEQILEICKRYQVPCILHTYVNVAEKLHHPYIHLPIFLLEKYEGKLGGFRQIGSSVHSVEDALKAESLGADYLTAGHIYTTDCKKGLPPRGLEFLENVCKAVKIPVYAIGGIHPGTGQLNEIMEHGSAGGCIMSDMMKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZGA4</accession>
    <name>A0A173ZGA4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin-antitoxin biofilm protein TabA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tabA</name>
        <name evidence="1" type="ORF">ERS852478_00974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199862.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74793">
        <property type="protein sequence ID" value="CUN74793"/>
        <property type="gene ID" value="ERS852478_00974"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004375">
        <property type="entry name" value="NanQ/TabA/YiaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037012">
        <property type="entry name" value="NanQ/TabA/YiaL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34986">
        <property type="entry name" value="PTHR34986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04074">
        <property type="entry name" value="DUF386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00022">
        <property type="entry name" value="TIGR00022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN74793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="151" mass="17221" checksum="18EB7DA429FF10B4" modified="2016-09-07" version="1">MIYTDLNNLERYLGMGKHLDTAIHYIKEHSLNDLKKGRNEVDGDFAFINCFEYETLPEEKTAFEAHEKYADIHMVISGEEKMGVSDMSLMTVTAKDEETDSIECHGPVEHYMDLTPGKVLIVFPEDAHKVKIMKDQISQVRKAVGKVLVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZH02</accession>
    <name>A0A173ZH02_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutathione transport system permease protein gsiD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gsiD_2</name>
        <name evidence="7" type="ORF">ERS852478_00977</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74910">
        <property type="protein sequence ID" value="CUN74910"/>
        <property type="gene ID" value="ERS852478_00977"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="93"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN74910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="297" mass="32325" checksum="B56CCBB432D7CE10" modified="2016-09-07" version="1">MMSQSAVDMKKEKKTAASSLFKKNVKKFMNNKLALLGLLVIVIMTVACIIGAIAGVDYVTPHLPDMKKAPGNGYLFGTDTMGRDLFARVLIGGCYSILIGVFCAVLSSVIGAILGAIAGYFGGKTDAAIIRISEIFQAFPQLVLVMMLVAIVNKRGLGNLLFIFVFTGWMTTFRMVRNEFVSIKGETYVKVCEAFGMSRMNIMFKQILPNVMSPIIVSTTTNVAFFILQEAALSFIGLGVADSTPTWGNILNAAKSVSVVTNQWWIWVFPGLAITLFVLAINFLGDGIRDVMDAKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZP66</accession>
    <name>A0A173ZP66_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT family N-acetyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-alanine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01042</name>
        <name evidence="3" type="ORF">GT728_13680</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN77015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000034">
        <property type="protein sequence ID" value="MZL34228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580832.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN77015">
        <property type="protein sequence ID" value="CUN77015"/>
        <property type="gene ID" value="ERS852478_01042"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN77015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="213" mass="24989" checksum="C603249CE2B0B31A" modified="2016-09-07" version="1">MESDNLYRVQEEDLPRLQKLLTVCFAQDPLYHTLIPDDDTRERLLPELFSCDLTEFFQTCEIYSDSSELNSILVVSDESEPYNFLHYCLTEARAALTTDGWLIKEDPSLKTFWNFIQGKDYLNSSWTDQLHQTERLHVIYLAVDPGHQHHGLAELLMDEVINYAQKHKMLISLETHNPNNVPIYEHFGFKTYGIVEKPHFDLKQYCMIREATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZRY5</accession>
    <name>A0A173ZRY5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Na(+)/dicarboxylate symporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Sodium-dependent dicarboxylate transporter SdcS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sdcS</name>
        <name evidence="7" type="ORF">BWLFYP14_00336</name>
        <name evidence="6" type="ORF">ERS852478_01056</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055052529.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000144.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78563">
        <property type="protein sequence ID" value="CUN78563"/>
        <property type="gene ID" value="ERS852478_01056"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00785">
        <property type="entry name" value="dass"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN78563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX67491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="421" mass="44200" checksum="F2E356F02534EBB0" modified="2016-09-07" version="1">MSQQTITLLFLVFTIISFILEKIPLGLTASICAIGLTLTGVVDVSTTFSQYVNSNVILCVGMFVVGQALFETGMANKIGGLVTRFARTERTLIIAIMVIVGVMSGFLSNTGTAAVLIPVVCGIADESGYSRSRLLMPLVFAAALGGNLSIIGAPGNLMGVNALQEMGLSTSFFMYAPVGVPMLLVGIIYFVFIGYRFLPDGKGAVGATVEKQKDFSDVPKWKQTVSLIVLILVILAMIFEKQIGVSIEISACIGAIILVLFGVLSEKEALASIDLKVVFLFGGSLTLAKALDTTGAGELIADKIVGLLGADPNPIVLLLVIFIVTCALTNFMSNTATTALMIPIAVSLANNLGADPRAVVIATVIAGSCAYATPIGMPANTMVVGLGGYKFKDYVKSGLPLILVSFVICMILLPVLFPFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZVG5</accession>
    <name>A0A173ZVG5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purB</name>
        <name evidence="15" type="ORF">BWLFYP14_03125</name>
        <name evidence="12" type="ORF">ERS852478_01108</name>
        <name evidence="13" type="ORF">ERS852523_00430</name>
        <name evidence="14" type="ORF">GT712_10525</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">2789STDY5834863</strain>
            <strain evidence="13 17">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="14 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 19">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="15 18" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP06537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000019">
        <property type="protein sequence ID" value="MZS89492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994086.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000066.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000045_gene2071"/>
    <dbReference type="EnsemblBacteria" id="CUN80442">
        <property type="protein sequence ID" value="CUN80442"/>
        <property type="gene ID" value="ERS852478_01108"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06537">
        <property type="protein sequence ID" value="CUP06537"/>
        <property type="gene ID" value="ERS852523_00430"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="11">
        <location>
            <begin position="370"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN80442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUP06537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS89492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VUX66849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="477" mass="53838" checksum="87188618177E60E7" modified="2016-09-07" version="1">MSTDRYVSPLSERYASKEMQYIFSPDMKFRTWRRLWIALAETEKELGLNITQEQIDELKAHAEDINYDVAKERERQVRHDVMSHVYAYGVQCPKAKGIIHLGATSCYVGDNTDIIVMTEALKLVKKKLVNVIAELSAFADKYKDQPTLAFTHFQPAQPTTVGKRATLWTQEFLLDLEDLEYVLGTMKLLGSKGTTGTQASFLELFDGDQETIDKIDPMIAEKMGFKECYPVSGQTYSRKVDTRVANILAGIAASAHKMSNDIRLLQHLKEVEEPFEKSQIGSSAMAYKRNPMRSERIASLSRYVMVDALNPAITSATQWFERTLDDSANKRLSIPEGFLAIDGILDLCLNVVDGLVVYPKVIEKHMMAELPFMATENIMMDAVKAGGDRQELHERIRELSMEAGKTVKVEGKDNNLLELIAADPAFNLSLEDLQRSMDPKKYIGRAKEQTERFVNTVVQPILDSHKELLGVKAEINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZWV4</accession>
    <name>A0A173ZWV4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sigE</name>
        <name evidence="13" type="synonym">sigE_3</name>
        <name evidence="13" type="ORF">BWLFYP14_03118</name>
        <name evidence="9" type="ORF">ERS852478_01115</name>
        <name evidence="10" type="ORF">ERS852523_00437</name>
        <name evidence="12" type="ORF">GT712_10560</name>
        <name evidence="11" type="ORF">GT728_00875</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP06703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000019">
        <property type="protein sequence ID" value="MZS89499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020994083.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2184"/>
    <dbReference type="EnsemblBacteria" id="CUN80704">
        <property type="protein sequence ID" value="CUN80704"/>
        <property type="gene ID" value="ERS852478_01115"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06703">
        <property type="protein sequence ID" value="CUP06703"/>
        <property type="gene ID" value="ERS852523_00437"/>
    </dbReference>
    <dbReference type="GeneID" id="66493269"/>
    <dbReference type="eggNOG" id="COG1191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014200">
        <property type="entry name" value="RNA_pol_sigma-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02835">
        <property type="entry name" value="spore_sigmaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN80704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP06703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL31785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS89499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX66842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="236" mass="26798" checksum="0351563289D94A8C" modified="2016-09-07" version="1">MSCYPLQVVSRMVMNRSGEVFYIGGNDVLPAPLEPKREAFILQKLGTGQEEEAKSVLIEHNLRLVVYIAKKFDNTGVGVEDLISIGTIGLIKAINTFNPVKNIKLATYASRCIENEILMYLRRNSKTKMEVSIDEPLNVDWDGNELLLSDILGTDEDVISRRLEDEVEISLLSKAIRKLSPREQTIIRLRFGLGKENAAEKTQKEVADLLGISQSYISRLEKRIMKRLKKEIVKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZXM0</accession>
    <name>A0A173ZXM0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydroxylamine reductase</fullName>
            <ecNumber evidence="7">1.7.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Hybrid-cluster protein</fullName>
            <shortName evidence="7">HCP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Prismane protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">hcp</name>
        <name evidence="8" type="ORF">ERS852478_01096</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine</text>
            <dbReference type="Rhea" id="RHEA:22052"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15429"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="1.7.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </cofactor>
        <text evidence="7">Binds 1 hybrid [4Fe-2O-2S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the HCP family.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.1" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199920.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79975">
        <property type="protein sequence ID" value="CUN79975"/>
        <property type="gene ID" value="ERS852478_01096"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050418">
        <property type="term" value="F:hydroxylamine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01914">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00069">
        <property type="entry name" value="Hydroxylam_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004137">
        <property type="entry name" value="HCP/CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010048">
        <property type="entry name" value="Hydroxylam_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016100">
        <property type="entry name" value="Prismane_a-bundle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109">
        <property type="entry name" value="PTHR30109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109:SF0">
        <property type="entry name" value="PTHR30109:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03063">
        <property type="entry name" value="Prismane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000076">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01703">
        <property type="entry name" value="hybrid_clust"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="7">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Cysteine persulfide" evidence="7">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN79975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="532" mass="58017" checksum="5F48D8F6026CC253" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A168</accession>
    <name>A0A174A168_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Farnesyl diphosphate synthase</fullName>
            <ecNumber evidence="4">2.5.1.10</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Polyprenyl synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BWLFYP14_03069</name>
        <name evidence="4" type="ORF">ERS852478_01165</name>
        <name evidence="6" type="ORF">GT712_03590</name>
        <name evidence="5" type="ORF">GT728_00365</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 11">BIOML-A1</strain>
            <strain evidence="6 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.10" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704093.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN82402">
        <property type="protein sequence ID" value="CUN82402"/>
        <property type="gene ID" value="ERS852478_01165"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:geranyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="259"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN82402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL31686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS88195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="295" mass="32987" checksum="8B3F6A3C4747D989" modified="2016-09-07" version="1">MNFQDELAKRTEETEKVIRSFLPAEAGFAGTMAQAMNYSMLAGGKRLRPMLIRETYRLFDGKEEVVKPFMAGMEMIHTHSLIHDDLPALDDDDYRRGRLTTHKVYGEAMGVLSGVALLNYAYETMFQAFALTKEQDRVIHALRVVSQKTGIHGMLGGQSVDVENDGKPLEKEMLDYIYRNKTSALIEASMMTGAILAGANEQEVSAVEKAAGNIGLAFQIQDDILDVTSTAEELGKPVHSDEKNNKVTYVTLFGTEKAAEQVEELSEKAIDLLKSLNKNNEFLYLLIEKLINRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A6V3</accession>
    <name>A0A174A6V3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">trpS2</name>
        <name evidence="9" type="ORF">ERS852478_01218</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN84371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199969.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000027.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84371">
        <property type="protein sequence ID" value="CUN84371"/>
        <property type="gene ID" value="ERS852478_01218"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN84371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="353" mass="40081" checksum="FE3D3CCBE5DD460F" modified="2016-09-07" version="1">MSKIILTGDRPTGRLHVGHYVGSLSERVRLQNSGLYDEIYIMIADAQALTDNAEHPEKVRQNILQVALDYLACGIDPEKSTIFIQSMVPELTELTFYYMNLVTVARVQRNPTVKAEIQMRNFEASIPVGFFCYPISQAADITAFRATTVPVGEDQLPMLEQCKEIVHKFNTVYGETLTEPEIILPSNKACLRLPGIDGKAKMSKSLGNCIYLSDEEADVKKKVMSMFTDPNHLRVEDPGRVEGNPVFIYLDAFCKPEYFAEFLPEYQNLDELKAHYTRGGLGDVKVKKFLNKVLQAELSPIRERRKYWEQHLDDVYDILKEGSKVAEAKAAQTLHDVRSAMQINYFDDNSLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ACE7</accession>
    <name>A0A174ACE7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type IV secretion system component VirD4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VirD4/TraG family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199981.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86301">
        <property type="protein sequence ID" value="CUN86301"/>
        <property type="gene ID" value="ERS852478_01241"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003688">
        <property type="entry name" value="TraG/VirD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02534">
        <property type="entry name" value="T4SS-DNA_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN86301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="596" mass="67043" checksum="9704F1383624BD4E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AIQ0</accession>
    <name>A0A174AIQ0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_01292</name>
        <name evidence="8" type="ORF">GT728_08265</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000015">
        <property type="protein sequence ID" value="MZL33191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057239.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88093">
        <property type="protein sequence ID" value="CUN88093"/>
        <property type="gene ID" value="ERS852478_01292"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="417"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN88093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL33191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="519" mass="59934" checksum="4CBC48E0EB35F160" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AJ01</accession>
    <name>A0A174AJ01_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">3'-5' Exoribonuclease YhaM</fullName>
            <ecNumber evidence="2 3">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yhaM</name>
        <name evidence="3" type="ORF">BWLFYP14_01616</name>
        <name evidence="2" type="ORF">ERS852478_01274</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="2 3"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705648.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000107.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87436">
        <property type="protein sequence ID" value="CUN87436"/>
        <property type="gene ID" value="ERS852478_01274"/>
    </dbReference>
    <dbReference type="GeneID" id="66494967"/>
    <dbReference type="eggNOG" id="COG3481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="161"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN87436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX64762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="315" mass="35436" checksum="7C33B40CBF776E12" modified="2016-09-07" version="1">MRFLNELHEGDRINGIYLCKQKQSAVTKNGKPYENIILQDKTGIMDGKIWDPNSLGIDDFDALDYIDVVGDVTSFAGAMQLNIKRVRKAAEDEYDPADYLPVSENSTDDMYSQLRAFIDSVENTYLSALLKKLFVEDEAFVKAFEGHSAAKTVHHGFIGGLMEHTLGVTRLCDYMSKAYPVINRDLLITASLLHDIGKTKELSAFPLNDYTDEGQLLGHIYMGAQMINDLAHQIPEFPEVLKNELIHCILSHHGELEYGSPKKPALVEAVALNLADNTDARMETITEIFAANKSKKEWLGYNKLFESNLRRTDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AQ82</accession>
    <name>A0A174AQ82_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">adaA_2</name>
        <name evidence="7" type="ORF">ERS852478_01338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89760">
        <property type="protein sequence ID" value="CUN89760"/>
        <property type="gene ID" value="ERS852478_01338"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="5">
        <location>
            <begin position="430"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN89760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="534" mass="61873" checksum="F00EA7C72FE3998A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B1M0</accession>
    <name>A0A174B1M0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200088.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94119">
        <property type="protein sequence ID" value="CUN94119"/>
        <property type="gene ID" value="ERS852478_01441"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN94119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="120" mass="13553" checksum="45826A0F85D13932" modified="2016-09-07" version="1">MISPFGLMYLRPGSLWTDFVVRRKSIRNILGHPVSDFEAKGEISGILAEASTHESERMKHRWDQEQHSLTHTLVIRDSADVKQGDYLTTAGRTFLVLLSEDPGNLGATGLIYLEERNDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B5T9</accession>
    <name>A0A174B5T9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative protease YhbU</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">U32 family peptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Uncharacterized protease yhbU</fullName>
            <ecNumber evidence="3 5">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhbU_2</name>
        <name evidence="5" type="ORF">BWLFYP14_00979</name>
        <name evidence="3" type="ORF">ERS852478_01499</name>
        <name evidence="4" type="ORF">GT728_11000</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.-.-" evidence="3 5"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000024">
        <property type="protein sequence ID" value="MZL33711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380996.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96187">
        <property type="protein sequence ID" value="CUN96187"/>
        <property type="gene ID" value="ERS852478_01499"/>
    </dbReference>
    <dbReference type="GeneID" id="66492603"/>
    <dbReference type="eggNOG" id="COG0826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020988">
        <property type="entry name" value="Pept_U32_collagenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12392">
        <property type="entry name" value="DUF3656"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01276">
        <property type="entry name" value="PEPTIDASE_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3656" evidence="2">
        <location>
            <begin position="332"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN96187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX63493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="731" mass="83365" checksum="D7A2B72CCA879363" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B755</accession>
    <name>A0A174B755_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane assembly lipoprotein YfgL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95596">
        <property type="protein sequence ID" value="CUN95596"/>
        <property type="gene ID" value="ERS852478_01484"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN95596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="623" mass="68789" checksum="00EA585471B87354" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B822</accession>
    <name>A0A174B822_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conjugal transfer coupling protein TraG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VirD4/TraG family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200124.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97171">
        <property type="protein sequence ID" value="CUN97171"/>
        <property type="gene ID" value="ERS852478_01526"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003688">
        <property type="entry name" value="TraG/VirD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02534">
        <property type="entry name" value="T4SS-DNA_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN97171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="601" mass="68198" checksum="E35CBE4D1EB75C2B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B859</accession>
    <name>A0A174B859_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381109.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97211">
        <property type="protein sequence ID" value="CUN97211"/>
        <property type="gene ID" value="ERS852478_01527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN97211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="75" mass="8835" checksum="93AD89EFED609295" modified="2016-09-07" version="1">MGHSDEWTFADYFRYEKEIYRAIISAAVLCQWIAEHDTPPTDGEAEELVREIDRRLCEAWGEIFSLAVLKWRDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BA49</accession>
    <name>A0A174BA49_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="3 8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">recG</name>
        <name evidence="12" type="ORF">BWLFYP14_00969</name>
        <name evidence="11" type="ORF">ERS852478_01509</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 8"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380999.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96535">
        <property type="protein sequence ID" value="CUN96535"/>
        <property type="gene ID" value="ERS852478_01509"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="269"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="452"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN96535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX63483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="684" mass="76840" checksum="16649F1A87EEF42A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BA75</accession>
    <name>A0A174BA75_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_00968</name>
        <name evidence="2" type="ORF">ERS852478_01510</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96568">
        <property type="protein sequence ID" value="CUN96568"/>
        <property type="gene ID" value="ERS852478_01510"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033BRY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046313">
        <property type="entry name" value="DUF6465"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20069">
        <property type="entry name" value="DUF6465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN96568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX63482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="219" mass="24418" checksum="063858FCD77C95D5" modified="2016-09-07" version="1">MATKATTADLNTSTAKTTEVKEAPAKTTAEEVAVNKEANKKETAETETVKKETTAKKPAARRTRKTAEKKSAEAEKETEKKETAKAADTVEKKPAETEKEAEKKETAKTTKTAAKPTKTTKRTTKKAPAKTAEKPAEETAAEKKTTRRTTKKEATAEVYIQFMGREVYTKNILSNVRRIWTDELGKKEKDLKDIKIYIKPEENKAYYVINGDITGSVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BAU3</accession>
    <name>A0A174BAU3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphorylated carbohydrates phosphatase TM_1254</fullName>
            <ecNumber evidence="1">3.1.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN98152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004611585.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98152">
        <property type="protein sequence ID" value="CUN98152"/>
        <property type="gene ID" value="ERS852478_01554"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN98152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="218" mass="24699" checksum="8F949202F52127D6" modified="2016-09-07" version="1">MDFNAAIFDLDGTILDSMDVWEHIDIQFLKKRNLPVPENYVTEICARSFEEAAQYTIDLLGLQETVEGIIEEWNNMAVEEYSNHVGLLPHALDYLLRLKEHGIKLAVATGLPEKLYIPCLKNNSILELFDALCSTDEVQRGKEYSDVFELAARKLGVAPEHCIVFDDVLPAIKSAKAARMLAGGIYDKYSADQRTEIERIADIYLLDFRQAPIPHKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BFI7</accession>
    <name>A0A174BFI7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized ABC transporter ATP-binding protein YbhF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybhF_2</name>
        <name evidence="5" type="ORF">ERS852478_01561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN98388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004611594.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000097.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98388">
        <property type="protein sequence ID" value="CUN98388"/>
        <property type="gene ID" value="ERS852478_01561"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN98388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="305" mass="34365" checksum="6778183554935AEA" modified="2016-09-07" version="1">MTKFICETKNLSKKYKDFYALKNVNLTIPKGEIYGLVGENGAGKTTLIRLLTGLNFKSEGEIILFGHKDNLQHERSKIGCTIEMPALYKDMTASQNLEVQRIQRGIPNKKCITDTLELIGLSNAGKKRVANFSLGMKQRLALGVALLGEPEFLILDEPVNGLDPTGIIELRELLKKLVKEREVTILISSHILSELHQLATCYGFLHKGELLKQISTEELNEECKRHICLRTDNIQKTTLLLEQKGNINNYSVYPDNSIRIYECLDNVRMISKLLSSNGVIIDEISVQGENLETYFENLIGGRKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BPI5</accession>
    <name>A0A174BPI5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rplB</name>
        <name evidence="8" type="ORF">ERS852478_01660</name>
        <name evidence="9" type="ORF">ERS852523_01292</name>
        <name evidence="11" type="ORF">GT712_08975</name>
        <name evidence="10" type="ORF">GT728_04705</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">2789STDY5834863</strain>
            <strain evidence="9 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="10 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">BIOML-A1</strain>
            <strain evidence="11 14">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707253.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2981"/>
    <dbReference type="EnsemblBacteria" id="CUO02684">
        <property type="protein sequence ID" value="CUO02684"/>
        <property type="gene ID" value="ERS852478_01660"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33582">
        <property type="protein sequence ID" value="CUP33582"/>
        <property type="gene ID" value="ERS852523_01292"/>
    </dbReference>
    <dbReference type="GeneID" id="66496123"/>
    <dbReference type="eggNOG" id="COG0090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="7">
        <location>
            <begin position="124"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO02684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP33582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZL32519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS89200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="281" mass="30384" checksum="7458F551C000E02A" modified="2016-09-07" version="1">MGIKSYNPYTPSRRHMTGSDFSEITKSTPEKSLTVSLKKNAGRNNQGKITVRHRGGGSRRKYRIIDFKRRKDGIPATVVSIEYDPNRTANIALISYVDGEKAYILAPEGLKVGQKVMNGADAEVRVGNCLPLELIPVGTMVHNIELHPGKGGQMVRSAGNGAQLMAKEGKYATLRLPSGEMRMVPIVCRASVGVVGNGDHNLINIGKAGRKRNMGIRPTVRGSVMNPNDHPHGGGEGKTGIGRPGPCTPWGKPALGLKTRKKNKPSNKLIVRRRDGKALSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BR06</accession>
    <name>A0A174BR06_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rpsD</name>
        <name evidence="12" type="ORF">BWLFYP14_00281</name>
        <name evidence="10" type="ORF">ERS852478_01683</name>
        <name evidence="11" type="ORF">GT712_08855</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707284.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO03521">
        <property type="protein sequence ID" value="CUO03521"/>
        <property type="gene ID" value="ERS852478_01683"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="87"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO03521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS89176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX67440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="197" mass="22670" checksum="F9597CC71903DD3A" modified="2016-09-07" version="1">MAVNRVPVLKRCRSLGLDPIYLGIDKKSTRQLKRANRKMSEYGLQLREKQKAKFIYGVLEKPFHNYYDKADRMPGQTGANLMILLESRLDNVVFRMGFARTRKEARQIVDHKHVLVNGKCVNIPSYLVKAGDQIEIREKSKGSERYKGILEVTGGRLVPEWIDVDQENLKGTVKELPNREAIDVPVNEMLIVELYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BYI0</accession>
    <name>A0A174BYI0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO04685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009247521.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPK010000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO04685">
        <property type="protein sequence ID" value="CUO04685"/>
        <property type="gene ID" value="ERS852478_01698"/>
    </dbReference>
    <dbReference type="GeneID" id="61850122"/>
    <dbReference type="GeneID" id="66882332"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019646">
        <property type="entry name" value="Aminoglyc_AdlTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10706">
        <property type="entry name" value="Aminoglyc_resit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO04685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="165" mass="19190" checksum="ECEE31438C0F6322" modified="2016-09-07" version="1">MVRTEDACEIIKYALQNEIKVYLDGGWGVDALLKRESRIHNDIDLFVELKHYHDYIYVIKQHGFEEVNTDYTTDGHTVWKDDKQRIIDLHCFEFTDDGIVYEGDIFPSKTFSGIGKVGDITVSCIEPLSQVMLHLGYEHDKNDVHDVMLLCETFQIAIPDEYKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BYU8</accession>
    <name>A0A174BYU8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06401">
        <property type="protein sequence ID" value="CUO06401"/>
        <property type="gene ID" value="ERS852478_01750"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO06401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="49" mass="6045" checksum="42A5886B4258CAB4" modified="2016-09-07" version="1">MINLPEVIQEMLSYKESLGFSRKTYENYLSDFNKYFSNYSQDHAIYFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C302</accession>
    <name>A0A174C302_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arabinose operon regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">araC_2</name>
        <name evidence="3" type="ORF">ERS852478_01746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025578269.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06270">
        <property type="protein sequence ID" value="CUO06270"/>
        <property type="gene ID" value="ERS852478_01746"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037923">
        <property type="entry name" value="HTH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51215">
        <property type="entry name" value="SSF51215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="178"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO06270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="289" mass="33713" checksum="11DD8E455EA61491" modified="2016-09-07" version="1">MINVSGHLRNERRVTGFADDSVSLSVNCCGMQVFKTKDYSQNRFAGRVDYQLIYVYKGAGHYWLNNERKVLGAGNILLFRPKEPQIYSYYANEHPEIYWIHFTGNNCKNIIEKYNLHNCYIGEHTMLKTLFQETIIELQLKKPFFEDVVLCNFLQILAVIARYHQQILSPLGNDFSIDRLIMQLNQRYKDNWNVASMAEYCKLSVGYFSHIFKKRIGVAPMRYLNELRVEKAKELIATNAMKLSDIASMVGFSDPLYFSRVFKKTAGIPPKEFQQSLLTSNTPKWWPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C9W4</accession>
    <name>A0A174C9W4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Purine nucleotide synthesis repressor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purR_4</name>
        <name evidence="5" type="ORF">ERS852478_01821</name>
        <name evidence="6" type="ORF">GT728_18315</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000069">
        <property type="protein sequence ID" value="MZL35079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200306.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000069.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08675">
        <property type="protein sequence ID" value="CUO08675"/>
        <property type="gene ID" value="ERS852478_01821"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO08675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL35079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="346" mass="38751" checksum="135C24522690FB77" modified="2016-09-07" version="1">MTLREIAAEAGVSISTVSRVINQSTNSPVSREVQDRIWEIAKRTNYIPRHSKKNTVEPDSSSTEPFRSIACLFARVPDGASDYFFSTLAKNIEQEAFRHNYILKYTFSAFDIDDPFTLQLIASNDIDGIAVLGRCDKELLKFLKKHFQYVVYSGLNNLDAKYDQIICDGTQISYDVVTRLIEQGHRKIAYIGETQNENRYVGYCSALTDADISVSPKYVSNIVHSTEEGYKGVCHLLKSGCDATAFFCADDITAIGAMKAIKEYGLRIPEDVSVASIDDIDTAQYLIPSLTTAHIPLDEMGKMAAKILIDRIEGGHEKHLKILFPYDIIERKSTAAFRKIHGNPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CHA9</accession>
    <name>A0A174CHA9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Teichoic acids export ATP-binding protein TagH</fullName>
            <ecNumber evidence="6">3.6.3.40</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tagH_2</name>
        <name evidence="6" type="ORF">ERS852478_01916</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.40" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703540.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12307">
        <property type="protein sequence ID" value="CUO12307"/>
        <property type="gene ID" value="ERS852478_01916"/>
    </dbReference>
    <dbReference type="GeneID" id="66493878"/>
    <dbReference type="eggNOG" id="COG1134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="29"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="63"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO12307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="246" mass="27481" checksum="5806EF4277EABBC9" modified="2016-09-07" version="1">MSKQPAIIVDNVSMKFNLSKEKVDSLKDYIIKSIKKEIKYNEFWALQNVSFTVEKGDRVGILGLNGAGKSTLLKVIAGVFKPTEGSVTKHGKMVPLLELGAGFDQQYTGKENIYLYGAMLGYSKEFIDEKYDEIVKFSELKDFIDVPIKNYSSGMKSRLGFSIATVVSPKILILDEVLSVGDAKFRKKSEKKVLSMFDSGVTVLFVSHSLAQVQRICNKAMILEKGKLIAYGDIDTISEQYEKMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CJU1</accession>
    <name>A0A174CJU1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Galactose-1-phosphate uridylyltransferase</fullName>
            <shortName evidence="10">Gal-1-P uridylyltransferase</shortName>
            <ecNumber evidence="10">2.7.7.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">UDP-glucose--hexose-1-phosphate uridylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">galT_2</name>
        <name evidence="10" type="synonym">galT</name>
        <name evidence="14" type="ORF">BWLFYP14_02182</name>
        <name evidence="13" type="ORF">ERS852478_01951</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 15">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703588.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13503">
        <property type="protein sequence ID" value="CUO13503"/>
        <property type="gene ID" value="ERS852478_01951"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00571">
        <property type="entry name" value="GalP_UDP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000766">
        <property type="entry name" value="GalP_uridyl_Trfase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023425">
        <property type="entry name" value="GalP_uridyl_Trfase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39191">
        <property type="entry name" value="PTHR39191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006005">
        <property type="entry name" value="GalT_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01239">
        <property type="entry name" value="galT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01163">
        <property type="entry name" value="GAL_P_UDP_TRANSF_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 10 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="11">
        <location>
            <begin position="63"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="12">
        <location>
            <begin position="245"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO13503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX65817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="496" mass="57165" checksum="3E693883E955FB80" modified="2016-09-07" version="1">MLSESIAKLVQYGITTGLTPECERNYTTNLLLDVFHEDDYEKPDNIEESVNLEATLGELLDEAVKRGLIEDSIVYRDLFDTRLMNCLMPRPGQVQKEFWDKYKESPKEATDYFYKLSQDSNYIRRYRVEKDQKWKVDSPYGEIDITINLSKPEKDPKAIAAARNVKSGSYPKCLLCPENEGYAGRVNHPARQNHRIIPITINDTPWGFQYSPYVYYNEHCIVFNCQHTPMKIERNAFIKLFDFVKLFPHYFLGSNADLPIVGGSILSHDHFQGGHYTFAMAKAPIEQHVVLSGFEDVEAGIVKWPLSVLRIRHKDSNRLVDLATHVLEVWRGYTDEAAFIYAETNGEPHNTITPIARKVGDIYELDLTLRNNITTEEHPLGVYHPHAEYHHIKKENIGLIEVMGLAVLPARLKGEMELLEEYILEGKDISSNEQIEKHAEWVKKFLPKYPEITKENIHGILQKEIGIVFTHVLEDAGVYKCTTEGREAFMRFLETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D202</accession>
    <name>A0A174D202_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphopentomutase</fullName>
            <ecNumber evidence="4">5.4.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Phosphodeoxyribomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">deoB</name>
        <name evidence="6" type="ORF">ERS852478_02104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphotransfer between the C1 and C5 carbon atoms of pentose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27658"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-ribose 1-phosphate = D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:18793"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="5.4.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 1 or 2 manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphopentomutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.7" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200562.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19681">
        <property type="protein sequence ID" value="CUO19681"/>
        <property type="gene ID" value="ERS852478_02104"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043094">
        <property type="term" value="P:cellular metabolic compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16009">
        <property type="entry name" value="PPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00740">
        <property type="entry name" value="Phosphopentomut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010045">
        <property type="entry name" value="DeoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024052">
        <property type="entry name" value="Phosphopentomutase_DeoB_cap_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21110">
        <property type="entry name" value="PTHR21110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001491">
        <property type="entry name" value="Ppentomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143856">
        <property type="entry name" value="SSF143856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01696">
        <property type="entry name" value="deoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="5">
        <location>
            <begin position="6"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO19681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="396" mass="44178" checksum="7AD991F3A37CCAC5" modified="2016-09-07" version="1">MKNYDRIFVIVLDSLGIGAMPDSAKFGDIGVDTFGHILEKMGSLEIPNLRKLGMLNLHPAGKMAGVENPKGRYTHLGEASNGKDTMTGHWEMMGIKTEKPFKTFTETGFPPELIAELEKRCGKRVIGNKIASGTEIIEELGEEEIQTGAMIVYTSADSVLQICGNEETFDLQNLYRCCEIAREITMKDEWRVGRVIARPYIGKKKGEFKRTSNRHDYALKPTGLTTLNVLKDHGFDVIGVGKIHDIFCGEGITETYHSDSSVHGMEQTIEICKRDFRGLCFVNLVDFDALWGHRRNVEGYGKEIEKFDKNLGVLLEEMRENDLLILTADHGNDPTYTGTDHTREYVPFIAYSKRMKNGGAIKDEDTFAVIGASVAENFGVPMPEGTIGHSVLKELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DAA9</accession>
    <name>A0A174DAA9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ppaC</name>
        <name evidence="10" type="ORF">ERS852478_02197</name>
        <name evidence="12" type="ORF">GT712_11335</name>
        <name evidence="11" type="ORF">GT728_11175</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">BIOML-A1</strain>
            <strain evidence="12 14">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000025">
        <property type="protein sequence ID" value="MZL33743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707993.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22571">
        <property type="protein sequence ID" value="CUO22571"/>
        <property type="gene ID" value="ERS852478_02197"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="76"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="255"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO22571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL33743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS89648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="556" mass="62662" checksum="95B44D502906D1A5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DP62</accession>
    <name>A0A174DP62_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO27381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381069.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27381">
        <property type="protein sequence ID" value="CUO27381"/>
        <property type="gene ID" value="ERS852478_02338"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="24"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO27381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="169" mass="19371" checksum="3A725CCD824F629D" modified="2016-09-07" version="1">MSFREVKAEELTMNPFTKIGKEWLLITAGNEEKCNTMTASWGAMGVMWGKNAVTVYIRPQRYTKEFVDREDTFTISVLGEKHRKALNYCGKVSGKNADNKIKEAGLTPYFTDGTAGIEEADMIMVCKKMYHDEIKPECFDAGENDGKWYPQKDYHTMYIAEILKVLVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DYR4</accession>
    <name>A0A174DYR4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO30357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO30357">
        <property type="protein sequence ID" value="CUO30357"/>
        <property type="gene ID" value="ERS852478_02412"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZM6Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO30357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="274" mass="30101" checksum="8A56A70AC1BD2E3B" modified="2016-09-07" version="1">MKIMKILKKAGGILLVIIGILFFVSALKMIFVDNPKTKAALKDAVYVDAADTIDPENDGKTVIVCGTFELTKPAHDDELGLDFDSIRISSSKQTMKLTKSSSKKKEAMTDDEKKYGVLEWNSSFSSMPVSGQGKIGNYALSQDFIDDIMLTKTWEDYDKAALSSAGYTYVPDNTYTQKHFIEPSNQTTRSHKEYDVRYYYSAADFETGQTVTAIGIQDGQTLKSAPGITENLMKNKLDRDEAIKQGGTPGVGAQIFSVVSSLLLILGGFLLIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DYT2</accession>
    <name>A0A174DYT2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200738.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29398">
        <property type="protein sequence ID" value="CUO29398"/>
        <property type="gene ID" value="ERS852478_02381"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO29398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="262" mass="29630" checksum="9C2DC25F6C614BF2" modified="2016-09-07" version="1">MKANSGLKKNRTKIQMVLTALVILSVVRQFFLGNYHNMFLGILTLILFMVPQFLDRKLNVTIPPGLETVILIFIFSAEILGEINAFYVKIPIWDTILHTTNGFLMAAIGFALIDLFNRSDRFSIKMSPYFVAFFAFCFSMTVGVMWEFFEFSMDWFFGMDMQKDWIVPAINSVKLNPTGANVPIHVDVQSLVVNGETWDLGGYLDIGIVDTMKDLIVNFIGAIVFSVIGILYLRNRGKGKLAASLIPQVRSKQEEELSSKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E5I1</accession>
    <name>A0A174E5I1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF4179 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02489</name>
        <name evidence="4" type="ORF">GT712_02420</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000003">
        <property type="protein sequence ID" value="MZS87976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059635.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO33041">
        <property type="protein sequence ID" value="CUO33041"/>
        <property type="gene ID" value="ERS852478_02489"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025436">
        <property type="entry name" value="DUF4179"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13786">
        <property type="entry name" value="DUF4179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4179" evidence="2">
        <location>
            <begin position="40"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO33041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS87976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="368" mass="42145" checksum="A99188CA31B3B9AC" modified="2016-09-07" version="1">MLENKWNNIAPEVPQDFHEKFEETLRHIEQADAVNKKYKRKRISGRLLIAAAVICTGMGVTVAAKEFFKWNDHLLKRLEPSEKQQETMQESTYIQNINQSVTQNGVTVTLTDSIQDQGFLYAFFEVETDDNIPMTDHTSFEEMAHFKIDGKEVYAVDDNRFGSFNTGVGQDMLLKTDQNSTHLKYFNACISYDGDYDLSNKTVEITLKNLTEEGDYDTTVITDGTWDFKWTLGAVNLPTTLEVNRKCNFGGYEITVKKMEVTPLLWSLYLDYDEAMKVYEDEKNKFEYTGTDYGMDLYGRANIDQVRYKDGTVLTLDLTMGGIAGGGEKQDKENGVMIIRNSFPQLVDVDNLQAVHFGNIDQWLEVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E7E8</accession>
    <name>A0A174E7E8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_02157</name>
        <name evidence="1" type="ORF">ERS852478_02463</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32349">
        <property type="protein sequence ID" value="CUO32349"/>
        <property type="gene ID" value="ERS852478_02463"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO32349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX65788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="153" mass="17152" checksum="17BA1D193C476912" modified="2016-09-07" version="1">MKSSIVEIIYSEAQRTGKPVFCIVDDTIASKTKPSSQALHPIEDAYFLCDCGYVSEKMINTFVQKGFHTIGALKTNRLLYPSGMKKKLSELAAGLSVTEKVFDLVTVKKRKYYVYRYEGNLNGIENAVVLLSYPEKAFGNPKAPEGLAKFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EGE5</accession>
    <name>A0A174EGE5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200793.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPC010000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35499">
        <property type="protein sequence ID" value="CUO35499"/>
        <property type="gene ID" value="ERS852478_02562"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin_2" evidence="2">
        <location>
            <begin position="160"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO35499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="255" mass="28335" checksum="EF5E01E1AF93C2C8" modified="2016-09-07" version="1">MGKIVQTAGRNTLGEFAPEFAHFNDDVLFGENWNNQDIDVKTRSIITVVALMASGITDSSLKYHLQNAKNHGVTQKEIAAVITHAAFYAGWPKAWAVFNLAKEVWETGEGDLPYEEEAMRAHAKEMVFPIGEPNDGFAQYFSGRSFLAPISTSQVGIFNVTFEPGCRNNWHIHHAKSGGGQILVCVAGRGYYQEEGKDAVEMKPGDCINIPAEVKHWHGAAPDEWFSHLAIEVPGENSSNEWLEPVSDEEYRKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EHQ3</accession>
    <name>A0A174EHQ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyphosphate:AMP phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO37221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200806.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37221">
        <property type="protein sequence ID" value="CUO37221"/>
        <property type="gene ID" value="ERS852478_02622"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043751">
        <property type="term" value="F:polyphosphate:AMP phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022489">
        <property type="entry name" value="PolyP_AMP_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03708">
        <property type="entry name" value="poly_P_AMP_trns"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="PPK2" evidence="1">
        <location>
            <begin position="266"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO37221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="492" mass="58585" checksum="50EC8945AEEBA0AB" modified="2016-09-07" version="1">MLTTWTPAHMPEKEEIKTRLQTARSQLYDFQMKIKEHKIPVIVLFEGWGSSGKGSTIGKVIKNIDPRFFKVATMSAPTAEELRYPFLYRYFKQIPEAGKFTFLDSGWMEQTCKDCLSGEIEGEGYTQRIDSIRRFERQLTDNGYLVLKFFMQIDRDEQKRREKLLLDHKDTRWRVSDFDKWQNEHYKKCAKVFSQYLSDTNASSAPWYIIDASDRKWAELQVLETMVSNIEVAMQNQAHSVPILQNVFPLEQIPRLSDIDLRDKTMDDEEYRGELKQLQSKLGELHNKLYRRRIPVIITYEGWDAAGKGGNIKRITEALDPRGYEVHPIASPEPHEKARHYLWRFWTRLPKNGHIAIFDRTWYGRVMVERLEGFCSENDWKRAYNEMNEFEKELKDWGAVIIKFWVQIDKDTQLERFQERQNNPEKQWKITDEDWRNREKWDAYEVAVNEMLQKTNTSFAPWHVLESVDKKYARIKALRIVIDEIEKALKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EII9</accession>
    <name>A0A174EII9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA family ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Cell division inhibitor MinD</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Septum site-determining protein MinD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">minD_4</name>
        <name evidence="3" type="synonym">minD_2</name>
        <name evidence="6" type="ORF">BWLFYP14_02454</name>
        <name evidence="2" type="ORF">ERS852478_02586</name>
        <name evidence="3" type="ORF">ERS852523_00183</name>
        <name evidence="5" type="ORF">GT712_07305</name>
        <name evidence="4" type="ORF">GT728_02675</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000002">
        <property type="protein sequence ID" value="CUO99628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000011">
        <property type="protein sequence ID" value="MZS88877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000050">
        <property type="protein sequence ID" value="VUX66082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703890.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000003_gene1600"/>
    <dbReference type="EnsemblBacteria" id="CUO36249">
        <property type="protein sequence ID" value="CUO36249"/>
        <property type="gene ID" value="ERS852478_02586"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99628">
        <property type="protein sequence ID" value="CUO99628"/>
        <property type="gene ID" value="ERS852523_00183"/>
    </dbReference>
    <dbReference type="GeneID" id="66494127"/>
    <dbReference type="eggNOG" id="COG3640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014433">
        <property type="entry name" value="CooC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005647">
        <property type="entry name" value="CooC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO36249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO99628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="256" mass="27784" checksum="AF9FB1C186550025" modified="2016-09-07" version="1">MAHVIAVAGKGGVGKTTLCGMLIQYLCEKGKGPILAVDADANSNLNEVLGVKVETTLGDVREEIARAELAKENPIPTGMSKADYAEMRFEDALVEDDDFDLLVMGRTQGKGCYCYVNGLLQTQLAKYQNNYPYIVVDNEAGMEHISRGVLPSMQTAILVSDCSRRGVQAVGRIAELIKECDMHPDTVGLIINRAPKGELNKGIQEEIANQGLTLLGVVPQDETVYEYDCEGRPTSTLPEDNPVKTALRAIVDNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EIV9</accession>
    <name>A0A174EIV9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">map_2</name>
        <name evidence="2" type="synonym">map</name>
        <name evidence="5" type="ORF">ERS852478_02601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059582.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36638">
        <property type="protein sequence ID" value="CUO36638"/>
        <property type="gene ID" value="ERS852478_02601"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="54"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO36638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="291" mass="32599" checksum="EF0C19B81DEECF35" modified="2016-09-07" version="1">MSLKIGRNDPCWCGSGKKYKKCHEAFDEKMEIMKQKGYAVINHDLIKTPEQIAKIKESCKINIAVLDYVEEHIKPGVSTEEIDRWVHEETVRHGGIPAPLNYEGFPKSVCTSVNEVVCHGIPDEEQILKEGDIINVDVSTIYNGYYSDSSRMFCIGKVSPEKEKLVKVTKECVEIGISQVKPWTPIGNMGSAVHKHAVENGYSVVREIGGHGVGVEFHEDPWVSFVSEENTGVLMVPGMMFTIEPMVNMGSDEIYTDEIDEWTVRTEDGLPSAQWEVTVLVTETGCEVICW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EPG0</accession>
    <name>A0A174EPG0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA polymerase III</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_00892</name>
        <name evidence="2" type="ORF">ERS852478_02629</name>
        <name evidence="3" type="ORF">ERS852523_02320</name>
        <name evidence="5" type="ORF">GT712_05135</name>
        <name evidence="4" type="ORF">GT728_06760</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO37850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000023">
        <property type="protein sequence ID" value="CUP64732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000012">
        <property type="protein sequence ID" value="MZL32910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000007">
        <property type="protein sequence ID" value="MZS88487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707772.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000055_gene1916"/>
    <dbReference type="EnsemblBacteria" id="CUO37850">
        <property type="protein sequence ID" value="CUO37850"/>
        <property type="gene ID" value="ERS852478_02629"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP64732">
        <property type="protein sequence ID" value="CUP64732"/>
        <property type="gene ID" value="ERS852523_02320"/>
    </dbReference>
    <dbReference type="GeneID" id="66492724"/>
    <dbReference type="eggNOG" id="COG5018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="2"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO37850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP64732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX63414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="319" mass="38328" checksum="2AE304C0B39F71C9" modified="2016-09-07" version="1">MNYIVFDLEWNQNPSGKKTRNDRLPFEIIEIGAVKVNSKKEITDHFHRLIKPQVYKWIHDSIHEVIHVDYKDLMKGVPFEQAVREFIDWCGEDWYFFTWGNQDVMELQRNMKFYGLLDLLPGPVTYYDVQKLYSISYDDGTHRCALEHAIDELKIEKSRGFHRALADAWYTAKVLEKINNIIIINHPSLDVYQNPKKKKDEIHISYPDHDKYVSREFATRERIMKDREVTSTRCPVCHLPAKRKLRWFMNNPKVYYSISNCEEHGLIRGKIRIRKTEDEKYFAVKTLRFTDTEEAEELRERKEVLRLRRKLKRSVEKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EVJ5</accession>
    <name>A0A174EVJ5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40698">
        <property type="protein sequence ID" value="CUO40698"/>
        <property type="gene ID" value="ERS852478_02717"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013378">
        <property type="entry name" value="Listeria/Bacterioides_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042229">
        <property type="entry name" value="Listeria/Bacterioides_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09479">
        <property type="entry name" value="Flg_new"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021077" evidence="1">
        <location>
            <begin position="37"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO40698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="366" mass="41739" checksum="3399974F35326FB8" modified="2016-09-07" version="1">MRNRIIQVRHYSRKMMIMMLTGAICCSSCFCETAFAKTSKVRVYDVEKGTTGFTSFTYSDNKKDESLAPSEGAEAISSASQKVVIFHQADGSTIIRKADNNGKVTLPAIRNQTGYTFLGWSTKPDQTQNPQYQAGQVIQVRKKTHLYAVMYNWQQEPDIQVNNLAAQLSEYSGIIFVGDSRTYFMQKTLLREYGKDAVAKVSFVCKTGEGLSWFETAGERVMRSEIARLQSDSDKPVAVIFNLGVNDLSSHNSGNGVDYKGEANAYLARMNTLAEELESDCRLFYMSVNPVNTAMKPTRKEAQLRYFNDRLQSRLNKRFQWIDTYKYLMKNGYSTYNEFKGNIDDGVHYSTCTYKRIYKYCMNAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EYB0</accession>
    <name>A0A174EYB0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">S8 family serine peptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Subtilase family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Type VII secretion-associated serine protease mycosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BWLFYP14_00555</name>
        <name evidence="6" type="ORF">ERS852478_02747</name>
        <name evidence="7" type="ORF">ERS852523_02512</name>
        <name evidence="9" type="ORF">GT712_09905</name>
        <name evidence="8" type="ORF">GT728_09640</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000027">
        <property type="protein sequence ID" value="CUP70238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000019">
        <property type="protein sequence ID" value="MZL33454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000017">
        <property type="protein sequence ID" value="MZS89376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380550.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000039_gene3299"/>
    <dbReference type="EnsemblBacteria" id="CUO41516">
        <property type="protein sequence ID" value="CUO41516"/>
        <property type="gene ID" value="ERS852478_02747"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP70238">
        <property type="protein sequence ID" value="CUP70238"/>
        <property type="gene ID" value="ERS852523_02512"/>
    </dbReference>
    <dbReference type="GeneID" id="66493302"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07478">
        <property type="entry name" value="Peptidases_S8_CspA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034045">
        <property type="entry name" value="Pep_S8_CspA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017310">
        <property type="entry name" value="Pept_S8A_subtilisin_clostridia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037894">
        <property type="entry name" value="Subtilisin_rel_CspABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="108"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="442"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO41516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP70238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL33454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX62777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="573" mass="62745" checksum="2CDE350D3C6C4112" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F3U9</accession>
    <name>A0A174F3U9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotidyltransferase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02854</name>
        <name evidence="3" type="ORF">GT728_14430</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000038">
        <property type="protein sequence ID" value="MZL34363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380562.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45032">
        <property type="protein sequence ID" value="CUO45032"/>
        <property type="gene ID" value="ERS852478_02854"/>
    </dbReference>
    <dbReference type="GeneID" id="66494759"/>
    <dbReference type="eggNOG" id="COG1209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO45032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="308" mass="34890" checksum="73BF92397110C8A5" modified="2016-09-07" version="1">MKKPVLVVMAAGMGSRYGGLKQIDPVDKEGHIIMDFSIYDAVQAGFQKVVFIIKKENEADFRSAIGDRLSNQLEVSYVFQDLHNIPEGYEVPEGRVKPWGTGHAVLSCINEIDGPFVVINADDYYGSHAFKMAYDFLTENEDTADTYRYMMVGYKLENTLTENGHVARGVCVTDEEGHLLKINERTHIEKHDGGTAYTEDDGKTWTMLPEGSTVSMNMWGFSASILKELKDRFPKFLDENLKVNPLKCEYFLPFVVDELLGEKRATVKVLKSMDKWYGVTYKEDKPVVVAAIQNLKDGGLYPQKLWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F4T9</accession>
    <name>A0A174F4T9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfate/thiosulfate import ATP-binding protein CysA</fullName>
            <ecNumber evidence="6">3.6.3.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cysA_2</name>
        <name evidence="6" type="ORF">ERS852478_02816</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.25" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200943.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43769">
        <property type="protein sequence ID" value="CUO43769"/>
        <property type="gene ID" value="ERS852478_02816"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO43769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="352" mass="39248" checksum="E4FD92CF5E24B5D1" modified="2016-09-07" version="1">MYVELKNINKTYGSYQASRNVNFGIEKGKLIGLLGPSGSGKTTILRMIAGLETPDSGEVIIDGKVVNDVPSSQRGIGFVFQNYALFRYMTVYDNVAFGLKVQKADKKKIDARVRELIKLVGLEGLEKRYPSQLSGGQRQRVAFARALAPNPQVLLLDEPFAAIDAKIRQELRSWLKEMIGKLGITSIFVTHDQDEAIEVADEIIITNAGRIEQKGTPIGVYRNPETAFTASFFGQPSVLKNADDFHTFAQAEGADKIIVRPEFVKISKLDEVEKFKTSVSRGVVERVSFRGDNLELQVRVNNSVVTARRSLEKADIREGETVNVFLYRIFALRGDSVQLIENEAVRDDFVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F869</accession>
    <name>A0A174F869_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">sn-glycerol-3-phosphate import ATP-binding protein UgpC</fullName>
            <ecNumber evidence="6">3.6.3.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ugpC_2</name>
        <name evidence="6" type="ORF">ERS852478_02848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.20" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200964.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44879">
        <property type="protein sequence ID" value="CUO44879"/>
        <property type="gene ID" value="ERS852478_02848"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO44879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="377" mass="42421" checksum="33298F4361009B3C" modified="2016-09-07" version="1">MSEIILRDICKSYENGFHAVKNFNLEIEKGELVVFVGPSGCGKSTTLRMIAGLEDISDGELWIGDKLVNYLEPKERDLAMVFQSYALYPQMNIYDNIAFSLQVRKVPKKEIDKRVHHVAELLGLENLLKQRPKNLSGGQRQRVAIGNAIIREPKVLLMDEPLSNLDAKLRTQMRVELAGIHKALGNTIIYVTHDQTEAMTLGDRIVVMNQGAVQQADTPQNLYAYPVNRFVAGFIGSPSMNFIKGLAMEKVGIPTFRTENDGDIPIPDFLWKILKRQGYVGRNIELGIRPEHFLEKPAEADTRGEWKMEVTVTARELLGAEVILHFNHDGQDCCAKVSGDSLLDKGDKVTLWIDMAYISAFDLETQENITLRKGMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FCL5</accession>
    <name>A0A174FCL5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PP2C-family Ser/Thr phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pstP</name>
        <name evidence="3" type="ORF">BWLFYP14_03384</name>
        <name evidence="2" type="ORF">ERS852478_02931</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47317">
        <property type="protein sequence ID" value="CUO47317"/>
        <property type="gene ID" value="ERS852478_02931"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0631">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO47317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX67107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="272" mass="30541" checksum="6D62CC2E303B1620" modified="2016-09-07" version="1">MAMYQIECAYTCHTGNIRANNEDNFWCFGESLPVNNEGTKGICSKIISGNRVPAMAVFDGMGGESCGEIAAFLASEEFGKFYNANKRMLRDMPEDFIDDVCEKMNQAVCRYGTEHHIWSMGSTMAMLLFTPESMFACNLGDSRIYFMDGGKLQQISTDHVFGGTAVGKAPLTQYLGLPEELQRLEPSVTEIEHKEGYRYLLCSDGVTDMLSDSEIEAILSQDMEIPEIVNDLLKNALQKGGRDNVTIVLCEVQKLDTVRRMKEWMKNLKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FDM6</accession>
    <name>A0A174FDM6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small-conductance mechanosensitive channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mscS</name>
        <name evidence="8" type="ORF">ERS852478_02956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380017.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48254">
        <property type="protein sequence ID" value="CUO48254"/>
        <property type="gene ID" value="ERS852478_02956"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006686">
        <property type="entry name" value="MscS_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01246">
        <property type="entry name" value="UPF0003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO48254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="286" mass="31869" checksum="B1B734C3EE7EF3D2" modified="2016-09-07" version="1">MEQEIQEAKSLYYSYKQYFSDYLPALTKLGLKVVMALLVFVGGRKVIQWFVSFIKKSMERASVDKGVIQFTGSLLRIVLYILLVFSIATHFGVRESSIAALLGTAGVTVGLALQGGLANIAGGIMLLIFKPFQVGDYIIIAQQNGCEGTVYKIEICYTTLISIDNKHIVIPNGTLSGSIITNVTARDLRKLEIKVGISYDSDIKKAKAILEEILHNDEDTKDDQGMVVFVDELGESAVVMGLRVWVATEKYWPARWRLNELIKEAFDANGIEIPYNQLQVHVKKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FFC0</accession>
    <name>A0A174FFC0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6472 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02940</name>
        <name evidence="3" type="ORF">ERS852523_03115</name>
        <name evidence="4" type="ORF">GT712_01075</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000039">
        <property type="protein sequence ID" value="CUP87330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705180.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000068_gene3404"/>
    <dbReference type="EnsemblBacteria" id="CUO47526">
        <property type="protein sequence ID" value="CUO47526"/>
        <property type="gene ID" value="ERS852478_02940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP87330">
        <property type="protein sequence ID" value="CUP87330"/>
        <property type="gene ID" value="ERS852523_03115"/>
    </dbReference>
    <dbReference type="GeneID" id="66494702"/>
    <dbReference type="eggNOG" id="ENOG5033A60">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045525">
        <property type="entry name" value="DUF6472"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20076">
        <property type="entry name" value="DUF6472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6472" evidence="1">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO47526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP87330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS87716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="60" mass="7254" checksum="2EA1962CE867A869" modified="2016-09-07" version="1">MSDAVNCEYCVNYSYDDDYECYTCEINLDEDEMVKFITGNFNQCPYFKMGDEYRIVRKQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FNA2</accession>
    <name>A0A174FNA2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized GTP-binding protein YjiA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjiA_2</name>
        <name evidence="2" type="ORF">ERS852478_03051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379953.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51663">
        <property type="protein sequence ID" value="CUO51663"/>
        <property type="gene ID" value="ERS852478_03051"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="1">
        <location>
            <begin position="7"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO51663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="382" mass="42992" checksum="C7ED42D9657C24E4" modified="2016-09-07" version="1">MATKIDIISGFLGAGKTTLIKKLLKEAYADEQVVLIENEFGEIGIDGGFLKEAGIQIREMNSGCICCSLVGDFGTSLKEVVDKYHPDRILIEPSGVGKLSDVIKAVQGVQGDVDIVLNSYTTVVDAKKCKMYMRNFGEFFDNQVEYAGAIIMSRTDIIDEKKAQQAMELLRGINAKAAIITTPIEKLDGKKILEVMEKPVSLEEELMSEEEVCPECGHVHEHGEHHHHDHDHDHECGCGHDHEEHEHHHHDHDHECGCGHDHEEHEHHHHDHDHECGCGHDHHDHHHHHADEVFTSWGRETIKKYTREGLEKMLEALSASEDYGIILRAKGMLPAEDGTWIYFDMVPEETEIREGAPEYTGRLCVIGSKLKEDKLAELFGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FQU7</accession>
    <name>A0A174FQU7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Rebeccamycin O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rebM</name>
        <name evidence="2" type="ORF">ERS852478_03041</name>
        <name evidence="3" type="ORF">GT712_01585</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704955.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50989">
        <property type="protein sequence ID" value="CUO50989"/>
        <property type="gene ID" value="ERS852478_03041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="46"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO50989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS87816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="203" mass="22291" checksum="C528FE579D4BE8E6" modified="2016-09-07" version="1">MRFFENTRKPQGFGGKLMTKMMNSGHAKLSQWGFSNISAKSDAEVLDVGCGGGANIAVWLDRCRNGHVTGMDYSEVSVAESQKLNALAIKQGKCNVVQGDVSAIPFSDATFDYVSAFETVYFWPGLVKCFSEVNRVLKSEGIFLICNESDGTNAADEKWTKMINGMKIYTSKQLVAALKEAGFTEIKTYSNAKNHWISIVATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G0B6</accession>
    <name>A0A174G0B6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">clpX_2</name>
        <name evidence="6 11" type="synonym">clpX</name>
        <name evidence="10" type="ORF">ERS852478_03171</name>
        <name evidence="12" type="ORF">GT712_16130</name>
        <name evidence="11" type="ORF">GT728_16495</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 13">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">BIOML-A1</strain>
            <strain evidence="12 14">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000051">
        <property type="protein sequence ID" value="MZL34749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000041">
        <property type="protein sequence ID" value="MZS90546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705989.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO55381">
        <property type="protein sequence ID" value="CUO55381"/>
        <property type="gene ID" value="ERS852478_03171"/>
    </dbReference>
    <dbReference type="GeneID" id="66494505"/>
    <dbReference type="eggNOG" id="COG1219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ClpX-type ZB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="402"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="120"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO55381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL34749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS90546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="438" mass="48425" checksum="9E912B3E1D556B6B" modified="2016-09-07" version="1">MAEKMREGKVRCSFCQKTEDQVRKLIAGPDGKVFICDECIGICSEIMEEELNPYDDEVLNSDINLLKPEEIHAVLDDYVIGQDAAKKALSVAVYNHYKRILASKNSDVELQKSNILMLGPTGSGKTLLAQTLARLLNVPFAIADATTLTEAGYVGEDVENILLKIIQAADYDIERAQYGIIYIDEIDKITRKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQEFLQIDTTNILFICGGAFDGIEKIIESRQDTKSIGFGAEVSVKEDRNVGEILKDVMPEDFIKFGLIPEFIGRVPVVVTLDALDENALISILKEPKNSLTKQYHRLFELDGVELDFEDDALELVAKKSLERKTGARGLRAIMEGSLMDLMYKIPSDDTIRKCTITKDVVDGTGEPEIVRGETPAQAKTAGSRRTSRTHKKDKPETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GIF7</accession>
    <name>A0A174GIF7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ammonia permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_03311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO60215">
        <property type="protein sequence ID" value="CUO60215"/>
        <property type="gene ID" value="ERS852478_03311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="6">
        <location>
            <begin position="10"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO60215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="95" mass="10047" checksum="D4D1E08524B010F0" modified="2016-09-07" version="1">MEFSAVNTIWVLVGAALVFFMQAGFAMVETGFTRAKNAGNIIMKNLMDFCIGTPVFWLVGFGLMFGAGNGFIGKIGGIATEAHYGSGMLPDGVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GIN7</accession>
    <name>A0A174GIN7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HPr family phosphocarrier protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">PTS HPr component phosphorylation site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_00752</name>
        <name evidence="2" type="ORF">ERS852478_03314</name>
        <name evidence="3" type="ORF">ERS852523_00130</name>
        <name evidence="5" type="ORF">GT712_14915</name>
        <name evidence="4" type="ORF">GT728_14645</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO60295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO97669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000039">
        <property type="protein sequence ID" value="MZL34402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000034">
        <property type="protein sequence ID" value="MZS90324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000019">
        <property type="protein sequence ID" value="VUX63003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993699.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000041_gene2584"/>
    <dbReference type="EnsemblBacteria" id="CUO60295">
        <property type="protein sequence ID" value="CUO60295"/>
        <property type="gene ID" value="ERS852478_03314"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO97669">
        <property type="protein sequence ID" value="CUO97669"/>
        <property type="gene ID" value="ERS852523_00130"/>
    </dbReference>
    <dbReference type="GeneID" id="66494393"/>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="15"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO60295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO97669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX63003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="75" mass="8576" checksum="331D0F43F71B547D" modified="2016-09-07" version="1">MSQSKIKLNATEEVQEFVNAASRCDFDIDVYYNRFLIDAKSILGVLSLDLTRELTVDCHGESREFDRTLKKFAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GQB2</accession>
    <name>A0A174GQB2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaconyl-CoA decarboxylase subunit gamma</fullName>
            <ecNumber evidence="2">4.1.1.70</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gcdC</name>
        <name evidence="3" type="ORF">BWLFYP14_02976</name>
        <name evidence="2" type="ORF">ERS852478_03394</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.1.1.70" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000072">
        <property type="protein sequence ID" value="VUX66700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381146.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63049">
        <property type="protein sequence ID" value="CUO63049"/>
        <property type="gene ID" value="ERS852478_03394"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="51"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO63049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="122" mass="11775" checksum="975145812E8A7603" modified="2016-09-07" version="1">MKSYTITVNGTAYEVTVEETGSVSAPAAAPKAAPKAAPAAAPKAAAPAAGAGAVKVTASVPGKVVKVAASVGQAVKAGDSVIILESMKMEIPVVAPQDGTIASIDVAEGASVENGDTLATMN</sequence>
</entry>
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    <name>A0A174GVP6_9FIRM</name>
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        <submittedName>
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    </protein>
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        <name evidence="2" type="ORF">ERS852478_03508</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66603">
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        <property type="gene ID" value="ERS852478_03508"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="ATPase_AAA_core"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
            <begin position="471"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO66603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="674" mass="79086" checksum="681FCC8A293883AE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GVV9</accession>
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        <name evidence="5" type="ORF">GT712_16585</name>
        <name evidence="4" type="ORF">GT728_16110</name>
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    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 10">BIOML-A1</strain>
            <strain evidence="5 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000044">
        <property type="protein sequence ID" value="MZS90631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_WWVQ01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65357">
        <property type="protein sequence ID" value="CUO65357"/>
        <property type="gene ID" value="ERS852478_03469"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:glycolytic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO65357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="182" mass="19284" checksum="431CA82AD580CAA5" modified="2016-09-07" version="1">MLRYLPVRRVHARQVLDSRGNPTVEVEVTVGEGVIGINGYTGRAIVPSGASTGKFEAVELRDGEKGCYTGLGVRKAVENVNTKLAEAILGENALDQSYIDKKIIETDGTDNKSNVGANAALGVSLAVARAAAAALRVPLYQYLGGCHTRQMPVPMMNILNGGACVIIMTQGRTPYNTRALAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GX51</accession>
    <name>A0A174GX51_9FIRM</name>
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        <submittedName>
            <fullName evidence="4">GNAT family N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_01592</name>
        <name evidence="3" type="ORF">ERS852478_03532</name>
        <name evidence="4" type="ORF">GT712_09190</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705621.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67302">
        <property type="protein sequence ID" value="CUO67302"/>
        <property type="gene ID" value="ERS852478_03532"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025685">
        <property type="entry name" value="YoaP-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14268">
        <property type="entry name" value="YoaP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="YoaP" evidence="2">
        <location>
            <begin position="201"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO67302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="248" mass="28368" checksum="8BD943B91DCBF11B" modified="2016-09-07" version="1">MEYIRVTKENLEKEHICCAISNNKDIQVSSKKAWLADRFDEGLVFLKSVERGKCFIEYIPAECAWNPIEAPGYMYINCLWVSGSFKGHGYSSDLLSECIEDSKEKGKKGLCILAAARKKPFLADSKFLKYKGFKACDEADNGIQLWYLPFEEKTEPPVFKECAKHHHINESGYVLYYTNQCPFNAKYVPILEETAQKNGIPLKAVKIENRKDAQNVPTPITTYALFCDGEYVTNEQMNDKKFLKLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GX98</accession>
    <name>A0A174GX98_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hef nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67224">
        <property type="protein sequence ID" value="CUO67224"/>
        <property type="gene ID" value="ERS852478_03529"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="467"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO67224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="990" mass="113688" checksum="8E6ECC90EF4A41FA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GXK2</accession>
    <name>A0A174GXK2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIR2_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66681">
        <property type="protein sequence ID" value="CUO66681"/>
        <property type="gene ID" value="ERS852478_03511"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039444">
        <property type="entry name" value="SIR2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13289">
        <property type="entry name" value="SIR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIR2_2" evidence="1">
        <location>
            <begin position="81"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO66681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="258" mass="30210" checksum="207E000AB4C9386A" modified="2016-09-07" version="1">MNCGGIFLIDVSKKSFDSEFPKKIWKRIEAGEYECAASDVLEELGEGEFYSALTDAFSKEKIKTVKNMAVNLLPDIFHGFVITTNYDRILEKVYRDNNNSFEEVSYHIDESDRMNELWTRGNAENRHYLFKIHGDIETERSLVLTEEKYKEKYAPGTIFRIALETIFRNKSFLFLGCSLKGDRTIQLYKEIKKESKLYGYAFVQKPTDEKEAQKRARELSNMLIHPIWYPKTDVKHESVKVLLRYIGKQVNQVKKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H270</accession>
    <name>A0A174H270_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060661.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66915">
        <property type="protein sequence ID" value="CUO66915"/>
        <property type="gene ID" value="ERS852478_03520"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO66915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="123" mass="14750" checksum="2E7052CD8AB14C2D" modified="2016-09-07" version="1">MKFRKNVPAEHREFLQEQLKQYKKEMTMTKNELRELEKWVASGRSPYDNGDYIYSENGCPMDFVSAMRFQDEIYEWWMSLSEEEQEQELRELRGDYDTVSDSIIINTEWSDPAMDPDAELPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H3L8</accession>
    <name>A0A174H3L8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter YfdV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_03604</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201463.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69443">
        <property type="protein sequence ID" value="CUO69443"/>
        <property type="gene ID" value="ERS852478_03604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO69443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="311" mass="34844" checksum="AF937DDF7A384E47" modified="2016-09-07" version="1">MNTFSILTAQIGMFVIYMIAGVILIRTRVMNRENLEVISKFVIKLALPVMIFINTVNGVERKTLFHSLSIFLIAGIMYICLFLLSYISGIFFHLHGNHRQLYSAMSVFGNVGFMGIPIVTSIYPENGMLYICVFTIIDQLMLWTAGVRLTSGTNSQKNRFDFRKLINPVTVSIFLAVICVLTGIRLPEVLNNSLQKIGQTATPLAMIYLGGVFACIDVLKNIRRLDYYGIVILKMLLFPLFFYVLLGYLPVSSEIRTTMALTSAMPVMSSVVMMANAYGSDGDYAMGGILVTTICSVFTLPFIYWIFHFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H5Y4</accession>
    <name>A0A174H5Y4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Macrolide export ATP-binding/permease protein MacB</fullName>
            <ecNumber evidence="2">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">macB_8</name>
        <name evidence="2" type="ORF">ERS852478_03579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO68827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68827">
        <property type="protein sequence ID" value="CUO68827"/>
        <property type="gene ID" value="ERS852478_03579"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="16"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO68827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="147" mass="16029" checksum="9600C8DEEBAD771B" modified="2016-09-07" version="1">MALTINKVPAGEIDGRVREMAGKLNITDILDKYPYQVSGGQKQRCACARAIINQPKLILADEPTGALDSHSSQALLSTIQSINESLDATILMVTHDAFSASYANRILFLRDGAIFTEILKGSDSRRVFFEKILDVLTMMGGGVNDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H9A2</accession>
    <name>A0A174H9A2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_009244013.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71522">
        <property type="protein sequence ID" value="CUO71522"/>
        <property type="gene ID" value="ERS852478_03672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="65" mass="7405" checksum="E760FA0DC7AB01D8" modified="2016-09-07" version="1">MSIVQEKMYMDVDDVCAILGVSKAYAYNLMREYNKELKAKGYIVVAGKISTKFLAEKIYGMKVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HEI2</accession>
    <name>A0A174HEI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03673</name>
        <name evidence="2" type="ORF">GT712_06820</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000010">
        <property type="protein sequence ID" value="MZS88789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201484.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000072.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71540">
        <property type="protein sequence ID" value="CUO71540"/>
        <property type="gene ID" value="ERS852478_03673"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO71540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS88789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="72" mass="8523" checksum="97C23B549F661288" modified="2016-09-07" version="1">MRKRKMYLSVEDIAELFGLSVSFAYRVVERMNADLASKNYYVILGRVPTRYVEDKIYGLEHVEQYLKEDKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HNS7</accession>
    <name>A0A174HNS7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000058">
        <property type="protein sequence ID" value="CUO76603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO76603">
        <property type="protein sequence ID" value="CUO76603"/>
        <property type="gene ID" value="ERS852478_03834"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033VBS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO76603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="439" mass="49593" checksum="5F7FCD75D0E175AC" modified="2016-09-07" version="1">MRYEKYEATVSSEILDLGQTGVNGSGWGWERLEIKNTGTEAWHIKSISELNDFTLEPFDYPFQGRFPMEVGNKVKPGEAVAADIYVKKNLSPGIHEETFVMETEEGIQAKCRIRVLIRGASDQDYEVNCRPNSGTRFLTITPEEYDWWDNTDPDPDMFMCPKRSIWIYNNGKNPVTVDFENTEHFWAYLDDYETGVIMPGEGTTVYLRPKKEEQVATDIFKVSITGGIELSYIISQNCPHIAPPYPEGATIKDVKVQGSTIKAAAYDCANSEGFDAVLTKKSWVDRPENYVKVAKNQDAKTITFTNVKNGTYYLGIHAYNRDYYDGNVSGKRFGAWSYPVKVVVKNGIPTERVKIKTVKTSKGAVAVTVGVPKGFARADMELRSTGGTTVYKRNNRTTYTRITGVKPGTYTLRVRPWAKTNGRKAYGDWVSWGRRIRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HP94</accession>
    <name>A0A174HP94_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP pyrophosphokinase ywaC</fullName>
            <ecNumber evidence="3">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ywaC_5</name>
        <name evidence="3" type="ORF">ERS852478_03796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000050">
        <property type="protein sequence ID" value="CUO75117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75117">
        <property type="protein sequence ID" value="CUO75117"/>
        <property type="gene ID" value="ERS852478_03796"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="2">
        <location>
            <begin position="82"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO75117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="246" mass="29130" checksum="46CB90E570AC3947" modified="2016-09-07" version="1">MKNFEEIMSERKNRIEARKDELIRRSLLSEEFLEMIQKNKRPFDLLMSYYQCAVMEIETKFRVLNQEYSLEYDKNPIEGIKTRIKSYDSIVRKIRRKNIPMSLTAIEENIKDIAGVRVICSFPEDIYELADSFLRQDDIVLIEKKDYIKNPKPSGYRSLHLIVQVPIFLQKNKKMVNVEVQFRTIAMDFWASLEHKLRYKKDIPADQAQQLQEELLACATQSAQLDNRMQEIRNQLVSRADKGNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HRT2</accession>
    <name>A0A174HRT2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-6-phosphate isomerase YvyI</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">Putative mannose-6-phosphate isomerase yvyI</fullName>
            <ecNumber evidence="1 2">5.3.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yvyI</name>
        <name evidence="2" type="ORF">BWLFYP14_03466</name>
        <name evidence="1" type="ORF">ERS852478_03807</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.1.8" evidence="1 2"/>
    <dbReference type="EMBL" id="CYZN01000052">
        <property type="protein sequence ID" value="CUO75545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000081">
        <property type="protein sequence ID" value="VUX67191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75545">
        <property type="protein sequence ID" value="CUO75545"/>
        <property type="gene ID" value="ERS852478_03807"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO75545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX67191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="116" mass="13304" checksum="43BDC04E6847A75A" modified="2016-09-07" version="1">MKYLQNVPIHKDDLFFIPAGTIHAIGAGALVAEIQESSNLTYRLYDYDRIGKDGKKRELHIDKALDVADLHGSAEPRQPLRVLKYRPGMASELLIRCKYFEVYRMLINGVCQEVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JPB6</accession>
    <name>A0A174JPB6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CooT family nickel-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Predicted RNA-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Putative RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02455</name>
        <name evidence="1" type="ORF">ERS852478_02587</name>
        <name evidence="2" type="ORF">ERS852523_00184</name>
        <name evidence="4" type="ORF">GT712_07310</name>
        <name evidence="3" type="ORF">GT728_02680</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000002">
        <property type="protein sequence ID" value="CUO99657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000011">
        <property type="protein sequence ID" value="MZS88878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000050">
        <property type="protein sequence ID" value="VUX66083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703891.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000004.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000003_gene1601"/>
    <dbReference type="EnsemblBacteria" id="CUO36276">
        <property type="protein sequence ID" value="CUO36276"/>
        <property type="gene ID" value="ERS852478_02587"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO99657">
        <property type="protein sequence ID" value="CUO99657"/>
        <property type="gene ID" value="ERS852523_00184"/>
    </dbReference>
    <dbReference type="GeneID" id="66494126"/>
    <dbReference type="eggNOG" id="ENOG5034BV3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019300">
        <property type="entry name" value="CooT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10133">
        <property type="entry name" value="CooT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO36276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO99657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="60" mass="6703" checksum="129E1A3D9BECF562" modified="2016-09-07" version="1">MCLATVYKESDDSVIFKNVSRIDVDGNKLILRDIMGDERVVEGTILMVDLANSIVKLKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174N036</accession>
    <name>A0A174N036_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-destabilizing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Single-stranded DNA-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Single-stranded DNA-binding protein ssb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ssb_1</name>
        <name evidence="7" type="synonym">ssb_2</name>
        <name evidence="3" type="synonym">ssb_3</name>
        <name evidence="7" type="ORF">BWLFYP14_03571</name>
        <name evidence="3" type="ORF">ERS852478_02979</name>
        <name evidence="4" type="ORF">ERS852523_01471</name>
        <name evidence="6" type="ORF">GT712_01730</name>
        <name evidence="5" type="ORF">GT728_07435</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO49017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP39309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000013">
        <property type="protein sequence ID" value="MZL33038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000002">
        <property type="protein sequence ID" value="MZS87843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706256.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000013.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000037_gene3238"/>
    <dbReference type="EnsemblBacteria" id="CUO49017">
        <property type="protein sequence ID" value="CUO49017"/>
        <property type="gene ID" value="ERS852478_02979"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP39309">
        <property type="protein sequence ID" value="CUP39309"/>
        <property type="gene ID" value="ERS852523_01471"/>
    </dbReference>
    <dbReference type="GeneID" id="66493680"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO49017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP39309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL33038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS87843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX67296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="208" mass="24177" checksum="9B29637BE9191D9D" modified="2016-09-07" version="1">MADKIIENNQVSMMGKIAAGFTFSHQVFGEGFYMTELLVKRLSDSEDRIPVMVSERLVDVTQDYIGEYVEIHGQFRSYNRHEEKHNRLVLSVFSRELKFVEEEDETVPVNQIFLDGYICKPPVYRKTPLGREIADVLLAVNRPYGKSDYIPCICWGRNARYASAFEVGGHVLIWGRIQSREYMKRIGENETEKRVAYEVSVSKLEYME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174PB31</accession>
    <name>A0A174PB31_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pta</name>
        <name evidence="11" type="ORF">BWLFYP14_00156</name>
        <name evidence="7" type="ORF">ERS852478_02379</name>
        <name evidence="8" type="ORF">ERS852523_02020</name>
        <name evidence="10" type="ORF">GT712_04585</name>
        <name evidence="9" type="ORF">GT728_02145</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + phosphate = acetyl phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19521"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000019">
        <property type="protein sequence ID" value="CUP55878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL32034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019161337.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1108"/>
    <dbReference type="EnsemblBacteria" id="CUO29322">
        <property type="protein sequence ID" value="CUO29322"/>
        <property type="gene ID" value="ERS852478_02379"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP55878">
        <property type="protein sequence ID" value="CUP55878"/>
        <property type="gene ID" value="ERS852523_02020"/>
    </dbReference>
    <dbReference type="GeneID" id="66494267"/>
    <dbReference type="eggNOG" id="COG0280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008959">
        <property type="term" value="F:phosphate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012147">
        <property type="entry name" value="P_Ac_Bu_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004614">
        <property type="entry name" value="P_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000428">
        <property type="entry name" value="P_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00651">
        <property type="entry name" value="pta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTA_PTB" evidence="6">
        <location>
            <begin position="3"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO29322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP55878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL32034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS88388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX66603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="336" mass="35547" checksum="50CFCEBC7A74DD60" modified="2016-09-07" version="1">MGFIDTLKERAKANVKTIVLPETEDKRTLAATEKILKEGIAKVILVGNEEAVKKSAAEDGYDISGAQIVDPATSEKTQGYIDKLVELRQKKGMTPDQAKEILLNQYLYYGVMMVKMGDADGMVSGACHSTADTLRPCLQILKTKPGTKLVSAFFLMVVPNCEYGANGAFVFADSGLNQNPTSEELAAIAASSAESFELLVQEKPIVAMLSHSTKGSAKHADVDKVVEATKIAKEQNPELALDGEFQLDAAIVPSVGASKAPGSEVAGKANVLVFPDLDAGNIGYKLVQRLAKAEAYGPVTQGIAKPVNDLSRGCSADDIVGVVAITAVQCQADDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174Q5Q2</accession>
    <name>A0A174Q5Q2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 10" type="primary">rplK</name>
        <name evidence="13" type="ORF">BWLFYP14_01181</name>
        <name evidence="9" type="ORF">ERS852478_01768</name>
        <name evidence="10" type="ORF">ERS852523_02364</name>
        <name evidence="12" type="ORF">GT712_12075</name>
        <name evidence="11" type="ORF">GT728_05725</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4 6">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000024">
        <property type="protein sequence ID" value="CUP66045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000009">
        <property type="protein sequence ID" value="MZL32718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705378.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000018_gene16"/>
    <dbReference type="EnsemblBacteria" id="CUO06968">
        <property type="protein sequence ID" value="CUO06968"/>
        <property type="gene ID" value="ERS852478_01768"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP66045">
        <property type="protein sequence ID" value="CUP66045"/>
        <property type="gene ID" value="ERS852523_02364"/>
    </dbReference>
    <dbReference type="GeneID" id="66493429"/>
    <dbReference type="eggNOG" id="COG0080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="7">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO06968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP66045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL32718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS89790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX63822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="141" mass="14787" checksum="91411F42AD818C47" modified="2016-09-07" version="1">MAKKVTGYIKLQIPAGKATPAPPVGPALGQHGVNIVQFTKEFNARTADQGDLIIPVVITVYADRSFSFITKTPPAAVLLKKAAKIKSGSGVPNKTKVAKVTKAQVQEIAELKMKDLNAASLEAAMSMIAGTARSMGIEVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QW59</accession>
    <name>A0A174QW59_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03753</name>
        <name evidence="3" type="ORF">ERS852523_02663</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000047">
        <property type="protein sequence ID" value="CUO73859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000029">
        <property type="protein sequence ID" value="CUP74409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580868.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000067.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000107_gene609"/>
    <dbReference type="EnsemblBacteria" id="CUO73859">
        <property type="protein sequence ID" value="CUO73859"/>
        <property type="gene ID" value="ERS852478_03753"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP74409">
        <property type="protein sequence ID" value="CUP74409"/>
        <property type="gene ID" value="ERS852523_02663"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="1">
        <location>
            <begin position="238"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO73859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP74409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="666" mass="75763" checksum="914A56635C8F6706" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QX48</accession>
    <name>A0A174QX48_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sigK_2</name>
        <name evidence="9" type="synonym">sigK</name>
        <name evidence="9" type="ORF">ERS852478_01080</name>
        <name evidence="10" type="ORF">ERS852523_02695</name>
        <name evidence="12" type="ORF">GT712_13545</name>
        <name evidence="11" type="ORF">GT728_14215</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">2789STDY5834863</strain>
            <strain evidence="10 14">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 16">BIOML-A1</strain>
            <strain evidence="12 15">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000030">
        <property type="protein sequence ID" value="CUP75448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000037">
        <property type="protein sequence ID" value="MZL34321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000028">
        <property type="protein sequence ID" value="MZS90067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381225.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000037.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000035_gene3828"/>
    <dbReference type="EnsemblBacteria" id="CUN79420">
        <property type="protein sequence ID" value="CUN79420"/>
        <property type="gene ID" value="ERS852478_01080"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP75448">
        <property type="protein sequence ID" value="CUP75448"/>
        <property type="gene ID" value="ERS852523_02695"/>
    </dbReference>
    <dbReference type="GeneID" id="66496233"/>
    <dbReference type="eggNOG" id="COG1191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN79420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP75448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL34321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS90067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="209" mass="24114" checksum="4706D4142FA51248" modified="2016-09-07" version="1">MKAFQKPLSISQEKYYLQKYQEGDSQAKNILIEHNLRLVAHVVKKYQGTGEDTDDLISIGTIGLIKAVTTFNPQKASRLSTYAARCIENELLMYFRAKKKHSKEVSLYEPIGTDKEGNEINLLDVIESAPVDIVEDCYIRENTDYLLRSLKKVLSDKEYQVICCRYGLFGMEEETQREIARKLCISRSYVSRIEKTALQKLRGLFPQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SKK6</accession>
    <name>A0A174SKK6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0145 protein ERS852478_03274</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ybjQ</name>
        <name evidence="3" type="ORF">ERS852478_03274</name>
        <name evidence="4" type="ORF">ERS852523_03429</name>
        <name evidence="5" type="ORF">GT712_16880</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO58928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000049">
        <property type="protein sequence ID" value="CUP95975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000046">
        <property type="protein sequence ID" value="MZS90687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705112.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000055.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000069_gene2320"/>
    <dbReference type="EnsemblBacteria" id="CUO58928">
        <property type="protein sequence ID" value="CUO58928"/>
        <property type="gene ID" value="ERS852478_03274"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP95975">
        <property type="protein sequence ID" value="CUP95975"/>
        <property type="gene ID" value="ERS852523_03429"/>
    </dbReference>
    <dbReference type="GeneID" id="66495393"/>
    <dbReference type="eggNOG" id="COG0393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO58928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP95975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS90687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="103" mass="11042" checksum="9C90C1D4EBEB7205" modified="2016-09-07" version="1">MKLLSIEYIPGVEFEALGIVKGTVVQTKNVGKDFMAGMKTLVGGEITGYTEMLNEARQIATKRMVDEAKEMNADAVIGVKYGSSQVMSGAAEVIAYGTAVKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SKW3</accession>
    <name>A0A174SKW3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">proC</name>
        <name evidence="5" type="ORF">ERS852478_03177</name>
        <name evidence="6" type="ORF">ERS852523_03504</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
            <strain evidence="6 8">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000053">
        <property type="protein sequence ID" value="CUP98353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380867.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000189_gene1038"/>
    <dbReference type="EnsemblBacteria" id="CUO55582">
        <property type="protein sequence ID" value="CUO55582"/>
        <property type="gene ID" value="ERS852478_03177"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP98353">
        <property type="protein sequence ID" value="CUP98353"/>
        <property type="gene ID" value="ERS852523_03504"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="3">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="4">
        <location>
            <begin position="160"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO55582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP98353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="264" mass="28453" checksum="2D296AD3D3E4AEDB" modified="2016-09-07" version="1">MKIGFIGCGNMASAMISGMLKKGLYKKDEIIVSNLTEEGSKRSREKLGVVTTLDNHEVVKNTKLVFLAVKPQFYEEVLNEVKDELTPEHTVVGIAPGKTLAWLEEKCGQPLKVVRMMPNTPAQVGEGMTGVCANEKVSAEELAQICEITDSFGRTEVVPERLMDAVSAVSGCSPAYVFMFIEAMADAAVAQGMPRKQAYQFAAQALLGSAKMVLETGMHPGELKDMVCSPAGSTIEGVRILEQKGFRSAVFEALNGAAEKGKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174T553</accession>
    <name>A0A174T553_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03694</name>
        <name evidence="3" type="ORF">ERS852523_03758</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO72098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000063">
        <property type="protein sequence ID" value="CUQ04912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015530205.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000063.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72098">
        <property type="protein sequence ID" value="CUO72098"/>
        <property type="gene ID" value="ERS852478_03694"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ04912">
        <property type="protein sequence ID" value="CUQ04912"/>
        <property type="gene ID" value="ERS852523_03758"/>
    </dbReference>
    <dbReference type="GeneID" id="15230406"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="79"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ04912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="138" mass="16501" checksum="B0E0A84027CE4D7A" modified="2016-09-07" version="1">MKPSDFQKTVQCRFESCLKKVVRHVVKDYQKKLKRRQKEETLFCELPEIVVESLAVWDDYDTDYTIFNVCGSDIRICDDELAEALKHLSERNRENLLMYYFLEMSDTEIAKRQNISRSGVFQNRHNSLELMKKILKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WPU6</accession>
    <name>A0A173WPU6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein involved in cytokinesis, contains TGc (Transglutaminase/protease-like) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199475.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41501">
        <property type="protein sequence ID" value="CUN41501"/>
        <property type="gene ID" value="ERS852478_00028"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008014822" evidence="2">
        <location>
            <begin position="28"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="446"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN41501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="540" mass="59533" checksum="AAD7857110ED5072" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WQ16</accession>
    <name>A0A173WQ16_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Predicted AAA-ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00032</name>
        <name evidence="3" type="ORF">GT712_07745</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
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            <strain evidence="2 4">2789STDY5834863</strain>
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    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
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                <person name="Livny J."/>
                <person name="Vlamakis H."/>
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                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
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                <person name="Groussin M."/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
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    </evidence>
    <sequence length="264" mass="29708" checksum="9E142C54691AD675" modified="2016-09-07" version="1">MKYSYYPGCTLRNKAKDLDEYARASARALGFELEEIEDWQCCGGVYPLGTDEIATKLSSVRALNQAKEKGQDLVTICSACHHVIKRVNDDMKNVEDIRTRANNYMQLDEPYAGETTVLHYLEVLRDRVGFDKLKEKVVNPLTGKKIGAYYGCLLLRPGKIMAFDDPENPTIMEDFIRALGAEPVIYPYRNECCGGYISLKEKDMSQNMCQKIEDSAKGFGADMLITACPLCKYNLNKNASSELPVYYFTELLAEALGVKEEVAK</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000095431"/>
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    <sequence length="160" mass="16681" checksum="E4DDD3ACF893D742" modified="2016-09-07" version="1">MKQKTACLGLFSAVAIILGYVESLVPVFAGIPGIKLGLANLGVLFILKKYSFREAALVSVVRILVIGFMFGNLFSILYSLAGAALSMTVMTLMLKNTSFSLIGVSVAGGVSHNIGQLIIAMLIVQNASVFVYAPALLVAGVAAGVVIGGLTNEILKRVHL</sequence>
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<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WXB2</accession>
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    </evidence>
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        <source>
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<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="5 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.41"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.1.41" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000005">
        <property type="protein sequence ID" value="MZL32173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="VUX66229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993903.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000020_gene123"/>
    <dbReference type="EnsemblBacteria" id="CUN43807">
        <property type="protein sequence ID" value="CUN43807"/>
        <property type="gene ID" value="ERS852478_00103"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP52069">
        <property type="protein sequence ID" value="CUP52069"/>
        <property type="gene ID" value="ERS852523_01887"/>
    </dbReference>
    <dbReference type="GeneID" id="66495922"/>
    <dbReference type="eggNOG" id="COG1713">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005249">
        <property type="entry name" value="YqeK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TIGR00488"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN43807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP52069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL32173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS87692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="196" mass="22610" checksum="8ADFEADE6B24E47B" modified="2016-09-07" version="1">MAEYDFIKMQKKLAKYLDEDRYEHTLGVMFTCAALAMVHDCDLITAQTAGLLHDCAKCIPNKKKLKMCSQHHISVSEFEQEHPFLLHAKLGAYVAKAKYDVTDENILSAITWHTTGKPEMTLLEKIVYIADYIEPKRDKAPNLAIVRKLAFQDLDECMYKILGDTLAYLEENPKDIDNATKDAFLYYRDLHMKRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X048</accession>
    <name>A0A173X048_9FIRM</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BWLFYP14_02657</name>
        <name evidence="2" type="ORF">ERS852478_00159</name>
        <name evidence="3" type="ORF">ERS852523_00316</name>
        <name evidence="5" type="ORF">GT712_00660</name>
        <name evidence="4" type="ORF">GT728_06195</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUP03435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703215.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000032_gene398"/>
    <dbReference type="EnsemblBacteria" id="CUN45249">
        <property type="protein sequence ID" value="CUN45249"/>
        <property type="gene ID" value="ERS852478_00159"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP03435">
        <property type="protein sequence ID" value="CUP03435"/>
        <property type="gene ID" value="ERS852523_00316"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M14"/>
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        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M14" evidence="1">
        <location>
            <begin position="8"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN45249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP03435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL32807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS87637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="299" mass="34747" checksum="EC2198509925B811" modified="2016-09-07" version="1">MSTEQMGTYEKIYFALWELGQRYGNFVQFRVIGRSHDDRMIPMLEIGKGDTCIICLSGVESGDRNLPEYLLSIAKDYCRSYESNWTIGESYEVRKLLDKVRICMIPMLNPDSYEICEYGYGAIHNPIHRQMLKMQDRPVEEYECNARGIDLRRNFPTNYYQRKRVNQEPASENETRALISIFQEYSSLGLLTFSYSRGKIVYCRQEKGFAYNQKNYRLARHLQKCSGYRLEKGIAGGARVKKAGAKPEMGSPEQFYAEVIRQPSLAIEIPEYRKDDMEELRLIPLEYLYSLNSGILANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X4P0</accession>
    <name>A0A173X4P0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybaK</name>
        <name evidence="5" type="ORF">ERS852478_00212</name>
        <name evidence="6" type="ORF">ERS852523_00369</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
            <strain evidence="6 8">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CUP04711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000025_gene945"/>
    <dbReference type="EnsemblBacteria" id="CUN46711">
        <property type="protein sequence ID" value="CUN46711"/>
        <property type="gene ID" value="ERS852478_00212"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04711">
        <property type="protein sequence ID" value="CUP04711"/>
        <property type="gene ID" value="ERS852523_00369"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="48"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN46711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP04711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="172" mass="19092" checksum="ED9BC248710AF34A" modified="2016-09-07" version="1">MPEDRKDRREKMAKEAKTNAMRMLDRQKVKYEAFSYECDEFIDGIHSADKIGAPYDQSFKTLVMEGKSGGYFVFVVPIEKEVDRKAAAKAVGEKTVDMIHVKDITKITGYVRGGCSPLGMKKPYPVVFDASAGEFEEIYVSGGRIGLTLKVPLADLLKVTGGKLADIIMKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X7G1</accession>
    <name>A0A173X7G1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_02740</name>
        <name evidence="1" type="ORF">ERS852478_00244</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN47583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703348.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN47583">
        <property type="protein sequence ID" value="CUN47583"/>
        <property type="gene ID" value="ERS852478_00244"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50324Z7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046313">
        <property type="entry name" value="DUF6465"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20069">
        <property type="entry name" value="DUF6465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN47583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX66366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="143" mass="15714" checksum="F549E1DEA5E9064D" modified="2016-09-07" version="1">MRKRTTSRAKETIKEATTKATEAVKETVEKTTVKASEVIEEAKDAAADIAKAPVVEEAKETVKKAVKEVAKNIDIKKFAETTIELPGFAVTMSSIEEAIKKDIKDKGIEGKEISVYVNVEQKAAYYTVDGQGSDDYRIDLNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XHG4</accession>
    <name>A0A173XHG4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN50075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199552.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN50075">
        <property type="protein sequence ID" value="CUN50075"/>
        <property type="gene ID" value="ERS852478_00292"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033TBE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN50075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="215" mass="25666" checksum="63F1412835F530A9" modified="2016-09-07" version="1">MERHAFAMKVKDDMMNSYRQKLGEIWKDLTLFLDRNQVKNFSIWNTERLIFGYYEKEDDAELNAEEKAVRDVLIEKMAETFEWISEPGQDMRLMYHNYGFIRENKELIRHRVFMTRLKDGCEEEYKARHDGLIAQRGDTVDPGPDSNFTIWSAGGYIFGYDEIDTTMEVDETPEARETTVAWETRQLEIMDWITDDVDWMTGEWHPASRRLAWHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XPW2</accession>
    <name>A0A173XPW2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199605.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53764">
        <property type="protein sequence ID" value="CUN53764"/>
        <property type="gene ID" value="ERS852478_00413"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN53764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="124" mass="13269" checksum="558BFFCFC891E112" modified="2016-09-07" version="1">MKKCHEDISVYTVAADGGDSISSSTTNGSRDIPSDLLNMWHRGSFSSASASLNYHFGKHGSGVGTSNIVSYAQSAKNFKSNLSGAKSSKVNGSTPNVTRWKKNGKYIDICGSKNIGKIISYDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XTZ3</accession>
    <name>A0A173XTZ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">helD</name>
        <name evidence="9" type="ORF">BWLFYP14_02047</name>
        <name evidence="7" type="ORF">ERS852478_00433</name>
        <name evidence="8" type="ORF">ERS852523_02740</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
            <strain evidence="8 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000031">
        <property type="protein sequence ID" value="CUP76693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706647.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000011.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000051_gene792"/>
    <dbReference type="EnsemblBacteria" id="CUN54397">
        <property type="protein sequence ID" value="CUN54397"/>
        <property type="gene ID" value="ERS852478_00433"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP76693">
        <property type="protein sequence ID" value="CUP76693"/>
        <property type="gene ID" value="ERS852523_02740"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3973">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="201"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="222"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN54397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP76693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX65456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="685" mass="80701" checksum="1906CC6336BB9917" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y5M7</accession>
    <name>A0A173Y5M7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">argJ</name>
        <name evidence="8" type="ORF">ERS852478_00559</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380402.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59224">
        <property type="protein sequence ID" value="CUN59224"/>
        <property type="gene ID" value="ERS852478_00559"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023394451" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023394450" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="190"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN59224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="407" mass="42848" checksum="26755CFE96B3A933" modified="2016-09-07" version="1">MKIIDGGVTAAKGFKAAAVAAEIKYKGRTDMAMVYSEVPCVAAGTFTTNVVKAAPVKWDQDIVYNHPSAQVVICNSGIANACTGAEGYGYCKETADAAAEILGVAADSVLVASTGVIGMQVPIDRIKNGVKMMAPKLDGSLEAGTEAAKAIMTTDTKKKEVAVQIEIGGKTVTVGGMCKGSGMIHPNMCTMLGFVTTDAKISKKMLQEALSEDVKDTYNMVSVDGDTSTNDTVLLLANGLAENPEITEKGEDYETFKAALNYINTTLAKKIAGDGEGATALFEVKIIGAESKEQAVTLSKSVVTSSLTKAAIYGHDANWGRILCAMGYSGAEFDPEKVDLFFESKAGKIQIIENGVAVDYSEEEATKILSEEAVTAIADVKMGDATATAWGCDLTYDYIKINADYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y6B3</accession>
    <name>A0A173Y6B3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pheromone autoinducer 2 transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_00555</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199707.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59100">
        <property type="protein sequence ID" value="CUN59100"/>
        <property type="gene ID" value="ERS852478_00555"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN59100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="382" mass="42513" checksum="C905A39D5FECAF83" modified="2016-09-07" version="1">MQLDKENIKKIRWLIAFAILLYLGVQNLHIVISTVRVLLGFLFPFIIGFGIAFILNIPMKFIEHHLFGKALKQEKKTAQKLARPVSLVLSICFVICIIVIVMLVVVPELGATFVNIAKKIEENIPVFQKWIDNVFGNNPEVVKWAQSLDIEPGKIIDSVLGVLKNGVNNIVSSTVSITIGLLTTAMNVSIGFVFACYVLLQKEKLLQQIKKAMYAMFPEKPVRYLAHVWNLANRIFSSFITGQCIEAVILGSMFFVSMTILHFPYAMLVGVLISFTALIPLFGGIIGCWVAFFLILMISPVKAVLFLGLFLILQQIEGNLIYPHVVGGSVGLPSIWVLVAVTLGGSLMGIAGMLIFIPTVSVIYTLFREWVYARLEKKQLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y8U7</accession>
    <name>A0A173Y8U7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">phoR_1</name>
        <name evidence="10" type="ORF">ERS852478_00590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60279">
        <property type="protein sequence ID" value="CUN60279"/>
        <property type="gene ID" value="ERS852478_00590"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
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        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
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    </dbReference>
    <dbReference type="Pfam" id="PF00512">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="269"/>
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            <begin position="277"/>
            <end position="494"/>
        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN60279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="497" mass="55836" checksum="8379A4B387269F6C" modified="2016-09-07" version="1">MTVLRTDRKHASNCMTEENGVEKVKKRKNFFRSLRFRILIILIILGIVPGVIVTYTMLHNYQNRAVAMLTETVGDQCDILCNLIIRENYLNDTDSEVVNSKLELFSNVYNGRILLADRDFKIVSDTFHTEEGKTLLSSLAVACLKGEETSNYDARSKVLELAVPVQSPDVQQLQGVMLVSVSAVDIAETLAEMEQRGVMLIGSIVVLSVFLAWLLSTILVKPLARVTKAIEDLTDGMLDEEISVPDYTETELITDAFNKMVNRMKILDESRQEFVSNVSHELKTPLTSMKVLADSLVGQQGVPEELYQEFMSDITAEIDRENKIITDLLSLVKMDKKAADVNITHMDINQLLEDILKRLRPIADRRNIDLILDCFRPVDADVDEVKFTLAVSNLVENGIKYNVDDGWVRVSLDADHKYFYITVADSGMGIPEDSIERIFERFYRVDKSHSKEIGGTGLGLAITKSSIAMHHGTIKVFSKEGEGTTFSVRIPLSYIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YUK7</accession>
    <name>A0A173YUK7_9FIRM</name>
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        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF2899)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199789.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
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    <dbReference type="EnsemblBacteria" id="CUN66926">
        <property type="protein sequence ID" value="CUN66926"/>
        <property type="gene ID" value="ERS852478_00754"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021552">
        <property type="entry name" value="ArsP_2"/>
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    </dbReference>
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            <begin position="12"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CUN66926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="284" mass="30616" checksum="15F430C619EA7EBC" modified="2016-09-07" version="1">MSEIILDSVIDSIKLLPFLFLTYLFMEWLEHKTGAAARKRIRTAGKFGPVWGGLLGVIPQCGFSAAASSLFAGRVITVGTLIAVYLSTSDEMFPIMISNAVPVVTIVKILTCKAVIGILSGLVLEYVYTHILKKQEPDVDIHEICEEERCHCEHGVISSAAFHTLKVFVYIFLISLALNIIIGLVGEETLAGLFTGTPIAGELIAALVGLIPNCASSVVITQLYLDHIIGAGAMMAGLLVNAGVGLLILFRLNRDRIQNLKIVGVLYGLGVFWGIIIEFAGIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YYJ8</accession>
    <name>A0A173YYJ8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GntR family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">HTH-type transcriptional repressor YtrA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional repressor yvoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yvoA_1</name>
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        <name evidence="3" type="synonym">yvoA_3</name>
        <name evidence="5" type="ORF">BWLFYP14_01723</name>
        <name evidence="2" type="ORF">ERS852478_00798</name>
        <name evidence="3" type="ORF">ERS852523_02988</name>
        <name evidence="4" type="ORF">GT728_12530</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN68600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000037">
        <property type="protein sequence ID" value="CUP83988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000030">
        <property type="protein sequence ID" value="MZL34004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706402.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000158_gene1657"/>
    <dbReference type="EnsemblBacteria" id="CUN68600">
        <property type="protein sequence ID" value="CUN68600"/>
        <property type="gene ID" value="ERS852478_00798"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP83988">
        <property type="protein sequence ID" value="CUP83988"/>
        <property type="gene ID" value="ERS852523_02988"/>
    </dbReference>
    <dbReference type="GeneID" id="66493572"/>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
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    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN68600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP83988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL34004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="123" mass="13761" checksum="1C137542F0375495" modified="2016-09-07" version="1">MEIIISNSSDKPIYEQIAMQIKSLIMNGTLSAGEALPSMRALAKDLHISVITVQRAYEDLTRDGFIETVSGKGSFVASPNKEFIQEEQLRIAEELLEKVAIIGRTHGISYEQMANILKLFFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YZC5</accession>
    <name>A0A173YZC5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotidyltransferase domain protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Nucleotidyltransferase domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Predicted nucleotidyltransferases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BWLFYP14_01676</name>
        <name evidence="3" type="ORF">ERS852478_00828</name>
        <name evidence="4" type="ORF">ERS852523_03027</name>
        <name evidence="6" type="ORF">GT712_14295</name>
        <name evidence="5" type="ORF">GT728_07145</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
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                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
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        <property type="protein sequence ID" value="MZS90207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="CABHOF010000037">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000038_gene3315"/>
    <dbReference type="EnsemblBacteria" id="CUN69542">
        <property type="protein sequence ID" value="CUN69542"/>
        <property type="gene ID" value="ERS852478_00828"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP84947">
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        <property type="gene ID" value="ERS852523_03027"/>
    </dbReference>
    <dbReference type="GeneID" id="66493629"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
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            <dbReference type="EMBL" id="CUP84947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL32981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS90207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX64819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="97" mass="11257" checksum="8E39D0464235F18B" modified="2016-09-07" version="1">MNDTGIRPEVIEEIRNLAQKYDIEKVILFGSRARGDFRRTSDIDIAVTGGDFARFALDVDEETSTLLEYDIVNLDRDMQDELRESIEKEGRILYEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z237</accession>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="123" mass="14229" checksum="FC569F7572D9FADC" modified="2016-09-07" version="1">MKTVKTPAGIFTINKVKIPSAYTCAAEQKIEYISENHVQIITMNQAVSFGDQILSPRICQSCMNPEKITIYPLEIEYFGEKVFFTDHYSVKEWKKGDPLPEIHEWYPHIKKARCNPCRNCGRC</sequence>
</entry>
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    <accession>A0A173ZNR0</accession>
    <name>A0A173ZNR0_9FIRM</name>
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    <reference evidence="1 2" key="1">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="gene ID" value="ERS852478_01044"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN77076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="107" mass="11989" checksum="EDF7E18BF242B03D" modified="2016-09-07" version="1">MAINLEILDASQSQLTQNEQVKNMIDKGCDVVCVNLVDRTDEGIEAVKNEEMLGTVYNDKEGQAREMLNLAFVIATDGDKSDIPLIDGKYVRTPYHKLTLENIEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZWZ4</accession>
    <name>A0A173ZWZ4_9FIRM</name>
    <protein>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
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    </reference>
    <reference evidence="3 5" key="2">
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                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="CUN80972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX66835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="276" mass="30981" checksum="B52AF4E732FCAF5C" modified="2016-09-07" version="1">MKKTLLKYFTVALITISTISMPLTVKAAQKSNISIRPNVAYSKYDITGDGKADKIRINFKSESYLNIEVNGKKSFSLNAQNIYLVNADLYTLNGNKHFLKLKCQDIDNDHIDYDKLLTYKSGKLVSAVNLMSHRKGAFNARHNSFTQKVGANYIQIRMQSMPGGVGSIQYTITYKLSGSSLKLSKTTYPVTYSKSYNPLLGGQNMWKCAKSLNIKNAPNGNIIYTTDAYEVCTVNKIKYSGGSAYIYIRAEDADISGWVRCPNSYTSRFFEESLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A0E2</accession>
    <name>A0A174A0E2_9FIRM</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">spoIIIAC</name>
        <name evidence="6" type="ORF">BWLFYP14_03080</name>
        <name evidence="2" type="ORF">ERS852478_01154</name>
        <name evidence="3" type="ORF">ERS852523_00475</name>
        <name evidence="5" type="ORF">GT712_03535</name>
        <name evidence="4" type="ORF">GT728_00685</name>
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    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
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    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP07694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704108.1">
        <property type="nucleotide sequence ID" value="NZ_JADPFJ010000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2148"/>
    <dbReference type="EnsemblBacteria" id="CUN82041">
        <property type="protein sequence ID" value="CUN82041"/>
        <property type="gene ID" value="ERS852478_01154"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07694">
        <property type="protein sequence ID" value="CUP07694"/>
        <property type="gene ID" value="ERS852523_00475"/>
    </dbReference>
    <dbReference type="GeneID" id="66493990"/>
    <dbReference type="eggNOG" id="ENOG5032ZY3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009570">
        <property type="entry name" value="Spore_III_AC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025664">
        <property type="entry name" value="Spore_III_AC/AD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06686">
        <property type="entry name" value="SpoIIIAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02848">
        <property type="entry name" value="spore_III_AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN82041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP07694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL31749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="64" mass="7257" checksum="0F7A8C94783D7A5A" modified="2016-09-07" version="1">MEVSLIFKIAAVGILVSVLCQILKHSGRDEQAFLVSLAGLLMVLFWIVPYIYELFESIQQLFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A1D1</accession>
    <name>A0A174A1D1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mn-containing catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_03102</name>
        <name evidence="2" type="ORF">ERS852478_01132</name>
        <name evidence="3" type="ORF">ERS852523_00453</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the manganese catalase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP07104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81315">
        <property type="protein sequence ID" value="CUN81315"/>
        <property type="gene ID" value="ERS852478_01132"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07104">
        <property type="protein sequence ID" value="CUP07104"/>
        <property type="gene ID" value="ERS852523_00453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007760">
        <property type="entry name" value="Mn_catalase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05067">
        <property type="entry name" value="Mn_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN81315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP07104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="32" mass="3817" checksum="DA4664D395EF6FB0" modified="2016-09-07" version="1">MWNYEKRLQYPINITQPNAKIAQYIMSQYGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A382</accession>
    <name>A0A174A382_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amylosucrase</fullName>
            <ecNumber evidence="3">2.4.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ams</name>
        <name evidence="3" type="ORF">ERS852478_01186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83142">
        <property type="protein sequence ID" value="CUN83142"/>
        <property type="gene ID" value="ERS852478_01186"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047669">
        <property type="term" value="F:amylosucrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11324">
        <property type="entry name" value="AmyAc_Amylosucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044077">
        <property type="entry name" value="Amylosucrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="154"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN83142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="693" mass="80098" checksum="A3DCB74FEAEE65BD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A459</accession>
    <name>A0A174A459_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199952.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83472">
        <property type="protein sequence ID" value="CUN83472"/>
        <property type="gene ID" value="ERS852478_01195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN83472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="87" mass="10099" checksum="6ABB7A7E06C4D79B" modified="2016-09-07" version="1">MMKTMRKIMEGATAACISAEMYYCFLSGAPVRGTERILYMILAGIFCISAWVTGMGILWYVRWLRRRNKELENMIKILLKNADKLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A5G9</accession>
    <name>A0A174A5G9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="8">BPG-independent PGAM</shortName>
            <shortName evidence="8">Phosphoglyceromutase</shortName>
            <shortName evidence="8">iPGM</shortName>
            <ecNumber evidence="8">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 14" type="primary">gpmI</name>
        <name evidence="14" type="ORF">ERS852478_01197</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199954.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83547">
        <property type="protein sequence ID" value="CUN83547"/>
        <property type="gene ID" value="ERS852478_01197"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
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                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
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                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
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                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10 13">2789STDY5834863</strain>
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    </reference>
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        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
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                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="12 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000016">
        <property type="protein sequence ID" value="MZS89288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053500.1">
        <property type="nucleotide sequence ID" value="NZ_WWVF01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88602">
        <property type="protein sequence ID" value="CUN88602"/>
        <property type="gene ID" value="ERS852478_01309"/>
    </dbReference>
    <dbReference type="GeneID" id="66494933"/>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="337"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="478"/>
            <end position="480"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN88602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS89288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="VUX64793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="539" mass="57216" checksum="8736AC80938056FA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AJC3</accession>
    <name>A0A174AJC3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease MutS2</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">mutS2</name>
        <name evidence="11" type="ORF">BWLFYP14_01619</name>
        <name evidence="10" type="ORF">ERS852478_01277</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN87546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200002.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN87546">
        <property type="protein sequence ID" value="CUN87546"/>
        <property type="gene ID" value="ERS852478_01277"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03280">
        <property type="entry name" value="ABC_MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01069">
        <property type="entry name" value="mutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="9">
        <location>
            <begin position="717"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="333"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN87546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX64764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="793" mass="88594" checksum="092AB4FDE490BFBA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AL36</accession>
    <name>A0A174AL36_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_01643</name>
        <name evidence="1" type="ORF">ERS852478_01301</name>
        <name evidence="2" type="ORF">ERS852523_00893</name>
        <name evidence="3" type="ORF">GT728_08220</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
            <strain evidence="2 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN88380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000007">
        <property type="protein sequence ID" value="CUP20781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000015">
        <property type="protein sequence ID" value="MZL33183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705688.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN88380">
        <property type="protein sequence ID" value="CUN88380"/>
        <property type="gene ID" value="ERS852478_01301"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP20781">
        <property type="protein sequence ID" value="CUP20781"/>
        <property type="gene ID" value="ERS852523_00893"/>
    </dbReference>
    <dbReference type="GeneID" id="66494940"/>
    <dbReference type="eggNOG" id="ENOG5033P3A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN88380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP20781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="77" mass="9018" checksum="5F7F8600AC51A95B" modified="2016-09-07" version="1">MTAVKERIIGAVSIMSDKDANIFWHIIQKHFKLPDTFADIEKVEPDETDLIMLKEIENNPDCHEFISQEELMKELNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AQY7</accession>
    <name>A0A174AQY7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN89886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200025.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN89886">
        <property type="protein sequence ID" value="CUN89886"/>
        <property type="gene ID" value="ERS852478_01342"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN89886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="442" mass="52076" checksum="1DEFEB5B6695E146" modified="2016-09-07" version="1">MQIISSYGVELRKQNIPVRQTLEIYRSAVSYLIGIYVQVWEKLAEIPDAKRRFNAAEHLVHTTKKNHACFDFDIRFPKMPSYLRRSAIQHALGTVSSYKTRLDLWEKTDGKSGKPKLVYENHAMPVFYRDVMYREGAERKDEAYLKLYDGHDWKWFCVRLEHTDMEYLRKYWSGKKASAPTLEKRHHKYFLRFTYTEEVTLTKTHVKEQVICSVDLGINTDAVCTIMRADGTVLGRKFIDHPSEKDRMYRALGRIRRFQREHGSAQTQGRWTYTKRLNTELGKKIAGAIVRYAEENHADVIVFEYLEMQGKIPGKKKQKLHLWRKRDIQRRCEHQAHRKRMRVSRICAWNTSRLAYDGSGAVTRDWEDYSLCTFQTGKRYNCDLSASYNIGARYFIRELLKPLPVTERSLLEAKVPPVKRRTSCVYADLRKLHSEMELLKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AR82</accession>
    <name>A0A174AR82_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Xylulose kinase</fullName>
            <shortName evidence="3 5">Xylulokinase</shortName>
            <ecNumber evidence="3 5">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">xylB_3</name>
        <name evidence="3 5" type="synonym">xylB</name>
        <name evidence="8" type="ORF">ERS852478_01381</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN91132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379839.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN91132">
        <property type="protein sequence ID" value="CUN91132"/>
        <property type="gene ID" value="ERS852478_01381"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02220">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3 5" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="FGGY_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="7">
        <location>
            <begin position="256"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="site" description="Important for activity" evidence="3">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN91132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="506" mass="56359" checksum="4B292BDA001B7331" modified="2016-09-07" version="1">MKYVIGVDLGTSATKTILVDQNGKIVAEASVKYPMYQPENGWAEQDPSDWSEAAISTIKSVVEKGQVNGKDVRGIGISGQMHGLVMLNEENQVIRRSIIWCDQRATKQVEEMLELPMEKWMKITANPPMAGWTAAKILWIRENEPELFAKCRHIMLPKDYVRFILTGKYATDASDASGMQMLDVKNRCWSQEILDFLKVDRELLGDVYESPEVVGNLLPKIAEKCGLSTETVVVAGGSDNACAAIGTGIVREGQAFTTIGTSSIVYTHLKKYQEIPEGALHLCCCAVPGCWHTMGGPQSAGLSIEWMKNNFCRDLIQKAEEENVSFYDKINELTKDIPLGSERLIYLPFLMGERTPHIDPKYRGAFIGLNIIHGQAHMLRAIMEGVVYSLADCNEILKKLGTEVVSMRACGGGSRSPVWRKIMADLYKCDVHTLKQEEGPAYGAAILAGVGAGIYSSIQEACDAFIEEDGITECDLKEAEEYEKFHKIYDRFYENIKENLHALYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ATC7</accession>
    <name>A0A174ATC7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200038.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000055.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90698">
        <property type="protein sequence ID" value="CUN90698"/>
        <property type="gene ID" value="ERS852478_01370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN90698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="288" mass="33223" checksum="7F3CBCAF94D2EF03" modified="2016-09-07" version="1">MNKQDSVDLLHPSMLQIQYLMELEKVGKKRGSVTMIADICGVSHGPVSRFFKECMERGYLTEKYEFTAEGTHALLIYKKLLRDVKLYLKAMNIPEKEIPEKMRQLIENVDYDLLRNMIRNGRQTAEHIEKQDKSQEDARDSQHSRESNAYFIEKILEKGKFQVGIAVHQMSRNSETRISMAHQGFEHLALIRNNTRGSWLELTIREVNGQSRIDGTRMWGHISSLKYEKQGQLYEAVIKDGHLRIPLSACHFFRGRMGNVKGTVHITVACNIGNAHMPESTAVLTFWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AYF5</accession>
    <name>A0A174AYF5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Probable endonuclease 4</fullName>
            <ecNumber evidence="1">3.1.21.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nfo_1</name>
        <name evidence="1" type="ORF">ERS852478_01388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.21.2" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN92530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN92530">
        <property type="protein sequence ID" value="CUN92530"/>
        <property type="gene ID" value="ERS852478_01388"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN92530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="71" mass="7746" checksum="F3DCE29EF7B48621" modified="2016-09-07" version="1">MLYIGNHTSSSRGYLAMGKQMLANGGNTFAFFTRNPRGGKAKDIDPQDVQAFGQLAEENHFGKLVAHAPYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B255</accession>
    <name>A0A174B255_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phage tail sheath protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myoviridae tail sheath protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200092.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94299">
        <property type="protein sequence ID" value="CUN94299"/>
        <property type="gene ID" value="ERS852478_01446"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035089">
        <property type="entry name" value="Phage_sheath_subtilisin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04984">
        <property type="entry name" value="Phage_sheath_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_sheath_1" evidence="2">
        <location>
            <begin position="199"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN94299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="469" mass="51108" checksum="0268FAC4CBB4D3A0" modified="2016-09-07" version="1">MAEYFQIPEVGTKVRPGSYFNVDKNGDDDSFGAIDGVVVAVFKATFGPVDKVTVLERGDDYTTIYGDGLTTDLIREVLYGGAKKVICCRLNGTGGAVASVSLTAATGKVKITAKHPGEMPFSVTIRNRLTDKDRKECIIYTGTTEFEKVYFSAGDNEAASLVSAFANSKNFTANLEESAKGIMTNVNQTAFTGGKNPTVATANYSAAFSQAEKYFFNTICVDTEDTAVHALLQAFLDRIYETSQFGIGVVAEKDNKDLDERMNAAAGFDGENIVYVLNPKVFINEGTLDGYQTAGLIAGLIAATPANQAVTHMVITRYVDLAEPLTNTQIIKAELKGCLVLSKSTEDEVWIDAGINTLINLPDNKDKGWKKIRRVRTRYELLYRANAQSDALVGKVDPDKNGKATIIGKIQGIINAMIKEKKLTAGTVTESTTYIADADNCYFDLDIIDKDSAEHIYSFYKFRFSTNAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BKF4</accession>
    <name>A0A174BKF4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclic lactone autoinducer peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005344225.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPF010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00709">
        <property type="protein sequence ID" value="CUO00709"/>
        <property type="gene ID" value="ERS852478_01604"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009229">
        <property type="entry name" value="AgrD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04223">
        <property type="entry name" value="quorum_AgrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO00709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="52" mass="6050" checksum="E4C6509A173CD957" modified="2016-09-07" version="1">MKKIIRKNLGIKLLGAVNCLALCLTAYTANLACNWLYYQEDEPEEVKKMRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BSY6</accession>
    <name>A0A174BSY6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">rpsC</name>
        <name evidence="16" type="ORF">BWLFYP14_00261</name>
        <name evidence="12" type="ORF">ERS852478_01663</name>
        <name evidence="13" type="ORF">ERS852523_01289</name>
        <name evidence="15" type="ORF">GT712_08960</name>
        <name evidence="14" type="ORF">GT728_04720</name>
    </gene>
    <organism evidence="12 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 17">2789STDY5834863</strain>
            <strain evidence="13 18">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="14 20 21" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 21">BIOML-A1</strain>
            <strain evidence="15 20">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="16 19" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP33483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707259.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2978"/>
    <dbReference type="EnsemblBacteria" id="CUO02790">
        <property type="protein sequence ID" value="CUO02790"/>
        <property type="gene ID" value="ERS852478_01663"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP33483">
        <property type="protein sequence ID" value="CUP33483"/>
        <property type="gene ID" value="ERS852523_01289"/>
    </dbReference>
    <dbReference type="GeneID" id="66496126"/>
    <dbReference type="eggNOG" id="COG0092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="11">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO02790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUP33483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZL32522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZS89197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VUX67420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="218" mass="24287" checksum="9C2C15E04CE53CE9" modified="2016-09-07" version="1">MGQKVNPHGLRVGVIKDWDSRWYADADFADYLVEDYNIRTFLKKKLYSAGVSKIEIERASDRVKIIIYTAKPGIVIGKGGAEIEKVKAELKKFTDKKLIVDIKEVKRPDKDAQLVAENIALQLENRISFRRAMKSTMQRTMKAGAKGIKTSVSGRLGGADMARTEFYSEGTIPLQTLRADIDYGFAEADTTYGKVGVKAWVYNGEVLPTKGTKEGSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BWW4</accession>
    <name>A0A174BWW4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mannosyl-3-phosphoglycerate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200183.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05572">
        <property type="protein sequence ID" value="CUO05572"/>
        <property type="gene ID" value="ERS852478_01723"/>
    </dbReference>
    <dbReference type="GeneID" id="66492351"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO05572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="261" mass="29998" checksum="BF52400609A67D25" modified="2016-09-07" version="1">MNGILCADMDNTIIYSYKRNIGENKLNVELYNGREISFISEKTHDLLKKVSEKMTIIPTSTRTEEQYKRIDLDIGIVPYALVCNGGVLLVNGKRDREWYLESLQMIQNSRPEMEKAQQILAGDSRRKFELRFLDELFIFTKCEKPEEVVEDLQAKLTTKLVDVFHNGEKVYVVPVNLSKGMAVRRLRKRLQPAYIIAAGDSEFDVSMVEESDLGLVPAGFKKIYGNGSDRFKETVMEMEAGRLFSETLLEKCLVLYFKEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BYY7</accession>
    <name>A0A174BYY7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bacterial capsule synthesis protein PGA_cap</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">ERS852478_01734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200199.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05913">
        <property type="protein sequence ID" value="CUO05913"/>
        <property type="gene ID" value="ERS852478_01734"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="PGA_cap" evidence="5">
        <location>
            <begin position="73"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="449"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO05913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="544" mass="60444" checksum="05ACAA68E6089C2C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C556</accession>
    <name>A0A174C556_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhamnulokinase</fullName>
            <ecNumber evidence="3">2.7.1.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rhaB_2</name>
        <name evidence="3" type="ORF">ERS852478_01764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.5" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200243.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06836">
        <property type="protein sequence ID" value="CUO06836"/>
        <property type="gene ID" value="ERS852478_01764"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008993">
        <property type="term" value="F:rhamnulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="255"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO06836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="489" mass="55669" checksum="31ED6CF9331DF6E5" modified="2016-09-07" version="1">MNKKVIAVDIGASSGKMAFGEFDGSQLLVREYRDFANRPVDIGTALYWDVFSLHNAIVDGMAYFKEKYGEADAVAVDTWGASYGLLDKKGRLMEPVYHYRDERTRTTIQDMNSVMNTYELFRLTGCQCNRTYTLPQLYSYRAENSAVLYNASSMLLLPDLLGYFLTGVKTTEMTIAGTSCLMENRQENWSIEVARRFGIPEKLYTEIVEPRTFKGNLRQEIQIQTGMKNTRLVATVGHDSAAAVAAIPDFGENKLYISIGTNVSMGVERSECLLSREGYLKGFKNTGGIDRKKIIYRDFSACWHLNEFIRTRKEQGITYSFVDLINMALEVKNPVPWFDVEVLSFNEAGGDFCRKMNQYFAQTGQRELTEDGEFVRSIYESIVLKIRHYAEALKELGIIYGRINIINGAVRNSLLMQMISNALGKEVYAGMEYATLTGNLLTQLYAMGEVKTVKEMRSLSAECFSMKQYGPEEQEYWTETAEKYERIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C5U7</accession>
    <name>A0A174C5U7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bicarbonate transport ATP-binding protein CmpD</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cmpD</name>
        <name evidence="5" type="ORF">ERS852478_01816</name>
        <name evidence="6" type="ORF">ERS852523_02638</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
            <strain evidence="6 8">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000029">
        <property type="protein sequence ID" value="CUP73771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055152213.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000014_gene1207"/>
    <dbReference type="EnsemblBacteria" id="CUO08514">
        <property type="protein sequence ID" value="CUO08514"/>
        <property type="gene ID" value="ERS852478_01816"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP73771">
        <property type="protein sequence ID" value="CUP73771"/>
        <property type="gene ID" value="ERS852523_02638"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO08514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP73771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="263" mass="29853" checksum="83208F9560C58262" modified="2016-09-07" version="1">MAGEERVTKLKIDNVKKIYQTRKGEMTALNGVNLDIKENEFICVVGPSGCGKSTLLNIIAGLDTPTSGAVYIDGKKIEGTGTERGVVFQQYALFPWLTVLKNVMFGLKLQGKSDAEAKEIAMKYIKMVQLEDFVNHYPKELSGGMKQRVAIARAYAVKPEVLLMDEPFGALDAQTRTQLQTELLKTWESERKTCFFITHDVDEAIILAQRVIVMSARPGRIKDIVDIDIPYPRDQETKMSPRFMELKNHIWSQVYQEYLEVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C8R3</accession>
    <name>A0A174C8R3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucosamine-6-phosphate deaminase 1</fullName>
            <ecNumber evidence="1">3.5.99.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nagB_2</name>
        <name evidence="1" type="ORF">ERS852478_01809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.99.6" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO08285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200288.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO08285">
        <property type="protein sequence ID" value="CUO08285"/>
        <property type="gene ID" value="ERS852478_01809"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO08285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="273" mass="31111" checksum="1D2612245789E82B" modified="2016-09-07" version="1">MGHSYYSYTKEELVGNGPKLPVIVMEDNAEVFHSMAVEMVDEIRKHNEKGEKTVFICPVGPVGQYPYFVDMVNEQNISLKNVWFINMDEYLDDEKQWISKDHPLSFRGFMQRTVYDKVRPELVMPEDQRVFPDPNHPEYISELIEKLGGVDICFGGIGINGHVAFNEADPSLTNEEFLAQKTRVLKITKETRTANAIGDFNGALEDMPHYCITIGINEISHARKIRLGCFRNWHRAVVRRAAYGEATSDFPVSLLTSHPDINLKITEFVAALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CGL5</accession>
    <name>A0A174CGL5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannosylfructose-phosphate synthase</fullName>
            <ecNumber evidence="3">2.4.1.246</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mfpsA_1</name>
        <name evidence="3" type="ORF">ERS852478_01914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.246" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200434.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12244">
        <property type="protein sequence ID" value="CUO12244"/>
        <property type="gene ID" value="ERS852478_01914"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103011">
        <property type="term" value="F:mannosylfructose-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="12"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="180"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO12244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="368" mass="42208" checksum="A8E53D5880F7C880" modified="2016-09-07" version="1">MKILQIGMGNVAGGLEAFVMNYYRVLVHMNIQFDFVCMYDKIAYEEEIRKLGGRIYYIPNVKKNYQGYIKELKKILKETKYDAVHVNMLSAANIVPLRVAHTMKVPKIIAHSHSSSCPGLIRKIMDNWNRPKIAKYATDRIACGEMAGRWLFGDKAFQSGQVTLINNAIQAEKFSFSEKDRDSLRKELGWENKTVIGHVGRFDIPKNHDRMLDIFQQIVSEKKDVMLCLVGPKEGLYKEIKEKTVQKGLEDKVYFAGKQENIRRYLSAMDVFLFPSVFEGVPFALIEAQANGLACVMSEAVSEEAVVFPERVRRLSLDRDNIQWAAAVMAMSSMNREAADLIKMRLSDAHFNIETEAKRLKDLYYHTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CII6</accession>
    <name>A0A174CII6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11336">
        <property type="protein sequence ID" value="CUO11336"/>
        <property type="gene ID" value="ERS852478_01884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO11336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="38" mass="4269" checksum="55BA84240388A0EC" modified="2016-09-07" version="1">MSKKGYSRPGLFGCINHYDVNGNKVGESQSGFWQYEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CJP5</accession>
    <name>A0A174CJP5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gdhA</name>
        <name evidence="10" type="ORF">ERS852478_01905</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200429.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11935">
        <property type="protein sequence ID" value="CUO11935"/>
        <property type="gene ID" value="ERS852478_01905"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="9">
        <location>
            <begin position="202"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="7">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO11935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="444" mass="48591" checksum="D3BE4FDF8201FA1C" modified="2016-09-07" version="1">MSYTEEVYERVVAQNPNEPEFHQAVKEVLDSLKVVIDKNEEKYRKLSILERLVEPERIISFRVPWVDDKGVVQVNKGYRVQFNSAIGPYKGGLRFHPSVNQGILKFLGFEQIFKNSLTGLPIGGGKGGSNFDPKGKSDREVMAFCQSFMTELSKYIGADMDVPAGDIGVGGREIGYLYGQYKRNRGLYEGVLTGKGLSYGGSLIRTQATGYGLVYMLNEMVKAKNDTISGKTLIVTGSGNVAIYAVEKAAELGGKVVAMCDSNGYIYDPEGIKLDIVKDIKEVKRGRIKEYADRVEGATYTEGKGIWNIKCDIYLPCATQNELDLDAVKILIANGCKYVAEGANMPTTREATDYLMANGVIFMPGKAANAGGVATSALEMCQNSARLSWTAEEVDTKLHQIMVDIFHKVDDASKRYGMEGNYVAGANIAGFEKVVDAMIAQGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CTD4</accession>
    <name>A0A174CTD4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylglycerol lysyltransferase</fullName>
            <ecNumber evidence="6">2.3.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Lysylphosphatidylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mprF</name>
        <name evidence="7" type="ORF">ERS852478_01980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-lysyl-tRNA(Lys) = 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-lysyl)-sn-glycerol + tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:75792"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="EC" id="2.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the LPG synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.3" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707518.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15100">
        <property type="protein sequence ID" value="CUO15100"/>
        <property type="gene ID" value="ERS852478_01980"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050071">
        <property type="term" value="F:lysyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO15100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="343" mass="38871" checksum="6D955C3F0E71C86D" modified="2016-09-07" version="1">MRNKKKAIFNTIFLILIFSITVYMVFKGEDLGEIIHTVRQADPVYLLVSVVCVVLFILGESVIIFYMMRTLGAKVKMGHCALYSFVGFFFSCITPSASGGQPMQIYFMKKDKLPIPVTTLVLMIVTITYKAVLVVIGIVIWIFGRGFLEGYLGQYMWVFYLGVGLNIFCVTFMMILVFAPGLAKWIMVKGLKLIEHFRFLKPKTTRLEKLEASMDQYHETAAFWASHKLVILKVLLITMVQRILLFTVTYWVYRSLGFHGYSIITLTILQSVISVSVDMLPLPGGMGISESLYLVMFAPVFGEALLPAMLLSRGISYYAQMLISAVMTCVAYFIIGRKEQEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CV69</accession>
    <name>A0A174CV69_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Allophanate hydrolase subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_01999</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993688.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15720">
        <property type="protein sequence ID" value="CUO15720"/>
        <property type="gene ID" value="ERS852478_01999"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1984">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00724">
        <property type="entry name" value="urea_amlyse_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHS2" evidence="4">
        <location>
            <begin position="24"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO15720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="335" mass="37096" checksum="7700127D91AA1817" modified="2016-09-07" version="1">MGIRILKGGMMTTVQDLGRYGYQSQGFSVAGVMDVRSFKIANLLLDNPENEAVLEITLIGPTLEFTSATIIAITGGDFQPTINGEPAPMYTALYMNKGDVLKFGSARTGSRGYIAFSSYLDIPVVMGSRCTNLKSGLGGFKGRKLEADDYIGFRIKRRYLPFFLSRKLDMDEFDQTEATLRVVMGPQDGMFSKQGIKTFLGSEYTVTNEFDRMGCRLEGPFIAPKKTSDIISDGIAFGAIQVPSHGKPIILLADRQTTGGYGKIATVASVDIPKLVQRKTDDKIHFKAITVQEAQALYVEEMKELDGLRKIIHQPCKEVLDCRLVAKRLRKLFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D0R9</accession>
    <name>A0A174D0R9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200525.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO17630">
        <property type="protein sequence ID" value="CUO17630"/>
        <property type="gene ID" value="ERS852478_02059"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033QK7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019638" evidence="1">
        <location>
            <begin position="36"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO17630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="230" mass="26257" checksum="786A64F348D48B8E" modified="2016-09-07" version="1">MSMKNRFAGKCRSYLAFFLLAAFAALLFFPRVASAAAKPTAKQLKVTYRGFEYDNDTAKLYLKLSLKNTSSYTITKVKMGYEIPIMEDGTITQTFSVTINPGKTVNKTVYIGKMTQQPYKVPKVKCLSFWYKSATPKLNQLKVSYKGYEYNPNTGELYITARMQNTSSYTITKVTMYFEIPLDETATPTKTYNVNIPSGKTKNYRFKIGRMADAPDGKVLVKCKKFWYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D6F3</accession>
    <name>A0A174D6F3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antirestriction protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005423194.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000028.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21211">
        <property type="protein sequence ID" value="CUO21211"/>
        <property type="gene ID" value="ERS852478_02153"/>
    </dbReference>
    <dbReference type="GeneID" id="66495333"/>
    <dbReference type="eggNOG" id="COG4734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009899">
        <property type="entry name" value="ArdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041895">
        <property type="entry name" value="ArdA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041896">
        <property type="entry name" value="ArdA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041893">
        <property type="entry name" value="ArdA_dom3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07275">
        <property type="entry name" value="ArdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO21211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="167" mass="19308" checksum="ED3EB029E2BE798C" modified="2016-09-07" version="1">MIDDMQVYIANLGKYNEGELVGDWFSFPLDEEVIAERIGLNAEYEEYAIHDTDNFPMEISEYISIEELNRIYEQLEELPDYLLDDLDSFISCYGSLEELVEHKDDIILYSGCETMTDLAYYLIDEEQVLGEIPSSLQNYIDYEAYGRDLDIEGTFIATNAGICEVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7J3</accession>
    <name>A0A174D7J3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">baeS</name>
        <name evidence="10" type="ORF">ERS852478_02124</name>
        <name evidence="11" type="ORF">GT712_11540</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000021">
        <property type="protein sequence ID" value="MZS89688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053945.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20259">
        <property type="protein sequence ID" value="CUO20259"/>
        <property type="gene ID" value="ERS852478_02124"/>
    </dbReference>
    <dbReference type="GeneID" id="66495361"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="70"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="131"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO20259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZS89688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="347" mass="39399" checksum="0C91465EB9694B1D" modified="2016-09-07" version="1">MEQKKEKGLRIRSCLTGAIWLALVFSTVISALLFAFLNHFFNLPGSIPVLGWLLIFNTLIAGLITSFINAKLLEPITRLSKAMKKVSQGDFEQHLETNSRIAEVGESYQSFNVMTKELRATEVLQMDFVSNVSHEFKTPINAIEGYTMLLQGEELSQDQEEYVEKILFNTQRLSGLVGNILLLSKLENQNIPMKKTEYRLDEQIRQAFLSLETKWTEKEIGFQVELEEVKYTGNEGLFMHIWINLLDNAIKFSPSKGTITMFLKQEQDSVKFILEDEGPGIEDDVKSRIFDKFYQVDGSHKAEGNGLGLALVKRIVDSAGGTIKAENREYGGCRFVIELPKQKDEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7S0</accession>
    <name>A0A174D7S0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable chromosome-partitioning protein parB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">parB_3</name>
        <name evidence="5" type="ORF">ERS852478_02173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379906.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21782">
        <property type="protein sequence ID" value="CUO21782"/>
        <property type="gene ID" value="ERS852478_02173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="4">
        <location>
            <begin position="64"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO21782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="323" mass="36796" checksum="D7FB078C8319AF4B" modified="2016-09-07" version="1">MAGRKNGLGRGLDALFPEKKSAVKESVKKATVKTENKTVVPEKTTDDTTEESNRSTIGHKKTAMIVKISSVEPNVNQPRKQFDEDALLELSESIKQYGVLQPLLVSDKKDYYEIIAGERRWRAAKLAGLKEIPVIVKEFSEQELVEISLIENIQREDLNPVEEAMAYKRLIDEFHLKQDEIAERVGKSRTAVTNAMRLLKLSEKVQQMLIDEMITAGHARAILSIADKEKQESIAMKIFDEKLSVRETEALVKRMLEPPKTAKKSKFSSAEDAIYESLEEKMKSIMGTRVQIHRKKNDKGKIEIEYYSKDELERIIDLFESIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D985</accession>
    <name>A0A174D985_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">GTP pyrophosphokinase YwaC</fullName>
            <ecNumber evidence="3 4">2.7.6.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ywaC_3</name>
        <name evidence="4" type="ORF">BWLFYP14_02821</name>
        <name evidence="3" type="ORF">ERS852478_02130</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="3 4"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005347231.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20446">
        <property type="protein sequence ID" value="CUO20446"/>
        <property type="gene ID" value="ERS852478_02130"/>
    </dbReference>
    <dbReference type="GeneID" id="66495355"/>
    <dbReference type="UniPathway" id="UPA00908">
        <property type="reaction ID" value="UER00884"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015970">
        <property type="term" value="P:guanosine tetraphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="2">
        <location>
            <begin position="65"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO20446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="226" mass="26705" checksum="E98C7C1D49236EE8" modified="2016-09-07" version="1">MTKDEVKKLRMNSPESLQFLNNATKFYNLMMMYRCAIREIQTKLEVLDDEFSVENNRNPISFIKTRIKKPNSIYDKLQKMGYEFTTENIQTYLNDVAGVRIVCAFIDDIYMISDLITQQDDIKVIEIKDYIKNPKSNGYRSYHMIVEIPVFFAKGKTPMRVELQIRTNGMDFWATLEHQLRYKKGIEEMPGYDEISEELLHSARAIIEADNEMQRIKDKIGMFHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DHT6</accession>
    <name>A0A174DHT6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">HTH-type transcriptional regulator GltR</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">LysR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gltR</name>
        <name evidence="5" type="ORF">BWLFYP14_01468</name>
        <name evidence="3" type="ORF">ERS852478_02216</name>
        <name evidence="4" type="ORF">GT712_11575</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO23705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000022">
        <property type="protein sequence ID" value="MZS89694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705469.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23705">
        <property type="protein sequence ID" value="CUO23705"/>
        <property type="gene ID" value="ERS852478_02216"/>
    </dbReference>
    <dbReference type="GeneID" id="66495135"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO23705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="288" mass="32892" checksum="42D8EDC66D1A8289" modified="2016-09-07" version="1">MKEIRDRYEIFLKVCETGSFSKAAEALNYTQSGISQMMAGFEEELGVQLFARAKKGVTLTDNGRMLMPYIQEMTNQKDKLRQAAFNINHKIEGKLRIGSFSSVTAMWMPEVIHYFNRNYPQVEVQIFDGNYDEIRDWIIHGQVDCGFLSSIVADNLKFYPLCEDPLCAVMQKNHPLAEKKSVRLEELLEYPFIIETPGCDNDILHLLERCGKEPKTSYSFRDDTLIMAFVKNGLGVTISQKLVMKAFANDVESRPLEPGRSRIIGLAFVKTMNSVVTKILLEYLKGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DIA1</accession>
    <name>A0A174DIA1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+-dependent transporters of the SNF family</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Sodium:neurotransmitter symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BWLFYP14_01469</name>
        <name evidence="8" type="ORF">ERS852478_02217</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO23736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705470.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO23736">
        <property type="protein sequence ID" value="CUO23736"/>
        <property type="gene ID" value="ERS852478_02217"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO23736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX64616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="463" mass="50634" checksum="C6C2330D3419EF22" modified="2016-09-07" version="1">MERKSNHFSGQLGFVLAAAGSAVGVGNLWRFPYLAAKDGGGLFLIIYFILVLTFGFTLLTSDIAIGRRTQKSAIGAYAEMKPKWKFLGILTFLVPVLIMTYYAVIGGWITKYAVVYLTGQAKAAAADDYFTSFITSSTSPVIFALIFMGVTAFIVYNGVQDGIEKVSKWMMPVLLVLVVIISIYSLTLKHTDSSGQVHTGIQGFLYYLTPNLEGLTVQRFLQILLDAMSQLFFSLSVSMGIMITYGSYVKPDVNLNKAVNQIEIFDTGVAFLAGAMIIPAVFVFSGTEGMGAGPSLMFVSLPKVFAAMGKAGIFVGILFFVTAIFATLSSCISVLESIVANCMEIFHTGRKKTVSVLSAVYLAASAIIALGYSIFYVEVELPNGSTGQLLDIMDYISNSVMMPFIALLSTILIGWVMTPDYVIDEMERNGSRFRRKKLYRIMIRYVAPVMMFILFLQSTGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DKL6</accession>
    <name>A0A174DKL6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anaerobic benzoate catabolism transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_023921725.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000098.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO24566">
        <property type="protein sequence ID" value="CUO24566"/>
        <property type="gene ID" value="ERS852478_02247"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO24566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="68" mass="7991" checksum="D76C702618618B82" modified="2016-09-07" version="1">MKNRVKELREKEGLTQKKLGEKVNVSRQAINAIETGKYDPSLWLAYDIAQLFNMSIEEVFNFKESERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DN99</accession>
    <name>A0A174DN99_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">23S rRNA (Guanosine(2251)-2'-O)-methyltransferase RlmB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative TrmH family tRNA/rRNA methyltransferase</fullName>
            <ecNumber evidence="2 5">2.1.1.-</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="5">TrmH family tRNA/rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rlmB</name>
        <name evidence="5" type="ORF">BWLFYP14_01523</name>
        <name evidence="2" type="ORF">ERS852478_02277</name>
        <name evidence="3" type="ORF">ERS852523_02402</name>
        <name evidence="4" type="ORF">GT728_09240</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.-" evidence="2 5"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO25486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000025">
        <property type="protein sequence ID" value="CUP67255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000018">
        <property type="protein sequence ID" value="MZL33377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705522.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000018.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000118_gene3306"/>
    <dbReference type="EnsemblBacteria" id="CUO25486">
        <property type="protein sequence ID" value="CUO25486"/>
        <property type="gene ID" value="ERS852478_02277"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP67255">
        <property type="protein sequence ID" value="CUP67255"/>
        <property type="gene ID" value="ERS852523_02402"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO25486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP67255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="245" mass="26498" checksum="BA34800CA271514A" modified="2016-09-07" version="1">MSEQIEGRNAVLEAFRSGKCVDKLFILDGCQDGPVRTIAREARKKDTIINYVAKERLDQLSETGAHQGVIAQVAAYEYASVEDILAKAREKGEDPFIFILDNIEDPHNLGAIIRTANLAGAHGVIIPKRRAVGLTSTVAKTSAGALNYTPVAKVTNLGHTIDELKEQGMWFVCADMGGETMYNLNLTGPIGVVIGNEGEGVSRLIREKCDFVASIPMKGDIDSLNASVAAGVLGYEIVRQRLQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DZ64</accession>
    <name>A0A174DZ64_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Met) cytidine acetate ligase</fullName>
            <ecNumber evidence="1">6.3.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tmcAL</name>
        <name evidence="2" type="ORF">ERS852478_02380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + cytidine(34) in elongator tRNA(Met) = AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:58144"/>
            <dbReference type="Rhea" id="RHEA-COMP:10693"/>
            <dbReference type="Rhea" id="RHEA-COMP:10694"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TmcAL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.-" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200736.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29355">
        <property type="protein sequence ID" value="CUO29355"/>
        <property type="gene ID" value="ERS852478_02380"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01539">
        <property type="entry name" value="TmcAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008513">
        <property type="entry name" value="tRNA(Met)_cyd_acetate_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37825">
        <property type="entry name" value="PTHR37825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05636">
        <property type="entry name" value="HIGH_NTase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO29355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="436" mass="48395" checksum="471CB3ABEEE96DD1" modified="2016-09-07" version="1">MKTAGIIAEYNPFHKGHEYQIRYTKEKLKADYVIVAMSGDYVQRGTPALISKHARAEMALRCGADLVLEMPVSVSTASAEAFAMGGVSLLDGLGVVDMLCFGSESGEISALKELAEILVEEPEEYKKLLKSFLSEGLTFPAARSQALTEYFKNPRNFNGDDFDGVLTPLLNEVTQILNTPNNILGIEYCKALLRLNSRICPVTIRREGMGYHETTVPEGNSTVLSPDLQSPTDFFASATAIRNLILQNSPNPDALTSQIPEPAFPVFQKAVNSGEFLTENSLDSILSYCLMKENGKSLSSYMDVSEDLARRIINQQNLLLSFSQSVSVLKTRELTQTRIQRALLHIILNIHTAPTQIPFARVLGFRKESSELLSRIKQHSRIPLITKLADAQNLLDSEGNQILSETVFSSNLYEKLLCLKTGRKFCHESQKQLIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E6L7</accession>
    <name>A0A174E6L7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yfcA</name>
        <name evidence="8" type="ORF">BWLFYP14_00508</name>
        <name evidence="6" type="ORF">ERS852478_02513</name>
        <name evidence="7" type="ORF">ERS852523_03690</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">2789STDY5834863</strain>
            <strain evidence="7 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO33552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000060">
        <property type="protein sequence ID" value="CUQ03355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000004">
        <property type="protein sequence ID" value="VUX62627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703716.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000029_gene634"/>
    <dbReference type="EnsemblBacteria" id="CUO33552">
        <property type="protein sequence ID" value="CUO33552"/>
        <property type="gene ID" value="ERS852478_02513"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ03355">
        <property type="protein sequence ID" value="CUQ03355"/>
        <property type="gene ID" value="ERS852523_03690"/>
    </dbReference>
    <dbReference type="GeneID" id="66495264"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO33552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUQ03355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX62627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="252" mass="26613" checksum="5BA356737B725FBD" modified="2016-09-07" version="1">MELTIQTFLIVCPLVFLAGLVDSIAGGGGLISLPAYLLAGVPMHNAIATNKLSSATGTAISTARLCKNKFVDWGVALPCISMALVGSFAGAHIALLASDKILKWMLIPVLPIVAFYVMKKKNLDDNSNVEISRKKQWILCAVCSLAVGCYDGFYGPGTGTFLLILYTGVAKLPVAKASGTMKLANLSSNIMALVVFLFSGKIVIYLGLAASVFSIAGHYVGSGMVMKNGNKIVRPIILIVLVLLFIKIITGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E7Z7</accession>
    <name>A0A174E7Z7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cqsS</name>
        <name evidence="6" type="ORF">BWLFYP14_02148</name>
        <name evidence="5" type="ORF">ERS852478_02472</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32569">
        <property type="protein sequence ID" value="CUO32569"/>
        <property type="gene ID" value="ERS852478_02472"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO32569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="113" mass="12378" checksum="2A71EE3B9C765803" modified="2016-09-07" version="1">MEIAEFLLTNAGAVIIRASNGKKAVEAFAKSGVGEVNVILMDIMMPVMDGMEATREIRTMNRSDASAVVIIAMTANAFTEDKTKALKPGMDDYLTKPLESEKLIRALSRYKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EF88</accession>
    <name>A0A174EF88_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">folD</name>
        <name evidence="9" type="ORF">ERS852478_02575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380771.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35947">
        <property type="protein sequence ID" value="CUO35947"/>
        <property type="gene ID" value="ERS852478_02575"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="132"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO35947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="284" mass="29950" checksum="55115B9C70F717D7" modified="2016-09-07" version="1">MAKQLLGKEVTAALNEKIKANVAELQGKGVNPTLCIIRVGENPSDISYERGATKRCETLGVACEKILLPEDVSQEELLATIDKVNKDDSIHGVLLFRPLPKHLDQAVIENALAPEKDVDCMTDLSMSGVFTGKKIGFPPCTPQACMEILDHYGIDCTGKKAVVIGRSLVVGKPAAMMLVKKNATVTICHTRTVNMPSVAREADIIIVAAGRAGVVGAEYVKEGQTIIDVGINVNAEGKLCGDVDYAAVEPIVDAITPVPGGVGSVTTSVLVGHVVEAAMRKVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EPE6</accession>
    <name>A0A174EPE6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Maltose operon transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">malR</name>
        <name evidence="6" type="ORF">ERS852478_02672</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO39147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379875.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO39147">
        <property type="protein sequence ID" value="CUO39147"/>
        <property type="gene ID" value="ERS852478_02672"/>
    </dbReference>
    <dbReference type="GeneID" id="66492664"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO39147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="335" mass="37458" checksum="2BD89BAD64B04677" modified="2016-09-07" version="1">METEEKKIYTIEDIARELGVSKTTVSRAISGKGRISQATRDRVRAFIKEHDYRPNVVAKGLAQRKTYNIALLMPKDYVATEFLFFKDCMNGICEMASSYEYDIIISMIDGADVSQIQRLEANRKVDGIIVSRAVVSSKVQKYLKNCKEPYILIGPSSDPEVPFVDNKNQEAGKELTSIMLMKGFRNLALLGGNQSYNVTGSRYQGFLEAHEEMGVSVNENLIFMDTDNQAAVSDAVKRLLEEGADGIVCMDDVICSMCLSSLREKKISVPAEIKIASMYDSKNLEYNNPPITSIRFDTVRLGKMACAKLLNILGEKPLEDTVPLNYQVVLRESTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F3K7</accession>
    <name>A0A174F3K7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44932">
        <property type="protein sequence ID" value="CUO44932"/>
        <property type="gene ID" value="ERS852478_02850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012332">
        <property type="entry name" value="Autotransporter_pectin_lyase_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021299" evidence="2">
        <location>
            <begin position="28"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO44932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="784" mass="81001" checksum="9BA590A83B8AA525" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F3Z5</accession>
    <name>A0A174F3Z5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_01034</name>
        <name evidence="2" type="ORF">ERS852478_02812</name>
        <name evidence="3" type="ORF">ERS852523_03638</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000058">
        <property type="protein sequence ID" value="CUQ01936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705200.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43648">
        <property type="protein sequence ID" value="CUO43648"/>
        <property type="gene ID" value="ERS852478_02812"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ01936">
        <property type="protein sequence ID" value="CUQ01936"/>
        <property type="gene ID" value="ERS852523_03638"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50304CC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO43648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ01936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX63656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="162" mass="18275" checksum="E80CD0195B33C83D" modified="2016-09-07" version="1">MPKNKFQEVIFTIIMVFVMVYAMICYNIVLNTGTMTNETFLLAFHELTFMGPIAFILDFFIIGGLAKKIAFGIVDMRRDNPFHLVLAISAVSVAFMCPCMSFAATVLIKHAPASQIIPTWLQTTAMNFPMAFFWQIFYAGPFVRFIFGKLFPEKEKAAASAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FA29</accession>
    <name>A0A174FA29_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjP_18</name>
        <name evidence="7" type="ORF">ERS852478_02877</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45656">
        <property type="protein sequence ID" value="CUO45656"/>
        <property type="gene ID" value="ERS852478_02877"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="72"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO45656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="278" mass="31246" checksum="826A88A33ABD6AC5" modified="2016-09-07" version="1">MKNTKKIISKILIYFALILGVLFCLVPLYWMIRSSLMNTVEVFMMPPRWIPSKFMWENYQEVFDTLPFGKYFLNSFIVTGGCVVGTMLTSSICAYGLARIKWRGRNVVFACIISSMMLPVAVTLIPTFLMWRTIGITDSFIPLIVPAWFGGGAFYIFLLRQFYLGIPKDFDEAAYLDGASHIQIFTKIILPITKPALAVVGMFAFLNSWNDFLSPLVYLNSEKKYTVALGLQLFTGSYRGEWNLMMAAACLVLAPVVVVFAIGQKYLVEGVTMSGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FD79</accession>
    <name>A0A174FD79_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione import ATP-binding protein GsiA</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gsiA_11</name>
        <name evidence="6" type="ORF">ERS852478_02952</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201027.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO48134">
        <property type="protein sequence ID" value="CUO48134"/>
        <property type="gene ID" value="ERS852478_02952"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO48134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="329" mass="36315" checksum="F8AA2B0622B1D84E" modified="2016-09-07" version="1">MAEKLLEVKNLRTEFKRDKTWVTAVNNVSFSIQPGEILGLVGESGCGKSVTSLSIMKLLARNSKISNGEILLNGKDLLKEDKKGMRKIRGREVAMIFQEPMNSLNPCMRIEKQLTEAILLHNNFSKEEAHNRAFEVLKSVGIPEPDMTLKSYPHQLSGGMCQRVMIAMAMSCEPELLIADEPTTALDVTIQAQILELMEDIRAKKNTGILMITHDLGVVAEMCSRVVVMYAGRIVEEAPVQELFADPKHPYTQGLIGSVPKLGSGVESLPSIPGSVPDLSVMPKGCKFAPRCKYAMDICHQQEPELADINEAGTRKCRCHLLNKIGKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FGL7</accession>
    <name>A0A174FGL7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Making large colonies protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mlc_3</name>
        <name evidence="4" type="ORF">ERS852478_02989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional repressor of xylose-utilizing enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO49313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201056.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49313">
        <property type="protein sequence ID" value="CUO49313"/>
        <property type="gene ID" value="ERS852478_02989"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO49313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="377" mass="42027" checksum="5697DA4D6094BD5D" modified="2016-09-07" version="1">MSEKGLTNISLKKINKSKVYQYIYRKKTTSKLQIVQELQMGLSTVSQNLNLLEQEGLIEKNGFFESTGGRKANALQIVSDFKISIGIGILKGMFHITAVDLYGNAFYTDTIPLPYSNTPDYYKQVTDAVKEFISSRQYDNDKVLGISIATQGITSPDHTTVLYGDIMNNAGMKLDDFSRYLPYPCYLEHDSKSAAFLELWNHPELDSAVIILLNRNLGGGIITNHQIHQGISMHSGTLEHICINPDGPLCYCGSRGCLETYCSANALEQAAGIPAKEFFPLLREKKSPQIIQIWKDFLNHLAFAMKNLNLVIDAPIILSGYLAPYFTEEDIEYLAEHLHTAAPFILDKAQILVGTNGQYTPAIGAALHYVEKFIQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FMC2</accession>
    <name>A0A174FMC2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative F0F1-ATPase subunit (ATPase_gene1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201082.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000049.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50667">
        <property type="protein sequence ID" value="CUO50667"/>
        <property type="gene ID" value="ERS852478_03030"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG503360H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032820">
        <property type="entry name" value="ATPase_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09527">
        <property type="entry name" value="ATPase_gene1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO50667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="89" mass="10108" checksum="E3AA3BCF3CA61B92" modified="2016-09-07" version="1">MKQWSEIIRNVTMLSQLGLSLITPVLICLAVCWLIVSKTGAGGWVYIPGFFFGLGGSGTVAYKFYLSINRQQRKENKKRKNKVSFNRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FNA1</accession>
    <name>A0A174FNA1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="10">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycogen branching enzyme</fullName>
            <shortName evidence="10">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">glgB_1</name>
        <name evidence="10" type="synonym">glgB</name>
        <name evidence="13" type="ORF">ERS852478_03053</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379951.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51722">
        <property type="protein sequence ID" value="CUO51722"/>
        <property type="gene ID" value="ERS852478_03053"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102752">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="6 10 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="12">
        <location>
            <begin position="153"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10 11">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 11">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO51722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="628" mass="72862" checksum="6AADB2EF7F4FD54D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FP54</accession>
    <name>A0A174FP54_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF3794 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Domain of uncharacterized function (DUF3794)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03066</name>
        <name evidence="3" type="ORF">GT728_15255</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO52042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000043">
        <property type="protein sequence ID" value="MZL34513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379929.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52042">
        <property type="protein sequence ID" value="CUO52042"/>
        <property type="gene ID" value="ERS852478_03066"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024300">
        <property type="entry name" value="DUF3794"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12673">
        <property type="entry name" value="DUF3794"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="469"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO52042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="516" mass="58707" checksum="0A896DE904FB259E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FS29</accession>
    <name>A0A174FS29_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO52297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201105.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52297">
        <property type="protein sequence ID" value="CUO52297"/>
        <property type="gene ID" value="ERS852478_03075"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030JFI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025051">
        <property type="entry name" value="DUF3990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13151">
        <property type="entry name" value="DUF3990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO52297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="244" mass="28122" checksum="9708B419348DED32" modified="2016-09-07" version="1">MKSHVNIMDSDTAYENVIVYHGSDHILKEPIYQGGKTDNDYGNGFYTTEYKDRAKSWAVLNGDPEYSFVNRYILNTSGLKIMDLNDYGILAWIAEVIANRGTSLESAEITGSRIVEMYRISTADFDIIKGYRADDSYTQVIEAFLLNQINIEEIKKLFYKGSLGNQIFLKSQKAFKQIEWKDAWQVYKDESDVTADFHARREVNQFFSARNRAILLEGFEVPGITVRTAMGKFLLYHQEGDFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FXN6</accession>
    <name>A0A174FXN6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201165.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53379">
        <property type="protein sequence ID" value="CUO53379"/>
        <property type="gene ID" value="ERS852478_03104"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z81B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045798">
        <property type="entry name" value="TrbL_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19478">
        <property type="entry name" value="TrbL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO53379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="289" mass="31721" checksum="93BE6181303F6563" modified="2016-09-07" version="1">MESILEAINEWIKEILIGAINGNLSTMFGDVNEKVGTIAAEVGKTPQGWNANIFNMIQNLSENVIVPIAGLVITYVLCYELISMVTEKNNMHDVDTFMFFKWFFKAFVAVFLVTHTFDITMAVFDMAQHIVSGAAGVIGGNTNIDVAEALAAMQEGLNDMEIPELLLLVMETSLVSLCMKIMSVLITVILYGRMIEIYAYCSVSPIPFATMTNREWGQIGNNYLKGLFALGFQGFLIMICVGIYAVLVGEMVVADNLHSAIFSLAAYTVILCFSLFKSGALAKSIFNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G2L6</accession>
    <name>A0A174G2L6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">phoR_8</name>
        <name evidence="10" type="synonym">phoR_1</name>
        <name evidence="10" type="ORF">BWLFYP14_00678</name>
        <name evidence="9" type="ORF">ERS852478_03141</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO54575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000015">
        <property type="protein sequence ID" value="VUX62929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201194.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000088.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54575">
        <property type="protein sequence ID" value="CUO54575"/>
        <property type="gene ID" value="ERS852478_03141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="130"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO54575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX62929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="343" mass="38155" checksum="8F7A19381380C9FA" modified="2016-09-07" version="1">MKFQNLSVKRLFSLVAIGLVLSMSGITIALFLVTKQIAVLLTGGALLLCALVGIFVLTQAFGKRLSQFTADLCQTLDHMIAGNEAPQRPEDSETQLARIGHRLARLYQIMQENRRRVDEERQELQTLVSDISHQVKTPVSNLKMATDTLLEKPMTEAERTDFIRGIRSQTDKLDFLFQALVKTSRLETGVIQLDKKPGRLFDTVAQAMSGIVYAAEKKEIAVSVDCPEDLTVSHDSKWTSEALFNLLDNAVKYTPAGGKIAVSVVLWEMYVEVKVTDTGKGISESNQAAIFRRFYREEEVHEQQGVGIGLYLAREIVTRQGGYIKVVSEPGKGSEFSIMLPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G5Z6</accession>
    <name>A0A174G5Z6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide transporter, OPT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_03221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707353.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57401">
        <property type="protein sequence ID" value="CUO57401"/>
        <property type="gene ID" value="ERS852478_03221"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004814">
        <property type="entry name" value="Oligopep_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="PTHR31645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00733">
        <property type="entry name" value="TIGR00733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO57401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="632" mass="65737" checksum="591EF34AD6F8887C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GBZ7</accession>
    <name>A0A174GBZ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-methionine transport system permease protein metI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">metI</name>
        <name evidence="7" type="ORF">ERS852478_03243</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201246.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57935">
        <property type="protein sequence ID" value="CUO57935"/>
        <property type="gene ID" value="ERS852478_03243"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="14"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO57935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="219" mass="23448" checksum="FDF7675E46689430" modified="2016-09-07" version="1">MWDHETIMMIVQGVGETLYMTVLSTVLGYLFGLPMGVLLAVSDKEGLKPNAVLYKILDAIANIVRSIPFLILLILLIPFTRAVVGKSYGSTATVVPLVVAAIPFIARMVESSIKEVDAGVIEAARAMGASNMRIIVKVLLVEARTSLITGATIAIGTILGYSAMSGAVGGGGLGDIAIRYGYYRYQSDIMIITVILLVVLVQIFQSVGMLIANKIDRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GT25</accession>
    <name>A0A174GT25_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SOS response-associated peptidase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Uncharacterized ACR, COG2135</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BWLFYP14_02258</name>
        <name evidence="7" type="ORF">ERS852478_03424</name>
        <name evidence="8" type="ORF">GT712_16305</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO63979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000042">
        <property type="protein sequence ID" value="MZS90580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63979">
        <property type="protein sequence ID" value="CUO63979"/>
        <property type="gene ID" value="ERS852478_03424"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO63979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS90580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX65893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="137" mass="15489" checksum="AF632BF3C1300019" modified="2016-09-07" version="1">MCSRYYIDPGMTEDISRVVQNIDGRIWLAQGDTRPTDVAPVIGQSEHGLELGICRWGYPLSKSKGLVINARVETVLDKPSFQNGILYHRLLIPAGGFYEWNSLKEKSIFTRLDSSVLYMAGFCDWFDNSKMPVLLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GU69</accession>
    <name>A0A174GU69_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02285</name>
        <name evidence="2" type="ORF">ERS852478_03451</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64638">
        <property type="protein sequence ID" value="CUO64638"/>
        <property type="gene ID" value="ERS852478_03451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO64638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="42" mass="4767" checksum="E76C351C77BCDDC0" modified="2016-09-07" version="1">MTVSFVIFTIVYGTVSSILGTYIVRILDKKCKNDRHSSDSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H2A6</accession>
    <name>A0A174H2A6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67507">
        <property type="protein sequence ID" value="CUO67507"/>
        <property type="gene ID" value="ERS852478_03540"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO67507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="218" mass="24615" checksum="09F7664F355B3361" modified="2016-09-07" version="1">MKTELKNCLSLYKIFYSCAFILILCVIHPIIYYEEIGSAIQSPIAFLTIIFCSDTYLMEVKSKRADVFHLYDQKKQLKVISQRVGVQILYLLILSCVGYVLFFWQKPGSVNEGISGIQIFLLYFIAMFGTIWLWSICSVILCTLLRNMWAGIGCLFGIVIGLISKAGSSFFGNLGLFSFSFCEPTQLMSESWIYGTLVSFIAGLFLFAVLPMALKKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H370</accession>
    <name>A0A174H370_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma factor SigX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_044999042.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000037.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67847">
        <property type="protein sequence ID" value="CUO67847"/>
        <property type="gene ID" value="ERS852478_03555"/>
    </dbReference>
    <dbReference type="GeneID" id="61431745"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO67847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="142" mass="17234" checksum="F4D02ABA53FBF7A6" modified="2016-09-07" version="1">MAYNKAREEKKWRLWKEAEEKQLRSLGVNEDDIEKLRVHDWAIFNSDRRYYQRVQETGTYLDELVEDTTQPEVKTVEDFLDSIENQHLYQVLIKVDRLTLQIALMKIEGYSTREIAVYLDITEKAVYRRMDRLKEKLKKLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H4Z2</accession>
    <name>A0A174H4Z2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68130">
        <property type="protein sequence ID" value="CUO68130"/>
        <property type="gene ID" value="ERS852478_03560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO68130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="179" mass="20974" checksum="41D83056A7B5F947" modified="2016-09-07" version="1">MRKKYTYDDIYNFTHGVLNNNIVEKTSEKEIGEWEVISGSLFLYQDNDGNEYTEEEASDKISELEEQIEEAESQVDDLQEEMDKDIPDCNLQETEDKINELEGKIEHWKGVIETLQYGEIIDVCQYYIVSESAFETWLKGSSELVLYNEELDMYVWCICFYGSDWRDVLTDIPIPEKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HDH4</accession>
    <name>A0A174HDH4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arm-DNA-bind_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71190">
        <property type="protein sequence ID" value="CUO71190"/>
        <property type="gene ID" value="ERS852478_03658"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028259">
        <property type="entry name" value="AP2-like_int_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14657">
        <property type="entry name" value="Arm-DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arm-DNA-bind_4" evidence="1">
        <location>
            <begin position="11"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="130" mass="15813" checksum="2E76353FF755656B" modified="2016-09-07" version="1">MPAYKDNKTGTWFVKFYCKDWTGENKQIKKRGFATKREALDYERNYKIRQENNLDMTFGKFWKLYTEDVKPRVKLNTWLTKWRYRLKSRYSTKGVGIATVERISKRKNGMSIKGMDWKRSIRQRLLNLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HE09</accession>
    <name>A0A174HE09_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gmuF</name>
        <name evidence="6" type="ORF">ERS852478_03707</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000044">
        <property type="protein sequence ID" value="CUO72511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72511">
        <property type="protein sequence ID" value="CUO72511"/>
        <property type="gene ID" value="ERS852478_03707"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014628">
        <property type="entry name" value="Man6P_isomerase_Firm_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036894">
        <property type="entry name" value="PMI_Firm_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO72511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="328" mass="37339" checksum="F9C81DB7D9B181B6" modified="2016-09-07" version="1">MERRNEPLLLRPAGKDYLWGGKRLNDEYGKNIELSPLAETWECSTHPDGVSTVCCGTFDKMELTAVIKAHPEYLGERHKGETTLPILVKLIDARKDLSVQVHPDDDYAKMKEHGQLGKTEMWYVLDAARDAKLIYGLRQDCTKKEMQKALAEGTVMKYLQKVPIHKDDLFFIPAGTIHAIGAGALVAEIQESSNLTYRLYDYDRIGKDGKKRELHIDKALDVADLYGSAEPRQPLRILKYRPGMASELLIRCKYFEVYRMLINTERRQTVHYRADRMAFRVLLCVDGCGTISYDEGTVNFYKGDCVFVPADSEVLTIHGQAQFLDIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HGC1</accession>
    <name>A0A174HGC1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydroxyethylthiazole kinase</fullName>
            <ecNumber evidence="4">2.7.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thiM</name>
        <name evidence="10" type="ORF">ERS852478_03757</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.50" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000047">
        <property type="protein sequence ID" value="CUO73943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73943">
        <property type="protein sequence ID" value="CUO73943"/>
        <property type="gene ID" value="ERS852478_03757"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO73943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="215" mass="23189" checksum="43CD0CC1CF68681E" modified="2016-09-07" version="1">MAEHPAEVAEITRSSHALALNLGNITDARMKSMPESLKTAASLHIPVMLDLVGTACSNLRYEFAQKLMNIHMPELLKGNMSELLAMSGQTAHAIGIDAGVQDVLTDANRSHLKELFQEKASRWNTTLLITGKEDMIVSANKCEFITNGTPAMSQITGTGCMLGMICATYLAVTDPFTAALSAAREFGTAGERAEKNSSGPGSFQTELFDQFYNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HH72</accession>
    <name>A0A174HH72_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycogen synthase</fullName>
            <ecNumber evidence="3">2.4.1.11</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000048">
        <property type="protein sequence ID" value="CUO74224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201517.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74224">
        <property type="protein sequence ID" value="CUO74224"/>
        <property type="gene ID" value="ERS852478_03766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="41"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="174"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO74224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="360" mass="40782" checksum="8514A7ADB1BD4E72" modified="2016-09-07" version="1">MKRVCMIVPNRMVKGGIAAVVNGYRGSQLEKDYEITYVESYKDGSKFDKLLKGICGYFHFAYVLMFHKPDVVHIHSSFGPSFYRKMPFIYMASWRKIPIVNHIHGADFDEFYVNAPEEKKAKIKKVYSKCNVLIALSEEWKERLSQIVPEDRIEIIENYSVLHEDALEEKMQRECNNTVLFLGELGKRKGCYDIPAVIAQVKKSIPDVIFVLAGAGSEADEKAIKELIAEKGISDNVKFPGWVRGDTKDKLLREADVFFLPSYNEGMPMSVLDAMGYGLPVVSTNVGGIPKIVHDGENGYCCDPGNVNQFAKGITEILLDRKERKSFGEASWKIVKEGYSLEAHLNRIEQAYKQVLLMDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HKY2</accession>
    <name>A0A174HKY2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YccF domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3 5">inner membrane protein YccF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yccF</name>
        <name evidence="5" type="ORF">BWLFYP14_02987</name>
        <name evidence="3" type="ORF">ERS852478_03790</name>
        <name evidence="4" type="ORF">GT728_20430</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000049">
        <property type="protein sequence ID" value="CUO74891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000102">
        <property type="protein sequence ID" value="MZL35468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000073">
        <property type="protein sequence ID" value="VUX66711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704887.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000102.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74891">
        <property type="protein sequence ID" value="CUO74891"/>
        <property type="gene ID" value="ERS852478_03790"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031308">
        <property type="entry name" value="UCP028777"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028777">
        <property type="entry name" value="UCP028777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="66"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO74891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL35468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="120" mass="13347" checksum="3694DD7AFB23AF9B" modified="2016-09-07" version="1">MRTIGNILWFIFGGLLGGLAWVFAGCIWCITIIGIPVGLQCFKFATLAFWPFGKEIVYGNGMFSFLVNLIWIVFFGWEMALGNLIVGCIWCITIVGIPFGKQFFKMARLSFMPFGASVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HLS4</accession>
    <name>A0A174HLS4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mepA_18</name>
        <name evidence="6" type="ORF">ERS852478_03756</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000047">
        <property type="protein sequence ID" value="CUO73919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73919">
        <property type="protein sequence ID" value="CUO73919"/>
        <property type="gene ID" value="ERS852478_03756"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO73919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="466" mass="49911" checksum="7B50D47BF9049F78" modified="2016-09-07" version="1">MEKDNQSTQEINSQAQNPLGIAPVGGLIAKFAIPAIISMLVSAMYNIVDQIFIGQGVGMLGNAATNVAFPVTTVATALALLLGIGGASNYNLEMGAGQEKKASGIAGTALSSLAISGLILAVIVLMFLKPLLTLFGATADVMPYAVDYTGITAFGLPFYILSVGGNHVVRADRSPTYSMVCIMIGAIINTILDPLFIFGFGWGIKGAAWATVIGQVASGVLVIVYFCKFRKMYLSGGMLKPKLSYLKAIISLGLASCINQIAMAIVQIVLNNILRYYGANSVYGSDIPIACVGVISKVNMVFMAICIGISQGSQPIWGFNYGAKKYDRVRQAYRYSVTACTVIATIFFFCFQIFPHQIVGIFGTGSNLYFQFAERYLKIFMFMTFANGIQPVSSGFFTSIGMAKLGIVMSLTRQVIFLLPLIIIFPLFMGIDGVMYAGPIADAAAFVLAIVFARRELGKMRSAEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HN06</accession>
    <name>A0A174HN06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipid A core-O-antigen ligase and related enzymes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_03771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000048">
        <property type="protein sequence ID" value="CUO74339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201518.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000048.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74339">
        <property type="protein sequence ID" value="CUO74339"/>
        <property type="gene ID" value="ERS852478_03771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO74339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="434" mass="49252" checksum="1C5941BC1F70C376" modified="2016-09-07" version="1">MKLNIRNTIIFLVFGIYPIIPQYFGIMGISAFKLMCLGIVLFACVALGISKSVATSCRNIQIAFGIWLIIMFINAILFKGVVEYFYEILCYYLVGFVIIKCLNTRKRFLRAVDLLIIGAVVASIIGIVESITGFNVFHLLNNMGAQITLQPLRFGFRRIISFTYQTISFCNYCMFALGLIVYRISVCSKGNERKQKYGIAYGFVFIAALLTLSRSILICIIISQLILLYLCGYKVLLKKLLIITSVGMLAVIICSIVLPEILNILQNVAYMLLAVFDDNYAAMLGNVDGTGSGDRKELLKWVWESIDNKWIGMGGSAEFAYSLTERSGIYSYIRTKTSIENQYLNLLYHYGIIGLISMIWVYIQVFIKSIIQAVKNPSEWEGRISFPKMLVVILGTYYISFFGVHQIDEKRIFFCLIFLLIAYCNNKAYLTAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HNG5</accession>
    <name>A0A174HNG5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide deformylase 2</fullName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def2</name>
        <name evidence="2" type="ORF">ERS852478_03781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000049">
        <property type="protein sequence ID" value="CUO74688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057538.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO74688">
        <property type="protein sequence ID" value="CUO74688"/>
        <property type="gene ID" value="ERS852478_03781"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO74688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="136" mass="15694" checksum="8F23BF632C14A40C" modified="2016-09-07" version="1">MVKQIVRDIFFLGQPSKLATKADIQIGKDLQDTLQANRERCVGMAANMIGVRKNIIIVNMGFIDVVMFNPVIVSKHDMYETEEGCLSLDGVRKTTRYQEIEVEYYDFNWKKQRQKLSGWTAQICQHEIDHLSGKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JCT6</accession>
    <name>A0A174JCT6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Biotin carboxylase</fullName>
            <ecNumber evidence="3 9">6.3.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Acetyl-coenzyme A carboxylase biotin carboxylase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">accC_1</name>
        <name evidence="14" type="synonym">accC</name>
        <name evidence="12" type="synonym">accC_2</name>
        <name evidence="16" type="ORF">BWLFYP14_00417</name>
        <name evidence="12" type="ORF">ERS852478_01997</name>
        <name evidence="13" type="ORF">ERS852523_00086</name>
        <name evidence="15" type="ORF">GT712_10320</name>
        <name evidence="14" type="ORF">GT728_08945</name>
    </gene>
    <organism evidence="13 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 17 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 17">2789STDY5834863</strain>
            <strain evidence="13 18">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="14 20 21" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 21">BIOML-A1</strain>
            <strain evidence="15 20">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="16 19" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="3 9"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO96431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000017">
        <property type="protein sequence ID" value="MZL33319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000018">
        <property type="protein sequence ID" value="MZS89453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707547.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2251"/>
    <dbReference type="EnsemblBacteria" id="CUO15656">
        <property type="protein sequence ID" value="CUO15656"/>
        <property type="gene ID" value="ERS852478_01997"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO96431">
        <property type="protein sequence ID" value="CUO96431"/>
        <property type="gene ID" value="ERS852523_00086"/>
    </dbReference>
    <dbReference type="GeneID" id="66495616"/>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004549">
        <property type="entry name" value="Acetyl_CoA_COase_biotin_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00514">
        <property type="entry name" value="accC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO15656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO96431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZL33319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZS89453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VUX62316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="449" mass="49808" checksum="41B31CBD309C226D" modified="2016-09-07" version="1">MFNKILIANRGEIAVRIIRACRNLGIRSVAVYSKEDAKSLHVQLADQRICIGEGPARNSYLNMDRIIAAAENMGADAIHPGFGFLSENSEFVRKCKENGITFIGPDADVIDKMGNKSHARKTMMDAGVPVVPGTKEPVYDAETGKKLAEEIGYPVMIKASSGGGGKGMRVAANEDEFEFQFNMAQRESANAFGDDTMYIERFVENPRHVEIQIMADSHGNVVALGERDCSVQRNHQKLIEESPSPAIDEETRRKMNEYAVLAAKTVGYTNAGTIEFIVDPKGNFYFMEMNTRIQVEHGVTEMVTGTDLIIEQIRVAMGEELSFKQEDIRIKGHAIECRINAEIPEKNFMPSPGVVQHMHLPAGNGVRVDTALYTGYKIPSEYDSMIAKVIVHAPDREAALQKMRSALDEMVVMGVETNLDFQYQIMKNQVFCDGKADTGFIENVLKIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174K6R4</accession>
    <name>A0A174K6R4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">L-cystine import ATP-binding protein TcyC</fullName>
            <ecNumber evidence="6">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tcyC</name>
        <name evidence="9" type="ORF">BWLFYP14_03126</name>
        <name evidence="5" type="ORF">ERS852478_01107</name>
        <name evidence="6" type="ORF">ERS852523_00429</name>
        <name evidence="8" type="ORF">GT712_10520</name>
        <name evidence="7" type="ORF">GT728_00915</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 10">2789STDY5834863</strain>
            <strain evidence="6 11">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 14">BIOML-A1</strain>
            <strain evidence="8 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP06511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000019">
        <property type="protein sequence ID" value="MZS89491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704195.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000045_gene2070"/>
    <dbReference type="EnsemblBacteria" id="CUN80402">
        <property type="protein sequence ID" value="CUN80402"/>
        <property type="gene ID" value="ERS852478_01107"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06511">
        <property type="protein sequence ID" value="CUP06511"/>
        <property type="gene ID" value="ERS852523_00429"/>
    </dbReference>
    <dbReference type="GeneID" id="66492939"/>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN80402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP06511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL31793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZS89491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX66850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="228" mass="25451" checksum="6E4BFEB91966C2F6" modified="2016-09-07" version="1">MVLFEMKNIKKSFGSLEVLKDISLQVEEGEVLSIIGPSGSGKSTLLRCATGLETPDSGEIIKQGDVGLVFQNFNLFPHFSVLKNITDAPIRVQKRKKEEVYAQARTLLKQMGLADRENAYPFQLSGGQQQRVSIARALCMNPKILFFDEPTSALDPELTSEILKVIKDLAAEHITMVIVTHEMTFARDISDHIIFMDKGLIAVEGSPKEVFESEHARMKEFLGKFHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M3M7</accession>
    <name>A0A174M3M7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AbrB/MazE/SpoVT family DNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00940</name>
        <name evidence="4" type="ORF">ERS852523_01168</name>
        <name evidence="5" type="ORF">GT728_01380</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
            <strain evidence="4 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000009">
        <property type="protein sequence ID" value="CUP29726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_044996646.1">
        <property type="nucleotide sequence ID" value="NZ_WWVL01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000054_gene1880"/>
    <dbReference type="EnsemblBacteria" id="CUN73776">
        <property type="protein sequence ID" value="CUN73776"/>
        <property type="gene ID" value="ERS852478_00940"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP29726">
        <property type="protein sequence ID" value="CUP29726"/>
        <property type="gene ID" value="ERS852523_01168"/>
    </dbReference>
    <dbReference type="GeneID" id="66493055"/>
    <dbReference type="eggNOG" id="COG2002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN73776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP29726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL31884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="128" mass="14191" checksum="0BF90EE6FCEBF16E" modified="2016-09-07" version="1">MATATIPLKGSASMESKKVSISSKRQITIPQKFFTLLGFNTEAECIMRGNELVLRPVKENTSGEFAEQILADLIRQGYSGEELLEKFKQTQRKIRPAVEAMLAEADRVAESKSGGYSLEDVFGTEDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M4H4</accession>
    <name>A0A174M4H4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="10">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="10">HMP-P synthase</shortName>
            <shortName evidence="10">HMP-phosphate synthase</shortName>
            <shortName evidence="10">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">thiC</name>
        <name evidence="15" type="ORF">BWLFYP14_01325</name>
        <name evidence="11" type="ORF">ERS852478_00955</name>
        <name evidence="12" type="ORF">ERS852523_01183</name>
        <name evidence="14" type="ORF">GT712_16935</name>
        <name evidence="13" type="ORF">GT728_01450</name>
    </gene>
    <organism evidence="12 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 16">2789STDY5834863</strain>
            <strain evidence="12 17">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="13 19 20" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 20">BIOML-A1</strain>
            <strain evidence="14 19">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="15 18" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ThiC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="10"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000009">
        <property type="protein sequence ID" value="CUP30091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000047">
        <property type="protein sequence ID" value="MZS90697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707069.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000090_gene2570"/>
    <dbReference type="EnsemblBacteria" id="CUN74234">
        <property type="protein sequence ID" value="CUN74234"/>
        <property type="gene ID" value="ERS852478_00955"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP30091">
        <property type="protein sequence ID" value="CUP30091"/>
        <property type="gene ID" value="ERS852523_01183"/>
    </dbReference>
    <dbReference type="GeneID" id="66495213"/>
    <dbReference type="eggNOG" id="COG0422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 10" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="227"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN74234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP30091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL31898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS90697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VUX64283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="436" mass="48478" checksum="FC871B6BDBBED2A0" modified="2016-09-07" version="1">MTQYTTQMDAARQGIITPQMEIVAEKEHFDVEELRELIAKGQVIIPCNKNHKSISPSGVGAKLTTKINVNLGVSRDWKDVDMEYEKVHSAVEMGAEAIMDLSSYGDTRSFRRKLTSECPAMIGTVPIYDAVVYYHKALGKITSEEWIDIVRMHAEDGVDFMTIHCGMNRATAARFKQNKRLMNIVSRGGSIMFAWMEMTGKENPFYEHFDEILDICREYDITLSLGDACRPGCIADATDTAQIEELITLGELTKRAWEKDVQVMIEGPGHMPLNQIAANMEIQKTLCHGAPFYVLGPLVTDVAPGYDHITSAIGGAIAAYSGAAFLCYVTPAEHLRLPNAADVKEGIIAAKIAAHAADIAKGVPGAAEWDYKMSEARKRLDWEEMFKLSMDPEKARRYRAEAKPEKEDTCSMCGNFCAVKNTNRILDGEIVTIFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NKZ3</accession>
    <name>A0A174NKZ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="11" type="ORF">BWLFYP14_02854</name>
        <name evidence="9" type="ORF">ERS852478_02193</name>
        <name evidence="10" type="ORF">ERS852523_01705</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">2789STDY5834863</strain>
            <strain evidence="10 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000015">
        <property type="protein sequence ID" value="CUP46645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000021_gene1701"/>
    <dbReference type="EnsemblBacteria" id="CUO22442">
        <property type="protein sequence ID" value="CUO22442"/>
        <property type="gene ID" value="ERS852478_02193"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP46645">
        <property type="protein sequence ID" value="CUP46645"/>
        <property type="gene ID" value="ERS852523_01705"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="8">
        <location>
            <begin position="53"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO22442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP46645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX66479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="306" mass="34377" checksum="40B2E7D86A7C7025" modified="2016-09-07" version="1">MRICTVTGNKEKGVKIMPRPYLGDPKYTIEVLQKYNFAFQKRFGQNFLIDTHVLDKIIDSAQITKDDFVLEIGPGIGTMTQYLAEAAREVAAVEIDKTLLPILDDTLKDWDNVTVINNDILKVDIRQLALEKNQGRPIKVVANLPYYITTPIIMGLFENQVPVDSITIMVQKEVADRMQVGPGTKDYGALSLAVQYYAKPKIVANVPPNCFMPRPKVGSAVIRLERYEKPPVEVKNEKLMFRIIRASFNQRRKTLVNGLKNSQEIPFSKEQIEQALGMCGLSLSVRGEALTLAQFAQLANAFTEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174PV53</accession>
    <name>A0A174PV53_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Catabolite control protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Substrate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ccpA_2</name>
        <name evidence="6" type="synonym">ccpA_4</name>
        <name evidence="6" type="ORF">ERS852478_02680</name>
        <name evidence="7" type="ORF">ERS852523_02269</name>
        <name evidence="8" type="ORF">GT728_17840</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">2789STDY5834863</strain>
            <strain evidence="7 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO39391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000023">
        <property type="protein sequence ID" value="CUP63471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000063">
        <property type="protein sequence ID" value="MZL34984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379868.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000063.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000115_gene2456"/>
    <dbReference type="EnsemblBacteria" id="CUO39391">
        <property type="protein sequence ID" value="CUO39391"/>
        <property type="gene ID" value="ERS852478_02680"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP63471">
        <property type="protein sequence ID" value="CUP63471"/>
        <property type="gene ID" value="ERS852523_02269"/>
    </dbReference>
    <dbReference type="GeneID" id="66492656"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001761">
        <property type="entry name" value="Peripla_BP/Lac1_sug-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00532">
        <property type="entry name" value="Peripla_BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO39391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP63471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL34984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="330" mass="36798" checksum="EFBB5486CAA1E022" modified="2016-09-07" version="1">MNINEIAKLAGVSRATVSRYLNNGYVSEEKKKNISRVIEETGYQPSSQAQRLRTKKTKLVGVILPKIDSNTISREVAGISDILTKKGYQLILANTNNSVEEELKYLSLFRDNQVDGVIFIATILTKQHREMMKGFKVPIVLLGQQLDGYPCIFQDDYKAAVNLTEQMVKTGKKFGYITVTDKDEAVGRQRKSGVEKVLGENQITLESGCVKCGNFTLESGYEKAKELFTEHPDVDTLICATDTMAVGAANWLKENGYQIPQQVQIAGMGDSFLGKIIEPKLTTVHFFYKTSGMESAKVLVDLIESKETSSVHKEIKMGCKVVLRESHRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QUY9</accession>
    <name>A0A174QUY9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YibE/F-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_00364</name>
        <name evidence="2" type="ORF">ERS852478_01083</name>
        <name evidence="3" type="ORF">ERS852523_02700</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000030">
        <property type="protein sequence ID" value="CUP75557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381228.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000035_gene3823"/>
    <dbReference type="EnsemblBacteria" id="CUN79523">
        <property type="protein sequence ID" value="CUN79523"/>
        <property type="gene ID" value="ERS852478_01083"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP75557">
        <property type="protein sequence ID" value="CUP75557"/>
        <property type="gene ID" value="ERS852523_02700"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014564">
        <property type="entry name" value="UCP031503_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012507">
        <property type="entry name" value="YibE_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41771">
        <property type="entry name" value="PTHR41771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07907">
        <property type="entry name" value="YibE_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031503">
        <property type="entry name" value="UCP031503_mp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN79523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP75557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX67519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="257" mass="28205" checksum="1EDCF47AFF563687" modified="2016-09-07" version="1">MIIFLALVLIILMILIGGERGAVSLMTLAGNIVILFISILLMSIGFPALLLILAAGAGVCYNSLFYQNGNNPKTRAAFLATLLVMLLLFIPIYLIIWRSGSYGLNELQLSEDDFMYYYSTDIHINMLHVAVFVTVFSTLGAVIDTALSVTSSVYEVWTHKNSLTAKELTSSGYQVGKEIIGTTVNTLLFAYLGGSILLFAYVQTQQYNLEIILNSKFLFQDVAIMLSGAIACLFTVPVSIRCVIRQIHHAASETDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174RW64</accession>
    <name>A0A174RW64_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CobW/HypB/UreG, nucleotide-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_00792</name>
        <name evidence="2" type="ORF">ERS852478_03050</name>
        <name evidence="3" type="ORF">ERS852523_03140</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000040">
        <property type="protein sequence ID" value="CUP88436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000020">
        <property type="protein sequence ID" value="VUX63119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000076_gene2624"/>
    <dbReference type="EnsemblBacteria" id="CUO51632">
        <property type="protein sequence ID" value="CUO51632"/>
        <property type="gene ID" value="ERS852478_03050"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP88436">
        <property type="protein sequence ID" value="CUP88436"/>
        <property type="gene ID" value="ERS852523_03140"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3689">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="1">
        <location>
            <begin position="8"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO51632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP88436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX63119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="317" mass="36590" checksum="66E5EB405C99C179" modified="2016-09-07" version="1">MMDDIRVPIYLVTGFLESGKTTFLDFTLQQEYFAIDGKTLLILCEEGEEEYDMDKLKLTNTVVEVIEDEEDLTPQRLAAMDIIHQPERVVIEYNGMWLVSKFEQMELPEGWGIEQEITCVDATTYQVYMANMKSLFMDMIRNTDMVVFNRCKEGDPLPAYRRGIKVANQSAEVIFENEEGEMDDIFQDEMPFDINAPIIEIPPEDYGIWFVDAMDNPDKYVDKIVRFKGRVMKPRGMGSKFFVPGRVAMTCCADDTTFLGYVCRSDYAPHIKEGSWVEVTAKVAFENRTEYQGEGIVLYASDVKECEPLKEEMVYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174S0G6</accession>
    <name>A0A174S0G6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">C_GCAxxG_C_C family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02993</name>
        <name evidence="2" type="ORF">ERS852523_03197</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO49666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000042">
        <property type="protein sequence ID" value="CUP89986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055152847.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000010_gene2775"/>
    <dbReference type="EnsemblBacteria" id="CUO49666">
        <property type="protein sequence ID" value="CUO49666"/>
        <property type="gene ID" value="ERS852478_02993"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP89986">
        <property type="protein sequence ID" value="CUP89986"/>
        <property type="gene ID" value="ERS852523_03197"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010181">
        <property type="entry name" value="CGCAxxGCC_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09719">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01909">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO49666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP89986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="130" mass="13829" checksum="276693BA4DA68F57" modified="2016-09-07" version="1">MENLRCEKAVEKKHNGYNCAQAVACSFCKEASMDEDTLKKITQGFGAGLGTMAGTCGAISGAAVVAGLINQDKAGTSQTVRSVMNQFKQQNGTVICKDLKGVETGRVIRSCDDCVRDAVKFLEDALKSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SFB3</accession>
    <name>A0A174SFB3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">sn-glycerol-3-phosphate transport system permease protein ugpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ugpA_7</name>
        <name evidence="7" type="synonym">ugpA_8</name>
        <name evidence="7" type="ORF">ERS852478_02878</name>
        <name evidence="8" type="ORF">ERS852523_03367</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
            <strain evidence="8 10">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000047">
        <property type="protein sequence ID" value="CUP94408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705933.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000074_gene2293"/>
    <dbReference type="EnsemblBacteria" id="CUO45687">
        <property type="protein sequence ID" value="CUO45687"/>
        <property type="gene ID" value="ERS852478_02878"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP94408">
        <property type="protein sequence ID" value="CUP94408"/>
        <property type="gene ID" value="ERS852523_03367"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="75"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO45687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP94408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="303" mass="34240" checksum="30BA2F54D327C7A4" modified="2016-09-07" version="1">MQTKIKYKMTNREKRENRWGILFSLPCILGFLIFALLPMAVSLGLSFTNFNFTTGGQFIGISNYKNLFSGSDPYFYKSLLVTVIYVALSVPTAIIFSFFIAMLLNTNVKGKGFFRTIFYLPTVVPIVAMAAIWMWIFNPDMGLANNILKAMHLPVSTWLSGESSVIPTLVFINLWTTGSTMVIFLAGMQDVPRQLLEAVEIDGGGFWAKLLHVTIPMMTPTIFYNVVMGIINGFQIFTQSYVMTQGGPNNSSLFYVYYLYREAFEFGRMGNACAVAWVLFLIIMVLTAVIFKFSNRWVYYGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SQM7</accession>
    <name>A0A174SQM7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02149</name>
        <name evidence="3" type="ORF">ERS852523_03570</name>
        <name evidence="4" type="ORF">GT712_06390</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000055">
        <property type="protein sequence ID" value="CUQ00094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000009">
        <property type="protein sequence ID" value="MZS88709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004844214.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000067_gene3477"/>
    <dbReference type="EnsemblBacteria" id="CUO21066">
        <property type="protein sequence ID" value="CUO21066"/>
        <property type="gene ID" value="ERS852478_02149"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ00094">
        <property type="protein sequence ID" value="CUQ00094"/>
        <property type="gene ID" value="ERS852523_03570"/>
    </dbReference>
    <dbReference type="GeneID" id="64114164"/>
    <dbReference type="GeneID" id="66578997"/>
    <dbReference type="eggNOG" id="ENOG5032RP2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO21066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUQ00094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="73" mass="8008" checksum="F1C5E8BE5E72A9B8" modified="2016-09-07" version="1">MNFGQNLYNWFLSNAQSLVLMAIVVIGIYLGFKREFSKLIGFLVVALVAVGLVFNASGVKDVLLQLFNKIIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WNX6</accession>
    <name>A0A173WNX6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidinol dehydrogenase</fullName>
            <shortName evidence="4">HDH</shortName>
            <ecNumber evidence="4">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 11" type="primary">hisD</name>
        <name evidence="11" type="ORF">ERS852478_00017</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5 10">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199467.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000162.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41203">
        <property type="protein sequence ID" value="CUN41203"/>
        <property type="gene ID" value="ERS852478_00017"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="1 4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 9" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 6">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 8">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 8 9">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN41203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="434" mass="47160" checksum="DBC67DEC1C058668" modified="2016-09-07" version="1">MRTVKLTKESTKDILENLLKRSPNNYGKFESTVAQILDKVKNEGDAALFAYTKEFDKADVTKETIRVTDAEIEEAYAQIDPALLGVIRKALVNIRQYHEKQIQNSWFTSTTDGTMLGQKVTPLNRVGVYVPGGKAVYPSSVLMNIVPAKVAGVPHIVMTTPPGKDGKVCASTLVAAKEAGADEIYKVGGAQAIGALAFGTESIPKVDKIVGPGNIFVALAKKAVYGYVSIDSIAGPSEILVLADETANPHFVAADLLSQAEHDELACAILITTSEEFAKKVDEEVKGFVEVLSRKEIIQKSLDNFGYILIAEDMDEAIEAANEIAPEHMEIVTANPFEDMMKVKNAGAIFIGEYSSEPLGDYFAGPNHVLPTNGTAKFFSALSVDDFIKKSSIVYYSKSALRNIHKDIIQFATSEQLTAHANSIAVRFEDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WPK9</accession>
    <name>A0A173WPK9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199474.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN41472">
        <property type="protein sequence ID" value="CUN41472"/>
        <property type="gene ID" value="ERS852478_00027"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50340RC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN41472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="87" mass="10408" checksum="1D40DEDCEDE82B6C" modified="2016-09-07" version="1">MNKMNELCEMELTGRYEEKFSALKAEISVADEYIRQDNSDLTEFENRYERLDIPYRVKRFLDDYIACMQTKYERLADLCYLAGEQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WRH9</accession>
    <name>A0A173WRH9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN40955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199464.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN40955">
        <property type="protein sequence ID" value="CUN40955"/>
        <property type="gene ID" value="ERS852478_00011"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032XN3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN40955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="217" mass="25186" checksum="3956187038E8DBCC" modified="2016-09-07" version="1">MTEKKNRNKKQSKAKTSSRVSKGNFGYFRSEKRRRLIITAILFAVPLFIFFTSWFYFKTRMTVWTVVTVVGCLPACKSMVNLIMILKCRPMDAGLYQKIHEHQGSLDMAYELYMTFYEKSAYIDAAAVCGNTVVAYSSDPKIDASFMEINSQKIIRKNGYKVTVKIFTDFRPFLERLDSMNDHRESLEEGIKFTPDEKYPDLSRNELVRQTILALCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WV80</accession>
    <name>A0A173WV80_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cadmium, zinc and cobalt-transporting ATPase</fullName>
            <ecNumber evidence="6">3.6.3.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cadA</name>
        <name evidence="6" type="ORF">ERS852478_00070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.3" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199487.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN42836">
        <property type="protein sequence ID" value="CUN42836"/>
        <property type="gene ID" value="ERS852478_00070"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00941">
        <property type="entry name" value="CDATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN42836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="621" mass="67319" checksum="9E9C497930988250" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WXG9</accession>
    <name>A0A173WXG9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Manganese transport regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Metal-dependent transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Transcriptional regulator MntR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mntR_1</name>
        <name evidence="8" type="synonym">mntR_2</name>
        <name evidence="8" type="ORF">BWLFYP14_02569</name>
        <name evidence="6" type="ORF">ERS852478_00068</name>
        <name evidence="7" type="ORF">GT712_07565</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="7 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993892.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000079.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN42778">
        <property type="protein sequence ID" value="CUN42778"/>
        <property type="gene ID" value="ERS852478_00068"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUN42778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZS88928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="130" mass="14385" checksum="734B7E792211B5F0" modified="2016-09-07" version="1">MAIHESGEDYLEAILMIKKRNGNVRSIDIAHELSFSKPSVSVAMKNLKASNYITIDENGFINLTETGQEIADKIYERHTFLTGWLTSIGVDPKVAAEDACKMEHAISAESFAAIKKSIAGTHENYSNPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X1L9</accession>
    <name>A0A173X1L9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00126</name>
        <name evidence="2" type="ORF">ERS852523_01864</name>
        <name evidence="3" type="ORF">GT712_00830</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
            <strain evidence="2 5">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP51473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703164.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000078.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44455">
        <property type="protein sequence ID" value="CUN44455"/>
        <property type="gene ID" value="ERS852478_00126"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP51473">
        <property type="protein sequence ID" value="CUP51473"/>
        <property type="gene ID" value="ERS852523_01864"/>
    </dbReference>
    <dbReference type="GeneID" id="66495898"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN44455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP51473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS87669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="65" mass="7657" checksum="6B5483CE74D25848" modified="2016-09-07" version="1">MRCKDCEYVKCYAVNKKMYYCDNRNRVNLMGKLGEDNLPETSPEWCPMADRTIDENNMAEKGLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X209</accession>
    <name>A0A173X209_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">mRNA interferase YafQ</fullName>
            <ecNumber evidence="3">3.1.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yafQ_1</name>
        <name evidence="7" type="synonym">yafQ</name>
        <name evidence="7" type="ORF">BWLFYP14_02622</name>
        <name evidence="3" type="ORF">ERS852478_00124</name>
        <name evidence="4" type="ORF">ERS852523_01866</name>
        <name evidence="6" type="ORF">GT712_00840</name>
        <name evidence="5" type="ORF">GT728_15975</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP51520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000047">
        <property type="protein sequence ID" value="MZL34651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703161.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44388">
        <property type="protein sequence ID" value="CUN44388"/>
        <property type="gene ID" value="ERS852478_00124"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP51520">
        <property type="protein sequence ID" value="CUP51520"/>
        <property type="gene ID" value="ERS852523_01866"/>
    </dbReference>
    <dbReference type="GeneID" id="66495900"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004386">
        <property type="entry name" value="Toxin_YafQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40588">
        <property type="entry name" value="PTHR40588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15738">
        <property type="entry name" value="YafQ_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006156">
        <property type="entry name" value="YafQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN44388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP51520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL34651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS87671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="91" mass="10826" checksum="03F466F20853F103" modified="2016-09-07" version="1">MKYTVKPTSKFQKDLKRIQKRGYDMRLMTDIIKKLANGEILPPKNRDHNLSGNYSNCRECHIAPDWLLIYEVYEDELFLYLTRTGSHSDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X385</accession>
    <name>A0A173X385_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">mutL</name>
        <name evidence="8" type="ORF">BWLFYP14_02640</name>
        <name evidence="7" type="ORF">ERS852478_00142</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379970.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44818">
        <property type="protein sequence ID" value="CUN44818"/>
        <property type="gene ID" value="ERS852478_00142"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="6">
        <location>
            <begin position="209"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="5">
        <location>
            <begin position="497"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN44818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX66268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="683" mass="77701" checksum="EF67823B14ACD7FF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X3X6</accession>
    <name>A0A173X3X6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Carbamate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">arcC1_1</name>
        <name evidence="9" type="synonym">arcC</name>
        <name evidence="11" type="synonym">arcC1_2</name>
        <name evidence="11" type="ORF">BWLFYP14_02686</name>
        <name evidence="7" type="ORF">ERS852478_00190</name>
        <name evidence="8" type="ORF">ERS852523_00347</name>
        <name evidence="10" type="ORF">GT712_00510</name>
        <name evidence="9" type="ORF">GT728_06045</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:10152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate metabolism; carbamoyl phosphate degradation; CO(2) and NH(3) from carbamoyl phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the carbamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000003">
        <property type="protein sequence ID" value="CUP04197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703267.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000134_gene411"/>
    <dbReference type="EnsemblBacteria" id="CUN46030">
        <property type="protein sequence ID" value="CUN46030"/>
        <property type="gene ID" value="ERS852478_00190"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP04197">
        <property type="protein sequence ID" value="CUP04197"/>
        <property type="gene ID" value="ERS852523_00347"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00996">
        <property type="reaction ID" value="UER00366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035975">
        <property type="term" value="P:carbamoyl phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04235">
        <property type="entry name" value="AAK_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="PTHR30409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000723">
        <property type="entry name" value="Carbamate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00746">
        <property type="entry name" value="arcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN46030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP04197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL32779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS87609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX66313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="314" mass="33896" checksum="2AEEB4F8189CCEE6" modified="2016-09-07" version="1">MFTRKRIVIALGGNALGNTLPEQMVAVKTTAKALCDLIEEGHQVVVVHGNGPQVGMINNAMSALSREDENQPNTPLSVCVAMSQAYIGYDLQNALREELRIRGFVRTPVVTVVTQVRVDPNDPAFENPSKPIGKFLTKEEADHQAKAYGHIMKEDAGRGYRRVVASPKPVEIVEQDAINSLVDANKIVICCGGGGIPVVLNGHHLKGASAVIDKDYASCLLAKELDADMLIILTAVEKVAVNFGKENEEWLDDITVDDAKKYINEGQFAPGSMLPKVQAAVDFASSKEGRTAMITLLQKAKDGIQGKTGTKIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XGJ3</accession>
    <name>A0A173XGJ3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multidrug export protein mepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mepA_2</name>
        <name evidence="2" type="ORF">ERS852478_00271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN49488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380201.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000014.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN49488">
        <property type="protein sequence ID" value="CUN49488"/>
        <property type="gene ID" value="ERS852478_00271"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN49488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="447" mass="48891" checksum="2AD4F11BCB91F9FE" modified="2016-09-07" version="1">MSKDEYLITDAPLKALTVFAMPMILGSFFQQVYNMADSIIVGQFVGSSALAAVGACAALTNVFICVALGAGVGAGVLVSRYFGAQNYSKMKTIVSTSLISFLILSILLGVFGFVFSHFMMSLLQTPADILDEAVLYLRVYFVGFPFLFMYNILSTMFNSIGESKIPLGLLIFSSVLNIVMDLWMVAGLGLGVFGAALATLIAQGISAVFSLLIFFNRMRRYKSRFNWFDRQELHSMLRIAVPSVLQQSTVSIGMMIVQAVVNPFGTQALAGYAATMRVENVFSLIFVSIGNAVSPYVSQNLGAKKIERIKKGYHAALVLDLCFAVLAFIVIETLHTPISSLFLGKDGTALAYQVSGDYMKWLGYFFIFMGIKMATDGVLRGLGIMRPFLIANMVNLAIRLSVALIFAPRYGIAFVWLAVPAGWFANFLISYGALRKSWPVDEGVSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XPB4</accession>
    <name>A0A173XPB4_9FIRM</name>
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        <submittedName>
            <fullName evidence="3">YibE/F family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">YibE/F-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00366</name>
        <name evidence="3" type="ORF">GT728_06495</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000011">
        <property type="protein sequence ID" value="MZL32859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199586.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52425">
        <property type="protein sequence ID" value="CUN52425"/>
        <property type="gene ID" value="ERS852478_00366"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012507">
        <property type="entry name" value="YibE_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41771">
        <property type="entry name" value="PTHR41771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07907">
        <property type="entry name" value="YibE_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN52425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="375" mass="40607" checksum="7F2FBA31C1F9B77F" modified="2016-09-07" version="1">MLNKNFLRRGCLVIAGILFLIFLMQYNKIEKTELLSTEGRTFEKAVVTEVISDNLTENGNRVGNQTVRLRLCSGKFKNEKVEAISSSSYLFGATCKKGMKVIALVSESQGEVIASVYSADREFSLYFMIAVFLLAIILIGGKKGAASVMGLGFTIVCVLFLFLPMIYRGVSPIFSAVVVAVITTVVTIYLISGISVKSLTAISGTVTGVVMAVIFAGIFGKVTQITGYNVSDIEELIYLEEKTAIKINELLFAGILIASLGAVMDVGMSIASTLQEIYSRRPDLGMWDLFKSGMNVGKDMMGTMSNTLILAFAGGSLNTLVFIFAYNYSYHQIINMYSIGIELMQGISASMGVILTVPFTSLAGAFFISGKVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XPC2</accession>
    <name>A0A173XPC2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized N-acetyltransferase YjaB</fullName>
            <ecNumber evidence="2">2.3.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yjaB_1</name>
        <name evidence="2" type="ORF">ERS852478_00361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52278">
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        <property type="gene ID" value="ERS852478_00361"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0008080">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN52278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="158" mass="18277" checksum="832E44A1C78E6133" modified="2016-09-07" version="1">MTIRKAEEKDILRIIELLGQVLQIHADIRPDIFIPGTTKYTVSELTELLGKEEKPIYVAVNEEDVCVGYAFCQLQEQPFSTNMVPFKSLFIDDLCVDQQARGQHIGESLFEYVKNEAKRMGCYEVTLNVWAGNTSAEKFYKKMGMKTKERQMEYILEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XXD7</accession>
    <name>A0A173XXD7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative NTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN56722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199661.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN56722">
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        <property type="gene ID" value="ERS852478_00478"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03266">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN56722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="181" mass="20789" checksum="0C90F7E0917290F6" modified="2016-09-07" version="1">MKWDFTMTQHIFLTGKKHIGKSTLIQKILDDYKKTADGFLTVRTKNYLKDQYSVHMYHLKEKELPNESNLLFLCGKTDEHTADTFDRLGCNILSMCSDCSLIVMDELGPHEADAALFRKKILNLLDGQTPILGVLQEPAESFWPEIVNHPKVEIITISEDNRNDCSLLNHITSIFSDLYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y6W5</accession>
    <name>A0A173Y6W5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_03305</name>
        <name evidence="1" type="ORF">ERS852478_00565</name>
        <name evidence="2" type="ORF">GT712_13340</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000027">
        <property type="protein sequence ID" value="MZS90030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX67028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706201.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN59433">
        <property type="protein sequence ID" value="CUN59433"/>
        <property type="gene ID" value="ERS852478_00565"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN59433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZS90030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX67028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="124" mass="14634" checksum="B5F53F7924280C95" modified="2016-09-07" version="1">MYCIAILTDQEQEGQNCAEYIRNYCTEKKVFPLIEIYQNQEQFFGRIRKTVPAVVFLALPGVSGLNAAEHLRSLYPKCGIIWCSDLDFSLHAFRMRIEYFFMKPVEEQKIKEGLSIWFERRNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YD51</accession>
    <name>A0A173YD51_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-Rha:alpha-D-GlcNAc-pyrophosphate polyprenol, alpha-3-L-rhamnosyltransferase</fullName>
            <ecNumber evidence="2">2.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">wbbL_1</name>
        <name evidence="2" type="ORF">ERS852478_00626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN61563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN61563">
        <property type="protein sequence ID" value="CUN61563"/>
        <property type="gene ID" value="ERS852478_00626"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="305"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="558"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN61563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="835" mass="96577" checksum="80B54821EEA285F9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YP55</accession>
    <name>A0A173YP55_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bifunctional xylanase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">xynD</name>
        <name evidence="2" type="ORF">ERS852478_00686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN64568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN64568">
        <property type="protein sequence ID" value="CUN64568"/>
        <property type="gene ID" value="ERS852478_00686"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="68"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN64568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="250" mass="28122" checksum="3D686505C21658B2" modified="2016-09-07" version="1">MKRTLIFFEILCMIFFLLFSSADKRTQFLTSLAGPGMLSLVKQASAKATASENFSTDTTAGLPVEESPRIALTFDDGPNARYTPILLDGLKKRNIRASFFLIGENIEGNEDILLQMRKDGHLIGNHTWDHVQLDKIPAEKARLEIEKTNNRIYEASGIYPSYIRPPFGAWIKDMELSVTMLPVFWDVDTLDWQSKNIDSILSIAQKQVHDGSIILMHDGYQTSVDAALEIADLFTEKGYVFVTADQLLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z2V2</accession>
    <name>A0A173Z2V2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69766">
        <property type="protein sequence ID" value="CUN69766"/>
        <property type="gene ID" value="ERS852478_00836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN69766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="102" mass="10997" checksum="9D150B3AA1106372" modified="2016-09-07" version="1">MFSVLMRAFSFTLIIIIGIVMKSTGFVPKDAGASVKKFLIYVTLPASIITNFSAIEDMGFNMLIIAALGILLNVIMIAVGATDHTQKIQRRTGVKYALSSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z6T5</accession>
    <name>A0A173Z6T5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tadA</name>
        <name evidence="5" type="ORF">ERS852478_00858</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN71389">
        <property type="protein sequence ID" value="CUN71389"/>
        <property type="gene ID" value="ERS852478_00858"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN71389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="165" mass="18351" checksum="0FD9028357522B66" modified="2016-09-07" version="1">MKEAIRQAKKAEALEEVPIGCVIVHEGKIIARGYNRRNTDKNTLSHAELNAIRKASKKLGDWRLEGCTMYVTLEPCQMCSGALVQSRIDEVVIGCMNAKAGCAGSVMNLLQVDGFNHQVKIMQGVLEEECSSMLSEFFRKLREKKKQEKAALKAAQENPEGEPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZAU4</accession>
    <name>A0A173ZAU4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN72308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199837.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN72308">
        <property type="protein sequence ID" value="CUN72308"/>
        <property type="gene ID" value="ERS852478_00891"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZC8M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043756">
        <property type="entry name" value="DUF5702"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18960">
        <property type="entry name" value="DUF5702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN72308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="493" mass="54999" checksum="F0DFB3A4FDD62721" modified="2016-09-07" version="1">MKYCGKERGSITLFLALILSLLLSLVCTSIESVCMASARTQILNSMDIGLYSVFGQYDRKLLEEYDLFALDGSMGGGQLNLAKICDNLESYMKPVLKQNSQKLELHQSGLTGYRLLTDECGEVFYQQIVQYMQETLGSQGVQLLLNKMSDRERKTEEADLKAKQAETGGSIDRYDSEMNQASQKSRQAAQEAENRQQQEGQISTQPAPTQPQADNPISIIKRIMKMGILELVLPPGREISTRTVSKDTMVSGRQLQQGMEMPDGVTADSSYTSGVLFQQYLMNHLGNYTDPSKESLAYQMEYVFGGRDNDIDNLKSVASKLLFIREGVNFACLMADNVKRTEAQALAAAIASGFLVPPAAVVIESALLLCWAFAESVLDVRELFAGGKIPLVKTSADWQISLSNLSSLMEGLDSMRKNNEHGLSYEDYLQVLILPVSKEKKVMRAMDMIEDAIRKKGRANFYMDSCVVALEAFAEVKANRKKEFQVIRQYCYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZB13</accession>
    <name>A0A173ZB13_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-alanine N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199844.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73157">
        <property type="protein sequence ID" value="CUN73157"/>
        <property type="gene ID" value="ERS852478_00919"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="116"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN73157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="258" mass="29979" checksum="71ECAE85F45D38CF" modified="2016-09-07" version="1">METTIKQIEDMSLNAWPSHKMELYDGWILRFSYFYTHRTNSVEQFGNSTLTWREKIPYCESVYKRLGTPAVFKISPLVSPDFDYVLENRGYAIQHTTNVMAMSMNAARLDTPYPDVTFCDNIPSEWIESLFRLKNTTNPIHRKVVPSMYQAILKETICASIRMDNQIIATGLGILDRDYIGIYAIHVKEEYRKHGYARQICTGLLKEGMKKGAQNAYLQVVEGNDNARVLYKSLGFHQLYTYWFRVQPDENGNFPPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZCF3</accession>
    <name>A0A173ZCF3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function DUF45</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053344.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000007.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73687">
        <property type="protein sequence ID" value="CUN73687"/>
        <property type="gene ID" value="ERS852478_00937"/>
    </dbReference>
    <dbReference type="GeneID" id="66493052"/>
    <dbReference type="eggNOG" id="COG1451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="76"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN73687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="195" mass="23300" checksum="9ACFAE44FD0920FF" modified="2016-09-07" version="1">MDMDKTEKNQEKFTCGEFEYQVIRSARKTMTLEVRRDGNVIVRAPLRTGLPRIKRFVNQKQEWVLGCLERTKEYREQKPLSADLSESKRNVYIRKAKETITKRVSYFARLMGVSYRNITIREQKTRWGSCSSEKNLNFNWKLILAPPEVLDYVVVHELCHLKEMNHSKAFWDEVGKVMPEYETYKLWLKENGWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZCW2</accession>
    <name>A0A173ZCW2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Antiholin-like protein LrgA</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">CidA/LrgA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lrgA</name>
        <name evidence="9" type="ORF">BWLFYP14_01303</name>
        <name evidence="7" type="ORF">ERS852478_00932</name>
        <name evidence="8" type="ORF">GT728_01340</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN73509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993269.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN73509">
        <property type="protein sequence ID" value="CUN73509"/>
        <property type="gene ID" value="ERS852478_00932"/>
    </dbReference>
    <dbReference type="GeneID" id="66493047"/>
    <dbReference type="eggNOG" id="COG1380">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005538">
        <property type="entry name" value="LrgA/CidA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33931">
        <property type="entry name" value="PTHR33931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03788">
        <property type="entry name" value="LrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN73509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL31876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="VUX64239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="122" mass="13485" checksum="18F32FD948C7823C" modified="2016-09-07" version="1">MKYVRQFWIILLISAMGEALHVLIPLPVPASVYGLVIMLIALGTHIIRLEQVKEAAEFLIEIMPVMFIPAGVGLLTAWGILKPVCVPIILITVITTVVVMIVTGRVTQAVIRMDRKKGQKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZFE6</accession>
    <name>A0A173ZFE6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted AAA-ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
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    </dbReference>
    <dbReference type="RefSeq" id="WP_055059458.1">
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    <dbReference type="EnsemblBacteria" id="CUN73845">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PDDEXK_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09820">
        <property type="entry name" value="AAA-ATPase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDDEXK_9"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="17"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN73845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="529" mass="60957" checksum="C6292F8F3DC83489" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZG01</accession>
    <name>A0A173ZG01_9FIRM</name>
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        <submittedName>
            <fullName evidence="3">MurPQ operon repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">murR</name>
        <name evidence="3" type="ORF">ERS852478_00984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199871.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75164">
        <property type="protein sequence ID" value="CUN75164"/>
        <property type="gene ID" value="ERS852478_00984"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="116"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN75164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="275" mass="31567" checksum="EBADBA45B4F4624C" modified="2016-09-07" version="1">MSLSKRKIIPLIESYYHTFTPLERTIADFFMHNTEEEDLSSRHISGILYVSEASLSRFAQKCGFHGYREFIYEYKQSLTPETEENVPNFEISEFNTYQELLNKANALLDKAQIARITKLLVSRPRVYVYGRGSSGLVAQEMKLRFMRIGLNIEAVTDSHIMKVNSVILDESCLVIGISVSGQTADIISSLKAAHQRGAYTLLMTARQDKSYQEFCDETLIFASMEHLEYGNIISPQFPILLVLDVLYAHYLQIDRSKKEALHEYTIQTLQPFLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZG69</accession>
    <name>A0A173ZG69_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="7">3.2.1.99</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">abnA</name>
        <name evidence="7" type="ORF">ERS852478_00990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199875.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000005.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75392">
        <property type="protein sequence ID" value="CUN75392"/>
        <property type="gene ID" value="ERS852478_00990"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Abn2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
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        <property type="entry name" value="GH43_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008016849" evidence="5">
        <location>
            <begin position="25"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="GH43_C" evidence="6">
        <location>
            <begin position="412"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN75392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="524" mass="58580" checksum="C98255995A9EB0F8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZL36</accession>
    <name>A0A173ZL36_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RES domain</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">RES domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01006</name>
        <name evidence="3" type="ORF">GT728_13515</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000034">
        <property type="protein sequence ID" value="MZL34195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707124.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75938">
        <property type="protein sequence ID" value="CUN75938"/>
        <property type="gene ID" value="ERS852478_01006"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z9NV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014914">
        <property type="entry name" value="RES_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08808">
        <property type="entry name" value="RES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00953">
        <property type="entry name" value="RES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RES" evidence="1">
        <location>
            <begin position="193"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN75938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="360" mass="41871" checksum="81DCE2E71CAD79D2" modified="2016-09-07" version="1">MQIGLECFLDEQLSSMIASENRHGDCEIQHKTDCIIYDTEEDHYLEEYLEEIMDAFTVAKHLKVAESDVRADYLKNFLSKWKVFSVTGDDIQQIITAICSERYQDEPELFDKKVTIREFFSADTMEQQCILKTYNWDDFCYNIKHVNRFHSQQVNFDQLENLLKNMVIDIPKGTLKLFRSRICDEDSYTSGYSTRKMGVPPVALTTAGRTNSEGIQCLYLAGDEETTFHEVRARDYDHVSVGEFIQTKDLRIVDLSLFDKIGPFSIPDFDMTWFAINIEIIRKIGDEVAKPMRRFDRALDYVPTQYICDYIKHLGYDGIKFKSTLVDGGTNYAIFNEKKFECTNVKVVQIGNIDYNWSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZRB9</accession>
    <name>A0A173ZRB9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78209">
        <property type="protein sequence ID" value="CUN78209"/>
        <property type="gene ID" value="ERS852478_01046"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="13"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN78209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="217" mass="24341" checksum="5F80A535695457FE" modified="2016-09-07" version="1">MSKKITKRGRYIMKVLMLNGSPRTKGNTFIALEEMKKVFEVEGVEAEIVQVGNKDVRGCIACRRCVELGKCVFDDVVNELAPKFEEADGIVVASPVYFASANATLIATLDRLFFSTSFDKTMKVGASVVCARRGGCSATFDELNKYFTISNMPIAASQYWNCIHGRELGEADRDEEGKQTMRVLARNMIFLMKSIELGKKQFGLPEKEEHAFTHFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZT94</accession>
    <name>A0A173ZT94_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199915.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79491">
        <property type="protein sequence ID" value="CUN79491"/>
        <property type="gene ID" value="ERS852478_01082"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012507">
        <property type="entry name" value="YibE_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41771">
        <property type="entry name" value="PTHR41771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07907">
        <property type="entry name" value="YibE_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN79491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="366" mass="41357" checksum="CA86761B541F8391" modified="2016-09-07" version="1">MKSHVFQMKYFLAGIYIICVIFTCFNARFYHTPLAKISSVTEKETMSRKGTRDAEEYYYTQKITARILNGTHKGEEISISNEYTSSQVQNQKYHKGDTVLLSGSRENPGKSIRSIKRDGYLALLAGGLFFLLICITGKQGFYTIISLILNTIIFAFGFQAFMKGENILNICNVIAFLFSITTLICLNGIHRKTWASVISTICVLFLIMALFEFSIQFFGDLDYSNLEYLGSMSNSADIFWTDIMLTGLGAIMDVAVTISAATGEIVRKNPDVSLRKLIHSGREIGYDIMGTMINVLLFVLASSMILMFILKMNNEIRFITIIRYHIPYDICRFLIESIGIVLAIPVSVFISSIIMKLPFLKRSDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZXB1</accession>
    <name>A0A173ZXB1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator FixK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN80046">
        <property type="protein sequence ID" value="CUN80046"/>
        <property type="gene ID" value="ERS852478_01098"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN80046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="230" mass="25689" checksum="02B0242C9C894E23" modified="2016-09-07" version="1">MKKYLPILKNSPFFTGLTDNEILSILHCVKATAVSQKRDSYIFRAGDSTEVMGLVVSGCVLVIQEDLWGHRNILSKCHTGDFFGEPYAASPGAVLNVSVVADTDCEIILLNVQRLLISCPTACEHHQKLIRNLVSVLANKILILNDKITHVGKRTTRDKLLSYLSAESISHSSLSFDIPFDRQQLADYLCIDRAAMSTEISKLQKEGYIKTNRNHFELTVCNNSDSEIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZXG4</accession>
    <name>A0A173ZXG4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN79868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019162386.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN79868">
        <property type="protein sequence ID" value="CUN79868"/>
        <property type="gene ID" value="ERS852478_01093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008017254" evidence="1">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN79868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="144" mass="16312" checksum="BCE57CC70D9F71E1" modified="2016-09-07" version="1">MKKKSISVICAVLVISGVATVLVLTGNRGNVSNVNRVVGYSALYGENSINEAFDVIEKKFAKDFKGCTLAELRYDEDVENRFAEEIEKYHKENNQELIVVLSIFDTDEKGGDGGFNPNDTYANWQWYLVKTADKKSWEIINWGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZY24</accession>
    <name>A0A173ZY24_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylosuccinate synthetase</fullName>
            <shortName evidence="7">AMPSase</shortName>
            <shortName evidence="7">AdSS</shortName>
            <ecNumber evidence="7">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">purA</name>
        <name evidence="8" type="ORF">ERS852478_01109</name>
        <name evidence="9" type="ORF">ERS852523_00431</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
            <strain evidence="9 11">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN80480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP06567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704193.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000003.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000045_gene2072"/>
    <dbReference type="EnsemblBacteria" id="CUN80480">
        <property type="protein sequence ID" value="CUN80480"/>
        <property type="gene ID" value="ERS852478_01109"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP06567">
        <property type="protein sequence ID" value="CUP06567"/>
        <property type="gene ID" value="ERS852523_00431"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
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</entry>
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        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
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                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 5">BIOML-A12</strain>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007211">
        <property type="entry name" value="DUF378"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37304">
        <property type="entry name" value="PTHR37304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04070">
        <property type="entry name" value="DUF378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN89983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS90860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="71" mass="7715" checksum="A19642B8D18FAF32" modified="2016-09-07" version="1">MGSKCLRYTALTIAIIGAVNWGLIGFFNLNLVALLFGSMSWVSRIVYGLVGICGLYLLTFYGDSDTISEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AZS4</accession>
    <name>A0A174AZS4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200087.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94087">
        <property type="protein sequence ID" value="CUN94087"/>
        <property type="gene ID" value="ERS852478_01440"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN94087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="144" mass="16525" checksum="DB05ED77F1EC1247" modified="2016-09-07" version="1">MAGTYTYEPAMITSYGKDRMRFELGDVMVDGRERTCALSDEEYIVLCDDVQSAKDWKRAKLKCLESIFRRFSFEPDTTVGPTSFKFGDRAKLWQEEYEALRKELRLASVSPSAILMNAGDMSKQPPPYFYNGMMSHEESEGDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BAB8</accession>
    <name>A0A174BAB8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">feoB_2</name>
        <name evidence="16" type="synonym">feoB</name>
        <name evidence="17" type="synonym">feoB_1</name>
        <name evidence="17" type="ORF">BWLFYP14_00967</name>
        <name evidence="15" type="ORF">ERS852478_01511</name>
        <name evidence="16" type="ORF">GT712_12995</name>
    </gene>
    <organism evidence="15 18">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="15 18" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 18">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="16 20" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 20">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="17 19" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000026">
        <property type="protein sequence ID" value="MZS89963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993852.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000018.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96608">
        <property type="protein sequence ID" value="CUN96608"/>
        <property type="gene ID" value="ERS852478_01511"/>
    </dbReference>
    <dbReference type="GeneID" id="66492591"/>
    <dbReference type="eggNOG" id="COG0370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041069">
        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="715"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="14">
        <location>
            <begin position="115"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CUN96608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZS89963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VUX63481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="777" mass="85211" checksum="9C65951B558675F1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BCL5</accession>
    <name>A0A174BCL5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003509287.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97510">
        <property type="protein sequence ID" value="CUN97510"/>
        <property type="gene ID" value="ERS852478_01534"/>
    </dbReference>
    <dbReference type="GeneID" id="61119851"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025464">
        <property type="entry name" value="DUF4315"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14193">
        <property type="entry name" value="DUF4315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN97510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="85" mass="9574" checksum="1334844F6E3CB56A" modified="2016-09-07" version="1">MAMNKLERIEKDIEKTKGKIAELQKQLRELEAAKTEQENLQIVQLVRGLNMTPQEFAAFVRGGALQAAPAPIPDFEQEDSAHEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BJ66</accession>
    <name>A0A174BJ66_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057307.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000024.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00239">
        <property type="protein sequence ID" value="CUO00239"/>
        <property type="gene ID" value="ERS852478_01590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045798">
        <property type="entry name" value="TrbL_Firmicutes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19478">
        <property type="entry name" value="TrbL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO00239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="289" mass="31898" checksum="98BACB3BB9B729A4" modified="2016-09-07" version="1">MNTIIERITEAIKDILIGLIKSCLDNMFTSVNEQVGTIAGQVGQTPQGWNAGIFNLIQNISQTVIVPIAGLIITFVLCYELITMVTQKNNFHEFETYNIFLWIFKAYVAIYLVTNTFNITMAVFDVGQHVVNNAAGVISGNTAVDATEAITRIVDALEDMELGDLFLLSMETLLISITMRILSIIITVILYGRMIEIYLYTSIAPIPFATMTNKEWGNIGNNYLKGLFALAFQGFFMMVCVGIYAVLVNAMTISSDLHAAMFSVAAYTVILAFSLFKTGSLSKSIFNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C3E4</accession>
    <name>A0A174C3E4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromate transporter</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">Chromate transporter, chromate ion transporter (CHR) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_01745</name>
        <name evidence="9" type="ORF">GT712_12140</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO06236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200217.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO06236">
        <property type="protein sequence ID" value="CUO06236"/>
        <property type="gene ID" value="ERS852478_01745"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO06236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="187" mass="19714" checksum="D59A7485E545A09C" modified="2016-09-07" version="1">MIYLQLFLSFLQIGLFSFGGGYAAMPLVQGQVVTAHGWLSMSEFTDLITISQMTPGPIAVNSATFVGIKIAGIPGALIATLGCILPSCIIVTVIAKLYLKYREMDMLQGVLNSLRPAVVAMIASAGISILITAFWGSSASIALAGTKWSLVVIFAICVVLLQKVKMNPIWVMVAAGVMKVAISFLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CAI8</accession>
    <name>A0A174CAI8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10462">
        <property type="protein sequence ID" value="CUO10462"/>
        <property type="gene ID" value="ERS852478_01855"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO10462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="187" mass="21431" checksum="0AF0F25DA04BF732" modified="2016-09-07" version="1">MSRCGRGGGVYEYVQREFAYNEGRLDGGELSKQNIISMFESGLIYANEGEMMFRAEDIINADRHFAALQYAITQCIYSLSGGDIQEIQMRLGAGQNIPGNIEEQPKTLRDIAVFHIEWIKAGSDAKTARILAFMQCLQADIAPFIIRVENKEEYEGRLDSPARLEQFFRVEQRRFYRETEPMVIDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CBQ1</accession>
    <name>A0A174CBQ1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trxA_2</name>
        <name evidence="4" type="ORF">ERS852478_01861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10634">
        <property type="protein sequence ID" value="CUO10634"/>
        <property type="gene ID" value="ERS852478_01861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="2"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO10634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="44" mass="5115" checksum="DCC199793B49A58E" modified="2016-09-07" version="1">MLTITTNSFDNDVLHADKPELVDFWAQWCPYCRRIAPAFDKVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CDH8</accession>
    <name>A0A174CDH8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200360.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10319">
        <property type="protein sequence ID" value="CUO10319"/>
        <property type="gene ID" value="ERS852478_01850"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO10319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="128" mass="14427" checksum="554F96B765FE4B50" modified="2016-09-07" version="1">MRHPQYVRTGNLWAVTEPVTGKLAPAEQTEADIDITYNYSRYYYEATDGDIWFAHEDVSAYHADETQGPAETEYGIRGLYGSTSAESIPMLMDMIVMATNCLMGKDIVWSGGLKKRRAQCFSFLIVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CDP8</accession>
    <name>A0A174CDP8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO09858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200335.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO09858">
        <property type="protein sequence ID" value="CUO09858"/>
        <property type="gene ID" value="ERS852478_01836"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO09858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="103" mass="11808" checksum="0A84E8500C951F98" modified="2016-09-07" version="1">MNEYVRYMNMRYEMAECAEVTRQVLGLTVPVSLETLMEAMKKAGIQCVPDESLDTDTRIVELPENPEYAFQVLYSIKINDRSLIFCLASALGEILLHRLNFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CEJ9</accession>
    <name>A0A174CEJ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein, YkwD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_01842</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO10046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200341.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO10046">
        <property type="protein sequence ID" value="CUO10046"/>
        <property type="gene ID" value="ERS852478_01842"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013378">
        <property type="entry name" value="Listeria/Bacterioides_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042229">
        <property type="entry name" value="Listeria/Bacterioides_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02543">
        <property type="entry name" value="List_Bact_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008019104" evidence="2">
        <location>
            <begin position="36"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="36"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO10046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="481" mass="52832" checksum="958F545CE896CA9C" modified="2016-09-07" version="1">MDTVNIKKYFYQILSIFAALLLSFSIAQIPVQAAAKPGTVKLSSIKAVDYNKINIKWKKTSGATNYIVYYKKAGGKKWIKVKTLDNKKTNYTHTSSSKYPIVVGQKYTYTVKAYNKKTKKSGRYSKTGLTTRTVPATVYGLGAGLTGDNTVNVSWNPAGGTTHYVIYRKANDSAPSKIATISSKYTRYEDKNPVEGVTNTYFVFGYSSKFKVYGDGSNTGVSIKVKKKVTPTPEPTSKPEKPGDNNNDNNHGDNDDDFDDPVDPIAMASEVLRLTNIERAKEGAQPLKYNKALQDAAMLRAKEISVKFSHTRPNGTDSSTVGKDVGAGGICGENIAMGQDSPETVVTDWLNSPGHRIPMMRNANQYMGVGFYKAANGIYYWVQEFTEMNPNLLGSITFNANGGTINGKETYTITGTAGTYAWFYDAPSPSDIIDTPTPLKDGYTFSGWYDTPTPSSSRLPLRRVVYGKNGNTVYAKWVPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CU55</accession>
    <name>A0A174CU55_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200488.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16723">
        <property type="protein sequence ID" value="CUO16723"/>
        <property type="gene ID" value="ERS852478_02030"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO16723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="305" mass="35723" checksum="6DE7C2B43F4F28D0" modified="2016-09-07" version="1">MNNTIFDDVFRTMIEKMPYLAVPLINEVFHTSYPEDVKITQLRNEHQQEDGEIITDSCLLIGRKMYHIECQSTDDMTMVIRMIEYDFAIGIEHAEKQGRRYRIEFPKSCVLFLRSSENTPDYLEADVVFPDGNTYLYSIPAIKMADYTKDSIFEKNLLMLLPFYIMRYEKKGHDFNNNPELFQMLLNEYEDIRVNLEKELTETGKSELYTDLTKLIVKIADYIFRKEEDVRKGIGDIMGGKVLELESERLKAEGRTEGEAIGQARGETRLGSLITRLLQDQRTEEIPIVSTDAKRREQLYKEYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CV06</accession>
    <name>A0A174CV06_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200477.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15929">
        <property type="protein sequence ID" value="CUO15929"/>
        <property type="gene ID" value="ERS852478_02006"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033SSD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO15929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="194" mass="22476" checksum="401D1022E99DCBB2" modified="2016-09-07" version="1">MTDTPTIALYYREHDPMKRKMFLDQSIAAGEDEEANAVRKELWELRYGEPSEAGSGTRADGYLALWMAMEYSKDTAGKLFGLKRARKEIEKNLARLKFREMQEKSELHRELLYRECCHMVKTYMELCEKDKAYNTILCGIVHISEKSAKSKIQNDIYTTAIAFPEEINMQEELEMITRAAREVYEAHFPGEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CVC0</accession>
    <name>A0A174CVC0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sodium/proline symporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Proline permease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">putP</name>
        <name evidence="9" type="ORF">ERS852478_02008</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the sodium-dependent uptake of extracellular L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28967"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16049">
        <property type="protein sequence ID" value="CUO16049"/>
        <property type="gene ID" value="ERS852478_02008"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005298">
        <property type="term" value="F:proline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031402">
        <property type="term" value="F:sodium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015824">
        <property type="term" value="P:proline transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11475">
        <property type="entry name" value="SLC5sbd_PutP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011851">
        <property type="entry name" value="Na/Pro_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02121">
        <property type="entry name" value="Na_Pro_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO16049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="511" mass="54377" checksum="5B6C2696F1D3A5D6" modified="2016-09-07" version="1">MSGTTMVILSAFVAYLLIMIVIGVVYMKKTSSSEDYFLGGRGLNAWVAALSAQASDMSGWLLMGLPGAIYSLGTGQIWIAVGLFIGTVLNWVCISHRLRKYTIAANNSLTIPAFLENRFQDKKRILLLLSSIVIVIFFLVYTASALAAGGKLFNTVFGIDYHIALAIGAAVILCYTFMGGFMAVCVTDFVQGTLMLIGLLIVPLVAYFTLSGSLSDLLTQSGAPGGAAAFLNPFENGERPYTFVEIFSQLAWGLGYCGMPHILTRFMAVKSEKELKKSSAIAIVWDILSLTAACFIGIIGRAYLLPTVLGENGASSSESVFIEMINKLFSSHLGLPFIGGIFLCGILAAIMSTADSQLLVTASAASEDLYHQFIKKDADSKEILAVARLTVIVVSVLAFVIAWNPNSSIMGLVSNAWAGLGAAFGPTVVMSLFWRRTNLAGAVAGIVSGGLTVIVWDYIPFVAGQTLGSYTGLYSLAVGFAVSLAMIIIFSLATKAPSKEITDVFDKVTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CXL9</accession>
    <name>A0A174CXL9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 9">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">infB</name>
        <name evidence="12" type="ORF">ERS852478_02023</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8 9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16515">
        <property type="protein sequence ID" value="CUO16515"/>
        <property type="gene ID" value="ERS852478_02023"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0532">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="447"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="50"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-domain" evidence="8">
        <location>
            <begin position="450"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="104"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="456"/>
            <end position="463"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="502"/>
            <end position="506"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="556"/>
            <end position="559"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO16515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="946" mass="103645" checksum="25291BEDB0AB87E4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D8V8</accession>
    <name>A0A174D8V8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Choloylglycine hydrolase</fullName>
            <ecNumber evidence="4">3.5.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cbh_2</name>
        <name evidence="4" type="ORF">ERS852478_02131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C59 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.24" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO20480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005347230.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO20480">
        <property type="protein sequence ID" value="CUO20480"/>
        <property type="gene ID" value="ERS852478_02131"/>
    </dbReference>
    <dbReference type="GeneID" id="66495354"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045302">
        <property type="term" value="F:choloylglycine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBAH" evidence="3">
        <location>
            <begin position="2"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO20480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="325" mass="36886" checksum="5AFF26995440943F" modified="2016-09-07" version="1">MCTAATYKTKDFYFGRTLDYEFSYGDQIVITPRNYAFNFRHVGDMKNHYAIIGMAHVAEDYPLYYDAMNEKGVAMAGLNFVGNAVYAAIKPDVENIAQFEFIPWILSQCSSLVEVRELLERINIVNTPFSEQLPLAQLHWIISDENESITVESMSDGLHIYDNPVGVLTNNPPFPQQMFQLNNYMYLSPKQPRNTFCENLALDAYSRGMGGLGLPGDLSSSSRFVRVAFTKVNAISGESEEESVSQFFHILGSVDQQRGCCEVADGKYEITLYTSCCNVTKGIYYYNTYENHQISAVDMHVENLDSDKMICYPVIQGERINYQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DD35</accession>
    <name>A0A174DD35_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type transport system involved in multi-copper enzyme maturation, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200607.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21960">
        <property type="protein sequence ID" value="CUO21960"/>
        <property type="gene ID" value="ERS852478_02178"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025699">
        <property type="entry name" value="ABC2_memb-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13346">
        <property type="entry name" value="ABC2_membrane_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO21960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="287" mass="31667" checksum="BB7FDCF9DDF0998E" modified="2016-09-07" version="1">MTAIYKRELKSYLTSMVGYLFIFFILVLTGIYFSAYQLSATYPKFEYTLSAITFAFLIGVPILTMRVLAEERKQKTDQLLLTAPVSVSGIVIGKYLALVTVFAVPMAVMCTYPLIMSKFGTVEFASAYTAVLGFFLLGCANIAIGVFMSALTESQVIAAVLTFVFLFAFYMMNGISSFFSQTSMSTCVTFGLLILAAAIIIYTMIKNILISAVIGVIGEVALIIIYVVKSSIFEGGIQKVLDVFNLSGHFDNFTSNIFDIKGIVYFLSVIAVCLFLTTQSILKRRWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DE42</accession>
    <name>A0A174DE42_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yidD</name>
        <name evidence="4" type="ORF">BWLFYP14_02846</name>
        <name evidence="2" type="ORF">ERS852478_02185</name>
        <name evidence="3" type="ORF">ERS852523_01713</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO22196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000015">
        <property type="protein sequence ID" value="CUP46855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000060">
        <property type="protein sequence ID" value="VUX66471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008708006.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO22196">
        <property type="protein sequence ID" value="CUO22196"/>
        <property type="gene ID" value="ERS852478_02185"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP46855">
        <property type="protein sequence ID" value="CUP46855"/>
        <property type="gene ID" value="ERS852523_01713"/>
    </dbReference>
    <dbReference type="GeneID" id="66493377"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO22196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP46855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="70" mass="8078" checksum="C8CD12EE0F7A6C6B" modified="2016-09-07" version="1">MIKKFLIRIIKLYQKYISPMKRTKCPYIPTCSQYGLEAIEKYGALKGGLLAVWRILRCNPFSHGGYDPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DLL1</accession>
    <name>A0A174DLL1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cob(I)yrinic acid a,c-diamide adenosyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_02308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.17" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO26502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705565.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000029.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO26502">
        <property type="protein sequence ID" value="CUO26502"/>
        <property type="gene ID" value="ERS852478_02308"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="Haem_degrading"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="SSF143744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="4">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO26502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="360" mass="39390" checksum="F48449C77FEEEBA5" modified="2016-09-07" version="1">MSIYTKRGDRGITDMAHVGNISKSDDRIRLMGEADELNSHIELVKSMLRQSEILQFLERIQKNLDLIAAGVSNPYDRDCKVSEKETAVLEAETDKLEALCEKPVPEKFTGKSRLAAEIDIARTVARRTERCLAQVSVKFGADTESKRFLNRLSDYLYILARYIEYYSDLSVELSDDHAGALAKTSDNNTDALPEPSDSNTDVLKKTADINEAVIQEVLKRMGIQSRITLDTAKKLIERLEQEAVRRGQRAVIAVCNPEGNPVAVHVMDGAFLVSFDVAMKKAYTAVAVKMSTMELSKIAQPGGTFYGVDKLDGGKIVIFGGGIPLKSGNTIIGGLGISGGTGEEDHSLAEYGQSVLNEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DP85</accession>
    <name>A0A174DP85_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Papain family cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_02326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO27027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO27027">
        <property type="protein sequence ID" value="CUO27027"/>
        <property type="gene ID" value="ERS852478_02326"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4870">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008020138" evidence="2">
        <location>
            <begin position="27"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="572"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO27027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="758" mass="83937" checksum="C6D35AF671C8A15A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DW35</accession>
    <name>A0A174DW35_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rqc2 homolog RqcH</fullName>
            <shortName evidence="1">RqcH</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rqcH</name>
        <name evidence="4" type="ORF">BWLFYP14_02929</name>
        <name evidence="3" type="ORF">ERS852478_02346</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with stalled 50S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000072">
        <property type="protein sequence ID" value="VUX66653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059422.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000015.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO28255">
        <property type="protein sequence ID" value="CUO28255"/>
        <property type="gene ID" value="ERS852478_02346"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00844_B">
        <property type="entry name" value="RqcH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043682">
        <property type="entry name" value="RqcH_bacterial"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="2">
        <location>
            <begin position="461"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO28255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="581" mass="65970" checksum="FD40EC93CE41D84A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DW75</accession>
    <name>A0A174DW75_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acid-resistance membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_00152</name>
        <name evidence="2" type="ORF">ERS852478_02383</name>
        <name evidence="4" type="ORF">GT712_04565</name>
        <name evidence="3" type="ORF">GT728_02125</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 9">BIOML-A1</strain>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000003">
        <property type="protein sequence ID" value="MZL32030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000006">
        <property type="protein sequence ID" value="MZS88384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000067">
        <property type="protein sequence ID" value="VUX66599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29457">
        <property type="protein sequence ID" value="CUO29457"/>
        <property type="gene ID" value="ERS852478_02383"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5033QUA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO29457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="178" mass="19042" checksum="995CF59C3A2F817A" modified="2016-09-07" version="1">MKDNKTLKIIILITGILTVLLGIYTLVRPMRTFLSIGWILGILLFVNGIELVALSLSKEKKEIGACILGVLEGLAGLVLLFSGIQRFITDVMAAYMVGAVILIYGIFQIVGGIKTYSTSKGKGILSIICGILSVIVSIVSFTHPVLTMISAGYMIAFSVLMQGINMIVLGINFGKAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DYE1</accession>
    <name>A0A174DYE1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lytR_1</name>
        <name evidence="8" type="ORF">ERS852478_02372</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO29105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200720.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO29105">
        <property type="protein sequence ID" value="CUO29105"/>
        <property type="gene ID" value="ERS852478_02372"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="130"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO29105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="240" mass="27520" checksum="3991C149F44F5A5F" modified="2016-09-07" version="1">MKIAILDDSKEDLRQIKSVISSYYESLNTSADIRLYSSAESFFAKYSPGFYDLIIMDIYMGTMTGMDAARKLRDAKDTAALIFITSSDAYAVESYDVQASYYLMKPFDPEKLCRILSTIQLRQSQNSRYIELISDRTPVKIPVRSILYVDTYRNAIQVHTTDAGIIRSYMTFQKFEEILDGMKCFLSCYRGCIVNMDHIEEITGEGFLMDSKELVTVRKRGSNAIKKAYLEYLFSSDSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EFQ3</accession>
    <name>A0A174EFQ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 19" type="primary">pheT</name>
        <name evidence="19" type="ORF">ERS852478_02605</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_026648181.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36742">
        <property type="protein sequence ID" value="CUO36742"/>
        <property type="gene ID" value="ERS852478_02605"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="40"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="417"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="712"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CUO36742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="805" mass="89161" checksum="EB4D15D2C581123E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EHX5</accession>
    <name>A0A174EHX5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fe(3+) ions import ATP-binding protein FbpC</fullName>
            <ecNumber evidence="5">3.6.3.30</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fbpC_2</name>
        <name evidence="5" type="ORF">ERS852478_02571</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.30" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO35825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380775.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITH010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO35825">
        <property type="protein sequence ID" value="CUO35825"/>
        <property type="gene ID" value="ERS852478_02571"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO35825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="195" mass="22045" checksum="7F4F91D846A88579" modified="2016-09-07" version="1">MDIKVDHISKAYGEQQVLQDLSCVFPEGKTTCIRGRSGCGKTTLIRLLLRLDVPDKGKIEGVSDRKLSAVFQEDRLCENLSAASNIRLVCTETITDRELEEAYKAVALTEVWQKPVRELSGGMRRRVSILRALLAESDCVIMDEPLRGLDEKTRAKTIDYILKKTEGKTLIFVTHEEKEAVWLKADRTVDILTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ELI5</accession>
    <name>A0A174ELI5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized ABC transporter ATP-binding protein YheS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">yheS_4</name>
        <name evidence="7" type="ORF">ERS852478_02617</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO37075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200804.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000017.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO37075">
        <property type="protein sequence ID" value="CUO37075"/>
        <property type="gene ID" value="ERS852478_02617"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="3"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="328"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="360"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO37075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="636" mass="72429" checksum="4D33A120233D5716" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ER38</accession>
    <name>A0A174ER38_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved virulence factor B</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">S1 RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cvfB</name>
        <name evidence="7" type="ORF">BWLFYP14_00914</name>
        <name evidence="3" type="ORF">ERS852478_02651</name>
        <name evidence="4" type="ORF">ERS852523_02298</name>
        <name evidence="6" type="ORF">GT712_04925</name>
        <name evidence="5" type="ORF">GT728_07025</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CvfB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000018">
        <property type="protein sequence ID" value="CUO38485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000023">
        <property type="protein sequence ID" value="CUP64173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000012">
        <property type="protein sequence ID" value="MZL32958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000007">
        <property type="protein sequence ID" value="MZS88447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000025">
        <property type="protein sequence ID" value="VUX63436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707806.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000031_gene349"/>
    <dbReference type="EnsemblBacteria" id="CUO38485">
        <property type="protein sequence ID" value="CUO38485"/>
        <property type="gene ID" value="ERS852478_02651"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP64173">
        <property type="protein sequence ID" value="CUP64173"/>
        <property type="gene ID" value="ERS852523_02298"/>
    </dbReference>
    <dbReference type="GeneID" id="66492686"/>
    <dbReference type="eggNOG" id="COG2996">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014464">
        <property type="entry name" value="CvfB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039566">
        <property type="entry name" value="CvfB_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040764">
        <property type="entry name" value="CvfB_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37296">
        <property type="entry name" value="PTHR37296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17783">
        <property type="entry name" value="CvfB_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13509">
        <property type="entry name" value="S1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012524">
        <property type="entry name" value="YitL_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="148"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR012524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO38485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP64173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL32958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS88447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX63436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="279" mass="31508" checksum="EAD49F1EBE31F32B" modified="2016-09-07" version="1">MIELGKKQKLTVVKSVDFGVYLGEDMQADAKNRVLLPSRQVPEGTKEGDSIEAFIYKDSQDRLIATTKEPKLQVGQTAVLKVSQVTRIGAFLDWGLEKDLLLPYHEQTLKVREGEDVLVALYIDKSSRLCATMKVYHYLSTRTPYVVGDMVKGRVYEISDRFGVFVAVDDKYSALIPAREAKGKYRPGKILELRVSEVKEDGKMNVTDRQKAYLQINEDAENVLEVINEFAGVLPFDDKASPEVIQREFGLSKGAFKRAIGHLMKEGKVEIKDKRIYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ES98</accession>
    <name>A0A174ES98_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltose-binding periplasmic proteins/domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_019160912.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPH010000045.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40177">
        <property type="protein sequence ID" value="CUO40177"/>
        <property type="gene ID" value="ERS852478_02697"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008021019" evidence="1">
        <location>
            <begin position="28"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO40177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="424" mass="46809" checksum="F5BD448BC84110B6" modified="2016-09-07" version="1">MKMKKVTAMGMAVLMAATMIPAVPAMADDAGKVYYLNFKPEQDEDWQNLAKEYTEETGTEVTVVTAASGQYETTLQSEMAKSDAPTLFQVNGPVGLKNWKDYCYDLKDSDIYSQLTSDSYSLKDGDAVDGIAYVIESYGLIVNKTLLEKAGYTLDDIKSFDDLKKVADDIQSKKDDLGIKGAFTSAGMDGSSDWRFKTHLANLPIYYEYKEDGIDDTDAIKGTYLDNYKNVFDLYITDSTCDGSELSAKTADDSRNEFVNGEAVFYQNGSWEYSELSKTFKDDELAMIPIYFGVDDANEGLATGTENYWCVNKNASEADVKATLDFMNWCVTSEAGTKSMAEDMGFTIPFKTAEAPSNVFVKQDAEYTEAGLTPVSWNFTTMPSEEWKNTLGSALTAYAAGSGSWDDVKSAFVDNWATEKALSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F302</accession>
    <name>A0A174F302_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter permease subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Inner membrane ABC transporter permease protein ycjO</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">L-arabinose transport system permease protein AraP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ycjO_9</name>
        <name evidence="10" type="synonym">araP_3</name>
        <name evidence="10" type="ORF">BWLFYP14_01051</name>
        <name evidence="7" type="ORF">ERS852478_02795</name>
        <name evidence="9" type="ORF">GT712_15310</name>
        <name evidence="8" type="ORF">GT728_08440</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 13 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 14">BIOML-A1</strain>
            <strain evidence="9 13">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000016">
        <property type="protein sequence ID" value="MZL33222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000036">
        <property type="protein sequence ID" value="MZS90400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705245.1">
        <property type="nucleotide sequence ID" value="NZ_JADPFJ010000035.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43186">
        <property type="protein sequence ID" value="CUO43186"/>
        <property type="gene ID" value="ERS852478_02795"/>
    </dbReference>
    <dbReference type="GeneID" id="66494816"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="69"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO43186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL33222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS90400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX63690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="294" mass="32956" checksum="E9EFA017F0208857" modified="2016-09-07" version="1">MQKAFGKKSVIFLFIFPAFLIYTAFVIVSIVWAGYYSFFDWSGVGEKVFVGFKNYIELLTQDDVFRSTVWHTLIYTVINVAIQVFGGLLFAILLSRIKKGRVALQTLYYIPVVISSVAICQIFTKLLSVTPTGIVNQVLSFIDPSLKLMEWISNPQISLYVTAFVEAYKYLGLYMVIFYAALIGVPDELGEAALIDGASTWQEYLYVRIPYIKPVIIANCLLVLNGSLRSFEFSYLLTHGGPGNASELMTTYMYKQAFSSMKYGYGSSVAIMIVIICMVVGMLFRKFTGGGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F4M3</accession>
    <name>A0A174F4M3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Penicillin-binding protein 1A</fullName>
            <ecNumber evidence="8">2.4.1.129</ecNumber>
            <ecNumber evidence="7">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">mrcA</name>
        <name evidence="21" type="ORF">ERS852478_02838</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the transpeptidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="8"/>
    <dbReference type="EC" id="3.4.16.4" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO44621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200955.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000021.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO44621">
        <property type="protein sequence ID" value="CUO44621"/>
        <property type="gene ID" value="ERS852478_02838"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Transgly" evidence="20">
        <location>
            <begin position="84"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="19">
        <location>
            <begin position="447"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="791"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="797"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CUO44621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="863" mass="95616" checksum="D38CECC20B16571F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FAG1</accession>
    <name>A0A174FAG1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Elongation factor G</fullName>
            <shortName evidence="7">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fusA_3</name>
        <name evidence="7" type="synonym">fusA</name>
        <name evidence="10" type="ORF">BWLFYP14_03391</name>
        <name evidence="9" type="ORF">ERS852478_02924</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000022">
        <property type="protein sequence ID" value="CUO47124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO47124">
        <property type="protein sequence ID" value="CUO47124"/>
        <property type="gene ID" value="ERS852478_02924"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="11"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO47124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX67114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="706" mass="78319" checksum="9B5F851C13C9A3CF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FAR7</accession>
    <name>A0A174FAR7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NTE family protein rssA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rssA</name>
        <name evidence="4" type="ORF">ERS852478_02880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45749">
        <property type="protein sequence ID" value="CUO45749"/>
        <property type="gene ID" value="ERS852478_02880"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07208">
        <property type="entry name" value="Pat_hypo_Ecoli_yjju_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037483">
        <property type="entry name" value="YjjU-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="11"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO45749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="288" mass="33157" checksum="6538BC5574666AC8" modified="2016-09-07" version="1">MEDNKKKGLGMVLEGGGMRGLYTAGVLDELMEQGIYADSTVGVSAGAIFGCNYKSRQIGRTLRYNTRFCKDKRYMGLKSWITTGDLYSKDFAYGEVPWKLDVFDTETFARSPMKFTVVCTDIETGKPCYQECRMGDRLDVEWMRASASLPLAARPVNLNGRMYLDGGISDPIPVNWMLSQGYEKNVVVCTRHPGYRKEHNKLMPLLRLKFREYPELVKLLDERHIQYNRMLDKIAYLEKEGRIHVIRPDRDISAKPVERDPAHLKEIYEVGRRVMKADMEKLKAYLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FAW0</accession>
    <name>A0A174FAW0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter substrate-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Uncharacterized ABC transporter solute-binding protein yclQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yclQ</name>
        <name evidence="4" type="ORF">ERS852478_02869</name>
        <name evidence="5" type="ORF">GT728_17240</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000021">
        <property type="protein sequence ID" value="CUO45470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000057">
        <property type="protein sequence ID" value="MZL34886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993459.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000057.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO45470">
        <property type="protein sequence ID" value="CUO45470"/>
        <property type="gene ID" value="ERS852478_02869"/>
    </dbReference>
    <dbReference type="GeneID" id="66494599"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252972" evidence="2">
        <location>
            <begin position="30"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="101"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO45470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL34886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="374" mass="40591" checksum="0514D56AF13995F3" modified="2016-09-07" version="1">MKNRYLSTRIMAIMMAAAMAVSAAPAAFAAERADSETIKEDNQPAADADSDTQEDADAQDSADADKTADAEGTKTEYPLTITTYDYDGNEIETTYEKAPEKVLAVYQGSIETMLALGLEDRLVATAGLDNEVPDELKDAFSKTNYLDEFTPSLETVTMLEPDMILSWSSLFSDKNLGNVTDWIDKGCNTYYNTNTRPDGDRTLENEFTDILNLGKIFDVQDKAQAIVDDAKAVIDKTLTATADVEEKPSVMVLEPLGEDITNYGAKSLGGDMVTQLGATLANPDASTAGKEDIIAANPDVIFVVYMPYAGDDPETVKESQLAVIKDDEALQSLDAVKNGRVYPIMLSEMYASATRTQDGIETFAKGLYPDVNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FKZ0</accession>
    <name>A0A174FKZ0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Autolysin</fullName>
            <ecNumber evidence="5">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lytA_2</name>
        <name evidence="6" type="synonym">lytA</name>
        <name evidence="6" type="ORF">BWLFYP14_03534</name>
        <name evidence="5" type="ORF">ERS852478_03019</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.28" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000024">
        <property type="protein sequence ID" value="CUO50381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000083">
        <property type="protein sequence ID" value="VUX67259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO50381">
        <property type="protein sequence ID" value="CUO50381"/>
        <property type="gene ID" value="ERS852478_03019"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018337">
        <property type="entry name" value="Cell_wall/Cho-bd_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19127">
        <property type="entry name" value="Choline_bind_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51170">
        <property type="entry name" value="CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252788" evidence="3">
        <location>
            <begin position="37"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="Cell wall-binding" evidence="2">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="NAGPA" evidence="4">
        <location>
            <begin position="273"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO50381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX67259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="445" mass="50057" checksum="51AE8BEE2586F086" modified="2016-09-07" version="1">MKDMKRKLPFRKVAVFLILALFLTAGISMRAVTVNAATYVKQDRTSVSITSKKTGWQKINGDYYFYNSKGRLICGSFKYKGYYYYSIANGKRFTGWMKRSGNKYYYNRKNGAMFRNRWATGDKYTYYFNKSGVAIARQWLTQDGKKYYFLSNSTMAKGWQKIGKYYYYFSKKTGVMAKNTWIGKYYVNSKGQRVKSSDTKPTNTKPTVTQSGNTYEYKSSTLNIKLKRKSVHGISYWVAHIKTSNAKQLKSALSNGTYGGSRQTTSDAVSSNGGIIGVNGSAFDYGTGKPSPLGMCIKNGIIYGDYMTSYSVMAVKKDGTIYTPAQGLMGKNLLAAGVKDTYNFGPVLIKDGEAQLPWAETEKYYPRTAVGMVKPNDYVLLVTDTGSYNGLNHWDMVNIFKSYGCTYAYNLDGGGSATLYFNGKVMNKLIGNTQRPCADFLYFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FSD0</accession>
    <name>A0A174FSD0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional xylanase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO51746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060424.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPM010000025.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO51746">
        <property type="protein sequence ID" value="CUO51746"/>
        <property type="gene ID" value="ERS852478_03054"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="162"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO51746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="450" mass="48831" checksum="79FA07510B44290F" modified="2016-09-07" version="1">MDKRVLRERMRRKKRQMMIRHYTKIGLCVIGMILAVVFVVRGIIIPIAHHVAGGGSSDQTVQAQADTEEVQANSDAAVRQPLKGKSDTDKIAAMTAGWHEDANGKWYQNTDGTYFSNGFQDIDGVTYSFDENGYIQTGWVEKGVKDYYFNEDGSYDPSKVRPMLALTFDDGPGEYTDELLDCLEQNNAHATFFMLGQNVSSYPDAPKRMLELGCEIGSHSWDHTQLTTIDLDAVAKQFSDTDDALIQACGQAASVARAPYGDGNSDIYNTVNKPFFMWSLDTEDWKLLDADADYSAVMNGDLTDGTIILMHDIHEPSVKAALRLIPDLIAQGYKLVTVSEMAEAKNVTLQNACYVDFWPSTLSNGDVPGYQGGSDAAASADGTDGTSDASADSSDGSTDSSDGSEDYSDGSSDDGSYDDGSSDDGSYDDGSSDDSEDYSDDSVDYGDGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FTQ5</accession>
    <name>A0A174FTQ5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">phoP_4</name>
        <name evidence="9" type="ORF">ERS852478_03087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO52867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201134.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52867">
        <property type="protein sequence ID" value="CUO52867"/>
        <property type="gene ID" value="ERS852478_03087"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO52867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="224" mass="25872" checksum="A019A9D11D286071" modified="2016-09-07" version="1">MAQSILIVDDEKEIVSMLYCYFSKLGYTVYTATAGNAALKEVEKKPDIILLDVNMPDIDGFTVCERIRDYVSCPIIFLTARIEDSDKIKGFSIGADDYVIKPFSVDELEARIAAHLRREKRHNTCSKVQFDEDMVIDYSSRIVFYHNKDMAFTKKEFDIISFLSQNKGIVFDRETIYEKVWGLDGIGDNTVVTEHIRRIRAKFLSLGDRPYIETVWGCGYKWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FUX1</accession>
    <name>A0A174FUX1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000025">
        <property type="protein sequence ID" value="CUO52340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO52340">
        <property type="protein sequence ID" value="CUO52340"/>
        <property type="gene ID" value="ERS852478_03077"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO52340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="117" mass="13369" checksum="40908E1F5A1D0738" modified="2016-09-07" version="1">MEEFSGATATSIIQEFYINMPLSNLVSLIKNNADEEIDITSKSSNKYRYQANRAFIIGRIKIIFPKILCGLSELSVIEKLYKEAVRCRSQILPGRSFPRKKLKSKGRSHFRNKKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GC70</accession>
    <name>A0A174GC70_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase CwlH</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cwlH</name>
        <name evidence="2" type="ORF">ERS852478_03246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO58005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380853.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO58005">
        <property type="protein sequence ID" value="CUO58005"/>
        <property type="gene ID" value="ERS852478_03246"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C51" evidence="1">
        <location>
            <begin position="19"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO58005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="306" mass="31836" checksum="772D70D4E25A339B" modified="2016-09-07" version="1">MATASTIIKTASNEIGVKETGNNNVKYNTEYYGKAVNGDAYPWCAVFVWWVFKHSGASSIFYGGGKTASVYEIWRYYNSLGRVYSSPKVGDLAIITTSAGGTYGHVGIVKSVSGNTYVTIDGNSKDQVRTTNRTVGSPKASFCRPAYGSGSGSSTNLSMGSSGTDVKDMQKKLIALGYSCGSSGADGSFGQGTYNAVCNFQRDHGLTVDGVIGPTTRSKINSAYSNLGGSSSGTNLSMGSSGTDVKNMQKKLIALGYSCGSSGADGIFGQGTYNAVCKFQKANGLSVDGIIGPATRAKINALYAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GD02</accession>
    <name>A0A174GD02_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spore coat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_03277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Spore coat</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CotF family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000030">
        <property type="protein sequence ID" value="CUO59018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705107.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59018">
        <property type="protein sequence ID" value="CUO59018"/>
        <property type="gene ID" value="ERS852478_03277"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012851">
        <property type="entry name" value="Spore_coat_CotF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07875">
        <property type="entry name" value="Coat_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="3">
        <location>
            <begin position="9"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO59018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="152" mass="17369" checksum="7ECC75CD1F977214" modified="2016-09-07" version="1">MILKEKERSVIEDLQTQEKSCVEKYGKYAEQARDPELKNLFRNIQQEEQKHYESLSMILSGSVPECNCNDRSGRDYQPKAVYAAMSSPEDKQHDAFLATDCIGTEKLVSGTYNDDVFAFGDSGVRKLLADIQIEEQNHAEMLYKYKTVNGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GG42</accession>
    <name>A0A174GG42_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase, IS605 OrfB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_03298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transposase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO59849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59849">
        <property type="protein sequence ID" value="CUO59849"/>
        <property type="gene ID" value="ERS852478_03298"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01766">
        <property type="entry name" value="tspaseT_teng_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="5">
        <location>
            <begin position="179"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="6">
        <location>
            <begin position="320"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO59849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="418" mass="49225" checksum="F8E00DB4509E961A" modified="2016-09-07" version="1">MLLSKKTSIKVSREYANLIGHMCYAASKLWNVCNYERQHYKETGIEQHPDWYYQKKAHKEDLWYKQLPSQTAQEVCKLLDKAWKSFYALKRSGGIETPRPPRFKQESIPITYMQMGIVHERDTDRVRLSLPKTLKKYMEETYQIHENFLYLENKIFRGMDQIKQLRIYPPEKGNCKIIVVYEVSGQEELPQNGHELSIDLGLHNLMTCYDSGNGKTFILGRKYLALERYFHKEIARVQAQWYGQQSGKGVKYLATSKHIRKLYKRKHDSVTDYLHKVTRYLAEYCREQGITCVVAGDIRNIRREKDLGHRTNQKFHSLPYNRIYIMLEYKLKRYGIRFIKQEESYTSQCSPLSPKVGKRYAEPSKRKERGLYRDGNRTYNADAVGAYNILRKYHSVSGVKKELSVTGLKTPEIIKVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GIK8</accession>
    <name>A0A174GIK8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO62414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201342.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO62414">
        <property type="protein sequence ID" value="CUO62414"/>
        <property type="gene ID" value="ERS852478_03378"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008022557" evidence="1">
        <location>
            <begin position="28"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO62414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="198" mass="22757" checksum="25CD26C724DBD4B1" modified="2016-09-07" version="1">MKKKSIKVITVLLAMVMLFVSSSSVSAMSLQNTIAHRALKQQIIADKRQYCNFGMTTIKYVYADIDGDHVAELITEPGYGYLTQAIYDYQNGNVRRVATVGQGDFTKYYPKHKVIYIKNSGHMGVLCDYYYKYVKGTYKMAARAQKDYGNRSYDEKPVKITYTVNDKKVTKAEYSAYVKKLTKGEKGKSFSKLKWKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GJM1</accession>
    <name>A0A174GJM1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000032">
        <property type="protein sequence ID" value="CUO61368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201290.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO61368">
        <property type="protein sequence ID" value="CUO61368"/>
        <property type="gene ID" value="ERS852478_03339"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023387">
        <property type="entry name" value="DUF1653-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037135">
        <property type="entry name" value="DUF1653-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07866">
        <property type="entry name" value="DUF1653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1653" evidence="2">
        <location>
            <begin position="83"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO61368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="160" mass="18668" checksum="44BA45A450919FF2" modified="2016-09-07" version="1">MTKIRIIKKNNDCSMEYEVGDICEVTGTWYGGVHINGRSGIPVSLDKEEYMELNTEPELEESDSAENENISETPEHDIHAGDIVQHFKREWVSPDTSEYLYKVLAVAHHTENGEKLMIYQALYAPFKICARPYDMFMSEVDRDKYPDIKQKYRFEKYTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GLL4</accession>
    <name>A0A174GLL4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cardiolipin synthase</fullName>
            <ecNumber evidence="14">2.7.8.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cls_5</name>
        <name evidence="14" type="ORF">ERS852478_03408</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.8.-" evidence="14"/>
    <dbReference type="EMBL" id="CYZN01000033">
        <property type="protein sequence ID" value="CUO63434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO63434">
        <property type="protein sequence ID" value="CUO63434"/>
        <property type="gene ID" value="ERS852478_03408"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022924">
        <property type="entry name" value="Cardiolipin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04265">
        <property type="entry name" value="bac_cardiolipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUO63434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="532" mass="62419" checksum="286CFABFC52F5DF6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GS84</accession>
    <name>A0A174GS84_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FMN-dependent NADH-azoreductase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">azoR</name>
        <name evidence="3" type="ORF">BWLFYP14_02264</name>
        <name evidence="2" type="ORF">ERS852478_03430</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000042">
        <property type="protein sequence ID" value="VUX65899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64127">
        <property type="protein sequence ID" value="CUO64127"/>
        <property type="gene ID" value="ERS852478_03430"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="7"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO64127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="133" mass="14993" checksum="1ED1856313525043" modified="2016-09-07" version="1">MRNGGTCVLKDDMAEILGMFRKADVLVLATPVYFYGISAQMKTFIDRTYPIWQHLGKKEVYYIISAGLGEDIIERPLGDLDGFVEHLEEYKIAGKIYAANVMDAGLVRNQSVFKKAYDMGYSVQNAEKLRVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZU7</accession>
    <name>A0A174GZU7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055060674.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000036.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66566">
        <property type="protein sequence ID" value="CUO66566"/>
        <property type="gene ID" value="ERS852478_03506"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="8"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO66566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="1028" mass="119140" checksum="64121A73C0DDAD66" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GZV0</accession>
    <name>A0A174GZV0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_03470</name>
        <name evidence="1" type="ORF">ERS852478_03498</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000036">
        <property type="protein sequence ID" value="CUO66339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000081">
        <property type="protein sequence ID" value="VUX67195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO66339">
        <property type="protein sequence ID" value="CUO66339"/>
        <property type="gene ID" value="ERS852478_03498"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025359">
        <property type="entry name" value="DUF4263"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14082">
        <property type="entry name" value="DUF4263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO66339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX67195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="326" mass="37800" checksum="12BDC672A0DCB75F" modified="2016-09-07" version="1">MFCFVEQLCIPDCGEVAKKAEAEAVFKELLASCTSRLARTTLGVRPHEEALFDIIRGSIMNLYKRDYIKSVPTKQEMQLYEGILCTERKAVGDRGFGKINHRRLYPAAVRHYDSLFPNNHIELFDFQNEGNMEQLNEEFCALIHDANTNERNVLRFINHRPAYHIIAGVFKYYNFGHHDAYVFPEFALGKYIADYLLIGKSSGGYEFVFVELEHPNGRTTLKSGHEGETFRKGTYQIYDWKAEIEAHFSASFVTITKYSNKSSLPKEFSEYDSSRFHYAVVAGLREDYNEATYRDRRNKVTQQNILTLHYDNLYDKACELETAQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H1T3</accession>
    <name>A0A174H1T3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Abortive infection bacteriophage resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000037">
        <property type="protein sequence ID" value="CUO67276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201417.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO67276">
        <property type="protein sequence ID" value="CUO67276"/>
        <property type="gene ID" value="ERS852478_03531"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017034">
        <property type="entry name" value="Abi_system_AbiD/AbiF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011664">
        <property type="entry name" value="Abi_system_AbiD/AbiF-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07751">
        <property type="entry name" value="Abi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034934">
        <property type="entry name" value="AbiF_AbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO67276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="313" mass="37217" checksum="87A4B5E32027D011" modified="2016-09-07" version="1">MQTPKKFSSFSDQVSWISDEKGIKIKDREYAEEMLRQIGYFPLMGGYKHLFRISNTKKYKAGTSFEEIVSLYKFDAELRELFFKYLLQIERQMRSLMSYYFTEMYGAEQKQYLDANNYNNTKRNHATIVKLIATLKRVTTTTDYTYINYYRKTYGEIPLWVLANVLTFGNLSKMFRVFPQSLKSKVSKNFEPLNQHQMEQFLSVLTKYRNVCAHGERLFTYRTVDAIADTPLHKKLSLPQSGNQYEKGKQDLFAVVIAFRYLLPGKDFLEFKRKLIKEIDRVNREVEHISEVELLNKMGFPKNWKNITRYHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H8C7</accession>
    <name>A0A174H8C7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379849.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71212">
        <property type="protein sequence ID" value="CUO71212"/>
        <property type="gene ID" value="ERS852478_03659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO71212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="61" mass="7140" checksum="EFF6CBD6266BC010" modified="2016-09-07" version="1">MNEKFLKVEDIMGILGISKSVAYKLMRELNDEMVKKGYIAIRGRVNRKYFEERFYGMSDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H8H7</accession>
    <name>A0A174H8H7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sensory transduction protein regX3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">regX3_6</name>
        <name evidence="6" type="ORF">ERS852478_03592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69145">
        <property type="protein sequence ID" value="CUO69145"/>
        <property type="gene ID" value="ERS852478_03592"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="53"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="53"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO69145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="156" mass="18234" checksum="1A294C5A60D3F7EA" modified="2016-09-07" version="1">MDIEESGKQIGEKLFLLLNEEQKNALMQYILEQGACHGTVFNSCHTSFAAKKNPLTEIQEGELYLCLEHRTVRVRERMINLTSKEFDILALLIANPKRVFTYELITDLVWKEDCDFYSRKAIHNHISKLRKKLRFEPDLPNYIESVAGIGYKFEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HCB1</accession>
    <name>A0A174HCB1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO71941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008393102.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71941">
        <property type="protein sequence ID" value="CUO71941"/>
        <property type="gene ID" value="ERS852478_03684"/>
    </dbReference>
    <dbReference type="GeneID" id="15230413"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO71941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="76" mass="8403" checksum="507ECB3CAC7663F5" modified="2016-09-07" version="1">MIGLKKRDIKKALKAGAKAGGVSLADVRADIEATIDEAMNSTDPEVQANFKKYFGKKRPTPEEYIYTITKKTTVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HGD8</accession>
    <name>A0A174HGD8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">DNA replication protein dnaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dnaC_3</name>
        <name evidence="2" type="ORF">ERS852478_03699</name>
        <name evidence="3" type="ORF">GT728_18735</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000043">
        <property type="protein sequence ID" value="CUO72190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000074">
        <property type="protein sequence ID" value="MZL35155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703775.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000074.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72190">
        <property type="protein sequence ID" value="CUO72190"/>
        <property type="gene ID" value="ERS852478_03699"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="110"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO72190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL35155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="271" mass="31349" checksum="AC462203FD000750" modified="2016-09-07" version="1">MREEDTVCVGSDGLKYCKVCGEAKEAFFPKGGFMGMKKHSRQCACDRKVYEEEQKYFKDKEHRELVSRNTSICFDESRMEEWTFENADMSDTVMHRAKKYVDNWEEMKRNHIGCLFWGPVGTGKSFIAGCIANELLKQEVMVKMTNFNTIIDDIFPLADKTEYINALASYQLLIIDDLGVERNSEYALGIIFSVIDRRIRSGRPLIITTNLPLKEIKNETMLDKRRIYDRILEMCTPMYVGGTSKREVIASMKMEKAKTLLNTNRGEEDCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HHN9</accession>
    <name>A0A174HHN9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bifunctional fucokinase/L-fucose-1-P-guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_03712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000044">
        <property type="protein sequence ID" value="CUO72630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201502.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000044.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO72630">
        <property type="protein sequence ID" value="CUO72630"/>
        <property type="gene ID" value="ERS852478_03712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012887">
        <property type="entry name" value="Fucokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07959">
        <property type="entry name" value="Fucokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Fucokinase" evidence="6">
        <location>
            <begin position="106"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="747"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO72630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="981" mass="109945" checksum="88CB47C6D809B844" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HQN7</accession>
    <name>A0A174HQN7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000051">
        <property type="protein sequence ID" value="CUO75390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201534.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000051.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75390">
        <property type="protein sequence ID" value="CUO75390"/>
        <property type="gene ID" value="ERS852478_03803"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008023656" evidence="1">
        <location>
            <begin position="35"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO75390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="149" mass="15949" checksum="6F982E90917E561C" modified="2016-09-07" version="1">MTKIKNTKKGMAKKTLSMSLVVAMLATSNVPVWAAEFSDGSDVAVTSDAEASVAETFSDDVTETPVVEDTTDNTAVATAAEVSSDSFSVTPEFTDNANNAIKDNAVTWGTTVKAKFKVTAKDNKAIDSNIKFHTLQKHLFSLIFHAKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KCS5</accession>
    <name>A0A174KCS5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">xseB</name>
        <name evidence="4" type="ORF">ERS852478_01164</name>
        <name evidence="5" type="ORF">ERS852523_00485</name>
        <name evidence="6" type="ORF">GT728_00370</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">2789STDY5834863</strain>
            <strain evidence="5 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP07927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055149396.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2138"/>
    <dbReference type="EnsemblBacteria" id="CUN82374">
        <property type="protein sequence ID" value="CUN82374"/>
        <property type="gene ID" value="ERS852478_01164"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP07927">
        <property type="protein sequence ID" value="CUP07927"/>
        <property type="gene ID" value="ERS852523_00485"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1722">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN82374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP07927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZL31687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="79" mass="9278" checksum="1EEB0ACCA200002B" modified="2016-09-07" version="1">MVKKENCEQLQEEKPLEEMFAELDLLAEKLENRDTSLEDSFILYRQGMELLKLCSGKLDTVEKKMLQLNEDGTFSEFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KHQ9</accession>
    <name>A0A174KHQ9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Arginine transport ATP-binding protein ArtM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">artM_2</name>
        <name evidence="5" type="synonym">artM_1</name>
        <name evidence="8" type="ORF">BWLFYP14_01775</name>
        <name evidence="5" type="ORF">ERS852478_00746</name>
        <name evidence="6" type="ORF">ERS852523_00597</name>
        <name evidence="7" type="ORF">GT728_03900</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 9">2789STDY5834863</strain>
            <strain evidence="6 10">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="7 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="8 11" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP11634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX64976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706482.1">
        <property type="nucleotide sequence ID" value="NZ_WWVL01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000016_gene3689"/>
    <dbReference type="EnsemblBacteria" id="CUN66636">
        <property type="protein sequence ID" value="CUN66636"/>
        <property type="gene ID" value="ERS852478_00746"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11634">
        <property type="protein sequence ID" value="CUP11634"/>
        <property type="gene ID" value="ERS852523_00597"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN66636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUP11634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MZL32360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="VUX64976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="246" mass="27187" checksum="2725F2FEE1C6BFCE" modified="2016-09-07" version="1">MSDKNVLIQVKDLKKAFGTNQVLDGITTDICQGEVVAVIGPSGSGKSTFLRSLNLLEVPTGGQILFEGTDITDPKVDINRHRQKIGMVFQQFNLFPHKTVKQNIMLAPVELKLMTKDEASKKADELLARVGLPDKANAYPDMLSGGQKQRIAIARSLAMNPDVMLFDEPTSALDPEMVGEVLELMKELAQSGMTMVVVTHEMGFAREVATRVLFIDDGKIQEENTPKEFFANPKNPRLKDFLSKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174LVA6</accession>
    <name>A0A174LVA6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01473</name>
        <name evidence="2" type="ORF">ERS852523_01053</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP25918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055150077.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95223">
        <property type="protein sequence ID" value="CUN95223"/>
        <property type="gene ID" value="ERS852478_01473"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP25918">
        <property type="protein sequence ID" value="CUP25918"/>
        <property type="gene ID" value="ERS852523_01053"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN95223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP25918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="146" mass="17545" checksum="9297F73DB45253A3" modified="2016-09-07" version="1">MIKRVKLETIYKMAKEDNEKIKERKLFPDGWDEKVYDYYNKLSKESSDVEMFMEFLGGEDSPLEMAYAYRRNMYIMLYTMNATDTIAFVDGEYDIFYIVSKDGDDYNSWEWCFTNNIDPIKYRGDDGDEPVPEWLIKKYEEKIGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174M8J5</accession>
    <name>A0A174M8J5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murT</name>
        <name evidence="7" type="ORF">BWLFYP14_00285</name>
        <name evidence="4" type="ORF">ERS852478_01687</name>
        <name evidence="5" type="ORF">ERS852523_01265</name>
        <name evidence="6" type="ORF">GT712_08835</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">2789STDY5834863</strain>
            <strain evidence="5 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:59488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with GatD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurT subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP32764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707292.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000007.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2953"/>
    <dbReference type="EnsemblBacteria" id="CUO03649">
        <property type="protein sequence ID" value="CUO03649"/>
        <property type="gene ID" value="ERS852478_01687"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP32764">
        <property type="protein sequence ID" value="CUP32764"/>
        <property type="gene ID" value="ERS852523_01265"/>
    </dbReference>
    <dbReference type="GeneID" id="66496151"/>
    <dbReference type="eggNOG" id="COG0771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02214">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043703">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013564">
        <property type="entry name" value="MurT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08353">
        <property type="entry name" value="MurT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="58"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="MurT_C" evidence="3">
        <location>
            <begin position="323"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO03649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUP32764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS89172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX67444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="444" mass="49586" checksum="BFB2BA183C2A4A60" modified="2016-09-07" version="1">MKIRVMIAVCAAKFVGYVCKKMGRQGVTWAGKVAIKICPDILEQLSSQVRKAIFATCGTNGKTTTNNMLCAALEAEGQKVICNHTGSNMLNGVVAAFVLASKWNGKIDADYACIEADEASTRHIFPRIKPDYMLLTNLFRDQLDRYGEIDITMNILEEMMRKVPKMQIIVNGDDALSAYLAMDSGNPYVTYGISKPVIKSAANEIREGRFCKRCGEKLEYRFYHYSQLGDYYCPKCGFARPKPDFDAEDVKVGDQLSFCVEGKHIVANYKGFYNVYNILAAYAGVRTAGFAGEHFGDMLRRFNPENGRMEQFRIKGTGVTLNLAKNPAGFNQNISAVMQDQAPKDIIIAINDNAQDGTDISWLWDVDFDLLGNDSVKSITVSGIRCQDMRLRLKYVDIPSVLEGDVEKAIRDRVEDGVGNLYVLVNYTALFSTRNILKRLEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MUB3</accession>
    <name>A0A174MUB3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutathione transport system permease protein gsiC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gsiC_2</name>
        <name evidence="7" type="ORF">ERS852478_02954</name>
        <name evidence="8" type="ORF">ERS852523_01497</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">2789STDY5834863</strain>
            <strain evidence="8 10">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO48197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP40054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055150720.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000012.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000028_gene209"/>
    <dbReference type="EnsemblBacteria" id="CUO48197">
        <property type="protein sequence ID" value="CUO48197"/>
        <property type="gene ID" value="ERS852478_02954"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP40054">
        <property type="protein sequence ID" value="CUP40054"/>
        <property type="gene ID" value="ERS852523_01497"/>
    </dbReference>
    <dbReference type="GeneID" id="66493655"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO48197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP40054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="306" mass="33462" checksum="971255336DE962D3" modified="2016-09-07" version="1">MGRYLGKRLASTIPLLLVISFVVFMFIHMIPGDPARLVAGQDATKEDVAVVREQLGLDEPLLVQYGKYMKGLFTGDLGSSIKNGKTVAETIAPRLKPTIMLTFSSMIWAAIIGIAIGIIAAVFHGRILDYVGMIIAIAGISVPSFWLGLELIQLFSVSLGWLPTSGLETWKSYILPSLTMGAGIMAVLARFSRSSMLETMREDYVRTARAKGLSESLVVMRHAFKNSLIEIVTVAGLQIGGLLSGSVMAETVFSIPGLGRLLVDSIQMRDYKVVQALLLFFATEYILINLIVDVLYGVINPRVRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174N7V9</accession>
    <name>A0A174N7V9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC transporter substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00380</name>
        <name evidence="3" type="ORF">ERS852523_01569</name>
        <name evidence="4" type="ORF">GT712_06070</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000013">
        <property type="protein sequence ID" value="CUP42175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000009">
        <property type="protein sequence ID" value="MZS88664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380669.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000069.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000060_gene470"/>
    <dbReference type="EnsemblBacteria" id="CUN52858">
        <property type="protein sequence ID" value="CUN52858"/>
        <property type="gene ID" value="ERS852478_00380"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP42175">
        <property type="protein sequence ID" value="CUP42175"/>
        <property type="gene ID" value="ERS852523_01569"/>
    </dbReference>
    <dbReference type="GeneID" id="66496010"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5014252045" evidence="1">
        <location>
            <begin position="25"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN52858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP42175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="559" mass="63903" checksum="F38126AEB01E4ECB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NYH1</accession>
    <name>A0A174NYH1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_02620</name>
        <name evidence="1" type="ORF">ERS852478_00122</name>
        <name evidence="2" type="ORF">ERS852523_01868</name>
        <name evidence="3" type="ORF">GT728_15985</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
            <strain evidence="2 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP51570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000047">
        <property type="protein sequence ID" value="MZL34653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703158.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000020_gene103"/>
    <dbReference type="EnsemblBacteria" id="CUN44338">
        <property type="protein sequence ID" value="CUN44338"/>
        <property type="gene ID" value="ERS852478_00122"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP51570">
        <property type="protein sequence ID" value="CUP51570"/>
        <property type="gene ID" value="ERS852523_01868"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032T12">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN44338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP51570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="214" mass="24966" checksum="D2FF89FA19784AE1" modified="2016-09-07" version="1">MNDNKMITQSRIIEEYGWTKSLISKFLPDPVLKANPHYRKAAPMRLWDEDTVKQVMTTSEFQDAMEKANKRKKSASKAVETKYSNMNHSVQLFIDSITIKVLSDEELKTKALKAKQEWYQCHPCSLNGDWIDEPYMKNAYTANEETINRWIVNYIRHNLVSYDNFLGSIDGKVGSVEAYPEVKIAVLEKIANTYPKYKDECERQIFFVDFNADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174Q8K2</accession>
    <name>A0A174Q8K2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative sporulation protein YyaC</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Spore protease YyaC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yyaC</name>
        <name evidence="5" type="ORF">BWLFYP14_01230</name>
        <name evidence="1" type="ORF">ERS852478_00845</name>
        <name evidence="2" type="ORF">ERS852523_02500</name>
        <name evidence="4" type="ORF">GT712_07925</name>
        <name evidence="3" type="ORF">GT728_00970</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN71069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000026">
        <property type="protein sequence ID" value="CUP69652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000002">
        <property type="protein sequence ID" value="MZL31804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000013">
        <property type="protein sequence ID" value="MZS88998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706911.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000002.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000122_gene2856"/>
    <dbReference type="EnsemblBacteria" id="CUN71069">
        <property type="protein sequence ID" value="CUN71069"/>
        <property type="gene ID" value="ERS852478_00845"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP69652">
        <property type="protein sequence ID" value="CUP69652"/>
        <property type="gene ID" value="ERS852523_02500"/>
    </dbReference>
    <dbReference type="GeneID" id="66492973"/>
    <dbReference type="eggNOG" id="ENOG50313RY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009665">
        <property type="entry name" value="DUF1256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06866">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02841">
        <property type="entry name" value="spore_YyaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN71069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP69652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL31804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS88998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX64095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="184" mass="19955" checksum="2D256A6B4B05E359" modified="2016-09-07" version="1">MVFYVDSQKSSSAEEIAFLLNKCILQYPGRWSELVFLCIGSDRVTGDCLGPYIGHQLLEHLNTDTHGVYVYGTLKSPVHALNLSRISRQIKILHPEGLVIAVDASLGQKKHLGYVTIADGALYPGAAVQKELPPVGDIHITGIVNIAGVLEQLTLQTTRLSTVISLADTITQGIVNYTNSLICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QTE1</accession>
    <name>A0A174QTE1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 8" type="primary">grpE</name>
        <name evidence="10" type="ORF">BWLFYP14_00342</name>
        <name evidence="7" type="ORF">ERS852478_01062</name>
        <name evidence="8" type="ORF">ERS852523_02677</name>
        <name evidence="9" type="ORF">GT728_14305</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
            <strain evidence="8 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000030">
        <property type="protein sequence ID" value="CUP75036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000037">
        <property type="protein sequence ID" value="MZL34339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381213.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000030.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000035_gene3846"/>
    <dbReference type="EnsemblBacteria" id="CUN78787">
        <property type="protein sequence ID" value="CUN78787"/>
        <property type="gene ID" value="ERS852478_01062"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP75036">
        <property type="protein sequence ID" value="CUP75036"/>
        <property type="gene ID" value="ERS852523_02677"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 10" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN78787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP75036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL34339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX67497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="214" mass="24490" checksum="433DB391FB0B0CB4" modified="2016-09-07" version="1">MSEETKNTAQEEETTDTPVTEETVENEPEVVENGEAETEEIPVEDGDEEASQDDKKDSKSKTSFFGKKKKEKDKFEQQIEELTDRLKRNMAEFDNFRKRTEKEKSSMYIIGAKDIVEKMLPVVDNFERGLAQAPEGDSFADGMKMIYKQLITTLDELGVKPIEAVGKEFDPNFHNAVMHVEDEEAGENIVVEEFQKGYTYKDFVVRHSMVKVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174RN80</accession>
    <name>A0A174RN80_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NAD(P)H-dependent oxidoreductase subunit E</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">NADH-quinone oxidoreductase subunit E</fullName>
            <ecNumber evidence="8">1.6.5.11</ecNumber>
            <ecNumber evidence="11">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nuoE_2</name>
        <name evidence="11" type="synonym">nuoE</name>
        <name evidence="11" type="ORF">BWLFYP14_03284</name>
        <name evidence="7" type="ORF">ERS852478_00572</name>
        <name evidence="8" type="ORF">ERS852523_03046</name>
        <name evidence="10" type="ORF">GT712_13235</name>
        <name evidence="9" type="ORF">GT728_05160</name>
    </gene>
    <organism evidence="8 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 12">2789STDY5834863</strain>
            <strain evidence="8 13">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 15 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 16">BIOML-A1</strain>
            <strain evidence="10 15">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="11 14" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.11" evidence="8"/>
    <dbReference type="EC" id="1.6.99.5" evidence="11"/>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN59657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000038">
        <property type="protein sequence ID" value="CUP85586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000009">
        <property type="protein sequence ID" value="MZL32608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000027">
        <property type="protein sequence ID" value="MZS90010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000076">
        <property type="protein sequence ID" value="VUX67007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706192.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000024_gene315"/>
    <dbReference type="EnsemblBacteria" id="CUN59657">
        <property type="protein sequence ID" value="CUN59657"/>
        <property type="gene ID" value="ERS852478_00572"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP85586">
        <property type="protein sequence ID" value="CUP85586"/>
        <property type="gene ID" value="ERS852523_03046"/>
    </dbReference>
    <dbReference type="GeneID" id="66493118"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN59657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP85586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL32608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MZS90010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="VUX67007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="160" mass="17934" checksum="A0EE14F370D04005" modified="2016-09-07" version="1">MLDQSFYQKADEIIAFYGKKPASLIPIMQDIQGVYRYLPEELLTYVAEQIGVTEAKAFSVATFYENFSFDAKGKYVIKVCDGTACHVRKSIPVLEELYKKLGLSKTKKTTDDMMFTVETVSCLGACGLAPTMMVNEEVYPRMTPEKADELIDKLRGGEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174RP32</accession>
    <name>A0A174RP32_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00833</name>
        <name evidence="3" type="ORF">ERS852523_03032</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000037">
        <property type="protein sequence ID" value="CUP85038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059015.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000099.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000175_gene3962"/>
    <dbReference type="EnsemblBacteria" id="CUN69672">
        <property type="protein sequence ID" value="CUN69672"/>
        <property type="gene ID" value="ERS852478_00833"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP85038">
        <property type="protein sequence ID" value="CUP85038"/>
        <property type="gene ID" value="ERS852523_03032"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032Y6A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043739">
        <property type="entry name" value="DUF5684"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18936">
        <property type="entry name" value="DUF5684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN69672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP85038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="149" mass="16664" checksum="2CB2B8C9020C0DE9" modified="2016-09-07" version="1">MGLIAISSMVFLGGMYLMIAFAWWLLQIIANWRIFTKAGEAGWKSIIPIYGDYISYKIAWQPAYFWLTLVLGIVSSCLQGTLETNDSLMISMIIVLIKIILAIISIMYSVKLARAFGRGTGFAIGLIFLPPIFMLILGFGDDRYYGADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SP71</accession>
    <name>A0A174SP71_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 12" type="primary">clpP</name>
        <name evidence="15" type="ORF">BWLFYP14_00874</name>
        <name evidence="11" type="ORF">ERS852478_03172</name>
        <name evidence="12" type="ORF">ERS852523_03509</name>
        <name evidence="14" type="ORF">GT712_16135</name>
        <name evidence="13" type="ORF">GT728_16490</name>
    </gene>
    <organism evidence="12 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 16">2789STDY5834863</strain>
            <strain evidence="12 17">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="13 19 20" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 20">BIOML-A1</strain>
            <strain evidence="14 19">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="15 18" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000053">
        <property type="protein sequence ID" value="CUP98466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000051">
        <property type="protein sequence ID" value="MZL34748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000041">
        <property type="protein sequence ID" value="MZS90547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000024">
        <property type="protein sequence ID" value="VUX63396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705991.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000051.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000094_gene758"/>
    <dbReference type="EnsemblBacteria" id="CUO55414">
        <property type="protein sequence ID" value="CUO55414"/>
        <property type="gene ID" value="ERS852478_03172"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP98466">
        <property type="protein sequence ID" value="CUP98466"/>
        <property type="gene ID" value="ERS852523_03509"/>
    </dbReference>
    <dbReference type="GeneID" id="66494504"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO55414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUP98466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL34748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS90547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VUX63396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="193" mass="20928" checksum="45D7F2F097A85B99" modified="2016-09-07" version="1">MSLVPYVIEQTSRGERSYDIYSRLLKDRIIFLGEEVNDVSAGLIVSQLLFLEAEDPGKDIQLYINSPGGSVTAGMAIYDTMQYIKCDVSTICLGMAASMGAFLLAGGAKGKRFALPHSTIMIHQPSGGAQGQATEIQIVADHIAQTKRTLNELLAANTGQPIEVVERDTDRDNYMTAEEAKAYGLIDGVVMHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SW81</accession>
    <name>A0A174SW81_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03160</name>
        <name evidence="3" type="ORF">ERS852523_03523</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000027">
        <property type="protein sequence ID" value="CUO55064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000053">
        <property type="protein sequence ID" value="CUP98799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705968.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000042.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000152_gene3983"/>
    <dbReference type="EnsemblBacteria" id="CUO55064">
        <property type="protein sequence ID" value="CUO55064"/>
        <property type="gene ID" value="ERS852478_03160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP98799">
        <property type="protein sequence ID" value="CUP98799"/>
        <property type="gene ID" value="ERS852523_03523"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045403">
        <property type="entry name" value="HTH_59_Firmicutes_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20038">
        <property type="entry name" value="HTH_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_59" evidence="1">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO55064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP98799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="62" mass="7063" checksum="F96F67B45D8AA159" modified="2016-09-07" version="1">MDYMTLKEAAEKWGVTPRRVNYYCAAGRISGAVKMATIWLIPKDAEKPIDGRTKQGKVKKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WUE5</accession>
    <name>A0A173WUE5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Predicted NADH:ubiquinone oxidoreductase, subunit RnfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_00074</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN42954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199489.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN42954">
        <property type="protein sequence ID" value="CUN42954"/>
        <property type="gene ID" value="ERS852478_00074"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="4">
        <location>
            <begin position="121"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN42954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="198" mass="21239" checksum="F104B66D611A0EAD" modified="2016-09-07" version="1">MNNQNFYLRLIALLLIIMAVFFYNGTVKDKEQTQDIADLTAKVESLENQQDQILTALQETYEEQKTAAESKTSSDASSKADNKSEKDSTDNKENTDQADSEEADDSDNVYKNGTFEGSGTGYGGTITVQVTLEDDTITAVSVVSAPGEDSAYLSQGENVINSIISEQSTDVDTISGATFSSTGILEAVNDALSKAENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WUP1</accession>
    <name>A0A173WUP1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">feoB_1</name>
        <name evidence="14" type="ORF">ERS852478_00063</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CUN42646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199484.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN42646">
        <property type="protein sequence ID" value="CUN42646"/>
        <property type="gene ID" value="ERS852478_00063"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041069">
        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
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            <end position="303"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="409"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="470"/>
        </location>
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            <end position="527"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="678"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="13">
        <location>
            <begin position="2"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN42646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="719" mass="78367" checksum="564B3BBADD1C9850" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173WVC2</accession>
    <name>A0A173WVC2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_00090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN43421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199498.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN43421">
        <property type="protein sequence ID" value="CUN43421"/>
        <property type="gene ID" value="ERS852478_00090"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030GJT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008014944" evidence="2">
        <location>
            <begin position="37"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN43421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="169" mass="17921" checksum="FE2A6349CCE77988" modified="2016-09-07" version="1">MRHIDEIQIAGTAILLCGAMFAVSAVAPTGNTVSKAVTNFTEAPETAAEAQAQAEAQAEEDGFTIYTQESNYDDSDYDNSYNDTSYDDSSYNTDTTQDGSLDDTGQENDNTDTGDGSSDDGSSDQTSSDDTGNDSSDQIDYPSDDNSGDETDGSLDSSDTWEDNGEEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X0C0</accession>
    <name>A0A173X0C0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twitching motility protein PilT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_02617</name>
        <name evidence="1" type="ORF">ERS852478_00119</name>
        <name evidence="2" type="ORF">ERS852523_01871</name>
        <name evidence="4" type="ORF">GT712_00865</name>
        <name evidence="3" type="ORF">GT728_16000</name>
    </gene>
    <organism evidence="1 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 6">2789STDY5834863</strain>
            <strain evidence="2 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 9 10" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 10">BIOML-A1</strain>
            <strain evidence="4 9">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000017">
        <property type="protein sequence ID" value="CUP51661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000047">
        <property type="protein sequence ID" value="MZL34656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703153.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000047.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000020_gene106"/>
    <dbReference type="EnsemblBacteria" id="CUN44257">
        <property type="protein sequence ID" value="CUN44257"/>
        <property type="gene ID" value="ERS852478_00119"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP51661">
        <property type="protein sequence ID" value="CUP51661"/>
        <property type="gene ID" value="ERS852523_01871"/>
    </dbReference>
    <dbReference type="GeneID" id="66495905"/>
    <dbReference type="eggNOG" id="COG0433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN44257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP51661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS87676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX66245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="139" mass="15321" checksum="343538F8994177B2" modified="2016-09-07" version="1">MVELIVGKKGKGKTKVLLDKVNGAVKEANGSIVYLDKSTKHMYELNNKVRLIDVSGFPIKNADEFVGFICGILSQDHDLEQIYLDSFLKVAKLEDKDITGTLGQLDEIGKQFNVTFVISVSLDKEEIPEALHGKISVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X0N6</accession>
    <name>A0A173X0N6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BWLFYP14_02642</name>
        <name evidence="1" type="ORF">ERS852478_00144</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN44870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN44870">
        <property type="protein sequence ID" value="CUN44870"/>
        <property type="gene ID" value="ERS852478_00144"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN44870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="VUX66270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="167" mass="20272" checksum="94D2802F302D6E57" modified="2016-09-07" version="1">MIRDGDGKDAEELASSLCRYYEARNREDMDRLPRVTRENVLILKYYSFENYFLDPKIMEKIGVIKSEDDFYEILLKKWNEYLYKLKSGQHLTEMIGHALKNTTDIREHMEEIRICLRGHNLYDIFYGRFRKNETEILKSYIEEAPRDTFKDILDAIDRFVYFENRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X323</accession>
    <name>A0A173X323_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative selenium-dependent hydroxylase accessory protein YqeC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yqeC</name>
        <name evidence="4" type="ORF">BWLFYP14_02688</name>
        <name evidence="1" type="ORF">ERS852478_00192</name>
        <name evidence="3" type="ORF">GT712_00500</name>
        <name evidence="2" type="ORF">GT728_06035</name>
    </gene>
    <organism evidence="1 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 8">BIOML-A1</strain>
            <strain evidence="3 7">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055059498.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46103">
        <property type="protein sequence ID" value="CUN46103"/>
        <property type="gene ID" value="ERS852478_00192"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017587">
        <property type="entry name" value="YqeC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19842">
        <property type="entry name" value="YqeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03172">
        <property type="entry name" value="TIGR03172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN46103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL32777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZS87607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX66315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="238" mass="26928" checksum="88D7B68A23D821CB" modified="2016-09-07" version="1">MKHQVDFLELLQIDYEKYPVIAVVGGGGKTSLIYRLTDELIDKGKRVIITTTTHMAGESELPFARGGDAVRVKELLDKERYVIAAEYEEDTGKYASLTDEKLEELRELCDVMLVEADGAKHHPVKVPEKWEPVIPRCADIVISVIGLDCLGQPISQSAYRMERTSEFLRKSLEAPITEEDIVKIATSICGLFKDVEERVYRVYLNKSDILKEKEPAEHIVEELERKNTVAAYGSLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X445</accession>
    <name>A0A173X445_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Stage III sporulation protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">spoIIIE</name>
        <name evidence="14" type="ORF">ERS852478_00172</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Homohexamer. Forms a ring that surrounds DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN45587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199507.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN45587">
        <property type="protein sequence ID" value="CUN45587"/>
        <property type="gene ID" value="ERS852478_00172"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="13">
        <location>
            <begin position="551"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="333"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="351"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="568"/>
            <end position="575"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUN45587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="896" mass="99022" checksum="129F34EBD8CCF7C8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173X4C3</accession>
    <name>A0A173X4C3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">YfhO family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_00208</name>
        <name evidence="3" type="ORF">GT728_05955</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN46591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000010">
        <property type="protein sequence ID" value="MZL32761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381057.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN46591">
        <property type="protein sequence ID" value="CUN46591"/>
        <property type="gene ID" value="ERS852478_00208"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4485">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018580">
        <property type="entry name" value="Uncharacterised_YfhO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38454">
        <property type="entry name" value="PTHR38454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09586">
        <property type="entry name" value="YfhO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
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            <end position="319"/>
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            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="887"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN46591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="911" mass="104334" checksum="8D04C7F7CD7D7DF3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XL26</accession>
    <name>A0A173XL26_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Maltodextrin-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Multiple sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">malE</name>
        <name evidence="6" type="synonym">msmE_4</name>
        <name evidence="6" type="ORF">BWLFYP14_01990</name>
        <name evidence="5" type="ORF">ERS852478_00371</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199588.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52572">
        <property type="protein sequence ID" value="CUN52572"/>
        <property type="gene ID" value="ERS852478_00371"/>
    </dbReference>
    <dbReference type="GeneID" id="66496001"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022387">
        <property type="entry name" value="Bind_CPR0540"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006061">
        <property type="entry name" value="SBP_1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03850">
        <property type="entry name" value="bind_CPR_0540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01037">
        <property type="entry name" value="SBP_BACTERIAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033252394" evidence="4">
        <location>
            <begin position="28"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN52572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX65399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="448" mass="49287" checksum="B3FAA6B1AC15D09A" modified="2016-09-07" version="1">MKKRFAASAMILAMSAATVLSPLTAFAEAEEQELNIAIFQGGYGDAYWNQMVELFEESHEGVKVNMTISPTIGDIIRPQIVAGNAPDFICLNDGGEDGVILSLIKDHALLNLDDVFDGENYAGTGTLRDDITDGILSSTKCAPYGDDEIYLAPFNSGPQGLIYNKTFFDENNLEVPKTWDEFFALGDKVKDIDGRALFTYQGIYPGYMEEMLWPAIANECGEEALTKIANYEEGSFNNEGVLKALSHIKEIADKGYLLEGTVGMNHTESQTEMMLGKAAFITNGTWMENEMQDAPREDGFEFAMATIPTENADDVHYVFDSCEQFSIPAAAKNPELAKEFLRFLYSDESVSAFAEASGALYATKSAREVAKDKLSTAIYNMYGIYEEANASSLIMSFAAVPADCKVNPKDEIFNPITSVMNDEMTVEEWAQNVEDAFAQVRADMEAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XNE5</accession>
    <name>A0A173XNE5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted permease, DMT superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EamA transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN51948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199583.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPE010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN51948">
        <property type="protein sequence ID" value="CUN51948"/>
        <property type="gene ID" value="ERS852478_00351"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="149"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN51948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="285" mass="31100" checksum="20FA23750723ECB1" modified="2016-09-07" version="1">MWILFAFGSALFAGLTAILAKCGIRNTDSNVATALRTGVVLVFSWLMVFVVGAQSGIRDISAKVLIFLILSGLSTGISWLCYFKALQIGDINKVTPIDKSSTVITMLLAFIFLREEITWLKFVSMILIGIGTYLMIQKKETKEKAEDKKWLLYAVGSAVFASLTSILGKIGIQDVNSNLGTAIRTAVVWVMAWIVVFVTGKQNTVNNIDRKSWLFLILSGFATGGSWLCYYRALQTGPASVVVPIDKLSILVTIAFSYIVFHEKLSLKSGTGLLLIVVGTLALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XQT2</accession>
    <name>A0A173XQT2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyn operon transcriptional activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cynR_1</name>
        <name evidence="3" type="ORF">ERS852478_00429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199640.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000002.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN54282">
        <property type="protein sequence ID" value="CUN54282"/>
        <property type="gene ID" value="ERS852478_00429"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN54282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="294" mass="33855" checksum="0B2FA1744BEBE156" modified="2016-09-07" version="1">MDTNVLKTFIAVCEYAGFSAAAKELGYTQSTVSSQIKQLEKELDVRLFDRYYHKINLTEKGVLVLQQARNILKAQAKMLDSLNSAESIEGEIRLSMSSSVCSRYFKNDFLRFHHQYPEIKVEITENGTEQMFDKLRKNETDLVFTLDRHIYDSDFIICAEQEEQVHFIAAADNPVAGCSWKLSEISQNEFVLTEQAMSYRKILNETLASQSLEIRPVLEIGNPLQICELVKNSSLLSFLPDFISEKYVKDGQIKRLDVAGCPVTVWTQLLLHKNKWRSPAINVFIEFYKEVMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XSR5</accession>
    <name>A0A173XSR5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_00399</name>
        <name evidence="2" type="ORF">ERS852523_01589</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
            <strain evidence="2 4">2789STDY5834911</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN53398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000013">
        <property type="protein sequence ID" value="CUP42728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN53398">
        <property type="protein sequence ID" value="CUN53398"/>
        <property type="gene ID" value="ERS852478_00399"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP42728">
        <property type="protein sequence ID" value="CUP42728"/>
        <property type="gene ID" value="ERS852523_01589"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032UCT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN53398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUP42728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="70" mass="8208" checksum="2F07FD5319E1E014" modified="2016-09-07" version="1">MEQLGKYGFLRRDYLKNLKKKLTTLQAQDAEIRIYEEKIHHIADKMISIDLDDGVKKNCAIFQDVLAKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y372</accession>
    <name>A0A173Y372_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">ERS852478_00538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN58612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199697.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN58612">
        <property type="protein sequence ID" value="CUN58612"/>
        <property type="gene ID" value="ERS852478_00538"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008015869" evidence="3">
        <location>
            <begin position="29"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUN58612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="221" mass="24254" checksum="DA14C17D79FF1F0B" modified="2016-09-07" version="1">MNKTIKKLLSLFIAITVTLSLSITNYAAEQSILVAKIESLVKKAEKEIDQYGEASDATIAKLNSALDELGIEQGSYSDNQLIVVNDSITPYGYGETHTLKRGWTYRVDKPSTSDAKPHVHVDNNKKGIHGVENVDGTPSHGKTLGNSNVPKDVQDEVKKSRDYKKGQSDLNKMRKAKSEISRRHINLKKYKGRIIAAGIFVVIVGVAFFSPAFLPTALGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YCN8</accession>
    <name>A0A173YCN8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hemN</name>
        <name evidence="11" type="ORF">ERS852478_00603</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000003">
        <property type="protein sequence ID" value="CUN60725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN60725">
        <property type="protein sequence ID" value="CUN60725"/>
        <property type="gene ID" value="ERS852478_00603"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUN60725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="380" mass="43545" checksum="90F5DBCCBD3AE7A3" modified="2016-09-07" version="1">MERRNITDSPMEIYVHIPFCIKKCDYCDFLSGPSGPKEQADYVDALLEEINAAEEGKGRSVSSVFIGGGTPSVLDERFIGEILNHIRRKFQIADHAEITIEVNPGTADRNKLQAYRTYGINRLSIGLQSPDDRELKILGRIHNYEQFLETYRSAREAGFDNINIDLMSAIPDQTYEGWIHNLRTVAGLDPEHISAYSLIIEEGTPFASRTLNLPDEDAEYNMYEATAQILREYGFEQYEISNYAKKGRKCRHNVGYWIRQDYLGFGLGASSLYGKERFANTQDMKKYLENSRTPEKIREKEPPLTREDEMAEFMFLGLRMTRGISKAEFERQFGSEIDAIYGDVLRKYKSMGLLLEEKGRIFLSRDGIHVSNSVMADFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YJC2</accession>
    <name>A0A173YJC2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pcrA</name>
        <name evidence="9" type="ORF">ERS852478_00659</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN63670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380273.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63670">
        <property type="protein sequence ID" value="CUN63670"/>
        <property type="gene ID" value="ERS852478_00659"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005751">
        <property type="entry name" value="ATP-dep_DNA_helicase_PcrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01073">
        <property type="entry name" value="pcrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="6"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="287"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN63670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="744" mass="85212" checksum="40DCCC61F82DE9F4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YJT3</accession>
    <name>A0A173YJT3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclodextrin-binding protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cycB_1</name>
        <name evidence="2" type="ORF">ERS852478_00665</name>
        <name evidence="3" type="ORF">GT728_03605</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN63850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199747.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN63850">
        <property type="protein sequence ID" value="CUN63850"/>
        <property type="gene ID" value="ERS852478_00665"/>
    </dbReference>
    <dbReference type="GeneID" id="66493437"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033731538" evidence="1">
        <location>
            <begin position="24"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN63850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="418" mass="45472" checksum="9B01E140120F3ABF" modified="2016-09-07" version="1">MKKTLFTATLLAASLMAASTVQAAPQEVTMWHYFDQKPEQEMLADMVEEYNSLQDDIHINATFVSRTELMNQYTVGALSGELPDIGQVDSPDMESYISLGVFEDITDELESWGELDQFYDGPLSSCKDPDGKVYGLPQNSNCLALACNMDLLKAAGYDHMPQSLDEFKEMVAATTDASNDVYGFAMCAVSTEEGTFQILPWLRSVQNGTGVNVDNITADSAVNGLQTLGDFVANGYMSKECVNWTQADAWNQFCAGKAAFAECGTWHLAQTDAINGAFEYDFTLLPTGDEGTSTSTIGGENFGVCKGSENKEACAKFLEWLCSQENEAKWAAVGGKIPTRQDATAEYTFEQDGFKVFTDEMNYAQARGPHAEWPSISEAVYTATQSVIVDGTSAKDALETAAAKINPIVEETPLPESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173YRU4</accession>
    <name>A0A173YRU4_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">16S rRNA (cytosine(967)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">16S rRNA m5C967 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">rRNA (cytosine-C(5)-)-methyltransferase RsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rsmB</name>
        <name evidence="16" type="ORF">BWLFYP14_01788</name>
        <name evidence="13" type="ORF">ERS852478_00733</name>
        <name evidence="15" type="ORF">GT712_03090</name>
        <name evidence="14" type="ORF">GT728_03835</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 17">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="14 19 20" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 20">BIOML-A1</strain>
            <strain evidence="15 19">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42748"/>
            <dbReference type="Rhea" id="RHEA-COMP:10219"/>
            <dbReference type="Rhea" id="RHEA-COMP:10220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.176"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.176" evidence="4"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN66183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000006">
        <property type="protein sequence ID" value="MZL32347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000004">
        <property type="protein sequence ID" value="MZS88097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706499.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN66183">
        <property type="protein sequence ID" value="CUN66183"/>
        <property type="gene ID" value="ERS852478_00733"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004573">
        <property type="entry name" value="rRNA_ssu_MeTfrase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00563">
        <property type="entry name" value="rsmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="12">
        <location>
            <begin position="175"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="11">
        <location>
            <begin position="265"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUN66183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZL32347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZS88097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="VUX65002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="450" mass="51532" checksum="B4BCF3D0B482B801" modified="2016-09-07" version="1">MTNGINTRELILQILLEIEEEGKHSHIAIRNALSKYQFLPRQERAFITRVCEGTLEYRILIDYIIDSYSKVSVDKMKPVIREILRSAVYQIRFMDSVPDSAVCNEAVKLAQRKGFYSLKPFVNGVLRTIAREWKNLKLPSREENPVRYLSVRYSMPETLVNRWLEDYGEEKTEKILTDFLTEKPITVRCRTHKYPQKEIYESLVDQGVEVKPAPYLPYAYEISNYNHILALDAFIQGKIQVQDVSSMLVAEIADPQKGDYVIDMCAAPGGKSLHVADKMGDYGTVDARDISQYKVDMIEENIHRTDCINVQAHVMDATVFDVDSELKADVVLADVPCSGYGVIGKKPEIKYRVTAQKQEEIVILQRTILDNAAEYVKPGGVLVFSTCTIAKEENEENMLWFMNNHPFKLESIDPYLPEELHSETTALGYLQLLPGVHKTDGFFIAKFRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z0C0</accession>
    <name>A0A173Z0C0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Preprotein translocase subunit TatB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Selenium metabolism protein YedF</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">SirA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_00627</name>
        <name evidence="3" type="ORF">ERS852478_00840</name>
        <name evidence="4" type="ORF">GT712_14235</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000031">
        <property type="protein sequence ID" value="MZS90195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000006">
        <property type="protein sequence ID" value="VUX62849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380030.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000030.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69911">
        <property type="protein sequence ID" value="CUN69911"/>
        <property type="gene ID" value="ERS852478_00840"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN69911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="VUX62849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="68" mass="7578" checksum="89903627A8ECF15A" modified="2016-09-07" version="1">MKKVDARGLSCPEPVIRAKNAMESGDKEYEILVDNVVAKENVSRFATHQGYQVQATEQGDDILLKLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Z352</accession>
    <name>A0A173Z352_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF3343)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_00626</name>
        <name evidence="2" type="ORF">ERS852478_00839</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN69876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000006">
        <property type="protein sequence ID" value="VUX62848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN69876">
        <property type="protein sequence ID" value="CUN69876"/>
        <property type="gene ID" value="ERS852478_00839"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5030954">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021778">
        <property type="entry name" value="Se/S_carrier-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11823">
        <property type="entry name" value="DUF3343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3343" evidence="1">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN69876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX62848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="80" mass="9164" checksum="60643B80CF72E77C" modified="2016-09-07" version="1">MITYIATFYSHYGAIQFRRNCQAMNLSAEVMPVPRDLSSSCGTCVRFHTEADFPEKTEEVEQIVRVEPQGYVGIYHADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZHF5</accession>
    <name>A0A173ZHF5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">exo I</name>
        <name evidence="7" type="ORF">ERS852478_00970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN74648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199858.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN74648">
        <property type="protein sequence ID" value="CUN74648"/>
        <property type="gene ID" value="ERS852478_00970"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041063">
        <property type="entry name" value="Glyco_H_20C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="PTHR21040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18088">
        <property type="entry name" value="Glyco_H_20C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="103"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_H_20C_C" evidence="6">
        <location>
            <begin position="432"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN74648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="637" mass="73081" checksum="89CE301DABB61DC6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZJ70</accession>
    <name>A0A173ZJ70_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BlaI/MecI/CopY family transcriptional regulator</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Penicillinase repressor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Regulatory protein BlaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">blaI_2</name>
        <name evidence="4" type="synonym">blaI_1</name>
        <name evidence="4" type="ORF">BWLFYP14_01392</name>
        <name evidence="2" type="ORF">ERS852478_01017</name>
        <name evidence="3" type="ORF">GT728_13565</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BlaI transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN76274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000034">
        <property type="protein sequence ID" value="MZL34205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000032">
        <property type="protein sequence ID" value="VUX64417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN76274">
        <property type="protein sequence ID" value="CUN76274"/>
        <property type="gene ID" value="ERS852478_01017"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005650">
        <property type="entry name" value="BlaI_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34134">
        <property type="entry name" value="PTHR34134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03965">
        <property type="entry name" value="Penicillinase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019455">
        <property type="entry name" value="CopR_AtkY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN76274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL34205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="122" mass="13992" checksum="2A600CA156282148" modified="2016-09-07" version="1">MTEENIKLFDSELKVMDVLWKDGDVPAKYVADTLNREVGWNKNTTYTLIKRCINKGAIERTEPGFMCHALIAKEQVQDLETDELIDKIYDGSVDKLFAALLGRKKLSMEQIKNLKQIVSELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZLB3</accession>
    <name>A0A173ZLB3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sce7725 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01007</name>
        <name evidence="2" type="ORF">GT728_13520</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000005">
        <property type="protein sequence ID" value="CUN75975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000034">
        <property type="protein sequence ID" value="MZL34196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707126.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN75975">
        <property type="protein sequence ID" value="CUN75975"/>
        <property type="gene ID" value="ERS852478_01007"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZAXQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN75975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MZL34196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="310" mass="35837" checksum="6C5EFC1445AB633B" modified="2016-09-07" version="1">MYFPYLRGRQFELIALRELLEGKRISEKVIPIIEPVKPSSTLLKTLETFVKNDREIAVVFNPTVGDFAKKLKEMREEDSKVANELYDLLTQNDKVIKSYIMDRGILSEIKSEASKNKYLIINLNRDCLDDFLDAYEDTLPRFTLIPDDRAFRRVIPDSKVLFEDNFNKQSRNIDYIDNQDEFFSDSHLYYQNENYVGFADYSVVGEEFNESGFAPVAVAIHVVYFDKKKELRIHHFVSDSNEGIEDPGGKFGEALEKLVYWCDENNVQNTLGLQGFYDCYSSGKYPGLGTVKKYSIMHHIELVSNFLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZR30</accession>
    <name>A0A173ZR30_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 19" type="primary">uvrB</name>
        <name evidence="20" type="ORF">BWLFYP14_00340</name>
        <name evidence="19" type="ORF">ERS852478_01060</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 21">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN78704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707386.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITN010000033.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN78704">
        <property type="protein sequence ID" value="CUN78704"/>
        <property type="gene ID" value="ERS852478_01060"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:excinuclease repair complex"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="3"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="UVR_dom"/>
    </dbReference>
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        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
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        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
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    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="25"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="429"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="16">
        <location>
            <begin position="621"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="617"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CUN78704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="VUX67495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="662" mass="75561" checksum="C50CBE79B0779266" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173ZZT5</accession>
    <name>A0A173ZZT5_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="18 19">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="18">Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha</fullName>
                <shortName evidence="18">ACCase subunit alpha</shortName>
                <shortName evidence="18">Acetyl-CoA carboxylase carboxyltransferase subunit alpha</shortName>
                <ecNumber evidence="18">2.1.3.15</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta</fullName>
                <shortName evidence="19">ACCase subunit beta</shortName>
                <shortName evidence="19">Acetyl-CoA carboxylase carboxyltransferase subunit beta</shortName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="19 22" type="primary">accD</name>
        <name evidence="18" type="synonym">accA</name>
        <name evidence="22" type="ORF">ERS852478_01147</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 19">Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="function">
        <text evidence="18">Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="19">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Acetyl-CoA carboxylase is a heterotetramer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits of ACCase subunit beta/alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the AccA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the AccA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="18"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055199939.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81831">
        <property type="protein sequence ID" value="CUN81831"/>
        <property type="gene ID" value="ERS852478_01147"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0777">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00823">
        <property type="entry name" value="AcetylCoA_CT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01395">
        <property type="entry name" value="AcetylCoA_CT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041010">
        <property type="entry name" value="Znf-ACC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17848">
        <property type="entry name" value="zf-ACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00513">
        <property type="entry name" value="accA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00515">
        <property type="entry name" value="accD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="22" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="20">
        <location>
            <begin position="29"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="21">
        <location>
            <begin position="290"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="19">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CUN81831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="571" mass="63288" checksum="E9A1DC8760E8AEC0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A2Y9</accession>
    <name>A0A174A2Y9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fe-S cluster assembly scaffold protein NifU</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">NifU-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nifU</name>
        <name evidence="6" type="ORF">BWLFYP14_03050</name>
        <name evidence="2" type="ORF">ERS852478_01184</name>
        <name evidence="3" type="ORF">ERS852523_00504</name>
        <name evidence="5" type="ORF">GT712_03680</name>
        <name evidence="4" type="ORF">GT728_00275</name>
    </gene>
    <organism evidence="2 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP08461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704067.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2119"/>
    <dbReference type="EnsemblBacteria" id="CUN83052">
        <property type="protein sequence ID" value="CUN83052"/>
        <property type="gene ID" value="ERS852478_01184"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08461">
        <property type="protein sequence ID" value="CUP08461"/>
        <property type="gene ID" value="ERS852523_00504"/>
    </dbReference>
    <dbReference type="GeneID" id="66494019"/>
    <dbReference type="eggNOG" id="COG0822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017787">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03419">
        <property type="entry name" value="NifU_clost"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN83052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP08461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL31668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX66774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="149" mass="16434" checksum="4EBD6721D1007F1B" modified="2016-09-07" version="1">MAYSEKVMDHFQHPRNVGEIENASGVGTVGNAKCGDIMRIFLDIDDETHIIKDCKFKTFGCGAAVATSSMATEMVMGKTIEEAMEVTNKAVMEALDGLPPVKVHCSLLAEEAIHAALWDYAQKHHIEIKGLKKPKSDIHEGEEAEEEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A2Z8</accession>
    <name>A0A174A2Z8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="8">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">gltX</name>
        <name evidence="12" type="ORF">ERS852478_01148</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN81865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380849.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIUI010000003.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN81865">
        <property type="protein sequence ID" value="CUN81865"/>
        <property type="gene ID" value="ERS852478_01148"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="10">
        <location>
            <begin position="3"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="11">
        <location>
            <begin position="334"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="252"/>
            <end position="256"/>
        </location>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="255"/>
        </location>
        <ligand>
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        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
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        <source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00022917"/>
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            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
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            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUN81865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="483" mass="55724" checksum="DEAE318B3F7B2D75" modified="2016-09-07" version="1">MTKIRTRFAPSPTGRMHVGNLRTALYAYLITKHEGGDFILRIEDTDQERYVEGAVDIIYRTLAKTGLLHDEGPDKDKGFGPYVQSERQAQGIYLKYAQQLVEQGDAYYCFCKKEELEGMKRVVAGKEISIYDKRCLKLSKEEVQRRLDAGEPHVIRFNMPTEGTTTFHDVIYGDITVNNEELEDLILIKSDGYPTYNFANVIDDHLMEITHVVRGNEYLSSAPKYNRIYEAFGWDIPVYVHCPLITDETHQKLSKRCGHSSYEDLLDQGFVSEAIINYVALLGWSPSDNREIFTLDELVQVFDYHHINKSPAVFDIAKLRWMNGEYIKKMDADEFYERALPYMKEVLKKDYNFKKIAGMVQTRIETFPDIPALIDFFEEVPEYDSAMYCHKKMKTNEETSLTVLKEVLPVLEEQEDYTNDPLFETLSAFVKEHGYKNGYVMWPLRTAVSGKQMTPAGATEIMEIIGKDETIKRVKAAIEKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A6U2</accession>
    <name>A0A174A6U2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized vancomycin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_01199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN83609">
        <property type="protein sequence ID" value="CUN83609"/>
        <property type="gene ID" value="ERS852478_01199"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038054">
        <property type="entry name" value="LD_TPept-like_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022029">
        <property type="entry name" value="PG-bd_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12229">
        <property type="entry name" value="PG_binding_4"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="57"/>
            <end position="80"/>
        </location>
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            <end position="239"/>
        </location>
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    <feature type="domain" description="PG_binding_4" evidence="6">
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            <end position="373"/>
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            <begin position="393"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN83609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="521" mass="58202" checksum="F5A4E3A4A9ECBD9C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174A7F9</accession>
    <name>A0A174A7F9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thermostable beta-glucosidase B</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bglB_4</name>
        <name evidence="3" type="ORF">ERS852478_01214</name>
    </gene>
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        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN84237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NZ_CYZN01000006.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN84237">
        <property type="protein sequence ID" value="CUN84237"/>
        <property type="gene ID" value="ERS852478_01214"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
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    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="2">
        <location>
            <begin position="336"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN84237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="832" mass="93126" checksum="9EFD0FB0A82DEA9B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ACY5</accession>
    <name>A0A174ACY5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN86274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015560134.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000069.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN86274">
        <property type="protein sequence ID" value="CUN86274"/>
        <property type="gene ID" value="ERS852478_01240"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032SVU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN86274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="118" mass="12794" checksum="D0FC33A1C07F0FED" modified="2016-09-07" version="1">MKLFKKNENKKTTKLPMTGKVKKGFRYYCMAVMAMTFVLGTSVTAFAANDPIQVVNNLSDFIFGLVRAVGMIMLGFGIVQIGLSLKSHDPSQRANGFLTLAGGVVITFAKEILTLITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ACZ7</accession>
    <name>A0A174ACZ7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipoprotein-releasing system ATP-binding protein LolD</fullName>
            <ecNumber evidence="5">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lolD_3</name>
        <name evidence="5" type="ORF">ERS852478_01229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN85769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703421.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPP010000068.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN85769">
        <property type="protein sequence ID" value="CUN85769"/>
        <property type="gene ID" value="ERS852478_01229"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUN85769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="231" mass="25393" checksum="18A893A30EDD84D7" modified="2016-09-07" version="1">MEILKVQNLCKTYGTGEAKVDALKNVSFSLEKGEFVAVVGESGSGKSTLLNCIGALDVPTSGTVTMDGNNLFSMKEEERTIFRRRNIGFIFQSFQLVSELTVEQNIAFPLLLDYRKPKASDVEEILELLGLTERRNHLPSQLSGGQQQRVAIGRALITKPKLILADEPTGNLDSKNSQDVIDLLTKASRHYQQTILMITHNNGLTSMVDRVLRVTDGVLTDLGGNANEKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AT30</accession>
    <name>A0A174AT30_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitrous oxide-stimulated promoter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000007">
        <property type="protein sequence ID" value="CUN90626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200036.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPA010000055.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN90626">
        <property type="protein sequence ID" value="CUN90626"/>
        <property type="gene ID" value="ERS852478_01368"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020483">
        <property type="entry name" value="Uncharacterised_YgbA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11756">
        <property type="entry name" value="YgbA_NO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN90626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="113" mass="13764" checksum="B074832424396A95" modified="2016-09-07" version="1">MNKVEKKRQREQHVVEEMIQLYCRKNHSKEERQGRKMCPVCQELSDYAKLRSQKCPFMEQKTFCANCKVHCYKPEKREQICQVMRFSGPRMILYHPFLAVWHLICSKKEKRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174AZ12</accession>
    <name>A0A174AZ12_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pantothenate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">panF</name>
        <name evidence="8" type="ORF">ERS852478_01426</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200079.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93694">
        <property type="protein sequence ID" value="CUN93694"/>
        <property type="gene ID" value="ERS852478_01426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN93694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="459" mass="49181" checksum="74DB7FBD0EB8C8B0" modified="2016-09-07" version="1">MNGIIILFVYAVIMILATVTMTKKEKNVVNFCVGSRSENWILSALSIAATWIWAPALFVSTEKAYSAGWIGLFWFLVPNALCLVIFIPFAKRIRKEMPEGMTLSGYMKEKYSSDGVKRVYLFQLIGLSMLSTGVQLLAGSQILSAVTGISFRTMTILLAIIAISYSLFSGIKASMLTDAIQMVFMLIACSLFVIFGLRNTGAESILQGINGISGDYAKLFSGKGMEIFLSFGLPTTIGLISGPFGDQSFWQRAFAVKKEKLGRAFLLGAVLFAVVPLSMGILGLMGAGTGYQAQDLGTINFELIRHFFPSWAVLPFLFMIISGLLSTVDSNLCAVSSLTTDLSGGKDIRKTRTAMVVLLAAGILIANIPGITVTHLFLFYGTLRASTLLPTVLTLKGVRLTSGGIIAGVITSLAVGLPVFAYGSILNSGPYKTMGSLLTVLLSGLVTLIATRTEAGHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B2Y5</accession>
    <name>A0A174B2Y5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95064">
        <property type="protein sequence ID" value="CUN95064"/>
        <property type="gene ID" value="ERS852478_01468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN95064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="56" mass="6651" checksum="CBAB0E0742AFDA20" modified="2016-09-07" version="1">MTKLQIISKQWSLIYDLLLLNKGASERTLDEIEQDMDTLEFHCRKYVEADDEELMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B302</accession>
    <name>A0A174B302_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN93998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200084.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN93998">
        <property type="protein sequence ID" value="CUN93998"/>
        <property type="gene ID" value="ERS852478_01437"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN93998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="142" mass="14534" checksum="3EDD2093A900027B" modified="2016-09-07" version="1">MGTNFNGTMINQSVTIAEKAGADIADVRNLILKYDEDGNVVIAANGTAPLLGLSIIEGGYNDISGAESGKVKKGDDLEIQIKDIGYAIASAEIKKGQEVTAATGGKAAVAKAGEYVIGVALNSVSAGGYSRIQIAKYQKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B752</accession>
    <name>A0A174B752_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein conserved in bacteria</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381000.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN96782">
        <property type="protein sequence ID" value="CUN96782"/>
        <property type="gene ID" value="ERS852478_01516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN96782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="287" mass="32522" checksum="53880CF28FE7005B" modified="2016-09-07" version="1">MDISDFVKKAKEYNVLGIKISKDNELAAEWYSEPECRRNIYSATKSFTSCAVGFAVQEGLIDLNEKLTEAFSGDLPECIDENLKEATVRDLLTMCLGQEKGSLMGEQRPLYEEDNWVKMSLAIPFKYKPGTHFVYNNVGPYLAGILVQRRSGCDLVSYLTSRLFSKIGIKRPTWETDPLGNSFGAGGLFLTLSELHKFGLFYLNKGKWNGKQILSEKWIEESTKAADVGYYGYLFWRGEYNSFRADGKYSQISMILPKKNAVVSFVSECRRGDELLKTVYELVCAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BBX8</accession>
    <name>A0A174BBX8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN97679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200133.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN97679">
        <property type="protein sequence ID" value="CUN97679"/>
        <property type="gene ID" value="ERS852478_01539"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN97679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="104" mass="11996" checksum="D19CC86E9CDFE8CD" modified="2016-09-07" version="1">MRTGLTKQEKTTDIWFDEKEPLIHIRTHNTDLKKRLAAYAGQHPDQCRQTDADPDTGCMEFEIRKGRFSFRLTAPYSEERRNAASKAAKKHSGNLTHPIQKDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BFY3</accession>
    <name>A0A174BFY3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUN99941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057301.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN99941">
        <property type="protein sequence ID" value="CUN99941"/>
        <property type="gene ID" value="ERS852478_01581"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN99941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="132" mass="15391" checksum="12FEB5A928419380" modified="2016-09-07" version="1">MRERIESKHVTKEIKSQMPVIPGAIVKERGCTFCPYYLGNYEKQPRCMMKTCAWDDENERFHPVLRGLIPFYKEKMEKAEEKFLAMKKIYTTLLGMFAAEMKQEELEKDECYGCAYGKCGPCIGICYKSMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BJ24</accession>
    <name>A0A174BJ24_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">ERS852478_01599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO00543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055057312.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO00543">
        <property type="protein sequence ID" value="CUO00543"/>
        <property type="gene ID" value="ERS852478_01599"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="2103"/>
            <end position="2277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2503"/>
            <end position="2560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1829"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="2519"/>
            <end position="2560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO00543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="2560" mass="292292" checksum="C4A1B135014A366F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BRE4</accession>
    <name>A0A174BRE4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stage V sporulation protein AA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200160.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000009.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02208">
        <property type="protein sequence ID" value="CUO02208"/>
        <property type="gene ID" value="ERS852478_01646"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502ZCB6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021997">
        <property type="entry name" value="SporV_AA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038548">
        <property type="entry name" value="SporV_AA_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12164">
        <property type="entry name" value="SporV_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="SporV_AA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO02208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="204" mass="23147" checksum="D28146E0D6D58C7A" modified="2016-09-07" version="1">MSDTLYLQLDQNIQINHPHIYLQDIAKLSCSNSKILNRLRVMPVINLDPNKPGRYVMSVMDLISEIKKKEPDLEINNIGEADFIITFKNKPGPGLVWQWCKIIFVGLAAFFGAGFSIMTFNNDVDVGGLFSQIYTQVTGQTSGHFTVLEITYSIGIGLGVLFFFNHFGHIKITDDPTPMQIQMRLYEENVNKTLIKDIDRTSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BS81</accession>
    <name>A0A174BS81_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein ERS852478_01652</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yvcJ</name>
        <name evidence="3" type="synonym">rapZ</name>
        <name evidence="2" type="ORF">ERS852478_01652</name>
        <name evidence="3" type="ORF">GT728_04665</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO02416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579633.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO02416">
        <property type="protein sequence ID" value="CUO02416"/>
        <property type="gene ID" value="ERS852478_01652"/>
    </dbReference>
    <dbReference type="GeneID" id="66496115"/>
    <dbReference type="eggNOG" id="COG1660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO02416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="295" mass="33789" checksum="168A63A9469BE16E" modified="2016-09-07" version="1">MRFVIVTGVSGAGKTSALKMLEDAKYFCVDNLPIPLLEKFASLMPEIHGEDVQNVALGIDARSGRSLDELEIVLDRMKKAGYDFEILFLDAQDSVLVKRYKETRRSHPLAMGGRVDDGIRMEREKMRFLKERADYIIDTSNLLTRELKQEIDRIFVDNQDFCNMMISVLSFGFKYGIPADADLVFDVRFLPNPYYVDELRPLTGLDDRVFNYVMDCDIARAFADKLEDMINFLIPNYVKEGKTNLVIAIGCTGGKHRSVTLARELYSRLSGNTKYGFRLEHRDAQKDRLVRKQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BZL8</accession>
    <name>A0A174BZL8_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">guaA</name>
        <name evidence="15" type="ORF">BWLFYP14_01143</name>
        <name evidence="12" type="ORF">ERS852478_01707</name>
        <name evidence="14" type="ORF">GT712_06620</name>
        <name evidence="13" type="ORF">GT728_09875</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="13 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 19">BIOML-A1</strain>
            <strain evidence="14 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="15 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO04978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000020">
        <property type="protein sequence ID" value="MZL33497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000010">
        <property type="protein sequence ID" value="MZS88750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705330.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO04978">
        <property type="protein sequence ID" value="CUO04978"/>
        <property type="gene ID" value="ERS852478_01707"/>
    </dbReference>
    <dbReference type="GeneID" id="66492382"/>
    <dbReference type="eggNOG" id="COG0518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="197"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="224"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO04978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL33497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZS88750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="VUX63785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="525" mass="58329" checksum="87DF1C68E1ACAACF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174C8A2</accession>
    <name>A0A174C8A2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hsp20 family protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Probable Hsp20 family chaperone</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Putative Hsp20 family chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BWLFYP14_01217</name>
        <name evidence="4" type="ORF">ERS852478_01798</name>
        <name evidence="5" type="ORF">ERS852523_03609</name>
        <name evidence="6" type="ORF">GT712_11935</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">2789STDY5834863</strain>
            <strain evidence="5 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="6 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000057">
        <property type="protein sequence ID" value="CUQ01204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000030">
        <property type="protein sequence ID" value="VUX63868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705425.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000057.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000014_gene1238"/>
    <dbReference type="EnsemblBacteria" id="CUO07926">
        <property type="protein sequence ID" value="CUO07926"/>
        <property type="gene ID" value="ERS852478_01798"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ01204">
        <property type="protein sequence ID" value="CUQ01204"/>
        <property type="gene ID" value="ERS852523_03609"/>
    </dbReference>
    <dbReference type="GeneID" id="66495005"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="37"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO07926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUQ01204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS89762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX63868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="155" mass="17861" checksum="CD6C53EF48BFC76A" modified="2016-09-07" version="1">MLMPSIFGENLFDDFFGDFPFYYDDRAMKDAEKKLYGHKANHVMKTDIKEMNNGYELIVDLPGFKKDEVHAALENGYLTISAEKGLDKDEKEKETGRYIRRERYAGACSRSFYVGKEVHQDDIKAEFKHGILTLFVPKKEAKPAVEQKHSISIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CE38</accession>
    <name>A0A174CE38_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200421.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11383">
        <property type="protein sequence ID" value="CUO11383"/>
        <property type="gene ID" value="ERS852478_01886"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO11383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="138" mass="15997" checksum="421DCEF65BBD0853" modified="2016-09-07" version="1">MGYDIEKEKREAIEAGRRALNSLRTAKENLNSAKNWGLVDMFGGGFFTTLLKHSKMDQAKRNMEQAKYDLRSFSRELNDVNMACNLNINTGDFLSFADYFFDGFVVDWVVQDRINNAKRQVEEAIRRTESIVSQLQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CEZ3</accession>
    <name>A0A174CEZ3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">barA</name>
        <name evidence="8" type="ORF">ERS852478_01897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO11704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO11704">
        <property type="protein sequence ID" value="CUO11704"/>
        <property type="gene ID" value="ERS852478_01897"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="157"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="301"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO11704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="404" mass="45972" checksum="FF9259F8F2750C3B" modified="2016-09-07" version="1">MVLDEHKHNFDIHINHIEHEDVCGDSLRIQQVFVNLMSNAIKYTPDGGNIIFSIEEKPNGFSELGCYEFTIEDNGIGMSPEFQKIMFDPFSRADDHRTTRVQGTGLGMAISRNIVNLMNGNIKVDSTLHKGTRITVTIYLELQEKEKEQDENLMNLPVLVVDDDKTCCESTIATLKEIGITGEWVLSGREAVECCYARHELKNDYFAVILDWKMPEIDRIETARQIRKRIGKEITIIVLTSYEFSEIEEEAKAAGVDAFIAKPLFRSRLTATLRQFTSGRKEKTARNYLEELSESDYTGKRILLVEDNELNREIGVEILQMTRAEVETAENGKIAVEKVEASPKGSYDLIFMDIQMPVMNGYEATAAIRSLPGEKGKLPVTDFYVITKRITRNRVNSNIHTFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CKV3</accession>
    <name>A0A174CKV3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO13873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703609.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO13873">
        <property type="protein sequence ID" value="CUO13873"/>
        <property type="gene ID" value="ERS852478_01964"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039444">
        <property type="entry name" value="SIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041486">
        <property type="entry name" value="STALD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13289">
        <property type="entry name" value="SIR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18185">
        <property type="entry name" value="STALD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIR2_2" evidence="1">
        <location>
            <begin position="114"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="STALD" evidence="2">
        <location>
            <begin position="251"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO13873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="481" mass="55147" checksum="C9B4EFE44DBFC51A" modified="2016-09-07" version="1">MSSIYERLLTKTADQLPHFYKKFSDQIINNEASLFIGAGVSRNSGYPGWADLLSECAEELNVDLNKIDLYSLAQYYANEHSDSDLRSIINNKINKIPQESNLLLNSLLEIGFNSIWTTNYDKSIETELGKKCIPHNIIVNDKNLASIDCHDKVNIYKMNGDISEPINMILTKNDYEHYLKKHPLFLTFLKRELVSNTFLFIGYSFSDALVLDCLCSIQEFLGGSMEGHYAIMYIDENVSQDFYYFVEDLKKRYNITCLCASKDGMLNIINCLNGKTKEKKVFISGSYDSVTENTNNFADKLSCALVNHLYNSGYRISTGVGKRLGTYITGYANQYLAERNISNTPKYLSMRPFPFHMNLSEEKKETYRKLMQRDCSAAIFLFGQSRNMNKAGMFDDNIAHFSTGTYQEFQIAKANNFVIIPVGATGYEANIIWKEVKANINQFYYLSKKIDILRYETEPQKISEVIVNILNSVTEYRCIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CTY2</accession>
    <name>A0A174CTY2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ppk_2</name>
        <name evidence="6" type="synonym">ppk</name>
        <name evidence="12" type="ORF">ERS852478_02039</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO16961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200505.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000012.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO16961">
        <property type="protein sequence ID" value="CUO16961"/>
        <property type="gene ID" value="ERS852478_02039"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="9">
        <location>
            <begin position="12"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="8">
        <location>
            <begin position="128"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="11">
        <location>
            <begin position="344"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="10">
        <location>
            <begin position="516"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO16961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="722" mass="82634" checksum="4E906D47F3B94F74" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CWI2</accession>
    <name>A0A174CWI2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-galactopyranose mutase</fullName>
            <ecNumber evidence="5">5.4.99.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glf</name>
        <name evidence="6" type="ORF">BWLFYP14_00427</name>
        <name evidence="5" type="ORF">ERS852478_02007</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 7">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.9" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO15956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000003">
        <property type="protein sequence ID" value="VUX62336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025577203.1">
        <property type="nucleotide sequence ID" value="NZ_JAAITO010000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO15956">
        <property type="protein sequence ID" value="CUO15956"/>
        <property type="gene ID" value="ERS852478_02007"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0562">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008767">
        <property type="term" value="F:UDP-galactopyranose mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004379">
        <property type="entry name" value="UDP-GALP_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015899">
        <property type="entry name" value="UDP-GalPyranose_mutase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03275">
        <property type="entry name" value="GLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00031">
        <property type="entry name" value="UDP-GALP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GLF" evidence="4">
        <location>
            <begin position="148"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO15956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX62336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="371" mass="43515" checksum="F48A5D3F7452F618" modified="2016-09-07" version="1">MKKYDYLIVGAGLFGAVFAHEATRRGKTCLVIDKRGHIGGNIYTEEVEGIQVHRYGAHIFHTSRKQVWDYINQFAEFNHFVNSPIAVYKDELYNLPFNMNTFHQLWGVRTPAEAKAKIQEQIARMHITHPKNLEEQALALVGQDVYEKLVEGYTRKQWGRECKDLPAFIIKRLPLRYTYDNNYFKDPYQGIPKGGYTRIVKKLLEGVQVCLNTDFFANREELTAQADKVLFTGMIDEFYDYCYGELEYRSLRFETEVLDMGNYQGNAVVNYTDYEVPYTRIIEHKHFEFGTQPKTVITREYPAAWEKGKEPYYPVNDPKNSELFDKYERRALEEKNVIFGGRLGMYRYMDMDQVIEEALSLAETELTYEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174D7D7</accession>
    <name>A0A174D7D7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IS91 family transposase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Putative transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02114</name>
        <name evidence="4" type="ORF">GT712_19620</name>
        <name evidence="3" type="ORF">GT728_11595</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 7">BIOML-A1</strain>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO19970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000027">
        <property type="protein sequence ID" value="MZL33823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000084">
        <property type="protein sequence ID" value="MZS91176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO19970">
        <property type="protein sequence ID" value="CUO19970"/>
        <property type="gene ID" value="ERS852478_02114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007069">
        <property type="entry name" value="Transposase_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026889">
        <property type="entry name" value="Zn_Tnp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04986">
        <property type="entry name" value="Y2_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14319">
        <property type="entry name" value="Zn_Tnp_IS91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_Tnp_IS91" evidence="1">
        <location>
            <begin position="12"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO19970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL33823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS91176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="393" mass="45593" checksum="B14B297BAC5FF27D" modified="2016-09-07" version="1">MIMDKSCTIQDVFERFYPSYEKRSNPPAHHRKTAYHIRNCKTGVFGVNISVCEDCGCISVHNNSCRSRCCPMCQEFPKEKWIDAQKENVLDAPYYHVVFTVPEELNSIIYSNQKLLYDALYHAASATLNELSKDAKYLGADIGYICILHTWGSAMNYHPHIHTIVLGGGLDDENKWKETGGNFFLPYGVISKVFRGKYLDELKSLWNDSKLKFHGTAEKYQNSYRFKELLDKCYEKNWVTYCKETFNGAQSVINYLGKYTHRIAISNQRIKSMKDTTVTYAVKDYKNEGCWKEKTISGEEFIRRFLMHVPPKQFVRIRHYGLLSCRNKRKKITHCRNLLGCKKYISTLKNLNAIEMIKVLYHIDVCKCSSCGGNMVSPRKDKYSSSFCAHMRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DBP6</accession>
    <name>A0A174DBP6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spo0A_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_02162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000013">
        <property type="protein sequence ID" value="CUO21470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005334915.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO21470">
        <property type="protein sequence ID" value="CUO21470"/>
        <property type="gene ID" value="ERS852478_02162"/>
    </dbReference>
    <dbReference type="GeneID" id="43514246"/>
    <dbReference type="GeneID" id="64114176"/>
    <dbReference type="GeneID" id="66495324"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042173">
        <property type="term" value="P:regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014879">
        <property type="entry name" value="Spo0A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08769">
        <property type="entry name" value="Spo0A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spo0A_C" evidence="2">
        <location>
            <begin position="6"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO21470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="74" mass="8631" checksum="6A06E0ACB7872324" modified="2016-09-07" version="1">MLGIKKRDTKQVFKAIAHQQGVSVSEVKERIQSTIDEMYYSDDPDVQAEFSSYFGKKRPTPEEYVYTMATKIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174DWK0</accession>
    <name>A0A174DWK0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arogenate dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.43</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Prephenate dehydrogenase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Prephenate dehydrogenase/arogenate dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tyrC</name>
        <name evidence="7" type="ORF">BWLFYP14_02924</name>
        <name evidence="3" type="ORF">ERS852478_02351</name>
        <name evidence="4" type="ORF">ERS852523_01068</name>
        <name evidence="6" type="ORF">GT712_13790</name>
        <name evidence="5" type="ORF">GT728_07870</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.43" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000015">
        <property type="protein sequence ID" value="CUO28415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000008">
        <property type="protein sequence ID" value="CUP26307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000014">
        <property type="protein sequence ID" value="MZL33123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000029">
        <property type="protein sequence ID" value="MZS90115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000072">
        <property type="protein sequence ID" value="VUX66648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025576901.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000014.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000001_gene1070"/>
    <dbReference type="EnsemblBacteria" id="CUO28415">
        <property type="protein sequence ID" value="CUO28415"/>
        <property type="gene ID" value="ERS852478_02351"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP26307">
        <property type="protein sequence ID" value="CUP26307"/>
        <property type="gene ID" value="ERS852523_01068"/>
    </dbReference>
    <dbReference type="GeneID" id="66494239"/>
    <dbReference type="eggNOG" id="COG0287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047794">
        <property type="term" value="F:cyclohexadienyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO28415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP26307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL33123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS90115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="363" mass="40638" checksum="2A24D73A2309664B" modified="2016-09-07" version="1">MKTIGFIGLGLIGGSIAKAIRKYHEDYRLLAYDQDRETLAAAVSSNMIDAVCEEHDERFRSCDYIFLCAPVEFNVKYLEYFKDNIGPDTILTDVGSVKGIIHKEVERLGMESRFIGGHPMAGSEKTGFEASSDRLIENAYYIITPGGEVALERLTDFTEMISSLGAIPMVLTSEEHDFITAGVSHLPHIIASALVNLVNMLDSDQEYMKTIAAGGFRDITRIASSSPIMWEQICVENNQNISNVLDDYIRLLVQIKCFVDNKDSRSLYQMFASSRDYRDSIDVVDNGLLKKAYVLYLDIADEAGGIATIATILAMEKISIKNIGIIHNREFEEGVLKIEFYDGISMEKGAALLKKRNYIVYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E6M1</accession>
    <name>A0A174E6M1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_02453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO32096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO32096">
        <property type="protein sequence ID" value="CUO32096"/>
        <property type="gene ID" value="ERS852478_02453"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO32096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="116" mass="13659" checksum="7EC8FAC6ED7905E5" modified="2016-09-07" version="1">MYYEKETADKPEKWPANAREQILDTLCECVEKFEKNPSYKTREVLLSLTCEHDLNLNENFGLVRVTEYEVGILNFLYLVGNTYQISSLKTYIYNIIAEFLKFFVYRCHLQGGIGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174E8T0</accession>
    <name>A0A174E8T0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Autoinducer 2 ABC transporter permease LsrC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">ERS852478_02531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000016">
        <property type="protein sequence ID" value="CUO34081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380369.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000004.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO34081">
        <property type="protein sequence ID" value="CUO34081"/>
        <property type="gene ID" value="ERS852478_02531"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO34081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="305" mass="32850" checksum="6E696E87D1F58912" modified="2016-09-07" version="1">MQILTLITALPGAVAQGLIWGIMAIGVYITFRILDIADLTVDGTMCTGGAVCIMMMLSGHNVWISMLAATLAGMLAGLATGIFHTFMGIPAILAGILTQLSLYSVNLKIMGKANQAINVDKYNLLVSLRHIKNASLSKNTIFIVAVMCILLIAILYWFFGTELGCSLRATGCNPNMSRAQGINTNRNKVLGLMISNGLVGLSSALLAQYQGFADVNMGRGSIVIGLAAVIIGEAIFGRIFRNFALRLLAVIFGSILYYLVLQIVIWMGIDTDLLKMLSAIVVALFLAFPYWKGKYFNKPAKRGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EIA9</accession>
    <name>A0A174EIA9_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CO-methylating acetyl-CoA synthase</fullName>
            <ecNumber evidence="1">2.3.1.169</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cdhC</name>
        <name evidence="10" type="ORF">ERS852478_02583</name>
        <name evidence="11" type="ORF">GT728_02660</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 12">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.169" evidence="1"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000004">
        <property type="protein sequence ID" value="MZL32120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380764.1">
        <property type="nucleotide sequence ID" value="NZ_JADPEU010000043.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36169">
        <property type="protein sequence ID" value="CUO36169"/>
        <property type="gene ID" value="ERS852478_02583"/>
    </dbReference>
    <dbReference type="GeneID" id="66494130"/>
    <dbReference type="eggNOG" id="COG1614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018492">
        <property type="term" value="F:carbon-monoxide dehydrogenase (acceptor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043884">
        <property type="term" value="F:CO-methylating acetyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACS_CODH_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004461">
        <property type="entry name" value="CO_DH/Ac-CoA_synth_bsu"/>
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    <dbReference type="InterPro" id="IPR038571">
        <property type="entry name" value="CO_DH/Ac-CoA_synth_bsu_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041350">
        <property type="entry name" value="CODH_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42281">
        <property type="entry name" value="PTHR42281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19436">
        <property type="entry name" value="ACS_CODH_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03598">
        <property type="entry name" value="CdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18537">
        <property type="entry name" value="CODH_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00316">
        <property type="entry name" value="cdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0533">Nickel</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CODH_A_N" evidence="8">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="ACS_CODH_B_C" evidence="9">
        <location>
            <begin position="464"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO36169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL32120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="708" mass="77068" checksum="9DCD8BA37034076C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EMR2</accession>
    <name>A0A174EMR2_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein of uncharacterized function (DUF1292)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02631</name>
        <name evidence="3" type="ORF">ERS852523_02318</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
            <strain evidence="3 5">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CUO37908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000023">
        <property type="protein sequence ID" value="CUP64682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000055_gene1914"/>
    <dbReference type="EnsemblBacteria" id="CUO37908">
        <property type="protein sequence ID" value="CUO37908"/>
        <property type="gene ID" value="ERS852478_02631"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP64682">
        <property type="protein sequence ID" value="CUP64682"/>
        <property type="gene ID" value="ERS852523_02318"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG50338T3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO37908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP64682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="81" mass="9383" checksum="990CF2079F4EB953" modified="2016-09-07" version="1">MEEYEVISIPVSDGTERDFAIMDTFEFEGQGYLAVSLIEGDEIQEGVYIYRYHNAEDGDVVVEQITLPAEYKKVTKFYEQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174ET72</accession>
    <name>A0A174ET72_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S4 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO40487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200851.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000019.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO40487">
        <property type="protein sequence ID" value="CUO40487"/>
        <property type="gene ID" value="ERS852478_02708"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025490">
        <property type="entry name" value="RNAbp_HP1423"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038881">
        <property type="entry name" value="RNAbp_HP1423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO40487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="79" mass="9018" checksum="BF9F9AECE2576068" modified="2016-09-07" version="1">MRLDKYLKVSRLIKRRTVANEACDAGRVLVNDKPAKASVQVKMGDTIEIQFGSKNVKVEVLDVKETVKKEDVESMYKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EUK5</accession>
    <name>A0A174EUK5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BWLFYP14_00573</name>
        <name evidence="6" type="ORF">ERS852478_02729</name>
        <name evidence="7" type="ORF">ERS852523_02529</name>
        <name evidence="9" type="ORF">GT712_09820</name>
        <name evidence="8" type="ORF">GT728_09555</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000027">
        <property type="protein sequence ID" value="CUP70649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000019">
        <property type="protein sequence ID" value="MZL33437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000017">
        <property type="protein sequence ID" value="MZS89359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000005">
        <property type="protein sequence ID" value="VUX62795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707918.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000058_gene2545"/>
    <dbReference type="EnsemblBacteria" id="CUO41007">
        <property type="protein sequence ID" value="CUO41007"/>
        <property type="gene ID" value="ERS852478_02729"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP70649">
        <property type="protein sequence ID" value="CUP70649"/>
        <property type="gene ID" value="ERS852523_02529"/>
    </dbReference>
    <dbReference type="GeneID" id="66493319"/>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO41007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUP70649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL33437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS89359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX62795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="57" mass="5914" checksum="F5E13944DFBC081E" modified="2016-09-07" version="1">MAYVISDECVSCGTCESECPAEAISQGDEHYVIDADACLDCGTCADACPTEAIHPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EWS6</accession>
    <name>A0A174EWS6_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MTH538 TIR-like domain (DUF1863)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022379855.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPO010000111.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42234">
        <property type="protein sequence ID" value="CUO42234"/>
        <property type="gene ID" value="ERS852478_02763"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="40"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO42234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="196" mass="22655" checksum="2CF6FA17A9AD92B6" modified="2016-09-07" version="1">MAKDIFDKTIFDGYRVESLTESAQDIIPKYNFDGSTKTTVFISHKHDDLDETKGLIGLLERKYNIKAYIDSLDKSMPKKTSGETASKIKQRINRCNKFILLATNGAVESKWCNWELGYGDAQKFDTDNIALFPIKPDKTNDYDYKGNEYMRIYPHIAYYYGSERYSNGTVIKEGFYVCTDTENGRTIVPLEKWLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZK5</accession>
    <name>A0A174EZK5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable adenylyltransferase/sulfurtransferase MoeZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">moeZ_2</name>
        <name evidence="3" type="ORF">ERS852478_02777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO42717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055054156.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000020.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO42717">
        <property type="protein sequence ID" value="CUO42717"/>
        <property type="gene ID" value="ERS852478_02777"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="ThiF" evidence="2">
        <location>
            <begin position="11"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO42717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="278" mass="30343" checksum="7FCB8AEE3D9C8E9D" modified="2016-09-07" version="1">MAMTDEQIERYSRHIILKEVGAKGQKKLLKGKVLIIGAGGLGAPAAMYLAAAGVGTIGIVDADEVDLSNLQRQIIHSTTDIGKAKVKSAKETMNAMNPDVEVKTYRMFVDASNIRELIREYDFIIDGTDNFPAKFLINDACVLEKKPFSHAGIIRFKGQLMTYVPGEGPCYRCVFKNPPPKDAVPTCKQAGVIGAMGGVIGSLQAMEAIKYLIGVGDLLTGYLLTFDALTMEFHKVKLPKDTHDCAVCGDHPTILEPIDYEQEVCEETAGRFATRDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EZL1</accession>
    <name>A0A174EZL1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Galactokinase</fullName>
            <ecNumber evidence="7">2.7.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">galK</name>
        <name evidence="7" type="ORF">ERS852478_02804</name>
        <name evidence="9" type="ORF">GT712_17330</name>
        <name evidence="8" type="ORF">GT728_08480</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">BIOML-A1</strain>
            <strain evidence="9 11">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.6" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000016">
        <property type="protein sequence ID" value="MZL33230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000050">
        <property type="protein sequence ID" value="MZS90769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025581048.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43423">
        <property type="protein sequence ID" value="CUO43423"/>
        <property type="gene ID" value="ERS852478_02804"/>
    </dbReference>
    <dbReference type="GeneID" id="66494723"/>
    <dbReference type="eggNOG" id="COG0153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="6">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="134"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO43423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL33230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS90769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="412" mass="45318" checksum="30284427DE7F6911" modified="2016-09-07" version="1">MNIPNKNELTRIYGEAEKSAARFQAVADHFAEIYHHDIAEFFTAPGRTEIIGNHTDHNGGRVIAGSIDMDTIGAAYPNNSSVIRITSEGYDKEVVVDINDLASVPKAQGTVSLVAGMVEAIQKFGFKVAGFDAYVTTNVIRAAGVSSSASFEMLVCSIINYFFNDGAMTYINYAKAGQYAENVYWLKASGLMDQLACAVGGPILLDFSDRENPKYEKVNFSFHDYDHHLVIVNTGKGHADLSEEYSEIPMEMKEAAKAAGAELLCETTLDKVLANMDKIDNDRAILRAIHFFKENERVERAAKAVEEKDGETVLKLLSESGKSSWELLQNCYPIKAYTEQKISVALALTDLFLEKLGKGICRIHGGGFAGVIMCVVPEEETENYVSYISEFAGKENVYPMNIRAVGAVHIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F032</accession>
    <name>A0A174F032_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000019">
        <property type="protein sequence ID" value="CUO41650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO41650">
        <property type="protein sequence ID" value="CUO41650"/>
        <property type="gene ID" value="ERS852478_02752"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG5032YIB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025648">
        <property type="entry name" value="DUF4358"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14270">
        <property type="entry name" value="DUF4358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO41650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="171" mass="19260" checksum="61824A5D193B8632" modified="2016-09-07" version="1">MADKYGTDCGVKGMKNYLHIFIKGAFVLFLIAYLTVLYTSDSAKNVPMEQIAQTMEQDSDITSLNKETRSDLKHYYQTDDRNIDGYFFYKAASPMAVEEICIMKATDNTQANTLLENANAHLSSQKQVFEGYGTDQMALLNNAVVGKKGNYVYYMCGADAQNWRTAFLSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F4Y0</accession>
    <name>A0A174F4Y0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-fructosidase</fullName>
            <ecNumber evidence="7">3.2.1.26</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="8">DUF4975 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">bfrA_1</name>
        <name evidence="7" type="ORF">ERS852478_02797</name>
        <name evidence="9" type="ORF">GT712_15300</name>
        <name evidence="8" type="ORF">GT728_08450</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="7 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="8 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 12">BIOML-A1</strain>
            <strain evidence="9 11">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000016">
        <property type="protein sequence ID" value="MZL33224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000036">
        <property type="protein sequence ID" value="MZS90398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025580901.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000016.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO43235">
        <property type="protein sequence ID" value="CUO43235"/>
        <property type="gene ID" value="ERS852478_02797"/>
    </dbReference>
    <dbReference type="GeneID" id="66494814"/>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="5">
        <location>
            <begin position="21"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="6">
        <location>
            <begin position="322"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUO43235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL33224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS90398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="463" mass="53852" checksum="C126B5EA7141DCF9" modified="2016-09-07" version="1">MQKLYYQFPGTWFGDCMPFGHGDKFYLYHQRDTRKPGPFGEPFGWDLATTSDFVHYEDKGVAIPRGTDEEQDQFIFAGSVFEAEGQYHIFYTGYNRDYPALGKPSQVLMHAYSDDLVTWHKTQDALTFTPQEGYDPDDWRDPWVIRDEENDQYLLILGARLQGPKTRQTGRTVKFTSKDLKNWKFEGDFWAPDLYTMHEMPDLFKIGDWWYHIVTEYSDRSKMVYRMSKSLEGPWIAPKDDAFDGRSYYAGRTFELNGQRILFGWVATKDQDDDDNNFIWAGTFMAHEVYQREDGTLGVRIPETVWNAFDKEEKTEDFVIDTPTKSTEKVVAKDTGDIFKFEADVEFTEGTRTFGVRFYEDEDKAESYQFVFNVTEDRYVFEKKPNWPWPANQNIGLERPLELVPGKKYNIKMIVDDTIATIYVDGVALNARAYKRPGESLSLFASEGSLKVTNCKVTTGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FS66</accession>
    <name>A0A174FS66_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Omega-protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Relaxing enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Swivelase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Untwisting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">topB_6</name>
        <name evidence="13" type="ORF">ERS852478_03096</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201150.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53132">
        <property type="protein sequence ID" value="CUO53132"/>
        <property type="gene ID" value="ERS852478_03096"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005738">
        <property type="entry name" value="TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PTHR11390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01056">
        <property type="entry name" value="topB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="12">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO53132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="693" mass="76719" checksum="2F80E9E36E8D49F8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FU48</accession>
    <name>A0A174FU48_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_005335912.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPF010000047.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53723">
        <property type="protein sequence ID" value="CUO53723"/>
        <property type="gene ID" value="ERS852478_03117"/>
    </dbReference>
    <dbReference type="GeneID" id="43514867"/>
    <dbReference type="GeneID" id="66495697"/>
    <dbReference type="eggNOG" id="ENOG502ZBQ6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026989">
        <property type="entry name" value="TnpV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14198">
        <property type="entry name" value="TnpV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO53723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="125" mass="14782" checksum="2488660CC7AD6532" modified="2016-09-07" version="1">MSELKPRITENGIDYILVGDYYIPGLKLPEEHRPIGKYGRMHREYLREVHPARLNTLILTGELLTYLADLNEQAQKRLDTIMEQMKATEGVTEELKCTRQMEWVQRCNNIHNRAEEIVLYEMIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FV17</accession>
    <name>A0A174FV17_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO54142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579832.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54142">
        <property type="protein sequence ID" value="CUO54142"/>
        <property type="gene ID" value="ERS852478_03133"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12844">
        <property type="entry name" value="HTH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO54142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="268" mass="31029" checksum="DBF9FE87C05A8442" modified="2016-09-07" version="1">MKGATTIQERLWELRKDKGLNLEELSELTGISKSALGSYEKEDYKEINHGNLITLADFYEVSVDYLLCRTENREQINTPLTGLHLNDEMVALLKSGRINNRLLCELATHKDFIKFLADIEIYVDGIATMQIQNLNALVDTVRHEIIERYRPGEDDPHLKVLQAAHISDDEYFSHMVLDDLNLIIRDIREAHKKDSESAPQTTVADELKENLEAVENFKGSRDEKLVILYCKQLGINYKNLSEEEFRWLIRILKKSKKMGTPISQRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FV46</accession>
    <name>A0A174FV46_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO54172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579830.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPI010000022.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO54172">
        <property type="protein sequence ID" value="CUO54172"/>
        <property type="gene ID" value="ERS852478_03134"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502Z94P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO54172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="216" mass="25264" checksum="8E47F45E80CCE63E" modified="2016-09-07" version="1">MKEKSKSEVSIIGGADGPTSIFIAGRTRKKPLKVRIRNIIYRYRRKIVEKKVVADSHTLDELVQYAMNTYNLIETNSTERKYIEQQKNLKESLILQHKPEVLGEMKDIPKPDVSNEESVREYFCKIKTRSEMIAEMPDNVIPMNFHLYEIRIGDDSLEMEIDYIWNIFGISYSGNKKVMKQFEKISKDLYIYYGVSEDDIKKKTERYLSLVTALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FWY8</accession>
    <name>A0A174FWY8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000026">
        <property type="protein sequence ID" value="CUO53080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201146.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000026.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO53080">
        <property type="protein sequence ID" value="CUO53080"/>
        <property type="gene ID" value="ERS852478_03094"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO53080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="314" mass="36376" checksum="CA2CC3E2937FC7F5" modified="2016-09-07" version="1">MKLQKFENVDVIASLEAIMKQNTAFYQSDFDIDKQLLQKAAVSPVPEDKRLLWFSRPSGTCCFRERDVFLKDTRQHNTWRFYGEQTRDTILAYAVELTGTEQGKIKGNLYELDYLQHFREVIEKAIPADNYTLIYEHGELTKPAGQYFDGNTDPQLGKFIRFEAQPNNPEALKSLLREQQKKRTPHTQGDFQLHIAALHDRRIETEARRIVENVKGLGEPDSPEKTHCAVELSPYFVPLATDKDMERLFSMLPYKNLSFSTLEGRHGIYALIDKSERNKEMKKSRPSVRAQLQTEKSPKVPKKTVKSKNHELEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G4Q3</accession>
    <name>A0A174G4Q3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ilvB_3</name>
        <name evidence="14" type="synonym">ilvB</name>
        <name evidence="13" type="synonym">ilvB_1</name>
        <name evidence="12" type="ORF">ERS852478_03200</name>
        <name evidence="13" type="ORF">ERS852523_01939</name>
        <name evidence="15" type="ORF">GT712_14570</name>
        <name evidence="14" type="ORF">GT728_18245</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 16 17" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">2789STDY5834863</strain>
            <strain evidence="13 17">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="14 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 19">BIOML-A1</strain>
            <strain evidence="15 18">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000018">
        <property type="protein sequence ID" value="CUP53694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000068">
        <property type="protein sequence ID" value="MZL35065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000032">
        <property type="protein sequence ID" value="MZS90260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055151287.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000068.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000004_gene1927"/>
    <dbReference type="EnsemblBacteria" id="CUO56587">
        <property type="protein sequence ID" value="CUO56587"/>
        <property type="gene ID" value="ERS852478_03200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP53694">
        <property type="protein sequence ID" value="CUP53694"/>
        <property type="gene ID" value="ERS852523_01939"/>
    </dbReference>
    <dbReference type="GeneID" id="66493907"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="192"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="382"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO56587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUP53694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MZL35065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZS90260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="563" mass="60984" checksum="E4DBE0D25436B6CF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="8" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G7J4</accession>
    <name>A0A174G7J4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein family UPF0027</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000029">
        <property type="protein sequence ID" value="CUO57981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO57981">
        <property type="protein sequence ID" value="CUO57981"/>
        <property type="gene ID" value="ERS852478_03245"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO57981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="103" mass="11794" checksum="A0D5DA36686CD65E" modified="2016-09-07" version="1">MKCQKVFHTIHNYIDTDEMILRKSTIAAHAGEKVLIPINMRDGSVWRWEKAIQNSSSSQNRISINSSGMSPKSGEIESRLMLRTSAIFLKFPVWESGHSFRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174G9B1</accession>
    <name>A0A174G9B1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Helix-turn-helix domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Predicted transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BWLFYP14_03424</name>
        <name evidence="3" type="ORF">ERS852478_03256</name>
        <name evidence="4" type="ORF">GT712_16805</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
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                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
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        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">Blautia_wexlerae_LFYP_14</strain>
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        <property type="gene ID" value="ERS852478_03256"/>
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                <person name="Venkatesh S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="EMBL" id="VUX62994.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
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            <end position="590"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
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        <name evidence="3" type="ORF">ERS852478_03357</name>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="nucleotide sequence ID" value="NZ_CYZN01000032.1"/>
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        <property type="gene ID" value="ERS852478_03357"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="277"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="302"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO61808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="452" mass="49708" checksum="CD22D5F7F9C367EE" modified="2016-09-07" version="1">MKKLTTGKIWQFAAGQFGWAMLSGIISNWLVYFYQPDKTAISQGQTVFIPQGLVVFGIFTIIGGITAFGRIFDAFTDPMIASLSDRCTSKNGRRIPFLKWASLPLALSTVLVFWSPVNKNSWINGVFLLIMILAYYLSITAYCAPYNALIPELGHTQQERLNISTVISFTFIAGTAVAYLAPTIWGMFIPAFGRVDAIRMTFTLMAAVAFICMLVPVFCIREKDYVDTVPAKESAFGSLAATFKNAEFRKFVASDIFYWIALTMFQTGLPFFVTSLLKLPETMTTLYFVGMTALSLVFYIPVNKLTPKLGKKKMILFAFAVFSFAYFYTGFMGKISFIPASVQGLILTVVAALPMAIFGILPQAVVADISQSDSITSGSNREGMFYAARTFAFKLGQSISMLIFTAVSTIGAAEGTGYRVAAFGAAVFCCIGGIILVFYNEKKINGIINRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GPE2</accession>
    <name>A0A174GPE2_9FIRM</name>
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        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03443</name>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF53098"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="221"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO64444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="564" mass="66113" checksum="E436A518964B5DB8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="6" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
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        <name evidence="1" type="ORF">ERS852478_03375</name>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CUO62335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="64" mass="7612" checksum="FCE7231BEE4D8B62" modified="2016-09-07" version="1">MNFNYCYKITYESGETYDRRRNELSVEISKEDYKKIITGVLQERPIDQIEGISDVIDKMTENVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GUV7</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">ERS852478_03437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000034">
        <property type="protein sequence ID" value="CUO64305.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_020993837.1">
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO64305">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000095431">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO64305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="417" mass="48914" checksum="282A4917EDD80BD6" modified="2016-09-07" version="1">MNILIVGNGFDLAHGLPTKYADFLKFIDFFYKHKAQESSGLELIAGEDINCYKYFTDLFNSKQDSEFDQYLYDQSRKTIHELSDLCKDNAWIKYFSEVYKSREQKGKDGWIDFESEISLIIQTFNSVSRDIQETIQKGGVGTVLSQRQLNVLALFLEKMDSSSGMATHVWKKEEIDFWKQKLLEDLNKLTRALEIYLSDYISNFMLGNGLPDIKNLPYLDKILSFNYTCTYQRIYGEHPFLEFDYVHGKADLRNDIQSTNMVLGIDEYLEGDARDKDLEFIEFKKFFQRIHKETGGLYEGWLEEIQSEKKIYEISAIVKENGIVKKHHRVVKYHKVFIFGHSLDITDKDILRKFILNENVKIIIFYTDKEDYKKKIINLIKIIGQDELVKRTGGKNKTIVFQKINTCTLESDSMREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GXV0</accession>
    <name>A0A174GXV0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AhpC-TSA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BWLFYP14_02349</name>
        <name evidence="2" type="ORF">ERS852478_03479</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000035">
        <property type="protein sequence ID" value="CUO65619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX65979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO65619">
        <property type="protein sequence ID" value="CUO65619"/>
        <property type="gene ID" value="ERS852478_03479"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AhpC-TSA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO65619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="VUX65979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="30" mass="3344" checksum="1537ED4CDBFF8356" modified="2016-09-07" version="1">MLELGIKAPDFELPDQNGEVHKLSDYAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H311</accession>
    <name>A0A174H311_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Excisionase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201461.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69402">
        <property type="protein sequence ID" value="CUO69402"/>
        <property type="gene ID" value="ERS852478_03602"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.50">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tn1545/Tn916_Xis"/>
    </dbReference>
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        <property type="entry name" value="Tn916-Xis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09035">
        <property type="entry name" value="Tn916-Xis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004323">
        <property type="entry name" value="Tn916-Xis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="67" mass="7925" checksum="C69BA5072553F502" modified="2016-09-07" version="1">MSNNDVPIWEKYTLTIEEASKYFRIGENKLRRLSEENPTAGWVILNGNRIQIKRKQFEKIIDSLDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H3P2</accession>
    <name>A0A174H3P2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Resolvase/invertase-type recombinase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69514">
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        <property type="gene ID" value="ERS852478_03607"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
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        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="9"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="132" mass="15124" checksum="4251F562173958FA" modified="2016-09-07" version="1">MAKGQPFEVISDIGSGINYKKKGLQELIRRISQNQVEKVVVLYKDRLLRFGFELIEYIASLYNCEIESIDNTEKSEQQELVEDLVQIITVFSCKLQGKRADKAKKLIRELIQGETDGKSHKSNVDTKQCTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H4Q3</accession>
    <name>A0A174H4Q3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein of uncharacterized function (DUF3847)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008394181.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPG010000073.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70012">
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        <property type="gene ID" value="ERS852478_03622"/>
    </dbReference>
    <dbReference type="GeneID" id="15232334"/>
    <dbReference type="eggNOG" id="ENOG502ZBQ4">
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO70012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="104" mass="12013" checksum="3EF02C8609AD4085" modified="2016-09-07" version="1">MAKSTKSYEERMLEMEKKEQESLEKAKRYAAQKKELLKRKKAEESKKRTHRLCQVGGAVESVLGATIEEEDIPKLIGFLKKQEANGKFFSKAMQKETNTDMEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H524</accession>
    <name>A0A174H524_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
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    <reference evidence="1 2" key="1">
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            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000038">
        <property type="protein sequence ID" value="CUO68436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201443.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000038.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO68436">
        <property type="protein sequence ID" value="CUO68436"/>
        <property type="gene ID" value="ERS852478_03573"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO68436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="128" mass="14633" checksum="D4E110160AE95A9E" modified="2016-09-07" version="1">MTGEKITEQNEDMRVLIIYKGSAEIGKEFQDDYMILELVTDGRPDALASAVINFPLLDGNKSIFIHDLVSYESMEAKESLLEVIEKFARKRGYAAIYINSIRQDRGFLDKEKFMEVSGKTMAKRDVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H6X8</accession>
    <name>A0A174H6X8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_03639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000041">
        <property type="protein sequence ID" value="CUO70614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201475.1">
        <property type="nucleotide sequence ID" value="NZ_JAAIPB010000001.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70614">
        <property type="protein sequence ID" value="CUO70614"/>
        <property type="gene ID" value="ERS852478_03639"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO70614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="175" mass="20334" checksum="00B7124B325D4548" modified="2016-09-07" version="1">MNRELYDEAIRSNILSRKLIEQLMESMNYSNISFINWTVEVLKIIRTRLERGDKITDEVSGITYDIKSFRNFVSTNFSSYITSQVFDAPDKAEKVYFSLEATEDGHAYNMVMANSSKNKTYKWISSLSERFSLVEMIATGIVYLKDNRTDTYQPFISGNGKYCRYDVEKGQIVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H7A5</accession>
    <name>A0A174H7A5_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000039">
        <property type="protein sequence ID" value="CUO69098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201454.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69098">
        <property type="protein sequence ID" value="CUO69098"/>
        <property type="gene ID" value="ERS852478_03590"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="86" mass="9890" checksum="33DA8803C035DECF" modified="2016-09-07" version="1">MELTPTLILNLALLIVPPVALVLVFRQWLARHIRWSVALTALCDVLLFWDELFYYESFGLFAVLILVQLAATGAAAFRFYYKQRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H963</accession>
    <name>A0A174H963_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03610</name>
        <name evidence="3" type="ORF">ERS852523_01451</name>
        <name evidence="4" type="ORF">GT728_07535</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 7">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO69748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000012">
        <property type="protein sequence ID" value="CUP38732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000013">
        <property type="protein sequence ID" value="MZL33057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_015512798.1">
        <property type="nucleotide sequence ID" value="NZ_WWVJ01000013.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO69748">
        <property type="protein sequence ID" value="CUO69748"/>
        <property type="gene ID" value="ERS852478_03610"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP38732">
        <property type="protein sequence ID" value="CUP38732"/>
        <property type="gene ID" value="ERS852523_01451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO69748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP38732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="76" mass="8822" checksum="7B6EC0C19B55D2BF" modified="2016-09-07" version="1">MLRKLNCFLNIVIGSFIGVFIGFGIYKFWHFKTYPNLYAMQSAPWYTELLLDGALVAVLVVVCIILKLIIWRKLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174H9P0</accession>
    <name>A0A174H9P0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted ATP-binding protein involved in virulence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000042">
        <property type="protein sequence ID" value="CUO71652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201489.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000042.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO71652">
        <property type="protein sequence ID" value="CUO71652"/>
        <property type="gene ID" value="ERS852478_03678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="47"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO71652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="425" mass="48819" checksum="94BF61D06B56168F" modified="2016-09-07" version="1">MIIEVRAKNCYAFEDDIIFSMKADMRNKKFGANVHKENNFNVLKTIGIYGPNNAGKTCLIKCIRAIRNVLLNKKNGLMPNIFTDSDVCELGVTFMASGRKFSYDFKYDAEKEEYIYESFSEIFKDQYNNEKEVCWLKKDTVSEIYECIDESVQNMISVVSKNNLLCYVVDTSKFEHINEMKQILVGFAEKIDIINMNNIPMQHTIELMKNKNQLQQKVVEFIKNADLYMDNFEYVDMDKIQLKTGEGDEKPDEKVLDIPENIMDQIRLVSTYKGVHVPSMMFDSTGTKKIAAIASYVIEALEQGRILVVDELDSSIHFKLTRAIVAMFNNELNTSAQMIFTVHDINLMDCKRMFRKEQIWFVHKDEEGVYVYSLADFTAQQGVRDTTDVMEKYRKGALGALPDPELINSLLSIKGDVKGDDADAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HB85</accession>
    <name>A0A174HB85_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase</fullName>
            <ecNumber evidence="2">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aspC</name>
        <name evidence="4" type="ORF">ERS852478_03629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">2789STDY5834863</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CYZN01000040">
        <property type="protein sequence ID" value="CUO70135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_025579287.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000040.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO70135">
        <property type="protein sequence ID" value="CUO70135"/>
        <property type="gene ID" value="ERS852478_03629"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="35"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUO70135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="395" mass="43840" checksum="BCE01FF7D7308782" modified="2016-09-07" version="1">MIAEKMKPYVKNNSAIRMMFEEGNRLRAIYGANKVYDFSLGNPSVPAPECVKEAIIDLVNEVEPTVLHGYMSNAGFEDVRQTIAESLNHRFGTKFAAKNLIMTVGAASGLNVIFKTILNPEEEVIVFAPYFLEYGAYVRNFDGKLVEISPDTTTFQPNLEEFEQKITAKTRAVIVNTPHNPTGVVYSEETIKKLAAILEKKQKEFGSVIYLISDEPYRELAYDGVEVPYLTKYYDNTIVGYSYSKSLSLPGERIGYLVIPDEADGSEELITAAAIANRTIGCVNAPSLMQKVIAKCVDAEVDVAAYDKNRLALYNGLKECGFECIKPQGAFYLFVKSPVADEKAFCEAGKKYNILMVPGSSFACPGYVRLAYCVSYDTIINSLPEFKKLAEEFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HLX3</accession>
    <name>A0A174HLX3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter permease</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="8">FtsX-like permease family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">ERS852478_03800</name>
        <name evidence="9" type="ORF">GT712_00230</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CYZN01000050">
        <property type="protein sequence ID" value="CUO75211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000001">
        <property type="protein sequence ID" value="MZS87557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201532.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000085.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75211">
        <property type="protein sequence ID" value="CUO75211"/>
        <property type="gene ID" value="ERS852478_03800"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="663"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="761"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="287"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO75211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS87557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="797" mass="90679" checksum="9CDD4816F253BEFA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HRG7</accession>
    <name>A0A174HRG7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000053">
        <property type="protein sequence ID" value="CUO75927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201541.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000053.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75927">
        <property type="protein sequence ID" value="CUO75927"/>
        <property type="gene ID" value="ERS852478_03818"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ" evidence="2">
        <location>
            <begin position="47"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO75927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="207" mass="23433" checksum="A38E453E3521751A" modified="2016-09-07" version="1">MLSISDILIRSISGYVFIVPVLLLYFLYLKKSGRKQSFLHITAVFVFCYYLFGILTVAGIGYTSTMSFSPKISLIPFLGMITGPIDTILNLILFVPLGVFLPFLYKRYHHIKTVTLTGFLFSLSVEIVQMFGWGSSDINDLIINTAGACLGYWIYYLLSKALPNNFRKKLQSENVNGTVEVLLFVIYIFMVMVTVQPWVIHDVLNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JCS1</accession>
    <name>A0A174JCS1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 12" type="primary">dxr</name>
        <name evidence="14" type="ORF">BWLFYP14_02382</name>
        <name evidence="11" type="ORF">ERS852478_02062</name>
        <name evidence="12" type="ORF">ERS852523_00026</name>
        <name evidence="13" type="ORF">GT728_13815</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="12 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 15">2789STDY5834863</strain>
            <strain evidence="12 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="13 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 18">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO95005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000035">
        <property type="protein sequence ID" value="MZL34250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX66012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707653.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000073_gene2018"/>
    <dbReference type="EnsemblBacteria" id="CUO17726">
        <property type="protein sequence ID" value="CUO17726"/>
        <property type="gene ID" value="ERS852478_02062"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95005">
        <property type="protein sequence ID" value="CUO95005"/>
        <property type="gene ID" value="ERS852523_00026"/>
    </dbReference>
    <dbReference type="GeneID" id="66493736"/>
    <dbReference type="eggNOG" id="COG0743">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="4"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="143"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="258"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUO17726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CUO95005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZL34250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX66012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="380" mass="42442" checksum="6D2978B3131B6FD0" modified="2016-09-07" version="1">MKKVAVLGSTGSIGTQTLDVVRANDDLEVVGLAAGSNVEMLEKQIREFHPRLVAVWKEEAARDLAVRVQDLDVKIVSQMGGLIELARMEESDILVTAIVGMIGIRPTMEAILAGKDIALANKETLVTAGHLIMPLAKQFGVQILPVDSEHSAIFQALHGEKREQIHKLLITASGGPFRGKKTADLEKVTLEDTLKHPNWVMGQKITVDSATLVNKGLEVMEARWLFDVDLDHIQVVVQPQSIIHSMVEFEDGAVMAQLGTPDMRLPIQYALCYPDRRFLKGDRLDFHMLKQITFEEPDRKTFKGLPMAVEAARAGGSMPTVFNAANELAVRKFLQKKISFLDIYEIIGQSMSRHTAVKDPDLDQILEIEKETYRWIESRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174JDS0</accession>
    <name>A0A174JDS0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aspartate carbamoyltransferase regulatory chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pyrI</name>
        <name evidence="13" type="ORF">BWLFYP14_02398</name>
        <name evidence="9" type="ORF">ERS852478_02046</name>
        <name evidence="10" type="ORF">ERS852523_00043</name>
        <name evidence="12" type="ORF">GT712_14030</name>
        <name evidence="11" type="ORF">GT728_13735</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in allosteric regulation of aspartate carbamoyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PyrI family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000012">
        <property type="protein sequence ID" value="CUO17233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000001">
        <property type="protein sequence ID" value="CUO95335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000035">
        <property type="protein sequence ID" value="MZL34238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000030">
        <property type="protein sequence ID" value="MZS90160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000046">
        <property type="protein sequence ID" value="VUX66027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707627.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000035.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000005_gene2210"/>
    <dbReference type="EnsemblBacteria" id="CUO17233">
        <property type="protein sequence ID" value="CUO17233"/>
        <property type="gene ID" value="ERS852478_02046"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO95335">
        <property type="protein sequence ID" value="CUO95335"/>
        <property type="gene ID" value="ERS852523_00043"/>
    </dbReference>
    <dbReference type="GeneID" id="66492641"/>
    <dbReference type="eggNOG" id="COG1781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009347">
        <property type="term" value="C:aspartate carbamoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020545">
        <property type="entry name" value="Asp_carbamoyltransf_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002801">
        <property type="entry name" value="Asp_carbamoylTrfase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020542">
        <property type="entry name" value="Asp_carbamoyltrfase_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036792">
        <property type="entry name" value="Asp_carbatrfase_reg_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036793">
        <property type="entry name" value="Asp_carbatrfase_reg_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35805">
        <property type="entry name" value="PTHR35805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01948">
        <property type="entry name" value="PyrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02748">
        <property type="entry name" value="PyrI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54893">
        <property type="entry name" value="SSF54893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57825">
        <property type="entry name" value="SSF57825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PyrI" evidence="7">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="PyrI_C" evidence="8">
        <location>
            <begin position="96"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO17233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUO95335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL34238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS90160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX66027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="145" mass="16561" checksum="3487D233E11AF369" modified="2016-09-07" version="1">MLNVGALREGYVLDHIKAGKAMTIYHDLKLDKLDCTVAIIKNARSNKMGKKDIIKVECPVENLDLDILGFIDHNITVNVIKDEKIVAKKELKLPNQVVNVIKCKNPRCITSIEQGLDQIFVLADKEKEVYRCKYCEEKYTGKRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KA90</accession>
    <name>A0A174KA90_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF3784 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Domain of uncharacterized function (DUF3784)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01200</name>
        <name evidence="3" type="ORF">ERS852523_00519</name>
        <name evidence="5" type="ORF">GT712_03760</name>
        <name evidence="4" type="ORF">GT728_00195</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 6 7" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">2789STDY5834863</strain>
            <strain evidence="3 7">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 8 9" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 9">BIOML-A1</strain>
            <strain evidence="5 8">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN83636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP08872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704043.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000001.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2103"/>
    <dbReference type="EnsemblBacteria" id="CUN83636">
        <property type="protein sequence ID" value="CUN83636"/>
        <property type="gene ID" value="ERS852478_01200"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08872">
        <property type="protein sequence ID" value="CUP08872"/>
        <property type="gene ID" value="ERS852523_00519"/>
    </dbReference>
    <dbReference type="GeneID" id="66494035"/>
    <dbReference type="eggNOG" id="ENOG5033ZBJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017259">
        <property type="entry name" value="UCP037672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12650">
        <property type="entry name" value="DUF3784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN83636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP08872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL31652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS88229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="98" mass="10534" checksum="06B58953F0D7B4AC" modified="2016-09-07" version="1">MNFDSLNIILTIAAFIVGIMLLTGHGDIFLKGGNSDISKKLYDEEKMAKASGVALILIGVVSAIDLFTTALAFKIAYIAALLIIIVGLVCYLRLKCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KFM3</accession>
    <name>A0A174KFM3_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">argR</name>
        <name evidence="14" type="ORF">BWLFYP14_03065</name>
        <name evidence="10" type="ORF">ERS852478_01169</name>
        <name evidence="11" type="ORF">ERS852523_00490</name>
        <name evidence="13" type="ORF">GT712_03610</name>
        <name evidence="12" type="ORF">GT728_00345</name>
    </gene>
    <organism evidence="11 16">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="11 15 16" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 15">2789STDY5834863</strain>
            <strain evidence="11 16">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="12 18 19" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 19">BIOML-A1</strain>
            <strain evidence="13 18">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="14 17" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgR family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000006">
        <property type="protein sequence ID" value="CUN82547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000004">
        <property type="protein sequence ID" value="CUP08059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000001">
        <property type="protein sequence ID" value="MZL31682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000005">
        <property type="protein sequence ID" value="MZS88199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000074">
        <property type="protein sequence ID" value="VUX66789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704088.1">
        <property type="nucleotide sequence ID" value="NZ_JADPFJ010000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000006_gene2133"/>
    <dbReference type="EnsemblBacteria" id="CUN82547">
        <property type="protein sequence ID" value="CUN82547"/>
        <property type="gene ID" value="ERS852478_01169"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP08059">
        <property type="protein sequence ID" value="CUP08059"/>
        <property type="gene ID" value="ERS852523_00490"/>
    </dbReference>
    <dbReference type="GeneID" id="66494005"/>
    <dbReference type="eggNOG" id="COG1438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01529">
        <property type="entry name" value="argR_whole"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Arg_repressor" evidence="8">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_repressor_C" evidence="9">
        <location>
            <begin position="79"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUN82547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CUP08059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZL31682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MZS88199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="VUX66789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="152" mass="16520" checksum="A2026A713139E82F" modified="2016-09-07" version="1">MKVARHEKIIELIHQYDIDTQEELASRLNEAGFKVTQATVSRDIRALKLTKVAGKDGKSRYAIINNESGSLGEKYTRVLEDTLLSIDVGQNIIVIKTVSGMAMGVAAALDALKWPEILGCIAGDDTIMCAAKTADMALGAAEKLRSFVRLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KGC6</accession>
    <name>A0A174KGC6_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="5">RF MTase</shortName>
            <ecNumber evidence="5">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">prmC</name>
        <name evidence="8" type="ORF">ERS852478_00766</name>
        <name evidence="9" type="ORF">ERS852523_00576</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
            <strain evidence="9 11">2789STDY5834911</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000004">
        <property type="protein sequence ID" value="CUN67448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000005">
        <property type="protein sequence ID" value="CUP11204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380505.1">
        <property type="nucleotide sequence ID" value="NZ_CZAW01000005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000036_gene2415"/>
    <dbReference type="EnsemblBacteria" id="CUN67448">
        <property type="protein sequence ID" value="CUN67448"/>
        <property type="gene ID" value="ERS852478_00766"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP11204">
        <property type="protein sequence ID" value="CUP11204"/>
        <property type="gene ID" value="ERS852523_00576"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="7">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltranfer_dom" evidence="6">
        <location>
            <begin position="115"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="220"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUN67448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUP11204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <sequence length="321" mass="36343" checksum="DD77B0C264174B82" modified="2016-09-07" version="1">MNGETLTGLLKKGQMILAQAGIKEAGLDAWLLLEYVTGKSRAYYFAYGEESVTESVAERYLELISRRAGHIPLQHLTHQAFFMGHEFYVDKNVLVPRQDTETLVESALECMKAVKNPYILDMCTGSGCILISILKERADAHGTGVDLSDEALKVAVRNARTLEVAEHAEFVQSNLFSEMQNIVYGTEYMKRTAVKDTVKMTECENSNRNYSRAYDMIISNPPYIPTAEIEDLMDEVKLHDPRMALDGMEDGLYFYRAITKQAQDHLVPGGWLLYEIGCSQGEDVSALLRKYKFEDIEIRQDLAGLDRVVLGRKKLQEDKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KV66</accession>
    <name>A0A174KV66_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coenzyme F420-reducing hydrogenase, delta subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Hydrogenase iron-sulfur subunit</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">Methyl-viologen-reducing hydrogenase, delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BWLFYP14_02540</name>
        <name evidence="3" type="ORF">ERS852478_00039</name>
        <name evidence="4" type="ORF">ERS852523_00728</name>
        <name evidence="6" type="ORF">GT712_07710</name>
        <name evidence="5" type="ORF">GT728_12820</name>
    </gene>
    <organism evidence="4 9">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="4 8 9" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">2789STDY5834863</strain>
            <strain evidence="4 9">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="5 11 12" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 12">BIOML-A1</strain>
            <strain evidence="6 11">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="7 10" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000001">
        <property type="protein sequence ID" value="CUN41830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP15892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000031">
        <property type="protein sequence ID" value="MZL34060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000012">
        <property type="protein sequence ID" value="MZS88957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000051">
        <property type="protein sequence ID" value="VUX66168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008703025.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000031.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1403"/>
    <dbReference type="EnsemblBacteria" id="CUN41830">
        <property type="protein sequence ID" value="CUN41830"/>
        <property type="gene ID" value="ERS852478_00039"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP15892">
        <property type="protein sequence ID" value="CUP15892"/>
        <property type="gene ID" value="ERS852523_00728"/>
    </dbReference>
    <dbReference type="GeneID" id="66492893"/>
    <dbReference type="eggNOG" id="COG1908">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003813">
        <property type="entry name" value="MvhD/FlpD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02662">
        <property type="entry name" value="FlpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FlpD" evidence="2">
        <location>
            <begin position="13"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUN41830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CUP15892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZL34060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MZS88957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="VUX66168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="147" mass="16623" checksum="47D2D07A15B4535C" modified="2016-09-07" version="1">MSIETNEEFRPKIVAFCCNWCSYAGADLAGSSRLSYPADVKIIRVPCSCRVNPMFILRAFEKGADGVIMCGCHPGDCHYSTGNYYARRRMTLLFSMLDYIGVENGRTRVEWVSAAEGVKFSQTMNEFVEKIHSLGKNVRLEDLRCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174KY92</accession>
    <name>A0A174KY92_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein ZapA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">zapA</name>
        <name evidence="6" type="ORF">BWLFYP14_00980</name>
        <name evidence="2" type="ORF">ERS852478_01498</name>
        <name evidence="3" type="ORF">ERS852523_00781</name>
        <name evidence="5" type="ORF">GT712_13060</name>
        <name evidence="4" type="ORF">GT728_10995</name>
    </gene>
    <organism evidence="3 8">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 7 8" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 7">2789STDY5834863</strain>
            <strain evidence="3 8">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 10 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 11">BIOML-A1</strain>
            <strain evidence="5 10">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP17254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000024">
        <property type="protein sequence ID" value="MZL33710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000026">
        <property type="protein sequence ID" value="MZS89975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704329.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1353"/>
    <dbReference type="EnsemblBacteria" id="CUN96153">
        <property type="protein sequence ID" value="CUN96153"/>
        <property type="gene ID" value="ERS852478_01498"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17254">
        <property type="protein sequence ID" value="CUP17254"/>
        <property type="gene ID" value="ERS852523_00781"/>
    </dbReference>
    <dbReference type="GeneID" id="66492604"/>
    <dbReference type="eggNOG" id="COG3027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007838">
        <property type="entry name" value="Cell_div_ZapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036192">
        <property type="entry name" value="Cell_div_ZapA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05164">
        <property type="entry name" value="ZapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102829">
        <property type="entry name" value="SSF102829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN96153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP17254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZL33710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MZS89975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="VUX63494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="135" mass="15713" checksum="52A0A7A203273990" modified="2016-09-07" version="1">MAVKNTAKVIIGGKIITLGGYESEEYFQKVASYINKKMDELSAMPGYSRQPMETKHTLISLNITDDYFKAKKQAEVFEQDLQQKDQEMYDLKHELISLRMQIEEAQKHEQEALEQKSLLEGKNKELEKQIDELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174L5D0</accession>
    <name>A0A174L5D0_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ion-translocating oxidoreductase complex subunit A</fullName>
            <ecNumber evidence="8">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rnf electron transport complex subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">rnfA</name>
        <name evidence="11" type="synonym">rsxA</name>
        <name evidence="13" type="ORF">BWLFYP14_00984</name>
        <name evidence="9" type="ORF">ERS852478_01494</name>
        <name evidence="10" type="ORF">ERS852523_00785</name>
        <name evidence="12" type="ORF">GT712_13080</name>
        <name evidence="11" type="ORF">GT728_10975</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN96000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000006">
        <property type="protein sequence ID" value="CUP17358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000024">
        <property type="protein sequence ID" value="MZL33706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000026">
        <property type="protein sequence ID" value="MZS89979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000027">
        <property type="protein sequence ID" value="VUX63498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008704334.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000024.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000002_gene1349"/>
    <dbReference type="EnsemblBacteria" id="CUN96000">
        <property type="protein sequence ID" value="CUN96000"/>
        <property type="gene ID" value="ERS852478_01494"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP17358">
        <property type="protein sequence ID" value="CUP17358"/>
        <property type="gene ID" value="ERS852523_00785"/>
    </dbReference>
    <dbReference type="GeneID" id="66492608"/>
    <dbReference type="eggNOG" id="COG4657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00459">
        <property type="entry name" value="RsxA_RnfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011293">
        <property type="entry name" value="Ion_transpt_RnfA/RsxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01943">
        <property type="entry name" value="rnfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUN96000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP17358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL33706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS89979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX63498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="191" mass="20367" checksum="945B825B20A35907" modified="2016-09-07" version="1">MKELLIILVSSAIVNNVVLSQFLGLCPFLGVSKSVETAAGMGGAIIFVITLSSFVTGIIYNAILVPTNLTYLQTIVFILLIAALVQFVEMFLKKTMPSLYQALGVYLPLITTNCAVLGVALTNVQKEYNVLQGTVNGFATAVGFTISIVLMAGIREKIAYNDIPKSFQGFPTVLLTAGLMAIAFFGFSGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174MC48</accession>
    <name>A0A174MC48_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="11">RNAP subunit alpha</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">rpoA</name>
        <name evidence="17" type="ORF">BWLFYP14_00282</name>
        <name evidence="13" type="ORF">ERS852478_01684</name>
        <name evidence="14" type="ORF">ERS852523_01268</name>
        <name evidence="16" type="ORF">GT712_08850</name>
        <name evidence="15" type="ORF">GT728_04830</name>
    </gene>
    <organism evidence="14 19">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="14 18 19" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 18">2789STDY5834863</strain>
            <strain evidence="14 19">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="15 21 22" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 22">BIOML-A1</strain>
            <strain evidence="16 21">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="17 20" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="CYZN01000009">
        <property type="protein sequence ID" value="CUO03552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000010">
        <property type="protein sequence ID" value="CUP32846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000008">
        <property type="protein sequence ID" value="MZL32544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000015">
        <property type="protein sequence ID" value="MZS89175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000084">
        <property type="protein sequence ID" value="VUX67441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008707285.1">
        <property type="nucleotide sequence ID" value="NZ_JADPFJ010000008.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000046_gene2956"/>
    <dbReference type="EnsemblBacteria" id="CUO03552">
        <property type="protein sequence ID" value="CUO03552"/>
        <property type="gene ID" value="ERS852478_01684"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP32846">
        <property type="protein sequence ID" value="CUP32846"/>
        <property type="gene ID" value="ERS852523_01268"/>
    </dbReference>
    <dbReference type="GeneID" id="66496148"/>
    <dbReference type="eggNOG" id="COG0202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RPOLD" evidence="12">
        <location>
            <begin position="20"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="11">
        <location>
            <begin position="249"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CUO03552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CUP32846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MZL32544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MZS89175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="VUX67441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="319" mass="35206" checksum="8C61A0188B25BB36" modified="2016-09-07" version="1">MFDFNKPKIEITELSEDKKFGRFVVEPLERGYGTTLGNSLRRIMLSSLPGAAVSQVKIDGVLHEFSSIPGVKEDVSDIIMNLKSLAIKNHSTDNEPKTAYIECEGKGVVTAADIQADQDIEIMNPDQVIATLNGGKDCRLAMELTITKGRGYISADKGKSDDMPIGVLAVDAIYTPVDRVNMTVENTRVGQVTDYDKLTLDVYTNGTLDPDEAVSLAAKVLSEHLSLFIDLSENAKTAEVMIEKEDNEKEKVLEMSIDELELSVRSYNCLKRAGINTVEELCNKTSDDMMKVRNLGRKSLEEVLAKLKELGLQLQPAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174NZ16</accession>
    <name>A0A174NZ16_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">srrA_4</name>
        <name evidence="13" type="synonym">srrA_2</name>
        <name evidence="9" type="synonym">srrA_3</name>
        <name evidence="13" type="ORF">BWLFYP14_02233</name>
        <name evidence="9" type="ORF">ERS852478_03211</name>
        <name evidence="10" type="ORF">ERS852523_01950</name>
        <name evidence="12" type="ORF">GT712_18180</name>
        <name evidence="11" type="ORF">GT728_20380</name>
    </gene>
    <organism evidence="10 15">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="10 14 15" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">2789STDY5834863</strain>
            <strain evidence="10 15">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="11 17 18" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 18">BIOML-A1</strain>
            <strain evidence="12 17">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="13 16" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000028">
        <property type="protein sequence ID" value="CUO56912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000018">
        <property type="protein sequence ID" value="CUP54004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000101">
        <property type="protein sequence ID" value="MZL35459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000057">
        <property type="protein sequence ID" value="MZS90920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000039">
        <property type="protein sequence ID" value="VUX65867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_020993968.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000101.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000004_gene1939"/>
    <dbReference type="EnsemblBacteria" id="CUO56912">
        <property type="protein sequence ID" value="CUO56912"/>
        <property type="gene ID" value="ERS852478_03211"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP54004">
        <property type="protein sequence ID" value="CUP54004"/>
        <property type="gene ID" value="ERS852523_01950"/>
    </dbReference>
    <dbReference type="GeneID" id="66493896"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="8">
        <location>
            <begin position="128"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="6">
        <location>
            <begin position="128"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CUO56912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CUP54004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MZL35459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MZS90920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="VUX65867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="226" mass="25927" checksum="9536C108BD73523B" modified="2016-09-07" version="1">MDTLKILVVDDESRMRKLVKDFLTKKNFQVLEAGNGEEAMDIFYEEKDIALIILDVMMPKMDGWEVCREIRKNSKVPIIMLTARSDERDELLGFDLGVDEYISKPFSPKILVARVEAILRRTGQNNPEDVISAGGIVIDKAAHLATVDGKPMELSFKEFELLTYFLENQGIALSREKILNSVWNYDYFGDARTIDTHVKKLRSKMGDKGEYIKTVWGMGYKFEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174Q3H0</accession>
    <name>A0A174Q3H0_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BWLFYP14_01484</name>
        <name evidence="2" type="ORF">ERS852478_02231</name>
        <name evidence="3" type="ORF">ERS852523_02424</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">2789STDY5834863</strain>
            <strain evidence="3 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="4 7" key="2">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000014">
        <property type="protein sequence ID" value="CUO24142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000025">
        <property type="protein sequence ID" value="CUP67803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000035">
        <property type="protein sequence ID" value="VUX64631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022380872.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000039.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000042_gene3025"/>
    <dbReference type="EnsemblBacteria" id="CUO24142">
        <property type="protein sequence ID" value="CUO24142"/>
        <property type="gene ID" value="ERS852478_02231"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP67803">
        <property type="protein sequence ID" value="CUP67803"/>
        <property type="gene ID" value="ERS852523_02424"/>
    </dbReference>
    <dbReference type="GeneID" id="66493788"/>
    <dbReference type="eggNOG" id="ENOG5033B4Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO24142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUP67803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="VUX64631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <sequence length="50" mass="5313" checksum="D4C50EA742E57E9B" modified="2016-09-07" version="1">MNEKIYKTMSSTGACSLTVGIIVLATGIVTGIMMIVNGARLLKKKSEILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174QXF7</accession>
    <name>A0A174QXF7_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">33 kDa chaperonin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 33 homolog</fullName>
            <shortName evidence="6">HSP33</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">hslO</name>
        <name evidence="10" type="ORF">BWLFYP14_02050</name>
        <name evidence="7" type="ORF">ERS852478_00436</name>
        <name evidence="8" type="ORF">ERS852523_02737</name>
        <name evidence="9" type="ORF">GT712_06515</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 11">2789STDY5834863</strain>
            <strain evidence="8 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="9 14" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HSP33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN54481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000031">
        <property type="protein sequence ID" value="CUP76621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000009">
        <property type="protein sequence ID" value="MZS88732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000037">
        <property type="protein sequence ID" value="VUX65459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706643.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000020.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000051_gene795"/>
    <dbReference type="EnsemblBacteria" id="CUN54481">
        <property type="protein sequence ID" value="CUN54481"/>
        <property type="gene ID" value="ERS852478_00436"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUP76621">
        <property type="protein sequence ID" value="CUP76621"/>
        <property type="gene ID" value="ERS852523_02737"/>
    </dbReference>
    <dbReference type="GeneID" id="66496067"/>
    <dbReference type="eggNOG" id="COG1281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00498">
        <property type="entry name" value="Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00117">
        <property type="entry name" value="HslO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000397">
        <property type="entry name" value="Heat_shock_Hsp33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016154">
        <property type="entry name" value="Heat_shock_Hsp33_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016153">
        <property type="entry name" value="Heat_shock_Hsp33_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30111">
        <property type="entry name" value="PTHR30111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01430">
        <property type="entry name" value="HSP33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005261">
        <property type="entry name" value="Heat_shock_Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118352">
        <property type="entry name" value="SSF118352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64397">
        <property type="entry name" value="SSF64397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="2 6" id="KW-0862">Zinc</keyword>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="237"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUN54481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUP76621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS88732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX65459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="292" mass="31896" checksum="90595AAE1AC88AD0" modified="2016-09-07" version="1">MNDYIIRAIAANDQIRAFAAVTTETVETARQDHNTSPVATAALGRLLTAGAMMGTMMKGDKDILTLQIKAGGPLEGITVTADSKGRVKGYVGNPDVCIPANSKGKLDVAGAVGVGFMNVIKDMGLKEPYVGQVALQTSEIAEDLTYYFATSEQVPSAVGLGVLMNKDNTVRQAGGFIVQLMPFAEESTIAKLEENVQKITSVTNLLEEGHTPESLLEKVLEGFDMEINEKVPTEFYCNCSRERVEKALISIGRKELNEMIQEGKSIEMNCHFCNKNYEFTVEELKEILRKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174SVK1</accession>
    <name>A0A174SVK1_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF2284 domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Predicted metal-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">ERS852478_01786</name>
        <name evidence="2" type="ORF">ERS852523_03629</name>
        <name evidence="4" type="ORF">GT712_11990</name>
        <name evidence="3" type="ORF">GT728_05640</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
            <strain evidence="2 6">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="3 7 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 8">BIOML-A1</strain>
            <strain evidence="4 7">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO07528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000057">
        <property type="protein sequence ID" value="CUQ01632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000009">
        <property type="protein sequence ID" value="MZL32701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000023">
        <property type="protein sequence ID" value="MZS89773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381148.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000009.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000014_gene1249"/>
    <dbReference type="EnsemblBacteria" id="CUO07528">
        <property type="protein sequence ID" value="CUO07528"/>
        <property type="gene ID" value="ERS852478_01786"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ01632">
        <property type="protein sequence ID" value="CUQ01632"/>
        <property type="gene ID" value="ERS852523_03629"/>
    </dbReference>
    <dbReference type="GeneID" id="66493416"/>
    <dbReference type="eggNOG" id="COG5423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019271">
        <property type="entry name" value="DUF2284_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10050">
        <property type="entry name" value="DUF2284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUO07528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUQ01632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS89773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="178" mass="20322" checksum="1C04AAAAEFFE7B97" modified="2016-09-07" version="1">MDIKKIEQMGMEQGFSHVVLLDCDTIELKPEVRQMCAADTCHKYDKCWSCPPGCGSLEECEAKVRQYKYGIIVQTVGELEDVFDGEGMMETEARHKEYFVEFEKKLREIYPDMLAIGAGCCTKCKVCTYPDAPCRFPKQAFSSMEAYGMLVTQVCQANELQYYYGDCTIAYTSCYLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173XMM3</accession>
    <name>A0A173XMM3_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromosome condensation protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">Surfactin synthase subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">srfAA_1</name>
        <name evidence="2" type="ORF">ERS852478_00355</name>
        <name evidence="3" type="ORF">GT728_06545</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">BIOML-A1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000002">
        <property type="protein sequence ID" value="CUN52097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000011">
        <property type="protein sequence ID" value="MZL32869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008706732.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000011.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN52097">
        <property type="protein sequence ID" value="CUN52097"/>
        <property type="gene ID" value="ERS852478_00355"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="3"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN52097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MZL32869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="462" mass="53417" checksum="C45A7B6DA2AD661F" modified="2016-09-07" version="1">MTNYYPLTAAQKMHHNWIMDYGTQQVSGVSVVASVQAELDFGLLKKCIQMETERSGCTRIRFTKPDKDGNVQQYLVKQDPRDIGFKDLSGMGSLAKADELMQQWAYETFDGDDIPMCEFTMLKLPEGYNGFFVHMDHRLIDSCGLVVMIGDLFQLYTYYKYGTAYPQELADFETVLKKDLAKAGNEKRFAKDKKFWDDQLDALGEPLYSDIQGPSVLEEARKRHGNPKLRSSDIEMKDLFVAVKDYYLEPGPTKNLIDFCMNHQLSMTNLLLLGIRTYLSKVNNGQEDITIQNFISRRSTHDEWTSGGSRTIMFPCRTVIAPETDFLSAAYEIQNMQNRIYMHSNYDPAFIMDEMRKRYNTPEHTGYESCYLTYQPMTVKVENEMLGTIRQHAKWFANGAATKKMYLTVSHTEDGGMNFSYHYQTAHLEEHDMELLYYYMMRILFKGIAEPDMSIGEIMELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>A0A173Y9G2</accession>
    <name>A0A173Y9G2_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">yycF_2</name>
        <name evidence="13" type="synonym">yycF_4</name>
        <name evidence="13" type="ORF">BWLFYP14_03285</name>
        <name evidence="11" type="ORF">ERS852478_00571</name>
        <name evidence="12" type="ORF">GT712_13245</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 14">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="12 16" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
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            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 16">BIOML-A12</strain>
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    <reference evidence="13 15" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
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    <dbReference type="EnsemblBacteria" id="CUN59625">
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        <property type="gene ID" value="ERS852478_00571"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="230" mass="26541" checksum="7A343CC7AE204282" modified="2016-09-07" version="1">MSRKVLVVDDEKLIVKGIRFSLEQDGMEVDCAYDGEEAVEKAKDKKYDIILLDLMLPKMDGLEVCQQIREFSNVPIVMLTAKGEDMDKILGLEYGADDYITKPFNILEVKARIKAIMRRAGSDHEEKEKAKSIQVGDLRMDCEGRRVFIAGKEINLTAKEFDVLELLVFNPNKVYSRENLLNIVWGYEYPGDVRTVDVHIRRLREKIETNPSEPKYVHTKWGVGYYFQAQ</sequence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">2789STDY5834863</strain>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="124" mass="14647" checksum="412A10CE3C8516FF" modified="2016-09-07" version="1">MKIRMDFVTNSSSSSFILARNERLNEKQKDKIIEYVEKTFLGKRILTPESTEEEIQKILDENVFGEEERDAVRKALHDGKMIYSDCVCFEDCLYNYESVYEDIWEIMQENSDGDFEEIDGDLSY</sequence>
</entry>
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    <accession>A0A174A0K4</accession>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 5">2789STDY5834863</strain>
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    <reference evidence="3 8" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
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                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
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                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
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                <person name="Livny J."/>
                <person name="Vlamakis H."/>
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                <person name="Deik A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">Blautia_wexlerae_LFYP_14</strain>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
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    </evidence>
    <sequence length="75" mass="8565" checksum="93BFB40203F4C67E" modified="2016-09-07" version="1">MTCFYCKGNIESSTTTYMTDYQGCYIIIKNVPCEKCSQCGEEYLNGETLERIEEIIQKVKGMLTEIAVVDYKQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="10" xmlns="http://uniprot.org/uniprot">
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN94904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200106.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN94904">
        <property type="protein sequence ID" value="CUN94904"/>
        <property type="gene ID" value="ERS852478_01463"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CUN94904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="240" mass="27175" checksum="89A716A2F6FA1C3D" modified="2016-09-07" version="1">MIKQEVIFNVKNLKISKTENIFATEGIKNVFTAVFQFHSTDWDGLAKTAVFENAEGTKEPKLLEEDRCDIPDSFFKTSGVCYVSVMAGNFMVTNKVAIIVVNAGYTSGDTVAEAKNYFEQILRYFDATNMNVQKYGKLAERFAVGLAEDPESLMDNAKYYAHQAEQAVMGIPGQVEDAKNDIDAYVKEKEADLKGEDGNVCFVEFRIEPPCLYMRNNPDETDIEFRLNGSKLEYKWRERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174B2P8</accession>
    <name>A0A174B2P8_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN95162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200113.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000008.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN95162">
        <property type="protein sequence ID" value="CUN95162"/>
        <property type="gene ID" value="ERS852478_01471"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN95162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="104" mass="11367" checksum="4295EC7C432245E8" modified="2016-09-07" version="1">MTLECFLLLLMIVSILTGLFTEGIKKLLEESKKTYKANFLAGGVAVVLSVLVGSGYIILMDAQINSKMAVYLIALILLSWLSAMVGYDKVIQSLGQIKLPNKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BFF4</accession>
    <name>A0A174BFF4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type transport system involved in multi-copper enzyme maturation, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_01560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000008">
        <property type="protein sequence ID" value="CUN98358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004611593.1">
        <property type="nucleotide sequence ID" value="NZ_JABMHZ010000097.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUN98358">
        <property type="protein sequence ID" value="CUN98358"/>
        <property type="gene ID" value="ERS852478_01560"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUN98358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="273" mass="31348" checksum="E65AA98F8565A140" modified="2016-09-07" version="1">MFNQIRAEFYKLFHTKALYLTFALILAVFGIFSIGGQQQFVASSSSLDETWKIGETVGFLARAYSDTAHPLIEEIIRTATSYTVFFWLIVLIFSVIFFSREYTDSTIKIAIASGQSRIKFFVAKYIVISITSIFLYFSFIMIAFIIECAKFNIPIQLFPMLKIAGLNCMIMGAFIGITLMLCVIFKHTAIVVGAMSLFTFSGPLIYMMTWDNMSTQSWRVLTYLKINPMYYWMNTCSYNMINNLEINILIYFVGTVIITFLVSALILRKQEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174BZ04</accession>
    <name>A0A174BZ04_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein of uncharacterized function (DUF3706)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_01732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000010">
        <property type="protein sequence ID" value="CUO05857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055200195.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000010.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO05857">
        <property type="protein sequence ID" value="CUO05857"/>
        <property type="gene ID" value="ERS852478_01732"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041688">
        <property type="entry name" value="PRTase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022537">
        <property type="entry name" value="TRSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011214">
        <property type="entry name" value="UCP020967"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15609">
        <property type="entry name" value="PRTase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12500">
        <property type="entry name" value="TRSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020967">
        <property type="entry name" value="UCP020967"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRTase_2" evidence="2">
        <location>
            <begin position="8"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="TRSP" evidence="1">
        <location>
            <begin position="240"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO05857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="368" mass="42386" checksum="B0232E0A0853DCDF" modified="2016-09-07" version="1">MEYTEKDLVKIAKRENNTKRNYLVVDPLQGKHIPVVPSKALDLFAALADTFREKYKDEKLLLVGFAETATAIGAQAAITVGADYIQTTREVIPGVNYLFFSEEHSHATEQKLVKDDIDRAVAETDRIIFIEDEVTTGKTIRNIISILDREYDGKFKYSVASLLNGMSEENLERYKRQGISLYYLVKTDHSTYGDRAETFKGDGFYYKCPDKAAEYTTIYVKNRMDARRLIDSGKYEEACENLWREIREKTGNMADNISGKRILVIGTEEFMFPALYIGRKMEKEGAEVRCHSTTRSPIAVSLEKEYPLHSRYELKSLYDPDRRTFIYDIGKYDKVLIVTDSPEIKESQETLINAVRMQNKDITVVRWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174CEN7</accession>
    <name>A0A174CEN7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CDP-glycerol:poly(Glycerophosphate) glycerophosphotransferase</fullName>
            <ecNumber evidence="8">2.7.8.12</ecNumber>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tagF_1</name>
        <name evidence="8" type="ORF">ERS852478_01909</name>
        <name evidence="9" type="ORF">GT712_17500</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">BIOML-A12</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-glycerol glycerophosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.12" evidence="8"/>
    <dbReference type="EMBL" id="CYZN01000011">
        <property type="protein sequence ID" value="CUO12061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000051">
        <property type="protein sequence ID" value="MZS90803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055053628.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000056.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO12061">
        <property type="protein sequence ID" value="CUO12061"/>
        <property type="gene ID" value="ERS852478_01909"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019350">
        <property type="term" value="P:teichoic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043149">
        <property type="entry name" value="TagF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0777">Teichoic acid biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="7">
        <location>
            <begin position="14"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="6">
        <location>
            <begin position="216"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO12061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS90803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="962" mass="113134" checksum="48FDBAAA58DD8D44" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174EJA9</accession>
    <name>A0A174EJA9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glyoxal reductase</fullName>
            <ecNumber evidence="5">1.1.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yvgN</name>
        <name evidence="5" type="ORF">ERS852478_02589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CYZN01000017">
        <property type="protein sequence ID" value="CUO36325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO36325">
        <property type="protein sequence ID" value="CUO36325"/>
        <property type="gene ID" value="ERS852478_02589"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="PTHR43827"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="4">
        <location>
            <begin position="22"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CUO36325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="275" mass="30888" checksum="7EC91E2B962D9052" modified="2016-09-07" version="1">MDNTVFLNTNREMPLLGLGVYKATGENEAENAIISAVESGYRLIDTASVYKNEENVGRGIASCGIPRNELFITTKVWNTAQRLGDIQGAFERSLDRLKLDYVDLYLIHWPVPGCYLSTWKVLEEIQKSGRALSIGVSNFEIRHLEELEANSGIIPAVNQIECHPLCYPKELIDYCQDKGIQVQAYAPLARGAYLDNDVMCVLGTKYAHTPAQIGLRWATQKGISVIPKSVHPDRIRSNGNIFDFTIEQEDMDLIDTLNENFHSSHVPEDLRDIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174F4H7</accession>
    <name>A0A174F4H7_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="8">4Fe-4S dicluster domain-containing protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Electron transport complex protein RnfB</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Ferredoxin II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BWLFYP14_03369</name>
        <name evidence="6" type="ORF">ERS852478_02818</name>
        <name evidence="7" type="ORF">ERS852523_03644</name>
        <name evidence="9" type="ORF">GT712_17400</name>
        <name evidence="8" type="ORF">GT728_08550</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="6 11 12" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 11">2789STDY5834863</strain>
            <strain evidence="7 12">2789STDY5834911</strain>
        </source>
    </reference>
    <reference evidence="8 14 15" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 15">BIOML-A1</strain>
            <strain evidence="9 14">BIOML-A12</strain>
        </source>
    </reference>
    <reference evidence="10 13" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CYZN01000020">
        <property type="protein sequence ID" value="CUO43828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CZAW01000058">
        <property type="protein sequence ID" value="CUQ02067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000016">
        <property type="protein sequence ID" value="MZL33244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000050">
        <property type="protein sequence ID" value="MZS90783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000077">
        <property type="protein sequence ID" value="VUX67092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_008705189.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000016.1"/>
    </dbReference>
    <dbReference type="STRING" id="1121115.AXVN01000104_gene848"/>
    <dbReference type="EnsemblBacteria" id="CUO43828">
        <property type="protein sequence ID" value="CUO43828"/>
        <property type="gene ID" value="ERS852478_02818"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUQ02067">
        <property type="protein sequence ID" value="CUQ02067"/>
        <property type="gene ID" value="ERS852523_03644"/>
    </dbReference>
    <dbReference type="GeneID" id="66494709"/>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095712">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CUO43828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CUQ02067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MZL33244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZS90783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX67092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000095712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="104" mass="11554" checksum="10D96B6A9FB93C8C" modified="2016-09-07" version="1">MSIRIQKSKCAGCGRCIEACPGNLIKKDKENKAFIRQVRDCWGCTSCIKECRHDAIRFFLGADVGGRGASMVVSEKPDISTWTVEKPDGTKITIQVNKKDANKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174FG49</accession>
    <name>A0A174FG49_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_02985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000023">
        <property type="protein sequence ID" value="CUO49194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_055201060.1">
        <property type="nucleotide sequence ID" value="NZ_CYZN01000023.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO49194">
        <property type="protein sequence ID" value="CUO49194"/>
        <property type="gene ID" value="ERS852478_02985"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12641">
        <property type="entry name" value="Flavodoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO49194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="171" mass="19433" checksum="25DE733B0FAA638D" modified="2016-09-07" version="1">MGIQRYSIIYSSKTGNTKKLAEKIREVLPEENCDYFGTEGAKALSSDILYIGFWTDIGNADPVTLELLKSLKNKKIFLFGTAGFGGSEAYFQQVLGKVKESVDESNTVMGEFMCQGKMPQSVRDRYVKMKEKPDHAPNLDELIQNFDRALSHPDNEDLDRLEEVIRRDLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174GHK1</accession>
    <name>A0A174GHK1_9FIRM</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stage 0 sporulation protein A homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lytR_3</name>
        <name evidence="10" type="synonym">ypdB_2</name>
        <name evidence="10" type="ORF">BWLFYP14_00763</name>
        <name evidence="8" type="ORF">ERS852478_03302</name>
        <name evidence="9" type="ORF">GT728_14700</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="8 11" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 11">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="9 13" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 13">BIOML-A1</strain>
        </source>
    </reference>
    <reference evidence="10 12" key="3">
        <citation type="submission" date="2019-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Chang H.-W."/>
                <person name="Raman A."/>
                <person name="Venkatesh S."/>
                <person name="Gehrig J."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Blautia_wexlerae_LFYP_14</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.</text>
    </comment>
    <dbReference type="EMBL" id="CYZN01000031">
        <property type="protein sequence ID" value="CUO59955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVQ01000039">
        <property type="protein sequence ID" value="MZL34413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CABHOF010000019">
        <property type="protein sequence ID" value="VUX63020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381201.1">
        <property type="nucleotide sequence ID" value="NZ_WWVQ01000039.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO59955">
        <property type="protein sequence ID" value="CUO59955"/>
        <property type="gene ID" value="ERS852478_03302"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000366766">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477285">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="7">
        <location>
            <begin position="129"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CUO59955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MZL34413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="VUX63020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000366766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000477285"/>
        </source>
    </evidence>
    <sequence length="235" mass="27638" checksum="D2A4E7BB9D6CBC7C" modified="2016-09-07" version="1">MRILICDDDTLIIEQLKKYIESYFESNHLKCPELVSFTSGEALLTDKGEKDIVFLDIEMPGMNGIYVGNELKKANRNVIVFVVTSYSEYLDEAMRFHVFRYLSKPLDKQRFFRNLKDALAYYNSITLKIPVETKQAVYSFPASQIIAIEAQGRKVIVHTARQDFDSIHNMNYWLEKLPQNSFFQTHRSFIVNFEHIVDFDHSTVHLSNPQITAYLTRRKYSSFRNAYLLYLESMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HKC4</accession>
    <name>A0A174HKC4_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA gyrase inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">ERS852478_03755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">2789STDY5834863</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000047">
        <property type="protein sequence ID" value="CUO73896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO73896">
        <property type="protein sequence ID" value="CUO73896"/>
        <property type="gene ID" value="ERS852478_03755"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CUO73896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <sequence length="70" mass="8337" checksum="B1E1D44761F23059" modified="2016-09-07" version="1">MSIEEISLGVGYENQSYFFRQFKKRYGMILRRYRIEKGQKVCKLLKNSERVGMLFTLQGKRINVKVNDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A174HNL9</accession>
    <name>A0A174HNL9_9FIRM</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">ERS852478_03795</name>
        <name evidence="4" type="ORF">GT712_14655</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Blautia wexlerae</name>
        <dbReference type="NCBI Taxonomy" id="418240"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Firmicutes</taxon>
            <taxon>Clostridia</taxon>
            <taxon>Eubacteriales</taxon>
            <taxon>Lachnospiraceae</taxon>
            <taxon>Blautia</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2015-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="Pathogen Informatics"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">2789STDY5834863</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Nat. Med." volume="25" first="1442" last="1452">
            <title>A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.</title>
            <authorList>
                <person name="Poyet M."/>
                <person name="Groussin M."/>
                <person name="Gibbons S.M."/>
                <person name="Avila-Pacheco J."/>
                <person name="Jiang X."/>
                <person name="Kearney S.M."/>
                <person name="Perrotta A.R."/>
                <person name="Berdy B."/>
                <person name="Zhao S."/>
                <person name="Lieberman T.D."/>
                <person name="Swanson P.K."/>
                <person name="Smith M."/>
                <person name="Roesemann S."/>
                <person name="Alexander J.E."/>
                <person name="Rich S.A."/>
                <person name="Livny J."/>
                <person name="Vlamakis H."/>
                <person name="Clish C."/>
                <person name="Bullock K."/>
                <person name="Deik A."/>
                <person name="Scott J."/>
                <person name="Pierce K.A."/>
                <person name="Xavier R.J."/>
                <person name="Alm E.J."/>
            </authorList>
            <dbReference type="PubMed" id="31477907"/>
            <dbReference type="DOI" id=".1038/s41591-019-0559-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">BIOML-A12</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CYZN01000050">
        <property type="protein sequence ID" value="CUO75106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="WWVF01000033">
        <property type="protein sequence ID" value="MZS90277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_022381292.1">
        <property type="nucleotide sequence ID" value="NZ_WWVH01000034.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="CUO75106">
        <property type="protein sequence ID" value="CUO75106"/>
        <property type="gene ID" value="ERS852478_03795"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000095431">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000477156">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Mrr_cat" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CUO75106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MZS90277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000095431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000477156"/>
        </source>
    </evidence>
    <sequence length="222" mass="25014" checksum="3DD05C40605840D2" modified="2016-09-07" version="1">MDGYEFEYQCAKILKRKHFSKIKVTQSSGDQGIDIIAFKHRKKYGIQCKYYTHPVGNKAVQEAYAGANFYDCDKAVVMTNITFTKSATQLAQKLDVELWPNCPVTPFYSLPFKIMSSLNAVLFLYAVLAFLSLKPEFDFIHLPFVPDTLTLIIILTASISGIFGWSFFLCNLIAAGTYLYLAFHTLILPTYAETGSCTNIHLLSLIPAGVYLLHAGWIKIRK</sequence>
</entry>
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</uniprot>